CHPT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1very-low-density lipoprotein particle assembly (GO:0034379)6.20981299
2presynaptic membrane assembly (GO:0097105)6.04472552
3axon ensheathment in central nervous system (GO:0032291)5.96188356
4central nervous system myelination (GO:0022010)5.96188356
5presynaptic membrane organization (GO:0097090)5.36139231
6neuron cell-cell adhesion (GO:0007158)5.01225377
7iron ion import (GO:0097286)4.98677192
8NADH metabolic process (GO:0006734)4.94110493
9plasma lipoprotein particle assembly (GO:0034377)4.77053210
10alpha-linolenic acid metabolic process (GO:0036109)4.74024755
11angiotensin maturation (GO:0002003)4.73145182
12urea metabolic process (GO:0019627)4.52106895
13regulation of protein activation cascade (GO:2000257)4.45616529
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.43172467
15protein-lipid complex assembly (GO:0065005)4.37774274
16negative regulation of fibrinolysis (GO:0051918)4.35915814
17protoporphyrinogen IX metabolic process (GO:0046501)4.35652450
18fatty acid elongation (GO:0030497)4.29165651
19L-phenylalanine metabolic process (GO:0006558)4.29137907
20erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.29137907
21regulation of complement activation (GO:0030449)4.28779964
22nitrogen cycle metabolic process (GO:0071941)4.27809936
23urea cycle (GO:0000050)4.27443871
24biotin metabolic process (GO:0006768)4.27034145
25epoxygenase P450 pathway (GO:0019373)4.26585368
26L-phenylalanine catabolic process (GO:0006559)4.25034520
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.25034520
28regulation of fibrinolysis (GO:0051917)4.06705057
29postsynaptic membrane organization (GO:0001941)4.06639386
30carnitine shuttle (GO:0006853)4.00769806
31proline biosynthetic process (GO:0006561)3.96149456
32protein carboxylation (GO:0018214)3.92223508
33peptidyl-glutamic acid carboxylation (GO:0017187)3.92223508
34oxaloacetate metabolic process (GO:0006107)3.91189319
35proline metabolic process (GO:0006560)3.86811400
36intestinal absorption (GO:0050892)3.85475903
37cellular glucuronidation (GO:0052695)3.84507484
38regulation of cholesterol esterification (GO:0010872)3.80956444
39complement activation, alternative pathway (GO:0006957)3.77816240
40short-term memory (GO:0007614)3.76547671
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.76259906
42positive regulation of triglyceride lipase activity (GO:0061365)3.73850371
43positive regulation of lipoprotein lipase activity (GO:0051006)3.73850371
44regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.73357492
45amino-acid betaine transport (GO:0015838)3.67606526
46carnitine transport (GO:0015879)3.67606526
47ethanol oxidation (GO:0006069)3.62604165
48plasma lipoprotein particle organization (GO:0071827)3.61283225
49positive regulation of dendritic spine development (GO:0060999)3.61114094
50carnitine transmembrane transport (GO:1902603)3.60898646
51fatty acid transmembrane transport (GO:1902001)3.58893933
52glucuronate metabolic process (GO:0019585)3.57647593
53uronic acid metabolic process (GO:0006063)3.57647593
54protein-lipid complex remodeling (GO:0034368)3.56911512
55macromolecular complex remodeling (GO:0034367)3.56911512
56plasma lipoprotein particle remodeling (GO:0034369)3.56911512
57bile acid metabolic process (GO:0008206)3.52560726
58positive regulation of synapse assembly (GO:0051965)3.51660462
59regulation of triglyceride catabolic process (GO:0010896)3.50683677
60fructose metabolic process (GO:0006000)3.48802392
61regulation of cholesterol metabolic process (GO:0090181)3.47323711
62drug catabolic process (GO:0042737)3.47049368
63protein-lipid complex subunit organization (GO:0071825)3.46874713
64long-chain fatty acid biosynthetic process (GO:0042759)3.44561483
65lipoprotein transport (GO:0042953)3.44274395
66regulation of cholesterol biosynthetic process (GO:0045540)3.43646352
67negative regulation of fatty acid biosynthetic process (GO:0045717)3.42366596
68glyoxylate metabolic process (GO:0046487)3.42231998
69creatine metabolic process (GO:0006600)3.41564723
70hemoglobin metabolic process (GO:0020027)3.40046589
71membrane assembly (GO:0071709)3.39067395
72drug metabolic process (GO:0017144)3.36847346
73cholesterol efflux (GO:0033344)3.36604827
74glutamine family amino acid biosynthetic process (GO:0009084)3.34453068
75phospholipid efflux (GO:0033700)3.34017712
76exogenous drug catabolic process (GO:0042738)3.32699350
77myelination (GO:0042552)3.28907366
78mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.28843736
79regulation of plasminogen activation (GO:0010755)3.27803302
80positive regulation of lipid catabolic process (GO:0050996)3.27006932
81ensheathment of neurons (GO:0007272)3.26526995
82axon ensheathment (GO:0008366)3.26526995
83polyol transport (GO:0015791)3.26322683
84cellular response to epinephrine stimulus (GO:0071872)3.25491078
85quaternary ammonium group transport (GO:0015697)3.25334325
86neuron recognition (GO:0008038)3.25292541
87bile acid and bile salt transport (GO:0015721)3.24710281
88blood coagulation, intrinsic pathway (GO:0007597)3.24122688
89neuronal action potential propagation (GO:0019227)3.23335813
90low-density lipoprotein particle remodeling (GO:0034374)3.21667301
91glutamate metabolic process (GO:0006536)3.21210140
92energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18278183
93ATP synthesis coupled proton transport (GO:0015986)3.18278183
94negative regulation of neurotransmitter transport (GO:0051589)3.17956522
95import into cell (GO:0098657)3.17527903
96regulation of cholesterol homeostasis (GO:2000188)3.16323553
97protein localization to synapse (GO:0035418)3.15389767
98protoporphyrinogen IX biosynthetic process (GO:0006782)3.14512057
99triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.13656290
100transmission of nerve impulse (GO:0019226)3.11974351
101neuron remodeling (GO:0016322)3.11619720
102regulation of bile acid biosynthetic process (GO:0070857)3.11617804
103negative regulation of protein localization to cell surface (GO:2000009)3.11429278
104intestinal cholesterol absorption (GO:0030299)3.10763351
105response to epinephrine (GO:0071871)3.10756668
106regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09937975
107fatty acid homeostasis (GO:0055089)3.09391602
108positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.09362355
109negative regulation of execution phase of apoptosis (GO:1900118)3.08110989
110high-density lipoprotein particle remodeling (GO:0034375)3.05732131
111gamma-aminobutyric acid signaling pathway (GO:0007214)3.05513349
112negative regulation of cholesterol transport (GO:0032375)3.05512383
113negative regulation of sterol transport (GO:0032372)3.05512383
114regulation of dendritic spine development (GO:0060998)3.04803373
115homocysteine metabolic process (GO:0050667)3.01450402
116respiratory electron transport chain (GO:0022904)3.00097873
117ethanol metabolic process (GO:0006067)2.99586015
118short-chain fatty acid metabolic process (GO:0046459)2.99022280
119fat-soluble vitamin biosynthetic process (GO:0042362)2.98568519
120plasma lipoprotein particle clearance (GO:0034381)2.98481645
121regulation of fatty acid biosynthetic process (GO:0042304)2.95959627
122dopamine biosynthetic process (GO:0042416)2.95348443
123fatty acid catabolic process (GO:0009062)2.93439744
124electron transport chain (GO:0022900)2.92078822
125L-amino acid import (GO:0043092)2.91076674
126triglyceride catabolic process (GO:0019433)2.90755455
127acylglycerol homeostasis (GO:0055090)2.90747547
128triglyceride homeostasis (GO:0070328)2.90747547
129nucleoside diphosphate biosynthetic process (GO:0009133)2.90378567
130fatty acid beta-oxidation (GO:0006635)2.89938024
131neutral lipid catabolic process (GO:0046461)2.89881614
132acylglycerol catabolic process (GO:0046464)2.89881614
133bile acid biosynthetic process (GO:0006699)2.89677165
134Golgi to endosome transport (GO:0006895)2.89341319
135low-density lipoprotein particle clearance (GO:0034383)2.88286910
136fatty acid oxidation (GO:0019395)2.88229877
137positive regulation of dendritic spine morphogenesis (GO:0061003)2.87911857
138positive regulation of protein kinase C signaling (GO:0090037)2.87478302
139limb bud formation (GO:0060174)2.87245368
140hormone catabolic process (GO:0042447)2.86881694
141oligodendrocyte differentiation (GO:0048709)2.83076786
142negative regulation of protein activation cascade (GO:2000258)2.83072259
143negative regulation of neurotransmitter secretion (GO:0046929)2.78342711
144dendritic spine morphogenesis (GO:0060997)2.75476881
145cerebral cortex radially oriented cell migration (GO:0021799)2.73525791
146negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.72814542
147amino acid import (GO:0043090)2.71236903
148glutamate receptor signaling pathway (GO:0007215)2.71076874
149regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70814768
150negative regulation of synaptic transmission, GABAergic (GO:0032229)2.70747605
151regulation of pigment cell differentiation (GO:0050932)2.70491252
152positive regulation of cellular amine metabolic process (GO:0033240)2.69905982
153positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.69435673
154regulation of dendritic spine morphogenesis (GO:0061001)2.69186101
155ionotropic glutamate receptor signaling pathway (GO:0035235)2.67999884
156neurotransmitter-gated ion channel clustering (GO:0072578)2.67063001
157glycerophospholipid catabolic process (GO:0046475)2.64995254
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.64659239
159neurotransmitter catabolic process (GO:0042135)2.62234680
160endothelium development (GO:0003158)2.61649604
161response to methylmercury (GO:0051597)2.61611572
162keratinocyte development (GO:0003334)2.60830641
163positive regulation of membrane potential (GO:0045838)2.57927138
164vocalization behavior (GO:0071625)2.57030596
165positive regulation of action potential (GO:0045760)2.56341313
166regulation of protein kinase A signaling (GO:0010738)2.56313534
167retina layer formation (GO:0010842)2.56177924
168regulation of dopamine metabolic process (GO:0042053)2.54397173
169regulation of catecholamine metabolic process (GO:0042069)2.54397173
170regulation of synapse assembly (GO:0051963)2.52526158
171positive regulation of oligodendrocyte differentiation (GO:0048714)2.49066852
172axonal fasciculation (GO:0007413)2.48280954
173positive regulation of systemic arterial blood pressure (GO:0003084)2.47265508
174regulation of feeding behavior (GO:0060259)2.47014813
175eye photoreceptor cell differentiation (GO:0001754)2.46307666
176photoreceptor cell differentiation (GO:0046530)2.46307666
177metanephric tubule development (GO:0072170)2.45966827
178metanephric nephron tubule development (GO:0072234)2.45966827
179positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41843791
180calcium-mediated signaling using intracellular calcium source (GO:0035584)2.40591162
181regulation of respiratory system process (GO:0044065)2.39410733
182mating behavior (GO:0007617)2.39230164
183nucleotide transmembrane transport (GO:1901679)2.38817209
184positive regulation of synaptic transmission, GABAergic (GO:0032230)2.38149804
185substantia nigra development (GO:0021762)2.36784370
186regulation of respiratory gaseous exchange (GO:0043576)2.35933594
187regulation of excitatory postsynaptic membrane potential (GO:0060079)2.34242147
188myelin maintenance (GO:0043217)2.33226492
189righting reflex (GO:0060013)2.30719106
190long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.29611510
191response to dietary excess (GO:0002021)2.28976226
192metanephric nephron epithelium development (GO:0072243)2.28701030
193negative regulation of inclusion body assembly (GO:0090084)2.28562989
194regulation of glutamate secretion (GO:0014048)2.27562358
195positive regulation of protein tyrosine kinase activity (GO:0061098)2.27143514
196regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.26697719
197regulation of postsynaptic membrane potential (GO:0060078)2.24168961
198cilium movement (GO:0003341)2.23177956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.22532545
2* PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.38487845
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.36667787
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.06866321
5EZH2_22144423_ChIP-Seq_EOC_Human3.89296151
6GATA1_22025678_ChIP-Seq_K562_Human3.79871074
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.59037044
8GBX2_23144817_ChIP-Seq_PC3_Human3.43447533
9ZNF263_19887448_ChIP-Seq_K562_Human3.42269402
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.11321571
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.99344632
12AR_21909140_ChIP-Seq_LNCAP_Human2.91017196
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.82581027
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77895834
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.67718067
16* TAF15_26573619_Chip-Seq_HEK293_Human2.67228108
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.50993126
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50113416
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.46438327
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.35554647
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.35159892
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32390548
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30977186
24SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.28345117
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26323471
26RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25968394
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25968394
28* GATA1_19941826_ChIP-Seq_K562_Human2.21609606
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18179915
30CTBP1_25329375_ChIP-Seq_LNCAP_Human2.14616486
31CLOCK_20551151_ChIP-Seq_293T_Human2.11960759
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.09557487
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.07572528
34JARID2_20075857_ChIP-Seq_MESCs_Mouse2.04498105
35VDR_22108803_ChIP-Seq_LS180_Human1.96299918
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96060196
37SOX2_27498859_Chip-Seq_STOMACH_Mouse1.95542237
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95111777
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.95107067
40BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95049058
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.94470256
42* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94040370
43AR_21572438_ChIP-Seq_LNCaP_Human1.93994805
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90730209
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89141308
46* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.83836617
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82834808
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82460844
49* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79127656
50* GATA2_19941826_ChIP-Seq_K562_Human1.78681839
51PIAS1_25552417_ChIP-Seq_VCAP_Human1.78395483
52FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.77455514
53SUZ12_27294783_Chip-Seq_ESCs_Mouse1.76657957
54* CHD1_26751641_Chip-Seq_LNCaP_Human1.75930904
55P300_19829295_ChIP-Seq_ESCs_Human1.75479100
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.75050974
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.73937377
58* FOXA2_19822575_ChIP-Seq_HepG2_Human1.73689188
59VDR_21846776_ChIP-Seq_THP-1_Human1.73400965
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72531824
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.70738968
62* HNF4A_19822575_ChIP-Seq_HepG2_Human1.70450802
63RACK7_27058665_Chip-Seq_MCF-7_Human1.70225832
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.69948649
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69334470
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.65205620
67WT1_19549856_ChIP-ChIP_CCG9911_Human1.64898928
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.63809104
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62431243
70SCL_19346495_ChIP-Seq_HPC-7_Human1.61998592
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.60073843
72ER_23166858_ChIP-Seq_MCF-7_Human1.58946467
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.58523796
74EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.57306868
75STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56317464
76CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.55155512
77* GATA6_25053715_ChIP-Seq_YYC3_Human1.53616565
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52269583
79IGF1R_20145208_ChIP-Seq_DFB_Human1.51705957
80FUS_26573619_Chip-Seq_HEK293_Human1.51468200
81NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51430701
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49270702
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.48965988
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47688595
85* ESR2_21235772_ChIP-Seq_MCF-7_Human1.47516389
86TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46073626
87E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.45476165
88SMAD4_21799915_ChIP-Seq_A2780_Human1.44806973
89LXR_22292898_ChIP-Seq_THP-1_Human1.44589134
90FOXA1_25552417_ChIP-Seq_VCAP_Human1.44303701
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.42962107
92RNF2_27304074_Chip-Seq_NSC_Mouse1.41762754
93GATA1_22383799_ChIP-Seq_G1ME_Mouse1.41421827
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.38127714
95STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36672477
96IRF1_19129219_ChIP-ChIP_H3396_Human1.36472056
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.35238998
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33487341
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.33288045
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31906551
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31541479
102* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.31539724
103EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30348839
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30203399
105ZNF274_21170338_ChIP-Seq_K562_Hela1.30077217
106PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.29635911
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.28883405
108* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.28489794
109CREB1_26743006_Chip-Seq_LNCaP_Human1.25954146
110TCF7_22412390_ChIP-Seq_EML_Mouse1.25155125
111REST_21632747_ChIP-Seq_MESCs_Mouse1.24576613
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23726166
113* NCOR1_26117541_ChIP-Seq_K562_Human1.23092827
114* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21809850
115MYB_21317192_ChIP-Seq_ERMYB_Mouse1.21788161
116FOXO3_23340844_ChIP-Seq_DLD1_Human1.21434244
117* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20815529
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.17978147
119* GATA4_25053715_ChIP-Seq_YYC3_Human1.17947310
120CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17684394
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.17550790
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.17538929
123TP53_18474530_ChIP-ChIP_U2OS_Human1.17187409
124CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.17030716
125ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17021903
126P53_22387025_ChIP-Seq_ESCs_Mouse1.16536848
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.16182069
128SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15535527
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15116550
130P300_18555785_Chip-Seq_ESCs_Mouse1.15100295
131* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14870723
132RUNX2_22187159_ChIP-Seq_PCA_Human1.14739579
133GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.14495830
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14154546
135TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14035904
136NFE2_27457419_Chip-Seq_LIVER_Mouse1.13966529
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13258357
138BCAT_22108803_ChIP-Seq_LS180_Human1.13007078
139AR_25329375_ChIP-Seq_VCAP_Human1.10977582
140KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.10810864
141SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.09966065
142STAT3_23295773_ChIP-Seq_U87_Human1.09623132
143MYC_22102868_ChIP-Seq_BL_Human1.09345842
144PRDM14_20953172_ChIP-Seq_ESCs_Human1.08552417
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.06316447
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05372296
147ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03916239
148TRIM28_21343339_ChIP-Seq_HEK293_Human1.03355652
149KDM2B_26808549_Chip-Seq_REH_Human1.03340346
150SOX2_18555785_Chip-Seq_ESCs_Mouse1.02964645
151TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02763378
152SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02489622
153BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02247362
154DROSHA_22980978_ChIP-Seq_HELA_Human1.02105869
155* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01889856
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01712427
157SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.01684410
158RUNX1_27457419_Chip-Seq_LIVER_Mouse1.01216609
159ATF3_27146783_Chip-Seq_COLON_Human1.00972952
160CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00104065
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99940715
162TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99940715
163SMAD3_21741376_ChIP-Seq_HESCs_Human0.99464557
164IRF8_22096565_ChIP-ChIP_GC-B_Human0.99015540
165NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98984974
166MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98777507
167STAT3_18555785_Chip-Seq_ESCs_Mouse0.98039649
168ARNT_22903824_ChIP-Seq_MCF-7_Human0.97738495
169RING1B_27294783_Chip-Seq_ESCs_Mouse0.97263689
170OCT4_18555785_Chip-Seq_ESCs_Mouse0.96811980
171TCF4_23295773_ChIP-Seq_U87_Human0.96441077
172VDR_24763502_ChIP-Seq_THP-1_Human0.96432861
173EP300_21415370_ChIP-Seq_HL-1_Mouse0.95961058
174* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95051953
175STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93414708
176P68_20966046_ChIP-Seq_HELA_Human0.91978306
177ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91856298
178* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90803593
179* KDM2B_26808549_Chip-Seq_K562_Human0.89929849
180TBX20_22080862_ChIP-Seq_HEART_Mouse0.89164854
181TBX20_22328084_ChIP-Seq_HEART_Mouse0.89164854
182* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89053168
183CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88632899
184TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88437965
185GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88322586
186ELK3_25401928_ChIP-Seq_HUVEC_Human0.87708004
187RARG_19884340_ChIP-ChIP_MEFs_Mouse0.87391692
188KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87063848
189KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85318598
190HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84747811
191KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.84653803
192TBX5_21415370_ChIP-Seq_HL-1_Mouse0.84623278
193TFEB_21752829_ChIP-Seq_HELA_Human0.83858317
194BCOR_27268052_Chip-Seq_Bcells_Human0.83822527
195ETS1_21867929_ChIP-Seq_TH2_Mouse0.83048781
196RUNX1_27514584_Chip-Seq_MCF-7_Human0.81394010
197KDM2B_26808549_Chip-Seq_DND41_Human0.81249842
198SMC4_20622854_ChIP-Seq_HELA_Human0.80806570

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.03651319
2MP0002139_abnormal_hepatobiliary_system5.73411959
3MP0005085_abnormal_gallbladder_physiolo4.16857907
4MP0005365_abnormal_bile_salt4.15799420
5MP0003136_yellow_coat_color3.86161106
6MP0003656_abnormal_erythrocyte_physiolo3.27964209
7MP0005409_darkened_coat_color3.21271077
8MP0009379_abnormal_foot_pigmentation3.14510694
9MP0001666_abnormal_nutrient_absorption2.97353276
10MP0004858_abnormal_nervous_system2.92444998
11MP0004147_increased_porphyrin_level2.83584680
12MP0004381_abnormal_hair_follicle2.78793530
13MP0009840_abnormal_foam_cell2.72760552
14MP0001188_hyperpigmentation2.63925559
15MP0010329_abnormal_lipoprotein_level2.57511813
16MP0006276_abnormal_autonomic_nervous2.51907589
17MP0003868_abnormal_feces_composition2.32848969
18MP0004270_analgesia2.32091883
19MP0003123_paternal_imprinting2.30980309
20MP0000920_abnormal_myelination2.23952548
21MP0005058_abnormal_lysosome_morphology2.21695494
22MP0004742_abnormal_vestibular_system2.17272858
23MP0001486_abnormal_startle_reflex2.11884659
24MP0009745_abnormal_behavioral_response2.11049481
25MP0002064_seizures2.05985419
26MP0003635_abnormal_synaptic_transmissio2.02998060
27MP0001440_abnormal_grooming_behavior1.99400857
28MP0002272_abnormal_nervous_system1.98193828
29MP0000609_abnormal_liver_physiology1.90109091
30MP0009046_muscle_twitch1.88615173
31MP0003183_abnormal_peptide_metabolism1.88018713
32MP0002118_abnormal_lipid_homeostasis1.86359473
33MP0000778_abnormal_nervous_system1.84541155
34MP0001968_abnormal_touch/_nociception1.84416784
35MP0005636_abnormal_mineral_homeostasis1.83389752
36MP0001764_abnormal_homeostasis1.81141223
37MP0001905_abnormal_dopamine_level1.80857168
38MP0003252_abnormal_bile_duct1.74693241
39MP0001529_abnormal_vocalization1.73700434
40MP0004142_abnormal_muscle_tone1.71865189
41MP0002166_altered_tumor_susceptibility1.69203949
42MP0003191_abnormal_cellular_cholesterol1.69082625
43MP0001501_abnormal_sleep_pattern1.67645404
44MP0005423_abnormal_somatic_nervous1.66948784
45MP0003806_abnormal_nucleotide_metabolis1.63120210
46MP0003938_abnormal_ear_development1.61773247
47MP0002572_abnormal_emotion/affect_behav1.60723920
48MP0002067_abnormal_sensory_capabilities1.57679220
49MP0008260_abnormal_autophagy1.57647729
50MP0004233_abnormal_muscle_weight1.57309828
51MP0002734_abnormal_mechanical_nocicepti1.53459949
52MP0002837_dystrophic_cardiac_calcinosis1.44546816
53MP0002063_abnormal_learning/memory/cond1.43948576
54MP0003705_abnormal_hypodermis_morpholog1.41792026
55MP0001661_extended_life_span1.40251970
56MP0004043_abnormal_pH_regulation1.39975452
57MP0004859_abnormal_synaptic_plasticity1.39505148
58MP0004272_abnormal_basement_membrane1.38379190
59MP0004130_abnormal_muscle_cell1.38094949
60MP0006292_abnormal_olfactory_placode1.36235881
61MP0003690_abnormal_glial_cell1.34854228
62MP0005319_abnormal_enzyme/_coenzyme1.34673121
63MP0010234_abnormal_vibrissa_follicle1.34452248
64MP0003172_abnormal_lysosome_physiology1.33970668
65MP0000604_amyloidosis1.32551313
66MP0005408_hypopigmentation1.28471127
67MP0005647_abnormal_sex_gland1.27710734
68MP0005551_abnormal_eye_electrophysiolog1.26500836
69MP0009643_abnormal_urine_homeostasis1.26347400
70MP0002736_abnormal_nociception_after1.24514076
71MP0002009_preneoplasia1.24047117
72MP0005584_abnormal_enzyme/coenzyme_acti1.23784318
73MP0004885_abnormal_endolymph1.23677660
74MP0002876_abnormal_thyroid_physiology1.23668085
75MP0003329_amyloid_beta_deposits1.23017843
76MP0003879_abnormal_hair_cell1.22158861
77MP0006036_abnormal_mitochondrial_physio1.19863133
78MP0004019_abnormal_vitamin_homeostasis1.17321824
79MP0003950_abnormal_plasma_membrane1.17168508
80MP0005083_abnormal_biliary_tract1.16480742
81MP0004145_abnormal_muscle_electrophysio1.16420612
82MP0002557_abnormal_social/conspecific_i1.15614853
83MP0001970_abnormal_pain_threshold1.15010587
84MP0002796_impaired_skin_barrier1.14239592
85MP0000026_abnormal_inner_ear1.12686118
86MP0001485_abnormal_pinna_reflex1.12010127
87MP0000598_abnormal_liver_morphology1.11650844
88MP0002102_abnormal_ear_morphology1.11586877
89MP0001963_abnormal_hearing_physiology1.10219114
90MP0001881_abnormal_mammary_gland1.10120583
91MP0005360_urolithiasis1.09866968
92MP0004484_altered_response_of1.08909304
93MP0005171_absent_coat_pigmentation1.08628922
94MP0005375_adipose_tissue_phenotype1.06866294
95MP0006138_congestive_heart_failure1.06600308
96MP0004264_abnormal_extraembryonic_tissu1.06425707
97MP0005535_abnormal_body_temperature1.05513504
98MP0005386_behavior/neurological_phenoty1.04907429
99MP0004924_abnormal_behavior1.04907429
100MP0002735_abnormal_chemical_nociception1.02685531
101MP0002138_abnormal_hepatobiliary_system1.02080665
102MP0002733_abnormal_thermal_nociception1.01830827
103MP0000566_synostosis1.01634627
104MP0003075_altered_response_to1.00817719
105MP0001765_abnormal_ion_homeostasis1.00230412
106MP0002184_abnormal_innervation1.00101716
107MP0004185_abnormal_adipocyte_glucose0.99960263
108MP0005332_abnormal_amino_acid0.99682649
109MP0009115_abnormal_fat_cell0.99502516
110MP0002066_abnormal_motor_capabilities/c0.99364858
111MP0002229_neurodegeneration0.99310788
112MP0002078_abnormal_glucose_homeostasis0.99252470
113MP0002132_abnormal_respiratory_system0.99092330
114MP0005623_abnormal_meninges_morphology0.98719165
115MP0003634_abnormal_glial_cell0.97295868
116MP0002752_abnormal_somatic_nervous0.96363749
117MP0006072_abnormal_retinal_apoptosis0.96220561
118MP0003186_abnormal_redox_activity0.96159021
119MP0008569_lethality_at_weaning0.95094681
120MP0009697_abnormal_copulation0.94962418
121MP0003724_increased_susceptibility_to0.94527193
122MP0005334_abnormal_fat_pad0.94167135
123MP0005666_abnormal_adipose_tissue0.94096182
124MP0002882_abnormal_neuron_morphology0.93383878
125MP0003195_calcinosis0.91473948
126MP0002971_abnormal_brown_adipose0.88182313
127MP0005330_cardiomyopathy0.86951132
128MP0005379_endocrine/exocrine_gland_phen0.86257589
129MP0005376_homeostasis/metabolism_phenot0.85953263
130MP0005397_hematopoietic_system_phenotyp0.85518504
131MP0001545_abnormal_hematopoietic_system0.85518504
132MP0005670_abnormal_white_adipose0.85183206
133MP0005451_abnormal_body_composition0.85147638
134MP0005448_abnormal_energy_balance0.84641659
135MP0005595_abnormal_vascular_smooth0.84550588
136MP0005165_increased_susceptibility_to0.84148878
137MP0009642_abnormal_blood_homeostasis0.82317524
138MP0000747_muscle_weakness0.80974394
139MP0001984_abnormal_olfaction0.80557716
140MP0000762_abnormal_tongue_morphology0.80313855
141MP0000462_abnormal_digestive_system0.78991800
142MP0000383_abnormal_hair_follicle0.78262664
143MP0010678_abnormal_skin_adnexa0.78015648
144MP0008875_abnormal_xenobiotic_pharmacok0.76884302
145MP0000955_abnormal_spinal_cord0.76689776
146MP0000631_abnormal_neuroendocrine_gland0.76058094
147MP0001177_atelectasis0.75543795
148MP0009384_cardiac_valve_regurgitation0.75500354
149MP0002970_abnormal_white_adipose0.75197814
150MP0003959_abnormal_lean_body0.75135228
151MP0003221_abnormal_cardiomyocyte_apopto0.74994278
152MP0005195_abnormal_posterior_eye0.74879857
153MP0005076_abnormal_cell_differentiation0.74220428
154MP0002006_tumorigenesis0.73596369
155MP0005464_abnormal_platelet_physiology0.73070672
156MP0003953_abnormal_hormone_level0.71986556
157MP0005645_abnormal_hypothalamus_physiol0.71660726
158MP0002152_abnormal_brain_morphology0.71201790
159MP0008469_abnormal_protein_level0.70626892
160MP0000678_abnormal_parathyroid_gland0.70254604
161MP0002638_abnormal_pupillary_reflex0.68348769
162MP0001727_abnormal_embryo_implantation0.68077259
163MP0000230_abnormal_systemic_arterial0.67828078
164MP0009250_abnormal_appendicular_skeleto0.67737076
165MP0005310_abnormal_salivary_gland0.67589149
166MP0004085_abnormal_heartbeat0.66973036
167MP0005410_abnormal_fertilization0.66808914
168MP0002069_abnormal_eating/drinking_beha0.66746939
169MP0010630_abnormal_cardiac_muscle0.63200051
170MP0001664_abnormal_digestion0.62464121
171MP0002822_catalepsy0.62448889
172MP0005166_decreased_susceptibility_to0.60475133
173MP0003718_maternal_effect0.59748968
174MP0000681_abnormal_thyroid_gland0.56084498
175MP0000003_abnormal_adipose_tissue0.55809419
176MP0004947_skin_inflammation0.55198701
177MP0005187_abnormal_penis_morphology0.53853584
178MP0001873_stomach_inflammation0.51724883
179MP0005395_other_phenotype0.51368275
180MP0002877_abnormal_melanocyte_morpholog0.51078525
181MP0004782_abnormal_surfactant_physiolog0.50100880

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.89880183
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.81321956
3Hypobetalipoproteinemia (HP:0003563)4.81113992
4Metabolic alkalosis (HP:0200114)4.53278171
5Complement deficiency (HP:0004431)4.22688710
6Prolonged partial thromboplastin time (HP:0003645)3.95031408
7Acanthocytosis (HP:0001927)3.92369456
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.80689163
9Poikilocytosis (HP:0004447)3.79217588
10Parakeratosis (HP:0001036)3.75060442
11Abnormal ciliary motility (HP:0012262)3.74719462
12Neurofibrillary tangles (HP:0002185)3.72513348
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.66316975
14Focal motor seizures (HP:0011153)3.54946530
15Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.49181276
16Degeneration of the lateral corticospinal tracts (HP:0002314)3.49181276
17Hyperammonemia (HP:0001987)3.46501072
18Abnormality of complement system (HP:0005339)3.45662953
19Abnormal respiratory motile cilium physiology (HP:0012261)3.37089919
20Hyperactive renin-angiotensin system (HP:0000841)3.30517028
21Absent/shortened dynein arms (HP:0200106)3.29759822
22Dynein arm defect of respiratory motile cilia (HP:0012255)3.29759822
23Fat malabsorption (HP:0002630)3.27041201
24Abnormality of renin-angiotensin system (HP:0000847)3.26038480
25Abnormality of the heme biosynthetic pathway (HP:0010472)3.25719249
26Abnormality of glutamine family amino acid metabolism (HP:0010902)3.24767635
27Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.24295557
28Abnormality of chloride homeostasis (HP:0011422)3.23854487
29Polycythemia (HP:0001901)3.23321527
30Increased circulating renin level (HP:0000848)3.20782166
31Cholelithiasis (HP:0001081)3.17843313
32Xanthomatosis (HP:0000991)3.16515029
33Systemic lupus erythematosus (HP:0002725)3.16191128
34Hypomagnesemia (HP:0002917)3.13685735
35Peripheral hypomyelination (HP:0007182)3.11487843
36Sensory axonal neuropathy (HP:0003390)3.07423153
37Optic disc pallor (HP:0000543)3.01163839
38Cerebral inclusion bodies (HP:0100314)3.00392644
39Glomerulonephritis (HP:0000099)2.97583320
40Reticulocytosis (HP:0001923)2.96927159
41Abnormality of secondary sexual hair (HP:0009888)2.92806949
42Abnormality of the axillary hair (HP:0100134)2.92806949
43Hyperventilation (HP:0002883)2.89538682
44Hemorrhage of the eye (HP:0011885)2.85067146
45Conjugated hyperbilirubinemia (HP:0002908)2.84825246
46Joint hemorrhage (HP:0005261)2.83667835
47Hypochromic microcytic anemia (HP:0004840)2.83109361
48Acute necrotizing encephalopathy (HP:0006965)2.82581189
49Excessive salivation (HP:0003781)2.80729405
50Drooling (HP:0002307)2.80729405
51Abnormal gallbladder morphology (HP:0012437)2.77131481
52Hypokalemic alkalosis (HP:0001949)2.73966919
53Abnormal respiratory epithelium morphology (HP:0012253)2.69918584
54Abnormal respiratory motile cilium morphology (HP:0005938)2.69918584
55Nausea (HP:0002018)2.69595701
56Intrahepatic cholestasis (HP:0001406)2.67488692
57Abnormality of the common coagulation pathway (HP:0010990)2.64351460
58Progressive inability to walk (HP:0002505)2.62643275
59Hypolipoproteinemia (HP:0010981)2.62215068
60Acute encephalopathy (HP:0006846)2.60879949
61Progressive macrocephaly (HP:0004481)2.60147221
62Flat acetabular roof (HP:0003180)2.59979339
63Hyperaldosteronism (HP:0000859)2.58345097
64Abnormal gallbladder physiology (HP:0012438)2.56436164
65Cholecystitis (HP:0001082)2.56436164
66Atonic seizures (HP:0010819)2.53503412
67Abnormal drinking behavior (HP:0030082)2.49465077
68Polydipsia (HP:0001959)2.49465077
69Renal Fanconi syndrome (HP:0001994)2.48076862
70Hypoglycemic coma (HP:0001325)2.47278032
71Abnormality of fatty-acid metabolism (HP:0004359)2.45228175
72Generalized aminoaciduria (HP:0002909)2.45079893
73Abnormality of the corticospinal tract (HP:0002492)2.43450084
74Polyuria (HP:0000103)2.40236748
75Neonatal hypoglycemia (HP:0001998)2.36090037
76Abnormality of carpal bone ossification (HP:0006257)2.35978853
77Abnormal tarsal ossification (HP:0008369)2.35857509
78Mitochondrial inheritance (HP:0001427)2.32447099
79Hyperbilirubinemia (HP:0002904)2.32005792
80Abnormality of glycolysis (HP:0004366)2.31505044
81Abnormality of the gallbladder (HP:0005264)2.30247307
82Abnormal mitochondria in muscle tissue (HP:0008316)2.29364814
83Spontaneous abortion (HP:0005268)2.28857441
84Pseudobulbar signs (HP:0002200)2.28451553
85Testicular neoplasm (HP:0010788)2.28063295
86Decreased circulating renin level (HP:0003351)2.27714397
87Ileus (HP:0002595)2.27568753
88Abnormality of magnesium homeostasis (HP:0004921)2.25548817
89Abnormal urine output (HP:0012590)2.25460415
90Broad-based gait (HP:0002136)2.24201634
91Hypochromic anemia (HP:0001931)2.24008662
92Congenital ichthyosiform erythroderma (HP:0007431)2.22420098
93Increased serum pyruvate (HP:0003542)2.21837310
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.21682704
95Confusion (HP:0001289)2.20936559
96Retinal dysplasia (HP:0007973)2.20617231
97Dysmetria (HP:0001310)2.20515840
98Hyperlipoproteinemia (HP:0010980)2.20478405
99Increased hepatocellular lipid droplets (HP:0006565)2.20456934
100Recurrent gram-negative bacterial infections (HP:0005420)2.20118148
101Myocardial infarction (HP:0001658)2.19498662
102Amelogenesis imperfecta (HP:0000705)2.19430292
103Ulnar claw (HP:0001178)2.19348155
104Abnormality of renal resorption (HP:0011038)2.18204300
105Steatorrhea (HP:0002570)2.16762888
106Hydroxyprolinuria (HP:0003080)2.14572139
107Abnormality of proline metabolism (HP:0010907)2.14572139
108Focal seizures (HP:0007359)2.13756014
109Alkalosis (HP:0001948)2.12412244
110Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.11966665
111Sparse lateral eyebrow (HP:0005338)2.11470441
112Hypophosphatemic rickets (HP:0004912)2.10922051
113Muscle hypertrophy of the lower extremities (HP:0008968)2.10412011
114Synostosis involving the elbow (HP:0003938)2.07847399
115Humeroradial synostosis (HP:0003041)2.07847399
116Skin nodule (HP:0200036)2.06944218
117Asymmetric septal hypertrophy (HP:0001670)2.06504644
118Abnormality of renal excretion (HP:0011036)2.06099656
119Mucopolysacchariduria (HP:0008155)2.05438073
120Urinary glycosaminoglycan excretion (HP:0003541)2.05438073
121Metabolic acidosis (HP:0001942)2.05198410
122Cone-rod dystrophy (HP:0000548)2.04632019
123Abnormality of salivation (HP:0100755)2.04482788
124Microcytic anemia (HP:0001935)2.03024750
125Hypercholesterolemia (HP:0003124)2.02451595
126Abnormal hemoglobin (HP:0011902)2.02387575
127Epidermoid cyst (HP:0200040)2.02201943
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.01634005
129Hemiparesis (HP:0001269)2.01121986
130Paraparesis (HP:0002385)2.01016880
131Lipid accumulation in hepatocytes (HP:0006561)2.00798399
132Abnormality of polysaccharide metabolism (HP:0011012)1.98626066
133Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98626066
134Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98626066
135Osteomalacia (HP:0002749)1.98489476
136Abnormality of pyrimidine metabolism (HP:0004353)1.97413318
137Abnormality of the intrinsic pathway (HP:0010989)1.96059718
138Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95532392
139Nonprogressive disorder (HP:0003680)1.95390651
140Proximal tubulopathy (HP:0000114)1.94957496
141Hyperglycinuria (HP:0003108)1.93962465
142Hepatocellular carcinoma (HP:0001402)1.93957966
143Gingival bleeding (HP:0000225)1.93660949
144Thyroid-stimulating hormone excess (HP:0002925)1.93497937
145Rickets (HP:0002748)1.92922523
146Cerebral edema (HP:0002181)1.91950339
147Autoamputation (HP:0001218)1.91663110
148Bundle branch block (HP:0011710)1.91642540
149Concave nail (HP:0001598)1.90804819
150Dysmetric saccades (HP:0000641)1.89973711
151Absent speech (HP:0001344)1.89801143
152Clumsiness (HP:0002312)1.89783564
153Abnormality of glycine metabolism (HP:0010895)1.89532836
154Abnormality of serine family amino acid metabolism (HP:0010894)1.89532836
155Dysostosis multiplex (HP:0000943)1.88511627
156Cerebral hemorrhage (HP:0001342)1.88477429
157Onion bulb formation (HP:0003383)1.85674797
158Dialeptic seizures (HP:0011146)1.85669692
159Rhinitis (HP:0012384)1.85333871
160Leukodystrophy (HP:0002415)1.84941582
161Gastrointestinal infarctions (HP:0005244)1.84629796
162Abnormal urine phosphate concentration (HP:0012599)1.84338938
163Seborrheic dermatitis (HP:0001051)1.82987099
164Nephritis (HP:0000123)1.82126254
165Abnormality of reticulocytes (HP:0004312)1.81614398
166Lower limb hyperreflexia (HP:0002395)1.81113985
167Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.79798404
168Sensorimotor neuropathy (HP:0007141)1.78973142
169Steppage gait (HP:0003376)1.78382076
170Hyperphosphaturia (HP:0003109)1.76956484
171Hyperthyroidism (HP:0000836)1.76948172
172X-linked dominant inheritance (HP:0001423)1.76366085
173Hyperkalemia (HP:0002153)1.76294539
174Thickened helices (HP:0000391)1.76289683
175Hyponatremia (HP:0002902)1.75993711
176Scanning speech (HP:0002168)1.75775287
177Myoglobinuria (HP:0002913)1.75438467
178Thrombophlebitis (HP:0004418)1.75431720
179Malnutrition (HP:0004395)1.74123485
180Abnormality of binocular vision (HP:0011514)1.74117840
181Diplopia (HP:0000651)1.74117840
182Hyperglycinemia (HP:0002154)1.74051456
183Neoplasm of head and neck (HP:0012288)1.73771975
184Esophageal neoplasm (HP:0100751)1.73771975
185Intellectual disability, progressive (HP:0006887)1.73371375
186Abnormality of potassium homeostasis (HP:0011042)1.72099168
187Abnormality of urine glucose concentration (HP:0011016)1.71946650
188Glycosuria (HP:0003076)1.71946650
189Atrioventricular block (HP:0001678)1.71476836
190Abnormality of iron homeostasis (HP:0011031)1.71120796
191Germ cell neoplasia (HP:0100728)1.70907442
192Abnormality of transition element cation homeostasis (HP:0011030)1.70868082
193Ketoacidosis (HP:0001993)1.68522990
194Rhabdomyolysis (HP:0003201)1.67770359

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.81892403
2TRIB34.42526199
3STK394.21862692
4PRKD33.86954543
5AKT33.86571782
6PNCK3.45886353
7OXSR13.39773306
8EEF2K3.21914639
9CAMK1D3.00045346
10ICK2.96013855
11ERN12.91931089
12EIF2AK12.75138789
13WNK42.71930860
14SCYL22.70503927
15TNIK2.58972013
16FGR2.53464264
17PRKD22.17794414
18TNK22.17241249
19EPHA42.10732469
20IRAK32.10675991
21TAOK12.01420464
22MAPK151.97800188
23KSR21.84548107
24PKN21.83593958
25MAP3K21.77843757
26MST41.77042627
27MAP2K31.76483933
28STK381.74502929
29GRK71.74078403
30FES1.57654923
31FGFR31.57163765
32NTRK31.53516080
33IRAK21.48753038
34UHMK11.47762369
35PKN11.47567056
36CAMKK21.43027708
37MUSK1.42835487
38MAPKAPK51.42296827
39WNK11.40143750
40CAMK2B1.38108184
41STK111.36977182
42SIK11.36553252
43PDPK11.36328936
44IRAK11.34492492
45MAP3K11.33889398
46BCR1.33792730
47TAOK21.33305059
48WNK31.33256217
49FGFR41.32372408
50SMG11.31163982
51EPHB11.26185723
52TLK11.24266083
53MAPKAPK31.19893162
54SGK21.16099992
55MAP3K111.14765879
56CAMK2A1.13133204
57SGK31.12981924
58PBK1.10940175
59CLK11.10499947
60NME21.10479560
61CAMK1G1.08098188
62NME11.08040711
63MARK11.06557753
64GRK51.06477741
65CDK121.06318900
66MAP3K31.05769091
67RIPK41.03205135
68MAP2K71.02356506
69NTRK21.01750518
70CSNK1G11.00608617
71ACVR1B0.98787199
72MAP3K40.98731056
73PDK10.98400147
74CDK190.98303499
75PHKG20.97214983
76PHKG10.97214983
77BMPR1B0.92331018
78FGFR20.90168575
79CAMK2D0.89814573
80INSRR0.88728532
81CSNK1G30.88523222
82GRK10.86789883
83RAF10.86443784
84PTK60.86342290
85TRPM70.86118080
86MAP3K130.85609343
87BLK0.85596814
88NLK0.85502263
89ADRBK20.85007711
90RET0.84778706
91GRK60.84553185
92RPS6KB20.84548050
93MAPK130.83760347
94ROCK20.83436749
95MKNK20.82140203
96BMPR20.82059032
97TYK20.78204925
98CAMKK10.77985615
99KDR0.77895170
100FER0.77155549
101MTOR0.75157336
102TIE10.75148173
103YES10.71969847
104CSNK1G20.71542786
105CSNK1A1L0.70835139
106PRKCE0.69978700
107BRSK20.69575830
108PIK3CA0.68717162
109NEK90.67959742
110MAP2K40.67477719
111CDK50.67211723
112NTRK10.66912578
113DYRK20.66438809
114TAOK30.66326797
115NEK60.64224858
116PRKCQ0.63842633
117SGK4940.63444222
118SGK2230.63444222
119CAMK2G0.62801218
120PRKAA20.62309791
121MAP3K60.61183721
122DYRK1A0.61163336
123DMPK0.61089424
124PRKD10.60486483
125STK40.60405120
126MAPK110.60173167
127PAK30.58874015
128CDK70.58157586
129RIPK10.57808485
130PRKAA10.56823476
131CDK30.56129101
132PDK20.54661243
133PTK2B0.54192958
134JAK20.53343842
135HIPK20.52648816
136BRAF0.51839617
137PLK20.51684888
138ILK0.51615957
139TYRO30.51353521
140TSSK60.49402251
141PRKACA0.49159208
142STK160.48917963
143RPS6KB10.48908184
144SIK20.48842454
145MAP3K120.48706727
146CDK60.48506718
147MARK20.48449714
148DYRK30.48418126
149GSK3A0.47317452
150CSK0.46846875
151PRKG10.45877683
152SGK10.45862925
153TBK10.45723359
154EPHB20.45354848
155IRAK40.44883604
156MAPK120.43970078
157PRKACG0.42719514
158MAP3K80.42633284
159OBSCN0.42459846
160MET0.42421952
161PRPF4B0.42235555
162MAP2K20.42175470
163MAP2K10.41459997
164PAK60.40510517
165RPS6KC10.40400016
166RPS6KL10.40400016
167ADRBK10.40013510
168MAP3K50.39299733
169DYRK1B0.38879826
170CDK40.36721431
171PIM10.34729784
172RPS6KA60.32257112
173PRKG20.29458480

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.41979429
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.14850845
3Nicotine addiction_Homo sapiens_hsa050332.98623271
4Fatty acid elongation_Homo sapiens_hsa000622.83658789
5Arginine biosynthesis_Homo sapiens_hsa002202.68991218
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.55642832
7Cyanoamino acid metabolism_Homo sapiens_hsa004602.55117881
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.43624760
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.43476612
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.41564931
11Parkinsons disease_Homo sapiens_hsa050122.32031548
12Alzheimers disease_Homo sapiens_hsa050102.31541446
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.25790388
14Complement and coagulation cascades_Homo sapiens_hsa046102.20923315
15Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.18901572
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12263366
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10801805
18Caffeine metabolism_Homo sapiens_hsa002322.02224886
19Butanoate metabolism_Homo sapiens_hsa006501.98302324
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.91513386
21Steroid biosynthesis_Homo sapiens_hsa001001.85775449
22Fat digestion and absorption_Homo sapiens_hsa049751.85650446
23Drug metabolism - other enzymes_Homo sapiens_hsa009831.84058041
24Renin-angiotensin system_Homo sapiens_hsa046141.83223814
25GABAergic synapse_Homo sapiens_hsa047271.69259206
26Cardiac muscle contraction_Homo sapiens_hsa042601.67966487
27Propanoate metabolism_Homo sapiens_hsa006401.65620099
28Huntingtons disease_Homo sapiens_hsa050161.65374684
29Serotonergic synapse_Homo sapiens_hsa047261.59822474
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.59746336
31Glutamatergic synapse_Homo sapiens_hsa047241.59530121
32Long-term depression_Homo sapiens_hsa047301.54784237
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.53539249
34Sulfur metabolism_Homo sapiens_hsa009201.50793261
35Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.48908293
36Morphine addiction_Homo sapiens_hsa050321.47883149
37Starch and sucrose metabolism_Homo sapiens_hsa005001.45784437
38Axon guidance_Homo sapiens_hsa043601.44341961
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41091568
40Collecting duct acid secretion_Homo sapiens_hsa049661.40480540
41* Ether lipid metabolism_Homo sapiens_hsa005651.40242789
42Taste transduction_Homo sapiens_hsa047421.38567210
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.37808985
44Sphingolipid metabolism_Homo sapiens_hsa006001.37158962
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.37038370
46Carbon metabolism_Homo sapiens_hsa012001.34269140
47Phototransduction_Homo sapiens_hsa047441.33358812
48Renin secretion_Homo sapiens_hsa049241.31754002
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.30711075
50Histidine metabolism_Homo sapiens_hsa003401.26750149
51Fructose and mannose metabolism_Homo sapiens_hsa000511.24131655
52Salivary secretion_Homo sapiens_hsa049701.22453764
53Biosynthesis of amino acids_Homo sapiens_hsa012301.22261637
54Vitamin B6 metabolism_Homo sapiens_hsa007501.19844383
55Other glycan degradation_Homo sapiens_hsa005111.15188113
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.13457252
57Prion diseases_Homo sapiens_hsa050201.12347855
58Fatty acid biosynthesis_Homo sapiens_hsa000611.06682711
59Fatty acid metabolism_Homo sapiens_hsa012121.05823636
60beta-Alanine metabolism_Homo sapiens_hsa004101.03810443
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02037642
62Amphetamine addiction_Homo sapiens_hsa050310.98137685
63Linoleic acid metabolism_Homo sapiens_hsa005910.97640109
64Gastric acid secretion_Homo sapiens_hsa049710.96974282
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96591893
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95250756
67Glycerolipid metabolism_Homo sapiens_hsa005610.95033474
68Dopaminergic synapse_Homo sapiens_hsa047280.94325194
69Calcium signaling pathway_Homo sapiens_hsa040200.92057739
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.91751354
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.91712457
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91603399
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91526202
74Long-term potentiation_Homo sapiens_hsa047200.89505037
75Circadian entrainment_Homo sapiens_hsa047130.86839135
76PPAR signaling pathway_Homo sapiens_hsa033200.85188649
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84714840
78Peroxisome_Homo sapiens_hsa041460.84381149
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84067738
80Mineral absorption_Homo sapiens_hsa049780.83924883
81ABC transporters_Homo sapiens_hsa020100.83813897
82Insulin resistance_Homo sapiens_hsa049310.83118568
83AMPK signaling pathway_Homo sapiens_hsa041520.81799451
84Tyrosine metabolism_Homo sapiens_hsa003500.80738266
85Cocaine addiction_Homo sapiens_hsa050300.79266137
86Steroid hormone biosynthesis_Homo sapiens_hsa001400.77385778
87Pancreatic secretion_Homo sapiens_hsa049720.75121325
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75071394
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73710874
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73480231
91Arachidonic acid metabolism_Homo sapiens_hsa005900.72225575
92Arginine and proline metabolism_Homo sapiens_hsa003300.72188690
93Protein export_Homo sapiens_hsa030600.71065954
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69937272
95Lysine degradation_Homo sapiens_hsa003100.67023140
96Pyruvate metabolism_Homo sapiens_hsa006200.66953043
97Melanogenesis_Homo sapiens_hsa049160.66919571
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.66820642
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.65853898
100Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.65219580
101Dorso-ventral axis formation_Homo sapiens_hsa043200.65068077
102One carbon pool by folate_Homo sapiens_hsa006700.65010471
103Staphylococcus aureus infection_Homo sapiens_hsa051500.64084369
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62696408
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.60515321
106Sulfur relay system_Homo sapiens_hsa041220.60095999
107cAMP signaling pathway_Homo sapiens_hsa040240.59898030
108Cholinergic synapse_Homo sapiens_hsa047250.58968939
109Vitamin digestion and absorption_Homo sapiens_hsa049770.58962512
110Rheumatoid arthritis_Homo sapiens_hsa053230.58692171
111Pentose phosphate pathway_Homo sapiens_hsa000300.57687441
112Phenylalanine metabolism_Homo sapiens_hsa003600.57304618
113Galactose metabolism_Homo sapiens_hsa000520.57255118
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56753587
115Oxytocin signaling pathway_Homo sapiens_hsa049210.55632514
116Ras signaling pathway_Homo sapiens_hsa040140.55338411
117Retinol metabolism_Homo sapiens_hsa008300.55161172
118Renal cell carcinoma_Homo sapiens_hsa052110.54252608
119Fatty acid degradation_Homo sapiens_hsa000710.53792312
120Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53449690
121mTOR signaling pathway_Homo sapiens_hsa041500.52956975
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52402248
123Insulin signaling pathway_Homo sapiens_hsa049100.51826446
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51258187
125Ribosome_Homo sapiens_hsa030100.50365244
126Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49705120
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.49304617
128Non-small cell lung cancer_Homo sapiens_hsa052230.49171380
129* Glycerophospholipid metabolism_Homo sapiens_hsa005640.48448571
130Glucagon signaling pathway_Homo sapiens_hsa049220.47835148
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.47472547
132Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47307743
133* Metabolic pathways_Homo sapiens_hsa011000.45973974
134Wnt signaling pathway_Homo sapiens_hsa043100.45379823
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45030793
136Tight junction_Homo sapiens_hsa045300.44651924
137Autoimmune thyroid disease_Homo sapiens_hsa053200.44077429
138Tryptophan metabolism_Homo sapiens_hsa003800.43778656
139Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40994564
140Vibrio cholerae infection_Homo sapiens_hsa051100.40953213
141Ovarian steroidogenesis_Homo sapiens_hsa049130.40293839
142Bile secretion_Homo sapiens_hsa049760.39873297
143Glutathione metabolism_Homo sapiens_hsa004800.38870328
144Gap junction_Homo sapiens_hsa045400.38156087
145Chemical carcinogenesis_Homo sapiens_hsa052040.38033671
146Acute myeloid leukemia_Homo sapiens_hsa052210.36498917
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34487868
148Thyroid hormone synthesis_Homo sapiens_hsa049180.29831634
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27911260
150Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25853685
151VEGF signaling pathway_Homo sapiens_hsa043700.19533282
152Endometrial cancer_Homo sapiens_hsa052130.19446040
153Chronic myeloid leukemia_Homo sapiens_hsa052200.19119152
154Nitrogen metabolism_Homo sapiens_hsa009100.17471037
155Pancreatic cancer_Homo sapiens_hsa052120.13772328
156Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13123807
157Selenocompound metabolism_Homo sapiens_hsa004500.11597362
158Lysosome_Homo sapiens_hsa041420.11496799

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