CHRNA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung cancer. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurotransmitter catabolic process (GO:0042135)6.83969154
2behavioral response to ethanol (GO:0048149)6.77383025
3catecholamine biosynthetic process (GO:0042423)6.62462342
4catechol-containing compound biosynthetic process (GO:0009713)6.62462342
5catecholamine transport (GO:0051937)6.60280850
6norepinephrine metabolic process (GO:0042415)6.43572580
7cell migration in hindbrain (GO:0021535)6.27695306
8dopamine metabolic process (GO:0042417)6.17397087
9negative regulation of microtubule polymerization (GO:0031115)5.93125116
10* synaptic transmission, cholinergic (GO:0007271)5.78921976
11short-term memory (GO:0007614)5.72517734
12dopamine biosynthetic process (GO:0042416)5.52515179
13ganglion development (GO:0061548)5.21227182
14enteric nervous system development (GO:0048484)5.02508569
15dopaminergic neuron differentiation (GO:0071542)5.02371106
16maternal behavior (GO:0042711)4.99534792
17regulation of respiratory gaseous exchange (GO:0043576)4.75460743
18positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.66849470
19alkaloid metabolic process (GO:0009820)4.57801695
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52312380
21catecholamine metabolic process (GO:0006584)4.51025971
22catechol-containing compound metabolic process (GO:0009712)4.51025971
23response to pain (GO:0048265)4.46318084
24neurotransmitter biosynthetic process (GO:0042136)4.41446268
25positive regulation of glomerulus development (GO:0090193)4.36894468
26regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.36144550
27positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.31033162
28parental behavior (GO:0060746)4.29221401
29response to water (GO:0009415)4.28761907
30prepulse inhibition (GO:0060134)4.25510562
31regulation of cardioblast proliferation (GO:0003264)4.23522442
32regulation of secondary heart field cardioblast proliferation (GO:0003266)4.23522442
33cellular response to nicotine (GO:0071316)4.22294486
34* neuromuscular synaptic transmission (GO:0007274)4.18901292
35negative regulation of dendrite morphogenesis (GO:0050774)4.16143388
36regulation of short-term neuronal synaptic plasticity (GO:0048172)4.10977253
37proline transport (GO:0015824)4.03582419
38phenol-containing compound biosynthetic process (GO:0046189)3.89572192
39collecting duct development (GO:0072044)3.87643786
40mating behavior (GO:0007617)3.87239959
41response to amphetamine (GO:0001975)3.84855827
42monoamine transport (GO:0015844)3.81013609
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.76486371
44tongue development (GO:0043586)3.69527664
45regulation of respiratory system process (GO:0044065)3.66975151
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.64573984
47neurotransmitter secretion (GO:0007269)3.63607938
48transmission of nerve impulse (GO:0019226)3.63562197
49dopamine transport (GO:0015872)3.60796444
50negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.57334268
51auditory behavior (GO:0031223)3.55832170
52positive regulation of transcription regulatory region DNA binding (GO:2000679)3.49455717
53cardiac ventricle formation (GO:0003211)3.43595395
54cerebellar granule cell differentiation (GO:0021707)3.41941782
55neuron cell-cell adhesion (GO:0007158)3.41391043
56positive regulation of neurotransmitter transport (GO:0051590)3.38561118
57neurotransmitter metabolic process (GO:0042133)3.34628486
58cellular response to nerve growth factor stimulus (GO:1990090)3.34279332
59response to nerve growth factor (GO:1990089)3.34279332
60regulation of vesicle fusion (GO:0031338)3.33746068
61neurotransmitter transport (GO:0006836)3.33437922
62negative regulation of striated muscle cell apoptotic process (GO:0010664)3.33290599
63synaptic transmission, glutamatergic (GO:0035249)3.33132005
64primary amino compound metabolic process (GO:1901160)3.32859042
65regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.32766159
66regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.32766159
67innervation (GO:0060384)3.30397310
68nucleobase catabolic process (GO:0046113)3.29957467
69adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.29266097
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.28501594
71coronary vasculature morphogenesis (GO:0060977)3.27787719
72neuron-neuron synaptic transmission (GO:0007270)3.27242142
73multi-organism reproductive behavior (GO:0044705)3.25490724
74response to histamine (GO:0034776)3.25385048
75cardiac chamber formation (GO:0003207)3.25005376
76peripheral nervous system neuron development (GO:0048935)3.24495154
77synaptic vesicle exocytosis (GO:0016079)3.24139486
78adult walking behavior (GO:0007628)3.23975315
79metanephric nephron tubule development (GO:0072234)3.23917628
80metanephric tubule development (GO:0072170)3.23917628
81negative regulation of dendrite development (GO:2000171)3.23895692
82cerebellar Purkinje cell layer development (GO:0021680)3.17675379
83glutamate receptor signaling pathway (GO:0007215)3.17649109
84cartilage morphogenesis (GO:0060536)3.16896407
85detection of temperature stimulus involved in sensory perception (GO:0050961)3.15603451
86detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.15603451
87peristalsis (GO:0030432)3.15208434
88protein neddylation (GO:0045116)3.12958973
89* regulation of neurotransmitter transport (GO:0051588)3.09543631
90positive regulation of dendritic spine morphogenesis (GO:0061003)3.07864495
91cell differentiation in hindbrain (GO:0021533)3.07817313
92retinal cone cell development (GO:0046549)3.07431424
93toxin metabolic process (GO:0009404)3.07252001
94neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.06898143
95detection of temperature stimulus (GO:0016048)3.05990154
96reproductive behavior (GO:0019098)3.04943611
97cellular response to prostaglandin stimulus (GO:0071379)3.02865137
98positive regulation of potassium ion transmembrane transport (GO:1901381)3.02260099
99fear response (GO:0042596)3.02210980
100central nervous system neuron axonogenesis (GO:0021955)3.00223312
101regulation of neurotransmitter levels (GO:0001505)2.99536950
102cell migration involved in heart development (GO:0060973)2.99524390
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99106574
104mechanosensory behavior (GO:0007638)2.97977226
105* regulation of neurotransmitter secretion (GO:0046928)2.97562651
106dendrite development (GO:0016358)2.95070971
107regulation of centriole replication (GO:0046599)2.93382109
108* response to nicotine (GO:0035094)2.93182532
109regulation of dopamine secretion (GO:0014059)2.91758730
110axonal fasciculation (GO:0007413)2.91535570
111G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.91505630
112protein localization to synapse (GO:0035418)2.91435181
113regulation of glomerulus development (GO:0090192)2.91037294
114negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91008874
115calcium-mediated signaling using intracellular calcium source (GO:0035584)2.90834686
116substrate-independent telencephalic tangential migration (GO:0021826)2.88741420
117substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.88741420
118dopamine receptor signaling pathway (GO:0007212)2.87286413
119response to amine (GO:0014075)2.86783416
120neuron recognition (GO:0008038)2.86481925
121oxygen transport (GO:0015671)2.84032571
122multicellular organismal reproductive behavior (GO:0033057)2.81978346
123positive regulation of protein depolymerization (GO:1901881)2.80836527
124regulation of synaptic vesicle exocytosis (GO:2000300)2.80575359
125multicellular organismal response to stress (GO:0033555)2.80500753
126pyrimidine nucleobase catabolic process (GO:0006208)2.80443569
127negative regulation of catecholamine secretion (GO:0033604)2.78548592
128ATP synthesis coupled proton transport (GO:0015986)2.78236036
129energy coupled proton transport, down electrochemical gradient (GO:0015985)2.78236036
130positive regulation of cell cycle G2/M phase transition (GO:1902751)2.77200772
131positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.77200772
132response to insecticide (GO:0017085)2.76382401
133metanephric nephron epithelium development (GO:0072243)2.75646552
134regulation of microtubule polymerization (GO:0031113)2.74774759
135gamma-aminobutyric acid transport (GO:0015812)2.72296941
136positive regulation of vesicle fusion (GO:0031340)2.72121306
137C4-dicarboxylate transport (GO:0015740)2.71931575
138spinal cord motor neuron differentiation (GO:0021522)2.71768773
139retina layer formation (GO:0010842)2.71514066
140neurofilament cytoskeleton organization (GO:0060052)2.69359483
141presynaptic membrane organization (GO:0097090)2.67962075
142metanephric epithelium development (GO:0072207)2.67149325
143alanine transport (GO:0032328)2.66554902
144protein heterotetramerization (GO:0051290)2.66254141
145synapse assembly (GO:0007416)2.64665441
146cerebellar Purkinje cell differentiation (GO:0021702)2.64609524
147mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.63888393
148layer formation in cerebral cortex (GO:0021819)2.63796124
149regulation of synaptic transmission, dopaminergic (GO:0032225)2.63698231
150behavioral response to cocaine (GO:0048148)2.63669024
151cranial nerve development (GO:0021545)2.60101957
152cochlea development (GO:0090102)2.56573405
153response to auditory stimulus (GO:0010996)2.55993823
154* adult behavior (GO:0030534)2.53854898
155retinal ganglion cell axon guidance (GO:0031290)2.51282137
156positive regulation of synaptic transmission, GABAergic (GO:0032230)2.48619839
157exploration behavior (GO:0035640)2.48605341
158central nervous system neuron differentiation (GO:0021953)2.46122060
159suckling behavior (GO:0001967)2.44934496
160mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.44619335
161positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.44619335
162phenol-containing compound catabolic process (GO:0019336)13.8030935
163sympathetic nervous system development (GO:0048485)10.5477450
164* behavioral response to nicotine (GO:0035095)10.3158255

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.34099895
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.33737275
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.10789680
4JARID2_20075857_ChIP-Seq_MESCs_Mouse2.98414006
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95936038
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.95214310
7NR3C1_23031785_ChIP-Seq_PC12_Mouse2.83171331
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79472622
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.78908042
10GBX2_23144817_ChIP-Seq_PC3_Human2.71424162
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.67192631
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.64910893
13TAF15_26573619_Chip-Seq_HEK293_Human2.64906916
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60713663
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60713663
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60328576
17RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56891608
18REST_21632747_ChIP-Seq_MESCs_Mouse2.56229470
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.56148888
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.44113715
21ERG_21242973_ChIP-ChIP_JURKAT_Human2.39071740
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.38108642
23* REST_18959480_ChIP-ChIP_MESCs_Mouse2.28556891
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.24141976
25* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17904763
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12141760
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.11672706
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.06338774
29IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01429256
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97879210
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95663057
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.88648109
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87055283
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.85479547
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.79897917
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.74176353
37BCAT_22108803_ChIP-Seq_LS180_Human1.69218549
38CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.65105006
39WT1_19549856_ChIP-ChIP_CCG9911_Human1.63100350
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.55383772
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.53949410
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49328813
43P300_19829295_ChIP-Seq_ESCs_Human1.47239142
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.46991945
45TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46899896
46E2F7_22180533_ChIP-Seq_HELA_Human1.46848380
47OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.44025093
48GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.43906228
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43681732
50FUS_26573619_Chip-Seq_HEK293_Human1.41636851
51STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.41580097
52RNF2_27304074_Chip-Seq_NSC_Mouse1.41132723
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39979810
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.39230250
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35587782
56SMAD4_21799915_ChIP-Seq_A2780_Human1.31856390
57PIAS1_25552417_ChIP-Seq_VCAP_Human1.31348223
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30931734
59* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.30457946
60AR_21572438_ChIP-Seq_LNCaP_Human1.29658223
61EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28608962
62IRF1_19129219_ChIP-ChIP_H3396_Human1.27550432
63AR_25329375_ChIP-Seq_VCAP_Human1.27453478
64SOX2_16153702_ChIP-ChIP_HESCs_Human1.25185518
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22413303
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.21397626
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20863517
68POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19473599
69TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19473599
70IGF1R_20145208_ChIP-Seq_DFB_Human1.18974363
71HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18656653
72JUN_21703547_ChIP-Seq_K562_Human1.18380760
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.17076980
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.16348587
75RING1B_27294783_Chip-Seq_ESCs_Mouse1.14609761
76ZNF274_21170338_ChIP-Seq_K562_Hela1.14364956
77RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13530358
78CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12729391
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.12540687
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.12455293
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11437113
82* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.10878128
83MYC_18940864_ChIP-ChIP_HL60_Human1.10061612
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08620956
85POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07906543
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.06704594
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.04605240
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02811508
89SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01783346
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.01555559
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01325864
92ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01019961
93SOX9_26525672_Chip-Seq_HEART_Mouse0.99655024
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.98995334
95ZNF263_19887448_ChIP-Seq_K562_Human0.98946584
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98938159
97RUNX2_22187159_ChIP-Seq_PCA_Human0.98875158
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98572394
99POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98179286
100SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98049679
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97529641
102YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97274399
103EWS_26573619_Chip-Seq_HEK293_Human0.97139502
104KLF5_20875108_ChIP-Seq_MESCs_Mouse0.96631741
105PRDM14_20953172_ChIP-Seq_ESCs_Human0.95838330
106POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.95558289
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95427438
108TCF4_23295773_ChIP-Seq_U87_Human0.95135501
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94933622
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94607332
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.94047063
112KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.92746211
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91926359
114RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88897852
115VDR_22108803_ChIP-Seq_LS180_Human0.88568520
116KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.87884291
117EST1_17652178_ChIP-ChIP_JURKAT_Human0.87429751
118FLI1_21867929_ChIP-Seq_TH2_Mouse0.85237975
119MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85095872
120TAL1_26923725_Chip-Seq_HPCs_Mouse0.84349839
121FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.83892854
122* CTCF_27219007_Chip-Seq_Bcells_Human0.83610029
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.82792863
124REST_19997604_ChIP-ChIP_NEURONS_Mouse0.80452028
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80094865
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80001764
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78562416
128CBP_20019798_ChIP-Seq_JUKART_Human0.78562416
129EP300_21415370_ChIP-Seq_HL-1_Mouse0.78296273
130STAT3_23295773_ChIP-Seq_U87_Human0.78133293
131ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.75601027

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy9.60313191
2* MP0010386_abnormal_urinary_bladder3.92276642
3* MP0002638_abnormal_pupillary_reflex3.51706558
4MP0006276_abnormal_autonomic_nervous3.25829560
5MP0001905_abnormal_dopamine_level3.22416544
6MP0004270_analgesia3.18387324
7MP0002751_abnormal_autonomic_nervous2.95978534
8MP0001529_abnormal_vocalization2.72309989
9MP0009745_abnormal_behavioral_response2.66556638
10MP0002734_abnormal_mechanical_nocicepti2.60422398
11MP0004858_abnormal_nervous_system2.47994937
12MP0001440_abnormal_grooming_behavior2.38710416
13MP0003011_delayed_dark_adaptation2.35358220
14MP0002733_abnormal_thermal_nociception2.27839506
15MP0003567_abnormal_fetal_cardiomyocyte2.26684781
16MP0001970_abnormal_pain_threshold2.16207764
17* MP0003635_abnormal_synaptic_transmissio2.13670311
18MP0004742_abnormal_vestibular_system2.13443473
19* MP0000538_abnormal_urinary_bladder2.09330887
20MP0000778_abnormal_nervous_system1.97028397
21MP0004859_abnormal_synaptic_plasticity1.93792182
22MP0002572_abnormal_emotion/affect_behav1.92892745
23MP0008872_abnormal_physiological_respon1.90212601
24MP0002064_seizures1.89845334
25MP0003122_maternal_imprinting1.88722173
26MP0002184_abnormal_innervation1.80572125
27MP0002063_abnormal_learning/memory/cond1.77633754
28MP0001968_abnormal_touch/_nociception1.75640306
29MP0005386_behavior/neurological_phenoty1.75328151
30MP0004924_abnormal_behavior1.75328151
31MP0008789_abnormal_olfactory_epithelium1.72882774
32MP0005423_abnormal_somatic_nervous1.65545212
33MP0005645_abnormal_hypothalamus_physiol1.64233535
34MP0003890_abnormal_embryonic-extraembry1.63983358
35MP0005394_taste/olfaction_phenotype1.63722754
36MP0005499_abnormal_olfactory_system1.63722754
37MP0001501_abnormal_sleep_pattern1.59051628
38MP0002735_abnormal_chemical_nociception1.56678539
39MP0003787_abnormal_imprinting1.55867000
40MP0006292_abnormal_olfactory_placode1.55415028
41MP0009379_abnormal_foot_pigmentation1.52221158
42MP0003880_abnormal_central_pattern1.43732655
43MP0002127_abnormal_cardiovascular_syste1.43283193
44MP0000751_myopathy1.43123053
45MP0002909_abnormal_adrenal_gland1.42845246
46MP0000372_irregular_coat_pigmentation1.42139210
47* MP0002272_abnormal_nervous_system1.40152784
48MP0009046_muscle_twitch1.30683193
49MP0002067_abnormal_sensory_capabilities1.29727404
50MP0000955_abnormal_spinal_cord1.25695461
51MP0003136_yellow_coat_color1.25109472
52MP0000534_abnormal_ureter_morphology1.20549902
53* MP0005197_abnormal_uvea_morphology1.19675606
54MP0004811_abnormal_neuron_physiology1.16942399
55MP0002837_dystrophic_cardiac_calcinosis1.14044047
56MP0002557_abnormal_social/conspecific_i1.11604358
57MP0002736_abnormal_nociception_after1.11330177
58MP0002882_abnormal_neuron_morphology1.10145011
59MP0003123_paternal_imprinting1.09092622
60MP0008877_abnormal_DNA_methylation1.08909802
61MP0006035_abnormal_mitochondrial_morpho1.07742824
62MP0008569_lethality_at_weaning1.07682425
63MP0004142_abnormal_muscle_tone1.06485984
64MP0000631_abnormal_neuroendocrine_gland1.05682632
65MP0005646_abnormal_pituitary_gland1.04225413
66MP0002009_preneoplasia1.03350732
67MP0003633_abnormal_nervous_system1.02125515
68MP0002163_abnormal_gland_morphology1.01670710
69MP0003631_nervous_system_phenotype1.00829189
70MP0002152_abnormal_brain_morphology0.99995893
71MP0002752_abnormal_somatic_nervous0.99815149
72MP0003937_abnormal_limbs/digits/tail_de0.97340584
73MP0002066_abnormal_motor_capabilities/c0.96540623
74MP0000049_abnormal_middle_ear0.95949216
75MP0006072_abnormal_retinal_apoptosis0.95814486
76MP0005391_vision/eye_phenotype0.92162335
77MP0003279_aneurysm0.90264864
78MP0003942_abnormal_urinary_system0.87810383
79MP0002938_white_spotting0.85644791
80MP0002069_abnormal_eating/drinking_beha0.83471253
81MP0005171_absent_coat_pigmentation0.83167553
82MP0002102_abnormal_ear_morphology0.82873705
83MP0001486_abnormal_startle_reflex0.80871194
84MP0008874_decreased_physiological_sensi0.80682537
85MP0001299_abnormal_eye_distance/0.77405731
86MP0005195_abnormal_posterior_eye0.75463608
87MP0000427_abnormal_hair_cycle0.74340871
88MP0003632_abnormal_nervous_system0.74210179
89MP0005253_abnormal_eye_physiology0.73394791
90MP0001188_hyperpigmentation0.72396593
91MP0004085_abnormal_heartbeat0.71704576
92MP0008058_abnormal_DNA_repair0.71511115
93MP0005083_abnormal_biliary_tract0.71144267
94MP0005187_abnormal_penis_morphology0.70659763
95MP0003698_abnormal_male_reproductive0.69624336
96MP0001984_abnormal_olfaction0.69177877
97MP0005389_reproductive_system_phenotype0.68527131
98MP0001664_abnormal_digestion0.68512573
99MP0002210_abnormal_sex_determination0.67700632
100MP0004145_abnormal_muscle_electrophysio0.67433303
101MP0001485_abnormal_pinna_reflex0.67310939
102MP0003137_abnormal_impulse_conducting0.67280460
103MP0005551_abnormal_eye_electrophysiolog0.67243617
104MP0001348_abnormal_lacrimal_gland0.65587902
105MP0010094_abnormal_chromosome_stability0.65105504
106MP0010030_abnormal_orbit_morphology0.64519863
107MP0002160_abnormal_reproductive_system0.64502390
108* MP0001270_distended_abdomen0.64414593
109MP0003861_abnormal_nervous_system0.64095411
110MP0005535_abnormal_body_temperature0.63497191
111MP0008932_abnormal_embryonic_tissue0.63401499
112MP0004133_heterotaxia0.63123817
113MP0000566_synostosis0.61979192
114MP0003638_abnormal_response/metabolism_0.60858306
115MP0002653_abnormal_ependyma_morphology0.60516819
116MP0001943_abnormal_respiration0.60499317
117MP0003953_abnormal_hormone_level0.60229364
118MP0001502_abnormal_circadian_rhythm0.59238617
119MP0002233_abnormal_nose_morphology0.57815839
120MP0003121_genomic_imprinting0.57428819
121MP0005408_hypopigmentation0.56833545
122MP0004883_abnormal_blood_vessel0.56522367
123MP0006138_congestive_heart_failure0.56137420
124MP0000003_abnormal_adipose_tissue0.55772450
125MP0002332_abnormal_exercise_endurance0.54081674
126MP0002090_abnormal_vision0.51193422

Predicted human phenotypes

RankGene SetZ-score
1Orthostatic hypotension (HP:0001278)8.43165189
2Abnormal autonomic nervous system physiology (HP:0012332)6.78258707
3Neonatal hypoglycemia (HP:0001998)6.07630955
4Myokymia (HP:0002411)5.48707095
5Limb dystonia (HP:0002451)5.27916219
6Amblyopia (HP:0000646)5.05800478
7Agitation (HP:0000713)4.44469943
8Exotropia (HP:0000577)4.38024447
9Hypoventilation (HP:0002791)4.34581503
10Hyperthyroidism (HP:0000836)4.16686736
11Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.98980681
12Autoamputation (HP:0001218)3.80327470
13Hypotension (HP:0002615)3.73807574
14Epileptic encephalopathy (HP:0200134)3.58995860
15Impaired vibration sensation in the lower limbs (HP:0002166)3.34699670
16Asymmetry of the thorax (HP:0001555)3.33535947
17Impulsivity (HP:0100710)3.17833227
18Focal seizures (HP:0007359)3.10545812
19Focal motor seizures (HP:0011153)3.09770243
20Intestinal atresia (HP:0011100)3.08911428
21Pheochromocytoma (HP:0002666)3.02864348
22Abnormality of the phalanges of the 2nd finger (HP:0009541)2.95482719
23Degeneration of the lateral corticospinal tracts (HP:0002314)2.93961081
24Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.93961081
25Gaze-evoked nystagmus (HP:0000640)2.87853227
26Impaired pain sensation (HP:0007328)2.86841441
27Abnormality of pain sensation (HP:0010832)2.86841441
28Arthropathy (HP:0003040)2.86383836
29Broad-based gait (HP:0002136)2.83434066
30External ophthalmoplegia (HP:0000544)2.80115696
31Hypercortisolism (HP:0001578)2.80053209
32Esophageal atresia (HP:0002032)2.75220188
33Dysdiadochokinesis (HP:0002075)2.73372634
34Neuroendocrine neoplasm (HP:0100634)2.71497344
35Abnormality of calcium-phosphate metabolism (HP:0100530)2.70672565
36Postural tremor (HP:0002174)2.70561477
37Supernumerary spleens (HP:0009799)2.66163686
38Progressive cerebellar ataxia (HP:0002073)2.65588720
39Menstrual irregularities (HP:0000858)2.63180004
40Acute necrotizing encephalopathy (HP:0006965)2.62768816
41Recurrent corneal erosions (HP:0000495)2.55643388
42Poor suck (HP:0002033)2.54531954
43Action tremor (HP:0002345)2.54424021
44Restlessness (HP:0000711)2.51133185
45Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.50047583
46Neuroblastoma (HP:0003006)2.50047583
47Primitive neuroectodermal tumor (HP:0030065)2.50047583
48Neuroblastic tumors (HP:0004376)2.50047583
49Atonic seizures (HP:0010819)2.48513160
50Anxiety (HP:0000739)2.47352043
51Nephrogenic diabetes insipidus (HP:0009806)2.42364308
52Scanning speech (HP:0002168)2.42042687
53Abnormal pupillary function (HP:0007686)2.40341432
54Morphological abnormality of the middle ear (HP:0008609)2.39791635
55Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.39640379
56Myotonia (HP:0002486)2.39387749
57Thyroid carcinoma (HP:0002890)2.35946433
58Congenital primary aphakia (HP:0007707)2.34511469
59Aplasia/Hypoplasia of the spleen (HP:0010451)2.33567658
60Visual hallucinations (HP:0002367)2.32247860
61Dysmetric saccades (HP:0000641)2.29910316
62Medial flaring of the eyebrow (HP:0010747)2.29139811
63Abnormal pancreas size (HP:0012094)2.28227665
64Mitochondrial inheritance (HP:0001427)2.27753978
65Progressive macrocephaly (HP:0004481)2.25737592
66Abnormal mitochondria in muscle tissue (HP:0008316)2.25352667
67Failure to thrive in infancy (HP:0001531)2.24677014
68Horizontal nystagmus (HP:0000666)2.24215888
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22629623
70Annular pancreas (HP:0001734)2.21284843
71Generalized tonic-clonic seizures (HP:0002069)2.19892982
72Growth hormone excess (HP:0000845)2.17926345
73Termporal pattern (HP:0011008)2.17776606
74Insidious onset (HP:0003587)2.17776606
75Abnormality of the parathyroid morphology (HP:0011766)2.17139446
76Abnormality of the corticospinal tract (HP:0002492)2.16915430
77Intention tremor (HP:0002080)2.15313297
78Glossoptosis (HP:0000162)2.14459675
79Breast hypoplasia (HP:0003187)2.14201871
80Cortical dysplasia (HP:0002539)2.14093335
81Emotional lability (HP:0000712)2.13701955
82Hypoplasia of the brainstem (HP:0002365)2.10625929
83Aplasia/Hypoplasia of the brainstem (HP:0007362)2.10625929
84Impaired smooth pursuit (HP:0007772)2.09979407
85Abnormality of aromatic amino acid family metabolism (HP:0004338)2.09962959
86Chronic hepatic failure (HP:0100626)2.08766573
87Hypoplastic nipples (HP:0002557)2.06438423
88Genital tract atresia (HP:0001827)2.05600565
89Type 2 muscle fiber atrophy (HP:0003554)2.03784653
90Acute encephalopathy (HP:0006846)2.03381789
91Absence seizures (HP:0002121)2.03004487
92Febrile seizures (HP:0002373)2.02933230
93Tubulointerstitial abnormality (HP:0001969)2.01976207
94Chromsome breakage (HP:0040012)2.01761905
95Tubulointerstitial fibrosis (HP:0005576)2.01614480
96Hypothermia (HP:0002045)12.4170631
97Abnormality of the aortic arch (HP:0012303)1.99402600
98Morphological abnormality of the pyramidal tract (HP:0002062)1.98659116
99Type II lissencephaly (HP:0007260)1.98405155
100Dysautonomia (HP:0002459)1.96229715
101Oligodactyly (HP:0012165)1.93747981
102Neoplasm of the thyroid gland (HP:0100031)1.93068169
103Increased hepatocellular lipid droplets (HP:0006565)1.90863181
104Renal dysplasia (HP:0000110)1.89429452
105Poor coordination (HP:0002370)1.89067986
106Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.88567738
107Enlarged penis (HP:0000040)1.86666934
108Supranuclear gaze palsy (HP:0000605)1.86540282
109Lipid accumulation in hepatocytes (HP:0006561)1.85410792
110Rib fusion (HP:0000902)1.84746712
111Cutaneous finger syndactyly (HP:0010554)1.83095251
112Abnormality of the labia minora (HP:0012880)1.82225169
113Nephronophthisis (HP:0000090)1.80574012
114Limb hypertonia (HP:0002509)1.80287892
115Hyperparathyroidism (HP:0000843)1.79889024
116Gastrointestinal atresia (HP:0002589)1.79555913
117Septo-optic dysplasia (HP:0100842)1.79477606
118Oligodactyly (hands) (HP:0001180)1.79176608
119Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.78945023
120Asplenia (HP:0001746)1.78357040
121Cerebellar dysplasia (HP:0007033)1.78141750
122Delusions (HP:0000746)1.76342286
123Vertebral arch anomaly (HP:0008438)1.76110745
124Depression (HP:0000716)1.75787284
125Neonatal onset (HP:0003623)1.75785592
126Vaginal atresia (HP:0000148)1.75399143
127Occipital encephalocele (HP:0002085)1.74836082
128Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.74474286
129Ectopic kidney (HP:0000086)1.74417907
130Specific learning disability (HP:0001328)1.71894237
131Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.71704278
132Hyperventilation (HP:0002883)1.70530641
133Testicular neoplasm (HP:0010788)1.69178356
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.68701733
135Abnormality of the 2nd finger (HP:0004100)1.68593609
136Lissencephaly (HP:0001339)1.67971898
137Craniofacial dystonia (HP:0012179)1.66704790
138Drooling (HP:0002307)1.65781380
139Depressed nasal tip (HP:0000437)1.65725798
140Goiter (HP:0000853)1.64885017
141Increased corneal curvature (HP:0100692)1.64831614
142Keratoconus (HP:0000563)1.64831614
143Bony spicule pigmentary retinopathy (HP:0007737)1.64562091
144Retinal dysplasia (HP:0007973)1.64457737
145Dysmetria (HP:0001310)1.64182979
146Impaired vibratory sensation (HP:0002495)1.62798374
147Psychosis (HP:0000709)1.62614113
148Dialeptic seizures (HP:0011146)1.62281981
149Aplasia/Hypoplasia of the macula (HP:0008059)1.62028191
150Increased CSF lactate (HP:0002490)1.60303022
151Rhinitis (HP:0012384)1.57530172
152Stenosis of the external auditory canal (HP:0000402)1.56349470
153Ankle clonus (HP:0011448)1.55485925
154Shoulder girdle muscle weakness (HP:0003547)1.54490541
155Gait imbalance (HP:0002141)1.54261084
156Optic disc pallor (HP:0000543)1.53448655
157Bicornuate uterus (HP:0000813)1.52461634
158Torticollis (HP:0000473)1.51688832
159Focal dystonia (HP:0004373)1.50728263
160Pendular nystagmus (HP:0012043)1.50505820
161Wrist flexion contracture (HP:0001239)1.50141244
162Aplasia/Hypoplasia affecting the retina (HP:0008061)1.49760196
163Potter facies (HP:0002009)1.49751382
164Facial shape deformation (HP:0011334)1.49751382
165Hepatocellular necrosis (HP:0001404)1.49096884
166Ulnar claw (HP:0001178)1.48939444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK15.38294433
2GRK74.54029765
3NTRK33.63586368
4ZAK3.33510198
5TLK13.28061855
6MAP3K42.96873679
7MARK12.76680993
8GRK52.75610089
9MATK2.72178820
10TSSK62.64379708
11PNCK2.37146131
12CSNK1G32.32595100
13INSRR2.25579466
14BUB12.02953224
15MAP2K41.94732766
16CSNK1G21.91486172
17MAP3K101.88881459
18MINK11.87435758
19UHMK11.86401983
20NTRK21.81297525
21ADRBK11.76558424
22MAP3K121.70446124
23TTK1.60486498
24MAP2K11.48103130
25MAP2K71.47094131
26CSNK1G11.44497027
27ARAF1.43782629
28DYRK21.41586622
29LIMK11.41528384
30WNK31.39656423
31VRK11.34619771
32CDC71.30969431
33TGFBR11.28788787
34MAPK131.27729171
35CAMKK11.27186265
36PLK21.26810179
37PLK41.20549896
38MAP4K21.17819610
39CHEK21.17105990
40MAPKAPK51.16451323
41DAPK21.15496481
42BMPR1B1.13321138
43EPHB21.11400343
44ERBB21.10316908
45CASK1.10155650
46PINK11.08642960
47TESK11.03971836
48PRKCE1.02677609
49EPHA41.01957650
50MAP3K21.01830813
51PRKCG1.00181456
52PHKG20.98894664
53PHKG10.98894664
54TAF10.98162990
55MAP3K90.95637762
56CSNK1A1L0.95251445
57TRIM280.93213035
58DYRK30.91216051
59TYRO30.91123179
60CDK30.89354563
61ICK0.88132425
62CDK180.88016926
63SGK4940.87085927
64SGK2230.87085927
65CDK150.86900379
66CDK140.83576233
67CDK190.82034891
68ATR0.81035427
69AURKA0.80063179
70BRAF0.79866297
71PLK30.79521827
72ACVR1B0.78924967
73BRD40.78041135
74CDK11A0.77132873
75CDK50.75938586
76DAPK10.75283004
77CAMK2B0.75238836
78STK160.74898570
79PKN10.74804031
80CAMK40.74317311
81TNIK0.72604484
82PAK30.71445102
83PLK10.71168310
84SIK20.70654165
85LATS20.66804752
86CSNK1E0.66615202
87NEK10.65241345
88RPS6KA50.64601979
89PRKDC0.63765707
90MAP3K110.62305602
91MAP2K30.61969199
92FGR0.61862967
93ATM0.61466893
94MKNK20.60823361
95PRKCZ0.60491107
96CAMK2A0.60372485
97ILK0.60243447
98CAMK2G0.60197935
99SRPK10.60195436
100GRK60.59795402
101CDK80.58894415
102CSNK1D0.57895299
103ADRBK20.57689001
104KSR20.57049677
105SIK30.56870585
106CAMK10.56595821
107MAP2K60.54796639
108DYRK1A0.54468796
109PRKG10.53799332
110GRK10.51507311
111PASK0.51185495
112DYRK1B0.51113572
113MAPK40.49881475
114RPS6KA20.48382847
115NME10.48182374
116KSR10.47192190
117PDK30.47137259
118PDK40.47137259
119MARK20.47068276
120ALK0.46894586
121AKT30.46886541
122FGFR20.46827251
123PRKAA10.46261754
124MYLK0.46038290
125PRKCB0.43534276
126LMTK20.43251901
127WNK40.42682748
128CAMK2D0.42393959
129MAPK150.41675526
130CDK10.40971264
131STK110.40593776
132BCKDK0.40544526
133PIM20.40046673
134CDK20.39824137
135CAMK1D0.38852083
136AURKB0.38763662
137PRKACA0.37656521
138PDK20.37505331
139YES10.36898908
140ERBB30.36556675
141PAK60.36544343
142NLK0.36318241
143BCR0.36230019
144IGF1R0.36209363
145CAMK1G0.35294477
146MAPK80.34636314
147PDGFRA0.34323103
148CAMKK20.30965698
149RET0.30595319
150DAPK30.30369509
151HIPK20.29623803

Predicted pathways (KEGG)

RankGene SetZ-score
1Tyrosine metabolism_Homo sapiens_hsa003504.11846596
2Phenylalanine metabolism_Homo sapiens_hsa003603.55852428
3Cocaine addiction_Homo sapiens_hsa050303.10761699
4Oxidative phosphorylation_Homo sapiens_hsa001903.04616731
5Synaptic vesicle cycle_Homo sapiens_hsa047213.00686644
6Parkinsons disease_Homo sapiens_hsa050122.90582005
7Proteasome_Homo sapiens_hsa030502.71665797
8Amphetamine addiction_Homo sapiens_hsa050312.66463858
9Nitrogen metabolism_Homo sapiens_hsa009102.52456484
10Dopaminergic synapse_Homo sapiens_hsa047282.49017480
11* Cholinergic synapse_Homo sapiens_hsa047252.36044901
12Collecting duct acid secretion_Homo sapiens_hsa049662.25546825
13Serotonergic synapse_Homo sapiens_hsa047262.20267866
14Alzheimers disease_Homo sapiens_hsa050102.16687024
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.16331685
16Histidine metabolism_Homo sapiens_hsa003401.96229624
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92254272
18Huntingtons disease_Homo sapiens_hsa050161.86607540
19Vibrio cholerae infection_Homo sapiens_hsa051101.83260623
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.80663819
21Circadian entrainment_Homo sapiens_hsa047131.75612740
22Renin secretion_Homo sapiens_hsa049241.66175860
23Nicotine addiction_Homo sapiens_hsa050331.60926873
24Fanconi anemia pathway_Homo sapiens_hsa034601.60635244
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.57301978
26Ribosome_Homo sapiens_hsa030101.56241219
27Long-term depression_Homo sapiens_hsa047301.48166659
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.46941250
29Insulin secretion_Homo sapiens_hsa049111.41429869
30Olfactory transduction_Homo sapiens_hsa047401.40702541
31Glutamatergic synapse_Homo sapiens_hsa047241.40450946
32Cardiac muscle contraction_Homo sapiens_hsa042601.40279195
33Gap junction_Homo sapiens_hsa045401.39349660
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35242990
35RNA polymerase_Homo sapiens_hsa030201.26769049
36Long-term potentiation_Homo sapiens_hsa047201.23942340
37Taste transduction_Homo sapiens_hsa047421.21174797
38Salivary secretion_Homo sapiens_hsa049701.20637297
39GnRH signaling pathway_Homo sapiens_hsa049121.20195801
40Tryptophan metabolism_Homo sapiens_hsa003801.19965967
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19962484
42Alcoholism_Homo sapiens_hsa050341.19745482
43Cell cycle_Homo sapiens_hsa041101.16321659
44GABAergic synapse_Homo sapiens_hsa047271.14893776
45Morphine addiction_Homo sapiens_hsa050321.14242293
46* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14019226
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11893982
48Gastric acid secretion_Homo sapiens_hsa049711.10848440
49Systemic lupus erythematosus_Homo sapiens_hsa053221.10782642
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.08915614
51Protein export_Homo sapiens_hsa030601.05527257
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.03685562
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.01783623
54Bile secretion_Homo sapiens_hsa049760.98597676
55Estrogen signaling pathway_Homo sapiens_hsa049150.97268540
56Homologous recombination_Homo sapiens_hsa034400.95803882
57Calcium signaling pathway_Homo sapiens_hsa040200.94420072
58Melanogenesis_Homo sapiens_hsa049160.91771260
59Basal transcription factors_Homo sapiens_hsa030220.89351583
60Non-homologous end-joining_Homo sapiens_hsa034500.87563748
61Oxytocin signaling pathway_Homo sapiens_hsa049210.86981396
62Base excision repair_Homo sapiens_hsa034100.86898819
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86095119
64Mismatch repair_Homo sapiens_hsa034300.84101357
65Arginine and proline metabolism_Homo sapiens_hsa003300.83384888
66Axon guidance_Homo sapiens_hsa043600.79192876
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77418456
68Pancreatic secretion_Homo sapiens_hsa049720.76868246
69DNA replication_Homo sapiens_hsa030300.75030237
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.74613961
71RNA transport_Homo sapiens_hsa030130.74180348
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73214338
73RNA degradation_Homo sapiens_hsa030180.71544694
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70674036
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70082402
76Basal cell carcinoma_Homo sapiens_hsa052170.67776714
77Thyroid hormone synthesis_Homo sapiens_hsa049180.67341789
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67224610
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.67201095
80Glucagon signaling pathway_Homo sapiens_hsa049220.66838706
81Ovarian steroidogenesis_Homo sapiens_hsa049130.64949568
82Regulation of autophagy_Homo sapiens_hsa041400.64155731
83Phototransduction_Homo sapiens_hsa047440.60563398
84Phagosome_Homo sapiens_hsa041450.60562160
85Oocyte meiosis_Homo sapiens_hsa041140.59548585
86Butanoate metabolism_Homo sapiens_hsa006500.59484943
87Notch signaling pathway_Homo sapiens_hsa043300.58586627
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57884948
89Dilated cardiomyopathy_Homo sapiens_hsa054140.56520481
90Thyroid cancer_Homo sapiens_hsa052160.56016036
91Selenocompound metabolism_Homo sapiens_hsa004500.55415413
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.54151288
93African trypanosomiasis_Homo sapiens_hsa051430.52468626
94mRNA surveillance pathway_Homo sapiens_hsa030150.52070639
95Sulfur relay system_Homo sapiens_hsa041220.51952074
96Spliceosome_Homo sapiens_hsa030400.50567960
97cAMP signaling pathway_Homo sapiens_hsa040240.49732324
98Fructose and mannose metabolism_Homo sapiens_hsa000510.46756569
99Glycerolipid metabolism_Homo sapiens_hsa005610.45923208
100Dorso-ventral axis formation_Homo sapiens_hsa043200.45468634
101Prion diseases_Homo sapiens_hsa050200.45039619
102Fatty acid elongation_Homo sapiens_hsa000620.43844778
103Non-small cell lung cancer_Homo sapiens_hsa052230.42419343
104cGMP-PKG signaling pathway_Homo sapiens_hsa040220.41047425
105Glioma_Homo sapiens_hsa052140.40260535
106Pyrimidine metabolism_Homo sapiens_hsa002400.39699502
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39482187
108Steroid biosynthesis_Homo sapiens_hsa001000.37750233
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37365341
110Hippo signaling pathway_Homo sapiens_hsa043900.37245801
1112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.36457191
112Circadian rhythm_Homo sapiens_hsa047100.36378467
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33588217
114Wnt signaling pathway_Homo sapiens_hsa043100.33259734
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.31697583
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.31485152
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31082449
118Nucleotide excision repair_Homo sapiens_hsa034200.30938053
119Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.30738754
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.30062663
121Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30049684
122Pyruvate metabolism_Homo sapiens_hsa006200.29994198
123Purine metabolism_Homo sapiens_hsa002300.28853499
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.28551772
125Propanoate metabolism_Homo sapiens_hsa006400.27017255
126Rheumatoid arthritis_Homo sapiens_hsa053230.26721520
127Type II diabetes mellitus_Homo sapiens_hsa049300.25821801
128Insulin signaling pathway_Homo sapiens_hsa049100.25739091
129Colorectal cancer_Homo sapiens_hsa052100.25583480
130Hedgehog signaling pathway_Homo sapiens_hsa043400.23852791
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23473884
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.23236157
133Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17321394
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.16569414
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.16301356
136Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.16053561
137ErbB signaling pathway_Homo sapiens_hsa040120.13715503

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