CHM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.74463173
2presynaptic membrane assembly (GO:0097105)4.56832396
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52925832
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.46010873
5vocalization behavior (GO:0071625)4.44504533
6regulation of synaptic vesicle exocytosis (GO:2000300)4.40915788
7synaptic vesicle maturation (GO:0016188)4.39366333
8synaptic vesicle exocytosis (GO:0016079)4.37830760
9glutamate secretion (GO:0014047)4.36818294
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.32512701
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.19889796
12neurotransmitter-gated ion channel clustering (GO:0072578)4.13378655
13presynaptic membrane organization (GO:0097090)4.05963989
14locomotory exploration behavior (GO:0035641)4.04503210
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.03354167
16neuronal action potential propagation (GO:0019227)4.01768241
17protein localization to synapse (GO:0035418)3.95362606
18gamma-aminobutyric acid signaling pathway (GO:0007214)3.89212352
19regulation of glutamate receptor signaling pathway (GO:1900449)3.85946792
20negative regulation of synaptic transmission, GABAergic (GO:0032229)3.83626294
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.81424407
22regulation of synaptic vesicle transport (GO:1902803)3.69843162
23positive regulation of protein autophosphorylation (GO:0031954)3.69683997
24neuron-neuron synaptic transmission (GO:0007270)3.68856176
25righting reflex (GO:0060013)3.59083151
26regulation of glucokinase activity (GO:0033131)3.57593286
27regulation of hexokinase activity (GO:1903299)3.57593286
28positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.56483847
29synaptic transmission, glutamatergic (GO:0035249)3.55883139
30long-term synaptic potentiation (GO:0060291)3.53531122
31exploration behavior (GO:0035640)3.53360420
32regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50973887
33glutamate receptor signaling pathway (GO:0007215)3.48765288
34neuron recognition (GO:0008038)3.48473363
35postsynaptic membrane organization (GO:0001941)3.39577454
36cerebellar granule cell differentiation (GO:0021707)3.33813127
37neurotransmitter secretion (GO:0007269)3.32603696
38atrial cardiac muscle cell action potential (GO:0086014)3.29451640
39regulation of neuronal synaptic plasticity (GO:0048168)3.29244596
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.28928121
41startle response (GO:0001964)3.28130060
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.26581691
43inositol phosphate-mediated signaling (GO:0048016)3.22491455
44glycosphingolipid biosynthetic process (GO:0006688)3.18062582
45negative regulation of neurotransmitter transport (GO:0051589)3.14394900
46regulation of synaptic plasticity (GO:0048167)3.12332039
47regulation of sarcomere organization (GO:0060297)3.11997191
48regulation of dendritic spine morphogenesis (GO:0061001)3.11953521
49axonal fasciculation (GO:0007413)3.10224388
50regulation of postsynaptic membrane potential (GO:0060078)3.10066626
51dendritic spine morphogenesis (GO:0060997)3.09252164
52gamma-aminobutyric acid transport (GO:0015812)3.07484321
53UDP-N-acetylglucosamine metabolic process (GO:0006047)3.07129947
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06748779
55negative regulation of neurotransmitter secretion (GO:0046929)3.01367077
56regulation of synaptic transmission, glutamatergic (GO:0051966)2.99304569
57positive regulation of muscle hypertrophy (GO:0014742)2.98917139
58positive regulation of cardiac muscle hypertrophy (GO:0010613)2.98917139
59cellular potassium ion homeostasis (GO:0030007)2.98433940
60negative regulation of cytosolic calcium ion concentration (GO:0051481)2.98004034
61positive regulation of glycolytic process (GO:0045821)2.95689819
62response to histamine (GO:0034776)2.93659602
63cerebellar Purkinje cell differentiation (GO:0021702)2.93153092
64regulation of dendritic spine development (GO:0060998)2.90332831
65transmission of nerve impulse (GO:0019226)2.89313866
66positive regulation of membrane potential (GO:0045838)2.85364993
67vascular smooth muscle contraction (GO:0014829)2.84984731
68vesicle transport along microtubule (GO:0047496)2.84976268
69regulation of glutamate secretion (GO:0014048)2.84754991
70signal peptide processing (GO:0006465)2.83109664
71positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.81308052
72nerve growth factor signaling pathway (GO:0038180)2.79566497
73single strand break repair (GO:0000012)2.79340974
74C4-dicarboxylate transport (GO:0015740)2.78943734
75protein targeting to Golgi (GO:0000042)2.77454791
76long-term memory (GO:0007616)2.76487111
77negative regulation of dendrite morphogenesis (GO:0050774)2.75234601
78dendrite morphogenesis (GO:0048813)2.74632574
79organelle transport along microtubule (GO:0072384)2.74218197
80long term synaptic depression (GO:0060292)2.74185477
81synaptic vesicle endocytosis (GO:0048488)2.73370107
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.72501646
83detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.72203237
84layer formation in cerebral cortex (GO:0021819)2.71983995
85regulation of female receptivity (GO:0045924)2.71074860
86mechanosensory behavior (GO:0007638)2.70519282
87macroautophagy (GO:0016236)2.70344649
88regulation of neurotransmitter secretion (GO:0046928)2.70262969
89inositol phosphate catabolic process (GO:0071545)2.69491268
90positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.69169804
91synapse assembly (GO:0007416)2.69038274
92COPII vesicle coating (GO:0048208)2.68544297
93regulation of respiratory system process (GO:0044065)2.67771939
94negative regulation of dendrite development (GO:2000171)2.67001437
95innervation (GO:0060384)2.66909187
96clathrin coat assembly (GO:0048268)2.66725054
97regulation of vesicle fusion (GO:0031338)2.66492839
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66061503
99negative regulation of neurological system process (GO:0031645)2.65489506
100reflex (GO:0060004)2.65053776
101neurotransmitter transport (GO:0006836)2.64244481
102lactate metabolic process (GO:0006089)2.63443781
103artery development (GO:0060840)2.62806831
104detection of calcium ion (GO:0005513)2.62784255
105negative regulation of DNA-dependent DNA replication (GO:2000104)2.62182656
106membrane assembly (GO:0071709)2.61578656
107serotonin metabolic process (GO:0042428)2.60714651
108protein targeting to vacuole (GO:0006623)2.60596090
109protein targeting to lysosome (GO:0006622)2.60596090
110establishment of protein localization to vacuole (GO:0072666)2.60596090
111regulation of beta-amyloid formation (GO:1902003)2.60439791
112myelin assembly (GO:0032288)2.60291716
113learning (GO:0007612)2.59486082
114proline transport (GO:0015824)2.59014128
115dendrite development (GO:0016358)2.57703153
116behavioral defense response (GO:0002209)2.57609894
117behavioral fear response (GO:0001662)2.57609894
118negative regulation of synaptic transmission (GO:0050805)2.56633229
119regulation of synapse structural plasticity (GO:0051823)2.56163199
120positive regulation of synapse assembly (GO:0051965)2.55358594
121negative regulation of amino acid transport (GO:0051956)2.53873629
122positive regulation of synapse maturation (GO:0090129)2.52841382
123regulation of amyloid precursor protein catabolic process (GO:1902991)2.52692061
124positive regulation of cardiac muscle cell differentiation (GO:2000727)2.51499141
125pancreas development (GO:0031016)2.51411300
126magnesium ion transport (GO:0015693)2.51318656
127G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.50404334
128establishment of protein localization to Golgi (GO:0072600)2.50103804
129regulation of protein glycosylation (GO:0060049)2.49327626
130* protein prenylation (GO:0018342)2.48263047
131* prenylation (GO:0097354)2.48263047
132membrane depolarization (GO:0051899)2.47289139
133establishment of nucleus localization (GO:0040023)2.46706504
134regulation of synaptic transmission, GABAergic (GO:0032228)2.46509830
135regulation of protein autophosphorylation (GO:0031952)2.45343745
136platelet dense granule organization (GO:0060155)2.45261580
137mitotic sister chromatid cohesion (GO:0007064)2.44690404
138cellular response to ethanol (GO:0071361)2.44140198
139polyol catabolic process (GO:0046174)2.43786358
140sphingomyelin metabolic process (GO:0006684)2.41280228
141interleukin-6-mediated signaling pathway (GO:0070102)2.40936638
142positive regulation of dendritic spine morphogenesis (GO:0061003)2.39329006
143lymphangiogenesis (GO:0001946)2.37649023
144regulation of DNA endoreduplication (GO:0032875)2.37298992
145artery smooth muscle contraction (GO:0014824)2.36815530
146regulation of Golgi to plasma membrane protein transport (GO:0042996)2.35208311
147neural tube formation (GO:0001841)2.34915529
148inositol phosphate dephosphorylation (GO:0046855)2.34268524
149phosphorylated carbohydrate dephosphorylation (GO:0046838)2.34268524
150retrograde transport, vesicle recycling within Golgi (GO:0000301)2.32624898
151cullin deneddylation (GO:0010388)2.31744325
152response to pheromone (GO:0019236)2.29306317
153response to lipoprotein particle (GO:0055094)2.28071691
154cyclic nucleotide catabolic process (GO:0009214)2.28041460
155positive regulation of glycoprotein biosynthetic process (GO:0010560)2.27358279
156protein localization to microtubule cytoskeleton (GO:0072698)2.26982646
157cellular ketone body metabolic process (GO:0046950)2.26140909
158insulin secretion (GO:0030073)2.25030493
159protein K11-linked deubiquitination (GO:0035871)2.24372494
160regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.23552508
161indolalkylamine metabolic process (GO:0006586)2.23538336
162retinal cone cell development (GO:0046549)2.22290683
163regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.21406719
164tonic smooth muscle contraction (GO:0014820)2.20231477
165regulation of transmission of nerve impulse (GO:0051969)2.20223820
166positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.19997069
167ketone body metabolic process (GO:1902224)2.19823470
168primary amino compound metabolic process (GO:1901160)2.19473540
169smooth muscle contraction (GO:0006939)2.19217102
170secondary heart field specification (GO:0003139)2.16107087
171heart field specification (GO:0003128)2.16107087
172ER to Golgi vesicle-mediated transport (GO:0006888)2.14145695
173positive regulation of macroautophagy (GO:0016239)2.14067941
174phasic smooth muscle contraction (GO:0014821)2.13041552
175positive regulation of oligodendrocyte differentiation (GO:0048714)2.12889525
176negative regulation of systemic arterial blood pressure (GO:0003085)2.12481029
177photoreceptor cell maintenance (GO:0045494)2.12400347
178respiratory chain complex IV assembly (GO:0008535)2.12121725
179keratinocyte development (GO:0003334)2.10989998
180cAMP catabolic process (GO:0006198)2.10859632
181central nervous system neuron axonogenesis (GO:0021955)2.09664229
182regulation of acyl-CoA biosynthetic process (GO:0050812)2.09189763
183regulation of acrosome reaction (GO:0060046)2.08964842

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.00723853
2EZH2_22144423_ChIP-Seq_EOC_Human3.99507880
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.52311677
4SMAD_19615063_ChIP-ChIP_OVARY_Human2.52032061
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47460202
6TAF15_26573619_Chip-Seq_HEK293_Human2.43453383
7AR_21572438_ChIP-Seq_LNCaP_Human2.39465707
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31922049
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.24821919
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.21477663
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14338209
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14235697
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11213797
14P300_19829295_ChIP-Seq_ESCs_Human2.10670917
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06135419
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02286907
17SMAD4_21799915_ChIP-Seq_A2780_Human2.00295653
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.98939855
19OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96505536
20SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.95030787
21EZH2_18974828_ChIP-Seq_MESCs_Mouse1.94835885
22RNF2_18974828_ChIP-Seq_MESCs_Mouse1.94835885
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.89052701
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.87200098
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.86197463
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84588617
27ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83612414
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81834154
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.79420736
30PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78204203
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76155579
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.75553842
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75326714
34SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73927186
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.73673684
36SMAD3_21741376_ChIP-Seq_EPCs_Human1.72604417
37SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70900396
38REST_21632747_ChIP-Seq_MESCs_Mouse1.68859710
39EZH2_27294783_Chip-Seq_NPCs_Mouse1.68099176
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66185197
41SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.65269048
42FUS_26573619_Chip-Seq_HEK293_Human1.65129149
43DROSHA_22980978_ChIP-Seq_HELA_Human1.63161857
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.61504289
45TP53_18474530_ChIP-ChIP_U2OS_Human1.61283546
46RNF2_27304074_Chip-Seq_ESCs_Mouse1.59584935
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.57597018
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.56544441
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.56544441
50ER_23166858_ChIP-Seq_MCF-7_Human1.53970982
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53672027
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53338654
53* ARNT_22903824_ChIP-Seq_MCF-7_Human1.52934692
54TP53_16413492_ChIP-PET_HCT116_Human1.52613144
55NFE2_27457419_Chip-Seq_LIVER_Mouse1.51830490
56AR_25329375_ChIP-Seq_VCAP_Human1.50410500
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50394332
58* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.49469294
59* SOX2_21211035_ChIP-Seq_LN229_Gbm1.48625236
60AHR_22903824_ChIP-Seq_MCF-7_Human1.47926992
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.47174043
62STAT3_23295773_ChIP-Seq_U87_Human1.46922901
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44574286
64CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.41530376
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.41385221
66ZNF274_21170338_ChIP-Seq_K562_Hela1.40775908
67CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40066322
68PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38851790
69* ELK1_19687146_ChIP-ChIP_HELA_Human1.38202368
70IGF1R_20145208_ChIP-Seq_DFB_Human1.34859659
71RXR_22108803_ChIP-Seq_LS180_Human1.34528042
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33722647
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32759446
74SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31742657
75ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31719890
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.31324272
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30947276
78TCF4_23295773_ChIP-Seq_U87_Human1.29784142
79SUZ12_27294783_Chip-Seq_ESCs_Mouse1.29496840
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.28850156
81CDX2_22108803_ChIP-Seq_LS180_Human1.28356472
82NANOG_18555785_Chip-Seq_ESCs_Mouse1.28319725
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.27941156
84EP300_21415370_ChIP-Seq_HL-1_Mouse1.27840834
85CJUN_26792858_Chip-Seq_BT549_Human1.27473195
86TCF4_22108803_ChIP-Seq_LS180_Human1.27401079
87SMAD4_21741376_ChIP-Seq_EPCs_Human1.25079799
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.24535572
89BCAT_22108803_ChIP-Seq_LS180_Human1.23732518
90BRD4_25478319_ChIP-Seq_HGPS_Human1.23453044
91PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.22983242
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.22248358
93EZH2_27294783_Chip-Seq_ESCs_Mouse1.21988432
94* EWS_26573619_Chip-Seq_HEK293_Human1.19943916
95* RUNX2_22187159_ChIP-Seq_PCA_Human1.19742653
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.18386464
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18258158
98P300_18555785_Chip-Seq_ESCs_Mouse1.18034736
99TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17456993
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17095547
101PRDM14_20953172_ChIP-Seq_ESCs_Human1.17047781
102EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.16860726
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.15673458
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14048600
105E2F1_18555785_Chip-Seq_ESCs_Mouse1.13812325
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13383531
107REST_18959480_ChIP-ChIP_MESCs_Mouse1.13242963
108SALL1_21062744_ChIP-ChIP_HESCs_Human1.11582149
109JUN_21703547_ChIP-Seq_K562_Human1.10726551
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10636320
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10171909
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.10000496
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09906323
114HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.09362650
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09192802
116NMYC_18555785_Chip-Seq_ESCs_Mouse1.08628658
117* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07656560
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.07519844
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.07070742
120SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06970018
121AR_19668381_ChIP-Seq_PC3_Human1.05172396
122VDR_22108803_ChIP-Seq_LS180_Human1.04962431
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03528359
124EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03522985
125NANOG_19829295_ChIP-Seq_ESCs_Human1.03314196
126SOX2_19829295_ChIP-Seq_ESCs_Human1.03314196
127CBX2_27304074_Chip-Seq_ESCs_Mouse1.03169705
128CBP_20019798_ChIP-Seq_JUKART_Human1.03073995
129IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03073995
130P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02356031
131FOXM1_26456572_ChIP-Seq_MCF-7_Human1.01823388
132KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00819469
133TBX3_20139965_ChIP-Seq_MESCs_Mouse1.00272145
134P53_22387025_ChIP-Seq_ESCs_Mouse0.99659369
135BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96813983
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95404824
137SMAD3_21741376_ChIP-Seq_ESCs_Human0.94479152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern6.17828976
2MP0004859_abnormal_synaptic_plasticity5.57993036
3MP0003195_calcinosis3.99794407
4MP0003635_abnormal_synaptic_transmissio3.77434233
5MP0004270_analgesia3.68597197
6MP0008057_abnormal_DNA_replication3.32658518
7MP0009780_abnormal_chondrocyte_physiolo3.25700165
8MP0009745_abnormal_behavioral_response3.24772887
9MP0002063_abnormal_learning/memory/cond3.17784221
10MP0002064_seizures3.04122703
11MP0009046_muscle_twitch2.92638387
12MP0006054_spinal_hemorrhage2.85934818
13MP0002572_abnormal_emotion/affect_behav2.66903221
14MP0010234_abnormal_vibrissa_follicle2.65937232
15MP0001968_abnormal_touch/_nociception2.49804463
16MP0002734_abnormal_mechanical_nocicepti2.44051536
17MP0002272_abnormal_nervous_system2.34349377
18MP0001486_abnormal_startle_reflex2.33381886
19MP0003329_amyloid_beta_deposits2.22007494
20MP0003950_abnormal_plasma_membrane2.22002882
21MP0000569_abnormal_digit_pigmentation2.21179275
22MP0005423_abnormal_somatic_nervous2.20826701
23MP0003890_abnormal_embryonic-extraembry2.06399042
24MP0002736_abnormal_nociception_after2.01242988
25MP0002735_abnormal_chemical_nociception1.99686718
26MP0001501_abnormal_sleep_pattern1.99446273
27MP0008877_abnormal_DNA_methylation1.98938302
28MP0001440_abnormal_grooming_behavior1.94588653
29MP0010352_gastrointestinal_tract_polyps1.92979895
30MP0000778_abnormal_nervous_system1.91239371
31MP0002067_abnormal_sensory_capabilities1.88860233
32MP0003941_abnormal_skin_development1.87675552
33MP0000372_irregular_coat_pigmentation1.86920383
34MP0010678_abnormal_skin_adnexa1.77449654
35MP0003183_abnormal_peptide_metabolism1.72791166
36MP0004885_abnormal_endolymph1.70312015
37MP0006072_abnormal_retinal_apoptosis1.69492749
38MP0001188_hyperpigmentation1.68512469
39MP0004272_abnormal_basement_membrane1.64446266
40MP0005171_absent_coat_pigmentation1.61756916
41MP0005386_behavior/neurological_phenoty1.61380450
42MP0004924_abnormal_behavior1.61380450
43MP0002733_abnormal_thermal_nociception1.60814391
44MP0008569_lethality_at_weaning1.60687144
45MP0002822_catalepsy1.59708131
46MP0000604_amyloidosis1.59181611
47MP0005174_abnormal_tail_pigmentation1.55108321
48MP0002938_white_spotting1.54128573
49MP0003633_abnormal_nervous_system1.51842562
50MP0001970_abnormal_pain_threshold1.49888749
51MP0002102_abnormal_ear_morphology1.47603048
52MP0004811_abnormal_neuron_physiology1.47239103
53MP0004084_abnormal_cardiac_muscle1.46833939
54MP0006276_abnormal_autonomic_nervous1.46043953
55MP0002557_abnormal_social/conspecific_i1.44098633
56MP0010368_abnormal_lymphatic_system1.43688420
57MP0005253_abnormal_eye_physiology1.40625053
58MP0005646_abnormal_pituitary_gland1.39862056
59MP0003631_nervous_system_phenotype1.39209728
60MP0002184_abnormal_innervation1.38877097
61MP0004858_abnormal_nervous_system1.38132237
62MP0005367_renal/urinary_system_phenotyp1.37867808
63MP0000516_abnormal_urinary_system1.37867808
64MP0001177_atelectasis1.37813212
65MP0000920_abnormal_myelination1.37517224
66MP0009697_abnormal_copulation1.36537175
67MP0003787_abnormal_imprinting1.36085778
68MP0002909_abnormal_adrenal_gland1.35809808
69* MP0005551_abnormal_eye_electrophysiolog1.33570765
70MP0000013_abnormal_adipose_tissue1.29141604
71MP0001299_abnormal_eye_distance/1.28778751
72MP0003632_abnormal_nervous_system1.27269050
73MP0003283_abnormal_digestive_organ1.26614440
74MP0003868_abnormal_feces_composition1.25239111
75MP0003690_abnormal_glial_cell1.23685385
76MP0005187_abnormal_penis_morphology1.23176820
77MP0002066_abnormal_motor_capabilities/c1.22827897
78MP0000955_abnormal_spinal_cord1.19389359
79MP0000427_abnormal_hair_cycle1.18301777
80MP0002168_other_aberrant_phenotype1.17088599
81MP0004742_abnormal_vestibular_system1.16367975
82MP0005220_abnormal_exocrine_pancreas1.16253121
83MP0002877_abnormal_melanocyte_morpholog1.15773421
84* MP0002882_abnormal_neuron_morphology1.14611502
85MP0005623_abnormal_meninges_morphology1.12356049
86MP0004142_abnormal_muscle_tone1.10521554
87MP0003634_abnormal_glial_cell1.10501339
88MP0001879_abnormal_lymphatic_vessel1.10494757
89MP0004036_abnormal_muscle_relaxation1.09507349
90MP0005379_endocrine/exocrine_gland_phen1.06747313
91MP0000383_abnormal_hair_follicle1.06450044
92MP0003121_genomic_imprinting1.04976073
93MP0008775_abnormal_heart_ventricle1.03412007
94MP0001944_abnormal_pancreas_morphology1.03239214
95MP0003172_abnormal_lysosome_physiology1.02380727
96MP0002876_abnormal_thyroid_physiology1.01929290
97MP0000371_diluted_coat_color0.99722907
98MP0000647_abnormal_sebaceous_gland0.99695997
99MP0001905_abnormal_dopamine_level0.99694920
100MP0004484_altered_response_of0.97086569
101MP0002837_dystrophic_cardiac_calcinosis0.96028872
102MP0003122_maternal_imprinting0.94188508
103MP0002095_abnormal_skin_pigmentation0.94139876
104MP0003879_abnormal_hair_cell0.94107611
105MP0005084_abnormal_gallbladder_morpholo0.92941205
106MP0001984_abnormal_olfaction0.92580935
107MP0005167_abnormal_blood-brain_barrier0.87204779
108MP0003252_abnormal_bile_duct0.85072631
109MP0002152_abnormal_brain_morphology0.84365752
110MP0002928_abnormal_bile_duct0.83814269
111MP0003943_abnormal_hepatobiliary_system0.82940144
112MP0003937_abnormal_limbs/digits/tail_de0.81859019
113MP0003075_altered_response_to0.81669884
114MP0001502_abnormal_circadian_rhythm0.80531103
115MP0001529_abnormal_vocalization0.79744384
116MP0001756_abnormal_urination0.77932832
117MP0004043_abnormal_pH_regulation0.74623873
118* MP0002229_neurodegeneration0.74457383
119MP0003045_fibrosis0.73781999
120MP0001943_abnormal_respiration0.73741245
121MP0003300_gastrointestinal_ulcer0.72076090
122MP0001963_abnormal_hearing_physiology0.71512439
123MP0004510_myositis0.71258493
124MP0002160_abnormal_reproductive_system0.70793857
125MP0008007_abnormal_cellular_replicative0.70432942
126MP0004883_abnormal_blood_vessel0.68938229
127MP0005645_abnormal_hypothalamus_physiol0.67279265
128MP0002069_abnormal_eating/drinking_beha0.66910472
129MP0005620_abnormal_muscle_contractility0.66826382
130MP0005395_other_phenotype0.66591189
131MP0004085_abnormal_heartbeat0.65094284
132MP0002009_preneoplasia0.65003094
133MP0002133_abnormal_respiratory_system0.64753598
134MP0005388_respiratory_system_phenotype0.64753598
135MP0010386_abnormal_urinary_bladder0.63100271
136MP0008874_decreased_physiological_sensi0.62700773
137MP0002163_abnormal_gland_morphology0.62261105
138MP0005535_abnormal_body_temperature0.61260669
139MP0004145_abnormal_muscle_electrophysio0.59357824
140MP0000015_abnormal_ear_pigmentation0.59181476
141MP0004134_abnormal_chest_morphology0.59141868
142MP0001485_abnormal_pinna_reflex0.57934436
143MP0001958_emphysema0.56074981
144MP0005166_decreased_susceptibility_to0.54874675
145MP0002090_abnormal_vision0.54734385
146MP0000631_abnormal_neuroendocrine_gland0.52685507
147MP0003091_abnormal_cell_migration0.52116093
148MP0004215_abnormal_myocardial_fiber0.51830214
149MP0002295_abnormal_pulmonary_circulatio0.51264153
150MP0002254_reproductive_system_inflammat0.46017240
151MP0005595_abnormal_vascular_smooth0.44444897

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.61415475
2Atonic seizures (HP:0010819)5.02147330
3Epileptic encephalopathy (HP:0200134)4.75364994
4Focal seizures (HP:0007359)4.74282560
5Hyperventilation (HP:0002883)4.62231516
6Febrile seizures (HP:0002373)3.96552130
7Absence seizures (HP:0002121)3.94688056
8Volvulus (HP:0002580)3.91990521
9Broad-based gait (HP:0002136)3.85759680
10Excessive salivation (HP:0003781)3.82343583
11Drooling (HP:0002307)3.82343583
12Visual hallucinations (HP:0002367)3.66477138
13Dialeptic seizures (HP:0011146)3.66407089
14Diplopia (HP:0000651)3.61608157
15Abnormality of binocular vision (HP:0011514)3.61608157
16Neurofibrillary tangles (HP:0002185)3.61583349
17Generalized tonic-clonic seizures (HP:0002069)3.53668032
18Supranuclear gaze palsy (HP:0000605)3.51919275
19Cerebral inclusion bodies (HP:0100314)3.46351710
20Gaze-evoked nystagmus (HP:0000640)3.44584827
21Progressive cerebellar ataxia (HP:0002073)3.44350245
22Dysdiadochokinesis (HP:0002075)3.36047058
23Insidious onset (HP:0003587)3.21051221
24Termporal pattern (HP:0011008)3.21051221
25Truncal ataxia (HP:0002078)3.17307980
26Intestinal atresia (HP:0011100)3.08288266
27Scanning speech (HP:0002168)3.02733940
28Papillary thyroid carcinoma (HP:0002895)3.00861989
29Impaired smooth pursuit (HP:0007772)2.97473710
30Absent speech (HP:0001344)2.95895624
31Hypothermia (HP:0002045)2.93188249
32Myokymia (HP:0002411)2.90886013
33Dysmetria (HP:0001310)2.87403787
34Genetic anticipation (HP:0003743)2.86552667
35Abnormality of salivation (HP:0100755)2.84451541
36Renal cortical cysts (HP:0000803)2.80338795
37Protruding tongue (HP:0010808)2.76091776
38Action tremor (HP:0002345)2.75522489
39Progressive inability to walk (HP:0002505)2.68214988
40Resting tremor (HP:0002322)2.67337284
41Clumsiness (HP:0002312)2.64459246
42Postural instability (HP:0002172)2.63712499
43Hypoglycemic seizures (HP:0002173)2.61589187
44Large for gestational age (HP:0001520)2.60832715
45Blue irides (HP:0000635)2.59943797
46Hypoglycemic coma (HP:0001325)2.59753324
47Aqueductal stenosis (HP:0002410)2.56623180
48Fair hair (HP:0002286)2.55814744
49Impaired vibration sensation in the lower limbs (HP:0002166)2.48822119
50Epileptiform EEG discharges (HP:0011182)2.46594594
51Neoplasm of the adrenal cortex (HP:0100641)2.44390937
52Abnormality of the renal cortex (HP:0011035)2.43000217
53Urinary bladder sphincter dysfunction (HP:0002839)2.41392646
54Generalized hypopigmentation of hair (HP:0011358)2.39872440
55Thyroiditis (HP:0100646)2.39656132
56Hyperglycemia (HP:0003074)2.39537911
57Thyroid carcinoma (HP:0002890)2.39062502
58Widely spaced teeth (HP:0000687)2.38272037
59Papilledema (HP:0001085)2.37159959
60Intention tremor (HP:0002080)2.37018095
61Medial flaring of the eyebrow (HP:0010747)2.36511909
62Urinary urgency (HP:0000012)2.36260242
63Thickened helices (HP:0000391)2.35231913
64Abnormality of ocular smooth pursuit (HP:0000617)2.33689717
65Depression (HP:0000716)2.30793336
66Stereotypic behavior (HP:0000733)2.29920951
67Inappropriate behavior (HP:0000719)2.29834641
68Poor eye contact (HP:0000817)2.29527788
69Abnormality of the corticospinal tract (HP:0002492)2.28780612
70Bradykinesia (HP:0002067)2.27996120
71Hyperinsulinemic hypoglycemia (HP:0000825)2.27831475
72Glioma (HP:0009733)2.26371042
73Akinesia (HP:0002304)2.24682485
74Hypoplastic labia majora (HP:0000059)2.22441080
75Anxiety (HP:0000739)2.20349598
76Congenital sensorineural hearing impairment (HP:0008527)2.20280478
77Neuronal loss in central nervous system (HP:0002529)2.20194673
78Aplasia involving bones of the extremities (HP:0009825)2.20006613
79Aplasia involving bones of the upper limbs (HP:0009823)2.20006613
80Aplasia of the phalanges of the hand (HP:0009802)2.20006613
81EEG with generalized epileptiform discharges (HP:0011198)2.19991307
82Epidermoid cyst (HP:0200040)2.18826794
83Abnormal social behavior (HP:0012433)2.17435867
84Impaired social interactions (HP:0000735)2.17435867
85Short chin (HP:0000331)2.16999631
86Amblyopia (HP:0000646)2.15304797
87Metaphyseal dysplasia (HP:0100255)2.14859340
88Dysmetric saccades (HP:0000641)2.11989833
89Abnormal hair whorl (HP:0010721)2.11317707
90Hemiparesis (HP:0001269)2.10438036
91Megalencephaly (HP:0001355)2.10421189
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.09441175
93Degeneration of the lateral corticospinal tracts (HP:0002314)2.09441175
94Delayed gross motor development (HP:0002194)2.09144825
95Pancreatic fibrosis (HP:0100732)2.08445431
96Gait ataxia (HP:0002066)2.07560349
97Abnormal eating behavior (HP:0100738)2.06906585
98Astrocytoma (HP:0009592)2.06113913
99Abnormality of the astrocytes (HP:0100707)2.06113913
100Albinism (HP:0001022)2.05168767
101Hematochezia (HP:0002573)2.04721409
102Pancreatic cysts (HP:0001737)2.03236760
103Mutism (HP:0002300)2.01894847
104Inability to walk (HP:0002540)2.01680939
105Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.99311981
106Abnormality of the labia majora (HP:0012881)1.98984977
107Hypsarrhythmia (HP:0002521)1.98769957
108Abnormality of methionine metabolism (HP:0010901)1.97965598
109Cardiovascular calcification (HP:0011915)1.93453560
110Lower limb asymmetry (HP:0100559)1.92772416
111Pheochromocytoma (HP:0002666)1.92563660
112Vascular calcification (HP:0004934)1.90045577
113Lower limb amyotrophy (HP:0007210)1.87797374
114Agitation (HP:0000713)1.85255523
115Abnormality of incisor morphology (HP:0011063)1.84890514
116Exotropia (HP:0000577)1.84341929
117Rhabdomyosarcoma (HP:0002859)1.82481266
118Lower limb muscle weakness (HP:0007340)1.81812463
119True hermaphroditism (HP:0010459)1.81496443
120Ketoacidosis (HP:0001993)1.81348103
121Open mouth (HP:0000194)1.80366670
122Adrenal hypoplasia (HP:0000835)1.79710016
123Molar tooth sign on MRI (HP:0002419)1.79463215
124Abnormality of midbrain morphology (HP:0002418)1.79463215
125Abnormality of aspartate family amino acid metabolism (HP:0010899)1.78081598
126Generalized myoclonic seizures (HP:0002123)1.77542919
127Heterochromia iridis (HP:0001100)1.77321684
128Neuroendocrine neoplasm (HP:0100634)1.77227013
129Prominent supraorbital ridges (HP:0000336)1.75129852
130Apathy (HP:0000741)1.74802256
131Hyperlipoproteinemia (HP:0010980)1.74695388
132Relative macrocephaly (HP:0004482)1.74243846
133Rigidity (HP:0002063)1.74160891
134Furrowed tongue (HP:0000221)1.73637032
135Submucous cleft hard palate (HP:0000176)1.73457722
136Ankle clonus (HP:0011448)1.73438930
137Abnormality of endocrine pancreas physiology (HP:0012093)1.73258096
138Abnormality of the pancreatic islet cells (HP:0006476)1.73258096
139Neoplasm of the peripheral nervous system (HP:0100007)1.73224967
140Abnormality of the ischium (HP:0003174)1.72296448
141Spastic gait (HP:0002064)1.72144998
142Hypokinesia (HP:0002375)1.72091855
143Gait imbalance (HP:0002141)1.70973840
144Hypoalphalipoproteinemia (HP:0003233)1.70452823
145Symptomatic seizures (HP:0011145)1.70055867
146Hypolipoproteinemia (HP:0010981)1.69144102
147Congenital primary aphakia (HP:0007707)1.69044078
148Hemiplegia (HP:0002301)1.68350999
149Pulmonic stenosis (HP:0001642)1.67487363
150Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.66854272
151Narrow nasal bridge (HP:0000446)1.66533836
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.66425907
153Impaired vibratory sensation (HP:0002495)1.66390382
154Cupped ear (HP:0000378)1.66018758
155Genital tract atresia (HP:0001827)1.65897072
156Diminished movement (HP:0002374)1.65555563
157Hypoplastic ischia (HP:0003175)1.65060103
158Hamartoma of the eye (HP:0010568)1.64278446
159Abnormality of the intrinsic pathway (HP:0010989)1.62947310
160Labial hypoplasia (HP:0000066)1.62659714
161Abnormal biliary tract morphology (HP:0012440)1.62033407
162Hypoproteinemia (HP:0003075)1.61066434
163Cutaneous melanoma (HP:0012056)1.60604632
164Abnormality of the renal medulla (HP:0100957)1.60081375
165Downturned corners of mouth (HP:0002714)1.59506700
166Paraplegia (HP:0010550)1.58617860
167Nephronophthisis (HP:0000090)1.57901851
168Muscular hypotonia of the trunk (HP:0008936)1.57894129
169Vaginal atresia (HP:0000148)1.56716931
170Ependymoma (HP:0002888)1.56240951
171Postural tremor (HP:0002174)1.55423417
172Mitral stenosis (HP:0001718)1.55409556

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.33785470
2EPHA43.95014928
3NTRK33.66565729
4WNK33.31190356
5EIF2AK33.07616991
6MAP3K122.96583094
7RIPK42.75067287
8LATS12.38981010
9STK38L2.32546768
10DAPK22.27373551
11NUAK12.26398127
12MAP2K72.21846120
13BMPR1B2.16861628
14ACVR1B2.14753479
15PLK22.13755271
16MAP3K42.13067605
17MINK12.09601993
18MARK11.97989111
19MAP3K91.92644935
20BCR1.84025460
21MAP2K41.77003624
22MAP3K21.62580380
23GRK71.59900538
24AKT31.58561207
25OXSR11.58056069
26CAMKK11.51836657
27MAP4K21.51833356
28PNCK1.50376614
29STK391.48247573
30NTRK11.45724119
31CDK191.42226844
32STK31.42183092
33CAMKK21.38477413
34SGK21.38362920
35BMPR21.36362844
36FGFR21.33491598
37KSR11.33202717
38ZAK1.32484174
39DAPK11.32332451
40PLK31.28263008
41CDK51.28244778
42SGK2231.27988101
43SGK4941.27988101
44SIK31.26352402
45PRKD31.25790542
46MAPK131.22976632
47GRK51.20269599
48ERBB31.19455639
49FES1.19438209
50WNK11.14912429
51MET1.14363774
52MAP3K131.13487737
53PRPF4B1.12678566
54FER1.09009446
55GRK11.08965857
56FRK1.07043168
57INSRR1.06103514
58CAMK2B1.04523091
59PRKCE1.04076608
60PAK61.02540968
61CAMK2A1.01693450
62FGFR31.00801938
63SGK31.00265398
64MKNK20.99202038
65TAF10.99114220
66TSSK60.97251825
67EIF2AK10.95244681
68PRKCG0.94855263
69PTK2B0.93550735
70FGR0.92021113
71TNIK0.91637387
72SGK10.90656995
73CSNK1G10.88721739
74BRSK20.88126761
75NTRK20.82742852
76MUSK0.82345327
77TIE10.82241200
78PRKCH0.80018466
79SIK20.79766095
80UHMK10.79572748
81NEK60.79461083
82NEK90.79260995
83PAK30.79135951
84EPHA30.78819983
85TRIM280.77670932
86TGFBR10.77467874
87PINK10.76293658
88SCYL20.75777102
89ADRBK20.73618858
90CDK140.70879108
91PDGFRA0.69513331
92CDK180.69499633
93CSNK1G20.69151707
94LIMK10.69050424
95YES10.68899355
96RET0.68866648
97EIF2AK20.66670456
98PIK3CG0.65764339
99KSR20.65353765
100WEE10.65297655
101CAMK1G0.63475023
102CSNK1G30.63338571
103PKN10.62380223
104OBSCN0.61390974
105CDK150.60269921
106NEK10.59982080
107CAMK2D0.59400831
108MELK0.58942396
109TAOK30.56956793
110MST40.56880329
111STK380.55888698
112MAP3K140.54851496
113PRKCQ0.54374017
114FYN0.53292515
115ROCK20.51534456
116CSNK1A1L0.51531317
117MAP3K70.51292825
118MKNK10.50849142
119JAK10.48994939
120RAF10.48669486
121PRKG10.48481569
122PDGFRB0.48451511
123RPS6KA30.47950546
124MST1R0.47778486
125MAPK100.47692395
126TEC0.44349043
127PLK40.43140717
128CDK11A0.43073766
129TXK0.43069493
130PBK0.41260022
131STK240.41162944
132ATM0.39827782
133LATS20.39530232
134PRKCB0.38795778
135MYLK0.38739728
136TYRO30.38461597
137PIK3CA0.37979546
138PDK10.37777506
139MAP2K10.37648666
140ADRBK10.36993415
141MAP3K50.36987157
142CAMK2G0.36845971
143ALK0.36629002
144STK110.36589314
145CDK30.36116080
146TRPM70.35635460
147TGFBR20.34557340
148ROCK10.34400813
149PDPK10.33631401
150ERBB40.33628330
151CAMK40.33544619
152PHKG10.32762388
153PHKG20.32762388
154WNK40.31675405
155CAMK10.31624606
156HIPK20.31573567

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.31097829
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.18064024
3Long-term potentiation_Homo sapiens_hsa047202.62478076
4Synaptic vesicle cycle_Homo sapiens_hsa047212.60676716
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.38515930
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.36521105
7Sulfur metabolism_Homo sapiens_hsa009202.35586636
8GABAergic synapse_Homo sapiens_hsa047272.34869400
9Selenocompound metabolism_Homo sapiens_hsa004502.34799372
10Protein export_Homo sapiens_hsa030602.33354499
11Circadian entrainment_Homo sapiens_hsa047132.20822943
12Morphine addiction_Homo sapiens_hsa050322.20546013
13Amphetamine addiction_Homo sapiens_hsa050312.16369513
14Glutamatergic synapse_Homo sapiens_hsa047242.11648779
15Vitamin B6 metabolism_Homo sapiens_hsa007501.99422636
16Butanoate metabolism_Homo sapiens_hsa006501.99154083
17Olfactory transduction_Homo sapiens_hsa047401.94111748
18Dopaminergic synapse_Homo sapiens_hsa047281.88233311
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86863289
20Long-term depression_Homo sapiens_hsa047301.84356989
21Non-homologous end-joining_Homo sapiens_hsa034501.81079509
22Collecting duct acid secretion_Homo sapiens_hsa049661.73225805
23Steroid biosynthesis_Homo sapiens_hsa001001.73187877
24Salivary secretion_Homo sapiens_hsa049701.72352018
25Insulin secretion_Homo sapiens_hsa049111.71986723
26Fatty acid elongation_Homo sapiens_hsa000621.69775249
27Propanoate metabolism_Homo sapiens_hsa006401.67698971
28Renin secretion_Homo sapiens_hsa049241.66983662
29Gastric acid secretion_Homo sapiens_hsa049711.61403456
30Serotonergic synapse_Homo sapiens_hsa047261.60425091
31Basal transcription factors_Homo sapiens_hsa030221.58686227
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58209298
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.54786047
34Taste transduction_Homo sapiens_hsa047421.51838249
35Tryptophan metabolism_Homo sapiens_hsa003801.51221647
36Type I diabetes mellitus_Homo sapiens_hsa049401.48577802
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47780499
38Cholinergic synapse_Homo sapiens_hsa047251.47770586
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47138559
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.42216746
41Sphingolipid metabolism_Homo sapiens_hsa006001.40659471
42Oxytocin signaling pathway_Homo sapiens_hsa049211.39196604
43Vibrio cholerae infection_Homo sapiens_hsa051101.37029400
44Ether lipid metabolism_Homo sapiens_hsa005651.33278270
45Cocaine addiction_Homo sapiens_hsa050301.32998099
46Calcium signaling pathway_Homo sapiens_hsa040201.30073180
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.28816855
48Axon guidance_Homo sapiens_hsa043601.28200808
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23768186
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22276524
51Fatty acid metabolism_Homo sapiens_hsa012121.18204868
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17999088
53Dorso-ventral axis formation_Homo sapiens_hsa043201.16420558
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16396168
55cAMP signaling pathway_Homo sapiens_hsa040241.15114616
56Fatty acid biosynthesis_Homo sapiens_hsa000611.14410688
57Gap junction_Homo sapiens_hsa045401.11370366
58Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09112096
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08935004
60Glioma_Homo sapiens_hsa052141.07662685
61Type II diabetes mellitus_Homo sapiens_hsa049301.07159458
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06481824
63ErbB signaling pathway_Homo sapiens_hsa040121.04886955
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02784323
65GnRH signaling pathway_Homo sapiens_hsa049121.01589105
66Rheumatoid arthritis_Homo sapiens_hsa053231.00821849
67Linoleic acid metabolism_Homo sapiens_hsa005910.99778901
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99185850
69ABC transporters_Homo sapiens_hsa020100.98078659
70Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93335705
71TGF-beta signaling pathway_Homo sapiens_hsa043500.93014720
72Estrogen signaling pathway_Homo sapiens_hsa049150.91961412
73Phagosome_Homo sapiens_hsa041450.91057126
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90329241
75Melanogenesis_Homo sapiens_hsa049160.89378942
76cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88342951
77African trypanosomiasis_Homo sapiens_hsa051430.87778318
78alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.82099977
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.81183294
80Fatty acid degradation_Homo sapiens_hsa000710.80519605
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80421043
82Nitrogen metabolism_Homo sapiens_hsa009100.80057202
83Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.79114178
84Caffeine metabolism_Homo sapiens_hsa002320.78792511
85N-Glycan biosynthesis_Homo sapiens_hsa005100.78465612
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77956787
87Ovarian steroidogenesis_Homo sapiens_hsa049130.76353754
88Renal cell carcinoma_Homo sapiens_hsa052110.75985181
89Thyroid hormone synthesis_Homo sapiens_hsa049180.75961963
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75901476
91Peroxisome_Homo sapiens_hsa041460.75460011
92Regulation of autophagy_Homo sapiens_hsa041400.74806415
93MAPK signaling pathway_Homo sapiens_hsa040100.74315305
94Dilated cardiomyopathy_Homo sapiens_hsa054140.72568282
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.72339363
96beta-Alanine metabolism_Homo sapiens_hsa004100.70806849
97Fanconi anemia pathway_Homo sapiens_hsa034600.69447299
98Mineral absorption_Homo sapiens_hsa049780.67875386
99Rap1 signaling pathway_Homo sapiens_hsa040150.66387387
100Ras signaling pathway_Homo sapiens_hsa040140.65205133
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64083307
102RNA degradation_Homo sapiens_hsa030180.63650108
103Phototransduction_Homo sapiens_hsa047440.62776392
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62019607
105Phospholipase D signaling pathway_Homo sapiens_hsa040720.61281658
106Homologous recombination_Homo sapiens_hsa034400.60253345
107Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59431964
108Choline metabolism in cancer_Homo sapiens_hsa052310.59289311
109Pancreatic secretion_Homo sapiens_hsa049720.58396992
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.57756062
111Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57371362
112Inositol phosphate metabolism_Homo sapiens_hsa005620.56685645
113Lysine degradation_Homo sapiens_hsa003100.55952798
114Chemokine signaling pathway_Homo sapiens_hsa040620.55356047
115Allograft rejection_Homo sapiens_hsa053300.54200671
116Tuberculosis_Homo sapiens_hsa051520.52275052
117Wnt signaling pathway_Homo sapiens_hsa043100.52183941
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52079860
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.50752644
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50649988
121One carbon pool by folate_Homo sapiens_hsa006700.50606488
122Oocyte meiosis_Homo sapiens_hsa041140.50272991
123Steroid hormone biosynthesis_Homo sapiens_hsa001400.50240568
124Prion diseases_Homo sapiens_hsa050200.49937544
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49703650
126SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48155710
127Endocytosis_Homo sapiens_hsa041440.47651331
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47645439
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47569164
130Hippo signaling pathway_Homo sapiens_hsa043900.47191042
131Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46053937
132ECM-receptor interaction_Homo sapiens_hsa045120.44952665
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44868793
134Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44622315
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43409868
136Circadian rhythm_Homo sapiens_hsa047100.42903593
137T cell receptor signaling pathway_Homo sapiens_hsa046600.42704733
138Alcoholism_Homo sapiens_hsa050340.42188118
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41963759
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41351043
141Melanoma_Homo sapiens_hsa052180.39815628
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39587300
143Folate biosynthesis_Homo sapiens_hsa007900.39377248
144Glucagon signaling pathway_Homo sapiens_hsa049220.39003984
145Purine metabolism_Homo sapiens_hsa002300.38687680
146Pertussis_Homo sapiens_hsa051330.37188424
147Platelet activation_Homo sapiens_hsa046110.36834774
148Oxidative phosphorylation_Homo sapiens_hsa001900.36711437
149Focal adhesion_Homo sapiens_hsa045100.36596788
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36201048
151Tight junction_Homo sapiens_hsa045300.35932195
152Proteoglycans in cancer_Homo sapiens_hsa052050.35009228
153Salmonella infection_Homo sapiens_hsa051320.34366695
154mTOR signaling pathway_Homo sapiens_hsa041500.33106065
155Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32209152

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