CHRM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.25537432
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)6.16227886
3regulation of short-term neuronal synaptic plasticity (GO:0048172)6.12726482
4locomotory exploration behavior (GO:0035641)5.97785786
5regulation of synapse structural plasticity (GO:0051823)5.72178392
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28340468
7prepulse inhibition (GO:0060134)5.27797766
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22182228
9regulation of long-term neuronal synaptic plasticity (GO:0048169)5.18379431
10vocalization behavior (GO:0071625)5.17432162
11regulation of glutamate receptor signaling pathway (GO:1900449)5.05111091
12regulation of neuronal synaptic plasticity (GO:0048168)4.97309068
13synaptic transmission, dopaminergic (GO:0001963)4.92606429
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.89934941
15synaptic vesicle exocytosis (GO:0016079)4.73603953
16membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.69039477
17neurotransmitter-gated ion channel clustering (GO:0072578)4.62891212
18striatum development (GO:0021756)4.61896549
19regulation of synaptic vesicle exocytosis (GO:2000300)4.51809896
20glutamate secretion (GO:0014047)4.46632569
21auditory behavior (GO:0031223)4.45360045
22adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.44040223
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.43980003
24regulation of ARF protein signal transduction (GO:0032012)4.43108351
25positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.40347348
26regulation of dendritic spine morphogenesis (GO:0061001)4.35970776
27adenosine receptor signaling pathway (GO:0001973)4.33576566
28dendritic spine morphogenesis (GO:0060997)4.32009884
29exploration behavior (GO:0035640)4.29132657
30protein localization to synapse (GO:0035418)4.28650512
31cytoskeletal anchoring at plasma membrane (GO:0007016)4.26615579
32cerebellar granule cell differentiation (GO:0021707)4.26236464
33neuromuscular process controlling balance (GO:0050885)4.22503032
34neurotransmitter secretion (GO:0007269)4.18805998
35neuron-neuron synaptic transmission (GO:0007270)4.15438610
36positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.15317276
37dopamine receptor signaling pathway (GO:0007212)4.14678406
38long-term memory (GO:0007616)4.10521518
39regulation of excitatory postsynaptic membrane potential (GO:0060079)4.09991902
40positive regulation of synaptic transmission, GABAergic (GO:0032230)4.09150197
41negative regulation of synaptic transmission, glutamatergic (GO:0051967)4.08493678
42synaptic transmission, glutamatergic (GO:0035249)4.07596975
43positive regulation of neurotransmitter transport (GO:0051590)4.07224209
44layer formation in cerebral cortex (GO:0021819)4.06189424
45positive regulation of membrane potential (GO:0045838)4.04224221
46response to amphetamine (GO:0001975)4.03741899
47neuronal action potential propagation (GO:0019227)4.02926950
48regulation of synaptic vesicle transport (GO:1902803)4.00652773
49response to auditory stimulus (GO:0010996)3.94259571
50negative regulation of dendrite morphogenesis (GO:0050774)3.91877759
51regulation of synaptic plasticity (GO:0048167)3.88400819
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.88001796
53behavioral response to cocaine (GO:0048148)3.86642914
54L-amino acid import (GO:0043092)3.83635785
55glutamate receptor signaling pathway (GO:0007215)3.79089990
56regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.77905599
57regulation of postsynaptic membrane potential (GO:0060078)3.77818359
58positive regulation of neurotransmitter secretion (GO:0001956)3.76248116
59negative regulation of cytosolic calcium ion concentration (GO:0051481)3.76240757
60activation of protein kinase A activity (GO:0034199)3.73275974
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.68239197
62transmission of nerve impulse (GO:0019226)3.66986099
63regulation of female receptivity (GO:0045924)3.66733785
64regulation of glutamate secretion (GO:0014048)3.63734574
65amino acid import (GO:0043090)3.63236947
66cAMP catabolic process (GO:0006198)3.61392585
67regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.59030064
68regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.59030064
69regulation of NFAT protein import into nucleus (GO:0051532)3.57083828
70long-term synaptic potentiation (GO:0060291)3.55839898
71behavioral fear response (GO:0001662)3.55242439
72behavioral defense response (GO:0002209)3.55242439
73gamma-aminobutyric acid transport (GO:0015812)3.53038656
74visual learning (GO:0008542)3.52220279
75synaptic vesicle endocytosis (GO:0048488)3.52091046
76neuronal ion channel clustering (GO:0045161)3.50832256
77substrate-independent telencephalic tangential migration (GO:0021826)3.48969984
78substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.48969984
79neuron cell-cell adhesion (GO:0007158)3.44606261
80cellular potassium ion homeostasis (GO:0030007)3.43897181
81regulation of neurotransmitter uptake (GO:0051580)3.41642704
82regulation of dendritic spine development (GO:0060998)3.36904020
83response to histamine (GO:0034776)3.36460271
84mating behavior (GO:0007617)3.36383497
85glycine transport (GO:0015816)3.34190697
86glucocorticoid receptor signaling pathway (GO:0042921)3.33667666
87proline transport (GO:0015824)3.33624338
88sodium ion export (GO:0071436)3.33167583
89visual behavior (GO:0007632)3.32725120
90membrane hyperpolarization (GO:0060081)3.31962785
91mechanosensory behavior (GO:0007638)3.31522827
92negative regulation of amino acid transport (GO:0051956)3.24029022
93learning (GO:0007612)3.24010152
94cell migration in hindbrain (GO:0021535)3.23621762
95membrane depolarization (GO:0051899)3.23087748
96regulation of voltage-gated calcium channel activity (GO:1901385)3.22172089
97positive regulation of synapse maturation (GO:0090129)3.21791189
98regulation of neurotransmitter transport (GO:0051588)3.21701354
99membrane depolarization during action potential (GO:0086010)3.19519456
100dendritic spine organization (GO:0097061)3.19394834
101peptidyl-tyrosine autophosphorylation (GO:0038083)3.18522483
102positive regulation of synaptic transmission (GO:0050806)3.17853608
103negative regulation of dendrite development (GO:2000171)3.17697660
104neuromuscular process (GO:0050905)3.17505307
105female mating behavior (GO:0060180)3.17373598
106fear response (GO:0042596)3.16746468
107neurotransmitter transport (GO:0006836)3.16188370
108regulation of neurotransmitter secretion (GO:0046928)3.15390375
109receptor recycling (GO:0001881)3.13687387
110cAMP metabolic process (GO:0046058)3.12396778
111cyclic nucleotide catabolic process (GO:0009214)3.12350200
112establishment of mitochondrion localization (GO:0051654)3.12176002
113regulation of neurotransmitter levels (GO:0001505)3.11639591
114* G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.05842366
115positive regulation of dendritic spine morphogenesis (GO:0061003)3.00102801
116regulation of guanylate cyclase activity (GO:0031282)2.92822457
117NADH metabolic process (GO:0006734)2.89922999
118corticosteroid receptor signaling pathway (GO:0031958)2.85204658
119regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.83839817
120angiotensin maturation (GO:0002003)2.82009382
121establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.81088565
122mitochondrion transport along microtubule (GO:0047497)2.81088565
123cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.80460559
124regulation of dendrite morphogenesis (GO:0048814)2.69501105
125cerebral cortex neuron differentiation (GO:0021895)2.69226538
126regulation of bile acid biosynthetic process (GO:0070857)2.68840554
127regulation of synapse maturation (GO:0090128)2.68103592
128cell communication by electrical coupling (GO:0010644)2.67917748
129positive regulation of Rap GTPase activity (GO:0032854)2.66344671
130positive regulation of guanylate cyclase activity (GO:0031284)2.59022887
131regulation of Rap GTPase activity (GO:0032317)2.58080627
132protein targeting to plasma membrane (GO:0072661)2.57500854
133cell-cell junction maintenance (GO:0045217)2.52658392
134lipoprotein transport (GO:0042953)2.49701540
135positive regulation of dendritic spine development (GO:0060999)2.49346524
136activation of Rac GTPase activity (GO:0032863)2.48901109
137cellular response to gonadotropin stimulus (GO:0071371)2.44346498
138regulation of glucose import in response to insulin stimulus (GO:2001273)2.43732623
139protein retention in ER lumen (GO:0006621)2.43578648
140actin filament capping (GO:0051693)2.43273230
141embryonic process involved in female pregnancy (GO:0060136)2.43230440
142phosphorelay signal transduction system (GO:0000160)2.42613795
143regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.41203135
144postsynaptic membrane organization (GO:0001941)2.38705813
145regulation of synaptic transmission (GO:0050804)2.37854966
146regulation of vesicle fusion (GO:0031338)2.37555608
147hemoglobin metabolic process (GO:0020027)2.37244121
148urea cycle (GO:0000050)2.36520092
149cell differentiation in hindbrain (GO:0021533)2.35299832
150regulation of nucleobase-containing compound transport (GO:0032239)2.34506526
151endothelial cell chemotaxis (GO:0035767)2.33571851
152regulation of actin nucleation (GO:0051125)2.32473738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.43637745
2* RARB_27405468_Chip-Seq_BRAIN_Mouse4.05712303
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14828684
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.06356978
5MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.05632983
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01660740
7DROSHA_22980978_ChIP-Seq_HELA_Human3.00889438
8GBX2_23144817_ChIP-Seq_PC3_Human2.87340846
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.83516605
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78446460
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78446460
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.76914752
13* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69129823
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.60934009
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58645940
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58566823
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.51505413
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49889923
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.43002449
20* REST_18959480_ChIP-ChIP_MESCs_Mouse2.38838208
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34166295
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26581780
23* EZH2_27294783_Chip-Seq_ESCs_Mouse2.24453307
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.24325305
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21011244
26KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15400751
27ERG_21242973_ChIP-ChIP_JURKAT_Human2.00832558
28* TCF7_22412390_ChIP-Seq_EML_Mouse2.00814610
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.93996387
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90625443
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.89935431
32AR_21572438_ChIP-Seq_LNCaP_Human1.86454374
33MYC_22102868_ChIP-Seq_BL_Human1.85350210
34VDR_21846776_ChIP-Seq_THP-1_Human1.80740133
35GATA1_19941826_ChIP-Seq_K562_Human1.79089269
36NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.73181069
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72757023
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70731631
39* CREB1_26743006_Chip-Seq_LNCaP_Human1.66304714
40RACK7_27058665_Chip-Seq_MCF-7_Human1.60602658
41* KDM2B_26808549_Chip-Seq_K562_Human1.57889862
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.57877413
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55106053
44* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.54880200
45* ELK3_25401928_ChIP-Seq_HUVEC_Human1.54521853
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53891884
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52300019
48* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50994857
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50432038
50* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49948234
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49117576
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44709058
53* TET1_21451524_ChIP-Seq_MESCs_Mouse1.40455994
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.40044809
55* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39670756
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39462054
57P68_20966046_ChIP-Seq_HELA_Human1.38687895
58WT1_25993318_ChIP-Seq_PODOCYTE_Human1.38546199
59RING1B_27294783_Chip-Seq_ESCs_Mouse1.34628116
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34370450
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34265675
62CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.34096220
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.33080015
64* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.32968893
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.32958836
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.31651331
67SMAD4_21799915_ChIP-Seq_A2780_Human1.30817011
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29159363
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29041805
70* GATA1_19941827_ChIP-Seq_MEL_Mouse1.28623089
71AR_19668381_ChIP-Seq_PC3_Human1.26708716
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26033952
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.24848032
74TRIM28_21343339_ChIP-Seq_HEK293_Human1.24596849
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24161770
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24004925
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23251182
78RUNX1_27514584_Chip-Seq_MCF-7_Human1.21785705
79CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.21567325
80PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21487260
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21236443
82RING1B_27294783_Chip-Seq_NPCs_Mouse1.20927182
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.19924227
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17961365
85RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.17083733
86PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15474241
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14373736
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.12923930
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12485398
90* CTCF_27219007_Chip-Seq_Bcells_Human1.11178689
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.10465740
92E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.10305558
93STAT3_23295773_ChIP-Seq_U87_Human1.09990136
94OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.09794040
95TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09653770
96* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09631618
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.09194323
98DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08750071
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07476510
100JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.05664932
101RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05520545
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04580690
103SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04566754
104SMAD3_21741376_ChIP-Seq_HESCs_Human1.04275388
105SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03489679
106* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02930955
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01591233
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00847426
109SMAD_19615063_ChIP-ChIP_OVARY_Human1.00574665
110BCOR_27268052_Chip-Seq_Bcells_Human1.00391273
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.99610078
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99064411
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98592232
114TAF15_26573619_Chip-Seq_HEK293_Human0.96767022
115RXR_22108803_ChIP-Seq_LS180_Human0.96525148
116KLF4_19829295_ChIP-Seq_ESCs_Human0.96385206
117* TP53_22127205_ChIP-Seq_IMR90_Human0.96358446
118GATA2_19941826_ChIP-Seq_K562_Human0.96220508
119VDR_24763502_ChIP-Seq_THP-1_Human0.94557933
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94450149
121EGR1_19374776_ChIP-ChIP_THP-1_Human0.94262033
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93253289
123* KDM2B_26808549_Chip-Seq_DND41_Human0.93144117
124TCF4_23295773_ChIP-Seq_U87_Human0.92834829
125ZNF274_21170338_ChIP-Seq_K562_Hela0.91511069
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.91498822
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90360911
128SMAD4_21741376_ChIP-Seq_HESCs_Human0.90002380
129AHR_22903824_ChIP-Seq_MCF-7_Human0.89965780
130MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89772607
131* KDM2B_26808549_Chip-Seq_JURKAT_Human0.89388968
132AR_25329375_ChIP-Seq_VCAP_Human0.89282841
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.86368679
134RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86236218
135TP53_16413492_ChIP-PET_HCT116_Human0.86009145
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.84318980
137SMC4_20622854_ChIP-Seq_HELA_Human0.83539490
138ARNT_22903824_ChIP-Seq_MCF-7_Human0.81959989
139P300_19829295_ChIP-Seq_ESCs_Human0.81871233
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.81206539
141OCT4_19829295_ChIP-Seq_ESCs_Human0.80683930
142* LXR_22292898_ChIP-Seq_THP-1_Human0.80647872
143PRDM14_20953172_ChIP-Seq_ESCs_Human0.80291706
144DPY_21335234_ChIP-Seq_ESCs_Mouse0.78385087
145THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.77345094

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.54497658
2* MP0002822_catalepsy5.32779755
3* MP0003635_abnormal_synaptic_transmissio4.51102324
4MP0003880_abnormal_central_pattern4.25741603
5MP0004270_analgesia3.84730373
6* MP0009745_abnormal_behavioral_response3.83340047
7MP0002063_abnormal_learning/memory/cond3.80014500
8MP0002064_seizures3.24283557
9MP0002572_abnormal_emotion/affect_behav3.00488014
10MP0009046_muscle_twitch2.90494758
11MP0003183_abnormal_peptide_metabolism2.80266258
12MP0001486_abnormal_startle_reflex2.77508540
13MP0001968_abnormal_touch/_nociception2.69682798
14MP0004147_increased_porphyrin_level2.66072893
15MP0005423_abnormal_somatic_nervous2.64309070
16MP0002272_abnormal_nervous_system2.60132742
17MP0002909_abnormal_adrenal_gland2.51633359
18MP0002734_abnormal_mechanical_nocicepti2.31432806
19MP0001501_abnormal_sleep_pattern2.27916605
20MP0008260_abnormal_autophagy2.01341160
21MP0008569_lethality_at_weaning1.97293147
22MP0005646_abnormal_pituitary_gland1.96568956
23MP0009780_abnormal_chondrocyte_physiolo1.94915471
24* MP0004811_abnormal_neuron_physiology1.89227805
25MP0001970_abnormal_pain_threshold1.85910980
26MP0002733_abnormal_thermal_nociception1.85843796
27MP0005076_abnormal_cell_differentiation1.83362862
28MP0002009_preneoplasia1.83010118
29MP0002736_abnormal_nociception_after1.80381645
30MP0004858_abnormal_nervous_system1.75804447
31MP0002557_abnormal_social/conspecific_i1.74790127
32* MP0004924_abnormal_behavior1.73597317
33* MP0005386_behavior/neurological_phenoty1.73597317
34MP0001440_abnormal_grooming_behavior1.71543721
35MP0001348_abnormal_lacrimal_gland1.68441674
36MP0003329_amyloid_beta_deposits1.67698546
37MP0003879_abnormal_hair_cell1.66243782
38MP0002735_abnormal_chemical_nociception1.60798717
39MP0003075_altered_response_to1.58986508
40MP0002067_abnormal_sensory_capabilities1.57157255
41MP0002249_abnormal_larynx_morphology1.57076825
42MP0008961_abnormal_basal_metabolism1.54508592
43MP0002184_abnormal_innervation1.46809656
44MP0001984_abnormal_olfaction1.45516038
45MP0003633_abnormal_nervous_system1.45415441
46MP0003656_abnormal_erythrocyte_physiolo1.44705812
47MP0000955_abnormal_spinal_cord1.43687871
48* MP0002066_abnormal_motor_capabilities/c1.36717439
49MP0008872_abnormal_physiological_respon1.36387591
50MP0004885_abnormal_endolymph1.32042643
51MP0008874_decreased_physiological_sensi1.31912161
52MP0005360_urolithiasis1.31557163
53MP0005451_abnormal_body_composition1.31351135
54MP0005167_abnormal_blood-brain_barrier1.30514240
55MP0005409_darkened_coat_color1.27694271
56* MP0001529_abnormal_vocalization1.27486615
57MP0002882_abnormal_neuron_morphology1.27286595
58MP0000778_abnormal_nervous_system1.26779943
59MP0003283_abnormal_digestive_organ1.23863656
60MP0003787_abnormal_imprinting1.22890339
61MP0008995_early_reproductive_senescence1.21121703
62MP0001177_atelectasis1.19874742
63MP0009840_abnormal_foam_cell1.18760726
64MP0010234_abnormal_vibrissa_follicle1.17181456
65MP0000569_abnormal_digit_pigmentation1.15825133
66MP0003631_nervous_system_phenotype1.15219957
67MP0001188_hyperpigmentation1.14690314
68MP0009278_abnormal_bone_marrow1.10098071
69MP0000013_abnormal_adipose_tissue1.08503177
70MP0003868_abnormal_feces_composition1.07032962
71MP0002089_abnormal_postnatal_growth/wei1.06287293
72MP0001502_abnormal_circadian_rhythm1.04675004
73MP0002152_abnormal_brain_morphology1.03661467
74MP0005310_abnormal_salivary_gland1.03299057
75MP0002069_abnormal_eating/drinking_beha1.03154840
76MP0005448_abnormal_energy_balance0.99253014
77MP0005666_abnormal_adipose_tissue0.97711110
78MP0003315_abnormal_perineum_morphology0.96451698
79MP0008004_abnormal_stomach_pH0.96417576
80MP0002896_abnormal_bone_mineralization0.94964399
81MP0000747_muscle_weakness0.94888985
82MP0000462_abnormal_digestive_system0.92059942
83MP0005645_abnormal_hypothalamus_physiol0.90353194
84MP0000678_abnormal_parathyroid_gland0.90292191
85MP0001666_abnormal_nutrient_absorption0.88348806
86MP0004145_abnormal_muscle_electrophysio0.88275872
87MP0003690_abnormal_glial_cell0.87419668
88MP0002090_abnormal_vision0.85038541
89MP0005535_abnormal_body_temperature0.84910631
90MP0004264_abnormal_extraembryonic_tissu0.83766405
91* MP0001905_abnormal_dopamine_level0.82902718
92MP0005394_taste/olfaction_phenotype0.82093006
93MP0005499_abnormal_olfactory_system0.82093006
94* MP0004085_abnormal_heartbeat0.81232130
95MP0000537_abnormal_urethra_morphology0.81212423
96MP0004142_abnormal_muscle_tone0.81048578
97MP0000751_myopathy0.79341629
98MP0000604_amyloidosis0.78001739
99MP0003705_abnormal_hypodermis_morpholog0.77142593
100MP0000920_abnormal_myelination0.76007196
101MP0002229_neurodegeneration0.74954335
102MP0005670_abnormal_white_adipose0.73333696
103MP0000538_abnormal_urinary_bladder0.70889663
104MP0005375_adipose_tissue_phenotype0.70861512
105MP0003634_abnormal_glial_cell0.69042186
106MP0003091_abnormal_cell_migration0.68826176
107MP0003632_abnormal_nervous_system0.67437806
108MP0000631_abnormal_neuroendocrine_gland0.67411061
109MP0003172_abnormal_lysosome_physiology0.66842705
110MP0004019_abnormal_vitamin_homeostasis0.65966628
111MP0005166_decreased_susceptibility_to0.65410392
112MP0004233_abnormal_muscle_weight0.63762118
113MP0005623_abnormal_meninges_morphology0.62190392
114MP0003137_abnormal_impulse_conducting0.60491668
115MP0001664_abnormal_digestion0.60395601
116MP0004510_myositis0.59661313
117MP0001485_abnormal_pinna_reflex0.58303716
118MP0004043_abnormal_pH_regulation0.58290379
119MP0003122_maternal_imprinting0.57745310
120MP0003303_peritoneal_inflammation0.52906201
121MP0001943_abnormal_respiration0.52066268
122MP0010769_abnormal_survival0.49763637
123MP0006276_abnormal_autonomic_nervous0.49011313
124MP0004742_abnormal_vestibular_system0.48951362
125* MP0003956_abnormal_body_size0.48878146
126MP0005187_abnormal_penis_morphology0.48542674
127MP0010768_mortality/aging0.46285788
128MP0003861_abnormal_nervous_system0.46040576
129MP0010770_preweaning_lethality0.45391113
130MP0002082_postnatal_lethality0.45391113
131MP0003045_fibrosis0.45269211
132MP0001963_abnormal_hearing_physiology0.44843310
133MP0000003_abnormal_adipose_tissue0.44606514
134MP0002752_abnormal_somatic_nervous0.44428097

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)9.10195259
2Focal motor seizures (HP:0011153)7.38841253
3Focal seizures (HP:0007359)5.71227131
4Visual hallucinations (HP:0002367)4.58159687
5Annular pancreas (HP:0001734)4.49006337
6Action tremor (HP:0002345)4.05227877
7Impaired vibration sensation in the lower limbs (HP:0002166)3.95479584
8Poor eye contact (HP:0000817)3.95449156
9Torticollis (HP:0000473)3.95231013
10Resting tremor (HP:0002322)3.93202018
11Ankle clonus (HP:0011448)3.84459568
12Epileptic encephalopathy (HP:0200134)3.83301060
13Depression (HP:0000716)3.70309678
14Impaired social interactions (HP:0000735)3.59073295
15Abnormal social behavior (HP:0012433)3.59073295
16Anxiety (HP:0000739)3.52014841
17Focal dystonia (HP:0004373)3.49142802
18Urinary bladder sphincter dysfunction (HP:0002839)3.48407641
19Generalized tonic-clonic seizures (HP:0002069)3.46661884
20Broad-based gait (HP:0002136)3.40018371
21Febrile seizures (HP:0002373)3.38725799
22Dysdiadochokinesis (HP:0002075)3.38083189
23Papilledema (HP:0001085)3.37507238
24Gaze-evoked nystagmus (HP:0000640)3.34618960
25Absence seizures (HP:0002121)3.34080454
26Craniofacial dystonia (HP:0012179)3.28645820
27Gonadotropin excess (HP:0000837)3.26621409
28Ankyloglossia (HP:0010296)3.22659299
29Dysmetric saccades (HP:0000641)3.22089345
30Pointed chin (HP:0000307)3.19125073
31Urinary urgency (HP:0000012)3.18794801
32Atonic seizures (HP:0010819)3.16628734
33Progressive cerebellar ataxia (HP:0002073)3.13547336
34Dialeptic seizures (HP:0011146)3.11548142
35Postural instability (HP:0002172)3.07932215
36Stereotypic behavior (HP:0000733)3.07520021
37Dysmetria (HP:0001310)3.06623798
38Impaired smooth pursuit (HP:0007772)3.03651590
39Menstrual irregularities (HP:0000858)2.98834293
40Abnormality of the lower motor neuron (HP:0002366)2.97266595
41Supranuclear gaze palsy (HP:0000605)2.93792200
42Truncal ataxia (HP:0002078)2.92646491
43Abnormality of the phalanges of the hallux (HP:0010057)2.91184889
44Lower limb amyotrophy (HP:0007210)2.87367557
45Scanning speech (HP:0002168)2.81445869
46Split foot (HP:0001839)2.79913804
47Testicular neoplasm (HP:0010788)2.78661184
48Amblyopia (HP:0000646)2.72653318
49Spastic gait (HP:0002064)2.70109196
50Abnormal eating behavior (HP:0100738)2.65270712
51Growth hormone excess (HP:0000845)2.64206251
52Impaired vibratory sensation (HP:0002495)2.63710099
53Reticulocytosis (HP:0001923)2.60797620
54Intention tremor (HP:0002080)2.60222391
55Abnormality of ocular smooth pursuit (HP:0000617)2.57690073
56Relative macrocephaly (HP:0004482)2.57179680
57Bradykinesia (HP:0002067)2.57177763
58Hypercortisolism (HP:0001578)2.55595577
59Abnormality of the distal phalanx of the thumb (HP:0009617)2.53387167
60Mutism (HP:0002300)2.51011781
61Hyperacusis (HP:0010780)2.50120375
62Megalencephaly (HP:0001355)2.49348934
63Abnormality of oral frenula (HP:0000190)2.47695103
64Abnormality of glutamine family amino acid metabolism (HP:0010902)2.45878598
65Abnormality of the fingertips (HP:0001211)2.40023424
66Poikilocytosis (HP:0004447)2.39241710
67Polygenic inheritance (HP:0010982)2.37907210
68Germ cell neoplasia (HP:0100728)2.37669227
69Ventricular fibrillation (HP:0001663)2.35272002
70Hemiplegia (HP:0002301)2.35199210
71Clonus (HP:0002169)2.34558620
72Insomnia (HP:0100785)2.31007476
73Bronchomalacia (HP:0002780)2.29861710
74Precocious puberty (HP:0000826)2.29623197
75Slow saccadic eye movements (HP:0000514)2.28675880
76Abnormal EKG (HP:0003115)2.26662637
77Termporal pattern (HP:0011008)2.25397015
78Insidious onset (HP:0003587)2.25397015
79Prolonged QT interval (HP:0001657)2.23872558
80Peripheral hypomyelination (HP:0007182)2.23695719
81Genetic anticipation (HP:0003743)2.23000650
82Hyperparathyroidism (HP:0000843)2.22911713
83Sleep apnea (HP:0010535)2.19949425
84Acanthocytosis (HP:0001927)2.19768698
85Incomplete penetrance (HP:0003829)2.18571085
86Cerebral inclusion bodies (HP:0100314)2.18335196
87Bundle branch block (HP:0011710)2.15229038
88Abnormality of the aortic arch (HP:0012303)2.15001323
89Hemiparesis (HP:0001269)2.14954697
90Upper limb amyotrophy (HP:0009129)2.14740316
91Distal upper limb amyotrophy (HP:0007149)2.14740316
92Obstructive sleep apnea (HP:0002870)2.14598637
93Lower limb muscle weakness (HP:0007340)2.13247755
94Ileus (HP:0002595)2.11447967
95Epileptiform EEG discharges (HP:0011182)2.10684515
96Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.08960146
97Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.08537676
98Distal lower limb amyotrophy (HP:0008944)2.07458044
99Progressive inability to walk (HP:0002505)2.06416177
100Atrioventricular block (HP:0001678)2.05322029
101Lower limb asymmetry (HP:0100559)2.04533826
102Hyperventilation (HP:0002883)2.04127644
103EEG with generalized epileptiform discharges (HP:0011198)2.04023130
104Status epilepticus (HP:0002133)2.02274729
105Neurofibrillary tangles (HP:0002185)2.01332215
106Hypsarrhythmia (HP:0002521)2.01020890
107Neuronal loss in central nervous system (HP:0002529)1.99453615
108Abnormality of binocular vision (HP:0011514)1.99335088
109Diplopia (HP:0000651)1.99335088
110Elfin facies (HP:0004428)1.99209180
111Abnormality of the periventricular white matter (HP:0002518)1.98625613
112Spinal canal stenosis (HP:0003416)1.96725827
113Excessive salivation (HP:0003781)1.93334621
114Drooling (HP:0002307)1.93334621
115Confusion (HP:0001289)1.93270206
116Limb dystonia (HP:0002451)1.92924753
117Heart block (HP:0012722)1.91120381
118Abnormality of saccadic eye movements (HP:0000570)1.90972822
119Neonatal hypoglycemia (HP:0001998)1.88652089
120Truncus arteriosus (HP:0001660)1.88324807
121Obsessive-compulsive behavior (HP:0000722)1.87216316
122Apathy (HP:0000741)1.84878873
123Hydroxyprolinuria (HP:0003080)1.84067515
124Abnormality of proline metabolism (HP:0010907)1.84067515
125Tetraplegia (HP:0002445)1.83836158
126Gait ataxia (HP:0002066)1.83776127
127Macroorchidism (HP:0000053)1.82966266
128Fetal akinesia sequence (HP:0001989)1.81926019
129Hyperpituitarism (HP:0010514)1.80586116
130Deep palmar crease (HP:0006191)1.80210665
131Intellectual disability, profound (HP:0002187)1.79984737
132Decreased motor nerve conduction velocity (HP:0003431)1.79802009
133Rigidity (HP:0002063)1.78653663
134Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.75580233
135Akinesia (HP:0002304)1.75318973
136Achilles tendon contracture (HP:0001771)1.75086403
137Thin bony cortex (HP:0002753)1.71070994
138Anteriorly placed anus (HP:0001545)1.70658496
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.70287431
140Dementia (HP:0000726)1.70242680
141Long palpebral fissure (HP:0000637)1.70135578
142Gonadal dysgenesis (HP:0000133)1.69743440
143Turricephaly (HP:0000262)1.66865508
144Abnormality of the 1st metacarpal (HP:0010009)1.66464088
145Hammertoe (HP:0001765)1.65645275
146Broad palm (HP:0001169)1.65583062

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.98936680
2NTRK34.40577746
3MAP3K93.89059484
4DAPK23.00920597
5PRKD32.94413176
6KSR22.85339854
7CDK122.69104309
8CAMKK12.44149086
9MAP3K102.38589110
10MINK12.34664704
11SIK12.28804408
12RIPK42.26533508
13EEF2K2.15325116
14MAP3K42.06716353
15PAK62.03764780
16NTRK12.03411586
17TAOK22.00431244
18CAMK1D1.96514311
19KSR11.95651497
20NTRK21.92071273
21MARK11.89003993
22TAOK11.88029932
23DAPK11.76909274
24FES1.69284379
25CDK51.62892711
26MAP3K21.62493585
27MAP3K131.58452448
28TYRO31.56404794
29ARAF1.47222792
30SIK21.42320781
31PRPF4B1.41100638
32MAP2K71.39627529
33CAMK1G1.38105447
34CAMKK21.36490631
35MAP3K111.32335896
36TNIK1.28279992
37SMG11.20970287
38RAF11.19520708
39ALK1.17140974
40TESK11.17086209
41PRKCH1.16115896
42MAP2K41.15366725
43ERN11.14476153
44STK381.12093330
45MAPK151.07683430
46DYRK1B1.05737997
47IRAK20.96768635
48PRKCG0.95998576
49NEK10.95450268
50UHMK10.95037923
51PRKG20.95005163
52RET0.94094227
53STK110.92946037
54CAMK10.91896344
55CDK180.91570750
56SGK4940.91382728
57SGK2230.91382728
58SGK30.90308437
59MARK20.89311747
60CDK150.88582031
61RIPK10.87413230
62MTOR0.86764758
63SGK20.83800791
64CDK140.81297510
65PDK10.81091333
66TRIB30.80479221
67MAP3K10.79232063
68GRK50.78130636
69SGK10.77833549
70CDK11A0.77067851
71PDPK10.74884875
72BRSK10.73995506
73PTK2B0.73637466
74HIPK20.73434943
75PINK10.71041397
76BMPR20.70317772
77SCYL20.69942145
78CAMK2A0.68984973
79PLK20.68941846
80MAPK130.68794268
81INSRR0.68381163
82TESK20.65994965
83MAPK120.64480770
84CDK190.63497969
85CASK0.62743989
86BRD40.61379906
87PAK20.61137517
88LMTK20.60531943
89CAMK2B0.59781307
90PRKAA10.58999351
91TNK20.58371377
92DDR20.58106912
93MAP2K30.57813405
94MAP2K20.57292359
95RPS6KA30.57130680
96CAMK40.57110032
97EIF2AK10.54588329
98MAP3K120.54376456
99MAP2K10.52697188
100MAP3K70.52032788
101DAPK30.51903327
102PRKCI0.51882569
103FYN0.51080946
104IRAK30.50303253
105MAP3K30.48669333
106DMPK0.47136943
107NEK60.47136468
108MAPK100.47128449
109SIK30.46070245
110MAPK110.45773375
111PRKCZ0.45349750
112CDC42BPA0.44028498
113CAMK2G0.43742525
114BRAF0.43614370
115CDK90.43580427
116PRKD20.42799343
117PIM10.41978200
118AKT20.41242653
119FGFR40.40190668
120PDGFRA0.39633331
121GSK3B0.38020032
122LATS20.37294473
123PAK30.37261162
124PRKCB0.36506698
125CHUK0.36439568
126FGFR30.35737135
127PHKG10.35102439
128PHKG20.35102439
129RPS6KA20.33986460
130ICK0.30129327
131DYRK1A0.29756768
132MAPK80.29579160
133BMX0.29097541
134CSNK1G20.27362581
135PNCK0.27091862
136PKN20.26804992
137HCK0.26665842
138MOS0.25831320
139CSNK1A10.25145708
140PRKACG0.24972449
141WNK10.24687746

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047403.47798268
2Nicotine addiction_Homo sapiens_hsa050332.90842710
3Synaptic vesicle cycle_Homo sapiens_hsa047212.78834137
4Circadian entrainment_Homo sapiens_hsa047132.78771582
5Amphetamine addiction_Homo sapiens_hsa050312.71924308
6Long-term potentiation_Homo sapiens_hsa047202.71849697
7Morphine addiction_Homo sapiens_hsa050322.71357305
8GABAergic synapse_Homo sapiens_hsa047272.56532435
9Glutamatergic synapse_Homo sapiens_hsa047242.49633641
10Cocaine addiction_Homo sapiens_hsa050302.39765937
11Dopaminergic synapse_Homo sapiens_hsa047282.35933279
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.32667862
13Salivary secretion_Homo sapiens_hsa049702.12843345
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.05050898
15* Cholinergic synapse_Homo sapiens_hsa047252.05011990
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.02861025
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.97635757
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.93239327
19Insulin secretion_Homo sapiens_hsa049111.89281738
20Gastric acid secretion_Homo sapiens_hsa049711.86911277
21Renin secretion_Homo sapiens_hsa049241.86238354
22Oxytocin signaling pathway_Homo sapiens_hsa049211.78018255
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.77289586
24Calcium signaling pathway_Homo sapiens_hsa040201.66490798
25Nitrogen metabolism_Homo sapiens_hsa009101.57461552
26Gap junction_Homo sapiens_hsa045401.53992349
27Long-term depression_Homo sapiens_hsa047301.53714761
28GnRH signaling pathway_Homo sapiens_hsa049121.52485158
29Serotonergic synapse_Homo sapiens_hsa047261.44589079
30Arginine biosynthesis_Homo sapiens_hsa002201.39771101
31cAMP signaling pathway_Homo sapiens_hsa040241.38749325
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37570602
33Taste transduction_Homo sapiens_hsa047421.33667516
34Glioma_Homo sapiens_hsa052141.33519918
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32755221
36Type II diabetes mellitus_Homo sapiens_hsa049301.23981091
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.19313510
38Estrogen signaling pathway_Homo sapiens_hsa049151.17238900
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.12147950
40cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08167027
41Renin-angiotensin system_Homo sapiens_hsa046141.06417436
42AMPK signaling pathway_Homo sapiens_hsa041521.03766116
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.02879988
44ErbB signaling pathway_Homo sapiens_hsa040121.02607227
45Melanogenesis_Homo sapiens_hsa049161.00728744
46Oocyte meiosis_Homo sapiens_hsa041141.00332090
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.97877246
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95585568
49Non-small cell lung cancer_Homo sapiens_hsa052230.91941566
50Chronic myeloid leukemia_Homo sapiens_hsa052200.91035202
51Vitamin digestion and absorption_Homo sapiens_hsa049770.90232133
52Dorso-ventral axis formation_Homo sapiens_hsa043200.88577406
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.87643929
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86192060
55Axon guidance_Homo sapiens_hsa043600.85431034
56Fatty acid biosynthesis_Homo sapiens_hsa000610.84293180
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.82523674
58Alcoholism_Homo sapiens_hsa050340.82511232
59VEGF signaling pathway_Homo sapiens_hsa043700.81915533
60Pancreatic secretion_Homo sapiens_hsa049720.79651237
61Thyroid hormone synthesis_Homo sapiens_hsa049180.79336215
62Fructose and mannose metabolism_Homo sapiens_hsa000510.78662548
63B cell receptor signaling pathway_Homo sapiens_hsa046620.78474060
64Protein digestion and absorption_Homo sapiens_hsa049740.78177826
65Fat digestion and absorption_Homo sapiens_hsa049750.77799982
66mTOR signaling pathway_Homo sapiens_hsa041500.77498614
67Type I diabetes mellitus_Homo sapiens_hsa049400.76587582
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76314283
69Rap1 signaling pathway_Homo sapiens_hsa040150.75820050
70Dilated cardiomyopathy_Homo sapiens_hsa054140.74937005
71Vitamin B6 metabolism_Homo sapiens_hsa007500.74888493
72MAPK signaling pathway_Homo sapiens_hsa040100.74063174
73* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73834615
74Collecting duct acid secretion_Homo sapiens_hsa049660.73472695
75Choline metabolism in cancer_Homo sapiens_hsa052310.72598830
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.71154592
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69510034
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66901288
79Mineral absorption_Homo sapiens_hsa049780.64782147
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64387708
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62785667
82Acute myeloid leukemia_Homo sapiens_hsa052210.61080405
83Notch signaling pathway_Homo sapiens_hsa043300.60653769
84Chemokine signaling pathway_Homo sapiens_hsa040620.60286021
85Phototransduction_Homo sapiens_hsa047440.58727224
86Glucagon signaling pathway_Homo sapiens_hsa049220.58440287
87Cardiac muscle contraction_Homo sapiens_hsa042600.56702638
88Endometrial cancer_Homo sapiens_hsa052130.56618570
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56582807
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.56072650
91Ras signaling pathway_Homo sapiens_hsa040140.54966933
92Bile secretion_Homo sapiens_hsa049760.53766228
93Endocytosis_Homo sapiens_hsa041440.53563104
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52439110
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51442752
96Insulin resistance_Homo sapiens_hsa049310.50720710
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.50322981
98Pancreatic cancer_Homo sapiens_hsa052120.50082777
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.49526246
100HIF-1 signaling pathway_Homo sapiens_hsa040660.49332384
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48302341
102Galactose metabolism_Homo sapiens_hsa000520.48162334
103Vibrio cholerae infection_Homo sapiens_hsa051100.48137093
104Prion diseases_Homo sapiens_hsa050200.47073326
105Prostate cancer_Homo sapiens_hsa052150.46753791
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46322457
107AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45815382
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.45633498
109Renal cell carcinoma_Homo sapiens_hsa052110.45101912
110Inositol phosphate metabolism_Homo sapiens_hsa005620.44721831
111FoxO signaling pathway_Homo sapiens_hsa040680.43987860
112Insulin signaling pathway_Homo sapiens_hsa049100.43907201
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43891319
114Platelet activation_Homo sapiens_hsa046110.42897924
115Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39444917
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38833050
117Thyroid cancer_Homo sapiens_hsa052160.37602260
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.35699818
119Circadian rhythm_Homo sapiens_hsa047100.34063350
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.33681351
121Prolactin signaling pathway_Homo sapiens_hsa049170.33202152
122Ovarian steroidogenesis_Homo sapiens_hsa049130.33159891
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33091102
124African trypanosomiasis_Homo sapiens_hsa051430.32028707
125Wnt signaling pathway_Homo sapiens_hsa043100.31488594
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30741174
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29854955

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