CHRND

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1muscle filament sliding (GO:0030049)9.72677519
2actin-myosin filament sliding (GO:0033275)9.72677519
3muscle cell fate commitment (GO:0042693)8.75810902
4skeletal muscle fiber development (GO:0048741)8.51318119
5actin-mediated cell contraction (GO:0070252)8.02962087
6myoblast fusion (GO:0007520)7.51606696
7response to muscle activity (GO:0014850)7.47300515
8myotube cell development (GO:0014904)7.45010034
9positive regulation of myotube differentiation (GO:0010831)7.15907668
10syncytium formation by plasma membrane fusion (GO:0000768)6.76894115
11myofibril assembly (GO:0030239)6.61266241
12plasma membrane repair (GO:0001778)6.48073424
13regulation of relaxation of muscle (GO:1901077)6.46073262
14actin filament-based movement (GO:0030048)6.40677299
15syncytium formation (GO:0006949)6.13662569
16muscle cell cellular homeostasis (GO:0046716)5.88120699
17regulation of skeletal muscle contraction (GO:0014819)5.81454712
18proline biosynthetic process (GO:0006561)5.80995633
19sarcoplasmic reticulum calcium ion transport (GO:0070296)5.64488555
20response to inactivity (GO:0014854)5.57249107
21embryonic camera-type eye development (GO:0031076)5.53097469
22transcription from mitochondrial promoter (GO:0006390)5.37548993
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.20805522
24regulation of syncytium formation by plasma membrane fusion (GO:0060142)5.19574450
25response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.18236360
26skeletal muscle tissue development (GO:0007519)5.16520726
27negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.12792162
28positive regulation of protein homooligomerization (GO:0032464)5.12741659
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.00861835
30cardiac myofibril assembly (GO:0055003)4.97059526
31striated muscle atrophy (GO:0014891)4.92091029
32embryonic process involved in female pregnancy (GO:0060136)4.78701962
33striated muscle contraction (GO:0006941)4.69343330
34cardiac muscle contraction (GO:0060048)4.63098233
35muscle fiber development (GO:0048747)4.55867295
36regulation of integrin activation (GO:0033623)4.47559931
37positive regulation of skeletal muscle tissue development (GO:0048643)4.47249616
38muscle organ development (GO:0007517)4.43094937
39oxidative demethylation (GO:0070989)4.40966742
40muscle atrophy (GO:0014889)4.37295674
41regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.36515210
42muscle structure development (GO:0061061)4.32553626
43regulation of striated muscle contraction (GO:0006942)4.27564357
44creatine metabolic process (GO:0006600)4.24588814
45positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.23183992
46regulation of protein homooligomerization (GO:0032462)4.19400585
47proline metabolic process (GO:0006560)4.18669867
48replication fork processing (GO:0031297)4.08755744
49negative regulation of protein localization to cell surface (GO:2000009)4.06654666
50regulation of sarcomere organization (GO:0060297)3.92522611
51muscle adaptation (GO:0043500)3.89773746
52* muscle contraction (GO:0006936)3.88311032
53regulation of skeletal muscle fiber development (GO:0048742)3.86281739
54striated muscle cell development (GO:0055002)3.79523041
55neuromuscular synaptic transmission (GO:0007274)3.76367224
56positive regulation of myoblast differentiation (GO:0045663)3.75611118
57* musculoskeletal movement (GO:0050881)3.69892911
58* multicellular organismal movement (GO:0050879)3.69892911
59negative regulation of potassium ion transmembrane transport (GO:1901380)3.69092760
60striated muscle tissue development (GO:0014706)3.66729008
61cardiac muscle hypertrophy (GO:0003300)3.64805747
62sarcomere organization (GO:0045214)3.63527956
63positive regulation of protein oligomerization (GO:0032461)3.61036659
64regulation of actin filament-based movement (GO:1903115)3.54400306
65glycogen catabolic process (GO:0005980)3.53165362
66regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.49976931
67regulation of myotube differentiation (GO:0010830)3.49303332
68myotube differentiation (GO:0014902)3.48052167
69striated muscle hypertrophy (GO:0014897)3.45647969
70skeletal muscle tissue regeneration (GO:0043403)3.43811649
71* muscle system process (GO:0003012)3.41900962
72poly(A)+ mRNA export from nucleus (GO:0016973)3.39741277
73muscle tissue morphogenesis (GO:0060415)3.38787090
74membrane tubulation (GO:0097320)3.36801997
75postsynaptic membrane organization (GO:0001941)3.33675302
76muscle cell development (GO:0055001)3.33181278
77regulation of muscle system process (GO:0090257)3.31683562
78glucan biosynthetic process (GO:0009250)3.29466903
79glycogen biosynthetic process (GO:0005978)3.29466903
80glucan catabolic process (GO:0009251)3.28284832
81establishment of apical/basal cell polarity (GO:0035089)3.27298346
82cardiac muscle cell development (GO:0055013)3.26286746
83negative regulation of JAK-STAT cascade (GO:0046426)3.23692145
84regulation of skeletal muscle cell differentiation (GO:2001014)3.22037026
85muscle tissue development (GO:0060537)3.22029549
86positive regulation of microtubule polymerization (GO:0031116)3.21967322
87regulation of myoblast differentiation (GO:0045661)3.21717257
88positive regulation of receptor recycling (GO:0001921)3.19833836
89response to activity (GO:0014823)3.13809819
90glial cell migration (GO:0008347)3.11925915
91skeletal muscle adaptation (GO:0043501)3.11763035
92plasma membrane fusion (GO:0045026)3.09640175
93regulation of calcium ion transmembrane transporter activity (GO:1901019)3.07455829
94regulation of calcium ion transmembrane transport (GO:1903169)3.07455829
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05887892
96cardiac cell development (GO:0055006)3.04945591
97muscle hypertrophy (GO:0014896)3.04815017
98negative regulation of chondrocyte differentiation (GO:0032331)3.04524930
99regulation of muscle contraction (GO:0006937)3.02814314
100cellular polysaccharide catabolic process (GO:0044247)3.01831749
101cellular response to ATP (GO:0071318)3.00904085
102positive regulation of mitotic sister chromatid separation (GO:1901970)3.00409757
103positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.00409757
104positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.00409757
105embryonic placenta development (GO:0001892)2.99930166
106auditory receptor cell stereocilium organization (GO:0060088)2.99483536
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.99050660
108DNA integration (GO:0015074)2.98983261
109positive regulation of striated muscle cell differentiation (GO:0051155)2.97195108
110regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.97078973
111synaptic transmission, cholinergic (GO:0007271)2.96251099
112regulation of protein oligomerization (GO:0032459)2.95862285
113striated muscle adaptation (GO:0014888)2.94887452
114regulation of striated muscle cell differentiation (GO:0051153)2.94225352
115mitochondrial DNA metabolic process (GO:0032042)2.94045503
116negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.93594885
117skeletal muscle cell differentiation (GO:0035914)2.93523641
118regulation of membrane repolarization (GO:0060306)2.93520479
119actomyosin structure organization (GO:0031032)2.92124923
120establishment of monopolar cell polarity (GO:0061162)2.90537664
121establishment or maintenance of monopolar cell polarity (GO:0061339)2.90537664
122negative regulation of muscle hypertrophy (GO:0014741)2.90179485
123cardiac muscle tissue morphogenesis (GO:0055008)2.90003255
124mRNA transcription (GO:0009299)2.88476717
125response to caffeine (GO:0031000)2.88079144
126negative regulation of potassium ion transport (GO:0043267)2.87738061
127regulation of skeletal muscle tissue development (GO:0048641)2.83336053
128response to dexamethasone (GO:0071548)2.82990781
129positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.82734376
130response to lithium ion (GO:0010226)2.81156213
131regulation of translational fidelity (GO:0006450)2.78444133
132regulation of potassium ion transmembrane transporter activity (GO:1901016)2.77642865
133cellular response to dexamethasone stimulus (GO:0071549)2.76385811
134activation of Rac GTPase activity (GO:0032863)2.76287613
135response to parathyroid hormone (GO:0071107)2.75946247
136DNA demethylation (GO:0080111)2.75883935
137regulation of muscle cell differentiation (GO:0051147)2.75014843
138neuromuscular junction development (GO:0007528)2.73031679
139positive regulation of muscle cell differentiation (GO:0051149)2.72513852
140convergent extension (GO:0060026)2.71648974
141mRNA transcription from RNA polymerase II promoter (GO:0042789)2.71531661
142signal complex assembly (GO:0007172)2.70327956
143regulation of cAMP-dependent protein kinase activity (GO:2000479)2.67701932
144regulation of cell communication by electrical coupling (GO:0010649)2.65319274
145DNA strand renaturation (GO:0000733)2.60706164
146negative regulation of cell size (GO:0045792)2.60398363
147positive regulation of developmental pigmentation (GO:0048087)2.59507662
148cell migration in hindbrain (GO:0021535)2.58316785
149skeletal muscle contraction (GO:0003009)10.2056483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.74743490
2SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.70611245
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.21606960
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.16914881
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.16914881
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.16914881
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.88362371
8GATA1_22025678_ChIP-Seq_K562_Human2.81986244
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.66798250
10NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.55924751
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.51153323
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.45784683
13POU5F1_16518401_ChIP-PET_MESCs_Mouse2.40742883
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.35193757
15ERG_21242973_ChIP-ChIP_JURKAT_Human2.15962807
16MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.12607095
17TP53_20018659_ChIP-ChIP_R1E_Mouse2.07850367
18LXR_22292898_ChIP-Seq_THP-1_Human2.05895593
19ZNF263_19887448_ChIP-Seq_K562_Human2.03716217
20* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.94692459
21MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.91635971
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90416526
23ZFP281_27345836_Chip-Seq_ESCs_Mouse1.90242979
24TRIM28_21343339_ChIP-Seq_HEK293_Human1.89663364
25DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.87451847
26TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86446986
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85875904
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.83749311
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80030779
30NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.79405251
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.79008628
32* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.75572608
33EZH2_27294783_Chip-Seq_ESCs_Mouse1.72982519
34BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.72896981
35P68_20966046_ChIP-Seq_HELA_Human1.72891251
36NFIB_24661679_ChIP-Seq_LUNG_Mouse1.71557927
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.67488527
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.64524665
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62853287
40EZH2_22144423_ChIP-Seq_EOC_Human1.61612879
41EP300_21415370_ChIP-Seq_HL-1_Mouse1.61224298
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.59942865
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.59914453
44* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58663103
45STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58604398
46RACK7_27058665_Chip-Seq_MCF-7_Human1.57192461
47TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57160337
48HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.52597260
49CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.48479376
50E2F1_20622854_ChIP-Seq_HELA_Human1.48388999
51NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47591311
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46484787
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.44283816
54* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43933792
55NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.43297346
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.42494392
57VDR_21846776_ChIP-Seq_THP-1_Human1.42319121
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40536670
59TP53_23651856_ChIP-Seq_MEFs_Mouse1.40315317
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.39325445
61* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39253331
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37461494
63SA1_27219007_Chip-Seq_ERYTHROID_Human1.35600375
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34767797
65DROSHA_22980978_ChIP-Seq_HELA_Human1.34373987
66* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.33000146
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31100740
68PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30860407
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29310961
70SMC4_20622854_ChIP-Seq_HELA_Human1.28242681
71PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.27303001
72CTCF_27219007_Chip-Seq_Bcells_Human1.26575154
73* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26081930
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25554949
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25450537
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.25391038
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.24058664
78KDM2B_26808549_Chip-Seq_K562_Human1.23349191
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.22287254
80NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21408216
81SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21004387
82* CTCF_26484167_Chip-Seq_Bcells_Mouse1.19099233
83OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.18516353
84TP53_22127205_ChIP-Seq_IMR90_Human1.18436279
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16375639
86CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13117673
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12940344
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11165054
89RXRA_24833708_ChIP-Seq_LIVER_Mouse1.09875110
90EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09635784
91RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09635784
92* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.08887077
93* TCF7_22412390_ChIP-Seq_EML_Mouse1.07536569
94KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06973803
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06964954
96ETS1_21867929_ChIP-Seq_TH2_Mouse1.06867235
97CREB1_26743006_Chip-Seq_LNCaP_Human1.06758155
98ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05304959
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04825905
100NANOG_21062744_ChIP-ChIP_HESCs_Human1.04783809
101JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03989080
102KDM2B_26808549_Chip-Seq_DND41_Human1.02556638
103SOX11_22085726_ChIP-Seq_ESNs_Mouse1.02509179
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02230536
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02133095
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.02082450
107YY1_22570637_ChIP-Seq_MALME-3M_Human1.01929139
108OCT4_20526341_ChIP-Seq_ESCs_Human1.01652589
109* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01378807
110MAF_26560356_Chip-Seq_TH2_Human1.01199597
111TP63_22573176_ChIP-Seq_HFKS_Human1.01030556
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00646088
113KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00626112
114RARB_24833708_ChIP-Seq_LIVER_Mouse0.99897347
115NANOG_16518401_ChIP-PET_MESCs_Mouse0.99163565
116TBX20_22328084_ChIP-Seq_HEART_Mouse0.98831148
117TBX20_22080862_ChIP-Seq_HEART_Mouse0.98831148
118RNF2_27304074_Chip-Seq_ESCs_Mouse0.98048299
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.97963811
120* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97920474
121TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97900092
122ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.97426632
123ELF1_20517297_ChIP-Seq_JURKAT_Human0.97174987
124PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96655544
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.96620536
126KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96324406
127BCL6_27268052_Chip-Seq_Bcells_Human0.95773914
128TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95753417
129PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95627551
130OCT4_19829295_ChIP-Seq_ESCs_Human0.94328753
131FOXP1_21924763_ChIP-Seq_HESCs_Human0.94227049
132RUNX1_27514584_Chip-Seq_MCF-7_Human0.93812272
133EZH2_27304074_Chip-Seq_ESCs_Mouse0.92683909
134PCGF2_27294783_Chip-Seq_NPCs_Mouse0.92313761
135GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92010711
136SPI1_26923725_Chip-Seq_HPCs_Mouse0.91903803
137UBF1/2_26484160_Chip-Seq_HMECs_Human0.90449164
138SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.89471536
139STAT1_20625510_ChIP-Seq_HELA_Human0.88395879
140NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.87808045
141NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87473956
142WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87367420
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.87306810
144CTCF_21964334_Chip-Seq_Bcells_Human0.87054302
145MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.86831420
146STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85923804
147SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.85516305
148SA1_27219007_Chip-Seq_Bcells_Human0.85397193
149MYC_27129775_Chip-Seq_CORNEA_Mouse0.84252415
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83465514
151POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82631533
152CJUN_26792858_Chip-Seq_BT549_Human0.81433253
153POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.79312709
154NFYA_21822215_ChIP-Seq_K562_Human0.78805586
155GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78111485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy5.80040283
2MP0000749_muscle_degeneration5.73453835
3MP0000733_abnormal_muscle_development4.29104206
4MP0004145_abnormal_muscle_electrophysio4.14084327
5MP0000750_abnormal_muscle_regeneration3.81351240
6MP0010030_abnormal_orbit_morphology3.70237756
7MP0002106_abnormal_muscle_physiology3.65354218
8MP0004233_abnormal_muscle_weight3.43344880
9MP0002269_muscular_atrophy3.31553744
10MP0000759_abnormal_skeletal_muscle3.28589841
11MP0000747_muscle_weakness3.18831203
12MP0005369_muscle_phenotype3.12409037
13MP0004087_abnormal_muscle_fiber2.96909649
14MP0005171_absent_coat_pigmentation2.89073160
15MP0002249_abnormal_larynx_morphology2.56365632
16MP0002108_abnormal_muscle_morphology2.55642867
17MP0008057_abnormal_DNA_replication2.42451757
18MP0004270_analgesia2.41326687
19MP0002837_dystrophic_cardiac_calcinosis2.35896747
20MP0005451_abnormal_body_composition2.04558440
21MP0003950_abnormal_plasma_membrane1.98709520
22MP0004130_abnormal_muscle_cell1.98416607
23MP0003941_abnormal_skin_development1.78309758
24MP0005330_cardiomyopathy1.73370235
25MP0004484_altered_response_of1.65509065
26MP0002971_abnormal_brown_adipose1.52678983
27MP0001661_extended_life_span1.49312155
28MP0009278_abnormal_bone_marrow1.47759818
29MP0005423_abnormal_somatic_nervous1.41806548
30MP0003136_yellow_coat_color1.38181652
31MP0002114_abnormal_axial_skeleton1.36986725
32MP0001346_abnormal_lacrimal_gland1.34411638
33MP0005620_abnormal_muscle_contractility1.34084096
34MP0001542_abnormal_bone_strength1.29409450
35MP0000516_abnormal_urinary_system1.23901060
36MP0005367_renal/urinary_system_phenotyp1.23901060
37MP0001986_abnormal_taste_sensitivity1.23261568
38MP0002932_abnormal_joint_morphology1.21248656
39MP0005623_abnormal_meninges_morphology1.17104446
40MP0003755_abnormal_palate_morphology1.14665551
41MP0004084_abnormal_cardiac_muscle1.14462499
42MP0000013_abnormal_adipose_tissue1.12862546
43MP0000762_abnormal_tongue_morphology1.12646021
44MP0002009_preneoplasia1.09744072
45MP0005248_abnormal_Harderian_gland1.06401105
46MP0003646_muscle_fatigue1.06027608
47MP0010630_abnormal_cardiac_muscle1.05047446
48MP0003137_abnormal_impulse_conducting1.04761768
49MP0005503_abnormal_tendon_morphology1.04358941
50MP0003385_abnormal_body_wall1.03548496
51MP0002822_catalepsy1.03104492
52MP0004134_abnormal_chest_morphology1.02570413
53MP0004197_abnormal_fetal_growth/weight/1.01323754
54MP0003879_abnormal_hair_cell1.01166503
55MP0009250_abnormal_appendicular_skeleto0.99190313
56MP0005508_abnormal_skeleton_morphology0.98451604
57MP0006036_abnormal_mitochondrial_physio0.98336558
58MP0004215_abnormal_myocardial_fiber0.97990040
59MP0004510_myositis0.97827080
60MP0004133_heterotaxia0.97052416
61MP0005275_abnormal_skin_tensile0.95028889
62MP0005645_abnormal_hypothalamus_physiol0.93891544
63MP0003453_abnormal_keratinocyte_physiol0.93650679
64MP0008995_early_reproductive_senescence0.92718618
65MP0005083_abnormal_biliary_tract0.92642978
66MP0003566_abnormal_cell_adhesion0.92491431
67MP0005385_cardiovascular_system_phenoty0.91815232
68MP0001544_abnormal_cardiovascular_syste0.91815232
69MP0004036_abnormal_muscle_relaxation0.90473940
70MP0008438_abnormal_cutaneous_collagen0.86798813
71MP0003942_abnormal_urinary_system0.83619912
72MP0002127_abnormal_cardiovascular_syste0.81230295
73MP0002734_abnormal_mechanical_nocicepti0.78912012
74MP0003705_abnormal_hypodermis_morpholog0.77461914
75MP0003045_fibrosis0.76858917
76MP0000049_abnormal_middle_ear0.76742239
77MP0005375_adipose_tissue_phenotype0.75496334
78MP0003828_pulmonary_edema0.74962282
79MP0000767_abnormal_smooth_muscle0.74653050
80MP0006138_congestive_heart_failure0.73852879
81MP0001545_abnormal_hematopoietic_system0.73645203
82MP0005397_hematopoietic_system_phenotyp0.73645203
83MP0002116_abnormal_craniofacial_bone0.73526324
84MP0002282_abnormal_trachea_morphology0.73221397
85MP0000003_abnormal_adipose_tissue0.73024479
86MP0000579_abnormal_nail_morphology0.71608527
87MP0002184_abnormal_innervation0.68635488
88MP0005076_abnormal_cell_differentiation0.68311639
89MP0003935_abnormal_craniofacial_develop0.66171058
90MP0002084_abnormal_developmental_patter0.65880622
91MP0002332_abnormal_exercise_endurance0.65003661
92MP0002234_abnormal_pharynx_morphology0.64985379
93MP0003119_abnormal_digestive_system0.64963799
94MP0001943_abnormal_respiration0.64854718
95MP0006072_abnormal_retinal_apoptosis0.64503321
96MP0008877_abnormal_DNA_methylation0.63681549
97MP0002085_abnormal_embryonic_tissue0.63174792
98MP0003221_abnormal_cardiomyocyte_apopto0.61938593
99MP0005501_abnormal_skin_physiology0.61729057
100MP0003718_maternal_effect0.60816109
101MP0000432_abnormal_head_morphology0.60409581
102MP0001299_abnormal_eye_distance/0.60277242
103MP0000266_abnormal_heart_morphology0.60272029
104MP0002972_abnormal_cardiac_muscle0.60258376
105MP0004858_abnormal_nervous_system0.59641312
106MP0001440_abnormal_grooming_behavior0.59610283
107MP0000678_abnormal_parathyroid_gland0.58060454
108MP0005266_abnormal_metabolism0.58029041
109MP0003786_premature_aging0.57897121
110MP0002060_abnormal_skin_morphology0.57494673
111MP0003091_abnormal_cell_migration0.57384706
112MP0000955_abnormal_spinal_cord0.55892861
113MP0004185_abnormal_adipocyte_glucose0.55511671
114MP0004381_abnormal_hair_follicle0.55064909
115MP0001340_abnormal_eyelid_morphology0.53883828
116MP0003279_aneurysm0.52022309
117MP0002163_abnormal_gland_morphology0.50184257
118MP0002111_abnormal_tail_morphology0.49253862
119MP0010094_abnormal_chromosome_stability0.48832036
120MP0002081_perinatal_lethality0.48597062
121MP0002638_abnormal_pupillary_reflex0.48497566
122MP0001915_intracranial_hemorrhage0.48113441
123MP0008058_abnormal_DNA_repair0.48011386
124MP0002086_abnormal_extraembryonic_tissu0.47693906
125MP0003948_abnormal_gas_homeostasis0.46220106
126MP0002896_abnormal_bone_mineralization0.45786423
127MP0000534_abnormal_ureter_morphology0.45648222
128MP0004272_abnormal_basement_membrane0.44357814
129MP0005409_darkened_coat_color0.43696626
130MP0004085_abnormal_heartbeat0.43655091
131MP0003806_abnormal_nucleotide_metabolis0.42538790
132MP0003122_maternal_imprinting0.41936000
133MP0005174_abnormal_tail_pigmentation0.40461579
134MP0008775_abnormal_heart_ventricle0.39739819
135MP0005670_abnormal_white_adipose0.38513101
136MP0000372_irregular_coat_pigmentation0.35963362
137MP0002938_white_spotting0.31434535
138MP0006276_abnormal_autonomic_nervous0.31056151
139MP0005452_abnormal_adipose_tissue0.30849889
140MP0002128_abnormal_blood_circulation0.30558936
141MP0009672_abnormal_birth_weight0.30505560
142MP0003959_abnormal_lean_body0.28654475
143MP0009384_cardiac_valve_regurgitation0.28095532
144MP0008770_decreased_survivor_rate0.27859368
145MP0005666_abnormal_adipose_tissue0.27077778
146MP0001756_abnormal_urination0.25313608

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.05109026
2Nemaline bodies (HP:0003798)8.04939108
3* Fetal akinesia sequence (HP:0001989)7.69695655
4Muscle fiber inclusion bodies (HP:0100299)7.65199282
5* Popliteal pterygium (HP:0009756)7.37145953
6Type 1 muscle fiber predominance (HP:0003803)7.04842507
7* Aplasia of the musculature (HP:0100854)6.74380728
8* Amniotic constriction ring (HP:0009775)6.35334425
9* Abnormality of placental membranes (HP:0011409)6.35334425
10Distal arthrogryposis (HP:0005684)6.31278287
11* Malignant hyperthermia (HP:0002047)6.01582967
12Round ear (HP:0100830)5.75682709
13Myopathic facies (HP:0002058)5.24288314
14Ulnar deviation of the wrist (HP:0003049)5.20655008
15* Type 2 muscle fiber atrophy (HP:0003554)5.13467651
16Calcaneovalgus deformity (HP:0001848)4.91287313
17* Muscle fiber atrophy (HP:0100295)4.59240294
18Deformed tarsal bones (HP:0008119)4.56895360
19* Fatigable weakness (HP:0003473)4.47274884
20* Abnormality of the neuromuscular junction (HP:0003398)4.47274884
21* Akinesia (HP:0002304)4.47221738
22* Weak cry (HP:0001612)4.18292129
23* Bulbar palsy (HP:0001283)3.92201758
24Absent phalangeal crease (HP:0006109)3.89010596
25* Aplasia/Hypoplasia involving the musculature (HP:0001460)3.83816306
26* Thin ribs (HP:0000883)3.80046704
27Rib fusion (HP:0000902)3.71925764
28Abnormality of skeletal muscle fiber size (HP:0012084)3.66782227
29Long clavicles (HP:0000890)3.63033281
30* Gowers sign (HP:0003391)3.49723692
31Hip contracture (HP:0003273)3.48010450
32* Pterygium (HP:0001059)3.41176705
33Mildly elevated creatine phosphokinase (HP:0008180)3.34088782
34Exercise-induced myalgia (HP:0003738)3.30129036
35EMG: myopathic abnormalities (HP:0003458)3.26047589
36Neck muscle weakness (HP:0000467)3.25187486
37Abnormal finger flexion creases (HP:0006143)3.24002954
38Difficulty climbing stairs (HP:0003551)3.23374795
39* Hypoplastic heart (HP:0001961)3.23165433
40Abnormality of the calf musculature (HP:0001430)3.20988470
41* Cystic hygroma (HP:0000476)3.18495611
42Difficulty running (HP:0009046)3.08914749
43Hyporeflexia of lower limbs (HP:0002600)3.07142694
44Neonatal respiratory distress (HP:0002643)3.07088455
45Abnormality of the calcaneus (HP:0008364)3.02338583
46Abnormality of the left ventricular outflow tract (HP:0011103)3.02315645
47Subaortic stenosis (HP:0001682)3.02315645
48Slender build (HP:0001533)2.94283320
49Asymmetric septal hypertrophy (HP:0001670)2.93032622
50Increased variability in muscle fiber diameter (HP:0003557)2.92393932
51Muscle fiber splitting (HP:0003555)2.91695973
52* Easy fatigability (HP:0003388)2.91591850
53Sudden death (HP:0001699)2.88794477
54Symphalangism affecting the phalanges of the hand (HP:0009773)2.87690009
55Myoglobinuria (HP:0002913)2.78227031
56Trismus (HP:0000211)2.76957318
57Alopecia of scalp (HP:0002293)2.75930077
58Rhabdomyolysis (HP:0003201)2.74491085
59Calf muscle hypertrophy (HP:0008981)2.71326885
60Rimmed vacuoles (HP:0003805)2.69426808
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.68471560
62Areflexia of lower limbs (HP:0002522)2.64417554
63Muscle stiffness (HP:0003552)2.64362461
64Increased connective tissue (HP:0009025)2.61473285
65* Diminished movement (HP:0002374)2.59468857
66Breech presentation (HP:0001623)2.55079215
67Muscle hypertrophy of the lower extremities (HP:0008968)2.46905866
68Scapular winging (HP:0003691)2.45388391
69Limited hip movement (HP:0008800)2.41989487
70* Generalized muscle weakness (HP:0003324)2.41501772
71* Respiratory insufficiency due to muscle weakness (HP:0002747)2.35410909
72Distal lower limb amyotrophy (HP:0008944)2.34413886
73Frequent falls (HP:0002359)2.33980612
74Congenital hip dislocation (HP:0001374)2.33312916
75EMG: neuropathic changes (HP:0003445)2.32890211
76Nonprogressive disorder (HP:0003680)2.32351419
77Spinal rigidity (HP:0003306)2.29589444
78* Abnormalities of placenta or umbilical cord (HP:0001194)2.22860338
79* Webbed neck (HP:0000465)2.18989328
80Fused cervical vertebrae (HP:0002949)2.17207308
81* Arthrogryposis multiplex congenita (HP:0002804)2.08661776
82Metatarsus adductus (HP:0001840)2.05173648
83Chin dimple (HP:0010751)2.04354794
84Hypoplastic nipples (HP:0002557)1.98324552
85Mask-like facies (HP:0000298)1.97268384
86Adducted thumb (HP:0001181)1.89137193
87Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.87720841
88* Vertebral fusion (HP:0002948)1.86961362
89Distal lower limb muscle weakness (HP:0009053)1.86653557
90Bundle branch block (HP:0011710)1.85571683
91Rocker bottom foot (HP:0001838)1.85135355
92Hypoplastic ischia (HP:0003175)1.84285870
93Abnormality of the shoulder girdle musculature (HP:0001435)1.83358674
94Vertebral clefting (HP:0008428)1.82967362
95Hyperkalemia (HP:0002153)1.77553666
96Exercise-induced muscle cramps (HP:0003710)1.73518447
97Abnormality of the labia majora (HP:0012881)1.72813190
98Waddling gait (HP:0002515)1.71871754
99Lower limb amyotrophy (HP:0007210)1.71490110
100Progressive muscle weakness (HP:0003323)1.70027698
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69862251
102Lipoatrophy (HP:0100578)1.69422967
103Muscular dystrophy (HP:0003560)1.69158454
104Limb-girdle muscle atrophy (HP:0003797)1.66133648
105Depressed nasal tip (HP:0000437)1.64676351
106Short palpebral fissure (HP:0012745)1.64598241
107Nasal speech (HP:0001611)1.63614953
108Dilated cardiomyopathy (HP:0001644)1.62764338
109Facial diplegia (HP:0001349)1.62206891
110Patellar aplasia (HP:0006443)1.62080753
111Myotonia (HP:0002486)1.60193244
112Knee flexion contracture (HP:0006380)1.58904047
113Infantile muscular hypotonia (HP:0008947)1.53708164
114Generalized amyotrophy (HP:0003700)1.52738977
115Ulnar deviation of finger (HP:0009465)1.52531712
116Abnormality of the ischium (HP:0003174)1.51826904
117Aplasia/Hypoplasia of the patella (HP:0006498)1.51754525
118Tarsal synostosis (HP:0008368)1.51649745
119Flexion contracture of toe (HP:0005830)1.50708112
120Joint contractures involving the joints of the feet (HP:0100492)1.50708112

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK5.48624981
2PIK3CG4.38336757
3ICK4.09719540
4MOS4.02254208
5DDR23.81547595
6PIM23.67817455
7MAP3K63.43463718
8PINK12.96018150
9OBSCN2.93501507
10TRIB32.51081695
11MAPK152.40153151
12MAP3K111.96699125
13TRPM71.93689610
14BRD41.89326528
15CCNB11.87784368
16CDK61.80297047
17MAP3K71.78809846
18PDK21.78603955
19FGR1.73619539
20TYRO31.72380129
21DYRK1B1.61354588
22BMX1.56020909
23PRKD21.54618644
24PDGFRA1.53858383
25MATK1.53630052
26SIK31.52802317
27LATS21.48032614
28YES11.38835213
29PRPF4B1.35701259
30LIMK11.33211149
31MAP3K101.31633386
32CSK1.20941386
33PHKG11.14351584
34PHKG21.14351584
35MAPK111.12364709
36EPHA21.12192831
37LATS11.09797335
38NME11.08253469
39MAP2K11.07934428
40MARK11.05971619
41SIK11.03929709
42PAK41.03919201
43CDK81.01092562
44UHMK10.99296193
45AKT20.97736469
46PIM10.96758311
47CDK120.96151641
48DAPK10.95418141
49TTN0.93632975
50TAOK20.92675803
51MAP2K30.91874033
52MAPKAPK30.91192148
53CDK70.91075200
54CDK150.90992063
55MAP3K130.89937642
56CDK180.89003073
57FGFR40.88125853
58CDK11A0.84084583
59RPS6KL10.82616340
60RPS6KC10.82616340
61CDK140.79440588
62MAPK70.78938688
63ILK0.73370529
64WNK40.72456675
65RPS6KA60.69819509
66PRKAA10.68139296
67ARAF0.65827531
68CAMK2G0.64024143
69ERBB30.63598574
70DMPK0.63204738
71KSR20.61998114
72STK38L0.61891259
73MTOR0.60031193
74MARK20.59861531
75MAP2K40.59235233
76STK160.59042279
77MAP3K50.58089373
78PDPK10.55395111
79SIK20.55303163
80ROCK20.55053499
81PRKD30.54230657
82CHEK20.54118570
83CDK190.52494332
84MAPK120.51035348
85STK30.50268298
86AKT30.49499216
87NEK90.48319688
88RIPK10.46511580
89CAMK2A0.44456674
90ROCK10.43240368
91CDC42BPA0.42874594
92PAK60.40980004
93RPS6KB20.40220294
94SGK10.39183027
95MAP3K90.38851394
96EPHA30.38133125
97RPS6KA10.36077250
98RPS6KB10.35442370
99EPHB10.35403193
100MAPK100.34403204
101PKN20.33005448
102RAF10.32473015
103PRKAA20.31586580
104* RPS6KA30.30359396
105* PRKG10.28674304
106GSK3A0.27455197
107PBK0.26991034
108HIPK20.26430655
109ABL10.25856434
110MET0.25459977
111MAPKAPK20.24974526
112CDK20.23607158
113CAMK40.23217983
114STK110.22701590
115CAMK2D0.22537922
116PRKACA0.22533481
117PKN10.22411518
118MAPK140.22403080
119PDK10.22353569
120AKT10.22059210
121PRKACB0.21561756
122MELK0.21462825
123MAPK40.21437541
124MAPK10.21315147
125STK390.21224210
126INSR0.20877365
127MAPK130.20160827
128PLK10.20022577
129PIK3CA0.19231102
130MAP3K10.18983844
131SGK30.18843974
132NEK10.18805528
133CDK10.18658105
134PTK20.18392855
135MAPK30.18281399
136CSNK1D0.18125407
137MAP2K60.17564799
138EEF2K0.17179738
139WNK10.16678894
140CAMK2B0.15986579
141TIE10.15917862
142BRAF0.15458104
143MST1R0.15383439
144PRKD10.13757907
145CAMK10.13182084
146PRKG20.12786137
147TLK10.12642108
148BCKDK0.12370437

Predicted pathways (KEGG)

RankGene SetZ-score
1Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054124.30257378
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.17436207
3Dilated cardiomyopathy_Homo sapiens_hsa054143.86494269
4Fatty acid biosynthesis_Homo sapiens_hsa000613.71885102
5Base excision repair_Homo sapiens_hsa034102.63867181
6Circadian rhythm_Homo sapiens_hsa047102.22515622
7Adherens junction_Homo sapiens_hsa045202.17229590
8Tight junction_Homo sapiens_hsa045302.06169462
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.00614029
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99452562
11Notch signaling pathway_Homo sapiens_hsa043301.93195201
12Viral myocarditis_Homo sapiens_hsa054161.92676885
13Sulfur relay system_Homo sapiens_hsa041221.88290963
14Hippo signaling pathway_Homo sapiens_hsa043901.87317358
15mTOR signaling pathway_Homo sapiens_hsa041501.80030344
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.79315677
17Cardiac muscle contraction_Homo sapiens_hsa042601.74891138
18Focal adhesion_Homo sapiens_hsa045101.74883066
19Bladder cancer_Homo sapiens_hsa052191.66373685
20p53 signaling pathway_Homo sapiens_hsa041151.65782863
21Regulation of actin cytoskeleton_Homo sapiens_hsa048101.63459100
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.60536383
23Hedgehog signaling pathway_Homo sapiens_hsa043401.58940109
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58256256
25Mismatch repair_Homo sapiens_hsa034301.57832472
26Longevity regulating pathway - mammal_Homo sapiens_hsa042111.40449082
27Carbon metabolism_Homo sapiens_hsa012001.37297187
28TGF-beta signaling pathway_Homo sapiens_hsa043501.35743083
29Protein digestion and absorption_Homo sapiens_hsa049741.35331317
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31947087
31Insulin resistance_Homo sapiens_hsa049311.28741867
32Arginine biosynthesis_Homo sapiens_hsa002201.26503645
33Wnt signaling pathway_Homo sapiens_hsa043101.25485240
34MAPK signaling pathway_Homo sapiens_hsa040101.24486124
35Pyruvate metabolism_Homo sapiens_hsa006201.23952238
36Proteoglycans in cancer_Homo sapiens_hsa052051.23868693
37Basal cell carcinoma_Homo sapiens_hsa052171.20610689
38Pentose phosphate pathway_Homo sapiens_hsa000301.20264777
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.19414525
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16513189
41Oxytocin signaling pathway_Homo sapiens_hsa049211.14547422
42Chronic myeloid leukemia_Homo sapiens_hsa052201.11930094
43Arginine and proline metabolism_Homo sapiens_hsa003301.10491881
44Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09880038
45mRNA surveillance pathway_Homo sapiens_hsa030151.08824509
46Nitrogen metabolism_Homo sapiens_hsa009101.08068907
47ErbB signaling pathway_Homo sapiens_hsa040121.07685339
48Melanoma_Homo sapiens_hsa052181.05372817
49MicroRNAs in cancer_Homo sapiens_hsa052061.04693249
50Insulin signaling pathway_Homo sapiens_hsa049101.02191836
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99736603
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96370832
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.95886504
54Cell cycle_Homo sapiens_hsa041100.95869447
55ECM-receptor interaction_Homo sapiens_hsa045120.95511601
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.95054864
57Adipocytokine signaling pathway_Homo sapiens_hsa049200.93184253
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92941554
59Shigellosis_Homo sapiens_hsa051310.91317291
60Gastric acid secretion_Homo sapiens_hsa049710.90197848
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89570490
62Renin secretion_Homo sapiens_hsa049240.88475557
63Dorso-ventral axis formation_Homo sapiens_hsa043200.87010920
64Nucleotide excision repair_Homo sapiens_hsa034200.86524446
65Axon guidance_Homo sapiens_hsa043600.82656221
66* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81823509
67Colorectal cancer_Homo sapiens_hsa052100.80997001
68GnRH signaling pathway_Homo sapiens_hsa049120.80901895
69Biosynthesis of amino acids_Homo sapiens_hsa012300.79305057
70Choline metabolism in cancer_Homo sapiens_hsa052310.77829942
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76668735
72VEGF signaling pathway_Homo sapiens_hsa043700.75290224
73Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75021483
74Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.75019473
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74894598
76Fanconi anemia pathway_Homo sapiens_hsa034600.74294112
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73798926
78FoxO signaling pathway_Homo sapiens_hsa040680.73072141
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72773245
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72673508
81Gap junction_Homo sapiens_hsa045400.71170091
82PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71056355
83Melanogenesis_Homo sapiens_hsa049160.70933965
84Pancreatic cancer_Homo sapiens_hsa052120.70512752
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70222292
86AMPK signaling pathway_Homo sapiens_hsa041520.69564101
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69302871
88HIF-1 signaling pathway_Homo sapiens_hsa040660.69274861
89Prostate cancer_Homo sapiens_hsa052150.68797630
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68021785
91Fructose and mannose metabolism_Homo sapiens_hsa000510.67913361
92DNA replication_Homo sapiens_hsa030300.66843394
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66331737
94Homologous recombination_Homo sapiens_hsa034400.65776261
95RNA transport_Homo sapiens_hsa030130.63575523
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62550255
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62277953
98Alzheimers disease_Homo sapiens_hsa050100.61997275
99Acute myeloid leukemia_Homo sapiens_hsa052210.61241168
100Circadian entrainment_Homo sapiens_hsa047130.60757466
101Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60160251
102Salivary secretion_Homo sapiens_hsa049700.58852570
103Glucagon signaling pathway_Homo sapiens_hsa049220.58766238
104Calcium signaling pathway_Homo sapiens_hsa040200.58508907
105Lysine degradation_Homo sapiens_hsa003100.56600211
106Fatty acid degradation_Homo sapiens_hsa000710.56546733
107Endometrial cancer_Homo sapiens_hsa052130.56272417
108Small cell lung cancer_Homo sapiens_hsa052220.54209357
109Long-term potentiation_Homo sapiens_hsa047200.54113238
110Long-term depression_Homo sapiens_hsa047300.52065168
111Salmonella infection_Homo sapiens_hsa051320.51904325
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.51471028
113HTLV-I infection_Homo sapiens_hsa051660.51102235
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50961207
115Hepatitis B_Homo sapiens_hsa051610.49756919
116Glioma_Homo sapiens_hsa052140.48989997
117Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47660033
118Ovarian steroidogenesis_Homo sapiens_hsa049130.46096789
119Starch and sucrose metabolism_Homo sapiens_hsa005000.45976843
120Non-small cell lung cancer_Homo sapiens_hsa052230.45663826
121cAMP signaling pathway_Homo sapiens_hsa040240.41509797
122Fatty acid metabolism_Homo sapiens_hsa012120.39696831
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.39261523
124Thyroid cancer_Homo sapiens_hsa052160.38294768
125Oocyte meiosis_Homo sapiens_hsa041140.38189178
126Insulin secretion_Homo sapiens_hsa049110.37931039
127Amoebiasis_Homo sapiens_hsa051460.36835479
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36263351
129Nicotine addiction_Homo sapiens_hsa050330.36097244
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35680369
131Pathways in cancer_Homo sapiens_hsa052000.34522522
132Cholinergic synapse_Homo sapiens_hsa047250.34455183
133Apoptosis_Homo sapiens_hsa042100.34048264
134Phototransduction_Homo sapiens_hsa047440.34008529
135Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33912786
136Galactose metabolism_Homo sapiens_hsa000520.33761743
137Propanoate metabolism_Homo sapiens_hsa006400.32848780
138Ras signaling pathway_Homo sapiens_hsa040140.32718103
139Phenylalanine metabolism_Homo sapiens_hsa003600.32401061
140Parkinsons disease_Homo sapiens_hsa050120.30903796
141Rap1 signaling pathway_Homo sapiens_hsa040150.30786062
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.30752692
143Leukocyte transendothelial migration_Homo sapiens_hsa046700.29898908
144Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.29113600
145RNA degradation_Homo sapiens_hsa030180.28740281
146Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28166665
147Inositol phosphate metabolism_Homo sapiens_hsa005620.27993533
148Vascular smooth muscle contraction_Homo sapiens_hsa042700.24292057

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »