CHMP4C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CHMP4C belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bundle of His cell to Purkinje myocyte communication (GO:0086069)8.05265647
2intestinal epithelial cell development (GO:0060576)7.48471639
3intestinal absorption (GO:0050892)7.05100660
4desmosome organization (GO:0002934)6.97012639
5hemidesmosome assembly (GO:0031581)6.21021887
6intestinal cholesterol absorption (GO:0030299)6.10296501
7regulation of water loss via skin (GO:0033561)5.11946564
8negative regulation of keratinocyte proliferation (GO:0010839)4.84881773
9cellular response to vitamin D (GO:0071305)4.51521477
10establishment of skin barrier (GO:0061436)4.50938607
11UDP-N-acetylglucosamine metabolic process (GO:0006047)4.39713233
12angiotensin maturation (GO:0002003)4.33195021
13interferon-gamma secretion (GO:0072643)4.32898649
14trophectodermal cell differentiation (GO:0001829)4.17344754
15columnar/cuboidal epithelial cell development (GO:0002066)4.16923903
16ventricular cardiac muscle cell action potential (GO:0086005)4.05593540
17regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.87936775
18auditory receptor cell differentiation (GO:0042491)3.81341310
19epithelial cell-cell adhesion (GO:0090136)3.80353137
20multicellular organismal water homeostasis (GO:0050891)3.78541094
21behavioral response to nicotine (GO:0035095)3.73609006
22glandular epithelial cell differentiation (GO:0002067)3.61210443
23regulation of cardioblast differentiation (GO:0051890)3.56522883
24L-fucose catabolic process (GO:0042355)3.53599190
25fucose catabolic process (GO:0019317)3.53599190
26L-fucose metabolic process (GO:0042354)3.53599190
27purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.45871055
283-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.45871055
29regulation of bile acid biosynthetic process (GO:0070857)3.39939163
30cellular response to vitamin (GO:0071295)3.39005225
31keratinocyte proliferation (GO:0043616)3.37348626
32digestive system process (GO:0022600)3.35972495
33tight junction assembly (GO:0070830)3.35546853
34vitamin A metabolic process (GO:0006776)3.33428778
35cellular ketone body metabolic process (GO:0046950)3.33116193
36maintenance of gastrointestinal epithelium (GO:0030277)3.31559388
37regulation of apoptotic process involved in morphogenesis (GO:1902337)3.28264111
38notochord development (GO:0030903)3.27412179
39mannosylation (GO:0097502)3.26204278
40preassembly of GPI anchor in ER membrane (GO:0016254)3.25708243
41branching involved in mammary gland duct morphogenesis (GO:0060444)3.17748082
42sulfate transmembrane transport (GO:1902358)3.16749465
43endocrine pancreas development (GO:0031018)3.14499332
44sphingoid metabolic process (GO:0046519)3.11346815
45cellular glucuronidation (GO:0052695)3.10954373
46hormone catabolic process (GO:0042447)3.09734203
47uronic acid metabolic process (GO:0006063)3.09571490
48glucuronate metabolic process (GO:0019585)3.09571490
49phosphatidylserine acyl-chain remodeling (GO:0036150)3.08796476
50flavonoid metabolic process (GO:0009812)3.07857827
51anterior/posterior axis specification, embryo (GO:0008595)3.04665011
52water homeostasis (GO:0030104)3.02639026
53water-soluble vitamin biosynthetic process (GO:0042364)3.02412006
54phosphatidylinositol acyl-chain remodeling (GO:0036149)3.01302158
55digestion (GO:0007586)2.98371536
56phenylpropanoid metabolic process (GO:0009698)2.97988959
57atrioventricular valve morphogenesis (GO:0003181)2.96187804
58positive regulation of epidermal cell differentiation (GO:0045606)2.93573745
59ketone body metabolic process (GO:1902224)2.90569920
60regulation of keratinocyte proliferation (GO:0010837)2.90449845
61ectoderm development (GO:0007398)2.90347228
62L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.89807761
63positive regulation of Cdc42 GTPase activity (GO:0043089)2.89147353
64regulation of gene silencing by RNA (GO:0060966)2.89054670
65regulation of posttranscriptional gene silencing (GO:0060147)2.89054670
66regulation of gene silencing by miRNA (GO:0060964)2.89054670
67epithelial structure maintenance (GO:0010669)2.88081851
68cell communication involved in cardiac conduction (GO:0086065)2.86995633
69negative regulation of cell fate commitment (GO:0010454)2.86841642
70nucleotide-sugar biosynthetic process (GO:0009226)2.86836889
71virion attachment to host cell (GO:0019062)2.85737493
72adhesion of symbiont to host cell (GO:0044650)2.85737493
73arginine metabolic process (GO:0006525)2.83397157
74DNA deamination (GO:0045006)2.83069952
75regulation of hippo signaling (GO:0035330)2.82045311
76heme transport (GO:0015886)2.81898793
77actin filament depolymerization (GO:0030042)2.80332883
78sulfur compound transport (GO:0072348)2.80305759
79positive regulation of epidermis development (GO:0045684)2.80287718
80regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.79664271
81response to hepatocyte growth factor (GO:0035728)2.78069897
82cellular response to hepatocyte growth factor stimulus (GO:0035729)2.78069897
83L-methionine salvage (GO:0071267)2.77960003
84L-methionine biosynthetic process (GO:0071265)2.77960003
85amino acid salvage (GO:0043102)2.77960003
86regulation of chemokine secretion (GO:0090196)2.77857863
87keratinization (GO:0031424)2.76932775
88exogenous drug catabolic process (GO:0042738)2.76682627
89negative regulation of cell fate specification (GO:0009996)2.76212011
90detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.75983914
91erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75955196
92L-phenylalanine metabolic process (GO:0006558)2.75955196
93phenol-containing compound catabolic process (GO:0019336)2.75845100
94branching involved in labyrinthine layer morphogenesis (GO:0060670)2.75697027
95indolalkylamine metabolic process (GO:0006586)2.74976731
96peptide catabolic process (GO:0043171)2.74654612
97inner ear receptor cell differentiation (GO:0060113)2.74399254
98cornea development in camera-type eye (GO:0061303)2.74233385
99sulfate transport (GO:0008272)2.74139220
100regulation of glucokinase activity (GO:0033131)2.73872248
101regulation of hexokinase activity (GO:1903299)2.73872248
102negative regulation of T cell differentiation in thymus (GO:0033085)2.72904291
103keratinocyte differentiation (GO:0030216)2.71533677
104cardiac right ventricle morphogenesis (GO:0003215)2.70613253
105nephron tubule morphogenesis (GO:0072078)2.70044883
106nephron epithelium morphogenesis (GO:0072088)2.70044883
107kidney morphogenesis (GO:0060993)2.69961935
108peptide hormone processing (GO:0016486)2.69123958
109piRNA metabolic process (GO:0034587)2.68288885
110quinone metabolic process (GO:1901661)2.68029515
111drug catabolic process (GO:0042737)2.66711021
112response to pheromone (GO:0019236)2.66360842
113regulation of cell fate specification (GO:0042659)2.66070250
114autophagic vacuole fusion (GO:0000046)2.65859550
115retinal metabolic process (GO:0042574)2.65267499
116diol metabolic process (GO:0034311)2.64834112
117hepatocyte apoptotic process (GO:0097284)2.63573097
118dorsal/ventral axis specification (GO:0009950)2.63409669
119calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.63370216
120positive regulation of prostaglandin secretion (GO:0032308)2.63167695
121cell-substrate junction assembly (GO:0007044)2.60276054
122biotin metabolic process (GO:0006768)2.59692839
123terpenoid biosynthetic process (GO:0016114)2.58568234
124vitamin transmembrane transport (GO:0035461)2.56490321
125epidermal cell differentiation (GO:0009913)2.56222700
126S-adenosylmethionine metabolic process (GO:0046500)2.55849987
127negative regulation of epidermal cell differentiation (GO:0045605)2.55074259
128sphingosine metabolic process (GO:0006670)2.54965276
129maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.54540958
130regulation of heart rate by cardiac conduction (GO:0086091)2.53282517
131Golgi transport vesicle coating (GO:0048200)2.53127430
132COPI coating of Golgi vesicle (GO:0048205)2.53127430
133magnesium ion transport (GO:0015693)2.51575823
134epoxygenase P450 pathway (GO:0019373)2.51362214
135sarcomere organization (GO:0045214)2.50545529
136indole-containing compound catabolic process (GO:0042436)2.50228126
137indolalkylamine catabolic process (GO:0046218)2.50228126
138tryptophan catabolic process (GO:0006569)2.50228126
139positive regulation of p38MAPK cascade (GO:1900745)2.50024875
140GPI anchor metabolic process (GO:0006505)2.49487935
141branched-chain amino acid catabolic process (GO:0009083)2.49328569
142GPI anchor biosynthetic process (GO:0006506)2.49247138
143respiratory chain complex IV assembly (GO:0008535)2.48011580
144aromatic amino acid family catabolic process (GO:0009074)2.47180005
145glutathione derivative biosynthetic process (GO:1901687)2.47013915
146glutathione derivative metabolic process (GO:1901685)2.47013915
147vitamin transport (GO:0051180)2.46746698
148cardiac conduction (GO:0061337)2.46499761
149signal transduction involved in regulation of gene expression (GO:0023019)2.46478615
150phospholipid scrambling (GO:0017121)2.46029734
151keratinocyte development (GO:0003334)2.45689603
152drug metabolic process (GO:0017144)2.45381640
153auditory receptor cell stereocilium organization (GO:0060088)2.44008727
154quinone biosynthetic process (GO:1901663)2.43928278
155gap junction assembly (GO:0016264)2.43821565
156kynurenine metabolic process (GO:0070189)2.43804088
157erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.43750868
158L-phenylalanine catabolic process (GO:0006559)2.43750868
159phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.43358949
160establishment of apical/basal cell polarity (GO:0035089)2.43133012
161pseudouridine synthesis (GO:0001522)2.43086754
162COPII vesicle coating (GO:0048208)2.43045471
163thyroid hormone metabolic process (GO:0042403)2.42881308
164nucleotide transmembrane transport (GO:1901679)2.41133488
165diterpenoid biosynthetic process (GO:0016102)2.39573822
166regulation of integrin activation (GO:0033623)2.39451438
167positive regulation of establishment of protein localization to plasma membrane (GO:0090004)2.39268135
168drug transmembrane transport (GO:0006855)2.38668542
169renal absorption (GO:0070293)2.36424876
170modified amino acid transport (GO:0072337)2.36361213
171GDP-mannose metabolic process (GO:0019673)2.36338072
172proline biosynthetic process (GO:0006561)2.36221901
173transepithelial transport (GO:0070633)2.35332395
174transcytosis (GO:0045056)2.34941521
175determination of adult lifespan (GO:0008340)2.34020048
176intermediate filament organization (GO:0045109)2.33737213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.50997589
2ZNF274_21170338_ChIP-Seq_K562_Hela3.12066467
3VDR_22108803_ChIP-Seq_LS180_Human3.03512988
4SOX2_27498859_Chip-Seq_STOMACH_Mouse3.01532088
5ESR1_21235772_ChIP-Seq_MCF-7_Human2.98150236
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.97978235
7CDX2_20551321_ChIP-Seq_CACO-2_Human2.86502725
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.61710742
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.61710742
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.61710742
11GATA6_25053715_ChIP-Seq_YYC3_Human2.57418427
12GATA4_25053715_ChIP-Seq_YYC3_Human2.47502817
13ESR2_21235772_ChIP-Seq_MCF-7_Human2.28701930
14ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.28575904
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.23491804
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.20788494
17TCF3_18692474_ChIP-Seq_MEFs_Mouse2.20525514
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.20272114
19SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.19607500
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.16953074
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.05588502
22TP63_17297297_ChIP-ChIP_HaCaT_Human11.0420042
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.97232403
24SOX2_20726797_ChIP-Seq_SW620_Human1.95448252
25TCF3_18692474_ChIP-Seq_MESCs_Mouse1.92279042
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.91375717
27KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.90346621
28AHR_22903824_ChIP-Seq_MCF-7_Human1.88462815
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.87915234
30ER_23166858_ChIP-Seq_MCF-7_Human1.87846883
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85560141
32HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.84568631
33ZNF263_19887448_ChIP-Seq_K562_Human1.84148458
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.82648387
35SOX9_24532713_ChIP-Seq_HFSC_Mouse1.80070292
36HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.79296715
37SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79254133
38SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79254133
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.75987729
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.74166227
41* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.73495268
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.72275307
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70755580
44* AR_20517297_ChIP-Seq_VCAP_Human1.67721249
45SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.67397373
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.66166743
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.61778751
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.61778751
49HOXB7_26014856_ChIP-Seq_BT474_Human1.61656608
50RUNX1_27514584_Chip-Seq_MCF-7_Human1.61090692
51KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.60162116
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59613841
53* FOXA1_25552417_ChIP-Seq_VCAP_Human1.58990357
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.54077707
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.54017791
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53908665
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53863772
58CDX2_22108803_ChIP-Seq_LS180_Human1.53760848
59AR_21909140_ChIP-Seq_LNCAP_Human1.53466008
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.52365004
61* ATF3_27146783_Chip-Seq_COLON_Human1.50189000
62GATA3_24758297_ChIP-Seq_MCF-7_Human1.50103156
63FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.49936430
64KLF5_25053715_ChIP-Seq_YYC3_Human1.49911678
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49013010
66RACK7_27058665_Chip-Seq_MCF-7_Human1.48548849
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.43422953
68FUS_26573619_Chip-Seq_HEK293_Human1.42919343
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42788808
70KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.42566341
71RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41902748
72ELF5_23300383_ChIP-Seq_T47D_Human1.41482027
73TP53_22573176_ChIP-Seq_HFKS_Human1.39887713
74NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.39521653
75E2F7_22180533_ChIP-Seq_HELA_Human1.38228151
76EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.36426414
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.35766313
78ELK1_19687146_ChIP-ChIP_HELA_Human1.33480921
79TCF4_22108803_ChIP-Seq_LS180_Human1.33211218
80ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32320959
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.31909816
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.30439305
83* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29819704
84NANOG_18692474_ChIP-Seq_MESCs_Mouse1.28782490
85NANOG_18692474_ChIP-Seq_MEFs_Mouse1.28711899
86ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.28428670
87ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28172366
88* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26625464
89* GATA3_21878914_ChIP-Seq_MCF-7_Human1.26470486
90EWS_26573619_Chip-Seq_HEK293_Human1.25998718
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25888699
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.23810426
93CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.23762209
94CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22978301
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22660369
96SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22482848
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22407886
98NANOG_19829295_ChIP-Seq_ESCs_Human1.22190820
99SOX2_19829295_ChIP-Seq_ESCs_Human1.22190820
100FLI1_27457419_Chip-Seq_LIVER_Mouse1.21149193
101BCAT_22108803_ChIP-Seq_LS180_Human1.21093068
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20956333
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20387246
104MYC_18940864_ChIP-ChIP_HL60_Human1.20032061
105STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19633095
106AR_25329375_ChIP-Seq_VCAP_Human1.19370800
107NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18048416
108NCOR_22424771_ChIP-Seq_293T_Human1.17005795
109RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16858373
110GATA1_22025678_ChIP-Seq_K562_Human1.15093811
111NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14888901
112GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.14720570
113P300_19829295_ChIP-Seq_ESCs_Human1.12767619
114GBX2_23144817_ChIP-Seq_PC3_Human1.12556010
115CBP_20019798_ChIP-Seq_JUKART_Human1.12286110
116IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12286110
117JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11926842
118TDRD3_21172665_ChIP-Seq_MCF-7_Human1.10537391
119PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10295254
120NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.09808192
121TP63_23658742_ChIP-Seq_EP156T_Human1.09638101
122P53_21459846_ChIP-Seq_SAOS-2_Human1.09139462
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.08471188
124* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08402213
125BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08363767
126TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08233907
127FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08087460
128ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07917799
129TAF15_26573619_Chip-Seq_HEK293_Human1.07509018
130EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07164783
131* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03858579
132PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03846621
133CLOCK_20551151_ChIP-Seq_293T_Human1.03601935
134SRF_21415370_ChIP-Seq_HL-1_Mouse1.03461308
135EST1_17652178_ChIP-ChIP_JURKAT_Human1.03269419
136ETS1_20019798_ChIP-Seq_JURKAT_Human1.01553502
137TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.01109439
138ERG_20517297_ChIP-Seq_VCAP_Human1.01096214
139ERA_21632823_ChIP-Seq_H3396_Human0.99760895
140AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99686105
141LXR_22158963_ChIP-Seq_LIVER_Mouse0.99627832
142ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.99173076
143HTT_18923047_ChIP-ChIP_STHdh_Human0.97058933
144MYC_19079543_ChIP-ChIP_MESCs_Mouse0.96349830
145KDM5A_27292631_Chip-Seq_BREAST_Human0.95283558
146* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95071488
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94370949
148CHD1_26751641_Chip-Seq_LNCaP_Human0.94065696
149OCT4_18692474_ChIP-Seq_MEFs_Mouse0.91379775
150TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88955063
151* KAP1_27257070_Chip-Seq_ESCs_Mouse0.88440170
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.86488509
153POU5F1_16518401_ChIP-PET_MESCs_Mouse0.86450468
154ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86196283
155POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85617542
156PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85437415
157JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85115174
158CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.85081825
159NANOG_21062744_ChIP-ChIP_HESCs_Human0.84959341
160ELK1_22589737_ChIP-Seq_MCF10A_Human0.84785215
161ESR1_15608294_ChIP-ChIP_MCF-7_Human0.83634395
162KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.81161166
163FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80627180
164CJUN_26792858_Chip-Seq_BT549_Human0.80237079

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.57296524
2MP0004264_abnormal_extraembryonic_tissu3.82217145
3MP0003941_abnormal_skin_development3.30152855
4MP0002796_impaired_skin_barrier3.30092095
5MP0008875_abnormal_xenobiotic_pharmacok3.22093336
6MP0001666_abnormal_nutrient_absorption3.10568969
7MP0010352_gastrointestinal_tract_polyps2.69645018
8MP0004147_increased_porphyrin_level2.59918099
9MP0003283_abnormal_digestive_organ2.42280508
10MP0009780_abnormal_chondrocyte_physiolo2.33847586
11MP0002876_abnormal_thyroid_physiology2.29021982
12MP0000537_abnormal_urethra_morphology2.27635991
13MP0000462_abnormal_digestive_system2.22743384
14MP0002098_abnormal_vibrissa_morphology2.20690358
15MP0005501_abnormal_skin_physiology2.18086056
16MP0003195_calcinosis2.11742227
17MP0010678_abnormal_skin_adnexa2.09557341
18MP0005360_urolithiasis2.06837132
19MP0002254_reproductive_system_inflammat2.06590094
20MP0003878_abnormal_ear_physiology2.05474993
21MP0005377_hearing/vestibular/ear_phenot2.05474993
22MP0003566_abnormal_cell_adhesion1.95083008
23MP0003705_abnormal_hypodermis_morpholog1.93476344
24MP0009379_abnormal_foot_pigmentation1.91519874
25MP0000579_abnormal_nail_morphology1.90947019
26MP0004043_abnormal_pH_regulation1.88783080
27MP0002877_abnormal_melanocyte_morpholog1.82349806
28MP0003453_abnormal_keratinocyte_physiol1.79906164
29MP0002060_abnormal_skin_morphology1.74167520
30MP0008872_abnormal_physiological_respon1.72398696
31MP0005085_abnormal_gallbladder_physiolo1.69864950
32MP0002139_abnormal_hepatobiliary_system1.63531016
33MP0003718_maternal_effect1.62385628
34MP0006072_abnormal_retinal_apoptosis1.59877676
35MP0003300_gastrointestinal_ulcer1.59265458
36MP0003693_abnormal_embryo_hatching1.58892549
37MP0005275_abnormal_skin_tensile1.58586221
38MP0001216_abnormal_epidermal_layer1.57957955
39MP0005332_abnormal_amino_acid1.57503720
40MP0000516_abnormal_urinary_system1.52828530
41MP0005367_renal/urinary_system_phenotyp1.52828530
42MP0004019_abnormal_vitamin_homeostasis1.52798782
43MP0001849_ear_inflammation1.51741335
44MP0000467_abnormal_esophagus_morphology1.49105626
45MP0000490_abnormal_crypts_of1.47925959
46MP0000383_abnormal_hair_follicle1.47752717
47MP0001764_abnormal_homeostasis1.46669278
48MP0002009_preneoplasia1.46134593
49MP0005636_abnormal_mineral_homeostasis1.44005411
50MP0005551_abnormal_eye_electrophysiolog1.43970292
51MP0002909_abnormal_adrenal_gland1.43624543
52MP0000566_synostosis1.41950971
53MP0001873_stomach_inflammation1.41769892
54MP0003252_abnormal_bile_duct1.40258027
55MP0005408_hypopigmentation1.36407074
56MP0005646_abnormal_pituitary_gland1.35507542
57MP0010329_abnormal_lipoprotein_level1.35135092
58MP0002938_white_spotting1.34845640
59MP0000762_abnormal_tongue_morphology1.31707528
60MP0003866_abnormal_defecation1.29030190
61MP0004185_abnormal_adipocyte_glucose1.25964690
62MP0003119_abnormal_digestive_system1.25881877
63MP0000377_abnormal_hair_follicle1.24930596
64MP0000538_abnormal_urinary_bladder1.24133724
65MP0000477_abnormal_intestine_morphology1.23058759
66MP0000678_abnormal_parathyroid_gland1.19476837
67MP0008004_abnormal_stomach_pH1.18136891
68MP0004957_abnormal_blastocyst_morpholog1.15731485
69MP0005076_abnormal_cell_differentiation1.15681325
70MP0000613_abnormal_salivary_gland1.15437047
71MP0005257_abnormal_intraocular_pressure1.14487904
72MP0010386_abnormal_urinary_bladder1.11946798
73MP0009697_abnormal_copulation1.11786171
74MP0003011_delayed_dark_adaptation1.11166016
75MP0001346_abnormal_lacrimal_gland1.10396929
76MP0010155_abnormal_intestine_physiology1.10334603
77MP0004885_abnormal_endolymph1.09452826
78MP0002234_abnormal_pharynx_morphology1.08666999
79MP0003183_abnormal_peptide_metabolism1.08635544
80MP0000470_abnormal_stomach_morphology1.08611987
81MP0004947_skin_inflammation1.06137072
82MP0002163_abnormal_gland_morphology1.03358939
83MP0010030_abnormal_orbit_morphology1.03190501
84MP0010771_integument_phenotype1.02331069
85MP0008775_abnormal_heart_ventricle1.02232414
86MP0003787_abnormal_imprinting1.01719835
87MP0005381_digestive/alimentary_phenotyp1.01408670
88MP0001944_abnormal_pancreas_morphology1.00334452
89MP0002160_abnormal_reproductive_system1.00111189
90MP0005365_abnormal_bile_salt0.98896090
91MP0001485_abnormal_pinna_reflex0.98255514
92MP0008877_abnormal_DNA_methylation0.98010579
93MP0005083_abnormal_biliary_tract0.97914592
94MP0001756_abnormal_urination0.97456620
95MP0009643_abnormal_urine_homeostasis0.97144600
96MP0005220_abnormal_exocrine_pancreas0.97087948
97MP0002736_abnormal_nociception_after0.96832061
98MP0000372_irregular_coat_pigmentation0.96580366
99MP0004084_abnormal_cardiac_muscle0.95346655
100MP0009053_abnormal_anal_canal0.92354018
101MP0003890_abnormal_embryonic-extraembry0.90097424
102MP0005395_other_phenotype0.89983832
103MP0002277_abnormal_respiratory_mucosa0.89648020
104MP0000427_abnormal_hair_cycle0.89539282
105MP0001881_abnormal_mammary_gland0.88097319
106MP0005253_abnormal_eye_physiology0.86795731
107MP0002653_abnormal_ependyma_morphology0.84876553
108MP0006054_spinal_hemorrhage0.84837308
109MP0005084_abnormal_gallbladder_morpholo0.84779773
110MP0009384_cardiac_valve_regurgitation0.84618344
111MP0001919_abnormal_reproductive_system0.84328295
112MP0005379_endocrine/exocrine_gland_phen0.84194625
113MP0001663_abnormal_digestive_system0.84139145
114MP0001664_abnormal_digestion0.83535481
115MP0003806_abnormal_nucleotide_metabolis0.83514994
116MP0005448_abnormal_energy_balance0.83385777
117MP0000627_abnormal_mammary_gland0.82885121
118MP0003638_abnormal_response/metabolism_0.81819178
119MP0003045_fibrosis0.81790771
120MP0003950_abnormal_plasma_membrane0.81731728
121MP0005248_abnormal_Harderian_gland0.81618433
122MP0003136_yellow_coat_color0.81446647
123MP0002102_abnormal_ear_morphology0.81416676
124MP0002118_abnormal_lipid_homeostasis0.81105642
125MP0005645_abnormal_hypothalamus_physiol0.80139953
126MP0001191_abnormal_skin_condition0.78745853
127MP0001501_abnormal_sleep_pattern0.78524720
128MP0002086_abnormal_extraembryonic_tissu0.78513294
129MP0003868_abnormal_feces_composition0.78070953
130MP0005389_reproductive_system_phenotype0.75653451
131MP0002136_abnormal_kidney_physiology0.74296111
132MP0005023_abnormal_wound_healing0.74174638
133MP0002837_dystrophic_cardiac_calcinosis0.73042852
134MP0000631_abnormal_neuroendocrine_gland0.72436739
135MP0001672_abnormal_embryogenesis/_devel0.72189131
136MP0005380_embryogenesis_phenotype0.72189131
137MP0003567_abnormal_fetal_cardiomyocyte0.71949588
138MP0002638_abnormal_pupillary_reflex0.71872716
139MP0003953_abnormal_hormone_level0.71483199
140MP0004272_abnormal_basement_membrane0.69733833
141MP0003936_abnormal_reproductive_system0.69623407
142MP0000647_abnormal_sebaceous_gland0.69543671
143MP0005666_abnormal_adipose_tissue0.69208964
144MP0002896_abnormal_bone_mineralization0.69077143
145MP0001765_abnormal_ion_homeostasis0.68623534
146MP0004782_abnormal_surfactant_physiolog0.68154562
147MP0004133_heterotaxia0.68010332
148MP0000367_abnormal_coat/_hair0.67856631
149MP0002084_abnormal_developmental_patter0.66431320
150MP0000003_abnormal_adipose_tissue0.65614726
151MP0003315_abnormal_perineum_morphology0.64359760
152MP0002138_abnormal_hepatobiliary_system0.64250189
153MP0005330_cardiomyopathy0.63916390
154MP0003984_embryonic_growth_retardation0.63758596
155MP0002088_abnormal_embryonic_growth/wei0.63609559
156MP0003828_pulmonary_edema0.63395090
157MP0002693_abnormal_pancreas_physiology0.62371387

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)7.42502798
2Ventricular tachycardia (HP:0004756)4.37471319
3Onycholysis (HP:0001806)4.27541054
4Ileus (HP:0002595)4.01125423
5Milia (HP:0001056)3.96260329
6Woolly hair (HP:0002224)3.78899727
7Plantar hyperkeratosis (HP:0007556)3.39217543
8Pili torti (HP:0003777)3.38374461
9Fragile nails (HP:0001808)3.27759937
10Pancreatic cysts (HP:0001737)3.26069849
11Abnormal biliary tract morphology (HP:0012440)3.23025788
12Villous atrophy (HP:0011473)3.20349818
13Abnormality of small intestinal villus morphology (HP:0011472)3.20349818
14Abnormality of the renal cortex (HP:0011035)3.18388658
15Malnutrition (HP:0004395)3.15703376
16Hyperactive renin-angiotensin system (HP:0000841)3.10548119
17Atrophic scars (HP:0001075)3.01770677
18Pustule (HP:0200039)2.98783418
19Biliary tract neoplasm (HP:0100574)2.97954662
20Abdominal distention (HP:0003270)2.97503373
21Curly hair (HP:0002212)2.91600645
22Concave nail (HP:0001598)2.90566353
23Widely patent fontanelles and sutures (HP:0004492)2.90454301
24Tubular atrophy (HP:0000092)2.85439038
25Alopecia of scalp (HP:0002293)2.83118985
26Hyperglycemia (HP:0003074)2.82454470
27Symptomatic seizures (HP:0011145)2.81343249
28Congenital stationary night blindness (HP:0007642)2.80652364
29Dehydration (HP:0001944)2.78691974
30Hypoglycemic coma (HP:0001325)2.74998257
31True hermaphroditism (HP:0010459)2.72764312
32Hyperinsulinemic hypoglycemia (HP:0000825)2.71197675
33Syncope (HP:0001279)2.69955981
34Amelogenesis imperfecta (HP:0000705)2.67750522
35Lip pit (HP:0100267)2.65706414
36Pancreatic fibrosis (HP:0100732)2.65461187
37Large for gestational age (HP:0001520)2.63577882
38Distal lower limb muscle weakness (HP:0009053)2.63119314
39Abnormality of chloride homeostasis (HP:0011422)2.61299020
40Abnormality of midbrain morphology (HP:0002418)2.54656745
41Molar tooth sign on MRI (HP:0002419)2.54656745
42Abnormality of the gastric mucosa (HP:0004295)2.52929367
43Rectal prolapse (HP:0002035)2.49831573
44Hypoplasia of dental enamel (HP:0006297)2.49358928
45Increased IgE level (HP:0003212)2.45858255
46Flat acetabular roof (HP:0003180)2.45643383
47Palpitations (HP:0001962)2.44877131
48Insulin-resistant diabetes mellitus (HP:0000831)2.42342193
49Hypoplasia of the uterus (HP:0000013)2.40517802
50Congenital sensorineural hearing impairment (HP:0008527)2.40017748
51Micronodular cirrhosis (HP:0001413)2.39743679
52Renal cortical cysts (HP:0000803)2.38441685
53Hypoplastic labia majora (HP:0000059)2.38157151
54Conjugated hyperbilirubinemia (HP:0002908)2.35700453
55Aplasia/hypoplasia of the uterus (HP:0008684)2.33796714
56Furrowed tongue (HP:0000221)2.32898926
57Ventricular fibrillation (HP:0001663)2.31881944
58Abnormal pancreas size (HP:0012094)2.28833760
59Ketoacidosis (HP:0001993)2.27147802
60Nail dystrophy (HP:0008404)2.26327542
61Palmoplantar hyperkeratosis (HP:0000972)2.24579303
62Palmar hyperkeratosis (HP:0010765)2.24061087
63Septate vagina (HP:0001153)2.23275051
64Type II lissencephaly (HP:0007260)2.22964851
65Bundle branch block (HP:0011710)2.22508934
66Type I transferrin isoform profile (HP:0003642)2.22369619
67Abnormality of urine glucose concentration (HP:0011016)2.20188553
68Glycosuria (HP:0003076)2.20188553
69Mildly elevated creatine phosphokinase (HP:0008180)2.19664424
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19260510
71Sparse eyelashes (HP:0000653)2.19151949
72Abnormal blistering of the skin (HP:0008066)2.18595019
73Abnormality of the distal phalanges of the toes (HP:0010182)2.17170700
74Abnormality of the renal medulla (HP:0100957)2.16643571
75Abnormality of renin-angiotensin system (HP:0000847)2.14881870
76Unilateral renal agenesis (HP:0000122)2.13908295
77Esophageal atresia (HP:0002032)2.13728476
78Aplasia cutis congenita (HP:0001057)2.12538772
79Cystic liver disease (HP:0006706)2.12127621
80Cheilitis (HP:0100825)2.11905262
81Ketosis (HP:0001946)2.11723981
82Abnormal hair laboratory examination (HP:0003328)2.09870849
83Nephronophthisis (HP:0000090)2.09429166
84Hypothermia (HP:0002045)2.08128338
85Abnormality of the labia majora (HP:0012881)2.07476939
86Acute encephalopathy (HP:0006846)2.06559207
87Hypoglycemic seizures (HP:0002173)2.06036285
88Sudden death (HP:0001699)2.05663229
89Ventricular arrhythmia (HP:0004308)2.05430603
90Abnormality of the salivary glands (HP:0010286)2.04451776
91Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03490600
92Abnormality of vitamin B metabolism (HP:0004340)2.03372317
93Tongue fasciculations (HP:0001308)2.02497700
94Microretrognathia (HP:0000308)2.02190731
95Abnormal vertebral ossification (HP:0100569)2.01619300
96Pterygium (HP:0001059)1.99798399
97Abnormality of proline metabolism (HP:0010907)1.99370690
98Hydroxyprolinuria (HP:0003080)1.99370690
99Decreased circulating renin level (HP:0003351)1.98053481
100Abnormality of aromatic amino acid family metabolism (HP:0004338)1.97460815
101Fragile skin (HP:0001030)1.97083183
102Severe visual impairment (HP:0001141)1.96852367
103Increased connective tissue (HP:0009025)1.95482351
104Uterine neoplasm (HP:0010784)1.95181668
105Lethargy (HP:0001254)1.95111174
106Facial shape deformation (HP:0011334)1.93770275
107Potter facies (HP:0002009)1.93770275
108Proximal tubulopathy (HP:0000114)1.92502362
109Popliteal pterygium (HP:0009756)1.91140406
110Focal segmental glomerulosclerosis (HP:0000097)1.91070205
111Pendular nystagmus (HP:0012043)1.90712913
112Abnormality of vitamin metabolism (HP:0100508)1.90702288
113Exocrine pancreatic insufficiency (HP:0001738)1.89280217
114Congenital, generalized hypertrichosis (HP:0004540)1.88574576
115Abnormality of the vitamin B12 metabolism (HP:0004341)1.87681549
116Acute necrotizing encephalopathy (HP:0006965)1.87607573
117Short humerus (HP:0005792)1.86814378
118Urethral obstruction (HP:0000796)1.86767870
119Attenuation of retinal blood vessels (HP:0007843)1.85691065
120Hyperglycinuria (HP:0003108)1.85553024
121Vascular calcification (HP:0004934)1.85249090
122Abnormality of glycine metabolism (HP:0010895)1.84859200
123Abnormality of serine family amino acid metabolism (HP:0010894)1.84859200
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84828510
125Hypoplastic ischia (HP:0003175)1.84358497
126Chronic bronchitis (HP:0004469)1.84187192
127Abnormality of the 1st metacarpal (HP:0010009)1.83585032
128Vertebral hypoplasia (HP:0008417)1.83221574
129Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.83221574
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.82197453
131Aplasia/hypoplasia of the humerus (HP:0006507)1.81171256
132Adrenal hypoplasia (HP:0000835)1.81136329
133Abnormal biliary tract physiology (HP:0012439)1.80100242
134Bile duct proliferation (HP:0001408)1.80100242
135Hyperaldosteronism (HP:0000859)1.78574770
136Hepatic necrosis (HP:0002605)1.77223067
137Anal stenosis (HP:0002025)1.76911624
138Abnormality of macular pigmentation (HP:0008002)1.76575443
139Confusion (HP:0001289)1.75913681
140Abnormality of nail color (HP:0100643)1.75645015
141Progressive sensorineural hearing impairment (HP:0000408)1.75335919
142Abnormal protein glycosylation (HP:0012346)1.74857248
143Abnormal glycosylation (HP:0012345)1.74857248
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74857248
145Abnormal protein N-linked glycosylation (HP:0012347)1.74857248
146Azoospermia (HP:0000027)1.74337871
147Metabolic acidosis (HP:0001942)1.74154890
148Abnormal rod and cone electroretinograms (HP:0008323)1.73412495
149Palmoplantar keratoderma (HP:0000982)1.73134867
150Male pseudohermaphroditism (HP:0000037)1.73005764
151Hypotrichosis (HP:0001006)1.72857142
152Increased CSF lactate (HP:0002490)1.72741819
153Premature loss of primary teeth (HP:0006323)1.72686238
154Abolished electroretinogram (ERG) (HP:0000550)1.72495053
155Wide cranial sutures (HP:0010537)1.72224422
156Abnormality of renal excretion (HP:0011036)1.71541992
157Chorioretinal atrophy (HP:0000533)1.71119625
158Fat malabsorption (HP:0002630)1.70562044
159Mitochondrial inheritance (HP:0001427)1.70413474
160Congenital ichthyosiform erythroderma (HP:0007431)1.69773642
161Abnormal hemoglobin (HP:0011902)1.69514438
162Sclerocornea (HP:0000647)1.68860029
163Alkalosis (HP:0001948)1.68791541
164Gastrointestinal atresia (HP:0002589)1.65808752
165Malignant gastrointestinal tract tumors (HP:0006749)1.65407256
166Gastrointestinal carcinoma (HP:0002672)1.65407256
167Ependymoma (HP:0002888)1.65083130
168Shawl scrotum (HP:0000049)1.65080428
169Thin bony cortex (HP:0002753)1.64159473
170Trismus (HP:0000211)1.63163210
171Generalized aminoaciduria (HP:0002909)1.62933376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.39528572
2MST1R4.40848053
3FRK4.07462015
4MST43.50931465
5LATS13.12923283
6LMTK23.07293770
7AKT32.63696193
8STK392.56544883
9MAP3K22.46943310
10PIK3CA2.44953709
11MAP4K22.28126617
12IRAK32.24939524
13MET2.14886255
14ADRBK22.00130086
15STK38L1.96840598
16BMPR1B1.92075442
17OXSR11.91967030
18NME11.88770496
19MAP2K21.88388276
20CDK121.84649268
21TRIM281.83529315
22RIPK11.82419530
23FER1.78363698
24DDR21.76696729
25MAP3K121.75854787
26RPS6KB21.62068502
27PASK1.61578492
28PRKG21.52167196
29PTK61.49710503
30TTK1.46721475
31INSRR1.45914590
32EIF2AK11.42251711
33ERN11.41453057
34EPHB21.40690041
35NUAK11.36306957
36MAP3K31.32710310
37TAOK31.26572393
38TTN1.23715635
39CASK1.22073585
40PRKCI1.21271333
41PINK11.20722429
42NEK11.18764583
43MAPKAPK31.12347062
44TLK11.11365074
45STK31.11258593
46PTK21.10753097
47TRPM70.99782694
48PDGFRA0.97404611
49ZAK0.97368364
50STK100.95722362
51VRK20.95042243
52EPHA30.93194339
53PRKCE0.92775045
54TNIK0.88943243
55ERBB30.88419783
56PAK40.88136225
57MAPK150.88028384
58PNCK0.87074868
59MATK0.85052065
60DAPK20.84725304
61MUSK0.82641805
62PIK3CG0.82188008
63MAP3K80.79446007
64PHKG20.78804574
65PHKG10.78804574
66* AURKB0.76910749
67ADRBK10.71001473
68ILK0.69911046
69CDC42BPA0.68081335
70MAP2K10.66438647
71STK240.65999218
72PDK20.63972455
73FLT30.63287858
74MYLK0.62449737
75CDK60.61314042
76BCR0.60912420
77ERBB20.57961448
78TAF10.57388029
79MTOR0.57079199
80PAK30.56326759
81PDK40.55165520
82PDK30.55165520
83ERBB40.54751947
84MAP3K40.54604620
85MAP3K100.53891990
86DYRK1B0.51695301
87CDK70.50862726
88VRK10.50367689
89MAP3K10.48385274
90WNK40.47871094
91TESK10.47799290
92CHUK0.47138807
93CAMK2D0.46950743
94DAPK10.46919857
95TGFBR10.44652840
96EIF2AK20.44279793
97IRAK10.44015828
98ACVR1B0.43739483
99WNK30.43662533
100CDK80.43501692
101CSNK1A10.43099307
102LRRK20.42389458
103GRK10.42085285
104PTK2B0.42064454
105PRKAA20.41852765
106BRSK20.41619151
107HIPK20.40521662
108PRKAA10.40176090
109PBK0.39512208
110TAOK10.39358532
111RPS6KA40.39096836
112MELK0.38835252
113DMPK0.38530147
114ICK0.38517637
115MAP2K70.38193544
116EPHA40.38026019
117BMX0.37983672
118EEF2K0.37058460
119MAP2K60.36661280
120MAPKAPK50.35119621
121OBSCN0.35020327
122AKT20.32908316
123MKNK20.32609179
124TSSK60.32507819
125SCYL20.32493333
126MAP3K90.31283577
127GSK3A0.30982240
128PLK30.30231266
129IKBKB0.30034448
130FGFR10.29581039
131EIF2AK30.29389523
132SIK10.29166896
133STK40.28965561
134RPS6KA10.28590181
135EPHB10.28269774
136ATM0.28001937
137WEE10.26936572
138PLK10.26209538
139FGFR40.26052669
140CSNK1E0.25824669
141BRD40.25181284
142PRKCA0.25142051
143MAPK110.24650108
144IRAK40.24347961
145MAPK130.24026177
146TNK20.23950714
147PKN20.23685346
148CHEK20.23166929
149PRKD20.22125203
150IGF1R0.21661739

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.74319495
2Fat digestion and absorption_Homo sapiens_hsa049753.87194544
3Mineral absorption_Homo sapiens_hsa049783.65940659
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.48319426
5Sulfur metabolism_Homo sapiens_hsa009203.41772805
6Renin-angiotensin system_Homo sapiens_hsa046142.74297130
7Galactose metabolism_Homo sapiens_hsa000522.51316603
8Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.49541431
9Folate biosynthesis_Homo sapiens_hsa007902.29737752
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.27483938
11Protein digestion and absorption_Homo sapiens_hsa049742.20790120
12Vitamin digestion and absorption_Homo sapiens_hsa049772.20640854
13Protein export_Homo sapiens_hsa030602.13851804
14Fructose and mannose metabolism_Homo sapiens_hsa000512.07407364
15Butanoate metabolism_Homo sapiens_hsa006502.00978577
16Adherens junction_Homo sapiens_hsa045201.98150908
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.94886706
18Nitrogen metabolism_Homo sapiens_hsa009101.87380759
19Tight junction_Homo sapiens_hsa045301.79835745
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69892121
21Starch and sucrose metabolism_Homo sapiens_hsa005001.69300776
22Peroxisome_Homo sapiens_hsa041461.56124183
23Phototransduction_Homo sapiens_hsa047441.54080155
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.50714295
25Oxidative phosphorylation_Homo sapiens_hsa001901.47028984
26Bladder cancer_Homo sapiens_hsa052191.46229855
27Fatty acid elongation_Homo sapiens_hsa000621.43047068
28Thyroid cancer_Homo sapiens_hsa052161.43016521
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.42490940
30Primary bile acid biosynthesis_Homo sapiens_hsa001201.42330954
31Ether lipid metabolism_Homo sapiens_hsa005651.41321200
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.39935461
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.39591962
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33538881
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.29631213
36Hippo signaling pathway_Homo sapiens_hsa043901.29302291
37Proteasome_Homo sapiens_hsa030501.24942429
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.18090346
39Pancreatic secretion_Homo sapiens_hsa049721.12631508
40Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12110399
41Bile secretion_Homo sapiens_hsa049761.11523002
42Selenocompound metabolism_Homo sapiens_hsa004501.11290095
43Glutathione metabolism_Homo sapiens_hsa004801.11283951
44One carbon pool by folate_Homo sapiens_hsa006701.10434042
45ECM-receptor interaction_Homo sapiens_hsa045121.09952153
46Histidine metabolism_Homo sapiens_hsa003401.08666233
47Basal cell carcinoma_Homo sapiens_hsa052171.08017145
48Fatty acid degradation_Homo sapiens_hsa000711.07545216
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07411163
50Propanoate metabolism_Homo sapiens_hsa006401.06476958
51Small cell lung cancer_Homo sapiens_hsa052221.05264125
52Tryptophan metabolism_Homo sapiens_hsa003801.04578443
53Sphingolipid metabolism_Homo sapiens_hsa006001.03797988
54Arginine biosynthesis_Homo sapiens_hsa002201.01326057
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.00295535
56RNA polymerase_Homo sapiens_hsa030200.98552396
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97681603
58Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97005018
59Caffeine metabolism_Homo sapiens_hsa002320.96214277
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93617916
61Glycerolipid metabolism_Homo sapiens_hsa005610.92776212
62p53 signaling pathway_Homo sapiens_hsa041150.90250016
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.89892424
64Tyrosine metabolism_Homo sapiens_hsa003500.88982935
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88738615
66Homologous recombination_Homo sapiens_hsa034400.87783532
67Linoleic acid metabolism_Homo sapiens_hsa005910.86984729
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.86629305
69Steroid biosynthesis_Homo sapiens_hsa001000.84260061
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84134511
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.84034019
72Sulfur relay system_Homo sapiens_hsa041220.83348278
73ABC transporters_Homo sapiens_hsa020100.83297165
74Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82737255
75Basal transcription factors_Homo sapiens_hsa030220.81226749
76N-Glycan biosynthesis_Homo sapiens_hsa005100.81150325
77Arachidonic acid metabolism_Homo sapiens_hsa005900.79916112
78Parkinsons disease_Homo sapiens_hsa050120.74788456
79TGF-beta signaling pathway_Homo sapiens_hsa043500.73323176
80Arginine and proline metabolism_Homo sapiens_hsa003300.73174582
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.71945771
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.70694723
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69697836
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68470606
85Lysine degradation_Homo sapiens_hsa003100.67662075
86Huntingtons disease_Homo sapiens_hsa050160.66497276
87Endometrial cancer_Homo sapiens_hsa052130.65619735
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64577185
89Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64367067
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61168476
91Proteoglycans in cancer_Homo sapiens_hsa052050.60777678
92RNA degradation_Homo sapiens_hsa030180.60398080
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59953567
94MicroRNAs in cancer_Homo sapiens_hsa052060.59939979
95Carbon metabolism_Homo sapiens_hsa012000.59890251
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59616104
97Pyrimidine metabolism_Homo sapiens_hsa002400.57292326
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56767077
99Circadian rhythm_Homo sapiens_hsa047100.56131080
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55808382
101Pyruvate metabolism_Homo sapiens_hsa006200.55347860
102Insulin resistance_Homo sapiens_hsa049310.54569510
103Alzheimers disease_Homo sapiens_hsa050100.54422364
104Fanconi anemia pathway_Homo sapiens_hsa034600.54180096
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52483947
106Focal adhesion_Homo sapiens_hsa045100.52483733
107Dilated cardiomyopathy_Homo sapiens_hsa054140.50116541
108Mismatch repair_Homo sapiens_hsa034300.48962207
109Collecting duct acid secretion_Homo sapiens_hsa049660.48949578
110Phenylalanine metabolism_Homo sapiens_hsa003600.48735171
111Purine metabolism_Homo sapiens_hsa002300.47693125
112PPAR signaling pathway_Homo sapiens_hsa033200.47058507
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46601524
114Insulin secretion_Homo sapiens_hsa049110.46136803
115Inositol phosphate metabolism_Homo sapiens_hsa005620.44944850
116Hedgehog signaling pathway_Homo sapiens_hsa043400.43365230
117Vibrio cholerae infection_Homo sapiens_hsa051100.42882651
118Hepatitis C_Homo sapiens_hsa051600.42347976
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.42175733
120Other glycan degradation_Homo sapiens_hsa005110.41800002
121Ribosome_Homo sapiens_hsa030100.41684824
122Type II diabetes mellitus_Homo sapiens_hsa049300.41118710
123Retinol metabolism_Homo sapiens_hsa008300.40883042
124Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.40870393
125Regulation of autophagy_Homo sapiens_hsa041400.40836386
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40663670
127Ovarian steroidogenesis_Homo sapiens_hsa049130.40143390
128Notch signaling pathway_Homo sapiens_hsa043300.40130302
129Prostate cancer_Homo sapiens_hsa052150.39980048
130Vitamin B6 metabolism_Homo sapiens_hsa007500.39091783
131Taste transduction_Homo sapiens_hsa047420.39011307
132Amoebiasis_Homo sapiens_hsa051460.37371356
133RNA transport_Homo sapiens_hsa030130.36749436
134Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36515593
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36494937
136Olfactory transduction_Homo sapiens_hsa047400.35608881
137beta-Alanine metabolism_Homo sapiens_hsa004100.34301020
138Fatty acid metabolism_Homo sapiens_hsa012120.33832907
139Thyroid hormone synthesis_Homo sapiens_hsa049180.32946941
140Chemical carcinogenesis_Homo sapiens_hsa052040.32645904
141Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.32466985
142Pathways in cancer_Homo sapiens_hsa052000.30635146
143Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30109913
144AMPK signaling pathway_Homo sapiens_hsa041520.29830177
145Pentose phosphate pathway_Homo sapiens_hsa000300.29606378
146Fatty acid biosynthesis_Homo sapiens_hsa000610.29478754
147Toxoplasmosis_Homo sapiens_hsa051450.28062280
148Metabolic pathways_Homo sapiens_hsa011000.27678103
149Central carbon metabolism in cancer_Homo sapiens_hsa052300.26042253
150Legionellosis_Homo sapiens_hsa051340.25827185

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