CHPF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.84305704
2basement membrane organization (GO:0071711)4.43476027
3COPI coating of Golgi vesicle (GO:0048205)4.19636530
4Golgi transport vesicle coating (GO:0048200)4.19636530
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.91413961
6synaptic vesicle maturation (GO:0016188)3.87371754
7desmosome organization (GO:0002934)3.85057893
8protein heterotrimerization (GO:0070208)3.84205270
9protein retention in ER lumen (GO:0006621)3.81926502
10cell-substrate junction assembly (GO:0007044)3.78714318
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.76691775
12regulation of short-term neuronal synaptic plasticity (GO:0048172)3.72602257
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.68575094
14locomotory exploration behavior (GO:0035641)3.65056025
15regulation of extracellular matrix disassembly (GO:0010715)3.52883158
16cerebellar Purkinje cell layer development (GO:0021680)3.45976309
17collagen fibril organization (GO:0030199)3.43624501
18plasma membrane repair (GO:0001778)3.39659206
19proline biosynthetic process (GO:0006561)3.37612849
20adherens junction assembly (GO:0034333)3.35401964
21layer formation in cerebral cortex (GO:0021819)3.34390427
22semaphorin-plexin signaling pathway (GO:0071526)3.28756776
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.27235994
24cell-substrate adherens junction assembly (GO:0007045)3.22064091
25focal adhesion assembly (GO:0048041)3.22064091
26cell communication by electrical coupling (GO:0010644)3.21682328
27protein carboxylation (GO:0018214)3.21446228
28peptidyl-glutamic acid carboxylation (GO:0017187)3.21446228
29negative regulation of chondrocyte differentiation (GO:0032331)3.20683343
30regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.20457099
31glomerular basement membrane development (GO:0032836)3.14060582
32cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.12820116
33cell adhesion mediated by integrin (GO:0033627)3.12685105
34peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.06126091
35cytoskeletal anchoring at plasma membrane (GO:0007016)3.05714905
36sodium ion export (GO:0071436)3.01060863
37vocalization behavior (GO:0071625)3.00911437
38glutamate secretion (GO:0014047)2.99711720
39regulation of synaptic vesicle exocytosis (GO:2000300)2.98888745
40negative regulation of fatty acid transport (GO:2000192)2.98672711
41bone trabecula formation (GO:0060346)2.96762315
42chondrocyte proliferation (GO:0035988)2.96642977
43endothelial cell morphogenesis (GO:0001886)2.96496922
44activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.95957041
45activation of protein kinase A activity (GO:0034199)2.95692863
46synaptic vesicle exocytosis (GO:0016079)2.94964116
47atrioventricular valve morphogenesis (GO:0003181)2.92997885
48stress fiber assembly (GO:0043149)2.92766010
49proline transport (GO:0015824)2.92651503
50Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.89654600
51sequestering of extracellular ligand from receptor (GO:0035581)2.89298535
52regulation of cholesterol biosynthetic process (GO:0045540)2.89121455
53positive regulation of fibroblast migration (GO:0010763)2.88352517
54adhesion of symbiont to host (GO:0044406)2.87785227
55establishment of apical/basal cell polarity (GO:0035089)2.84546504
56extracellular matrix disassembly (GO:0022617)2.84114286
57cell-cell junction maintenance (GO:0045217)2.82966971
58regulation of synapse structural plasticity (GO:0051823)2.81494437
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.81451740
60regulation of plasminogen activation (GO:0010755)2.78577219
61axon extension involved in axon guidance (GO:0048846)2.77241071
62neuron projection extension involved in neuron projection guidance (GO:1902284)2.77241071
63innervation (GO:0060384)2.76640103
64proline metabolic process (GO:0006560)2.76529802
65peptidyl-proline hydroxylation (GO:0019511)2.76510781
66dermatan sulfate biosynthetic process (GO:0030208)2.76409947
67branching involved in mammary gland duct morphogenesis (GO:0060444)2.76393532
68regulation of cholesterol homeostasis (GO:2000188)2.75955399
69positive regulation of axon extension (GO:0045773)2.74472961
70positive regulation of nuclease activity (GO:0032075)2.74393815
714-hydroxyproline metabolic process (GO:0019471)2.74038353
72regulation of establishment of planar polarity (GO:0090175)2.73573372
73growth hormone secretion (GO:0030252)2.72437270
74negative regulation of catenin import into nucleus (GO:0035414)2.71382891
75dendritic spine morphogenesis (GO:0060997)2.71218896
76protein localization to endosome (GO:0036010)2.70960637
77exploration behavior (GO:0035640)2.70651877
78endothelial cell chemotaxis (GO:0035767)2.70235756
79dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.69011579
80positive regulation of osteoblast proliferation (GO:0033690)2.66915586
81barbed-end actin filament capping (GO:0051016)2.66458692
82establishment of nucleus localization (GO:0040023)2.62234573
83cochlea morphogenesis (GO:0090103)2.61524694
84convergent extension (GO:0060026)2.61211266
85multicellular organismal catabolic process (GO:0044243)2.60533643
86type B pancreatic cell proliferation (GO:0044342)2.60510795
87protein targeting to plasma membrane (GO:0072661)2.60194483
88lung epithelium development (GO:0060428)2.59782389
89multicellular organismal metabolic process (GO:0044236)2.59157671
90vascular endothelial growth factor signaling pathway (GO:0038084)2.57324024
91endocardial cushion development (GO:0003197)2.54686139
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54656743
93positive regulation of synapse maturation (GO:0090129)2.54508329
94protein hydroxylation (GO:0018126)2.53367857
95regulation of early endosome to late endosome transport (GO:2000641)2.52617271
96positive regulation of blood vessel endothelial cell migration (GO:0043536)2.52327698
97regulation of synaptic vesicle transport (GO:1902803)2.51536456
98axonal fasciculation (GO:0007413)2.51299910
99adhesion of symbiont to host cell (GO:0044650)2.51275168
100virion attachment to host cell (GO:0019062)2.51275168
101L-serine transport (GO:0015825)2.50657386
102endodermal cell differentiation (GO:0035987)2.50463391
103cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.50173883
104regulation of neuronal synaptic plasticity (GO:0048168)2.49134504
105activation of Rac GTPase activity (GO:0032863)2.48447099
106extracellular fibril organization (GO:0043206)2.48281816
107extracellular matrix assembly (GO:0085029)2.48132891
108G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.46222542
109polarized epithelial cell differentiation (GO:0030859)2.45902044
110cellular potassium ion homeostasis (GO:0030007)2.45844511
111regulation of cardioblast differentiation (GO:0051890)2.45837839
112tooth mineralization (GO:0034505)2.45812133
113inner ear receptor cell development (GO:0060119)2.45776217
114regulation of extracellular matrix organization (GO:1903053)2.45500241
115apoptotic process involved in morphogenesis (GO:0060561)2.45371416
116extracellular matrix organization (GO:0030198)2.44732991
117vesicle coating (GO:0006901)2.44609170
118dermatan sulfate metabolic process (GO:0030205)2.44323928
119axon extension (GO:0048675)2.44267969
120extracellular structure organization (GO:0043062)2.43640434
121positive regulation of vesicle fusion (GO:0031340)2.43575663
122neurotransmitter secretion (GO:0007269)2.43436788
123dendrite morphogenesis (GO:0048813)2.43436300
124embryo implantation (GO:0007566)2.43106841
125regulation of nuclease activity (GO:0032069)2.42344488
126skin morphogenesis (GO:0043589)2.41924348
127regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.41529778
128cell migration involved in heart development (GO:0060973)2.40501769
129positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.39595031
130endoplasmic reticulum unfolded protein response (GO:0030968)2.37731569
131regulation of apoptotic cell clearance (GO:2000425)2.37422087
132regulation of glucose import in response to insulin stimulus (GO:2001273)2.36586266
133negative regulation of cartilage development (GO:0061037)2.36010752
134regulation of long-term neuronal synaptic plasticity (GO:0048169)2.35392796
135muscle cell migration (GO:0014812)2.35343927
136negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.35013861
137regulation of glutamate receptor signaling pathway (GO:1900449)2.33387005
138regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.33383854
139heparan sulfate proteoglycan metabolic process (GO:0030201)2.33088438
140mesodermal cell differentiation (GO:0048333)2.32776475
141gap junction assembly (GO:0016264)2.31457004
142positive regulation of glycogen biosynthetic process (GO:0045725)2.31255856
143glucose 6-phosphate metabolic process (GO:0051156)2.31103064
144neuromuscular process controlling balance (GO:0050885)2.30966785
145neuron recognition (GO:0008038)2.30944777
146protein maturation by protein folding (GO:0022417)2.30479500
147negative regulation of cell size (GO:0045792)2.29336136
148non-canonical Wnt signaling pathway (GO:0035567)2.29226663
149cellular response to unfolded protein (GO:0034620)2.27801304
150chondrocyte development (GO:0002063)2.27753361
151dendritic spine organization (GO:0097061)2.27406028
152collagen metabolic process (GO:0032963)2.27276110
153collagen catabolic process (GO:0030574)2.25496229
154protein localization to synapse (GO:0035418)2.22895324
155response to pheromone (GO:0019236)2.22581212
156apoptotic cell clearance (GO:0043277)2.20463378
157anatomical structure maturation (GO:0071695)2.19248487
158chondroitin sulfate catabolic process (GO:0030207)2.18548452
159ER-nucleus signaling pathway (GO:0006984)2.18389576
160planar cell polarity pathway involved in neural tube closure (GO:0090179)2.17693703
161insulin-like growth factor receptor signaling pathway (GO:0048009)2.17011072
162multicellular organismal macromolecule metabolic process (GO:0044259)2.16938323
163membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.16475942
164epithelial cell-cell adhesion (GO:0090136)2.15888357
165neuron projection extension (GO:1990138)2.15660872
166cell migration in hindbrain (GO:0021535)2.15166268
167positive regulation of nitric-oxide synthase activity (GO:0051000)2.14681792
168alanine transport (GO:0032328)2.13756934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.69070329
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.36545789
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.54920425
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51601162
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.47757657
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.47757657
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.47132196
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.34237929
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33889231
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.24177197
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.23233305
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.22342201
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.21045700
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.17898601
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13411907
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.13409387
17DROSHA_22980978_ChIP-Seq_HELA_Human2.11672987
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10610240
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.10464573
20* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.09970216
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.06133794
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.05052572
23KDM2B_26808549_Chip-Seq_K562_Human1.98453943
24RNF2_27304074_Chip-Seq_ESCs_Mouse1.97713028
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.92976305
26RARB_27405468_Chip-Seq_BRAIN_Mouse1.90441488
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83440967
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.78296530
29IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77440588
30KDM2B_26808549_Chip-Seq_SUP-B15_Human1.74679520
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74023637
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.68646113
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.68362986
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.65894669
35ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64771032
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.63793994
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61876022
38* LXR_22292898_ChIP-Seq_THP-1_Human1.60077571
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.59780386
40TP53_20018659_ChIP-ChIP_R1E_Mouse1.57692574
41ZFP281_27345836_Chip-Seq_ESCs_Mouse1.56871031
42TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56826995
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.56721341
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55319263
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54597828
46CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54287666
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51766086
48REST_21632747_ChIP-Seq_MESCs_Mouse1.49811979
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.49151932
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.48742796
51TP63_17297297_ChIP-ChIP_HaCaT_Human1.47186656
52CLOCK_20551151_ChIP-Seq_293T_Human1.45793689
53DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45692032
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.42749405
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.42452646
56KDM2B_26808549_Chip-Seq_DND41_Human1.41743173
57DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39117436
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.38881046
59* TET1_21451524_ChIP-Seq_MESCs_Mouse1.38440305
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.37523538
61* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37514207
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.36716814
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.36397127
64SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.35535265
65TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.32803386
66OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32377339
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30920526
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.30531833
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.30413505
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30192640
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.29898087
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.29219485
73UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28767177
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.27923818
75SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27810226
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.27594471
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.26979782
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26917923
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25078075
80TP53_23651856_ChIP-Seq_MEFs_Mouse1.25063434
81* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23974548
82ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23412948
83PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22458104
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22314035
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21336048
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.20512219
87SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20483559
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.20317635
89P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20259857
90KDM2B_26808549_Chip-Seq_JURKAT_Human1.18969455
91TET1_21490601_ChIP-Seq_MESCs_Mouse1.18872534
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.18661227
93NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16984601
94* ELK3_25401928_ChIP-Seq_HUVEC_Human1.15649639
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.15367601
96* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15000615
97RACK7_27058665_Chip-Seq_MCF-7_Human1.14536415
98* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.14300686
99* TCF7_22412390_ChIP-Seq_EML_Mouse1.12770647
100* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12405810
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11155143
102ZNF274_21170338_ChIP-Seq_K562_Hela1.09292995
103NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09096171
104TBX20_22080862_ChIP-Seq_HEART_Mouse1.08956470
105TBX20_22328084_ChIP-Seq_HEART_Mouse1.08956470
106P68_20966046_ChIP-Seq_HELA_Human1.08806839
107CTCF_27219007_Chip-Seq_Bcells_Human1.07831673
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06338465
109AR_21572438_ChIP-Seq_LNCaP_Human1.06167390
110* CREB1_26743006_Chip-Seq_LNCaP_Human1.05956409
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05612329
112TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.05009864
113RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03910509
114CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03660756
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03439606
116* AR_19668381_ChIP-Seq_PC3_Human1.01293624
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00755153
118HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00290782
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00288586
120GBX2_23144817_ChIP-Seq_PC3_Human1.00030002
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99970230
122THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99315468
123SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99084814
124ISL1_27105846_Chip-Seq_CPCs_Mouse0.98832464
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.97980861
126SMC4_20622854_ChIP-Seq_HELA_Human0.97685431
127RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.97486709
128KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96729659
129CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96431392
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96367855
131VDR_21846776_ChIP-Seq_THP-1_Human0.96366499
132KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95185863
133TP63_22573176_ChIP-Seq_HFKS_Human0.95020458
134SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94979574
135SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94098819
136SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.93836158
137SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.93836158
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.93688977
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93501253
140ZNF263_19887448_ChIP-Seq_K562_Human0.93410115
141TP53_22127205_ChIP-Seq_IMR90_Human0.91025258
142KLF4_19829295_ChIP-Seq_ESCs_Human0.88705079
143CJUN_26792858_Chip-Seq_BT549_Human0.88332094
144EGR1_19374776_ChIP-ChIP_THP-1_Human0.87445856
145* ATF3_27146783_Chip-Seq_COLON_Human0.86867286
146HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86847743
147* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.86602633
148ESR1_21235772_ChIP-Seq_MCF-7_Human0.83395669

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.91435585
2MP0004859_abnormal_synaptic_plasticity3.51680349
3MP0005503_abnormal_tendon_morphology3.40051829
4MP0003283_abnormal_digestive_organ3.32087178
5MP0003705_abnormal_hypodermis_morpholog2.97431728
6MP0005275_abnormal_skin_tensile2.93185203
7MP0005623_abnormal_meninges_morphology2.82606564
8MP0000013_abnormal_adipose_tissue2.63879308
9MP0009780_abnormal_chondrocyte_physiolo2.57925354
10MP0003279_aneurysm2.46291067
11MP0004858_abnormal_nervous_system2.32420489
12MP0002909_abnormal_adrenal_gland2.26322261
13MP0001849_ear_inflammation2.26071373
14MP0002060_abnormal_skin_morphology2.14580677
15MP0001958_emphysema2.13537978
16MP0004272_abnormal_basement_membrane2.09012135
17MP0000751_myopathy2.01189360
18MP0003122_maternal_imprinting1.95922365
19MP0003635_abnormal_synaptic_transmissio1.93848079
20MP0000566_synostosis1.91903707
21MP0002877_abnormal_melanocyte_morpholog1.89741815
22MP0005058_abnormal_lysosome_morphology1.84300890
23MP0001299_abnormal_eye_distance/1.80920151
24MP0005257_abnormal_intraocular_pressure1.74906349
25MP0004270_analgesia1.73652142
26MP0009840_abnormal_foam_cell1.68634863
27MP0005409_darkened_coat_color1.67432531
28MP0000579_abnormal_nail_morphology1.62835259
29MP0001348_abnormal_lacrimal_gland1.60307867
30MP0000762_abnormal_tongue_morphology1.56314480
31MP0000003_abnormal_adipose_tissue1.54400287
32MP0002896_abnormal_bone_mineralization1.53118885
33MP0002837_dystrophic_cardiac_calcinosis1.51869085
34MP0005360_urolithiasis1.48866745
35MP0002063_abnormal_learning/memory/cond1.46356862
36MP0002249_abnormal_larynx_morphology1.45520047
37MP0005508_abnormal_skeleton_morphology1.45002372
38MP0000767_abnormal_smooth_muscle1.44840870
39MP0008961_abnormal_basal_metabolism1.42825258
40MP0003329_amyloid_beta_deposits1.37402470
41MP0000534_abnormal_ureter_morphology1.36447030
42MP0004233_abnormal_muscle_weight1.36253714
43MP0002089_abnormal_postnatal_growth/wei1.34615956
44MP0003566_abnormal_cell_adhesion1.34368006
45MP0003941_abnormal_skin_development1.34130263
46MP0003091_abnormal_cell_migration1.32301066
47MP0000467_abnormal_esophagus_morphology1.32063818
48MP0010368_abnormal_lymphatic_system1.28642363
49MP0003045_fibrosis1.28237968
50MP0009384_cardiac_valve_regurgitation1.24374154
51MP0002295_abnormal_pulmonary_circulatio1.24164958
52MP0002108_abnormal_muscle_morphology1.21616327
53MP0005171_absent_coat_pigmentation1.21306507
54MP0000462_abnormal_digestive_system1.21005157
55MP0002234_abnormal_pharynx_morphology1.20761326
56MP0003453_abnormal_keratinocyte_physiol1.17358720
57MP0002734_abnormal_mechanical_nocicepti1.16977013
58MP0003385_abnormal_body_wall1.14204669
59MP0006054_spinal_hemorrhage1.13691533
60MP0010386_abnormal_urinary_bladder1.13588668
61MP0003942_abnormal_urinary_system1.11274448
62MP0008260_abnormal_autophagy1.09544006
63MP0004811_abnormal_neuron_physiology1.07387344
64MP0000955_abnormal_spinal_cord1.07366019
65MP0002733_abnormal_thermal_nociception1.06733716
66MP0003172_abnormal_lysosome_physiology1.06555421
67MP0005076_abnormal_cell_differentiation1.06274886
68MP0009745_abnormal_behavioral_response1.05544666
69MP0002064_seizures1.04758139
70MP0004145_abnormal_muscle_electrophysio1.04719003
71MP0000428_abnormal_craniofacial_morphol1.04335123
72MP0009053_abnormal_anal_canal1.01054296
73MP0010030_abnormal_orbit_morphology1.00903827
74MP0002572_abnormal_emotion/affect_behav1.00874105
75MP0002184_abnormal_innervation1.00857831
76MP0003115_abnormal_respiratory_system1.00731807
77MP0004084_abnormal_cardiac_muscle1.00184864
78MP0001968_abnormal_touch/_nociception0.99315967
79MP0002254_reproductive_system_inflammat0.97781246
80MP0005451_abnormal_body_composition0.96785747
81MP0002735_abnormal_chemical_nociception0.94663454
82MP0005501_abnormal_skin_physiology0.94333252
83MP0003119_abnormal_digestive_system0.94276463
84MP0001915_intracranial_hemorrhage0.94003603
85MP0010352_gastrointestinal_tract_polyps0.93761034
86MP0002796_impaired_skin_barrier0.93326406
87MP0001970_abnormal_pain_threshold0.92999296
88MP0004264_abnormal_extraembryonic_tissu0.90641423
89MP0003880_abnormal_central_pattern0.90484818
90MP0001944_abnormal_pancreas_morphology0.89356616
91MP0000163_abnormal_cartilage_morphology0.87512732
92MP0009250_abnormal_appendicular_skeleto0.87082456
93MP0001243_abnormal_dermal_layer0.86752678
94MP0000538_abnormal_urinary_bladder0.86748624
95MP0000733_abnormal_muscle_development0.86340491
96MP0000747_muscle_weakness0.84137301
97MP0009046_muscle_twitch0.82859357
98MP0008569_lethality_at_weaning0.82724064
99MP0004134_abnormal_chest_morphology0.82270129
100MP0000759_abnormal_skeletal_muscle0.82207225
101MP0003123_paternal_imprinting0.81083543
102MP0000750_abnormal_muscle_regeneration0.80356007
103MP0006138_congestive_heart_failure0.79978245
104MP0010771_integument_phenotype0.79732915
105MP0005197_abnormal_uvea_morphology0.78963734
106MP0000678_abnormal_parathyroid_gland0.78694241
107MP0000778_abnormal_nervous_system0.78281962
108MP0001661_extended_life_span0.77642515
109MP0001440_abnormal_grooming_behavior0.77417644
110MP0002269_muscular_atrophy0.76857433
111MP0005023_abnormal_wound_healing0.76594283
112MP0002116_abnormal_craniofacial_bone0.76458174
113MP0002272_abnormal_nervous_system0.75913825
114MP0004087_abnormal_muscle_fiber0.75342153
115MP0003634_abnormal_glial_cell0.75000160
116MP0002736_abnormal_nociception_after0.74789600
117MP0000858_altered_metastatic_potential0.74287946
118MP0002653_abnormal_ependyma_morphology0.73969679
119MP0000432_abnormal_head_morphology0.73388447
120MP0005375_adipose_tissue_phenotype0.73380624
121MP0002098_abnormal_vibrissa_morphology0.72066693
122MP0002115_abnormal_skeleton_extremities0.70941525
123MP0002557_abnormal_social/conspecific_i0.70713326
124MP0002168_other_aberrant_phenotype0.69986565
125MP0005595_abnormal_vascular_smooth0.69854349
126MP0001501_abnormal_sleep_pattern0.69792863
127MP0002932_abnormal_joint_morphology0.69102361
128MP0002697_abnormal_eye_size0.68467555
129MP0001614_abnormal_blood_vessel0.68409557
130MP0000537_abnormal_urethra_morphology0.68030217
131MP0010234_abnormal_vibrissa_follicle0.67775307
132MP0002882_abnormal_neuron_morphology0.66721401
133MP0005193_abnormal_anterior_eye0.66181114
134MP0000749_muscle_degeneration0.66146332
135MP0005330_cardiomyopathy0.65381997
136MP0001177_atelectasis0.64961658
137MP0006276_abnormal_autonomic_nervous0.64851011
138MP0001542_abnormal_bone_strength0.64704810
139MP0004133_heterotaxia0.64017918
140MP0002113_abnormal_skeleton_development0.63735251
141MP0003959_abnormal_lean_body0.63126004
142MP0010630_abnormal_cardiac_muscle0.62392736
143MP0000049_abnormal_middle_ear0.62359475
144MP0005390_skeleton_phenotype0.61933984
145MP0003755_abnormal_palate_morphology0.61129395

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.87047212
2Premature rupture of membranes (HP:0001788)5.08415561
3Shallow orbits (HP:0000586)3.82405978
4Cerebral aneurysm (HP:0004944)3.73068243
5Bladder diverticulum (HP:0000015)3.54933369
6Ulnar bowing (HP:0003031)3.36270816
7Ankle contracture (HP:0006466)3.32044468
8Broad metatarsal (HP:0001783)3.17038776
9Bowel diverticulosis (HP:0005222)3.05048276
10Dilatation of the ascending aorta (HP:0005111)3.05003393
11Abnormality of dentin (HP:0010299)3.04958428
12Cervical subluxation (HP:0003308)2.96624030
13Wrist flexion contracture (HP:0001239)2.96309240
14Genu recurvatum (HP:0002816)2.94152603
15Atrophic scars (HP:0001075)2.91298348
16Aortic dissection (HP:0002647)2.87032591
17Distal upper limb amyotrophy (HP:0007149)2.83354292
18Upper limb amyotrophy (HP:0009129)2.83354292
19Soft skin (HP:0000977)2.81127196
20Fragile skin (HP:0001030)2.76307298
21Hypercortisolism (HP:0001578)2.64195001
22Hand muscle atrophy (HP:0009130)2.63531869
23Hypoventilation (HP:0002791)2.62157272
24Neonatal short-limb short stature (HP:0008921)2.52386553
25Deep venous thrombosis (HP:0002625)2.51987790
26Aortic aneurysm (HP:0004942)2.50670301
27Hyperextensible skin (HP:0000974)2.49699450
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.49424176
29Congenital glaucoma (HP:0001087)2.45865935
30Premature skin wrinkling (HP:0100678)2.45249163
31Pterygium (HP:0001059)2.44403271
32Peritonitis (HP:0002586)2.42872241
33Mildly elevated creatine phosphokinase (HP:0008180)2.41096381
34Wormian bones (HP:0002645)2.40584839
35Vascular tortuosity (HP:0004948)2.38679393
36Mitral valve prolapse (HP:0001634)2.38299539
37Overgrowth (HP:0001548)2.38054237
38Spinal rigidity (HP:0003306)2.34927384
39Vertebral compression fractures (HP:0002953)2.32940192
40Increased variability in muscle fiber diameter (HP:0003557)2.30598322
41Disproportionate tall stature (HP:0001519)2.26986004
42Mitral stenosis (HP:0001718)2.24728482
43Blue sclerae (HP:0000592)2.24528697
44Abnormality of the Achilles tendon (HP:0005109)2.21355184
45Buphthalmos (HP:0000557)2.20322696
46Difficulty climbing stairs (HP:0003551)2.19274478
47Aneurysm (HP:0002617)2.19192555
48Visual hallucinations (HP:0002367)2.18058077
49Type 1 muscle fiber predominance (HP:0003803)2.17230128
50Abnormal delivery (HP:0001787)2.17036775
51Arterial tortuosity (HP:0005116)2.11949300
52Asymmetry of the thorax (HP:0001555)2.10720487
53Insomnia (HP:0100785)2.09945092
54Short nail (HP:0001799)2.08349045
55Myokymia (HP:0002411)2.07772232
56Generalized amyotrophy (HP:0003700)2.06643507
57Distal lower limb muscle weakness (HP:0009053)2.05898240
58Broad face (HP:0000283)2.04966686
59Bowed forearm bones (HP:0003956)2.02268272
60Bowing of the arm (HP:0006488)2.02268272
61Bronchomalacia (HP:0002780)2.02066905
62Renal duplication (HP:0000075)2.01737894
63Natal tooth (HP:0000695)2.01660897
64Stridor (HP:0010307)2.01328784
65Hyperacusis (HP:0010780)1.99718601
66Follicular hyperkeratosis (HP:0007502)1.98567260
67Focal seizures (HP:0007359)1.95415338
68Supranuclear gaze palsy (HP:0000605)1.95033534
69Deviation of the hallux (HP:0010051)1.94860802
70Turricephaly (HP:0000262)1.94668163
71Spinal cord compression (HP:0002176)1.94566515
72Enlarged penis (HP:0000040)1.93104752
73J-shaped sella turcica (HP:0002680)1.92567635
74Thin bony cortex (HP:0002753)1.92508561
75Coronal craniosynostosis (HP:0004440)1.91920200
76Distal lower limb amyotrophy (HP:0008944)1.91904163
77Increased connective tissue (HP:0009025)1.90662051
78Coxa vara (HP:0002812)1.90359227
79Advanced eruption of teeth (HP:0006288)1.89126206
80Aortic regurgitation (HP:0001659)1.88859710
81Abnormality of carpal bone ossification (HP:0006257)1.88642225
82Abnormality of skeletal muscle fiber size (HP:0012084)1.88199625
83Joint laxity (HP:0001388)1.87843623
84Hallux valgus (HP:0001822)1.86293644
85Osteopenia (HP:0000938)1.86236436
86Slender build (HP:0001533)1.85755468
87Obstructive sleep apnea (HP:0002870)1.85561720
88Broad ribs (HP:0000885)1.84765910
89Achilles tendon contracture (HP:0001771)1.84465543
90Striae distensae (HP:0001065)1.83020755
91Atonic seizures (HP:0010819)1.82524717
92Mild short stature (HP:0003502)1.82000501
93Flat cornea (HP:0007720)1.80356290
94Back pain (HP:0003418)1.80229333
95Long toe (HP:0010511)1.79871749
96Megalencephaly (HP:0001355)1.78671469
97Abnormal ossification of hand bones (HP:0005921)1.78383470
98Biconcave vertebral bodies (HP:0004586)1.78224788
99Abnormality of the acetabulum (HP:0003170)1.77428658
100Renovascular hypertension (HP:0100817)1.77281422
101Cerebral inclusion bodies (HP:0100314)1.75170304
102Osteolytic defects of the hand bones (HP:0009699)1.73889972
103Osteolytic defects of the phalanges of the hand (HP:0009771)1.73889972
104Narrow nasal bridge (HP:0000446)1.73529338
105Thin skin (HP:0000963)1.73349835
106Hemorrhage of the eye (HP:0011885)1.73201105
107Round ear (HP:0100830)1.72068449
108Joint stiffness (HP:0001387)1.71953340
109Arnold-Chiari malformation (HP:0002308)1.71756521
110Flat acetabular roof (HP:0003180)1.70907236
111Lower limb amyotrophy (HP:0007210)1.70385960
112Wide anterior fontanel (HP:0000260)1.69928176
113Cardiovascular calcification (HP:0011915)1.69667690
114Trismus (HP:0000211)1.69025712
115Breech presentation (HP:0001623)1.68725543
116Aplasia involving bones of the upper limbs (HP:0009823)1.68574078
117Aplasia of the phalanges of the hand (HP:0009802)1.68574078
118Aplasia involving bones of the extremities (HP:0009825)1.68574078
119Pointed chin (HP:0000307)1.68525885
120Neoplasm of the heart (HP:0100544)1.67766485
121Osteoarthritis (HP:0002758)1.66882375
122Hyperparathyroidism (HP:0000843)1.66050256
123Elbow flexion contracture (HP:0002987)1.65892157
124Mitral regurgitation (HP:0001653)1.65391948
125Broad long bones (HP:0005622)1.64214087
126Ankyloglossia (HP:0010296)1.63116152
127Ankle clonus (HP:0011448)1.62868100
128Failure to thrive in infancy (HP:0001531)1.61543303
129Agitation (HP:0000713)1.61253509
130Abnormality of the lower motor neuron (HP:0002366)1.60506666
131Depression (HP:0000716)1.60356156
132Papilledema (HP:0001085)1.59151072
133Hemiplegia (HP:0002301)1.58180320
134Thin ribs (HP:0000883)1.58126029
135Scapular winging (HP:0003691)1.54252353
136Thoracolumbar scoliosis (HP:0002944)1.51622670
137Platyspondyly (HP:0000926)1.51542934
138Abnormality of oral frenula (HP:0000190)1.51198916
139Action tremor (HP:0002345)1.50807507
140Inguinal hernia (HP:0000023)1.50521972
141Bradycardia (HP:0001662)1.50307862
142Torticollis (HP:0000473)1.50234862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.06406270
2PRKD33.08517527
3NTRK32.82315105
4MST1R2.81022961
5DDR22.80290471
6PDGFRA2.77376304
7LATS22.71068693
8MAP3K92.63927394
9NTRK12.52837672
10SMG12.51178320
11FGFR42.49189577
12PAK62.16625456
13PKN22.13900915
14KSR22.10353305
15RIPK12.03382375
16SCYL21.88296864
17MINK11.87574752
18PAK31.86132616
19MARK11.76600305
20CAMKK11.68072386
21TTN1.67828095
22MAP3K21.64087194
23IRAK31.63858964
24ERN11.63050012
25MYLK1.62346700
26EPHA41.58241930
27PTK21.54902569
28KSR11.52306817
29CDK121.40355422
30TAOK11.39812846
31BMX1.39181989
32FER1.37863261
33PRKCH1.36747648
34EPHB11.36481345
35TYRO31.34613644
36RET1.31988469
37LMTK21.28680952
38NTRK21.28480971
39SIK11.25048412
40MAP3K41.25027742
41UHMK11.23720425
42EPHB21.23006892
43DAPK21.22939270
44CDC42BPA1.22393351
45NME21.18931903
46ICK1.12922832
47PAK21.07338490
48PIM21.07002665
49PRPF4B1.06045793
50STK381.05912250
51ALK1.05437582
52TESK11.03312213
53ARAF1.01193434
54MAP3K11.00071570
55CDK50.98317448
56MAP2K10.97437854
57PHKG10.94914222
58PHKG20.94914222
59PTK60.94070189
60MAP3K30.92898393
61MAP3K100.91322894
62MUSK0.90714441
63CAMKK20.89589433
64PTK2B0.88708318
65DMPK0.86515106
66PDGFRB0.82964960
67PRKD20.82566982
68MAPKAPK30.80652274
69CDK140.80364048
70LIMK10.79739534
71ROCK10.79573466
72MARK20.79298880
73ERBB40.77224309
74PLK20.76745683
75CDK150.73874773
76CDK180.73673303
77DAPK30.72305448
78HIPK20.72212709
79MAP3K60.71546392
80SIK20.71542184
81MTOR0.71187130
82FGFR10.71068489
83PASK0.69410537
84EEF2K0.67665243
85EPHA30.67262405
86PRKG20.67100420
87TAOK20.66469341
88LATS10.66164727
89MOS0.66149094
90PRKCG0.64444370
91NEK90.64321724
92CDK11A0.62823150
93PDPK10.62138016
94ILK0.61921533
95DYRK1B0.61551651
96RPS6KA20.59950382
97GRK50.57538031
98CAMK1G0.57255071
99CAMK2G0.57210403
100ABL20.57170062
101ROCK20.54638896
102FLT30.54398759
103RPS6KL10.52929744
104RPS6KC10.52929744
105EPHA20.51015522
106MET0.50752642
107FGFR30.49497728
108PRKD10.49080043
109BRAF0.48856959
110MAP2K20.46828006
111PRKCI0.46193897
112CDK70.44979724
113PAK40.42550539
114STK110.41015688
115WNK10.40980588
116CAMK2A0.40153764
117PRKCE0.40126092
118CAMK2B0.39469722
119MAPK150.38618409
120MAPK110.37847942
121SRC0.37424061
122MAP2K40.37111586
123AKT20.36751605
124WNK40.35635161
125GSK3A0.35332826
126CAMK10.35316918
127ADRBK10.34609335
128INSR0.33466801
129CAMK2D0.32366135
130DAPK10.32345668
131RPS6KA60.31856814
132MAP3K80.31627570
133MAP3K110.30976601
134LRRK20.30551053
135MAPKAPK20.29498750
136TGFBR20.29351575
137FYN0.29320669
138PRKCZ0.29313654
139TESK20.28377231

Predicted pathways (KEGG)

RankGene SetZ-score
1Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22055820
2Synaptic vesicle cycle_Homo sapiens_hsa047212.15588834
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.09683317
4Other glycan degradation_Homo sapiens_hsa005112.08932546
5Insulin secretion_Homo sapiens_hsa049111.98179941
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.87381531
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.79183502
8Cyanoamino acid metabolism_Homo sapiens_hsa004601.76548425
9Galactose metabolism_Homo sapiens_hsa000521.68536036
10Circadian entrainment_Homo sapiens_hsa047131.66116739
11Long-term potentiation_Homo sapiens_hsa047201.65536186
12ECM-receptor interaction_Homo sapiens_hsa045121.61633513
13Amphetamine addiction_Homo sapiens_hsa050311.58212057
14Cocaine addiction_Homo sapiens_hsa050301.54182282
15Dilated cardiomyopathy_Homo sapiens_hsa054141.52884982
16Dopaminergic synapse_Homo sapiens_hsa047281.48624039
17Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48478020
18Olfactory transduction_Homo sapiens_hsa047401.46858718
19GABAergic synapse_Homo sapiens_hsa047271.45746153
20Focal adhesion_Homo sapiens_hsa045101.44962331
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.43963251
22Fructose and mannose metabolism_Homo sapiens_hsa000511.43098561
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42995086
24Cholinergic synapse_Homo sapiens_hsa047251.42067714
25Glioma_Homo sapiens_hsa052141.41539904
26Nicotine addiction_Homo sapiens_hsa050331.40435959
27Vibrio cholerae infection_Homo sapiens_hsa051101.39910516
28Estrogen signaling pathway_Homo sapiens_hsa049151.38108939
29Vitamin B6 metabolism_Homo sapiens_hsa007501.38022238
30Notch signaling pathway_Homo sapiens_hsa043301.36382245
31Bladder cancer_Homo sapiens_hsa052191.36078824
32Gap junction_Homo sapiens_hsa045401.35822157
33Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.34462171
34Biosynthesis of amino acids_Homo sapiens_hsa012301.33874379
35Small cell lung cancer_Homo sapiens_hsa052221.32997330
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30594176
37Type II diabetes mellitus_Homo sapiens_hsa049301.30462146
38GnRH signaling pathway_Homo sapiens_hsa049121.28973700
39Salivary secretion_Homo sapiens_hsa049701.28087826
40Gastric acid secretion_Homo sapiens_hsa049711.27663348
41Glutamatergic synapse_Homo sapiens_hsa047241.26234655
42Melanogenesis_Homo sapiens_hsa049161.25120128
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.24847451
44Protein digestion and absorption_Homo sapiens_hsa049741.24370055
45Sulfur relay system_Homo sapiens_hsa041221.23604131
46Morphine addiction_Homo sapiens_hsa050321.22603041
47Pentose phosphate pathway_Homo sapiens_hsa000301.22201634
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.21889464
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19171748
50Complement and coagulation cascades_Homo sapiens_hsa046101.17607933
51Proteoglycans in cancer_Homo sapiens_hsa052051.17173074
52* Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.16259246
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.16056825
54Oxytocin signaling pathway_Homo sapiens_hsa049211.15524738
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15150971
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14219129
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09125648
58Axon guidance_Homo sapiens_hsa043601.08560017
59Neurotrophin signaling pathway_Homo sapiens_hsa047221.07643229
60Hippo signaling pathway_Homo sapiens_hsa043901.07621397
61Arginine biosynthesis_Homo sapiens_hsa002201.04660246
62mTOR signaling pathway_Homo sapiens_hsa041501.02431338
63Amoebiasis_Homo sapiens_hsa051461.02075322
64Taste transduction_Homo sapiens_hsa047421.01921984
65cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01532602
66Renin secretion_Homo sapiens_hsa049241.00280219
67Hedgehog signaling pathway_Homo sapiens_hsa043400.99551283
68Long-term depression_Homo sapiens_hsa047300.99299389
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.99145158
70ErbB signaling pathway_Homo sapiens_hsa040120.98421682
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.97627339
72AMPK signaling pathway_Homo sapiens_hsa041520.97343012
73Endometrial cancer_Homo sapiens_hsa052130.97039340
74Thyroid cancer_Homo sapiens_hsa052160.96973441
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.95187450
76Bile secretion_Homo sapiens_hsa049760.94443918
77Chronic myeloid leukemia_Homo sapiens_hsa052200.93799824
78cAMP signaling pathway_Homo sapiens_hsa040240.93443068
79Thyroid hormone synthesis_Homo sapiens_hsa049180.92568770
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.90530923
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89918061
82Maturity onset diabetes of the young_Homo sapiens_hsa049500.89320761
83VEGF signaling pathway_Homo sapiens_hsa043700.89158883
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.88878186
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87148919
86Prion diseases_Homo sapiens_hsa050200.86103664
87Adherens junction_Homo sapiens_hsa045200.84775886
88Arginine and proline metabolism_Homo sapiens_hsa003300.84753187
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84530214
90MicroRNAs in cancer_Homo sapiens_hsa052060.84261138
91Renal cell carcinoma_Homo sapiens_hsa052110.84166672
92Calcium signaling pathway_Homo sapiens_hsa040200.82789111
93Rap1 signaling pathway_Homo sapiens_hsa040150.82676200
94Type I diabetes mellitus_Homo sapiens_hsa049400.82586790
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81799256
96Wnt signaling pathway_Homo sapiens_hsa043100.81381781
97Phenylalanine metabolism_Homo sapiens_hsa003600.80941491
98Pancreatic secretion_Homo sapiens_hsa049720.80805478
99Phospholipase D signaling pathway_Homo sapiens_hsa040720.80501696
100Basal cell carcinoma_Homo sapiens_hsa052170.80124492
101Dorso-ventral axis formation_Homo sapiens_hsa043200.79145666
102Lysosome_Homo sapiens_hsa041420.79073230
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78877023
104Serotonergic synapse_Homo sapiens_hsa047260.77413863
105Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77211641
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74855582
107Colorectal cancer_Homo sapiens_hsa052100.74571901
108Sphingolipid metabolism_Homo sapiens_hsa006000.74294074
109N-Glycan biosynthesis_Homo sapiens_hsa005100.73936264
110MAPK signaling pathway_Homo sapiens_hsa040100.73821638
111Melanoma_Homo sapiens_hsa052180.72831719
112Glucagon signaling pathway_Homo sapiens_hsa049220.72670223
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71614632
114PPAR signaling pathway_Homo sapiens_hsa033200.71540896
115Insulin signaling pathway_Homo sapiens_hsa049100.71451640
116Prolactin signaling pathway_Homo sapiens_hsa049170.71267746
117Endocytosis_Homo sapiens_hsa041440.70764771
118Carbon metabolism_Homo sapiens_hsa012000.69425805
119Tight junction_Homo sapiens_hsa045300.67897932
120Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67789417
121Lysine degradation_Homo sapiens_hsa003100.67695366
122Insulin resistance_Homo sapiens_hsa049310.67557262
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.66460264
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.64830463
125Pathways in cancer_Homo sapiens_hsa052000.64562040
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64352313
127Prostate cancer_Homo sapiens_hsa052150.63978429
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63872167
129TGF-beta signaling pathway_Homo sapiens_hsa043500.62983601
130Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.62443018
131Ras signaling pathway_Homo sapiens_hsa040140.62435691
132Collecting duct acid secretion_Homo sapiens_hsa049660.61259640
133Non-small cell lung cancer_Homo sapiens_hsa052230.60143609
134Cardiac muscle contraction_Homo sapiens_hsa042600.59836193
135Steroid biosynthesis_Homo sapiens_hsa001000.59671778
136Pancreatic cancer_Homo sapiens_hsa052120.58713104
137Fat digestion and absorption_Homo sapiens_hsa049750.55879634
138Tyrosine metabolism_Homo sapiens_hsa003500.54128287
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.46985295
140Acute myeloid leukemia_Homo sapiens_hsa052210.46616285
141Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45803417
142Inositol phosphate metabolism_Homo sapiens_hsa005620.44587887

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