CHML

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA topological change (GO:0006265)7.57682066
2regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00437.17391303
3positive regulation of hormone biosynthetic process (GO:0046886)6.19715826
4DNA unwinding involved in DNA replication (GO:0006268)5.42241097
5postsynaptic membrane organization (GO:0001941)5.19334607
6sister chromatid segregation (GO:0000819)5.00574382
7presynaptic membrane assembly (GO:0097105)4.90830648
8mitotic sister chromatid segregation (GO:0000070)4.70566831
9protein localization to kinetochore (GO:0034501)4.68860985
10regulation of centriole replication (GO:0046599)4.66035423
11mitotic chromosome condensation (GO:0007076)4.62939880
12DNA replication checkpoint (GO:0000076)4.55072285
13mRNA transcription from RNA polymerase II promoter (GO:0042789)4.52789932
14positive regulation of protein sumoylation (GO:0033235)4.46086165
15regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.45512208
16positive regulation of glycolytic process (GO:0045821)4.40650677
17pre-miRNA processing (GO:0031054)4.35043299
18protein localization to chromosome, centromeric region (GO:0071459)4.29045942
19DNA strand elongation involved in DNA replication (GO:0006271)4.27680194
20regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)4.20874001
21mitotic nuclear envelope disassembly (GO:0007077)4.17930789
22DNA strand elongation (GO:0022616)4.13190781
23protein heterotetramerization (GO:0051290)4.11828244
24DNA replication initiation (GO:0006270)4.05477439
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.96361707
26nuclear envelope disassembly (GO:0051081)3.95902485
27membrane disassembly (GO:0030397)3.95902485
28regulation of centrosome cycle (GO:0046605)3.94702665
29positive regulation of hormone metabolic process (GO:0032352)3.94100382
30DNA duplex unwinding (GO:0032508)3.93919360
31meiotic chromosome segregation (GO:0045132)3.93610812
32regulation of RNA export from nucleus (GO:0046831)3.86575348
33positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.84942799
34mitotic sister chromatid cohesion (GO:0007064)3.83405961
35DNA geometric change (GO:0032392)3.83100221
36heterochromatin organization (GO:0070828)3.82647193
37chromatin remodeling at centromere (GO:0031055)3.79958768
38regulation of translational fidelity (GO:0006450)3.76000335
39histone H3-K9 demethylation (GO:0033169)3.74894713
40mRNA transcription (GO:0009299)3.72621664
41presynaptic membrane organization (GO:0097090)3.71106550
42regulation of centrosome duplication (GO:0010824)3.70402872
43CENP-A containing nucleosome assembly (GO:0034080)3.68403488
44double-strand break repair via nonhomologous end joining (GO:0006303)3.67893903
45non-recombinational repair (GO:0000726)3.67893903
46telomere maintenance via semi-conservative replication (GO:0032201)3.65084878
47mitotic metaphase plate congression (GO:0007080)3.61753639
48regulation of histone H3-K9 methylation (GO:0051570)3.61611787
49paraxial mesoderm development (GO:0048339)3.61032324
50kinetochore organization (GO:0051383)3.51677505
51mitotic recombination (GO:0006312)3.47764898
52regulation of chromosome segregation (GO:0051983)3.47365475
53metaphase plate congression (GO:0051310)3.47319172
54nuclear pore organization (GO:0006999)3.44218434
55histone H3-K9 methylation (GO:0051567)3.42953613
56ribosome assembly (GO:0042255)3.41932684
57DNA conformation change (GO:0071103)3.39925098
58telomere maintenance via recombination (GO:0000722)3.37755215
59regulation of mitotic spindle organization (GO:0060236)3.37574692
60establishment of integrated proviral latency (GO:0075713)3.36943096
61negative regulation of chromosome segregation (GO:0051985)3.35205821
62protein complex localization (GO:0031503)3.34101621
63DNA replication-independent nucleosome assembly (GO:0006336)3.31993447
64DNA replication-independent nucleosome organization (GO:0034724)3.31993447
65nuclear pore complex assembly (GO:0051292)3.30855591
66positive regulation of chromosome segregation (GO:0051984)3.30124831
67mitotic G2/M transition checkpoint (GO:0044818)3.29988191
68negative regulation of sister chromatid segregation (GO:0033046)3.29174534
69negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.29174534
70negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.29174534
71negative regulation of mitotic sister chromatid segregation (GO:0033048)3.29174534
72negative regulation of mitotic sister chromatid separation (GO:2000816)3.29174534
73regulation of DNA endoreduplication (GO:0032875)3.25992537
74spindle checkpoint (GO:0031577)3.25462255
75regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.24063432
76cellular protein complex localization (GO:0034629)3.23708405
77mitotic spindle checkpoint (GO:0071174)3.22847761
78positive regulation of erythrocyte differentiation (GO:0045648)3.22440177
79chromosome segregation (GO:0007059)3.21913253
80histone exchange (GO:0043486)3.20928249
81regulation of sister chromatid segregation (GO:0033045)3.18757239
82regulation of mitotic sister chromatid separation (GO:0010965)3.18757239
83regulation of mitotic sister chromatid segregation (GO:0033047)3.18757239
84somatic hypermutation of immunoglobulin genes (GO:0016446)3.18611872
85somatic diversification of immune receptors via somatic mutation (GO:0002566)3.18611872
86regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.18600581
87regulation of mitotic metaphase/anaphase transition (GO:0030071)3.18600581
88chromosome condensation (GO:0030261)3.17963447
89negative regulation of DNA repair (GO:0045738)3.17165728
90chromatin assembly or disassembly (GO:0006333)3.15552175
91mitotic spindle assembly checkpoint (GO:0007094)3.15485779
92cytoplasmic mRNA processing body assembly (GO:0033962)3.14118946
93DNA strand renaturation (GO:0000733)3.11884531
94spindle assembly checkpoint (GO:0071173)3.11180162
95chromatin assembly (GO:0031497)3.07422899
96regulation of nucleobase-containing compound transport (GO:0032239)3.07321659
97purine nucleobase biosynthetic process (GO:0009113)3.06722549
98nucleobase biosynthetic process (GO:0046112)3.05663112
99ATP-dependent chromatin remodeling (GO:0043044)3.05416701
100regulation of sister chromatid cohesion (GO:0007063)3.00840319
101negative regulation of histone methylation (GO:0031061)2.99715514
102formation of translation preinitiation complex (GO:0001731)2.98508152
103regulation of spindle organization (GO:0090224)2.97917876
104IMP biosynthetic process (GO:0006188)2.96042619
105microtubule depolymerization (GO:0007019)2.95986030
106DNA replication-dependent nucleosome assembly (GO:0006335)2.95132895
107DNA replication-dependent nucleosome organization (GO:0034723)2.95132895
108metallo-sulfur cluster assembly (GO:0031163)2.95092114
109iron-sulfur cluster assembly (GO:0016226)2.95092114
110nuclear envelope organization (GO:0006998)2.94448131
111DNA packaging (GO:0006323)2.94344080
112regulation of DNA damage checkpoint (GO:2000001)2.94217114
113resolution of meiotic recombination intermediates (GO:0000712)2.93919745
114folic acid-containing compound biosynthetic process (GO:0009396)2.92510243
115ganglion development (GO:0061548)2.92255784
116regulation of protein sumoylation (GO:0033233)2.92040516
117mRNA transport (GO:0051028)2.92004078
118establishment of chromosome localization (GO:0051303)2.91805754
119N-glycan processing (GO:0006491)2.90807568
120protein localization to chromosome (GO:0034502)2.89722735
121monoubiquitinated protein deubiquitination (GO:0035520)2.87513098
122metanephric mesenchyme development (GO:0072075)2.87162737
123embryonic placenta development (GO:0001892)2.86660349
124negative regulation of translation, ncRNA-mediated (GO:0040033)2.81639213
125regulation of translation, ncRNA-mediated (GO:0045974)2.81639213
126negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.81639213
127positive regulation vascular endothelial growth factor production (GO:0010575)2.81130288
128response to pheromone (GO:0019236)2.80428539
129regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78649997
130regulation of germinal center formation (GO:0002634)2.77768601
131positive regulation of DNA-dependent DNA replication (GO:2000105)2.77712444
132negative regulation of DNA-dependent DNA replication (GO:2000104)2.77300617
133interkinetic nuclear migration (GO:0022027)2.75560451
134DNA synthesis involved in DNA repair (GO:0000731)2.71751178
135negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.70387136
136dendritic cell chemotaxis (GO:0002407)2.67267996
137histone H3-K9 modification (GO:0061647)2.63633632
138germ cell migration (GO:0008354)2.63422570
139limb development (GO:0060173)2.62793244
140appendage development (GO:0048736)2.62793244
141negative regulation of smooth muscle cell differentiation (GO:0051151)2.59857827
142sister chromatid cohesion (GO:0007062)2.53967776
143peptidyl-lysine dimethylation (GO:0018027)2.50800322
144kinetochore assembly (GO:0051382)2.49983310
145pore complex assembly (GO:0046931)2.49858596
146proximal/distal pattern formation (GO:0009954)2.47835082
147regulation of vascular endothelial growth factor production (GO:0010574)2.46574466
148regulation of hormone biosynthetic process (GO:0046885)2.46292921
149kidney mesenchyme development (GO:0072074)2.41194022
150regulation of cell communication by electrical coupling (GO:0010649)2.40532394
151replicative senescence (GO:0090399)2.39227090
152histone demethylation (GO:0016577)2.38438806
153morphogenesis of an epithelial sheet (GO:0002011)2.37503287
154regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.37373167
155membrane assembly (GO:0071709)2.37211952
156suckling behavior (GO:0001967)2.36549772
157positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.36190928
158regulation of gonadotropin secretion (GO:0032276)2.35334964
159embryonic camera-type eye morphogenesis (GO:0048596)2.30966537
160histone mRNA catabolic process (GO:0071044)2.28927707
161generation of neurons (GO:0048699)2.27767870
162DNA catabolic process, exonucleolytic (GO:0000738)2.24056210
163axonal fasciculation (GO:0007413)2.20782374
164protein localization to cytoskeleton (GO:0044380)2.19314582
165protein demethylation (GO:0006482)2.15210624
166protein dealkylation (GO:0008214)2.15210624
167regulation of glycolytic process (GO:0006110)2.14635963
168positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.14534367
169positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.14534367
170positive regulation of mitotic sister chromatid separation (GO:1901970)2.14534367
171myoblast differentiation (GO:0045445)2.14434998
172type B pancreatic cell development (GO:0003323)2.13626758
173protein localization to microtubule cytoskeleton (GO:0072698)2.12340206
174negative regulation of striated muscle cell apoptotic process (GO:0010664)2.10141607
175definitive hemopoiesis (GO:0060216)2.10064290
176sequestering of extracellular ligand from receptor (GO:0035581)2.09645539
177signal peptide processing (GO:0006465)2.07375394
178translesion synthesis (GO:0019985)2.07084944
179dendritic cell migration (GO:0036336)2.07000778
180histone lysine demethylation (GO:0070076)2.04905410
181production of molecular mediator involved in inflammatory response (GO:0002532)2.04611788
182axon extension involved in axon guidance (GO:0048846)2.03261758
183neuron projection extension involved in neuron projection guidance (GO:1902284)2.03261758
184microtubule anchoring (GO:0034453)2.01077940
185regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.00956376
186iron ion import (GO:0097286)2.00907593
187auditory receptor cell differentiation (GO:0042491)1.99964449
188regulation of cardioblast proliferation (GO:0003264)1.99484648

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.93329875
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.88427921
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.38292297
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.31909429
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.53254652
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.36366400
7AR_21909140_ChIP-Seq_LNCAP_Human3.05377466
8* SALL1_21062744_ChIP-ChIP_HESCs_Human2.84967566
9EZH2_22144423_ChIP-Seq_EOC_Human2.77754874
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33914919
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.32391304
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29874551
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28045728
14KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.25594659
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24077641
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23740485
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.20185516
18ELK1_19687146_ChIP-ChIP_HELA_Human2.15330467
19YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.07543741
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.07183330
21EGR1_19374776_ChIP-ChIP_THP-1_Human2.04729019
22GBX2_23144817_ChIP-Seq_PC3_Human2.03776632
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97894683
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.91582837
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.89431065
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88865569
27NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84667993
28PCGF2_27294783_Chip-Seq_NPCs_Mouse1.82799129
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.80578177
30BP1_19119308_ChIP-ChIP_Hs578T_Human1.79035324
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78652380
32GATA1_22025678_ChIP-Seq_K562_Human1.76805405
33BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75710756
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.75330977
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.74318686
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71965754
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71511524
38PADI4_21655091_ChIP-ChIP_MCF-7_Human1.70821236
39* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70460625
40FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.67849553
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.66417241
42POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64264708
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64089532
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63461666
45* E2F1_18555785_Chip-Seq_ESCs_Mouse1.63294874
46* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62638056
47EWS_26573619_Chip-Seq_HEK293_Human1.59254183
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55625742
49SMAD4_21799915_ChIP-Seq_A2780_Human1.54919555
50CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.54421775
51XRN2_22483619_ChIP-Seq_HELA_Human1.54026469
52EST1_17652178_ChIP-ChIP_JURKAT_Human1.52348681
53P300_19829295_ChIP-Seq_ESCs_Human1.51974616
54TTF2_22483619_ChIP-Seq_HELA_Human1.51349681
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.50440180
56* NANOG_18555785_Chip-Seq_ESCs_Mouse1.49982485
57RNF2_27304074_Chip-Seq_NSC_Mouse1.48404671
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.47982094
59FLI1_27457419_Chip-Seq_LIVER_Mouse1.47299513
60FUS_26573619_Chip-Seq_HEK293_Human1.46191252
61MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45983134
62ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43682036
63IRF1_19129219_ChIP-ChIP_H3396_Human1.43585961
64* P53_22387025_ChIP-Seq_ESCs_Mouse1.42200021
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.40624434
66* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39575993
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38337892
68EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38192836
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.38038241
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.37814220
71CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.36221327
72* NMYC_18555785_Chip-Seq_ESCs_Mouse1.35279826
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34731161
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.34520147
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.33874175
76POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33777919
77TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33777919
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.33076599
79DCP1A_22483619_ChIP-Seq_HELA_Human1.32995738
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.32489625
81FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32443811
82SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.32331718
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31966018
84* CMYC_18555785_Chip-Seq_ESCs_Mouse1.31479112
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30404381
86GABP_17652178_ChIP-ChIP_JURKAT_Human1.27942159
87SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27596107
88TP53_16413492_ChIP-PET_HCT116_Human1.27404595
89FOXM1_23109430_ChIP-Seq_U2OS_Human1.26704750
90TCF4_23295773_ChIP-Seq_U87_Human1.26647881
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.26454811
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26304115
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.26129083
94AHR_22903824_ChIP-Seq_MCF-7_Human1.25935883
95* P300_18555785_Chip-Seq_ESCs_Mouse1.24500235
96TP53_18474530_ChIP-ChIP_U2OS_Human1.23835440
97RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.23637055
98KDM5A_27292631_Chip-Seq_BREAST_Human1.23275633
99SOX2_16153702_ChIP-ChIP_HESCs_Human1.21890962
100* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.21584748
101EZH2_27294783_Chip-Seq_NPCs_Mouse1.19018390
102STAT3_23295773_ChIP-Seq_U87_Human1.18148204
103E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18073317
104* STAT3_18555785_Chip-Seq_ESCs_Mouse1.17823462
105MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16953233
106CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16469233
107* OCT4_18555785_Chip-Seq_ESCs_Mouse1.16216002
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15838535
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15301527
110E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14901879
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14533124
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.14509084
113ZNF274_21170338_ChIP-Seq_K562_Hela1.12670113
114* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11115955
115STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10901683
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10900158
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10460252
118* SOX2_18555785_Chip-Seq_ESCs_Mouse1.10286063
119MYC_18940864_ChIP-ChIP_HL60_Human1.09288713
120FOXP3_21729870_ChIP-Seq_TREG_Human1.09266592
121GATA2_21666600_ChIP-Seq_HMVEC_Human1.08576341
122NANOG_16153702_ChIP-ChIP_HESCs_Human1.07582071
123* PU1_27457419_Chip-Seq_LIVER_Mouse1.07350733
124* ZFX_18555785_Chip-Seq_ESCs_Mouse1.06173249
125CHD1_26751641_Chip-Seq_LNCaP_Human1.05604498
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04400531
127IGF1R_20145208_ChIP-Seq_DFB_Human1.03744542
128NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03354683
129HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02711326
130* RUNX1_27457419_Chip-Seq_LIVER_Mouse1.02583252
131CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02388300
132YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01998460
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01177802
134E2F1_21310950_ChIP-Seq_MCF-7_Human1.00663396
135TAF15_26573619_Chip-Seq_HEK293_Human1.00588799
136* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99590134
137VDR_23849224_ChIP-Seq_CD4+_Human0.98081278
138BRD4_25478319_ChIP-Seq_HGPS_Human0.97033703
139TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96514088
140RUNX2_22187159_ChIP-Seq_PCA_Human0.95548946
141TCF4_18268006_ChIP-ChIP_LS174T_Human0.94613486
142KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93900359
143KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93728116
144RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93548808
145SOX17_20123909_ChIP-Seq_XEN_Mouse0.93321666
146SOX2_21211035_ChIP-Seq_LN229_Gbm0.91832204
147ER_23166858_ChIP-Seq_MCF-7_Human0.91715057
148CBX2_27304074_Chip-Seq_ESCs_Mouse0.90772662
149* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.90678503
150NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90530086
151ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.89988839
152JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89943327
153NANOG_21062744_ChIP-ChIP_HESCs_Human0.89075816
154SOX2_18555785_ChIP-Seq_MESCs_Mouse0.88113451
155SOX9_26525672_Chip-Seq_HEART_Mouse0.87785176
156HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.87375105
157* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85438216
158GABP_19822575_ChIP-Seq_HepG2_Human0.83517494
159PKCTHETA_26484144_Chip-Seq_BREAST_Human0.83399066
160STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83157233
161ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.82939332
162TFEB_21752829_ChIP-Seq_HELA_Human0.82234784
163POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81990183
164* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81898952
165ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.78476549
166CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78184025
167DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78058847
168POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76244159
169ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73369904
170DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.73334338
171RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.72876107
172FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.72275616
173GATA1_26923725_Chip-Seq_HPCs_Mouse0.69906269
174EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.65372424
175FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.65248285
176MYC_22102868_ChIP-Seq_BL_Human0.64867179

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog3.69786443
2MP0003787_abnormal_imprinting3.49038991
3MP0000569_abnormal_digit_pigmentation3.44076223
4MP0003183_abnormal_peptide_metabolism3.02748536
5MP0001986_abnormal_taste_sensitivity2.84566750
6MP0009697_abnormal_copulation2.79859107
7MP0008877_abnormal_DNA_methylation2.46416354
8MP0003121_genomic_imprinting2.14044707
9MP0003122_maternal_imprinting2.06239021
10MP0003890_abnormal_embryonic-extraembry2.00346631
11MP0001188_hyperpigmentation1.95909840
12MP0010307_abnormal_tumor_latency1.95733620
13MP0001177_atelectasis1.95068490
14MP0000579_abnormal_nail_morphology1.93428148
15MP0005171_absent_coat_pigmentation1.92712528
16MP0000350_abnormal_cell_proliferation1.92144001
17MP0001730_embryonic_growth_arrest1.89174050
18MP0001672_abnormal_embryogenesis/_devel1.81707465
19MP0005380_embryogenesis_phenotype1.81707465
20MP0003828_pulmonary_edema1.79783742
21MP0001697_abnormal_embryo_size1.77957930
22MP0002084_abnormal_developmental_patter1.76800717
23MP0002877_abnormal_melanocyte_morpholog1.72044626
24MP0002638_abnormal_pupillary_reflex1.68416676
25MP0008995_early_reproductive_senescence1.68185711
26MP0003984_embryonic_growth_retardation1.67625449
27MP0003123_paternal_imprinting1.66737820
28MP0002088_abnormal_embryonic_growth/wei1.63015822
29MP0009672_abnormal_birth_weight1.62922314
30MP0002697_abnormal_eye_size1.62642834
31MP0002085_abnormal_embryonic_tissue1.59073492
32MP0003941_abnormal_skin_development1.55533164
33MP0002876_abnormal_thyroid_physiology1.55289184
34MP0010094_abnormal_chromosome_stability1.52703648
35MP0004145_abnormal_muscle_electrophysio1.51680301
36MP0005387_immune_system_phenotype1.51547362
37MP0001790_abnormal_immune_system1.51547362
38MP0002751_abnormal_autonomic_nervous1.50364125
39MP0002080_prenatal_lethality1.48822285
40MP0000516_abnormal_urinary_system1.48567296
41MP0005367_renal/urinary_system_phenotyp1.48567296
42MP0005646_abnormal_pituitary_gland1.48126016
43MP0002009_preneoplasia1.44930154
44MP0001293_anophthalmia1.44204937
45MP0002086_abnormal_extraembryonic_tissu1.40541096
46MP0004808_abnormal_hematopoietic_stem1.39428357
47MP0003718_maternal_effect1.37828792
48MP0003786_premature_aging1.35162166
49MP0000537_abnormal_urethra_morphology1.34922471
50MP0000428_abnormal_craniofacial_morphol1.31985348
51MP0001286_abnormal_eye_development1.28290576
52MP0008007_abnormal_cellular_replicative1.27850818
53MP0009703_decreased_birth_body1.27721185
54MP0003942_abnormal_urinary_system1.27244553
55MP0004272_abnormal_basement_membrane1.23648010
56MP0003937_abnormal_limbs/digits/tail_de1.23317659
57MP0001299_abnormal_eye_distance/1.22209172
58MP0001881_abnormal_mammary_gland1.19866877
59MP0010352_gastrointestinal_tract_polyps1.19431571
60MP0003705_abnormal_hypodermis_morpholog1.19307136
61MP0000627_abnormal_mammary_gland1.18216914
62MP0003221_abnormal_cardiomyocyte_apopto1.18203273
63MP0008932_abnormal_embryonic_tissue1.16282846
64MP0009379_abnormal_foot_pigmentation1.14878347
65MP0005645_abnormal_hypothalamus_physiol1.14321194
66MP0002092_abnormal_eye_morphology1.14113600
67MP0002133_abnormal_respiratory_system1.11246829
68MP0005388_respiratory_system_phenotype1.11246829
69MP0000432_abnormal_head_morphology1.10053873
70MP0003950_abnormal_plasma_membrane1.09723598
71MP0002095_abnormal_skin_pigmentation1.07215651
72MP0000313_abnormal_cell_death1.06993320
73MP0000049_abnormal_middle_ear1.06250631
74MP0003861_abnormal_nervous_system1.05486261
75MP0003693_abnormal_embryo_hatching1.05356071
76MP0010386_abnormal_urinary_bladder1.04522949
77MP0000566_synostosis1.04459931
78MP0002396_abnormal_hematopoietic_system1.04003092
79MP0005187_abnormal_penis_morphology1.01253895
80MP0008057_abnormal_DNA_replication1.00613771
81MP0002111_abnormal_tail_morphology1.00066960
82MP0001879_abnormal_lymphatic_vessel0.99150581
83MP0003091_abnormal_cell_migration0.99073654
84MP0005076_abnormal_cell_differentiation0.98597713
85MP0000647_abnormal_sebaceous_gland0.97278823
86MP0002098_abnormal_vibrissa_morphology0.96629782
87MP0004185_abnormal_adipocyte_glucose0.93970728
88MP0005623_abnormal_meninges_morphology0.93368283
89MP0003111_abnormal_nucleus_morphology0.92176907
90MP0002210_abnormal_sex_determination0.91605512
91MP0008058_abnormal_DNA_repair0.91521085
92MP0001270_distended_abdomen0.90986051
93MP0004197_abnormal_fetal_growth/weight/0.90548181
94MP0008789_abnormal_olfactory_epithelium0.89337138
95MP0002006_tumorigenesis0.88001237
96MP0003936_abnormal_reproductive_system0.87956389
97MP0003315_abnormal_perineum_morphology0.87594490
98MP0004147_increased_porphyrin_level0.87520577
99MP0002277_abnormal_respiratory_mucosa0.86956660
100MP0003300_gastrointestinal_ulcer0.84958340
101MP0003119_abnormal_digestive_system0.84920676
102MP0001919_abnormal_reproductive_system0.84856152
103MP0002254_reproductive_system_inflammat0.84479449
104MP0002928_abnormal_bile_duct0.83933587
105MP0003935_abnormal_craniofacial_develop0.82920896
106MP0003385_abnormal_body_wall0.82819714
107MP0001929_abnormal_gametogenesis0.82640754
108MP0001661_extended_life_span0.82584486
109MP0004084_abnormal_cardiac_muscle0.81024725
110MP0010030_abnormal_orbit_morphology0.80819059
111MP0002177_abnormal_outer_ear0.80614402
112MP0003656_abnormal_erythrocyte_physiolo0.80244448
113MP0000358_abnormal_cell_content/0.79400919
114MP0008770_decreased_survivor_rate0.78786689
115MP0000613_abnormal_salivary_gland0.78579421
116MP0000631_abnormal_neuroendocrine_gland0.77335055
117MP0010234_abnormal_vibrissa_follicle0.76839365
118MP0001145_abnormal_male_reproductive0.76405927
119MP0002233_abnormal_nose_morphology0.74788332
120MP0005384_cellular_phenotype0.74763156
121MP0002938_white_spotting0.73250948
122MP0003077_abnormal_cell_cycle0.72963049
123MP0002109_abnormal_limb_morphology0.72942852
124MP0005621_abnormal_cell_physiology0.72591775
125MP0003567_abnormal_fetal_cardiomyocyte0.72202687
126MP0003453_abnormal_keratinocyte_physiol0.72013881
127MP0001119_abnormal_female_reproductive0.71717389
128MP0006035_abnormal_mitochondrial_morpho0.71164317
129MP0004510_myositis0.70740554
130MP0001175_abnormal_lung_morphology0.70035915
131MP0003136_yellow_coat_color0.69422089
132MP0003566_abnormal_cell_adhesion0.69126997
133MP0005389_reproductive_system_phenotype0.68738791
134MP0005391_vision/eye_phenotype0.68599077
135MP0002925_abnormal_cardiovascular_devel0.68313479
136MP0000653_abnormal_sex_gland0.68301115
137MP0006292_abnormal_olfactory_placode0.67986592
138MP0004233_abnormal_muscle_weight0.67594883
139MP0000372_irregular_coat_pigmentation0.67582643
140MP0002736_abnormal_nociception_after0.67294768
141MP0002735_abnormal_chemical_nociception0.67255227
142MP0001784_abnormal_fluid_regulation0.66990491
143MP0009053_abnormal_anal_canal0.66828706
144MP0003115_abnormal_respiratory_system0.66807659
145MP0000538_abnormal_urinary_bladder0.66769199
146MP0003755_abnormal_palate_morphology0.66680577
147MP0002081_perinatal_lethality0.66579231
148MP0003699_abnormal_female_reproductive0.66457002
149MP0002108_abnormal_muscle_morphology0.65943110
150MP0002019_abnormal_tumor_incidence0.65716185
151MP0001835_abnormal_antigen_presentation0.65248316
152MP0003943_abnormal_hepatobiliary_system0.65210816
153MP0002114_abnormal_axial_skeleton0.63472746
154MP0001186_pigmentation_phenotype0.63110817
155MP0010678_abnormal_skin_adnexa0.62671666
156MP0001915_intracranial_hemorrhage0.61450850
157MP0002184_abnormal_innervation0.61327527
158MP0003698_abnormal_male_reproductive0.60643606
159MP0000383_abnormal_hair_follicle0.59776687
160MP0005083_abnormal_biliary_tract0.58834274

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.29921776
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.28932110
3Birth length less than 3rd percentile (HP:0003561)4.06302375
4Exostoses (HP:0100777)3.58570328
5Craniofacial hyperostosis (HP:0004493)3.50455709
6Asymmetry of the thorax (HP:0001555)3.46222520
7Cortical dysplasia (HP:0002539)3.38911485
8Tubulointerstitial nephritis (HP:0001970)3.27942675
9Cutaneous finger syndactyly (HP:0010554)3.22808262
10Cranial hyperostosis (HP:0004437)3.21570986
11Increased nuchal translucency (HP:0010880)3.00937797
12Volvulus (HP:0002580)2.93136289
13Abnormality of the nasal septum (HP:0000419)2.80903102
14Upper limb muscle weakness (HP:0003484)2.67202174
15Ectopic kidney (HP:0000086)2.66354658
16Cutaneous syndactyly (HP:0012725)2.63566933
17Hypothermia (HP:0002045)2.58788136
18Small intestinal stenosis (HP:0012848)2.56916204
19Duodenal stenosis (HP:0100867)2.56916204
20Nephroblastoma (Wilms tumor) (HP:0002667)2.55194609
21Abnormal lung lobation (HP:0002101)2.52412553
22Myelodysplasia (HP:0002863)2.50561815
23Termporal pattern (HP:0011008)2.45277741
24Insidious onset (HP:0003587)2.45277741
2511 pairs of ribs (HP:0000878)2.44960479
26Aplasia cutis congenita (HP:0001057)2.44950363
27Sandal gap (HP:0001852)2.44425529
28Embryonal renal neoplasm (HP:0011794)2.43510695
29Renal hypoplasia (HP:0000089)2.41955516
30Split foot (HP:0001839)2.41927708
31Rhabdomyosarcoma (HP:0002859)2.40316151
32Papillary thyroid carcinoma (HP:0002895)2.39774158
33Febrile seizures (HP:0002373)2.37892283
34Flared iliac wings (HP:0002869)2.37506786
35Cafe-au-lait spot (HP:0000957)2.35777967
36Ankyloglossia (HP:0010296)2.33359825
37Spinal cord compression (HP:0002176)2.31404729
38Deep philtrum (HP:0002002)2.31245572
39Overlapping toe (HP:0001845)2.31194838
40Dysmetric saccades (HP:0000641)2.30648756
41Ependymoma (HP:0002888)2.25419963
42Aortic regurgitation (HP:0001659)2.25102932
43Long foot (HP:0001833)2.22899601
44Abnormality of chromosome stability (HP:0003220)2.22265142
45Macroorchidism (HP:0000053)2.21829845
46Abnormality of the duodenum (HP:0002246)2.21777707
47Medulloblastoma (HP:0002885)2.21500522
48Meckel diverticulum (HP:0002245)2.19864138
49Glioma (HP:0009733)2.18918836
50Astrocytoma (HP:0009592)2.17792792
51Abnormality of the astrocytes (HP:0100707)2.17792792
52Abnormality of DNA repair (HP:0003254)2.17560468
53Missing ribs (HP:0000921)2.15997214
54Stomach cancer (HP:0012126)2.11930593
55Hepatoblastoma (HP:0002884)2.11858689
56Absent radius (HP:0003974)2.11198379
57Thyroid carcinoma (HP:0002890)2.10763017
58Sloping forehead (HP:0000340)2.09395752
59Aplasia/Hypoplasia of the sternum (HP:0006714)2.08747978
60Homocystinuria (HP:0002156)2.07677523
61Abnormality of homocysteine metabolism (HP:0010919)2.07677523
62Carpal synostosis (HP:0009702)2.06614375
63Aplasia/Hypoplasia of the uvula (HP:0010293)2.05560435
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.05228129
65Absent frontal sinuses (HP:0002688)2.04518614
66Partial agenesis of the corpus callosum (HP:0001338)2.04401222
67Abnormality of cochlea (HP:0000375)2.04234067
68Synostosis of carpal bones (HP:0005048)2.02935049
69Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.02316775
70Relative macrocephaly (HP:0004482)1.99299076
71High anterior hairline (HP:0009890)1.98604915
72Abnormality of the ileum (HP:0001549)1.98397168
73Rectal prolapse (HP:0002035)1.98266767
74Lip pit (HP:0100267)1.97337424
75Bell-shaped thorax (HP:0001591)1.97140528
76Absent forearm bone (HP:0003953)1.95371478
77Aplasia involving forearm bones (HP:0009822)1.95371478
78Flat capital femoral epiphysis (HP:0003370)1.94639697
79Obsessive-compulsive behavior (HP:0000722)1.93611320
80Colon cancer (HP:0003003)1.91935574
81Reticulocytopenia (HP:0001896)1.91354663
82Abnormality of the labia minora (HP:0012880)1.90035916
83Abnormality of the parathyroid morphology (HP:0011766)1.87869661
84Abnormality of the renal collecting system (HP:0004742)1.87631899
85Selective tooth agenesis (HP:0001592)1.87227727
86Alveolar cell carcinoma (HP:0006519)1.85952538
87Dislocated radial head (HP:0003083)1.85858831
88Morphological abnormality of the middle ear (HP:0008609)1.85485255
89Increased number of teeth (HP:0011069)1.84250008
90Choanal atresia (HP:0000453)1.84136804
91Deviation of the thumb (HP:0009603)1.83762294
92Neoplasm of the tracheobronchial system (HP:0100552)1.83555142
93Duplicated collecting system (HP:0000081)1.83172960
94Neoplasm of the colon (HP:0100273)1.83043417
95Absent eyebrow (HP:0002223)1.82476640
96Prostate neoplasm (HP:0100787)1.81709071
97Limb dystonia (HP:0002451)1.81414410
98Abnormality of the frontal sinuses (HP:0002687)1.81388833
99Abnormality of the calcaneus (HP:0008364)1.80915253
100Proximal placement of thumb (HP:0009623)1.80304871
101Abnormality of the radial head (HP:0003995)1.79636738
102Arteriovenous malformation (HP:0100026)1.79210828
103Diastasis recti (HP:0001540)1.78734010
104Spastic diplegia (HP:0001264)1.77975741
105Transitional cell carcinoma of the bladder (HP:0006740)1.76993620
106Malignant gastrointestinal tract tumors (HP:0006749)1.76954950
107Gastrointestinal carcinoma (HP:0002672)1.76954950
108Progressive sensorineural hearing impairment (HP:0000408)1.76593224
109Xerostomia (HP:0000217)1.76266279
110Abnormality of chromosome segregation (HP:0002916)1.75476554
111Clubbing of toes (HP:0100760)1.75290158
112Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73275333
113Abnormal number of incisors (HP:0011064)1.73144668
114Neoplasm of the adrenal cortex (HP:0100641)1.72980298
115Duplication of thumb phalanx (HP:0009942)1.72390606
116Primary atrial arrhythmia (HP:0001692)1.72161064
117Neoplasm of the small intestine (HP:0100833)1.71906279
118Prominent forehead (HP:0011220)1.71803251
119Abnormality of the preputium (HP:0100587)1.70327422
120Supernumerary ribs (HP:0005815)1.69542623
121Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.68978157
122Acute myeloid leukemia (HP:0004808)1.68592175
123Abnormality of oral frenula (HP:0000190)1.68022824
124Congenital sensorineural hearing impairment (HP:0008527)1.67993267
125Abnormality of incisor morphology (HP:0011063)1.66774967
126Abnormal cortical bone morphology (HP:0003103)1.66716529
127Cystic hygroma (HP:0000476)1.66609868
128Progressive external ophthalmoplegia (HP:0000590)1.65852441
129Abnormality of the right ventricle (HP:0001707)1.65530497
130Spinal cord lesions (HP:0100561)1.64943756
131Syringomyelia (HP:0003396)1.64943756
132Triphalangeal thumb (HP:0001199)1.64819123
133Heterotopia (HP:0002282)1.64752713
134Synostosis involving bones of the hand (HP:0004278)1.64541518
135Multiple enchondromatosis (HP:0005701)1.64007227
136Long nose (HP:0003189)1.63944826
137Gingivitis (HP:0000230)1.63725285
138Attention deficit hyperactivity disorder (HP:0007018)1.62725415
139Convex nasal ridge (HP:0000444)1.62154105
140Atrial fibrillation (HP:0005110)1.61880246
141Hyperthyroidism (HP:0000836)1.61789733
142Thick eyebrow (HP:0000574)1.61621221
143Meningioma (HP:0002858)1.61461971
144Protruding tongue (HP:0010808)1.60821803
145Abnormality of the carotid arteries (HP:0005344)1.60380950
146Abnormal auditory evoked potentials (HP:0006958)1.60334769
147Bradycardia (HP:0001662)1.59140882
148Osteomalacia (HP:0002749)1.58277355
149Embryonal neoplasm (HP:0002898)1.57735333
150Abnormality of the wing of the ilium (HP:0011867)1.57549260
151Facial cleft (HP:0002006)1.57533240
152Fibular aplasia (HP:0002990)1.57024823
153Inappropriate behavior (HP:0000719)1.56718453
154Biliary tract neoplasm (HP:0100574)1.56032774
155Hematochezia (HP:0002573)1.55654231
156Leiomyosarcoma (HP:0100243)1.55469531
157Uterine leiomyosarcoma (HP:0002891)1.55469531
158Prominent nose (HP:0000448)1.55303210
159Submucous cleft hard palate (HP:0000176)1.55046228
160Morphological abnormality of the inner ear (HP:0011390)1.54842652
161Generalized hypopigmentation of hair (HP:0011358)1.54833523
162Short philtrum (HP:0000322)1.54721226
163Skull defect (HP:0001362)1.54313726
164Bladder neoplasm (HP:0009725)1.53647405
165Bladder carcinoma (HP:0002862)1.53647405
166Long clavicles (HP:0000890)1.53564929
167Patellar aplasia (HP:0006443)1.52989360
168Atresia of the external auditory canal (HP:0000413)1.50527875
169Breast hypoplasia (HP:0003187)1.50337163
170Acute lymphatic leukemia (HP:0006721)1.49418071
171Cerebellar dysplasia (HP:0007033)1.49355646
172Uterine neoplasm (HP:0010784)1.47551903

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTK3.40738956
2ERBB33.39084373
3STK243.23297013
4FRK3.23116681
5NTRK33.22096555
6ZAK3.19657022
7LATS13.11460214
8SRPK12.96579659
9WEE12.69160316
10MAP3K142.65091865
11PBK2.64316319
12TSSK62.53895113
13MKNK22.52144522
14EIF2AK12.48257990
15BUB12.28351086
16PLK42.26799108
17BRD42.21939527
18CASK2.14470804
19EEF2K2.03066692
20NEK11.94957705
21MKNK11.93421812
22CDK121.87434236
23INSRR1.73042214
24CDC71.71698293
25NEK21.67334491
26MARK11.63637395
27TRPM71.58532019
28SGK21.56380859
29EIF2AK31.56207593
30LATS21.56117513
31PNCK1.54997280
32AKT31.54365950
33EIF2AK21.47683404
34FGFR31.42805170
35RPS6KB21.41627915
36CDK81.38544481
37EPHB21.36855204
38PDK21.28741668
39TNIK1.28640444
40BMPR1B1.28064897
41TIE11.25095604
42WNK11.21326358
43CDC42BPA1.21090705
44MAP3K131.20682040
45GRK11.19141689
46YES11.16046943
47CAMK1G1.15453957
48NEK61.14610959
49NLK1.14202098
50BRSK11.11990454
51ICK1.11529297
52RPS6KA41.08421539
53TAF11.05496752
54CHUK1.04438861
55PLK31.02163834
56ATM1.01724348
57MST1R0.98632043
58SGK30.98172395
59SGK4940.97863872
60SGK2230.97863872
61CDK30.95981204
62IRAK40.94634216
63CDK90.94004478
64MAP3K60.93551879
65MAP3K40.93490050
66CHEK20.90612556
67SGK10.90042606
68CDK70.89948701
69MAP2K70.89627130
70BRSK20.87560835
71TGFBR10.85863415
72CDK60.85371939
73ATR0.83953447
74AURKB0.83915710
75BMPR20.81566964
76TEC0.79971244
77SIK30.79086144
78STK38L0.78416083
79LMTK20.78237039
80BCR0.77572990
81PRKCI0.77113404
82CCNB10.76802845
83DYRK30.75742993
84STK40.72657720
85CSNK1E0.72336351
86PASK0.71671000
87MATK0.71087580
88MAPK130.68951152
89MTOR0.66655587
90RAF10.66557695
91PLK20.65757119
92MET0.64668895
93CHEK10.63665809
94MAP3K80.62778312
95KSR20.62632149
96PAK30.60903683
97ADRBK10.60494657
98PRKDC0.58790966
99IRAK20.57056161
100MAP3K20.56738151
101TLK10.56724594
102FGFR10.56507147
103CLK10.55704303
104PIM10.55577105
105DYRK20.54986784
106CDK40.54368782
107PRPF4B0.54115484
108MINK10.53389077
109PDGFRA0.51179154
110PTK60.50959848
111MAP3K100.48752481
112PRKCQ0.48564899
113BMX0.48512056
114CDK10.48502252
115PLK10.47865128
116MAPK140.47375799
117DYRK1A0.46131646
118SCYL20.46040138
119PRKCE0.45224721
120ALK0.43895175
121BRAF0.43849370
122AURKA0.43687227
123MAP2K10.43617802
124ERBB40.43254403
125WNK40.43042575
126TRIM280.41028678
127CSNK2A20.40512844
128AKT10.38043997
129VRK10.37326830
130RPS6KB10.36729170
131OBSCN0.36714731
132CAMK1D0.36515303
133MAPK100.36478530
134ACVR1B0.35888331
135PAK20.35807388
136KSR10.35754243
137MAPK80.35744554
138CAMKK10.35156158
139NUAK10.34453502
140CSNK1A1L0.34299543
141GSK3B0.34080227
142PRKG20.33994296
143CDK20.33088311
144STK30.33074897
145FER0.32876991
146MAP2K60.31637140
147STK390.31543998
148MST40.30250562
149MAP3K90.28981963

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.19768739
2Homologous recombination_Homo sapiens_hsa034402.60110857
3Fanconi anemia pathway_Homo sapiens_hsa034602.58135733
4Spliceosome_Homo sapiens_hsa030402.51642017
5One carbon pool by folate_Homo sapiens_hsa006702.43851292
6Base excision repair_Homo sapiens_hsa034101.87674695
7Basal transcription factors_Homo sapiens_hsa030221.73577192
8Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.72288373
9Selenocompound metabolism_Homo sapiens_hsa004501.63287518
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62231084
11NF-kappa B signaling pathway_Homo sapiens_hsa040641.40420740
12NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34094578
13Intestinal immune network for IgA production_Homo sapiens_hsa046721.33707821
14Cell cycle_Homo sapiens_hsa041101.33312184
15mRNA surveillance pathway_Homo sapiens_hsa030151.31784570
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.31693397
17Small cell lung cancer_Homo sapiens_hsa052221.26378091
18Endometrial cancer_Homo sapiens_hsa052131.25148954
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23976838
20RNA polymerase_Homo sapiens_hsa030201.23955758
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23696558
22Lysine degradation_Homo sapiens_hsa003101.23604221
23Biosynthesis of amino acids_Homo sapiens_hsa012301.21707520
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20391778
25Leishmaniasis_Homo sapiens_hsa051401.16332677
26Thyroid cancer_Homo sapiens_hsa052161.15106057
27Pyrimidine metabolism_Homo sapiens_hsa002401.13398667
28Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.13258333
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11921611
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.10843368
31Nucleotide excision repair_Homo sapiens_hsa034201.09884865
32Pyruvate metabolism_Homo sapiens_hsa006201.09475874
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08531105
34MicroRNAs in cancer_Homo sapiens_hsa052061.07705166
35Non-homologous end-joining_Homo sapiens_hsa034501.04547651
36Adherens junction_Homo sapiens_hsa045201.03939458
37Mismatch repair_Homo sapiens_hsa034301.01396236
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.95012130
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.94872298
40Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94820218
41Central carbon metabolism in cancer_Homo sapiens_hsa052300.94287787
42Prostate cancer_Homo sapiens_hsa052150.93888358
43Melanoma_Homo sapiens_hsa052180.93642927
44Hippo signaling pathway_Homo sapiens_hsa043900.92299959
45Osteoclast differentiation_Homo sapiens_hsa043800.91893983
46Toll-like receptor signaling pathway_Homo sapiens_hsa046200.91339748
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90846074
48Viral carcinogenesis_Homo sapiens_hsa052030.89901012
49FoxO signaling pathway_Homo sapiens_hsa040680.89397356
50Prolactin signaling pathway_Homo sapiens_hsa049170.89175213
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88763816
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88742219
53Toxoplasmosis_Homo sapiens_hsa051450.88515350
54Dilated cardiomyopathy_Homo sapiens_hsa054140.88453862
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.88173857
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87553505
57Colorectal cancer_Homo sapiens_hsa052100.87316798
58Purine metabolism_Homo sapiens_hsa002300.86329617
59Systemic lupus erythematosus_Homo sapiens_hsa053220.85054205
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83884856
61ECM-receptor interaction_Homo sapiens_hsa045120.83338075
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83143776
63Chronic myeloid leukemia_Homo sapiens_hsa052200.82300407
64Hematopoietic cell lineage_Homo sapiens_hsa046400.80971943
65Pancreatic cancer_Homo sapiens_hsa052120.80939714
66Type I diabetes mellitus_Homo sapiens_hsa049400.80138203
67Non-small cell lung cancer_Homo sapiens_hsa052230.79892414
68Taste transduction_Homo sapiens_hsa047420.77910348
69Renal cell carcinoma_Homo sapiens_hsa052110.77729436
70Focal adhesion_Homo sapiens_hsa045100.77698606
71Salmonella infection_Homo sapiens_hsa051320.77256474
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77253762
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77233538
74TNF signaling pathway_Homo sapiens_hsa046680.77209616
75MAPK signaling pathway_Homo sapiens_hsa040100.76815095
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76327974
77Alcoholism_Homo sapiens_hsa050340.76222366
78Type II diabetes mellitus_Homo sapiens_hsa049300.75994263
79HTLV-I infection_Homo sapiens_hsa051660.75849177
80p53 signaling pathway_Homo sapiens_hsa041150.75180031
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75046035
82Pathways in cancer_Homo sapiens_hsa052000.74690285
83Hepatitis B_Homo sapiens_hsa051610.74622932
84Axon guidance_Homo sapiens_hsa043600.74557260
85Graft-versus-host disease_Homo sapiens_hsa053320.74246113
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73864294
87Measles_Homo sapiens_hsa051620.72508081
88RNA transport_Homo sapiens_hsa030130.72504605
89Influenza A_Homo sapiens_hsa051640.72370822
90HIF-1 signaling pathway_Homo sapiens_hsa040660.71840712
91Glioma_Homo sapiens_hsa052140.71602813
92African trypanosomiasis_Homo sapiens_hsa051430.71578202
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71532358
94Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71024342
95Insulin secretion_Homo sapiens_hsa049110.70559874
96Carbon metabolism_Homo sapiens_hsa012000.70031302
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.69796477
98Rheumatoid arthritis_Homo sapiens_hsa053230.69666211
99Bladder cancer_Homo sapiens_hsa052190.69410917
100Dorso-ventral axis formation_Homo sapiens_hsa043200.68591829
101Ribosome_Homo sapiens_hsa030100.68126722
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67833087
103RNA degradation_Homo sapiens_hsa030180.67647576
104Vitamin B6 metabolism_Homo sapiens_hsa007500.67569837
105Pertussis_Homo sapiens_hsa051330.67021791
106Neurotrophin signaling pathway_Homo sapiens_hsa047220.66958413
107Long-term potentiation_Homo sapiens_hsa047200.66111996
108RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.65668463
109B cell receptor signaling pathway_Homo sapiens_hsa046620.65365618
110Viral myocarditis_Homo sapiens_hsa054160.65031356
111Serotonergic synapse_Homo sapiens_hsa047260.65024060
112Herpes simplex infection_Homo sapiens_hsa051680.64965601
113Platelet activation_Homo sapiens_hsa046110.64911797
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64497922
115Cholinergic synapse_Homo sapiens_hsa047250.63752646
116Inositol phosphate metabolism_Homo sapiens_hsa005620.63501784
117Shigellosis_Homo sapiens_hsa051310.63495740
118Oocyte meiosis_Homo sapiens_hsa041140.63099054
119Phagosome_Homo sapiens_hsa041450.62939945
120ErbB signaling pathway_Homo sapiens_hsa040120.62379965
121Chemokine signaling pathway_Homo sapiens_hsa040620.62130843
122Wnt signaling pathway_Homo sapiens_hsa043100.61796098
123Primary immunodeficiency_Homo sapiens_hsa053400.61706771
124Steroid biosynthesis_Homo sapiens_hsa001000.60715073
125Rap1 signaling pathway_Homo sapiens_hsa040150.60450594
126Olfactory transduction_Homo sapiens_hsa047400.59745298
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59332996
128TGF-beta signaling pathway_Homo sapiens_hsa043500.58141394
129Basal cell carcinoma_Homo sapiens_hsa052170.54453173
130Protein export_Homo sapiens_hsa030600.52967591
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48852017
132Propanoate metabolism_Homo sapiens_hsa006400.47385881
133N-Glycan biosynthesis_Homo sapiens_hsa005100.47158329
134Tight junction_Homo sapiens_hsa045300.47009096
135Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46840000
136Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46524180
137mTOR signaling pathway_Homo sapiens_hsa041500.46271182
138Proteoglycans in cancer_Homo sapiens_hsa052050.45337286
139Hedgehog signaling pathway_Homo sapiens_hsa043400.42637683
140Folate biosynthesis_Homo sapiens_hsa007900.39349285
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38760661
142Fatty acid biosynthesis_Homo sapiens_hsa000610.38584018
143Proteasome_Homo sapiens_hsa030500.37054837
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36980004
145Arginine biosynthesis_Homo sapiens_hsa002200.34738191
146Insulin signaling pathway_Homo sapiens_hsa049100.34418834
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.33547052
148Nicotine addiction_Homo sapiens_hsa050330.28976735
149Gap junction_Homo sapiens_hsa045400.28574375
150Epstein-Barr virus infection_Homo sapiens_hsa051690.27324462
151Pentose phosphate pathway_Homo sapiens_hsa000300.27154912
152Melanogenesis_Homo sapiens_hsa049160.26039131
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25789620
154Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22514458
155Nitrogen metabolism_Homo sapiens_hsa009100.22448305
156Long-term depression_Homo sapiens_hsa047300.22243289

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