CHRNG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mammalian muscle-type acetylcholine receptor is a transmembrane pentameric glycoprotein with two alpha subunits, one beta, one delta, and one epsilon (in adult skeletal muscle) or gamma (in fetal and denervated muscle) subunit. This gene, which encodes the gamma subunit, is expressed prior to the thirty-third week of gestation in humans. The gamma subunit of the acetylcholine receptor plays a role in neuromuscular organogenesis and ligand binding and disruption of gamma subunit expression prevents the correct localization of the receptor in cell membranes. Mutations in this gene cause Escobar syndrome and a lethal form of multiple pterygium syndrome. Muscle-type acetylcholine receptor is the major antigen in the autoimmune disease myasthenia gravis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1musculoskeletal movement (GO:0050881)9.60309443
2multicellular organismal movement (GO:0050879)9.60309443
3myotube cell development (GO:0014904)9.25845046
4myoblast fusion (GO:0007520)9.17319048
5muscle cell fate commitment (GO:0042693)8.69639624
6syncytium formation by plasma membrane fusion (GO:0000768)8.32106155
7lens development in camera-type eye (GO:0002088)8.29202403
8syncytium formation (GO:0006949)8.01220412
9positive regulation of myotube differentiation (GO:0010831)7.84838741
10actin filament-based movement (GO:0030048)7.84339981
11plasma membrane repair (GO:0001778)7.54802072
12sarcoplasmic reticulum calcium ion transport (GO:0070296)7.27463036
13muscle cell cellular homeostasis (GO:0046716)7.06737151
14positive regulation of skeletal muscle tissue development (GO:0048643)6.75953931
15negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.51694028
16regulation of syncytium formation by plasma membrane fusion (GO:0060142)6.43961856
17response to inactivity (GO:0014854)6.24968596
18skeletal muscle tissue development (GO:0007519)6.14678734
19lens fiber cell development (GO:0070307)6.03210906
20regulation of skeletal muscle contraction (GO:0014819)5.98140266
21sarcomere organization (GO:0045214)5.87785397
22response to muscle activity (GO:0014850)5.85750737
23muscle fiber development (GO:0048747)5.83534846
24plasma membrane fusion (GO:0045026)5.77959635
25response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.64703831
26striated muscle atrophy (GO:0014891)5.54183402
27regulation of relaxation of muscle (GO:1901077)5.53554004
28muscle organ development (GO:0007517)5.45147871
29striated muscle contraction (GO:0006941)5.38667270
30muscle structure development (GO:0061061)5.30227512
31lens fiber cell differentiation (GO:0070306)5.21858031
32positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)5.20762885
33regulation of skeletal muscle cell differentiation (GO:2001014)5.18520235
34negative regulation of potassium ion transmembrane transport (GO:1901380)5.15669685
35negative regulation of cell size (GO:0045792)4.84913295
36* muscle contraction (GO:0006936)4.75506550
37positive regulation of myoblast differentiation (GO:0045663)4.73963413
38myofibril assembly (GO:0030239)4.72498429
39muscle atrophy (GO:0014889)4.71507183
40regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.60917910
41striated muscle cell development (GO:0055002)4.52291978
42actomyosin structure organization (GO:0031032)4.34610965
43endodermal cell differentiation (GO:0035987)4.28375396
44* muscle system process (GO:0003012)4.22297802
45heterotypic cell-cell adhesion (GO:0034113)4.20566585
46neuromuscular synaptic transmission (GO:0007274)4.17965618
47striated muscle tissue development (GO:0014706)4.16025813
48regulation of myotube differentiation (GO:0010830)4.13301721
49creatine metabolic process (GO:0006600)4.09126133
50negative regulation of protein localization to cell surface (GO:2000009)4.07655775
51regulation of myoblast differentiation (GO:0045661)4.06090395
52muscle cell development (GO:0055001)4.01188972
53myotube differentiation (GO:0014902)3.95541231
54muscle adaptation (GO:0043500)3.86713594
55neuromuscular junction development (GO:0007528)3.80766446
56lens morphogenesis in camera-type eye (GO:0002089)3.72871011
57muscle tissue development (GO:0060537)3.70670615
58embryonic camera-type eye development (GO:0031076)3.68954308
59regulation of striated muscle contraction (GO:0006942)3.63733731
60regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.52878455
61positive regulation of striated muscle cell differentiation (GO:0051155)3.50951965
62response to lithium ion (GO:0010226)3.47859125
63regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.47809668
64regulation of p38MAPK cascade (GO:1900744)3.46312572
65cellular response to estradiol stimulus (GO:0071392)3.39965854
66muscle tissue morphogenesis (GO:0060415)3.37337530
67positive regulation of muscle cell differentiation (GO:0051149)3.35448671
68regulation of actin filament-based movement (GO:1903115)3.33681788
69response to activity (GO:0014823)3.31351232
70cardiac muscle hypertrophy (GO:0003300)3.30867411
71regulation of skeletal muscle fiber development (GO:0048742)3.29203554
72regulation of muscle system process (GO:0090257)3.27397939
73glycogen biosynthetic process (GO:0005978)3.25875218
74glucan biosynthetic process (GO:0009250)3.25875218
75striated muscle adaptation (GO:0014888)3.20901448
76positive regulation of astrocyte differentiation (GO:0048711)3.17966687
77regulation of skeletal muscle tissue development (GO:0048641)3.17621061
78glycogen catabolic process (GO:0005980)3.15826026
79response to caffeine (GO:0031000)3.15115575
80skeletal muscle tissue regeneration (GO:0043403)3.14038738
81striated muscle hypertrophy (GO:0014897)3.13183604
82cardiac myofibril assembly (GO:0055003)3.12443356
83face morphogenesis (GO:0060325)3.10389479
84regulation of muscle contraction (GO:0006937)3.06098491
85regulation of calcium ion transmembrane transporter activity (GO:1901019)3.05398975
86regulation of calcium ion transmembrane transport (GO:1903169)3.05398975
87regulation of sarcomere organization (GO:0060297)3.02589656
88positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.98254319
89postsynaptic membrane organization (GO:0001941)2.96876351
90myelin assembly (GO:0032288)2.96081270
91mRNA transcription from RNA polymerase II promoter (GO:0042789)2.95000706
92glucan catabolic process (GO:0009251)2.93704785
93cardiac muscle tissue morphogenesis (GO:0055008)2.92523975
94regulation of cell communication by electrical coupling (GO:0010649)2.91998073
95synaptic transmission, cholinergic (GO:0007271)2.90148735
96skeletal muscle cell differentiation (GO:0035914)2.89352409
97regulation of muscle cell differentiation (GO:0051147)2.87888961
98positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.83291534
99regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.82163138
100embryonic retina morphogenesis in camera-type eye (GO:0060059)2.79706769
101regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.79613834
102skeletal muscle adaptation (GO:0043501)2.79226621
103regulation of striated muscle cell differentiation (GO:0051153)2.79192451
104basement membrane organization (GO:0071711)2.78736904
105cardiac muscle contraction (GO:0060048)2.77476474
106glycoprotein catabolic process (GO:0006516)2.76633395
107muscle hypertrophy (GO:0014896)2.75648286
108positive regulation of p38MAPK cascade (GO:1900745)2.75234599
109epithelial cell-cell adhesion (GO:0090136)2.75092710
110muscle organ morphogenesis (GO:0048644)2.74261589
111negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.71901704
112membrane tubulation (GO:0097320)2.69842905
113cellular polysaccharide catabolic process (GO:0044247)2.69778985
114mRNA transcription (GO:0009299)2.68214347
115response to parathyroid hormone (GO:0071107)2.65231081
116camera-type eye development (GO:0043010)2.63206263
117cardiac muscle cell development (GO:0055013)2.57944834
118cellular response to osmotic stress (GO:0071470)2.53155808
119regulation of membrane repolarization (GO:0060306)2.52031272
120positive regulation of protein depolymerization (GO:1901881)2.51009622
121cardiac cell development (GO:0055006)2.50805263
122positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.50546634
123collagen fibril organization (GO:0030199)2.48278249
124muscle filament sliding (GO:0030049)12.1797144
125actin-myosin filament sliding (GO:0033275)12.1797144
126skeletal muscle fiber development (GO:0048741)11.1087877
127skeletal muscle contraction (GO:0003009)10.7760125
128actin-mediated cell contraction (GO:0070252)10.1322137

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.75515844
2ZNF652_21678463_ChIP-ChIP_ZR75-1_Human3.75015131
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56059857
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.50747565
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.32549105
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.29122871
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.05119757
8VDR_21846776_ChIP-Seq_THP-1_Human3.02838381
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.99447219
10BP1_19119308_ChIP-ChIP_Hs578T_Human2.94917230
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.72228447
12RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.69188254
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.65533298
14GATA1_22025678_ChIP-Seq_K562_Human2.62366147
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.58422153
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.35076239
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11587765
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.06855230
19MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human2.04063404
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03934697
21P68_20966046_ChIP-Seq_HELA_Human2.01138374
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.00707456
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.98186481
24WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97438289
25CLOCK_20551151_ChIP-Seq_293T_Human1.91082190
26LXR_22292898_ChIP-Seq_THP-1_Human1.90117723
27E2F1_20622854_ChIP-Seq_HELA_Human1.87246585
28ELK3_25401928_ChIP-Seq_HUVEC_Human1.81534210
29BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.81061587
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.75322371
31* MAF_26560356_Chip-Seq_TH2_Human1.75290835
32TBX20_22080862_ChIP-Seq_HEART_Mouse1.73699649
33TBX20_22328084_ChIP-Seq_HEART_Mouse1.73699649
34TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.68821826
35SMC1_22415368_ChIP-Seq_MEFs_Mouse1.67460701
36KDM2B_26808549_Chip-Seq_SUP-B15_Human1.65403252
37MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64797480
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.63390149
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.61917618
40MAF_26560356_Chip-Seq_TH1_Human1.60860877
41NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.59564019
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59502810
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.59306032
44CJUN_26792858_Chip-Seq_BT549_Human1.59012672
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.58133730
46ATF3_27146783_Chip-Seq_COLON_Human1.57947977
47TP53_22127205_ChIP-Seq_IMR90_Human1.56383288
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.55254574
49SMC3_22415368_ChIP-Seq_MEFs_Mouse1.54782711
50* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53887158
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52474504
52MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.51181352
53DROSHA_22980978_ChIP-Seq_HELA_Human1.50617274
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.50351699
55EZH2_22144423_ChIP-Seq_EOC_Human1.49849221
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.49609687
57PPAR_26484153_Chip-Seq_NCI-H1993_Human1.48468669
58SMC4_20622854_ChIP-Seq_HELA_Human1.47927631
59KDM2B_26808549_Chip-Seq_DND41_Human1.47345482
60BCL6_27268052_Chip-Seq_Bcells_Human1.45879022
61ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41803369
62* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41737946
63ZFP281_27345836_Chip-Seq_ESCs_Mouse1.41344189
64RACK7_27058665_Chip-Seq_MCF-7_Human1.40065039
65EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39442436
66VDR_24763502_ChIP-Seq_THP-1_Human1.39211133
67KDM2B_26808549_Chip-Seq_K562_Human1.38099259
68RARB_24833708_ChIP-Seq_LIVER_Mouse1.32951938
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.31008861
70TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30914649
71BCOR_27268052_Chip-Seq_Bcells_Human1.30747727
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.30600014
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30463993
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28810834
75* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.28750572
76CTCF_26484167_Chip-Seq_Bcells_Mouse1.28389526
77SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27198196
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25475701
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24773401
80RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24773401
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24297673
82CTCF_27219007_Chip-Seq_Bcells_Human1.23399121
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.23090151
84DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22994722
85* CTCF_21964334_Chip-Seq_Bcells_Human1.21023671
86CREB1_26743006_Chip-Seq_LNCaP_Human1.20616384
87SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20301726
88TCF7_22412390_ChIP-Seq_EML_Mouse1.20269921
89PHF8_20622854_ChIP-Seq_HELA_Human1.20131669
90* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19695919
91SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19141819
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.18740103
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17129393
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.15402836
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.15264545
96* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15174340
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14871876
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14781926
99MYC_22102868_ChIP-Seq_BL_Human1.14399272
100ELF1_20517297_ChIP-Seq_JURKAT_Human1.13299949
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12951015
102MYC_27129775_Chip-Seq_CORNEA_Mouse1.12279118
103RARA_24833708_ChIP-Seq_LIVER_Mouse1.12267358
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09946052
105GATA4_21415370_ChIP-Seq_HL-1_Mouse1.09761471
106KDM2B_26808549_Chip-Seq_JURKAT_Human1.08656473
107OCT4_20526341_ChIP-Seq_ESCs_Human1.08583274
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.08238301
109UTX_26944678_Chip-Seq_JUKART_Human1.07775054
110GATA1_19941827_ChIP-Seq_MEL86_Mouse1.07622459
111TP53_18474530_ChIP-ChIP_U2OS_Human1.06494808
112JARID2_20075857_ChIP-Seq_MESCs_Mouse1.05968686
113STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.05615970
114KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04521412
115TP63_22573176_ChIP-Seq_HFKS_Human1.04253082
116* FOXP1_21924763_ChIP-Seq_HESCs_Human1.03874587
117SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.03397631
118MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02139067
119SPI1_20517297_ChIP-Seq_HL60_Human1.02103433
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02093298
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01459820
122GATA3_24758297_ChIP-Seq_MCF-7_Human1.00640647
123NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00487508
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00267223
125NFE2_27457419_Chip-Seq_LIVER_Mouse1.00223875
126CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99977422
127* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99268770
128RING1B_27294783_Chip-Seq_ESCs_Mouse0.98492098
129CTCF_27219007_Chip-Seq_ERYTHROID_Human0.97393225
130TP53_16413492_ChIP-PET_HCT116_Human0.96692975
131SA1_27219007_Chip-Seq_ERYTHROID_Human0.96580657
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96438716
133BRD4_25478319_ChIP-Seq_HGPS_Human0.95752055
134SA1_27219007_Chip-Seq_Bcells_Human0.95615292
135RUNX1_27514584_Chip-Seq_MCF-7_Human0.94924867
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.94732592
137SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.94724776
138ZNF263_19887448_ChIP-Seq_K562_Human0.94567851
139TP53_23651856_ChIP-Seq_MEFs_Mouse0.94131703
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.93917856
141RNF2_27304074_Chip-Seq_ESCs_Mouse0.93172962
142JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92404080
143JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92089586
144POU5F1_16518401_ChIP-PET_MESCs_Mouse0.91131735
145UBF1/2_26484160_Chip-Seq_HMECs_Human0.91017631
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.84348227
147ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.84327990
148CTNNB1_20460455_ChIP-Seq_HCT116_Human0.83463432
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.83367017

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration7.56016380
2MP0000751_myopathy6.64728304
3MP0000733_abnormal_muscle_development4.66690329
4MP0004145_abnormal_muscle_electrophysio4.45672385
5MP0000750_abnormal_muscle_regeneration4.17686835
6MP0000747_muscle_weakness3.95098495
7* MP0002106_abnormal_muscle_physiology3.51230173
8MP0004270_analgesia3.40292828
9MP0002269_muscular_atrophy3.37435127
10* MP0000759_abnormal_skeletal_muscle3.32642784
11* MP0004087_abnormal_muscle_fiber3.29215111
12MP0002837_dystrophic_cardiac_calcinosis3.14490271
13MP0002697_abnormal_eye_size3.08304293
14* MP0005369_muscle_phenotype3.00661585
15MP0002108_abnormal_muscle_morphology2.42743759
16MP0004233_abnormal_muscle_weight2.42102239
17MP0002249_abnormal_larynx_morphology2.26327818
18MP0004084_abnormal_cardiac_muscle2.14375312
19MP0010030_abnormal_orbit_morphology2.13916756
20MP0005193_abnormal_anterior_eye2.08224789
21MP0005330_cardiomyopathy1.95558067
22MP0005171_absent_coat_pigmentation1.94557277
23MP0008438_abnormal_cutaneous_collagen1.93062253
24MP0005451_abnormal_body_composition1.90771888
25MP0001661_extended_life_span1.86183907
26MP0003950_abnormal_plasma_membrane1.78602581
27MP0002971_abnormal_brown_adipose1.74171626
28MP0005623_abnormal_meninges_morphology1.71636959
29MP0003941_abnormal_skin_development1.70474466
30MP0004036_abnormal_muscle_relaxation1.66651219
31MP0001986_abnormal_taste_sensitivity1.61256939
32MP0005423_abnormal_somatic_nervous1.59370901
33MP0005620_abnormal_muscle_contractility1.58708041
34MP0000767_abnormal_smooth_muscle1.46796063
35MP0001542_abnormal_bone_strength1.42823374
36MP0001346_abnormal_lacrimal_gland1.42758633
37MP0001299_abnormal_eye_distance/1.38928305
38MP0003279_aneurysm1.28726909
39MP0004215_abnormal_myocardial_fiber1.26118239
40MP0010630_abnormal_cardiac_muscle1.25565128
41MP0005083_abnormal_biliary_tract1.17510317
42MP0009250_abnormal_appendicular_skeleto1.11830488
43MP0005503_abnormal_tendon_morphology1.11092277
44MP0001915_intracranial_hemorrhage1.10775409
45MP0003566_abnormal_cell_adhesion1.09905019
46MP0004272_abnormal_basement_membrane1.08490634
47MP0003646_muscle_fatigue1.05129086
48MP0003136_yellow_coat_color1.04313727
49MP0003705_abnormal_hypodermis_morpholog1.03397195
50MP0005197_abnormal_uvea_morphology1.02589107
51MP0002114_abnormal_axial_skeleton1.02103333
52MP0002877_abnormal_melanocyte_morpholog1.01374872
53MP0003879_abnormal_hair_cell1.00308353
54MP0002972_abnormal_cardiac_muscle0.99249209
55MP0002234_abnormal_pharynx_morphology0.98959944
56MP0003091_abnormal_cell_migration0.94810468
57MP0000013_abnormal_adipose_tissue0.94478903
58MP0003385_abnormal_body_wall0.93313225
59MP0005266_abnormal_metabolism0.90887529
60MP0002734_abnormal_mechanical_nocicepti0.89033518
61MP0005248_abnormal_Harderian_gland0.87224542
62MP0001958_emphysema0.87074785
63MP0002127_abnormal_cardiovascular_syste0.86864390
64MP0003942_abnormal_urinary_system0.84425365
65MP0005409_darkened_coat_color0.83451602
66MP0001286_abnormal_eye_development0.83349347
67MP0005275_abnormal_skin_tensile0.79825677
68MP0000516_abnormal_urinary_system0.77975320
69MP0005367_renal/urinary_system_phenotyp0.77975320
70MP0005508_abnormal_skeleton_morphology0.77260037
71MP0004134_abnormal_chest_morphology0.75236041
72MP0003755_abnormal_palate_morphology0.74965167
73MP0004197_abnormal_fetal_growth/weight/0.74647057
74MP0009384_cardiac_valve_regurgitation0.73286506
75MP0006036_abnormal_mitochondrial_physio0.73112813
76MP0002932_abnormal_joint_morphology0.71527592
77MP0009780_abnormal_chondrocyte_physiolo0.70619914
78MP0005257_abnormal_intraocular_pressure0.70015333
79MP0005174_abnormal_tail_pigmentation0.69593288
80MP0001440_abnormal_grooming_behavior0.68699535
81MP0000858_altered_metastatic_potential0.67584596
82MP0005375_adipose_tissue_phenotype0.67047860
83MP0003115_abnormal_respiratory_system0.64950611
84MP0000049_abnormal_middle_ear0.64929627
85MP0008569_lethality_at_weaning0.61850681
86MP0004185_abnormal_adipocyte_glucose0.61314622
87MP0003045_fibrosis0.60995461
88MP0005076_abnormal_cell_differentiation0.60956354
89MP0002092_abnormal_eye_morphology0.60731826
90MP0000762_abnormal_tongue_morphology0.60390172
91MP0000003_abnormal_adipose_tissue0.59163493
92MP0003221_abnormal_cardiomyocyte_apopto0.58362845
93MP0004510_myositis0.57341629
94MP0002896_abnormal_bone_mineralization0.55971229
95MP0004858_abnormal_nervous_system0.55460804
96MP0003137_abnormal_impulse_conducting0.54443172
97MP0003283_abnormal_digestive_organ0.54130617
98MP0002933_joint_inflammation0.53243468
99MP0004484_altered_response_of0.53063797
100MP0006138_congestive_heart_failure0.52181989
101MP0000428_abnormal_craniofacial_morphol0.51082650
102MP0002332_abnormal_exercise_endurance0.47713116
103MP0002128_abnormal_blood_circulation0.47131018
104MP0002160_abnormal_reproductive_system0.47090763
105MP0000266_abnormal_heart_morphology0.46557470
106MP0000163_abnormal_cartilage_morphology0.45451713
107* MP0001943_abnormal_respiration0.44504355
108MP0003828_pulmonary_edema0.43617927
109MP0005023_abnormal_wound_healing0.43302196
110MP0002638_abnormal_pupillary_reflex0.42745709
111MP0001614_abnormal_blood_vessel0.42439845
112MP0000534_abnormal_ureter_morphology0.40704166
113MP0004130_abnormal_muscle_cell0.40336036
114MP0003656_abnormal_erythrocyte_physiolo0.40210312
115MP0005501_abnormal_skin_physiology0.39947050
116MP0005319_abnormal_enzyme/_coenzyme0.39878980
117MP0000432_abnormal_head_morphology0.38505108
118MP0004085_abnormal_heartbeat0.38475851
119MP0002116_abnormal_craniofacial_bone0.38040672
120MP0008775_abnormal_heart_ventricle0.36712564
121* MP0002081_perinatal_lethality0.36612877
122MP0002113_abnormal_skeleton_development0.36526561
123MP0001544_abnormal_cardiovascular_syste0.36402145
124MP0005385_cardiovascular_system_phenoty0.36402145
125MP0005621_abnormal_cell_physiology0.36368073
126MP0003959_abnormal_lean_body0.35637757
127MP0002060_abnormal_skin_morphology0.35041958
128MP0001756_abnormal_urination0.33733326
129MP0008770_decreased_survivor_rate0.32256479
130MP0006276_abnormal_autonomic_nervous0.29740600
131* MP0003948_abnormal_gas_homeostasis0.27930600
132MP0002822_catalepsy0.27338312
133MP0002163_abnormal_gland_morphology0.26798201
134MP0002089_abnormal_postnatal_growth/wei0.26401885
135MP0005584_abnormal_enzyme/coenzyme_acti0.26013767

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)8.11335100
2Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.06455738
3* Fetal akinesia sequence (HP:0001989)7.58363446
4Muscle fiber inclusion bodies (HP:0100299)7.45041799
5Type 1 muscle fiber predominance (HP:0003803)7.38518124
6* Popliteal pterygium (HP:0009756)7.34281010
7Nuclear cataract (HP:0100018)7.14535189
8Type 2 muscle fiber atrophy (HP:0003554)6.52029365
9* Abnormality of placental membranes (HP:0011409)6.31881700
10* Amniotic constriction ring (HP:0009775)6.31881700
11* Aplasia of the musculature (HP:0100854)6.28393586
12Distal arthrogryposis (HP:0005684)5.94957906
13Zonular cataract (HP:0010920)5.92984900
14Muscle fiber atrophy (HP:0100295)5.92614934
15Weak cry (HP:0001612)5.72418970
16Fatigable weakness (HP:0003473)5.71452738
17Abnormality of the neuromuscular junction (HP:0003398)5.71452738
18Round ear (HP:0100830)5.65906340
19* Malignant hyperthermia (HP:0002047)5.65853195
20Ulnar deviation of the wrist (HP:0003049)5.36619456
21Myopathic facies (HP:0002058)4.99940797
22* Akinesia (HP:0002304)4.91881245
23Bulbar palsy (HP:0001283)4.79177370
24Calcaneovalgus deformity (HP:0001848)4.75244448
25Abnormality of skeletal muscle fiber size (HP:0012084)4.48884254
26Gowers sign (HP:0003391)4.42622872
27Deformed tarsal bones (HP:0008119)4.34979257
28Absent phalangeal crease (HP:0006109)3.93461936
29Easy fatigability (HP:0003388)3.90266177
30* Thin ribs (HP:0000883)3.74933156
31Mildly elevated creatine phosphokinase (HP:0008180)3.74456798
32* Pterygium (HP:0001059)3.72041504
33Centrally nucleated skeletal muscle fibers (HP:0003687)3.63659942
34* Aplasia/Hypoplasia involving the musculature (HP:0001460)3.60250509
35Increased variability in muscle fiber diameter (HP:0003557)3.50826925
36EMG: myopathic abnormalities (HP:0003458)3.50494243
37Hip contracture (HP:0003273)3.43413370
38Slender build (HP:0001533)3.42097523
39Generalized muscle weakness (HP:0003324)3.41417113
40Abnormal finger flexion creases (HP:0006143)3.35221334
41Difficulty climbing stairs (HP:0003551)3.30114342
42Abnormality of the calf musculature (HP:0001430)3.21022418
43Scapular winging (HP:0003691)3.16568746
44* Hypoplastic heart (HP:0001961)3.11040837
45Muscle fiber splitting (HP:0003555)3.04282542
46Hyporeflexia of lower limbs (HP:0002600)3.03221995
47Trismus (HP:0000211)3.03185577
48Difficulty running (HP:0009046)3.02948776
49Abnormality of the calcaneus (HP:0008364)3.01060852
50Neck muscle weakness (HP:0000467)2.98710060
51Abnormality of the left ventricular outflow tract (HP:0011103)2.97269341
52Subaortic stenosis (HP:0001682)2.97269341
53* Cystic hygroma (HP:0000476)2.94201986
54Respiratory insufficiency due to muscle weakness (HP:0002747)2.86763771
55Asymmetric septal hypertrophy (HP:0001670)2.73187045
56Poor suck (HP:0002033)2.69867107
57Increased connective tissue (HP:0009025)2.69075396
58Spinal rigidity (HP:0003306)2.65312827
59Distal lower limb amyotrophy (HP:0008944)2.58709612
60Breech presentation (HP:0001623)2.57332843
61Calf muscle hypertrophy (HP:0008981)2.52416867
62Frequent falls (HP:0002359)2.52073149
63Infantile muscular hypotonia (HP:0008947)2.51516859
64Rhabdomyolysis (HP:0003201)2.50206392
65Myoglobinuria (HP:0002913)2.41503274
66Limited hip movement (HP:0008800)2.39169817
67Muscle stiffness (HP:0003552)2.38493428
68Areflexia of lower limbs (HP:0002522)2.34009574
69* Abnormalities of placenta or umbilical cord (HP:0001194)2.32089084
70Exercise-induced myalgia (HP:0003738)2.27402416
71* Diminished movement (HP:0002374)2.24915408
72Mask-like facies (HP:0000298)2.24830131
73EMG: neuropathic changes (HP:0003445)2.22732005
74Muscle hypertrophy of the lower extremities (HP:0008968)2.22386567
75Chin dimple (HP:0010751)2.20047583
76* Arthrogryposis multiplex congenita (HP:0002804)2.19144689
77* Webbed neck (HP:0000465)2.16856424
78Limb-girdle muscle atrophy (HP:0003797)2.13194235
79Metatarsus adductus (HP:0001840)2.09851009
80Rimmed vacuoles (HP:0003805)2.09340592
81Abnormality of the shoulder girdle musculature (HP:0001435)2.07692593
82Nonprogressive disorder (HP:0003680)1.99506472
83Lower limb amyotrophy (HP:0007210)1.98756540
84Thin bony cortex (HP:0002753)1.92345122
85Depressed nasal tip (HP:0000437)1.90532702
86Congenital hip dislocation (HP:0001374)1.86968042
87Facial diplegia (HP:0001349)1.86192014
88Testicular atrophy (HP:0000029)1.84793017
89Congenital cataract (HP:0000519)1.81583693
90Waddling gait (HP:0002515)1.81300921
91Progressive muscle weakness (HP:0003323)1.80782949
92Right ventricular cardiomyopathy (HP:0011663)1.76761301
93Bundle branch block (HP:0011710)1.74000530
94Atrioventricular block (HP:0001678)1.73618713
95Knee flexion contracture (HP:0006380)1.72008407
96Lipoatrophy (HP:0100578)1.71474217
97Heart block (HP:0012722)1.71456305
98Proximal amyotrophy (HP:0007126)1.67419526
99Abnormal atrioventricular conduction (HP:0005150)1.65685299
100Generalized amyotrophy (HP:0003700)1.64711084
101Tarsal synostosis (HP:0008368)1.64515832
102* Rocker bottom foot (HP:0001838)1.64068747
103Hyperkalemia (HP:0002153)1.63143466
104Exercise-induced muscle cramps (HP:0003710)1.63094140
105Ulnar deviation of finger (HP:0009465)1.60772572
106Short palpebral fissure (HP:0012745)1.59898929
107* Vertebral fusion (HP:0002948)1.57382305
108Dilated cardiomyopathy (HP:0001644)1.56882977
109Corneal dystrophy (HP:0001131)1.51836004
110Synostosis involving bones of the feet (HP:0009140)1.50648847
111Synostosis involving bones of the lower limbs (HP:0009138)1.50648847
112Anterior segment dysgenesis (HP:0007700)1.48903502
113Myotonia (HP:0002486)1.46797537
114Distal lower limb muscle weakness (HP:0009053)1.45471359
115Distal upper limb amyotrophy (HP:0007149)1.44268629
116Upper limb amyotrophy (HP:0009129)1.44268629
117Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.42576933
118Hypoplastic ischia (HP:0003175)1.41760971
119Sudden death (HP:0001699)1.40118036
120Abnormal auditory evoked potentials (HP:0006958)1.39257495
121Adducted thumb (HP:0001181)1.36431952
122Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.36040566

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PIK3CG7.07000902
2MUSK6.79161502
3MOS5.52356257
4TRIB35.11796592
5PIM23.09769058
6MAPK152.59989586
7EEF2K2.48137945
8PKN22.40086880
9MAP3K102.23056207
10OBSCN2.12003448
11ICK2.01386571
12CCNB11.96580817
13MAPKAPK31.93663220
14PAK41.79799249
15MAP2K31.70660481
16CDK61.69216154
17ILK1.67247316
18DDR21.57750855
19MAP2K11.53720440
20TRPM71.49428889
21ROCK21.45650354
22TTN1.39526484
23EPHB11.38066919
24CDK141.31356713
25CDK151.29750714
26CDK181.23377293
27CDK11A1.22068121
28DYRK1B1.22046244
29LATS21.18336631
30PDGFRA1.13059627
31MAPK121.06657126
32ROCK11.04362403
33AKT21.03108559
34NME11.02536825
35LRRK21.01812338
36PTK61.00299757
37LATS10.94801814
38MAP2K60.92829866
39FGFR40.90759734
40EPHB20.90636284
41RIPK10.89406077
42PRKG10.88926311
43PTK20.85468258
44BRD40.82131204
45MTOR0.81449749
46PINK10.80990537
47MAP3K50.80263885
48SIK10.79381914
49NEK90.78565430
50MAPK70.73769407
51DAPK30.72622635
52DMPK0.71049419
53TLK10.68409952
54ZAP700.62964887
55MARK20.62178001
56WNK40.62065896
57MAPK110.61711681
58MAP2K40.59573384
59LIMK10.57479053
60SGK10.57364228
61RPS6KB20.56183005
62BCKDK0.54986907
63FLT30.53760033
64RAF10.53176788
65BLK0.51169678
66BMX0.49409873
67PDK20.48762613
68PRKD20.46902844
69MARK10.46395810
70PAK60.46099784
71TYRO30.46096098
72MAP3K60.42665133
73MELK0.42504697
74* RPS6KA30.41180222
75INSR0.40935505
76MAPKAPK20.39904702
77MAPK100.39666382
78ABL20.39179251
79STK100.38689419
80ABL10.36319381
81RPS6KB10.36191896
82CAMK40.35828129
83PRKAA20.35022064
84PTK2B0.34792961
85PRKACB0.33733728
86CAMK2G0.33555062
87FGFR10.33335897
88MAP3K130.32908875
89CAMK2D0.29852957
90NTRK10.29788852
91CDK50.29560507
92SGK30.29521054
93CAMK2A0.29434877
94PAK20.29369731
95FER0.29262403
96FGR0.28108488
97PHKG20.27301990
98PHKG10.27301990
99RPS6KA20.26731094
100MAP3K70.26635135
101ADRBK10.26490096
102PIK3CA0.26168333
103PRKACA0.25943222
104TAOK20.25920210
105STK110.25787782
106RPS6KA60.25136816
107CSNK1D0.25067152
108RPS6KC10.24907948
109RPS6KL10.24907948
110PRKAA10.24596929
111WNK10.23852683
112PDPK10.23277836
113PAK10.22794022
114CDK90.22729836
115PDGFRB0.21931517
116BMPR1B0.21629087
117ALK0.21542558
118CAMK10.21167428
119MET0.21150196
120KSR10.20937037
121STK160.20426980
122PKN10.20179275
123CDK80.18805035
124CAMK2B0.18187212
125MAPK40.17927238
126CDK40.17659973
127RET0.17168034
128TIE10.17137133
129CSNK1E0.17020586
130KSR20.16892436
131RPS6KA10.16756240
132ARAF0.16651855
133TGFBR20.16287955
134RPS6KA50.15762489
135EPHA20.15090362
136ERBB40.14552780
137CDK120.14552693
138MAPK80.14521437
139PAK30.13847970
140HIPK20.12846531
141PRKD10.12825007
142MAPK90.12554140
143CSK0.12442707
144ERBB20.12022044
145PRKCA0.11547570

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054106.08058478
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054125.84538325
3Dilated cardiomyopathy_Homo sapiens_hsa054145.76064669
4Cardiac muscle contraction_Homo sapiens_hsa042602.77876225
5Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.64328356
6Focal adhesion_Homo sapiens_hsa045102.63146241
7ECM-receptor interaction_Homo sapiens_hsa045122.62017631
8Tight junction_Homo sapiens_hsa045302.44938406
9Proteoglycans in cancer_Homo sapiens_hsa052052.07011225
10Viral myocarditis_Homo sapiens_hsa054161.92134435
11Sulfur relay system_Homo sapiens_hsa041221.88946818
12Adherens junction_Homo sapiens_hsa045201.81555477
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.75817931
14Fructose and mannose metabolism_Homo sapiens_hsa000511.75681763
15Bladder cancer_Homo sapiens_hsa052191.67427357
16Oxytocin signaling pathway_Homo sapiens_hsa049211.66611981
17Regulation of actin cytoskeleton_Homo sapiens_hsa048101.57788791
18Chronic myeloid leukemia_Homo sapiens_hsa052201.52083592
19Amoebiasis_Homo sapiens_hsa051461.47965783
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.28846051
21Arginine biosynthesis_Homo sapiens_hsa002201.24724645
22Protein digestion and absorption_Homo sapiens_hsa049741.21978911
23Arginine and proline metabolism_Homo sapiens_hsa003301.17878647
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16841015
25Insulin signaling pathway_Homo sapiens_hsa049101.16535248
26Hippo signaling pathway_Homo sapiens_hsa043901.14385894
27Lysine degradation_Homo sapiens_hsa003101.13490399
28Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05946621
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.05907731
30TGF-beta signaling pathway_Homo sapiens_hsa043501.05871555
31Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.04934942
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04292765
33MAPK signaling pathway_Homo sapiens_hsa040101.03539520
34Nitrogen metabolism_Homo sapiens_hsa009101.02598688
35Basal cell carcinoma_Homo sapiens_hsa052171.02064300
36Small cell lung cancer_Homo sapiens_hsa052221.01973756
37mTOR signaling pathway_Homo sapiens_hsa041501.01679603
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01313477
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.00531715
40Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.99683123
41Glioma_Homo sapiens_hsa052140.98619914
42HIF-1 signaling pathway_Homo sapiens_hsa040660.98584461
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.97631424
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94782258
45Renin secretion_Homo sapiens_hsa049240.93375118
46Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91907114
47MicroRNAs in cancer_Homo sapiens_hsa052060.91297358
48Hedgehog signaling pathway_Homo sapiens_hsa043400.90828081
49FoxO signaling pathway_Homo sapiens_hsa040680.88225163
50Melanoma_Homo sapiens_hsa052180.88208207
51GnRH signaling pathway_Homo sapiens_hsa049120.87990366
52p53 signaling pathway_Homo sapiens_hsa041150.86977834
53Glucagon signaling pathway_Homo sapiens_hsa049220.85635940
54Gastric acid secretion_Homo sapiens_hsa049710.84112287
55VEGF signaling pathway_Homo sapiens_hsa043700.82869830
56Renal cell carcinoma_Homo sapiens_hsa052110.80936354
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80831021
58PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80138755
59Vascular smooth muscle contraction_Homo sapiens_hsa042700.80117240
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78994191
61Notch signaling pathway_Homo sapiens_hsa043300.78864233
62Pancreatic cancer_Homo sapiens_hsa052120.77810177
63Axon guidance_Homo sapiens_hsa043600.77691625
64Ovarian steroidogenesis_Homo sapiens_hsa049130.77554603
65Alcoholism_Homo sapiens_hsa050340.77232897
66Biosynthesis of amino acids_Homo sapiens_hsa012300.75893939
67Prostate cancer_Homo sapiens_hsa052150.75723784
68ErbB signaling pathway_Homo sapiens_hsa040120.75101075
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72927483
70Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72305221
71Systemic lupus erythematosus_Homo sapiens_hsa053220.71401240
72Melanogenesis_Homo sapiens_hsa049160.70821159
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69971346
74Wnt signaling pathway_Homo sapiens_hsa043100.69826203
75AMPK signaling pathway_Homo sapiens_hsa041520.69177526
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68446308
77Long-term potentiation_Homo sapiens_hsa047200.66827416
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66785588
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66772649
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65597467
81Pentose phosphate pathway_Homo sapiens_hsa000300.63328427
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63030380
83Carbon metabolism_Homo sapiens_hsa012000.62952640
84Platelet activation_Homo sapiens_hsa046110.62510128
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61318462
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61165936
87Endometrial cancer_Homo sapiens_hsa052130.61038849
88Pyruvate metabolism_Homo sapiens_hsa006200.60159131
89Renin-angiotensin system_Homo sapiens_hsa046140.58228804
90Acute myeloid leukemia_Homo sapiens_hsa052210.57348626
91Circadian rhythm_Homo sapiens_hsa047100.56700710
92Salivary secretion_Homo sapiens_hsa049700.56668929
93Starch and sucrose metabolism_Homo sapiens_hsa005000.54054629
94Estrogen signaling pathway_Homo sapiens_hsa049150.53807133
95Phototransduction_Homo sapiens_hsa047440.53427320
96* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51669053
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51570930
98Dorso-ventral axis formation_Homo sapiens_hsa043200.51142091
99Pathways in cancer_Homo sapiens_hsa052000.50861730
100Insulin resistance_Homo sapiens_hsa049310.50067387
101Gap junction_Homo sapiens_hsa045400.49971305
102cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49640534
103HTLV-I infection_Homo sapiens_hsa051660.49478293
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.49235531
105Salmonella infection_Homo sapiens_hsa051320.47899718
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.47555436
107Prion diseases_Homo sapiens_hsa050200.47171037
108Colorectal cancer_Homo sapiens_hsa052100.46746574
109Circadian entrainment_Homo sapiens_hsa047130.45255446
110Cholinergic synapse_Homo sapiens_hsa047250.43544618
111Toxoplasmosis_Homo sapiens_hsa051450.43169858
112cAMP signaling pathway_Homo sapiens_hsa040240.41598141
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38383853
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.37503686
115Inositol phosphate metabolism_Homo sapiens_hsa005620.37364118
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37125173
117Calcium signaling pathway_Homo sapiens_hsa040200.36856875
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.36359837
119Non-small cell lung cancer_Homo sapiens_hsa052230.36297160
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34219853
121Apoptosis_Homo sapiens_hsa042100.33888964
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33261850
123Thyroid cancer_Homo sapiens_hsa052160.32576122
124Long-term depression_Homo sapiens_hsa047300.32553767
125Ras signaling pathway_Homo sapiens_hsa040140.31783474
126Alzheimers disease_Homo sapiens_hsa050100.31727556
127Fatty acid degradation_Homo sapiens_hsa000710.31541604
128Prolactin signaling pathway_Homo sapiens_hsa049170.31221399
129Hepatitis B_Homo sapiens_hsa051610.30755774
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30713980
131Phosphatidylinositol signaling system_Homo sapiens_hsa040700.30562749
132Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.30532102
133Endocytosis_Homo sapiens_hsa041440.30266189
134B cell receptor signaling pathway_Homo sapiens_hsa046620.30258408
135Glycosaminoglycan degradation_Homo sapiens_hsa005310.30115466
136Choline metabolism in cancer_Homo sapiens_hsa052310.29769083
137Amphetamine addiction_Homo sapiens_hsa050310.29258944
138Rap1 signaling pathway_Homo sapiens_hsa040150.28689457
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.28080373
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27962262
141Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27935686
142Insulin secretion_Homo sapiens_hsa049110.27752132
143Viral carcinogenesis_Homo sapiens_hsa052030.27415600

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