CHRNA10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)8.13891243
2actin filament-based movement (GO:0030048)7.46494385
3striated muscle contraction (GO:0006941)7.24247515
4vitamin transmembrane transport (GO:0035461)7.00615208
5skeletal muscle fiber development (GO:0048741)6.94383795
6response to muscle activity (GO:0014850)6.64274713
7myotube cell development (GO:0014904)6.09024883
8lung-associated mesenchyme development (GO:0060484)5.91983827
9mitotic metaphase plate congression (GO:0007080)5.88798255
10glycogen catabolic process (GO:0005980)5.76698372
11response to inactivity (GO:0014854)5.72949397
12glucan catabolic process (GO:0009251)5.49135042
13muscle contraction (GO:0006936)5.45925998
14ventricular cardiac muscle cell development (GO:0055015)5.41647430
15neurotransmitter catabolic process (GO:0042135)5.33809497
16regulation of spindle organization (GO:0090224)5.24272738
17cellular polysaccharide catabolic process (GO:0044247)5.17486300
18rRNA modification (GO:0000154)5.14119425
19glycogen biosynthetic process (GO:0005978)5.00008159
20glucan biosynthetic process (GO:0009250)5.00008159
21muscle system process (GO:0003012)4.93004661
22purine nucleobase biosynthetic process (GO:0009113)4.90467133
23muscle fiber development (GO:0048747)4.90423360
24cardiac muscle contraction (GO:0060048)4.88326178
25skeletal muscle tissue regeneration (GO:0043403)4.74532692
26cardiac muscle cell development (GO:0055013)4.71835955
27regulation of actin filament-based movement (GO:1903115)4.66555403
28polysaccharide catabolic process (GO:0000272)4.65221530
29striated muscle adaptation (GO:0014888)4.55495001
30skeletal muscle tissue development (GO:0007519)4.53137980
31sarcomere organization (GO:0045214)4.52367577
32rRNA methylation (GO:0031167)4.51852599
33regulation of mitotic spindle organization (GO:0060236)4.51667359
34cardiac cell development (GO:0055006)4.50478713
35ribosome assembly (GO:0042255)4.43046889
36metaphase plate congression (GO:0051310)4.41980597
37termination of RNA polymerase III transcription (GO:0006386)4.38297510
38transcription elongation from RNA polymerase III promoter (GO:0006385)4.38297510
39myofibril assembly (GO:0030239)4.29324152
40muscle organ morphogenesis (GO:0048644)4.29262655
41transcription elongation from RNA polymerase I promoter (GO:0006362)4.26187542
42myoblast fusion (GO:0007520)4.26101465
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.25412417
44actin-myosin filament sliding (GO:0033275)4.24687784
45muscle filament sliding (GO:0030049)4.24687784
46cardiac muscle hypertrophy (GO:0003300)4.23315548
47positive regulation of myotube differentiation (GO:0010831)4.21812074
48NADH metabolic process (GO:0006734)4.21596343
49response to activity (GO:0014823)4.15126706
50muscle cell cellular homeostasis (GO:0046716)4.15082412
51ventricular cardiac muscle cell action potential (GO:0086005)4.12161439
52regulation of skeletal muscle contraction (GO:0014819)4.11454179
53positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.10996940
54biotin metabolic process (GO:0006768)4.09887973
55regulation of cell communication by electrical coupling (GO:0010649)4.06452087
56positive regulation of chromosome segregation (GO:0051984)4.06392433
57glycogen metabolic process (GO:0005977)4.06082296
582-oxoglutarate metabolic process (GO:0006103)4.05846184
59sarcoplasmic reticulum calcium ion transport (GO:0070296)4.04951421
60nucleobase biosynthetic process (GO:0046112)4.03979960
61striated muscle hypertrophy (GO:0014897)4.02493492
62cellular glucan metabolic process (GO:0006073)4.00197510
63glucan metabolic process (GO:0044042)4.00197510
64fructose metabolic process (GO:0006000)3.99855179
65ribosome biogenesis (GO:0042254)3.98911886
66negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.98760582
67syncytium formation by plasma membrane fusion (GO:0000768)3.97059015
68DNA replication checkpoint (GO:0000076)3.96272062
69termination of RNA polymerase I transcription (GO:0006363)3.96264018
70muscle adaptation (GO:0043500)3.91763732
71regulation of G0 to G1 transition (GO:0070316)3.86626093
72intestinal epithelial cell development (GO:0060576)3.86347737
73cardiac myofibril assembly (GO:0055003)3.80275139
74transcription from RNA polymerase I promoter (GO:0006360)3.75536317
75IMP metabolic process (GO:0046040)3.74978081
76muscle structure development (GO:0061061)3.72597861
77monoubiquitinated protein deubiquitination (GO:0035520)3.69601067
78muscle organ development (GO:0007517)3.66079363
79striated muscle cell development (GO:0055002)3.63455883
80skeletal muscle adaptation (GO:0043501)3.63058996
81muscle hypertrophy (GO:0014896)3.62412019
82regulation of exit from mitosis (GO:0007096)3.62075707
83muscle atrophy (GO:0014889)3.61898181
84folic acid transport (GO:0015884)3.60770251
85blastocyst development (GO:0001824)3.59639878
86negative regulation of muscle contraction (GO:0045932)3.58479042
87positive regulation of cardiac muscle cell proliferation (GO:0060045)3.58335485
88adult heart development (GO:0007512)3.57526653
89transcription initiation from RNA polymerase I promoter (GO:0006361)3.55349464
90neuronal action potential propagation (GO:0019227)3.55174173
91positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.54121404
92regulation of striated muscle contraction (GO:0006942)3.53488753
93regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.49859140
94folic acid metabolic process (GO:0046655)3.49242996
95serine family amino acid catabolic process (GO:0009071)3.48622044
96pyrimidine-containing compound transmembrane transport (GO:0072531)3.48035037
97gluconeogenesis (GO:0006094)3.45457674
98positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.45076970
99negative regulation of fibroblast apoptotic process (GO:2000270)3.44757012
100actin-mediated cell contraction (GO:0070252)3.43125061
101positive regulation of cardiac muscle tissue growth (GO:0055023)3.43066315
102positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.41538121
1037-methylguanosine mRNA capping (GO:0006370)3.40824296
104regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.40243254
105mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.39470363
106positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.39470363
107muscle tissue morphogenesis (GO:0060415)3.35884480
108negative regulation of potassium ion transmembrane transport (GO:1901380)3.34118144
109cardiac muscle hypertrophy in response to stress (GO:0014898)3.31532948
110muscle hypertrophy in response to stress (GO:0003299)3.31532948
111cardiac muscle adaptation (GO:0014887)3.31532948
112cellular carbohydrate catabolic process (GO:0044275)3.30765211
113regulation of skeletal muscle cell differentiation (GO:2001014)3.30038950
114protein localization to kinetochore (GO:0034501)3.27097612
115positive regulation of protein depolymerization (GO:1901881)3.25731167
116ubiquinone biosynthetic process (GO:0006744)3.25310371
117RNA capping (GO:0036260)3.24562873
1187-methylguanosine RNA capping (GO:0009452)3.24562873
119plasma membrane repair (GO:0001778)3.23712714
120germinal center formation (GO:0002467)3.21456831
121neuromuscular synaptic transmission (GO:0007274)3.21081419
122negative regulation of necroptotic process (GO:0060546)3.18230304
123regulation of calcium ion transmembrane transporter activity (GO:1901019)3.18123065
124regulation of calcium ion transmembrane transport (GO:1903169)3.18123065
125syncytium formation (GO:0006949)3.17520086
126establishment of chromosome localization (GO:0051303)3.15026170
127hexose biosynthetic process (GO:0019319)3.14188097
128protein localization to chromosome, centromeric region (GO:0071459)3.14142857
129heart contraction (GO:0060047)3.13974065
130heart process (GO:0003015)3.13974065
131otic vesicle formation (GO:0030916)3.13680537
132cardiac muscle tissue morphogenesis (GO:0055008)3.13050508
133muscle cell development (GO:0055001)3.11017227
134labyrinthine layer development (GO:0060711)3.10446686
135positive regulation of DNA-templated transcription, initiation (GO:2000144)3.09822782
136actomyosin structure organization (GO:0031032)3.09693290
137muscle cell fate commitment (GO:0042693)3.09003407
138carnitine shuttle (GO:0006853)3.08900329
139regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08563340
140regulation of sequestering of triglyceride (GO:0010889)3.06195705
141regulation of cardioblast differentiation (GO:0051890)3.05847664
142regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.05567529
143meiosis I (GO:0007127)3.04459254
144cardiac muscle cell action potential involved in contraction (GO:0086002)3.02394509
145skeletal muscle cell differentiation (GO:0035914)3.00573805
146negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.00172802
147regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.99758956
148purine nucleotide salvage (GO:0032261)2.98762069
149relaxation of muscle (GO:0090075)2.98148460
150striated muscle atrophy (GO:0014891)2.97703961
151cardiac muscle cell action potential (GO:0086001)2.97476220
152striated muscle tissue development (GO:0014706)2.97091853
153CDP-diacylglycerol metabolic process (GO:0046341)2.96649967
154spindle checkpoint (GO:0031577)2.93655606
155tricarboxylic acid cycle (GO:0006099)2.93371640
156glycine metabolic process (GO:0006544)2.93004502
157positive regulation of mitochondrial membrane permeability (GO:0035794)2.92341216
158synaptonemal complex assembly (GO:0007130)2.89923736
159DNA-templated transcription, elongation (GO:0006354)2.89332812
160skeletal muscle contraction (GO:0003009)2.88177901
161bundle of His cell to Purkinje myocyte communication (GO:0086069)2.80930013
162positive regulation of heart growth (GO:0060421)2.80809050
163GMP metabolic process (GO:0046037)2.80586081
164transcription elongation from RNA polymerase II promoter (GO:0006368)2.80434612
165fatty acid homeostasis (GO:0055089)2.79894193
166regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78812995
167regulation of chromosome segregation (GO:0051983)2.77222126
168synaptonemal complex organization (GO:0070193)2.76597236
169anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75412637
170proteasome assembly (GO:0043248)2.73830486
171response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.73734096
172attachment of spindle microtubules to kinetochore (GO:0008608)2.72717036
173protein K6-linked ubiquitination (GO:0085020)2.71756751
174creatine metabolic process (GO:0006600)2.68164383
175S-adenosylmethionine metabolic process (GO:0046500)2.68055693
176polyamine biosynthetic process (GO:0006596)2.67869190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.28967359
2EZH2_22144423_ChIP-Seq_EOC_Human6.48877439
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.40211107
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.66792592
5FOXM1_23109430_ChIP-Seq_U2OS_Human4.25963610
6ZNF263_19887448_ChIP-Seq_K562_Human3.84515765
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.65192055
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.40412297
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.05153608
10STAT6_21828071_ChIP-Seq_BEAS2B_Human3.04145733
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.02470966
12AR_21909140_ChIP-Seq_LNCAP_Human2.88096576
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.83314897
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.71571301
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.49483202
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.42690328
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.39051727
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36344771
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.32709052
20ESR1_20079471_ChIP-ChIP_T-47D_Human2.32224339
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18418169
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.16055802
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15797567
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.04056509
25PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.96453800
26ESR2_21235772_ChIP-Seq_MCF-7_Human1.92937426
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.91018475
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.90511495
29VDR_21846776_ChIP-Seq_THP-1_Human1.83407786
30LXR_22292898_ChIP-Seq_THP-1_Human1.83390008
31* CTCF_27219007_Chip-Seq_Bcells_Human1.77646097
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76606366
33KDM2B_26808549_Chip-Seq_DND41_Human1.74480793
34VDR_23849224_ChIP-Seq_CD4+_Human1.71074326
35CTCF_21964334_ChIP-Seq_BJAB-B_Human1.70804720
36TCF7_22412390_ChIP-Seq_EML_Mouse1.70104706
37MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67537099
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.64601515
39P68_20966046_ChIP-Seq_HELA_Human1.61306582
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.56755828
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.56395878
42EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.55569068
43CTCF_27219007_Chip-Seq_ERYTHROID_Human1.55303161
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.53689888
45TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53671769
46MAF_26560356_Chip-Seq_TH1_Human1.51743685
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51696417
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.50886803
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.49721067
50XRN2_22483619_ChIP-Seq_HELA_Human1.49045544
51SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.48398967
52MAF_26560356_Chip-Seq_TH2_Human1.48197028
53EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.47371819
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.46155075
55NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.45413192
56GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.45127964
57HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41341310
58NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.40106321
59SMC4_20622854_ChIP-Seq_HELA_Human1.39257116
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.38886117
61BCOR_27268052_Chip-Seq_Bcells_Human1.37745635
62SPI1_20517297_ChIP-Seq_HL60_Human1.37451472
63NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.37364344
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36960518
65LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36108811
66GATA1_19941827_ChIP-Seq_MEL_Mouse1.35960852
67CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.34317147
68BCL6_27268052_Chip-Seq_Bcells_Human1.33918816
69* SA1_27219007_Chip-Seq_ERYTHROID_Human1.33319043
70* SPI1_23127762_ChIP-Seq_K562_Human1.30520914
71CLOCK_20551151_ChIP-Seq_293T_Human1.28660382
72MYC_22102868_ChIP-Seq_BL_Human1.28452552
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28138770
74OCT4_20526341_ChIP-Seq_ESCs_Human1.27511173
75NANOG_18692474_ChIP-Seq_MEFs_Mouse1.27251416
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26945249
77KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25876195
78GABP_19822575_ChIP-Seq_HepG2_Human1.24471998
79CTCF_21964334_Chip-Seq_Bcells_Human1.24436298
80RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23273825
81E2F1_20622854_ChIP-Seq_HELA_Human1.22586830
82VDR_24763502_ChIP-Seq_THP-1_Human1.21962825
83LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.21758275
84MYC_27129775_Chip-Seq_CORNEA_Mouse1.21330033
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21186060
86RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21079222
87SRF_21415370_ChIP-Seq_HL-1_Mouse1.20430322
88FOXH1_21741376_ChIP-Seq_ESCs_Human1.19941906
89MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.19495149
90STAT1_20625510_ChIP-Seq_HELA_Human1.19364681
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19346402
92MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.18104796
93DROSHA_22980978_ChIP-Seq_HELA_Human1.17897643
94GATA6_21074721_ChIP-Seq_CACO-2_Human1.17801069
95YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17609981
96ELK1_22589737_ChIP-Seq_MCF10A_Human1.17191747
97POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16214825
98PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15451020
99FLI1_27457419_Chip-Seq_LIVER_Mouse1.14688983
100KDM5A_27292631_Chip-Seq_BREAST_Human1.14674549
101ZNF274_21170338_ChIP-Seq_K562_Hela1.14348722
102SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12558884
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11684921
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.10755345
105SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.09845277
106SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09490919
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.09428085
108TP63_22573176_ChIP-Seq_HFKS_Human1.08144076
109CIITA_25753668_ChIP-Seq_RAJI_Human1.08005419
110STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.07345767
111E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07188799
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06595115
113E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06206758
114BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06189586
115EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05841122
116TBX5_21415370_ChIP-Seq_HL-1_Mouse1.05372279
117NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04301742
118NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03804500
119SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.03510314
120GATA1_19941827_ChIP-Seq_MEL86_Mouse1.03422499
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03322530
122MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02568021
123NANOG_20526341_ChIP-Seq_ESCs_Human1.02403701
124OCT4_19829295_ChIP-Seq_ESCs_Human1.02234347
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.01817911
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00867769
127TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.00190176
128NANOG_21062744_ChIP-ChIP_HESCs_Human0.99561923
129TP63_17297297_ChIP-ChIP_HaCaT_Human0.99094816
130KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.98788499
131PHF8_20622854_ChIP-Seq_HELA_Human0.98334760
132RAC3_21632823_ChIP-Seq_H3396_Human0.98124850
133GATA4_21415370_ChIP-Seq_HL-1_Mouse0.97828585
134CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.97552958
135CEBPB_22108803_ChIP-Seq_LS180_Human0.97314288
136TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96041629
137STAT3_1855785_ChIP-Seq_MESCs_Mouse0.95982450
138PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95060691
139SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94752997
140POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.94481567
141PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93503571
142NFIB_24661679_ChIP-Seq_LUNG_Mouse0.93480740
143YY1_22570637_ChIP-Seq_MALME-3M_Human0.93076913
144TBX20_22080862_ChIP-Seq_HEART_Mouse0.92567430
145TBX20_22328084_ChIP-Seq_HEART_Mouse0.92567430
146NOTCH1_21737748_ChIP-Seq_TLL_Human0.92270811
147RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91802625
148DCP1A_22483619_ChIP-Seq_HELA_Human0.90469447
149SA1_27219007_Chip-Seq_Bcells_Human0.90112483
150RACK7_27058665_Chip-Seq_MCF-7_Human0.89859383
151PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89406827
152KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.89328997
153ATF3_27146783_Chip-Seq_COLON_Human0.89325731
154ESR1_21235772_ChIP-Seq_MCF-7_Human0.88649864
155* GATA3_21867929_ChIP-Seq_CD8_Mouse0.88350002
156SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88232971
157CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87705265
158TET1_21451524_ChIP-Seq_MESCs_Mouse0.87613805
159UTX_26944678_Chip-Seq_JUKART_Human0.87381316
160CREB1_26743006_Chip-Seq_LNCaP_Human0.87115247
161TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86893446
162PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.86720719
163CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86580502
164ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85880364
165CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85857303
166CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85415713
167KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84937995
168TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.84217926
169CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83767223
170POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.83080851
171POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82975833
172VDR_24787735_ChIP-Seq_THP-1_Human0.82740275
173UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.80392925
174KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80343431
175KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80343431
176KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80343431
177OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80175342
178DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78236359
179ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77327223
180CTCF_26484167_Chip-Seq_Bcells_Mouse0.76368152
181RUNX1_27514584_Chip-Seq_MCF-7_Human0.75426713
182CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75300166

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0003879_abnormal_hair_cell4.21206883
2MP0002254_reproductive_system_inflammat4.08089821
3MP0003646_muscle_fatigue3.91837023
4MP0005377_hearing/vestibular/ear_phenot3.75616509
5MP0003878_abnormal_ear_physiology3.75616509
6MP0001485_abnormal_pinna_reflex3.58198244
7MP0004084_abnormal_cardiac_muscle3.30173967
8MP0003693_abnormal_embryo_hatching3.18732197
9MP0004145_abnormal_muscle_electrophysio3.15238089
10MP0000751_myopathy2.93865122
11MP0002837_dystrophic_cardiac_calcinosis2.89149047
12MP0004036_abnormal_muscle_relaxation2.79652888
13MP0000750_abnormal_muscle_regeneration2.59820577
14MP0004215_abnormal_myocardial_fiber2.53389653
15MP0000749_muscle_degeneration2.52339716
16MP0001346_abnormal_lacrimal_gland2.47704775
17MP0000566_synostosis2.41583096
18MP0002106_abnormal_muscle_physiology2.33299159
19MP0005330_cardiomyopathy2.26593606
20MP0003941_abnormal_skin_development2.17309964
21MP0002269_muscular_atrophy2.17220838
22MP0003718_maternal_effect2.13837230
23MP0001348_abnormal_lacrimal_gland2.09030881
24MP0003221_abnormal_cardiomyocyte_apopto2.08891087
25MP0000747_muscle_weakness2.08134406
26MP0008260_abnormal_autophagy2.06647112
27MP0003111_abnormal_nucleus_morphology2.03365537
28MP0002876_abnormal_thyroid_physiology1.88857109
29MP0004087_abnormal_muscle_fiber1.86788709
30MP0004510_myositis1.82797283
31MP0003567_abnormal_fetal_cardiomyocyte1.82464913
32MP0003828_pulmonary_edema1.82445864
33MP0005369_muscle_phenotype1.78090832
34MP0005620_abnormal_muscle_contractility1.73266821
35MP0006138_congestive_heart_failure1.69774426
36MP0002108_abnormal_muscle_morphology1.67674903
37MP0005310_abnormal_salivary_gland1.58952714
38MP0003137_abnormal_impulse_conducting1.58308206
39MP0005266_abnormal_metabolism1.55711897
40MP0004484_altered_response_of1.54925981
41MP0000759_abnormal_skeletal_muscle1.52986836
42MP0004957_abnormal_blastocyst_morpholog1.47574042
43MP0001661_extended_life_span1.46639516
44MP0008057_abnormal_DNA_replication1.46584122
45MP0005385_cardiovascular_system_phenoty1.46497619
46MP0001544_abnormal_cardiovascular_syste1.46497619
47MP0002972_abnormal_cardiac_muscle1.45845376
48* MP0000026_abnormal_inner_ear1.43439627
49MP0005645_abnormal_hypothalamus_physiol1.41564788
50* MP0001963_abnormal_hearing_physiology1.37690841
51MP0000013_abnormal_adipose_tissue1.37247594
52MP0002971_abnormal_brown_adipose1.36212395
53MP0000383_abnormal_hair_follicle1.33020933
54MP0003077_abnormal_cell_cycle1.32666350
55MP0006036_abnormal_mitochondrial_physio1.27958457
56MP0003950_abnormal_plasma_membrane1.21034371
57MP0003938_abnormal_ear_development1.19972947
58MP0010630_abnormal_cardiac_muscle1.19607582
59MP0005375_adipose_tissue_phenotype1.18888063
60MP0004130_abnormal_muscle_cell1.17756185
61MP0005670_abnormal_white_adipose1.16439824
62MP0008058_abnormal_DNA_repair1.04468760
63MP0000733_abnormal_muscle_development1.01866891
64MP0010678_abnormal_skin_adnexa1.00204781
65MP0001730_embryonic_growth_arrest0.99517369
66MP0002653_abnormal_ependyma_morphology0.97171172
67MP0003656_abnormal_erythrocyte_physiolo0.94285254
68MP0002127_abnormal_cardiovascular_syste0.93101675
69MP0004147_increased_porphyrin_level0.89063150
70MP0001672_abnormal_embryogenesis/_devel0.89041117
71MP0005380_embryogenesis_phenotype0.89041117
72MP0000579_abnormal_nail_morphology0.86822740
73MP0004270_analgesia0.85777503
74MP0008775_abnormal_heart_ventricle0.85530163
75MP0008932_abnormal_embryonic_tissue0.85426103
76MP0003786_premature_aging0.84717769
77MP0001299_abnormal_eye_distance/0.82901416
78MP0003303_peritoneal_inflammation0.82511397
79MP0010030_abnormal_orbit_morphology0.80431395
80MP0004185_abnormal_adipocyte_glucose0.77022104
81MP0000428_abnormal_craniofacial_morphol0.76327444
82MP0001849_ear_inflammation0.75985335
83MP0000613_abnormal_salivary_gland0.74702206
84MP0004885_abnormal_endolymph0.73870290
85MP0004085_abnormal_heartbeat0.72941904
86MP0005395_other_phenotype0.72643193
87MP0005451_abnormal_body_composition0.70554936
88MP0002088_abnormal_embryonic_growth/wei0.69392333
89MP0005166_decreased_susceptibility_to0.69142890
90MP0008007_abnormal_cellular_replicative0.68893386
91MP0003984_embryonic_growth_retardation0.68436698
92MP0001986_abnormal_taste_sensitivity0.66640670
93MP0009840_abnormal_foam_cell0.66080851
94MP0000003_abnormal_adipose_tissue0.65857115
95MP0010094_abnormal_chromosome_stability0.64667340
96MP0004043_abnormal_pH_regulation0.63858030
97MP0008789_abnormal_olfactory_epithelium0.63136124
98MP0008877_abnormal_DNA_methylation0.63013207
99MP0005083_abnormal_biliary_tract0.62970839
100MP0005167_abnormal_blood-brain_barrier0.62900353
101MP0005647_abnormal_sex_gland0.62718346
102MP0000350_abnormal_cell_proliferation0.61320122
103MP0002332_abnormal_exercise_endurance0.60787957
104MP0004233_abnormal_muscle_weight0.57741567
105MP0001697_abnormal_embryo_size0.57354960
106MP0003045_fibrosis0.55577955
107MP0002210_abnormal_sex_determination0.55321493
108MP0002080_prenatal_lethality0.54769256
109MP0005535_abnormal_body_temperature0.54447874
110MP0002877_abnormal_melanocyte_morpholog0.53881926
111MP0004858_abnormal_nervous_system0.53830859
112MP0003123_paternal_imprinting0.53512130
113MP0002234_abnormal_pharynx_morphology0.53458057
114MP0009672_abnormal_birth_weight0.52902553
115MP0000372_irregular_coat_pigmentation0.52740046
116MP0002085_abnormal_embryonic_tissue0.52068518
117MP0009278_abnormal_bone_marrow0.50291543
118MP0006035_abnormal_mitochondrial_morpho0.49570978
119MP0005666_abnormal_adipose_tissue0.49115506
120MP0003755_abnormal_palate_morphology0.48769801
121MP0005187_abnormal_penis_morphology0.47801033
122MP0003806_abnormal_nucleotide_metabolis0.46982763
123MP0010307_abnormal_tumor_latency0.46940733
124MP0002163_abnormal_gland_morphology0.46359754
125MP0000266_abnormal_heart_morphology0.46235033
126MP0001873_stomach_inflammation0.45720432
127MP0005376_homeostasis/metabolism_phenot0.45668215
128MP0002078_abnormal_glucose_homeostasis0.43888628
129MP0005410_abnormal_fertilization0.40667656
130MP0004381_abnormal_hair_follicle0.39129456
131MP0005319_abnormal_enzyme/_coenzyme0.38661390
132MP0005584_abnormal_enzyme/coenzyme_acti0.38361251
133MP0005423_abnormal_somatic_nervous0.38157020
134MP0000343_altered_response_to0.36772606
135MP0008569_lethality_at_weaning0.32514864
136MP0003948_abnormal_gas_homeostasis0.31318373
137MP0009764_decreased_sensitivity_to0.29988268
138MP0005334_abnormal_fat_pad0.29474645
139MP0002277_abnormal_respiratory_mucosa0.27529382
140MP0002128_abnormal_blood_circulation0.27457094
141MP0005452_abnormal_adipose_tissue0.26806463
142MP0004142_abnormal_muscle_tone0.23304143
143MP0008874_decreased_physiological_sensi0.22347914
144MP0003705_abnormal_hypodermis_morpholog0.21823936
145MP0005058_abnormal_lysosome_morphology0.21364994
146MP0002132_abnormal_respiratory_system0.21101774
147MP0005248_abnormal_Harderian_gland0.19723911
148MP0003075_altered_response_to0.18869033
149MP0009115_abnormal_fat_cell0.18799983
150MP0002138_abnormal_hepatobiliary_system0.17998459
151MP0003724_increased_susceptibility_to0.17799139
152MP0005387_immune_system_phenotype0.17718244
153MP0001790_abnormal_immune_system0.17718244
154MP0002114_abnormal_axial_skeleton0.17240248

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber splitting (HP:0003555)6.22168822
2Hyperglycinemia (HP:0002154)5.12969321
3Round ear (HP:0100830)4.75533404
4Centrally nucleated skeletal muscle fibers (HP:0003687)4.73911315
5Ulnar deviation of the wrist (HP:0003049)4.72795745
6Bundle branch block (HP:0011710)4.70226350
7Muscle hypertrophy of the lower extremities (HP:0008968)4.67915471
8Abnormality of skeletal muscle fiber size (HP:0012084)4.28800478
9Sudden death (HP:0001699)4.25145626
10Atrioventricular block (HP:0001678)4.21616520
11Calf muscle hypertrophy (HP:0008981)4.21468894
12Areflexia of lower limbs (HP:0002522)4.17415633
13Hyperglycinuria (HP:0003108)4.16471103
14Exercise-induced muscle cramps (HP:0003710)4.07544442
15Ventricular tachycardia (HP:0004756)4.05244968
16Asymmetric septal hypertrophy (HP:0001670)3.99062883
17Exercise-induced myalgia (HP:0003738)3.95958215
18Ventricular fibrillation (HP:0001663)3.95864997
19Muscle fiber inclusion bodies (HP:0100299)3.93048636
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.86069354
21Frequent falls (HP:0002359)3.71367502
22Muscle stiffness (HP:0003552)3.67573427
23Heart block (HP:0012722)3.64645215
24Distal lower limb muscle weakness (HP:0009053)3.55936127
25Nemaline bodies (HP:0003798)3.50956617
26Progressive muscle weakness (HP:0003323)3.50126741
27Absent phalangeal crease (HP:0006109)3.49123957
28Difficulty climbing stairs (HP:0003551)3.46935558
29Hyperglycemia (HP:0003074)3.43798077
30Abnormality of glycine metabolism (HP:0010895)3.41218009
31Abnormality of serine family amino acid metabolism (HP:0010894)3.41218009
32Abnormal atrioventricular conduction (HP:0005150)3.37942512
33Gout (HP:0001997)3.36670057
34Increased variability in muscle fiber diameter (HP:0003557)3.35710328
35Malignant hyperthermia (HP:0002047)3.24762246
36Difficulty running (HP:0009046)3.14636341
37Ventricular arrhythmia (HP:0004308)3.08308761
38Right ventricular cardiomyopathy (HP:0011663)3.06461276
39Hyporeflexia of lower limbs (HP:0002600)3.05184809
40Generalized muscle weakness (HP:0003324)3.04036713
41Syncope (HP:0001279)3.01395603
42Impulsivity (HP:0100710)3.01335702
43EMG: neuropathic changes (HP:0003445)2.99761843
44Increased connective tissue (HP:0009025)2.98688507
45Abnormality of the calf musculature (HP:0001430)2.96613262
46Type 2 muscle fiber atrophy (HP:0003554)2.92565737
47Congenital, generalized hypertrichosis (HP:0004540)2.92422748
48Double outlet right ventricle (HP:0001719)2.84407386
49Congenital malformation of the right heart (HP:0011723)2.84407386
50Abnormal finger flexion creases (HP:0006143)2.80616609
51Hypoplastic ischia (HP:0003175)2.80605776
52Distal lower limb amyotrophy (HP:0008944)2.79113055
53Rimmed vacuoles (HP:0003805)2.77634185
54Weak cry (HP:0001612)2.73295739
55Muscle fibrillation (HP:0010546)2.72898704
56Irregular epiphyses (HP:0010582)2.70169515
57Mildly elevated creatine phosphokinase (HP:0008180)2.69763749
58Hyperkalemia (HP:0002153)2.69210763
59Breast hypoplasia (HP:0003187)2.67612939
60Abnormal auditory evoked potentials (HP:0006958)2.67304694
61Muscle fiber atrophy (HP:0100295)2.66698997
62Myopathic facies (HP:0002058)2.65907862
63Abnormality of the left ventricular outflow tract (HP:0011103)2.65580058
64Subaortic stenosis (HP:0001682)2.65580058
65Bulbar palsy (HP:0001283)2.63203932
66Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.62582260
67EMG: myopathic abnormalities (HP:0003458)2.62341905
68Slender build (HP:0001533)2.62031671
69Cerebral hypomyelination (HP:0006808)2.59289538
70Birth length less than 3rd percentile (HP:0003561)2.56804143
71Abnormality of the ischium (HP:0003174)2.52273123
72Myotonia (HP:0002486)2.51283013
73Atrial fibrillation (HP:0005110)2.48140101
74Abnormality of the neuromuscular junction (HP:0003398)2.47616203
75Fatigable weakness (HP:0003473)2.47616203
76Hyperuricemia (HP:0002149)2.45277010
77Increased purine levels (HP:0004368)2.45277010
78Distal arthrogryposis (HP:0005684)2.42418503
79Neck muscle weakness (HP:0000467)2.42327100
80Multiple enchondromatosis (HP:0005701)2.42039789
81Reduced subcutaneous adipose tissue (HP:0003758)2.40935307
82Calcaneovalgus deformity (HP:0001848)2.39539206
83Carpal bone hypoplasia (HP:0001498)2.39298926
84Deformed tarsal bones (HP:0008119)2.38654340
85Type 1 muscle fiber predominance (HP:0003803)2.36448285
86Myoglobinuria (HP:0002913)2.32732624
87Gowers sign (HP:0003391)2.32527392
88Rhabdomyolysis (HP:0003201)2.31714351
89Insulin-resistant diabetes mellitus (HP:0000831)2.31537591
90Limb-girdle muscle atrophy (HP:0003797)2.28798265
91Entropion (HP:0000621)2.27916799
92Shoulder girdle muscle weakness (HP:0003547)2.27547300
93Primary atrial arrhythmia (HP:0001692)2.27507243
94Abnormality of the calcaneus (HP:0008364)2.26951037
95Lipoatrophy (HP:0100578)2.24317861
96Unilateral renal agenesis (HP:0000122)2.23793753
97Ragged-red muscle fibers (HP:0003200)2.23095714
98Scapular winging (HP:0003691)2.21627248
99Pelvic girdle muscle weakness (HP:0003749)2.20160543
100Tongue fasciculations (HP:0001308)2.19621308
101Waddling gait (HP:0002515)2.19291175
102Supraventricular tachycardia (HP:0004755)2.19187683
103Lip pit (HP:0100267)2.17423152
104Pustule (HP:0200039)2.15581520
105Supraventricular arrhythmia (HP:0005115)2.13122814
106Fetal akinesia sequence (HP:0001989)2.12353530
107Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10462076
108Abnormality of serum amino acid levels (HP:0003112)2.10113848
109Mutism (HP:0002300)2.07837770
110Proximal amyotrophy (HP:0007126)2.07552606
111Rough bone trabeculation (HP:0100670)2.06810695
112Abnormality of the umbilical cord (HP:0010881)2.02667177
113Abnormality of the hip-girdle musculature (HP:0001445)2.02547492
114Abnormality of the musculature of the pelvis (HP:0001469)2.02547492
115Premature rupture of membranes (HP:0001788)2.01511968
116Spinal rigidity (HP:0003306)2.01318734
117Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01031684
118Absent epiphyses (HP:0010577)2.01031684
119Alopecia of scalp (HP:0002293)2.00972654
120Aplasia/Hypoplasia of the patella (HP:0006498)1.99336828
121Hip contracture (HP:0003273)1.97170655
122Humeroradial synostosis (HP:0003041)1.97147574
123Synostosis involving the elbow (HP:0003938)1.97147574
124Testicular atrophy (HP:0000029)1.96735718
125Muscular dystrophy (HP:0003560)1.95164063
126Lower limb amyotrophy (HP:0007210)1.95121342
127Patellar aplasia (HP:0006443)1.94780490
128Paralysis (HP:0003470)1.92376106
129Facial diplegia (HP:0001349)1.92354662
130Death in infancy (HP:0001522)1.92235652
131Type I diabetes mellitus (HP:0100651)1.91607446
132Dilated cardiomyopathy (HP:0001644)1.91353493
133Keratoconjunctivitis (HP:0001096)1.90763070
134Abnormality of the foot musculature (HP:0001436)1.85786484
135Abnormality of the shoulder girdle musculature (HP:0001435)1.75233318
136Metatarsus adductus (HP:0001840)1.69808864
137Foot dorsiflexor weakness (HP:0009027)1.69356125
138Respiratory insufficiency due to muscle weakness (HP:0002747)1.68602501
139Exercise intolerance (HP:0003546)1.66509176
140Nonprogressive disorder (HP:0003680)1.60669605
141Long clavicles (HP:0000890)1.58355533
142Popliteal pterygium (HP:0009756)1.55666708
143Limb-girdle muscle weakness (HP:0003325)1.55144090
144Ulnar deviation of finger (HP:0009465)1.42873352
145Easy fatigability (HP:0003388)1.37272033
146Fatigue (HP:0012378)1.28959808
147Amniotic constriction ring (HP:0009775)1.21387084
148Abnormality of placental membranes (HP:0011409)1.21387084
149Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.20981806
150Increased intramyocellular lipid droplets (HP:0012240)1.20923330
151Truncal obesity (HP:0001956)1.18758788
152Progressive external ophthalmoplegia (HP:0000590)1.17615762
153Limited hip movement (HP:0008800)1.17548390
154Short palpebral fissure (HP:0012745)1.16195017

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.21473047
2OBSCN3.46119847
3NME13.35152388
4EPHA33.11787291
5PIK3CG3.04035166
6WEE12.97919785
7TTN2.78078211
8PINK12.74907901
9PHKG22.69968998
10PHKG12.69968998
11MAP2K32.69617978
12ZAK2.64810440
13NEK12.48974157
14DYRK32.39871619
15DDR22.39392077
16AKT32.35527606
17LATS12.07281334
18NEK22.06412598
19MAPK122.04471549
20EIF2AK11.93889871
21LMTK21.84669928
22LATS21.82786832
23EPHA21.81333284
24IRAK31.70919717
25MKNK21.67915560
26BRSK21.61254375
27TTK1.60442818
28STK38L1.58429988
29PLK31.52041248
30PDK31.52030974
31PDK41.52030974
32DYRK1B1.51265336
33STK241.50738521
34PLK11.50726814
35SRPK11.42067236
36PLK41.40155566
37MKNK11.37859663
38NME21.29181701
39STK31.19360089
40MAP2K41.19269193
41DMPK1.14545046
42BRSK11.14116109
43MAP2K61.05077629
44ARAF1.04395818
45PRKAA11.03650914
46EIF2AK31.01880801
47CDK30.99140223
48WNK10.98235413
49PAK30.97357317
50KSR20.97315489
51CCNB10.96577006
52NUAK10.96376849
53AURKB0.93057220
54GRK70.92724900
55PDK20.90224071
56MAP3K130.90068221
57TRPM70.90023342
58TBK10.88666629
59BCKDK0.87234771
60ICK0.85761843
61MAP3K30.84465548
62KSR10.80451079
63EIF2AK20.80183078
64MARK30.78291845
65MAPKAPK30.77007860
66MAP3K10.76725958
67MOS0.75446219
68CAMK40.74928287
69MAP3K140.74149047
70PRKCI0.73236322
71EEF2K0.73063404
72ACVR1B0.72651456
73SIK10.71379998
74BRAF0.69644648
75CHEK20.69299924
76TSSK60.67994044
77ALK0.67491874
78MELK0.66781904
79TAOK20.65253400
80PAK60.62460738
81MAP3K110.61550584
82EPHB20.59465712
83MAPK70.59277437
84PRKAA20.58897836
85MAPK110.58447632
86FGFR40.57449575
87AURKA0.56662499
88CAMK2G0.54689640
89MARK20.54391002
90MUSK0.54167655
91MARK10.53702080
92MAP2K10.52640897
93RPS6KA40.51603890
94TAOK10.51014978
95CSNK1E0.50659927
96CDK190.47467892
97PIK3CA0.47407089
98MAPK130.46556460
99TRIB30.46299542
100CHEK10.44171594
101CDK80.43527938
102STK160.43217929
103SGK30.43087088
104CAMK10.43001273
105PRKG10.42874131
106PDGFRA0.42664270
107MAPK40.42450898
108TIE10.42412604
109EPHB10.41871033
110INSRR0.41865430
111PRPF4B0.41792984
112TNK20.40635492
113PKN10.40376831
114DYRK20.40277845
115BLK0.38669592
116ERBB30.37715633
117PDK10.34565483
118STK380.34033882
119ZAP700.32406492
120PRKD20.31383163
121RAF10.31277509
122CAMK2D0.30951120
123MAP3K80.30432270
124RPS6KC10.30121253
125RPS6KL10.30121253
126PRKACB0.29332386
127STK110.29244024
128CSK0.28737844
129AKT20.28581215
130ROCK10.28478131
131SGK10.28123140
132MAP3K70.26868433
133CDK70.26627006
134RPS6KA10.26623451
135MTOR0.26357985
136NEK60.26112052
137CAMK2A0.24389480
138RPS6KA60.23765145
139PDPK10.22682943
140RPS6KA50.22648490
141PRKACA0.22300370
142RIPK10.22080016
143MAPK100.22038946
144STK390.21973576
145MAP2K20.21920570
146FGFR30.21899161
147CDK20.21744567
148CSNK1A1L0.21729014
149CDK10.20322521
150PRKCG0.20031805
151SGK20.19923836
152MAP3K50.19848647
153JAK20.19836003
154RPS6KA30.19703256
155GRK50.19644444
156IKBKE0.19608560
157CSNK1G30.19551714
158LIMK10.19532586
159SIK20.18864281
160CDC42BPA0.18649247
161NEK90.18610101
162CHUK0.15639039
163RPS6KB10.13614736
164CDK90.13076091
165TYK20.12335895

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007508.03498622
2RNA polymerase_Homo sapiens_hsa030204.89779530
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.71959664
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69056859
5Proteasome_Homo sapiens_hsa030502.46657713
6RNA transport_Homo sapiens_hsa030132.41944572
7Vitamin digestion and absorption_Homo sapiens_hsa049772.14055873
8Regulation of autophagy_Homo sapiens_hsa041402.07748668
9Cell cycle_Homo sapiens_hsa041102.07109560
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.05394467
11Basal transcription factors_Homo sapiens_hsa030221.98438032
12Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.96914971
13Cardiac muscle contraction_Homo sapiens_hsa042601.90166602
14Dilated cardiomyopathy_Homo sapiens_hsa054141.84997155
15p53 signaling pathway_Homo sapiens_hsa041151.83893768
16Glycerophospholipid metabolism_Homo sapiens_hsa005641.72495139
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.70127109
18Pyrimidine metabolism_Homo sapiens_hsa002401.60723643
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.46213178
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.43379076
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.42420988
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41315456
23Purine metabolism_Homo sapiens_hsa002301.38673435
24Oocyte meiosis_Homo sapiens_hsa041141.38625501
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31740437
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.31070942
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.27806220
28cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20849953
29Circadian rhythm_Homo sapiens_hsa047101.19170078
30Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.15400994
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.15106922
32Spliceosome_Homo sapiens_hsa030401.14694195
33Nitrogen metabolism_Homo sapiens_hsa009101.12802358
34Pentose phosphate pathway_Homo sapiens_hsa000301.08697569
35GnRH signaling pathway_Homo sapiens_hsa049121.05511298
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99545856
37Carbon metabolism_Homo sapiens_hsa012000.97888445
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96365782
39Folate biosynthesis_Homo sapiens_hsa007900.96119669
40Phenylalanine metabolism_Homo sapiens_hsa003600.95790374
41Dorso-ventral axis formation_Homo sapiens_hsa043200.93249580
42Epstein-Barr virus infection_Homo sapiens_hsa051690.91645358
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.91608799
44Propanoate metabolism_Homo sapiens_hsa006400.90571044
45Long-term potentiation_Homo sapiens_hsa047200.90023789
46Galactose metabolism_Homo sapiens_hsa000520.89347712
47Arginine and proline metabolism_Homo sapiens_hsa003300.88265170
48Linoleic acid metabolism_Homo sapiens_hsa005910.87084686
49beta-Alanine metabolism_Homo sapiens_hsa004100.85758419
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.85349449
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.85206173
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.84517779
53FoxO signaling pathway_Homo sapiens_hsa040680.84445624
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83097587
55Biosynthesis of amino acids_Homo sapiens_hsa012300.81915359
56Gastric acid secretion_Homo sapiens_hsa049710.81114246
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.80983588
58Hippo signaling pathway_Homo sapiens_hsa043900.80087561
59Huntingtons disease_Homo sapiens_hsa050160.80029586
60Osteoclast differentiation_Homo sapiens_hsa043800.80019444
61VEGF signaling pathway_Homo sapiens_hsa043700.79111546
62MAPK signaling pathway_Homo sapiens_hsa040100.77824395
63Sulfur relay system_Homo sapiens_hsa041220.76626285
64Nucleotide excision repair_Homo sapiens_hsa034200.74869377
65Fatty acid degradation_Homo sapiens_hsa000710.72386434
66Pyruvate metabolism_Homo sapiens_hsa006200.72168685
67Tight junction_Homo sapiens_hsa045300.71157014
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.69829252
69Tuberculosis_Homo sapiens_hsa051520.67538874
70mTOR signaling pathway_Homo sapiens_hsa041500.67003797
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65678433
72mRNA surveillance pathway_Homo sapiens_hsa030150.64621203
73Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64547462
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.63476081
75Insulin signaling pathway_Homo sapiens_hsa049100.63337472
76Legionellosis_Homo sapiens_hsa051340.63224116
77Butanoate metabolism_Homo sapiens_hsa006500.62047510
78B cell receptor signaling pathway_Homo sapiens_hsa046620.61633706
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59410102
80Homologous recombination_Homo sapiens_hsa034400.56813364
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56016688
82Acute myeloid leukemia_Homo sapiens_hsa052210.54783831
83Insulin resistance_Homo sapiens_hsa049310.54654419
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54046536
85Non-small cell lung cancer_Homo sapiens_hsa052230.53792092
86Parkinsons disease_Homo sapiens_hsa050120.53758597
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53355609
88Melanoma_Homo sapiens_hsa052180.53326892
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.53276382
90Thyroid cancer_Homo sapiens_hsa052160.51089439
91Basal cell carcinoma_Homo sapiens_hsa052170.50594201
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.50259807
93Renal cell carcinoma_Homo sapiens_hsa052110.46709739
94Jak-STAT signaling pathway_Homo sapiens_hsa046300.45874210
95Fatty acid metabolism_Homo sapiens_hsa012120.45709857
96Glioma_Homo sapiens_hsa052140.45019107
97Hedgehog signaling pathway_Homo sapiens_hsa043400.44280695
98Bladder cancer_Homo sapiens_hsa052190.43644110
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42776247
100Arachidonic acid metabolism_Homo sapiens_hsa005900.42278158
101AMPK signaling pathway_Homo sapiens_hsa041520.41285286
102Small cell lung cancer_Homo sapiens_hsa052220.40999182
103PPAR signaling pathway_Homo sapiens_hsa033200.40943275
104Oxidative phosphorylation_Homo sapiens_hsa001900.39556216
105Intestinal immune network for IgA production_Homo sapiens_hsa046720.39452712
106Viral myocarditis_Homo sapiens_hsa054160.37492100
107Metabolic pathways_Homo sapiens_hsa011000.37142373
108Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36699950
109Calcium signaling pathway_Homo sapiens_hsa040200.36245217
110T cell receptor signaling pathway_Homo sapiens_hsa046600.36003860
111Glucagon signaling pathway_Homo sapiens_hsa049220.35488640
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.35377174
113Type II diabetes mellitus_Homo sapiens_hsa049300.34975908
114TNF signaling pathway_Homo sapiens_hsa046680.34330978
115Ether lipid metabolism_Homo sapiens_hsa005650.33039867
116Ribosome_Homo sapiens_hsa030100.31837124
117Fructose and mannose metabolism_Homo sapiens_hsa000510.31648494
118Long-term depression_Homo sapiens_hsa047300.31294053
119Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30898593
120Platelet activation_Homo sapiens_hsa046110.29749663
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.29588174
122Drug metabolism - other enzymes_Homo sapiens_hsa009830.28608712
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.28134533
124HIF-1 signaling pathway_Homo sapiens_hsa040660.27709650
125Malaria_Homo sapiens_hsa051440.26922145
126Prolactin signaling pathway_Homo sapiens_hsa049170.26773516
127Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26669371
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.25953989
129Influenza A_Homo sapiens_hsa051640.25825161
130MicroRNAs in cancer_Homo sapiens_hsa052060.25192656
131Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25088818
132Fatty acid biosynthesis_Homo sapiens_hsa000610.24927037
133Central carbon metabolism in cancer_Homo sapiens_hsa052300.24760438
134Starch and sucrose metabolism_Homo sapiens_hsa005000.24447339
135Notch signaling pathway_Homo sapiens_hsa043300.24411191
136Alzheimers disease_Homo sapiens_hsa050100.24193835
137Renin secretion_Homo sapiens_hsa049240.23973591
138Fanconi anemia pathway_Homo sapiens_hsa034600.23762572
139RNA degradation_Homo sapiens_hsa030180.22992598
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22869884
141Leishmaniasis_Homo sapiens_hsa051400.22656795
142Inositol phosphate metabolism_Homo sapiens_hsa005620.22023637
143Arginine biosynthesis_Homo sapiens_hsa002200.21587308
144Antigen processing and presentation_Homo sapiens_hsa046120.20898232
145HTLV-I infection_Homo sapiens_hsa051660.20727240
146Oxytocin signaling pathway_Homo sapiens_hsa049210.19686608
147Fatty acid elongation_Homo sapiens_hsa000620.19088619
148Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18700229
149Histidine metabolism_Homo sapiens_hsa003400.14350457

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