CHMP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of integrin-mediated signaling pathway (GO:2001044)3.24844006
2positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.00345583
3mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95844835
4energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.91547291
5ATP hydrolysis coupled proton transport (GO:0015991)2.91547291
6negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.90157176
7membrane budding (GO:0006900)2.87208470
8membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.85537397
9negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.83801708
10protein neddylation (GO:0045116)2.76214293
11regulation of type B pancreatic cell apoptotic process (GO:2000674)2.74402144
12respiratory electron transport chain (GO:0022904)2.72223303
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.69528173
14electron transport chain (GO:0022900)2.69448814
15membrane raft organization (GO:0031579)2.61278854
16positive regulation of monocyte chemotaxis (GO:0090026)2.57634715
17auditory receptor cell differentiation (GO:0042491)2.56691763
18transferrin transport (GO:0033572)2.54837274
19angiogenesis involved in wound healing (GO:0060055)2.54521980
20detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.54508403
21detection of temperature stimulus involved in sensory perception (GO:0050961)2.54508403
22bundle of His cell to Purkinje myocyte communication (GO:0086069)2.53268380
23neurofilament cytoskeleton organization (GO:0060052)2.51997309
24norepinephrine metabolic process (GO:0042415)2.51697776
25peptidyl-tyrosine autophosphorylation (GO:0038083)2.51312126
26phagosome maturation (GO:0090382)2.50727939
27trivalent inorganic cation transport (GO:0072512)2.48171630
28ferric iron transport (GO:0015682)2.48171630
29macroautophagy (GO:0016236)2.46563010
30regulation of dopamine secretion (GO:0014059)2.45471288
31neuronal action potential propagation (GO:0019227)2.44718568
32energy coupled proton transport, down electrochemical gradient (GO:0015985)2.44170863
33ATP synthesis coupled proton transport (GO:0015986)2.44170863
34negative regulation of cation channel activity (GO:2001258)2.44110907
35negative regulation of protein localization to cell surface (GO:2000009)2.43864080
36fatty acid elongation (GO:0030497)2.43640480
37cellular copper ion homeostasis (GO:0006878)2.43184322
38desmosome organization (GO:0002934)2.41545222
39positive regulation of fatty acid oxidation (GO:0046321)2.38827616
40positive regulation of catecholamine secretion (GO:0033605)2.37249192
41positive regulation of vesicle fusion (GO:0031340)2.36579916
42hypotonic response (GO:0006971)2.34733937
43protein targeting to plasma membrane (GO:0072661)2.34566762
44inositol phosphate-mediated signaling (GO:0048016)2.33834371
45smooth muscle tissue development (GO:0048745)2.32564106
46phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.31515976
47induction of positive chemotaxis (GO:0050930)2.31225246
48regulation of female receptivity (GO:0045924)2.30164611
49regulation of sequestering of triglyceride (GO:0010889)2.28049204
50negative regulation of amino acid transport (GO:0051956)2.25866142
51positive regulation of fatty acid beta-oxidation (GO:0032000)2.24980930
52serotonin metabolic process (GO:0042428)2.24757775
53synaptic vesicle exocytosis (GO:0016079)2.24340364
54protein maturation by protein folding (GO:0022417)2.23907366
55protein localization to endosome (GO:0036010)2.21826531
56regulation of monocyte chemotaxis (GO:0090025)2.21643819
57ER overload response (GO:0006983)2.20776590
58long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.19633122
59hydrogen ion transmembrane transport (GO:1902600)2.19171488
60response to gravity (GO:0009629)2.18467553
61behavioral response to nicotine (GO:0035095)2.17489378
62nitric oxide mediated signal transduction (GO:0007263)2.17023324
63iron ion transport (GO:0006826)2.15366620
64regulation of amyloid precursor protein catabolic process (GO:1902991)2.15178977
65negative regulation of nitric-oxide synthase activity (GO:0051001)2.14662375
66negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.14581983
67negative regulation of calcium ion transmembrane transport (GO:1903170)2.14581983
68regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.14064110
69calcium-mediated signaling using intracellular calcium source (GO:0035584)2.14059149
70positive regulation of glomerulus development (GO:0090193)2.13942256
71keratan sulfate catabolic process (GO:0042340)2.13706464
72regulation of glutamate secretion (GO:0014048)2.13694900
73membrane repolarization during action potential (GO:0086011)2.13427762
74negative regulation of complement activation (GO:0045916)2.13334419
75copper ion homeostasis (GO:0055070)2.13334339
76hemidesmosome assembly (GO:0031581)2.13160073
77long-chain fatty acid biosynthetic process (GO:0042759)2.13004417
78phospholipid scrambling (GO:0017121)2.12499469
79mitochondrial calcium ion homeostasis (GO:0051560)2.12382679
80type B pancreatic cell proliferation (GO:0044342)2.12213404
81long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.10971423
82positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.10631790
83negative regulation of dendrite morphogenesis (GO:0050774)2.10617308
84positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.08771427
85primary amino compound metabolic process (GO:1901160)2.08678158
86membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.07924162
87regulation of synaptic vesicle exocytosis (GO:2000300)2.07456983
88cardiac conduction (GO:0061337)2.06478174
89negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.06432392
90cell adhesion mediated by integrin (GO:0033627)2.06320360
91detection of temperature stimulus (GO:0016048)2.05774275
92barbed-end actin filament capping (GO:0051016)2.04280304
93regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.04156188
94fatty-acyl-CoA metabolic process (GO:0035337)2.03521767
95adhesion of symbiont to host cell (GO:0044650)2.03338003
96virion attachment to host cell (GO:0019062)2.03338003
97positive regulation of actin filament depolymerization (GO:0030836)2.02321575
98myelin maintenance (GO:0043217)2.02286452
99proton transport (GO:0015992)2.02185907
100glutamate secretion (GO:0014047)2.01319501
101activation of protein kinase B activity (GO:0032148)2.00738934
102regulation of macrophage derived foam cell differentiation (GO:0010743)2.00484337
103negative regulation of response to reactive oxygen species (GO:1901032)2.00231711
104hydrogen transport (GO:0006818)1.99665535
105sequestering of actin monomers (GO:0042989)1.99299869
106detection of bacterium (GO:0016045)1.99139531
107sequestering of extracellular ligand from receptor (GO:0035581)1.99031493
108interleukin-1-mediated signaling pathway (GO:0070498)1.98949134
109positive regulation of receptor recycling (GO:0001921)1.98887224
110regulation of heart rate by cardiac conduction (GO:0086091)1.98591788
111regulation of glomerulus development (GO:0090192)1.97989695
112positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)1.97926435
113negative regulation of glycogen metabolic process (GO:0070874)1.96362030
114transcytosis (GO:0045056)1.95445684
115regulation of receptor binding (GO:1900120)1.94261836
116long term synaptic depression (GO:0060292)1.94036544
117aldehyde catabolic process (GO:0046185)1.93516740
118detection of other organism (GO:0098543)1.92928806
119regulation of cell communication by electrical coupling (GO:0010649)1.91918963
120regulation of voltage-gated calcium channel activity (GO:1901385)1.91605970
121pattern specification involved in kidney development (GO:0061004)1.91391834
122regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)1.91157130
123negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.91029101
124regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022351.90971765
125cellular iron ion homeostasis (GO:0006879)1.89987833
126glutathione derivative metabolic process (GO:1901685)1.89501642
127glutathione derivative biosynthetic process (GO:1901687)1.89501642
128cellular transition metal ion homeostasis (GO:0046916)1.89370165
129mating behavior (GO:0007617)1.88311599
130glutathione biosynthetic process (GO:0006750)1.88165388
131tonic smooth muscle contraction (GO:0014820)1.88154589
132synaptic vesicle maturation (GO:0016188)1.88017599
133regulation of fatty acid oxidation (GO:0046320)1.87881179
134amyloid precursor protein catabolic process (GO:0042987)1.87589759
135response to water (GO:0009415)1.87292505
136fatty-acyl-CoA biosynthetic process (GO:0046949)1.86876850
137amyloid precursor protein metabolic process (GO:0042982)1.86862964
138negative regulation of ion transmembrane transporter activity (GO:0032413)1.86528324
139positive regulation of cardiac muscle cell differentiation (GO:2000727)1.86436666
140regulation of lipoprotein metabolic process (GO:0050746)1.86047174
141positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)1.85808491
142NADH metabolic process (GO:0006734)1.84526066
143regulation of transforming growth factor beta1 production (GO:0032908)1.84519095
144actin filament depolymerization (GO:0030042)1.84456772
145female mating behavior (GO:0060180)1.84249524
146succinate metabolic process (GO:0006105)1.83830620
147positive regulation of glycolytic process (GO:0045821)1.83700295
148membrane assembly (GO:0071709)1.83190201
149plasma membrane repair (GO:0001778)1.83018259
150negative regulation of protein activation cascade (GO:2000258)1.82937961
151sphingoid metabolic process (GO:0046519)1.82412402
152Golgi to plasma membrane protein transport (GO:0043001)1.81896450
153regulation of phospholipase A2 activity (GO:0032429)1.81028627
154extracellular fibril organization (GO:0043206)1.80761107
155negative regulation of platelet activation (GO:0010544)1.80050897
156regulation of autophagic vacuole assembly (GO:2000785)1.78605827
157relaxation of smooth muscle (GO:0044557)1.77979034
158negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.77369329
159detection of calcium ion (GO:0005513)1.77196845
160establishment of protein localization to plasma membrane (GO:0090002)1.76977851
161regulation of cholesterol storage (GO:0010885)1.76735133
162astrocyte differentiation (GO:0048708)1.76233705
163endocardial cushion development (GO:0003197)1.75986108
164negative regulation of lipid storage (GO:0010888)1.75740712
165peptide hormone processing (GO:0016486)1.75440027
166negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)1.74876851
167regulation of metalloenzyme activity (GO:0048552)1.74244768
168negative regulation of glycogen biosynthetic process (GO:0045719)1.74243887
169growth hormone receptor signaling pathway (GO:0060396)1.74042549
170regulation of memory T cell differentiation (GO:0043380)1.72884114
171negative regulation of response to food (GO:0032096)1.72479550
172negative regulation of appetite (GO:0032099)1.72479550
173positive regulation of phosphatase activity (GO:0010922)1.72362581
174regulation of protein localization to cell surface (GO:2000008)1.70643217
175regulation of calcineurin-NFAT signaling cascade (GO:0070884)1.69599195
176sarcomere organization (GO:0045214)1.68087284
177glandular epithelial cell differentiation (GO:0002067)1.67605011
178magnesium ion transport (GO:0015693)1.67475323
179fibril organization (GO:0097435)1.66824807
180muscle cell migration (GO:0014812)1.66761822
181calcium ion-dependent exocytosis (GO:0017156)1.66170056
182regulation of skeletal muscle contraction (GO:0014819)1.66036664
183cellular potassium ion homeostasis (GO:0030007)1.65958466
184regulation of receptor recycling (GO:0001919)1.65774051
185peptide catabolic process (GO:0043171)1.65465930
186termination of signal transduction (GO:0023021)1.65372872
187dendritic spine morphogenesis (GO:0060997)1.65253978

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human2.63444246
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.58743947
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.41889016
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.38809598
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.24219189
6NRF2_20460467_ChIP-Seq_MEFs_Mouse2.18679999
7NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.18679999
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.10656936
9CDX2_19796622_ChIP-Seq_MESCs_Mouse2.03357033
10EZH2_22144423_ChIP-Seq_EOC_Human1.99606260
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.95960459
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.95712845
13GBX2_23144817_ChIP-Seq_PC3_Human1.86968110
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85939146
15ESR1_20079471_ChIP-ChIP_T-47D_Human1.84784708
16SOX2_20726797_ChIP-Seq_SW620_Human1.84724415
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80433228
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.69335884
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.68394881
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.67034527
21NR3C1_23031785_ChIP-Seq_PC12_Mouse1.64960232
22PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.61166036
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.60437834
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.59174419
25ESR1_21235772_ChIP-Seq_MCF-7_Human1.58891503
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54531020
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53577236
28AR_21572438_ChIP-Seq_LNCaP_Human1.52129794
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47759544
30CLOCK_20551151_ChIP-Seq_293T_Human1.45799708
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.44427429
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37793200
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.36479292
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.35897958
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.35897958
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.35471224
37Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34897048
38CJUN_26792858_Chip-Seq_BT549_Human1.33774838
39ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32459812
40TP53_18474530_ChIP-ChIP_U2OS_Human1.32126571
41IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32094243
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.30962912
43CDX2_20551321_ChIP-Seq_CACO-2_Human1.29892593
44SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29668693
45TAF15_26573619_Chip-Seq_HEK293_Human1.28880269
46EED_16625203_ChIP-ChIP_MESCs_Mouse1.28003179
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27711642
48ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27343634
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22769370
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.19017468
51TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16983560
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16415763
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.15290349
54GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15174744
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14690816
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.12156923
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.11900530
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.11823944
59SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08634007
60ZNF263_19887448_ChIP-Seq_K562_Human1.08320411
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07923721
62LXR_22158963_ChIP-Seq_LIVER_Mouse1.07632157
63BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07243072
64AR_25329375_ChIP-Seq_VCAP_Human1.06959370
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03991112
66RXR_22158963_ChIP-Seq_LIVER_Mouse1.03467795
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02849678
68FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02506717
69SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02038491
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00872784
71SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00872738
72PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99419768
73TP63_23658742_ChIP-Seq_EP156T_Human0.97588562
74RXR_22108803_ChIP-Seq_LS180_Human0.97334189
75WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96730497
76NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96298519
77SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96175633
78CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96103751
79GATA4_25053715_ChIP-Seq_YYC3_Human0.95592942
80NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.95026344
81BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94902741
82SMAD4_21799915_ChIP-Seq_A2780_Human0.93858427
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93252109
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.93190728
85MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92684529
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92667186
87FOXO3_23340844_ChIP-Seq_DLD1_Human0.92654785
88TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91716105
89SOX2_19829295_ChIP-Seq_ESCs_Human0.91177165
90NANOG_19829295_ChIP-Seq_ESCs_Human0.91177165
91EZH2_27294783_Chip-Seq_ESCs_Mouse0.89660537
92TBX20_22328084_ChIP-Seq_HEART_Mouse0.89235944
93TBX20_22080862_ChIP-Seq_HEART_Mouse0.89235944
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88938301
95EGR1_19032775_ChIP-ChIP_M12_Human0.88892925
96SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88778978
97ERG_21242973_ChIP-ChIP_JURKAT_Human0.88609692
98AHR_22903824_ChIP-Seq_MCF-7_Human0.87700998
99P63_26484246_Chip-Seq_KERATINOCYTES_Human0.87696472
100EOMES_21245162_ChIP-Seq_HESCs_Human0.87647391
101P300_19829295_ChIP-Seq_ESCs_Human0.86733743
102ARNT_22903824_ChIP-Seq_MCF-7_Human0.86603676
103SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85667746
104EZH2_27304074_Chip-Seq_ESCs_Mouse0.85661433
105CDX2_22108803_ChIP-Seq_LS180_Human0.85298709
106ER_23166858_ChIP-Seq_MCF-7_Human0.85197911
107TP53_16413492_ChIP-PET_HCT116_Human0.84587652
108SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.84496456
109DROSHA_22980978_ChIP-Seq_HELA_Human0.84396180
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.84132228
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.84132228
112AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83718864
113THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.83027949
114TP53_23651856_ChIP-Seq_MEFs_Mouse0.82822332
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82590502
116EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82337031
117STAT6_21828071_ChIP-Seq_BEAS2B_Human0.82002341
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.81775629
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.81449204
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.81258734
121FOXA1_21572438_ChIP-Seq_LNCaP_Human0.81068173
122FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81021301
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80838166
124RUNX_20019798_ChIP-Seq_JUKART_Human0.80743692
125STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.80462998
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79982385
127GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78881104
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.78656880
129BCAT_22108803_ChIP-Seq_LS180_Human0.78119935
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78028308
131JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77386167
132RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77209252
133VDR_24787735_ChIP-Seq_THP-1_Human0.76986642
134PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76479651
135TCF4_18268006_ChIP-ChIP_LS174T_Human0.75811141
136IRF8_22096565_ChIP-ChIP_GC-B_Human0.74518526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy3.64449349
2MP0004147_increased_porphyrin_level3.28134596
3MP0010234_abnormal_vibrissa_follicle2.84353061
4MP0002735_abnormal_chemical_nociception2.69246720
5MP0005275_abnormal_skin_tensile2.41071330
6MP0002736_abnormal_nociception_after2.32142344
7MP0001968_abnormal_touch/_nociception2.30463233
8MP0009379_abnormal_foot_pigmentation2.29241110
9MP0005058_abnormal_lysosome_morphology2.21804140
10MP0008438_abnormal_cutaneous_collagen2.12344622
11MP0003195_calcinosis2.09225612
12MP0004270_analgesia2.08974340
13MP0010386_abnormal_urinary_bladder2.06565221
14MP0000013_abnormal_adipose_tissue2.02527180
15MP0005167_abnormal_blood-brain_barrier1.94308945
16MP0002796_impaired_skin_barrier1.91805499
17MP0003646_muscle_fatigue1.91649330
18MP0002733_abnormal_thermal_nociception1.87026779
19MP0002295_abnormal_pulmonary_circulatio1.75742404
20MP0005083_abnormal_biliary_tract1.74616227
21MP0002734_abnormal_mechanical_nocicepti1.72889654
22MP0004043_abnormal_pH_regulation1.72281602
23MP0001970_abnormal_pain_threshold1.68743401
24MP0005503_abnormal_tendon_morphology1.67573038
25MP0008875_abnormal_xenobiotic_pharmacok1.67458007
26MP0008775_abnormal_heart_ventricle1.63818221
27MP0004885_abnormal_endolymph1.57013243
28MP0002837_dystrophic_cardiac_calcinosis1.56115172
29MP0005408_hypopigmentation1.56066179
30MP0003191_abnormal_cellular_cholesterol1.55561286
31MP0003329_amyloid_beta_deposits1.50910954
32MP0002909_abnormal_adrenal_gland1.48153009
33MP0005171_absent_coat_pigmentation1.46319350
34MP0003806_abnormal_nucleotide_metabolis1.46275417
35MP0005464_abnormal_platelet_physiology1.45377210
36MP0005085_abnormal_gallbladder_physiolo1.43947127
37MP0003011_delayed_dark_adaptation1.43711632
38MP0001905_abnormal_dopamine_level1.43213136
39MP0000372_irregular_coat_pigmentation1.42274119
40MP0005646_abnormal_pituitary_gland1.42255648
41MP0001986_abnormal_taste_sensitivity1.41737384
42MP0003186_abnormal_redox_activity1.41507363
43MP0001533_abnormal_skeleton_physiology1.41289937
44MP0003950_abnormal_plasma_membrane1.40559000
45MP0010678_abnormal_skin_adnexa1.39667711
46MP0008004_abnormal_stomach_pH1.38743656
47MP0003656_abnormal_erythrocyte_physiolo1.36021284
48MP0005409_darkened_coat_color1.33345408
49MP0003638_abnormal_response/metabolism_1.31829386
50MP0003828_pulmonary_edema1.31790964
51MP0003690_abnormal_glial_cell1.31509928
52MP0005084_abnormal_gallbladder_morpholo1.30687037
53MP0004859_abnormal_synaptic_plasticity1.30245408
54MP0001542_abnormal_bone_strength1.28052641
55MP0005670_abnormal_white_adipose1.27760586
56MP0000920_abnormal_myelination1.26851786
57MP0005360_urolithiasis1.26366156
58MP0001756_abnormal_urination1.26095014
59MP0000383_abnormal_hair_follicle1.23898842
60MP0004272_abnormal_basement_membrane1.23551322
61MP0003880_abnormal_central_pattern1.23463349
62MP0001765_abnormal_ion_homeostasis1.23429902
63MP0004510_myositis1.23427298
64MP0003183_abnormal_peptide_metabolism1.20530825
65MP0002064_seizures1.19999939
66MP0002896_abnormal_bone_mineralization1.19339955
67MP0003633_abnormal_nervous_system1.16683255
68MP0002272_abnormal_nervous_system1.15874921
69MP0002139_abnormal_hepatobiliary_system1.15378434
70MP0004858_abnormal_nervous_system1.14352305
71MP0009745_abnormal_behavioral_response1.12794079
72MP0000604_amyloidosis1.11710431
73MP0000427_abnormal_hair_cycle1.11575427
74MP0001440_abnormal_grooming_behavior1.10538810
75MP0003279_aneurysm1.10188703
76MP0005165_increased_susceptibility_to1.08919084
77MP0000749_muscle_degeneration1.07762928
78MP0003635_abnormal_synaptic_transmissio1.07325686
79MP0009780_abnormal_chondrocyte_physiolo1.06421387
80MP0005636_abnormal_mineral_homeostasis1.05807160
81MP0009046_muscle_twitch1.05640452
82MP0006276_abnormal_autonomic_nervous1.04550034
83MP0005257_abnormal_intraocular_pressure1.02983685
84MP0003724_increased_susceptibility_to1.01147885
85MP0004215_abnormal_myocardial_fiber1.00410311
86MP0000230_abnormal_systemic_arterial0.99710946
87MP0004484_altered_response_of0.98511501
88MP0009643_abnormal_urine_homeostasis0.97820651
89MP0005620_abnormal_muscle_contractility0.97184798
90MP0001666_abnormal_nutrient_absorption0.95835216
91MP0001879_abnormal_lymphatic_vessel0.94773905
92MP0001529_abnormal_vocalization0.94636473
93MP0002877_abnormal_melanocyte_morpholog0.93065477
94MP0005023_abnormal_wound_healing0.92727766
95MP0000751_myopathy0.91891056
96MP0002971_abnormal_brown_adipose0.91088518
97MP0004019_abnormal_vitamin_homeostasis0.90798990
98MP0002090_abnormal_vision0.90792346
99MP0000538_abnormal_urinary_bladder0.90707566
100MP0003566_abnormal_cell_adhesion0.90543462
101MP0005390_skeleton_phenotype0.88807542
102MP0005164_abnormal_response_to0.88388152
103MP0010771_integument_phenotype0.88273209
104MP0004036_abnormal_muscle_relaxation0.88171101
105MP0002060_abnormal_skin_morphology0.88055243
106MP0001958_emphysema0.87972105
107MP0001501_abnormal_sleep_pattern0.87603863
108MP0005332_abnormal_amino_acid0.87381635
109MP0003075_altered_response_to0.86996860
110MP0004145_abnormal_muscle_electrophysio0.86888730
111MP0010368_abnormal_lymphatic_system0.86748741
112MP0004084_abnormal_cardiac_muscle0.86068363
113MP0009053_abnormal_anal_canal0.85900243
114MP0004130_abnormal_muscle_cell0.84769460
115MP0004085_abnormal_heartbeat0.84488496
116MP0005385_cardiovascular_system_phenoty0.83174058
117MP0001544_abnormal_cardiovascular_syste0.83174058
118MP0000767_abnormal_smooth_muscle0.82697826
119MP0006036_abnormal_mitochondrial_physio0.82612532
120MP0000678_abnormal_parathyroid_gland0.82501322
121MP0003045_fibrosis0.82269908
122MP0009384_cardiac_valve_regurgitation0.82045200
123MP0000747_muscle_weakness0.81757069
124MP0005535_abnormal_body_temperature0.81450074
125MP0000467_abnormal_esophagus_morphology0.80681148
126MP0001664_abnormal_digestion0.79944436
127MP0005595_abnormal_vascular_smooth0.79772157
128MP0006054_spinal_hemorrhage0.79234667
129MP0002118_abnormal_lipid_homeostasis0.79022378
130MP0000343_altered_response_to0.78986229
131MP0002876_abnormal_thyroid_physiology0.78452047
132MP0003631_nervous_system_phenotype0.78316366
133MP0003705_abnormal_hypodermis_morpholog0.77942296
134MP0008874_decreased_physiological_sensi0.77742003
135MP0005501_abnormal_skin_physiology0.77409516
136MP0003879_abnormal_hair_cell0.77081724
137MP0005448_abnormal_energy_balance0.76069652
138MP0002972_abnormal_cardiac_muscle0.75731957
139MP0002998_abnormal_bone_remodeling0.73986567
140MP0003300_gastrointestinal_ulcer0.73267141
141MP0010329_abnormal_lipoprotein_level0.73262281
142MP0001348_abnormal_lacrimal_gland0.73145397
143MP0004947_skin_inflammation0.72885270
144MP0003436_decreased_susceptibility_to0.72761657
145MP0002067_abnormal_sensory_capabilities0.72655718
146MP0002063_abnormal_learning/memory/cond0.71651524
147MP0004883_abnormal_blood_vessel0.71572578
148MP0006138_congestive_heart_failure0.68453880
149MP0000465_gastrointestinal_hemorrhage0.68429068
150MP0000249_abnormal_blood_vessel0.67985396
151MP0005379_endocrine/exocrine_gland_phen0.65698625

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.04957128
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.55132685
3Axonal loss (HP:0003447)3.42749622
4Ventricular fibrillation (HP:0001663)3.23733225
5Bundle branch block (HP:0011710)3.22722456
6Hypothermia (HP:0002045)3.16125405
7Acute necrotizing encephalopathy (HP:0006965)3.05380357
8Atonic seizures (HP:0010819)2.94988952
9Cardiovascular calcification (HP:0011915)2.91763253
10Vascular calcification (HP:0004934)2.91692308
11Abnormal mitochondria in muscle tissue (HP:0008316)2.87861034
12Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.80476670
13Acute encephalopathy (HP:0006846)2.79354574
14Mitral stenosis (HP:0001718)2.73483908
15Vacuolated lymphocytes (HP:0001922)2.69869712
16Right ventricular cardiomyopathy (HP:0011663)2.67277960
17Progressive macrocephaly (HP:0004481)2.66147959
18Ileus (HP:0002595)2.66132064
19Ulnar claw (HP:0001178)2.64692497
20Type 1 muscle fiber predominance (HP:0003803)2.63704941
21Hematochezia (HP:0002573)2.59690659
22Abnormality of magnesium homeostasis (HP:0004921)2.55803191
23Congenital sensorineural hearing impairment (HP:0008527)2.52646357
24Increased cerebral lipofuscin (HP:0011813)2.52105412
25Protrusio acetabuli (HP:0003179)2.52058131
26Striae distensae (HP:0001065)2.51146749
27Pheochromocytoma (HP:0002666)2.49853927
28Mitochondrial inheritance (HP:0001427)2.49266792
29Congenital ichthyosiform erythroderma (HP:0007431)2.47306543
30Asymmetric septal hypertrophy (HP:0001670)2.46618096
31Cerebral hemorrhage (HP:0001342)2.46343894
32Increased neuronal autofluorescent lipopigment (HP:0002074)2.46041576
33Bone cyst (HP:0012062)2.45011170
34Oligomenorrhea (HP:0000876)2.44228052
35Metaphyseal dysplasia (HP:0100255)2.42710127
36Mildly elevated creatine phosphokinase (HP:0008180)2.40752373
37Myotonia (HP:0002486)2.40024823
38Sensorimotor neuropathy (HP:0007141)2.39048894
39Ventricular arrhythmia (HP:0004308)2.37915655
40Syncope (HP:0001279)2.37266760
41Nemaline bodies (HP:0003798)2.36908921
42Hypomagnesemia (HP:0002917)2.36349921
43Neuroendocrine neoplasm (HP:0100634)2.33813727
44Decreased circulating renin level (HP:0003351)2.32175666
45Systemic lupus erythematosus (HP:0002725)2.30684210
46Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.29002806
47Segmental peripheral demyelination/remyelination (HP:0003481)2.28384750
48Focal motor seizures (HP:0011153)2.25760470
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.24627349
50Urinary glycosaminoglycan excretion (HP:0003541)2.24319252
51Mucopolysacchariduria (HP:0008155)2.24319252
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.22544152
53Abnormality of polysaccharide metabolism (HP:0011012)2.22544152
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.22544152
55Vascular tortuosity (HP:0004948)2.21852487
56Hyperlipoproteinemia (HP:0010980)2.21599053
57Abnormality of calcium-phosphate metabolism (HP:0100530)2.17662420
58Menorrhagia (HP:0000132)2.17452750
59Insulin-resistant diabetes mellitus (HP:0000831)2.17155760
60Abnormal hemoglobin (HP:0011902)2.16153134
61Fatigable weakness (HP:0003473)2.14533357
62Abnormality of the neuromuscular junction (HP:0003398)2.14533357
63Muscle stiffness (HP:0003552)2.14187516
64Autoamputation (HP:0001218)2.13348371
65Aortic aneurysm (HP:0004942)2.13307239
66Neurofibrillary tangles (HP:0002185)2.12437183
67Prolonged bleeding time (HP:0003010)2.11277866
68Aortic dissection (HP:0002647)2.09291146
69Hyporeflexia of lower limbs (HP:0002600)2.08952427
70Xanthomatosis (HP:0000991)2.08777806
71Hyperthyroidism (HP:0000836)2.08181161
72Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.07712354
73Follicular hyperkeratosis (HP:0007502)2.07484117
74Muscle fiber inclusion bodies (HP:0100299)2.05795178
75Hepatocellular necrosis (HP:0001404)2.05259222
76Parakeratosis (HP:0001036)2.05107473
77Thick nail (HP:0001805)2.04215833
78Abnormality of the proximal phalanges of the hand (HP:0009834)2.03757797
79Neck muscle weakness (HP:0000467)2.03087933
80Conjunctival hamartoma (HP:0100780)2.02636659
81Ulnar deviation of the wrist (HP:0003049)2.02233113
82Hyperphosphatemia (HP:0002905)2.00428503
83Hepatic necrosis (HP:0002605)1.99925386
84Arterial tortuosity (HP:0005116)1.99120608
85Adrenal hypoplasia (HP:0000835)1.98732752
86Increased CSF protein (HP:0002922)1.98289251
87Peritonitis (HP:0002586)1.96894979
88Hyperactive renin-angiotensin system (HP:0000841)1.96305047
89Increased CSF lactate (HP:0002490)1.96090451
90Palpitations (HP:0001962)1.94372303
91Bradycardia (HP:0001662)1.94343032
92Vertebral compression fractures (HP:0002953)1.94231619
93Abnormal atrioventricular conduction (HP:0005150)1.94020700
94Cerebral edema (HP:0002181)1.93371885
95Abnormal gallbladder physiology (HP:0012438)1.92431084
96Cholecystitis (HP:0001082)1.92431084
97Acanthosis nigricans (HP:0000956)1.91361023
98Round ear (HP:0100830)1.91337767
99Skin nodule (HP:0200036)1.91044119
100Abnormal EKG (HP:0003115)1.90744247
101Decreased central vision (HP:0007663)1.89791747
102Action tremor (HP:0002345)1.89594938
103Beaking of vertebral bodies (HP:0004568)1.89038428
104Spinal rigidity (HP:0003306)1.89036723
105Termporal pattern (HP:0011008)1.88918192
106Insidious onset (HP:0003587)1.88918192
107Respiratory failure (HP:0002878)1.87996777
108Absence seizures (HP:0002121)1.87365875
109Dysostosis multiplex (HP:0000943)1.84779638
110Increased circulating renin level (HP:0000848)1.84578815
111Cervical subluxation (HP:0003308)1.83599704
112Agitation (HP:0000713)1.83157862
113Hypokalemic alkalosis (HP:0001949)1.81688209
114Glucose intolerance (HP:0000833)1.81553611
115Increased intramyocellular lipid droplets (HP:0012240)1.81252013
116Distal lower limb muscle weakness (HP:0009053)1.80000458
117Alopecia of scalp (HP:0002293)1.79150835
118Atrophic scars (HP:0001075)1.79042849
119Hyperglycemia (HP:0003074)1.78570605
120Atrial fibrillation (HP:0005110)1.78270288
121Amyloidosis (HP:0011034)1.78011844
122Abnormality of renin-angiotensin system (HP:0000847)1.77558373
123Purpura (HP:0000979)1.77281747
124Premature rupture of membranes (HP:0001788)1.76897453
125Abnormality of the costochondral junction (HP:0000919)1.76705003
126Absent/shortened dynein arms (HP:0200106)1.76325104
127Dynein arm defect of respiratory motile cilia (HP:0012255)1.76325104
128Sensory axonal neuropathy (HP:0003390)1.76320742
129Increased muscle lipid content (HP:0009058)1.76010542
130Absent phalangeal crease (HP:0006109)1.75114504
131Reduced subcutaneous adipose tissue (HP:0003758)1.75065671
132Testicular neoplasm (HP:0010788)1.74255816
133Foot dorsiflexor weakness (HP:0009027)1.72575728
134Growth hormone excess (HP:0000845)1.72201619
135Sudden death (HP:0001699)1.71788204
136Heart block (HP:0012722)1.71666120
137Cerebral inclusion bodies (HP:0100314)1.70615914
138Joint stiffness (HP:0001387)1.68403417
139Abnormality of proline metabolism (HP:0010907)1.68346911
140Hydroxyprolinuria (HP:0003080)1.68346911
141Hypokinesia (HP:0002375)1.67729408
142Metabolic alkalosis (HP:0200114)1.67458521
143Abnormality of Sharpey fibers (HP:0100685)1.66726478
144Dialeptic seizures (HP:0011146)1.66527819
145Postural tremor (HP:0002174)1.66003619
146Hyperparathyroidism (HP:0000843)1.65295208
147Chondrocalcinosis (HP:0000934)1.65026576
148Osteoarthritis (HP:0002758)1.64731189
149Torticollis (HP:0000473)1.64189675
150Abnormality of glutamine family amino acid metabolism (HP:0010902)1.63931976
151Keratoconus (HP:0000563)1.63804166
152Increased corneal curvature (HP:0100692)1.63804166
153X-linked dominant inheritance (HP:0001423)1.63710168
154Loss of speech (HP:0002371)1.63250103
155Episodic fever (HP:0001954)1.63030257
156Primary atrial arrhythmia (HP:0001692)1.62873463
157Abnormality of the vocal cords (HP:0008777)1.62289053
158Abnormality of complement system (HP:0005339)1.62285863
159Spinal canal stenosis (HP:0003416)1.61564190
160Short femoral neck (HP:0100864)1.61295545
161Congenital stationary night blindness (HP:0007642)1.61141545
162Abnormality of the nasal septum (HP:0000419)1.60671145
163Supraventricular tachycardia (HP:0004755)1.60267966
164Anxiety (HP:0000739)1.59952532
165Abnormality of glycosphingolipid metabolism (HP:0004343)1.58931751
166Abnormality of glycolipid metabolism (HP:0010969)1.58931751
167Stridor (HP:0010307)1.58429142
168Glomerulonephritis (HP:0000099)1.58259364
169Hypoglycemic coma (HP:0001325)1.57738394
170Abnormal eating behavior (HP:0100738)1.57238807
171Glycosuria (HP:0003076)1.57206953
172Abnormality of urine glucose concentration (HP:0011016)1.57206953
173Renal Fanconi syndrome (HP:0001994)1.57152317
174Upper limb amyotrophy (HP:0009129)1.56891813
175Distal upper limb amyotrophy (HP:0007149)1.56891813
176Onion bulb formation (HP:0003383)1.56688654
177Craniofacial dystonia (HP:0012179)1.56594677
178Abnormal autonomic nervous system physiology (HP:0012332)1.56551976
179Resting tremor (HP:0002322)1.56417417
180Focal seizures (HP:0007359)1.56243682
181Progressive inability to walk (HP:0002505)1.56171745
182Dysautonomia (HP:0002459)1.55837563
183Increased connective tissue (HP:0009025)1.55365235
184Fragile skin (HP:0001030)1.55069251
185Plantar hyperkeratosis (HP:0007556)1.54731178
186Exercise intolerance (HP:0003546)1.53926595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ARAF3.23068885
2MAP3K122.96980100
3KSR22.65406792
4MAP3K22.63581848
5MST1R2.32818779
6FRK2.32388385
7NTRK12.27360282
8GRK52.25399849
9RIPK42.20478616
10LIMK12.14625563
11STK392.14219962
12MYLK2.06389578
13MST41.91642489
14MAP3K91.85747731
15EPHB21.82447050
16WNK41.81839150
17CAMKK21.72782050
18BCR1.70550791
19MAP2K11.70450933
20PIM21.70294373
21PHKG21.69573077
22PHKG11.69573077
23FER1.67711688
24MINK11.63579656
25OXSR11.62674748
26PINK11.59384474
27MET1.57820538
28TESK11.52147275
29TIE11.50363424
30MAPKAPK51.48709031
31MAP2K21.45693468
32LMTK21.37463095
33SIK31.30094765
34TAOK31.29211609
35PLK21.27999154
36MAPKAPK31.27303206
37RIPK11.23678171
38EPHA41.23512253
39DAPK21.21007226
40MAP3K61.20888375
41BMPR21.14470042
42PTK2B1.13407612
43NTRK31.13175661
44PIK3CA1.08862653
45ZAP701.08372558
46INSRR1.07831050
47EPHB11.07778301
48TRPM71.06413326
49SIK11.06045218
50MAP2K31.04313363
51MAP2K61.03437124
52NME21.03361455
53MAP3K11.03009504
54STK381.01675963
55ACVR1B1.00424933
56DMPK1.00393658
57MAP3K30.99075715
58GRK70.98840429
59LRRK20.98821839
60PDK20.97617898
61PRKG20.97564814
62ADRBK20.96894982
63DAPK30.96625844
64MUSK0.95057553
65SGK2230.94874468
66SGK4940.94874468
67EPHA30.94654024
68OBSCN0.93882645
69PRKCE0.89196087
70GRK10.87213031
71RET0.86391957
72WNK10.85325199
73BRAF0.84044351
74PRKD20.79988064
75PBK0.79966884
76RAF10.78961048
77ROCK10.78949397
78CDC42BPA0.77908792
79CSK0.77162251
80PAK30.76939990
81MOS0.76367558
82CASK0.74059704
83CAMKK10.71471844
84IRAK30.71223799
85MAP2K40.70942965
86CAMK2D0.69691792
87BCKDK0.67449944
88RPS6KA20.66008847
89TESK20.65903931
90STK240.64498511
91ADRBK10.64255958
92PRKAA20.64086532
93SGK30.62980308
94PDPK10.62858458
95ILK0.62673195
96CAMK2G0.62271596
97CAMK10.61522650
98CAMK2B0.61230626
99JAK10.60927985
100ABL20.60872200
101ERN10.60609952
102NME10.60486070
103STK30.58646641
104PDGFRB0.58617318
105NEK90.58266803
106CAMK2A0.56683606
107CDK50.55356741
108MAP3K130.54842954
109HIPK20.54261489
110IKBKB0.51529944
111PIK3CG0.50553400
112CHUK0.50370788
113SGK20.49029214
114ERBB20.48366116
115PRKD30.48317108
116PRKD10.47830165
117AKT30.47168632
118TGFBR20.47012816
119EPHA20.46930969
120CDK140.46820146
121PAK60.42564008
122MATK0.42079072
123LATS20.41585046
124PTK20.40091225
125ROCK20.39868615
126KSR10.39688789
127TTN0.38795631
128PDK10.38284238
129PRKCH0.36757497
130CDK180.34442942
131FYN0.33990686
132PRKCG0.33914290
133DDR20.32601612
134PRKCA0.32500873
135PRKACA0.31785708
136SRC0.30757755
137IGF1R0.30169368
138PRKCD0.30092462
139SCYL20.28682060
140ERBB30.28619173

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001903.03084692
2Collecting duct acid secretion_Homo sapiens_hsa049662.74216762
3Sulfur metabolism_Homo sapiens_hsa009202.42830778
4Parkinsons disease_Homo sapiens_hsa050122.29727662
5Synaptic vesicle cycle_Homo sapiens_hsa047212.18392633
6Alzheimers disease_Homo sapiens_hsa050102.08097701
7Vibrio cholerae infection_Homo sapiens_hsa051102.07410413
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.75835587
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.68698405
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.62969367
11Fatty acid elongation_Homo sapiens_hsa000621.57658615
12Protein export_Homo sapiens_hsa030601.57345240
13Rheumatoid arthritis_Homo sapiens_hsa053231.51213275
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48608235
15ECM-receptor interaction_Homo sapiens_hsa045121.47005954
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40837933
17Phagosome_Homo sapiens_hsa041451.38225180
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.36074611
19Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.34882216
20Dilated cardiomyopathy_Homo sapiens_hsa054141.34472986
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34375920
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.32928739
23Lysosome_Homo sapiens_hsa041421.28270493
24Histidine metabolism_Homo sapiens_hsa003401.21075905
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20113376
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.17944614
27Huntingtons disease_Homo sapiens_hsa050161.16475255
28Pyruvate metabolism_Homo sapiens_hsa006201.15918960
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15515288
30Dorso-ventral axis formation_Homo sapiens_hsa043201.14611245
31Sphingolipid metabolism_Homo sapiens_hsa006001.13605998
32Circadian rhythm_Homo sapiens_hsa047101.12939276
33Cardiac muscle contraction_Homo sapiens_hsa042601.12519898
34Propanoate metabolism_Homo sapiens_hsa006401.10985265
35Salivary secretion_Homo sapiens_hsa049701.10326956
36Adipocytokine signaling pathway_Homo sapiens_hsa049201.09982098
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08392314
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07804579
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07346721
40Nitrogen metabolism_Homo sapiens_hsa009101.04635842
41Serotonergic synapse_Homo sapiens_hsa047261.01765691
42Focal adhesion_Homo sapiens_hsa045100.99626559
43Gastric acid secretion_Homo sapiens_hsa049710.97396415
44Fat digestion and absorption_Homo sapiens_hsa049750.96507627
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95948547
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.95813651
47Mineral absorption_Homo sapiens_hsa049780.94693138
48Olfactory transduction_Homo sapiens_hsa047400.94107023
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93970579
50Long-term depression_Homo sapiens_hsa047300.91141071
51Renin-angiotensin system_Homo sapiens_hsa046140.90894182
52Renin secretion_Homo sapiens_hsa049240.90558909
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89813309
54Dopaminergic synapse_Homo sapiens_hsa047280.89547437
55Insulin resistance_Homo sapiens_hsa049310.89264079
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88579343
57Phenylalanine metabolism_Homo sapiens_hsa003600.86159088
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.85105821
59Phototransduction_Homo sapiens_hsa047440.84623630
60Chemical carcinogenesis_Homo sapiens_hsa052040.84174157
61Tyrosine metabolism_Homo sapiens_hsa003500.82978136
62Fatty acid degradation_Homo sapiens_hsa000710.82689059
63Starch and sucrose metabolism_Homo sapiens_hsa005000.82473681
64Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82224222
65Glutathione metabolism_Homo sapiens_hsa004800.81919594
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.81855561
67Fatty acid metabolism_Homo sapiens_hsa012120.80817389
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.79892472
69Folate biosynthesis_Homo sapiens_hsa007900.79847273
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79798272
71Protein digestion and absorption_Homo sapiens_hsa049740.79080880
72Long-term potentiation_Homo sapiens_hsa047200.78857708
73Pancreatic secretion_Homo sapiens_hsa049720.76537883
74Steroid biosynthesis_Homo sapiens_hsa001000.76113071
75Pertussis_Homo sapiens_hsa051330.75781306
76Circadian entrainment_Homo sapiens_hsa047130.75499272
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75121638
78Amphetamine addiction_Homo sapiens_hsa050310.74972181
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74360112
80Peroxisome_Homo sapiens_hsa041460.73709312
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72243985
82GABAergic synapse_Homo sapiens_hsa047270.72227546
83Fatty acid biosynthesis_Homo sapiens_hsa000610.71129912
84Cholinergic synapse_Homo sapiens_hsa047250.70977929
85Thyroid hormone synthesis_Homo sapiens_hsa049180.67725107
86Insulin secretion_Homo sapiens_hsa049110.67088980
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.66700235
88Type II diabetes mellitus_Homo sapiens_hsa049300.66580507
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66259086
90GnRH signaling pathway_Homo sapiens_hsa049120.65477630
91Salmonella infection_Homo sapiens_hsa051320.65434698
92cAMP signaling pathway_Homo sapiens_hsa040240.64390050
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.64245175
94PPAR signaling pathway_Homo sapiens_hsa033200.63772239
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62720372
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61896705
97Bile secretion_Homo sapiens_hsa049760.61779736
98Ovarian steroidogenesis_Homo sapiens_hsa049130.59973727
99Gap junction_Homo sapiens_hsa045400.59475277
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.59369601
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58893936
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58845319
103Butanoate metabolism_Homo sapiens_hsa006500.58444516
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.57106666
105Glutamatergic synapse_Homo sapiens_hsa047240.56674063
106Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55895239
107Galactose metabolism_Homo sapiens_hsa000520.55693581
108Complement and coagulation cascades_Homo sapiens_hsa046100.55051652
109Proteasome_Homo sapiens_hsa030500.54606626
110Cocaine addiction_Homo sapiens_hsa050300.54343571
111Amoebiasis_Homo sapiens_hsa051460.53928645
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.53664151
113Staphylococcus aureus infection_Homo sapiens_hsa051500.53263909
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52734420
115Taste transduction_Homo sapiens_hsa047420.52127778
116Malaria_Homo sapiens_hsa051440.51916070
117Arachidonic acid metabolism_Homo sapiens_hsa005900.50843881
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50779190
119Morphine addiction_Homo sapiens_hsa050320.49646712
120Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.49299751
121Axon guidance_Homo sapiens_hsa043600.48962313
122Tight junction_Homo sapiens_hsa045300.48941567
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48600586
124Shigellosis_Homo sapiens_hsa051310.48550435
125Regulation of autophagy_Homo sapiens_hsa041400.48245943
126Tryptophan metabolism_Homo sapiens_hsa003800.47151237
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47008780
128Proteoglycans in cancer_Homo sapiens_hsa052050.46610745
129Oxytocin signaling pathway_Homo sapiens_hsa049210.46531789
130Sulfur relay system_Homo sapiens_hsa041220.46038010
131* Endocytosis_Homo sapiens_hsa041440.45072522
132Other glycan degradation_Homo sapiens_hsa005110.44947231
133Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.43495478
134Glycerolipid metabolism_Homo sapiens_hsa005610.42855067
135Vitamin B6 metabolism_Homo sapiens_hsa007500.40145970
136Calcium signaling pathway_Homo sapiens_hsa040200.39907289
137Arginine biosynthesis_Homo sapiens_hsa002200.38449581
138Platelet activation_Homo sapiens_hsa046110.38206525

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