CHORDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.62791073
2DNA double-strand break processing (GO:0000729)4.36551775
3mitotic sister chromatid cohesion (GO:0007064)4.32948353
4nuclear pore complex assembly (GO:0051292)4.31063527
5nuclear pore organization (GO:0006999)4.19459806
6cullin deneddylation (GO:0010388)4.14878863
7metaphase plate congression (GO:0051310)4.06842995
8nucleobase biosynthetic process (GO:0046112)4.04395468
9DNA strand elongation involved in DNA replication (GO:0006271)4.01642613
10DNA replication initiation (GO:0006270)3.97944831
11ribosomal small subunit assembly (GO:0000028)3.95561878
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.95494867
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.95285263
14mitotic metaphase plate congression (GO:0007080)3.94823742
15negative regulation of DNA-dependent DNA replication (GO:2000104)3.89787194
16replication fork processing (GO:0031297)3.89621845
17telomere maintenance via semi-conservative replication (GO:0032201)3.82440682
18proteasome assembly (GO:0043248)3.82112155
19DNA strand elongation (GO:0022616)3.81066414
20somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80334148
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.80334148
22protein deneddylation (GO:0000338)3.79557471
23deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.75062427
24establishment of integrated proviral latency (GO:0075713)3.74825213
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.70782792
26double-strand break repair via nonhomologous end joining (GO:0006303)3.69727726
27non-recombinational repair (GO:0000726)3.69727726
28CENP-A containing nucleosome assembly (GO:0034080)3.66912272
29histone exchange (GO:0043486)3.66836390
30regulation of DNA endoreduplication (GO:0032875)3.65413005
31regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.64498988
32purine nucleobase biosynthetic process (GO:0009113)3.64237394
33protein neddylation (GO:0045116)3.63688613
34protein localization to kinetochore (GO:0034501)3.61144809
35regulation of mitotic spindle checkpoint (GO:1903504)3.60328489
36regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60328489
37synapsis (GO:0007129)3.58101838
38formation of translation preinitiation complex (GO:0001731)3.57139539
39sister chromatid segregation (GO:0000819)3.57045661
40negative regulation of ligase activity (GO:0051352)3.55645051
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.55645051
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.55245311
43spindle checkpoint (GO:0031577)3.52729693
44DNA ligation (GO:0006266)3.50148271
45somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.49440358
46somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.49440358
47isotype switching (GO:0045190)3.49440358
48ribosome assembly (GO:0042255)3.48460962
49DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46384275
50telomere maintenance via recombination (GO:0000722)3.45560651
51mitotic spindle checkpoint (GO:0071174)3.45267159
52viral mRNA export from host cell nucleus (GO:0046784)3.43857901
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.43099689
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.43099689
55regulation of centriole replication (GO:0046599)3.42717860
56mitotic sister chromatid segregation (GO:0000070)3.40817340
57chromatin remodeling at centromere (GO:0031055)3.38655388
58mitotic recombination (GO:0006312)3.37469900
59signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.36923748
60signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.36923748
61signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.36923748
62centriole replication (GO:0007099)3.33263197
63pore complex assembly (GO:0046931)3.33013543
64maturation of SSU-rRNA (GO:0030490)3.32967628
65nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32823323
66chaperone-mediated protein transport (GO:0072321)3.32751640
67ATP synthesis coupled proton transport (GO:0015986)3.32574063
68energy coupled proton transport, down electrochemical gradient (GO:0015985)3.32574063
697-methylguanosine RNA capping (GO:0009452)3.30747805
70RNA capping (GO:0036260)3.30747805
71regulation of cellular amino acid metabolic process (GO:0006521)3.29428499
72signal transduction involved in DNA damage checkpoint (GO:0072422)3.29387577
73signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29387577
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.29347470
757-methylguanosine mRNA capping (GO:0006370)3.28966223
76histone H2A acetylation (GO:0043968)3.27112588
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.25553562
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.24868710
79attachment of spindle microtubules to kinetochore (GO:0008608)3.24678974
80IMP metabolic process (GO:0046040)3.24670428
81maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.23434750
82IMP biosynthetic process (GO:0006188)3.23027173
83recombinational repair (GO:0000725)3.22531846
84double-strand break repair via homologous recombination (GO:0000724)3.22381885
85negative regulation of mRNA processing (GO:0050686)3.21297255
86resolution of meiotic recombination intermediates (GO:0000712)3.20763449
87spliceosomal snRNP assembly (GO:0000387)3.18567888
88nucleotide-excision repair, DNA gap filling (GO:0006297)3.18279056
89negative regulation of DNA recombination (GO:0045910)3.17507352
90establishment of chromosome localization (GO:0051303)3.16918580
91establishment of protein localization to mitochondrial membrane (GO:0090151)3.16415407
92establishment of viral latency (GO:0019043)3.16072741
93de novo protein folding (GO:0006458)3.16026115
94regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15196525
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.13078192
96negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.13078192
97negative regulation of mitotic sister chromatid segregation (GO:0033048)3.13078192
98negative regulation of mitotic sister chromatid separation (GO:2000816)3.13078192
99negative regulation of sister chromatid segregation (GO:0033046)3.13078192
100DNA damage response, detection of DNA damage (GO:0042769)3.12948600
101DNA catabolic process, exonucleolytic (GO:0000738)3.12422584
102spliceosomal complex assembly (GO:0000245)3.11070274
103de novo posttranslational protein folding (GO:0051084)3.10040028
104meiotic chromosome segregation (GO:0045132)3.09217286
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.08940625
106mitochondrial respiratory chain complex I assembly (GO:0032981)3.08940625
107NADH dehydrogenase complex assembly (GO:0010257)3.08940625
108rRNA processing (GO:0006364)3.08500163
109protein K6-linked ubiquitination (GO:0085020)3.08434316
110negative regulation of chromosome segregation (GO:0051985)3.06997392
111DNA replication checkpoint (GO:0000076)3.06722373
112G1/S transition of mitotic cell cycle (GO:0000082)3.06328314
113cell cycle G1/S phase transition (GO:0044843)3.06328314
114somatic recombination of immunoglobulin gene segments (GO:0016447)3.06038427
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.05759541
116regulation of mitotic metaphase/anaphase transition (GO:0030071)3.05759541
117rRNA modification (GO:0000154)3.05291682
118DNA replication-independent nucleosome organization (GO:0034724)3.04698065
119DNA replication-independent nucleosome assembly (GO:0006336)3.04698065
120sister chromatid cohesion (GO:0007062)3.03308927
121regulation of sister chromatid segregation (GO:0033045)3.03164088
122regulation of mitotic sister chromatid separation (GO:0010965)3.03164088
123regulation of mitotic sister chromatid segregation (GO:0033047)3.03164088
124L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.03054777
125positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.02243111
126antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.02018400
127spindle assembly checkpoint (GO:0071173)3.01073025
128mitotic spindle assembly checkpoint (GO:0007094)3.01061830
129ribosome biogenesis (GO:0042254)3.00495583
130kinetochore assembly (GO:0051382)3.00222254
131DNA deamination (GO:0045006)2.99967683
132negative regulation of mRNA metabolic process (GO:1903312)2.99885156
133DNA topological change (GO:0006265)2.98808932
134regulation of helicase activity (GO:0051095)2.98489480
135regulation of nuclear cell cycle DNA replication (GO:0033262)2.98363830
136termination of RNA polymerase III transcription (GO:0006386)2.98035935
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.98035935
138negative regulation of translation, ncRNA-mediated (GO:0040033)2.97489721
139regulation of translation, ncRNA-mediated (GO:0045974)2.97489721
140negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.97489721
141telomere maintenance via telomerase (GO:0007004)2.97350979
142RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95844438
143protein prenylation (GO:0018342)2.95094808
144prenylation (GO:0097354)2.95094808
145transcription elongation from RNA polymerase I promoter (GO:0006362)2.93047597
146rRNA metabolic process (GO:0016072)2.92673570
147regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.92337891
148telomere maintenance via telomere lengthening (GO:0010833)2.92006784
149protein complex biogenesis (GO:0070271)2.90148283
150ribonucleoprotein complex biogenesis (GO:0022613)2.89424583
151positive regulation of ligase activity (GO:0051351)2.89403229
152DNA replication-dependent nucleosome organization (GO:0034723)2.89334460
153DNA replication-dependent nucleosome assembly (GO:0006335)2.89334460
154somatic diversification of immunoglobulins (GO:0016445)2.89025558
155postreplication repair (GO:0006301)2.87867990
156regulation of chromosome segregation (GO:0051983)2.87634154
157somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.86541814
158somatic cell DNA recombination (GO:0016444)2.86541814
159transcription from mitochondrial promoter (GO:0006390)2.86325069
160folic acid-containing compound biosynthetic process (GO:0009396)2.85954634
161histone mRNA metabolic process (GO:0008334)2.84584644
162ribosomal small subunit biogenesis (GO:0042274)2.84551887
163amino acid activation (GO:0043038)2.84486663
164tRNA aminoacylation (GO:0043039)2.84486663
165kinetochore organization (GO:0051383)2.81927597
166mitochondrial respiratory chain complex assembly (GO:0033108)2.81859925
167tRNA aminoacylation for protein translation (GO:0006418)2.81709325
168translational termination (GO:0006415)2.81004980
169positive regulation of protein homodimerization activity (GO:0090073)2.80631428
170cotranslational protein targeting to membrane (GO:0006613)2.80157207
171response to X-ray (GO:0010165)2.80051668
172mitotic nuclear envelope disassembly (GO:0007077)2.79965875
173transcription-coupled nucleotide-excision repair (GO:0006283)2.78554021
174rRNA methylation (GO:0031167)2.77419374
175translation (GO:0006412)2.76762369
176DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.76758834
177cellular component biogenesis (GO:0044085)2.76590787
178mRNA splicing, via spliceosome (GO:0000398)2.75251843
179RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.75251843
180RNA splicing, via transesterification reactions (GO:0000375)2.74731829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.76447205
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.44852693
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.15806549
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.88110579
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.87625429
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.66857364
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.42915599
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32833348
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.31239946
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.20668435
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.16451875
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15936633
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02811951
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.94666900
15VDR_23849224_ChIP-Seq_CD4+_Human2.84615664
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.80566844
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.74439137
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68905396
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62854342
20* ELK1_19687146_ChIP-ChIP_HELA_Human2.58721400
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56365154
22FOXP3_21729870_ChIP-Seq_TREG_Human2.41912032
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.31531437
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30965562
25* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30095360
26XRN2_22483619_ChIP-Seq_HELA_Human2.29128760
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25941394
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.23392713
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.22921293
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21663726
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.20730888
32ZNF274_21170338_ChIP-Seq_K562_Hela2.20006857
33HOXB4_20404135_ChIP-ChIP_EML_Mouse2.16144353
34DCP1A_22483619_ChIP-Seq_HELA_Human2.14358434
35YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10846906
36VDR_22108803_ChIP-Seq_LS180_Human2.06299828
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.04728575
38* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04562347
39SRF_21415370_ChIP-Seq_HL-1_Mouse2.03783377
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00660549
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98563122
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98466991
43* GABP_19822575_ChIP-Seq_HepG2_Human1.97498354
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97226007
45TTF2_22483619_ChIP-Seq_HELA_Human1.93274574
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.92781627
47* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92029301
48IGF1R_20145208_ChIP-Seq_DFB_Human1.90009946
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.89341003
50FOXM1_23109430_ChIP-Seq_U2OS_Human1.85980274
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.81427609
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73834965
53P300_19829295_ChIP-Seq_ESCs_Human1.71199242
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.71166184
55CIITA_25753668_ChIP-Seq_RAJI_Human1.65904245
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65600581
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.65419738
58MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64575139
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.63786744
60* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63530756
61* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62051016
62BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.58506009
63* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58470460
64* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58049761
65* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53919978
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.48102982
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47392066
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46582849
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46221043
70AR_21909140_ChIP-Seq_LNCAP_Human1.45761678
71PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42351463
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41054387
73* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39886310
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39102902
75* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38269460
76GBX2_23144817_ChIP-Seq_PC3_Human1.37968522
77MYC_18940864_ChIP-ChIP_HL60_Human1.32529038
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.28163638
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.26771175
80* TAF15_26573619_Chip-Seq_HEK293_Human1.26186133
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25121147
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24086589
83EWS_26573619_Chip-Seq_HEK293_Human1.22890014
84* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19886099
85ER_23166858_ChIP-Seq_MCF-7_Human1.19581511
86* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18917411
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17920020
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16676380
89* ELK1_22589737_ChIP-Seq_MCF10A_Human1.16202087
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16084028
91PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15599112
92FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15359220
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15206793
94KDM5A_27292631_Chip-Seq_BREAST_Human1.14844791
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14784257
96IRF1_19129219_ChIP-ChIP_H3396_Human1.14645610
97CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.12987651
98CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12509931
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12025141
100* SPI1_23547873_ChIP-Seq_NB4_Human1.11388121
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.10676584
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07813247
103OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04762927
104* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04254480
105FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.03805009
106* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03660748
107CBP_20019798_ChIP-Seq_JUKART_Human1.03170738
108IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03170738
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.02875307
110* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02462310
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.02173025
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01995567
113BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01409261
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00768595
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.99731068
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98740806
117SMAD4_21799915_ChIP-Seq_A2780_Human0.98409674
118STAT3_23295773_ChIP-Seq_U87_Human0.96582466
119TFEB_21752829_ChIP-Seq_HELA_Human0.95710210
120KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94785561
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94262762
122CRX_20693478_ChIP-Seq_RETINA_Mouse0.93166264
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92721380
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92545137
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.92332170
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92067336
127GATA1_22025678_ChIP-Seq_K562_Human0.91360397
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91290887
129P300_18555785_Chip-Seq_ESCs_Mouse0.91179873
130EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91102502
131P53_22387025_ChIP-Seq_ESCs_Mouse0.90992190
132CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90698507
133* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90605098
134FUS_26573619_Chip-Seq_HEK293_Human0.90595538
135NANOG_19829295_ChIP-Seq_ESCs_Human0.90526961
136SOX2_19829295_ChIP-Seq_ESCs_Human0.90526961
137TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90307176
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90307176
139SOX9_26525672_Chip-Seq_HEART_Mouse0.89951747
140MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89045391
141* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87454734
142* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.85372857
143TP63_19390658_ChIP-ChIP_HaCaT_Human0.84736436
144NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82707504
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.81460948
146STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80196058
147SALL4_22934838_ChIP-ChIP_CD34+_Human0.78234042
148CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76927701
149KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74045662
150* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.73530154
151SOX2_16153702_ChIP-ChIP_HESCs_Human0.72815141
152ELF5_23300383_ChIP-Seq_T47D_Human0.69338586
153SOX2_18555785_ChIP-Seq_MESCs_Mouse0.67054598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.89798240
2MP0001529_abnormal_vocalization4.72730577
3MP0003693_abnormal_embryo_hatching3.92266954
4MP0010094_abnormal_chromosome_stability3.71528142
5* MP0004957_abnormal_blastocyst_morpholog3.24991000
6MP0008058_abnormal_DNA_repair3.04507786
7MP0002396_abnormal_hematopoietic_system3.03773533
8MP0003077_abnormal_cell_cycle2.87415690
9MP0009697_abnormal_copulation2.75317121
10MP0005671_abnormal_response_to2.58977561
11MP0003121_genomic_imprinting2.51926932
12MP0003111_abnormal_nucleus_morphology2.39480822
13MP0003122_maternal_imprinting2.37305063
14MP0008007_abnormal_cellular_replicative2.33761035
15MP0006054_spinal_hemorrhage2.32646029
16* MP0008932_abnormal_embryonic_tissue2.21387801
17MP0008877_abnormal_DNA_methylation2.18611106
18MP0006276_abnormal_autonomic_nervous2.10674761
19MP0001905_abnormal_dopamine_level2.06344961
20MP0000569_abnormal_digit_pigmentation1.99303733
21MP0004147_increased_porphyrin_level1.99003200
22MP0003123_paternal_imprinting1.90518795
23MP0003880_abnormal_central_pattern1.89130626
24MP0006035_abnormal_mitochondrial_morpho1.82675525
25MP0010307_abnormal_tumor_latency1.81807283
26MP0003787_abnormal_imprinting1.78709813
27MP0006072_abnormal_retinal_apoptosis1.75200154
28MP0003763_abnormal_thymus_physiology1.73658083
29MP0003937_abnormal_limbs/digits/tail_de1.72305221
30MP0006036_abnormal_mitochondrial_physio1.64424345
31MP0009333_abnormal_splenocyte_physiolog1.61403826
32MP0003806_abnormal_nucleotide_metabolis1.58083365
33MP0002398_abnormal_bone_marrow1.51409691
34MP0001293_anophthalmia1.48710553
35MP0006292_abnormal_olfactory_placode1.45243095
36MP0000350_abnormal_cell_proliferation1.44104955
37MP0005253_abnormal_eye_physiology1.39961030
38MP0001986_abnormal_taste_sensitivity1.34993513
39MP0003786_premature_aging1.33484076
40MP0004142_abnormal_muscle_tone1.33086356
41MP0001730_embryonic_growth_arrest1.32421326
42MP0000490_abnormal_crypts_of1.31221436
43MP0001929_abnormal_gametogenesis1.30246767
44MP0005367_renal/urinary_system_phenotyp1.27961171
45MP0000516_abnormal_urinary_system1.27961171
46MP0001286_abnormal_eye_development1.27703564
47MP0009785_altered_susceptibility_to1.26565208
48MP0002210_abnormal_sex_determination1.25003232
49MP0000689_abnormal_spleen_morphology1.23236790
50MP0000703_abnormal_thymus_morphology1.22668798
51MP0002009_preneoplasia1.22332814
52MP0005075_abnormal_melanosome_morpholog1.21825546
53MP0002722_abnormal_immune_system1.20685500
54MP0003195_calcinosis1.19375413
55MP0005551_abnormal_eye_electrophysiolog1.17708622
56MP0002420_abnormal_adaptive_immunity1.16868115
57MP0003119_abnormal_digestive_system1.16238783
58MP0000716_abnormal_immune_system1.15842812
59MP0002429_abnormal_blood_cell1.14849825
60MP0001800_abnormal_humoral_immune1.14544120
61MP0000427_abnormal_hair_cycle1.14366852
62MP0002735_abnormal_chemical_nociception1.13802561
63MP0005000_abnormal_immune_tolerance1.12081189
64MP0001819_abnormal_immune_cell1.12025825
65MP0005266_abnormal_metabolism1.11980073
66MP0003567_abnormal_fetal_cardiomyocyte1.10915894
67MP0002234_abnormal_pharynx_morphology1.10707670
68MP0002084_abnormal_developmental_patter1.09819043
69MP0000653_abnormal_sex_gland1.09341020
70MP0000647_abnormal_sebaceous_gland1.09173611
71MP0009703_decreased_birth_body1.08169266
72MP0004215_abnormal_myocardial_fiber1.07820659
73MP0001145_abnormal_male_reproductive1.07147626
74MP0003941_abnormal_skin_development1.06801095
75MP0001727_abnormal_embryo_implantation1.06488940
76MP0002233_abnormal_nose_morphology1.05124286
77MP0000313_abnormal_cell_death1.05095687
78MP0010352_gastrointestinal_tract_polyps1.04543506
79MP0001188_hyperpigmentation1.04328968
80MP0003315_abnormal_perineum_morphology1.03603560
81MP0002723_abnormal_immune_serum1.03474981
82MP0003950_abnormal_plasma_membrane1.03071347
83MP0002736_abnormal_nociception_after1.02969845
84MP0004197_abnormal_fetal_growth/weight/1.01392072
85MP0001835_abnormal_antigen_presentation1.01361587
86MP0002095_abnormal_skin_pigmentation1.00700893
87MP0002163_abnormal_gland_morphology1.00453402
88MP0003755_abnormal_palate_morphology1.00116773
89MP0000465_gastrointestinal_hemorrhage0.99926070
90MP0002102_abnormal_ear_morphology0.99719349
91* MP0002085_abnormal_embryonic_tissue0.99582725
92MP0004808_abnormal_hematopoietic_stem0.97485590
93MP0003718_maternal_effect0.97435254
94* MP0002019_abnormal_tumor_incidence0.96245075
95MP0001119_abnormal_female_reproductive0.96013783
96MP0000579_abnormal_nail_morphology0.95316550
97MP0005391_vision/eye_phenotype0.94525586
98MP0003698_abnormal_male_reproductive0.92841119
99MP0001697_abnormal_embryo_size0.91719814
100MP0002088_abnormal_embryonic_growth/wei0.91614189
101MP0001177_atelectasis0.91280944
102MP0003959_abnormal_lean_body0.91250563
103MP0002452_abnormal_antigen_presenting0.91082064
104MP0001764_abnormal_homeostasis0.90569032
105MP0003984_embryonic_growth_retardation0.90349278
106MP0000631_abnormal_neuroendocrine_gland0.89956251
107MP0000358_abnormal_cell_content/0.89898532
108MP0003890_abnormal_embryonic-extraembry0.89634142
109MP0003186_abnormal_redox_activity0.86645461
110MP0000685_abnormal_immune_system0.85341363
111MP0004924_abnormal_behavior0.84146036
112MP0005386_behavior/neurological_phenoty0.84146036
113MP0005187_abnormal_penis_morphology0.83207479
114* MP0002080_prenatal_lethality0.80943716
115MP0003724_increased_susceptibility_to0.80516094
116MP0005395_other_phenotype0.80470688
117MP0003221_abnormal_cardiomyocyte_apopto0.79493508
118MP0004133_heterotaxia0.78617121
119MP0003656_abnormal_erythrocyte_physiolo0.78176878
120MP0005025_abnormal_response_to0.77845246
121MP0000383_abnormal_hair_follicle0.77630986
122MP0005647_abnormal_sex_gland0.77458082
123MP0002938_white_spotting0.77457394
124MP0002837_dystrophic_cardiac_calcinosis0.77044777
125MP0000372_irregular_coat_pigmentation0.76861743
126MP0009672_abnormal_birth_weight0.76323520
127MP0002876_abnormal_thyroid_physiology0.75756702
128MP0005379_endocrine/exocrine_gland_phen0.75318063
129MP0003646_muscle_fatigue0.75271988
130MP0002090_abnormal_vision0.73637644
131MP0005464_abnormal_platelet_physiology0.73469837
132MP0001485_abnormal_pinna_reflex0.72725688
133MP0009379_abnormal_foot_pigmentation0.71446577
134MP0002638_abnormal_pupillary_reflex0.71014574
135MP0002697_abnormal_eye_size0.70837968
136MP0002751_abnormal_autonomic_nervous0.70760405
137MP0008789_abnormal_olfactory_epithelium0.70650995
138MP0002148_abnormal_hypersensitivity_rea0.70329760
139MP0010678_abnormal_skin_adnexa0.70018286
140MP0003861_abnormal_nervous_system0.68524291
141MP0005376_homeostasis/metabolism_phenot0.67986299
142MP0005389_reproductive_system_phenotype0.66187962
143MP0008995_early_reproductive_senescence0.65941815
144MP0003935_abnormal_craniofacial_develop0.65319563
145MP0002111_abnormal_tail_morphology0.64891033
146MP0002086_abnormal_extraembryonic_tissu0.64746904
147MP0005646_abnormal_pituitary_gland0.64531112
148MP0005384_cellular_phenotype0.62358316
149MP0000537_abnormal_urethra_morphology0.61806823
150MP0000778_abnormal_nervous_system0.60629655
151MP0003943_abnormal_hepatobiliary_system0.59788036
152MP0002419_abnormal_innate_immunity0.59429939
153MP0002282_abnormal_trachea_morphology0.59199565
154MP0000015_abnormal_ear_pigmentation0.58633390
155MP0005380_embryogenesis_phenotype0.58020466
156MP0001672_abnormal_embryogenesis/_devel0.58020466
157MP0002160_abnormal_reproductive_system0.57511315
158MP0002064_seizures0.57114265
159MP0005409_darkened_coat_color0.56775175
160MP0003172_abnormal_lysosome_physiology0.56092501
161MP0002272_abnormal_nervous_system0.55901611

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolysis (HP:0004366)4.62733412
2Increased serum pyruvate (HP:0003542)4.62733412
3Acute necrotizing encephalopathy (HP:0006965)4.19275140
4Abnormal mitochondria in muscle tissue (HP:0008316)3.95853634
5Birth length less than 3rd percentile (HP:0003561)3.74061535
6Mitochondrial inheritance (HP:0001427)3.71172046
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57974690
8Increased CSF lactate (HP:0002490)3.53914979
9Progressive macrocephaly (HP:0004481)3.52766642
10Hepatocellular necrosis (HP:0001404)3.50537400
11Chromsome breakage (HP:0040012)3.43191598
12Aplastic anemia (HP:0001915)3.42682392
13Increased hepatocellular lipid droplets (HP:0006565)3.29810283
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.19569142
15Decreased activity of mitochondrial respiratory chain (HP:0008972)3.18526355
16Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.18526355
17Acute encephalopathy (HP:0006846)3.16050171
18Meckel diverticulum (HP:0002245)3.07993877
19Abnormal hair whorl (HP:0010721)3.01411506
20Pancreatic cysts (HP:0001737)2.98922872
21Pancreatic fibrosis (HP:0100732)2.98259216
22Increased serum lactate (HP:0002151)2.96719415
23Abnormality of the ileum (HP:0001549)2.96563728
24Lipid accumulation in hepatocytes (HP:0006561)2.88704833
25Abnormality of the heme biosynthetic pathway (HP:0010472)2.87147264
26Abnormality of the labia minora (HP:0012880)2.83509498
27Abnormality of the preputium (HP:0100587)2.81356664
28Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.79113132
29Reticulocytopenia (HP:0001896)2.75415301
30Hepatic necrosis (HP:0002605)2.74896537
31Rhabdomyosarcoma (HP:0002859)2.71329444
323-Methylglutaconic aciduria (HP:0003535)2.69444641
33Glioma (HP:0009733)2.69054432
34True hermaphroditism (HP:0010459)2.67480641
35Abnormality of midbrain morphology (HP:0002418)2.66573288
36Molar tooth sign on MRI (HP:0002419)2.66573288
37Cerebral hypomyelination (HP:0006808)2.62877060
38Postnatal microcephaly (HP:0005484)2.61828155
39Abnormal lung lobation (HP:0002101)2.60460021
40Lactic acidosis (HP:0003128)2.56989025
41Abnormal number of erythroid precursors (HP:0012131)2.55978164
42Sloping forehead (HP:0000340)2.55641208
43Abnormality of cells of the erythroid lineage (HP:0012130)2.54889575
44Abnormality of alanine metabolism (HP:0010916)2.54516880
45Hyperalaninemia (HP:0003348)2.54516880
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.54516880
47Duodenal stenosis (HP:0100867)2.53959757
48Small intestinal stenosis (HP:0012848)2.53959757
49Nephronophthisis (HP:0000090)2.51970473
50Progressive inability to walk (HP:0002505)2.48980058
51Ependymoma (HP:0002888)2.48431952
52Severe combined immunodeficiency (HP:0004430)2.47657775
53Hypoplasia of the pons (HP:0012110)2.42798476
54Renal Fanconi syndrome (HP:0001994)2.41919773
55Hypoplasia of the capital femoral epiphysis (HP:0003090)2.40132802
56IgM deficiency (HP:0002850)2.39994090
57Leukodystrophy (HP:0002415)2.39411283
58Poor head control (HP:0002421)2.37998365
59Degeneration of anterior horn cells (HP:0002398)2.37720690
60Abnormality of the anterior horn cell (HP:0006802)2.37720690
61Abnormality of the duodenum (HP:0002246)2.35118182
62Hypothermia (HP:0002045)2.34869906
63Astrocytoma (HP:0009592)2.34481920
64Abnormality of the astrocytes (HP:0100707)2.34481920
65Neuroendocrine neoplasm (HP:0100634)2.33492021
66Abnormality of the renal medulla (HP:0100957)2.32960056
67Abnormality of B cell number (HP:0010975)2.31215446
68B lymphocytopenia (HP:0010976)2.31215446
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.31167226
70Microvesicular hepatic steatosis (HP:0001414)2.29689519
71Type I transferrin isoform profile (HP:0003642)2.29325060
72Exercise intolerance (HP:0003546)2.25155208
73Ectopic kidney (HP:0000086)2.23900696
74Papilledema (HP:0001085)2.21903206
75Type 2 muscle fiber atrophy (HP:0003554)2.20438723
76Clubbing of toes (HP:0100760)2.18641618
77Abnormality of the renal cortex (HP:0011035)2.17957358
78Respiratory failure (HP:0002878)2.17797890
79Cerebral edema (HP:0002181)2.17107691
80Abnormality of methionine metabolism (HP:0010901)2.16208125
81Gonadotropin excess (HP:0000837)2.15340258
82Agnosia (HP:0010524)2.14110612
83Exertional dyspnea (HP:0002875)2.12687902
84Nephroblastoma (Wilms tumor) (HP:0002667)2.12595225
85Aplasia/Hypoplasia of the thymus (HP:0010515)2.11629965
86Thyroiditis (HP:0100646)2.10483137
87Pallor (HP:0000980)2.10090475
88Respiratory difficulties (HP:0002880)2.08613794
89Autoamputation (HP:0001218)2.08188312
90Volvulus (HP:0002580)2.08092411
91T lymphocytopenia (HP:0005403)2.06406131
92Oral leukoplakia (HP:0002745)2.05946600
93Combined immunodeficiency (HP:0005387)2.05496636
94Increased intramyocellular lipid droplets (HP:0012240)2.04818561
95Embryonal renal neoplasm (HP:0011794)2.04781858
96Pancytopenia (HP:0001876)2.04427861
97Macrocytic anemia (HP:0001972)2.04276993
98Hypoplasia of the thymus (HP:0000778)2.04117065
99Stenosis of the external auditory canal (HP:0000402)2.04060921
100Intestinal atresia (HP:0011100)2.03336262
101Poor suck (HP:0002033)2.00979823
102Abnormality of T cell number (HP:0011839)1.99991986
103Dandy-Walker malformation (HP:0001305)1.99971813
104Muscle fiber atrophy (HP:0100295)1.99276419
105Lymphoma (HP:0002665)1.99209498
106Abnormal number of incisors (HP:0011064)1.99085468
107Small hand (HP:0200055)1.95861227
108Pancreatic islet-cell hyperplasia (HP:0004510)1.95345549
109Thrombocytosis (HP:0001894)1.94178760
110IgG deficiency (HP:0004315)1.94145207
111Abnormality of the carotid arteries (HP:0005344)1.91538368
112Absent epiphyses (HP:0010577)1.91093401
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91093401
114Oligodactyly (hands) (HP:0001180)1.91007026
115Aqueductal stenosis (HP:0002410)1.90676052
116Protruding tongue (HP:0010808)1.89974129
117CNS hypomyelination (HP:0003429)1.89922635
118Abnormality of homocysteine metabolism (HP:0010919)1.89797827
119Homocystinuria (HP:0002156)1.89797827
120Bifid tongue (HP:0010297)1.89678792
121Bile duct proliferation (HP:0001408)1.89291028
122Abnormal biliary tract physiology (HP:0012439)1.89291028
123Myelodysplasia (HP:0002863)1.88731718
124Renal cortical cysts (HP:0000803)1.86571491
125Aplasia/Hypoplasia of the tongue (HP:0010295)1.86277372
126Methylmalonic acidemia (HP:0002912)1.86191806
127Medial flaring of the eyebrow (HP:0010747)1.85142326
128Absent radius (HP:0003974)1.84525079
129Postaxial foot polydactyly (HP:0001830)1.83701301
130Abnormal protein glycosylation (HP:0012346)1.83554644
131Abnormal glycosylation (HP:0012345)1.83554644
132Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83554644
133Abnormal protein N-linked glycosylation (HP:0012347)1.83554644
134Neoplasm of striated muscle (HP:0009728)1.83353220
135Biliary tract neoplasm (HP:0100574)1.83004216
136Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82636788
137Preaxial hand polydactyly (HP:0001177)1.82589372
138Ragged-red muscle fibers (HP:0003200)1.81388613
139Abnormality of eosinophils (HP:0001879)1.80830242
140CNS demyelination (HP:0007305)1.80784676
141Pheochromocytoma (HP:0002666)1.80706703
142Abnormality of chromosome stability (HP:0003220)1.80211566
143Failure to thrive in infancy (HP:0001531)1.79780359
144Triphalangeal thumb (HP:0001199)1.79096408
145Medulloblastoma (HP:0002885)1.77977468
146Neoplasm of the colon (HP:0100273)1.77927394
147Fair hair (HP:0002286)1.77834178
148Lissencephaly (HP:0001339)1.76509206
149Hypobetalipoproteinemia (HP:0003563)1.75917226
150Aplasia involving forearm bones (HP:0009822)1.75794792
151Absent forearm bone (HP:0003953)1.75794792
152Panhypogammaglobulinemia (HP:0003139)1.75513186
153Chronic hepatic failure (HP:0100626)1.75512193
154Type II lissencephaly (HP:0007260)1.74973123
155Inability to walk (HP:0002540)1.74608196
156Optic disc pallor (HP:0000543)1.74594798
157Bone marrow hypocellularity (HP:0005528)1.72656214
158Aplasia/Hypoplasia of the sternum (HP:0006714)1.72477262
159Supernumerary spleens (HP:0009799)1.71237512
160Colon cancer (HP:0003003)1.70045988
161Neoplasm of the adrenal cortex (HP:0100641)1.69784715
162Gaze-evoked nystagmus (HP:0000640)1.68417553
163Patellar aplasia (HP:0006443)1.67626828
164Abnormality of the pons (HP:0007361)1.67521816
165Breast carcinoma (HP:0003002)1.67178258
166Delayed gross motor development (HP:0002194)1.67155638
167Abnormality of DNA repair (HP:0003254)1.67090986
168Anencephaly (HP:0002323)1.65883525
169Cerebellar dysplasia (HP:0007033)1.65747928
170Neoplasm of the oral cavity (HP:0100649)1.65288704
171Oculomotor apraxia (HP:0000657)1.64868017
172Congenital, generalized hypertrichosis (HP:0004540)1.64725108
173Absent thumb (HP:0009777)1.64001862
174Sclerocornea (HP:0000647)1.62566185
175Astigmatism (HP:0000483)1.61851664
176Horseshoe kidney (HP:0000085)1.60421978
177Hyperventilation (HP:0002883)1.60389339
178Cupped ear (HP:0000378)1.59209721
179Abnormality of serum amino acid levels (HP:0003112)1.57960695
180Megaloblastic anemia (HP:0001889)1.56630131
181Abolished electroretinogram (ERG) (HP:0000550)1.55751733
182Aplasia/Hypoplasia of the patella (HP:0006498)1.55701637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TSSK64.05904053
2BUB13.79175415
3MAP3K123.36695066
4SIK33.24323325
5WEE13.05043899
6STK162.97824155
7SRPK12.74612337
8FRK2.72725379
9EIF2AK12.68229870
10EIF2AK32.62783585
11CDC72.59998205
12NUAK12.27471608
13BCR2.26878327
14MKNK12.24918055
15TRIM282.14050032
16ZAK2.11505431
17VRK12.09798255
18MST41.95076398
19CCNB11.87300956
20LATS11.84933879
21BRSK21.79341889
22CDK191.75721765
23PNCK1.74856344
24PLK31.53560673
25NME11.51704689
26TXK1.48822819
27PASK1.46890315
28PDK21.44522266
29STK38L1.43221402
30NME21.37757004
31CDK81.34208099
32STK31.30624937
33CSNK1G31.27047834
34MKNK21.26392339
35TNIK1.26134766
36BRSK11.23819284
37MAPKAPK51.20291092
38MAP4K11.19394694
39TAF11.17965759
40ATR1.12557754
41NEK11.09774106
42STK391.06217684
43TGFBR11.02089360
44TEC1.01561863
45TLK11.01335406
46KSR11.00482834
47OXSR11.00156805
48BMPR1B0.99388977
49MAP2K70.96399123
50KIT0.93552451
51ITK0.92699595
52FGFR20.92616215
53PBK0.91279254
54DYRK30.90933204
55MAP3K40.90908169
56PLK10.89873914
57CASK0.84015561
58AURKB0.80068402
59SYK0.79715284
60ACVR1B0.79611806
61CSF1R0.78789465
62PLK40.75525114
63PAK40.75338572
64NLK0.75150630
65AURKA0.74975702
66VRK20.74351331
67YES10.73560121
68ERBB40.73039909
69RPS6KB20.71139954
70DYRK20.70177234
71BTK0.69697547
72MINK10.68759912
73SCYL20.68696577
74AKT30.68464381
75TESK20.68444912
76CSNK1G20.67714639
77IRAK10.67450626
78MAP4K20.66226994
79CDK70.66141863
80GRK10.65706615
81ERBB30.65046983
82DAPK10.64412873
83IRAK20.64032175
84CSNK1A1L0.63956246
85ADRBK20.63510415
86CSNK2A20.61723988
87CHEK10.60245164
88CLK10.59887630
89BRD40.59585951
90EIF2AK20.58968311
91CSNK1G10.57967619
92CDK30.57495142
93INSRR0.56491369
94PLK20.56201961
95NEK20.55764776
96LYN0.53851310
97CSNK2A10.52885130
98MARK30.52245414
99UHMK10.52022135
100STK100.51710659
101BMPR20.50785267
102CDK180.48126414
103LIMK10.46489745
104LCK0.45836345
105CSNK1E0.44126603
106CAMK1G0.43891390
107IRAK40.43205240
108FGFR10.42761999
109PAK30.42463657
110CHEK20.41219135
111STK40.40338827
112JAK30.39672586
113FLT30.39132413
114RPS6KA40.38101145
115STK240.37676495
116MAPK130.37565323
117WNK30.37363767
118MAP3K140.37354641
119TTK0.36935263
120MYLK0.36321337
121KDR0.36085438
122ALK0.36005358
123CDK140.35939825
124CDK10.35831659
125PRKCG0.35520700
126FES0.35509407
127PIM10.35489348
128CAMK1D0.35398245
129MELK0.33709596
130ATM0.33574194
131GRK60.33174555
132CDK20.33124619
133PRKDC0.32381862
134ZAP700.31768968
135NTRK20.31475739
136CDK150.30785866
137WNK40.27021462
138NEK60.23440737
139CSNK1D0.21775717

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.65215198
2DNA replication_Homo sapiens_hsa030304.12722888
3Mismatch repair_Homo sapiens_hsa034303.29620225
4Spliceosome_Homo sapiens_hsa030403.29292110
5Ribosome_Homo sapiens_hsa030103.27140790
6RNA polymerase_Homo sapiens_hsa030203.08952113
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97307410
8Protein export_Homo sapiens_hsa030602.72683053
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.63166324
10Non-homologous end-joining_Homo sapiens_hsa034502.56858686
11Nucleotide excision repair_Homo sapiens_hsa034202.51849396
12Pyrimidine metabolism_Homo sapiens_hsa002402.51836236
13Oxidative phosphorylation_Homo sapiens_hsa001902.51791304
14RNA transport_Homo sapiens_hsa030132.33585255
15Parkinsons disease_Homo sapiens_hsa050122.21348388
16Base excision repair_Homo sapiens_hsa034102.17065386
17Homologous recombination_Homo sapiens_hsa034402.07924249
18Cell cycle_Homo sapiens_hsa041101.99693222
19Propanoate metabolism_Homo sapiens_hsa006401.90457862
20One carbon pool by folate_Homo sapiens_hsa006701.86614332
21RNA degradation_Homo sapiens_hsa030181.84791045
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.69583301
23Basal transcription factors_Homo sapiens_hsa030221.61165978
24Huntingtons disease_Homo sapiens_hsa050161.46946271
25Fanconi anemia pathway_Homo sapiens_hsa034601.39684034
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.39185047
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39096534
28Purine metabolism_Homo sapiens_hsa002301.34589634
29Alzheimers disease_Homo sapiens_hsa050101.32825439
30Primary immunodeficiency_Homo sapiens_hsa053401.31428601
31Epstein-Barr virus infection_Homo sapiens_hsa051691.28339671
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.24731222
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24193639
34Phototransduction_Homo sapiens_hsa047441.12373812
35Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.11266736
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08478026
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07674479
38mRNA surveillance pathway_Homo sapiens_hsa030151.04718685
39Butanoate metabolism_Homo sapiens_hsa006501.03830841
40Antigen processing and presentation_Homo sapiens_hsa046121.02592423
41Collecting duct acid secretion_Homo sapiens_hsa049661.01473655
42Vibrio cholerae infection_Homo sapiens_hsa051100.96789828
43Type I diabetes mellitus_Homo sapiens_hsa049400.95366343
44Systemic lupus erythematosus_Homo sapiens_hsa053220.93042874
45Fatty acid elongation_Homo sapiens_hsa000620.92739459
46TGF-beta signaling pathway_Homo sapiens_hsa043500.91147580
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.90064945
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.83364563
49Allograft rejection_Homo sapiens_hsa053300.80081002
50Legionellosis_Homo sapiens_hsa051340.77284972
51Lysine degradation_Homo sapiens_hsa003100.75479628
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.74255210
53Phagosome_Homo sapiens_hsa041450.72257238
54Circadian rhythm_Homo sapiens_hsa047100.69854575
55Hedgehog signaling pathway_Homo sapiens_hsa043400.69153052
56Nitrogen metabolism_Homo sapiens_hsa009100.68868270
57N-Glycan biosynthesis_Homo sapiens_hsa005100.68832131
58Viral carcinogenesis_Homo sapiens_hsa052030.67826184
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66938840
60Shigellosis_Homo sapiens_hsa051310.66455557
61Hippo signaling pathway_Homo sapiens_hsa043900.64192894
62p53 signaling pathway_Homo sapiens_hsa041150.61510290
63Oocyte meiosis_Homo sapiens_hsa041140.59487762
64Biosynthesis of amino acids_Homo sapiens_hsa012300.58250601
65Pyruvate metabolism_Homo sapiens_hsa006200.57730195
66Rheumatoid arthritis_Homo sapiens_hsa053230.56332957
67Herpes simplex infection_Homo sapiens_hsa051680.56304577
68Selenocompound metabolism_Homo sapiens_hsa004500.56258718
69Tryptophan metabolism_Homo sapiens_hsa003800.55593161
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53820595
71Wnt signaling pathway_Homo sapiens_hsa043100.53068671
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.51670036
73Vitamin B6 metabolism_Homo sapiens_hsa007500.51339150
74Measles_Homo sapiens_hsa051620.50735580
75Taste transduction_Homo sapiens_hsa047420.50541761
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50529030
77Pentose phosphate pathway_Homo sapiens_hsa000300.49718922
78Alcoholism_Homo sapiens_hsa050340.49003347
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48689754
80Graft-versus-host disease_Homo sapiens_hsa053320.48471325
81Olfactory transduction_Homo sapiens_hsa047400.48367093
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48096413
83Metabolic pathways_Homo sapiens_hsa011000.47448842
84Basal cell carcinoma_Homo sapiens_hsa052170.46999505
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46764444
86Autoimmune thyroid disease_Homo sapiens_hsa053200.45641023
87Hematopoietic cell lineage_Homo sapiens_hsa046400.45191709
88Carbon metabolism_Homo sapiens_hsa012000.43818268
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42984947
90Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.41015948
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39662398
92T cell receptor signaling pathway_Homo sapiens_hsa046600.37931242
93Caffeine metabolism_Homo sapiens_hsa002320.37558643
94Steroid biosynthesis_Homo sapiens_hsa001000.37506276
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36691183
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35465196
97Linoleic acid metabolism_Homo sapiens_hsa005910.34769143
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.34709982
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.34398729
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33432170
101Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31509440
102Hepatitis B_Homo sapiens_hsa051610.30499653
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.30383196
104Peroxisome_Homo sapiens_hsa041460.29484888
105Asthma_Homo sapiens_hsa053100.29245667
106Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.29111488
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29066109
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.28855207
109Folate biosynthesis_Homo sapiens_hsa007900.27340750
110Synaptic vesicle cycle_Homo sapiens_hsa047210.26136424
111Nicotine addiction_Homo sapiens_hsa050330.25766887
112MicroRNAs in cancer_Homo sapiens_hsa052060.25230661
113Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24762022
114NF-kappa B signaling pathway_Homo sapiens_hsa040640.24326372
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.24272653
116Colorectal cancer_Homo sapiens_hsa052100.23578206
117Renin-angiotensin system_Homo sapiens_hsa046140.23385800
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23133168
119beta-Alanine metabolism_Homo sapiens_hsa004100.19748760
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19592801
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.19127396
122Steroid hormone biosynthesis_Homo sapiens_hsa001400.18192324
123Glutathione metabolism_Homo sapiens_hsa004800.18181618
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17519718
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.16647155
126Mineral absorption_Homo sapiens_hsa049780.16254415
127Fatty acid metabolism_Homo sapiens_hsa012120.15976410
128HTLV-I infection_Homo sapiens_hsa051660.14847536
129Retinol metabolism_Homo sapiens_hsa008300.14610818
130Ether lipid metabolism_Homo sapiens_hsa005650.14366143
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.13659611
132Adherens junction_Homo sapiens_hsa045200.12588298
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.12095492
134Regulation of autophagy_Homo sapiens_hsa041400.11484867
135Fatty acid biosynthesis_Homo sapiens_hsa000610.11205873
136Prostate cancer_Homo sapiens_hsa052150.09462276
137Apoptosis_Homo sapiens_hsa042100.09100202
138Sulfur metabolism_Homo sapiens_hsa009200.08959229
139Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08670551
140Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.08180312
141Tight junction_Homo sapiens_hsa045300.07996035
142Amphetamine addiction_Homo sapiens_hsa050310.07631784

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