CHIC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)8.37613343
2Golgi transport vesicle coating (GO:0048200)8.37613343
3endocrine pancreas development (GO:0031018)6.87576812
4synaptic vesicle docking involved in exocytosis (GO:0016081)6.64687946
5protein maturation by protein folding (GO:0022417)6.20159020
6glutamate secretion (GO:0014047)6.04856322
7peptide hormone processing (GO:0016486)5.81372949
8synaptic vesicle maturation (GO:0016188)5.75435897
9detection of calcium ion (GO:0005513)5.39819010
10cellular potassium ion homeostasis (GO:0030007)5.39183333
11type B pancreatic cell development (GO:0003323)5.34821509
12insulin secretion (GO:0030073)5.32712056
13sodium ion export (GO:0071436)5.25402689
14COPII vesicle coating (GO:0048208)5.20709298
15retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.20281237
16glandular epithelial cell differentiation (GO:0002067)5.18837929
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.16497105
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.11517911
19glandular epithelial cell development (GO:0002068)5.09726484
20regulation of short-term neuronal synaptic plasticity (GO:0048172)5.01460279
21regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.98373953
22regulation of type B pancreatic cell apoptotic process (GO:2000674)4.97185304
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.73329034
24signal peptide processing (GO:0006465)4.67694194
25ER overload response (GO:0006983)4.65996849
26synaptic vesicle exocytosis (GO:0016079)4.62817427
27sequestering of metal ion (GO:0051238)4.52522578
28L-amino acid import (GO:0043092)4.50000423
29positive regulation of insulin secretion (GO:0032024)4.45807246
30regulation of insulin secretion (GO:0050796)4.45657152
31cell communication by electrical coupling (GO:0010644)4.32917993
32cerebellar granule cell differentiation (GO:0021707)4.25451272
33protein retention in ER lumen (GO:0006621)4.23106008
34neuronal action potential propagation (GO:0019227)4.16262070
35regulation of ARF protein signal transduction (GO:0032012)4.11518402
36gamma-aminobutyric acid signaling pathway (GO:0007214)4.08966150
37locomotory exploration behavior (GO:0035641)4.07476713
38activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.07310696
39regulation of peptide hormone secretion (GO:0090276)4.06896022
40regulation of synaptic vesicle transport (GO:1902803)4.06478943
41neurotransmitter secretion (GO:0007269)4.05996739
42regulation of peptide secretion (GO:0002791)4.00839056
43positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.99192024
44columnar/cuboidal epithelial cell development (GO:0002066)3.98505711
45exocrine pancreas development (GO:0031017)3.96583941
46vesicle coating (GO:0006901)3.94264894
47ionotropic glutamate receptor signaling pathway (GO:0035235)3.94100767
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.90539740
49regulation of neuronal synaptic plasticity (GO:0048168)3.88113990
50peptide hormone secretion (GO:0030072)3.87057406
51positive regulation of nuclease activity (GO:0032075)3.81616604
52relaxation of smooth muscle (GO:0044557)3.80715552
53negative regulation of norepinephrine secretion (GO:0010700)3.78965307
54peptide secretion (GO:0002790)3.77780586
55nitric oxide mediated signal transduction (GO:0007263)3.73762557
56intra-Golgi vesicle-mediated transport (GO:0006891)3.71963028
57negative regulation of dendrite morphogenesis (GO:0050774)3.71778981
58regulation of long-term neuronal synaptic plasticity (GO:0048169)3.70114663
59inner ear receptor cell development (GO:0060119)3.68132794
60amino acid import (GO:0043090)3.67841831
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.66090494
62positive regulation of peptide hormone secretion (GO:0090277)3.63862433
63cellular sodium ion homeostasis (GO:0006883)3.58308810
64protein localization to Golgi apparatus (GO:0034067)3.57611314
65regulation of hormone secretion (GO:0046883)3.57231867
66regulation of Rac protein signal transduction (GO:0035020)3.56435006
67positive regulation of peptide secretion (GO:0002793)3.56094983
68vocalization behavior (GO:0071625)3.55131740
69negative regulation of insulin secretion (GO:0046676)3.52819848
70exploration behavior (GO:0035640)3.48912286
71negative regulation of catecholamine secretion (GO:0033604)3.48755838
72potassium ion import (GO:0010107)3.47339350
73regulation of nuclease activity (GO:0032069)3.46532291
74negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.45396681
75neuron-neuron synaptic transmission (GO:0007270)3.45115560
76protein targeting to Golgi (GO:0000042)3.44616483
77cell communication involved in cardiac conduction (GO:0086065)3.44021488
78regulation of cAMP-dependent protein kinase activity (GO:2000479)3.41824685
79ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.41332396
80endoplasmic reticulum unfolded protein response (GO:0030968)3.35125006
81regulation of voltage-gated calcium channel activity (GO:1901385)3.32183078
82synaptic transmission, glutamatergic (GO:0035249)3.31556713
83epithelial cell fate commitment (GO:0072148)3.31134031
84cellular response to unfolded protein (GO:0034620)3.30667711
85regulation of peptide transport (GO:0090087)3.27199406
86cellular zinc ion homeostasis (GO:0006882)3.26774580
87neurotransmitter transport (GO:0006836)3.26639677
88regulation of glucocorticoid secretion (GO:2000849)3.26255788
89potassium ion homeostasis (GO:0055075)3.25825440
90negative regulation of hormone biosynthetic process (GO:0032353)3.24498294
91regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.23102261
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.22325643
93regulation of glucokinase activity (GO:0033131)3.22282314
94regulation of hexokinase activity (GO:1903299)3.22282314
95cellular response to topologically incorrect protein (GO:0035967)3.21890964
96ER-nucleus signaling pathway (GO:0006984)3.20211242
97glutamate receptor signaling pathway (GO:0007215)3.18834905
98cerebellar Purkinje cell differentiation (GO:0021702)3.17359490
99long-term synaptic potentiation (GO:0060291)3.15434008
100regulation of synaptic plasticity (GO:0048167)3.15385638
101toxin metabolic process (GO:0009404)3.13003515
102negative regulation of peptide hormone secretion (GO:0090278)3.12164183
103intraciliary transport (GO:0042073)3.10554434
104interleukin-1-mediated signaling pathway (GO:0070498)3.09579761
105cellular response to vitamin D (GO:0071305)3.09268492
106chemosensory behavior (GO:0007635)3.08158003
107regulation of vesicle fusion (GO:0031338)3.07923785
108negative regulation of bone resorption (GO:0045779)3.04477757
109cellular response to glucagon stimulus (GO:0071377)3.04375232
110hormone secretion (GO:0046879)3.03737963
111layer formation in cerebral cortex (GO:0021819)3.03655488
112relaxation of cardiac muscle (GO:0055119)3.03023276
113regulation of calcium ion-dependent exocytosis (GO:0017158)3.00924440
114neuromuscular process controlling balance (GO:0050885)3.00856276
115regulation of neurotransmitter secretion (GO:0046928)3.00789217
116protein N-linked glycosylation via asparagine (GO:0018279)3.00309053
117regulation of glutamate receptor signaling pathway (GO:1900449)2.99660771
118negative regulation of peptide secretion (GO:0002792)2.99566686
119relaxation of muscle (GO:0090075)2.98507875
120peptidyl-asparagine modification (GO:0018196)2.97297078
121neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.96938885
122ER to Golgi vesicle-mediated transport (GO:0006888)2.96341437
123establishment of protein localization to Golgi (GO:0072600)2.95322815
124dendritic spine morphogenesis (GO:0060997)2.95101761
125regulation of cell communication by electrical coupling (GO:0010649)2.94916075
126cochlea development (GO:0090102)2.94801616
127regulation of synaptic vesicle exocytosis (GO:2000300)2.94200251
128peptide transport (GO:0015833)2.93701840
129membrane depolarization during action potential (GO:0086010)2.93543799
130positive regulation of hormone secretion (GO:0046887)2.93140732
131cellular response to hepatocyte growth factor stimulus (GO:0035729)2.92709494
132response to hepatocyte growth factor (GO:0035728)2.92709494
133long-term memory (GO:0007616)2.92101853
134cerebellar Purkinje cell layer development (GO:0021680)2.92068639
135negative regulation of glycoprotein biosynthetic process (GO:0010561)2.89968541
136clathrin coat assembly (GO:0048268)2.89964384
137neurotransmitter uptake (GO:0001504)2.87541260
138hormone transport (GO:0009914)2.86780160
139macroautophagy (GO:0016236)2.86773575
140regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85522663
141response to endoplasmic reticulum stress (GO:0034976)2.85080854
142lactate metabolic process (GO:0006089)2.84988619
143negative regulation of hormone metabolic process (GO:0032351)2.84584610
144positive regulation of synapse maturation (GO:0090129)2.84228122
145regulation of Golgi to plasma membrane protein transport (GO:0042996)2.82584815
146retrograde transport, vesicle recycling within Golgi (GO:0000301)2.81974845
147cytoplasmic mRNA processing body assembly (GO:0033962)2.81895875
148L-alpha-amino acid transmembrane transport (GO:1902475)2.80939565
149Golgi organization (GO:0007030)2.80329842
150regulation of norepinephrine secretion (GO:0014061)2.80009408
151acidic amino acid transport (GO:0015800)2.79677441
152presynaptic membrane organization (GO:0097090)2.79571778
153phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.79290188
154astrocyte differentiation (GO:0048708)2.78945924
155positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.78555398
156negative regulation of glycogen biosynthetic process (GO:0045719)2.78450149
157regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78381241
158presynaptic membrane assembly (GO:0097105)2.77988617
159positive regulation of membrane potential (GO:0045838)2.76793216
160regulation of Rap GTPase activity (GO:0032317)2.75740030
161magnesium ion transport (GO:0015693)2.75453987
162protein localization to synapse (GO:0035418)2.73861895
163protein N-linked glycosylation (GO:0006487)2.73811988
164eosinophil chemotaxis (GO:0048245)2.71736882
165G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.71146426
166regulation of neurotransmitter transport (GO:0051588)2.70714101
167regulation of neurotransmitter levels (GO:0001505)2.70711319
168response to hexose (GO:0009746)2.70455412
169regulation of dendritic spine morphogenesis (GO:0061001)2.70300096
170positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.69772150
171response to glucose (GO:0009749)2.69405120
172positive regulation of exocytosis (GO:0045921)2.69119898
173activation of protein kinase A activity (GO:0034199)2.67626612
174neurofilament cytoskeleton organization (GO:0060052)2.67501364
175positive regulation of vesicle fusion (GO:0031340)2.67494368
176cellular response to ATP (GO:0071318)2.67284646
177positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.67269318
178vesicle transport along microtubule (GO:0047496)2.67005826
179induction of positive chemotaxis (GO:0050930)2.66928330
180purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.66261366
1813-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.66261366
182axonal fasciculation (GO:0007413)2.65778550
183positive regulation of Rap GTPase activity (GO:0032854)2.65747661
184regulation of postsynaptic membrane potential (GO:0060078)2.65089715
185negative regulation of neurotransmitter secretion (GO:0046929)2.63972609
186L-glutamate transport (GO:0015813)2.60228241
187cytoskeletal anchoring at plasma membrane (GO:0007016)2.60178116
188innervation (GO:0060384)2.58595387
189neuron cell-cell adhesion (GO:0007158)2.57952040
190positive regulation of dendritic spine development (GO:0060999)2.55676558
191cell differentiation in hindbrain (GO:0021533)2.54595690
192regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.54044843
193neurotransmitter-gated ion channel clustering (GO:0072578)2.53735019
194neuronal ion channel clustering (GO:0045161)2.52006228
195regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.51174706
196proline transport (GO:0015824)2.49975821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.70408678
2EZH2_22144423_ChIP-Seq_EOC_Human3.58120455
3GBX2_23144817_ChIP-Seq_PC3_Human3.26664553
4DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.62724121
5TAF15_26573619_Chip-Seq_HEK293_Human2.44626707
6IGF1R_20145208_ChIP-Seq_DFB_Human2.40030237
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.37351640
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.29379338
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17689661
10GATA1_22025678_ChIP-Seq_K562_Human2.12889263
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.06864688
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.02921340
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92169245
14POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91322527
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85177309
16SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78913753
17REST_18959480_ChIP-ChIP_MESCs_Mouse1.77153629
18PIAS1_25552417_ChIP-Seq_VCAP_Human1.77081448
19PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76605732
20TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.74347504
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.74326277
22STAT3_23295773_ChIP-Seq_U87_Human1.73788478
23EP300_21415370_ChIP-Seq_HL-1_Mouse1.72675437
24MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71700895
25SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.70338658
26CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69375692
27FUS_26573619_Chip-Seq_HEK293_Human1.66761732
28SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.66428326
29SMAD4_21799915_ChIP-Seq_A2780_Human1.66157970
30BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65787365
31RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65487326
32EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65487326
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61346618
34ZNF274_21170338_ChIP-Seq_K562_Hela1.59147301
35VDR_22108803_ChIP-Seq_LS180_Human1.58460368
36AR_21572438_ChIP-Seq_LNCaP_Human1.57465476
37FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56264963
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54629822
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.54072566
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50110646
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47727561
42SALL1_21062744_ChIP-ChIP_HESCs_Human1.46888425
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44399932
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44272315
45CTNNB1_20460455_ChIP-Seq_HCT116_Human1.43970870
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.43811936
47NANOG_18555785_Chip-Seq_ESCs_Mouse1.43369201
48OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40802674
49TCF4_23295773_ChIP-Seq_U87_Human1.40508280
50TP53_16413492_ChIP-PET_HCT116_Human1.39719230
51RARB_27405468_Chip-Seq_BRAIN_Mouse1.39116483
52P300_19829295_ChIP-Seq_ESCs_Human1.37953391
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36280980
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.35988485
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.34651863
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.34304959
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.33374048
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32399415
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32122682
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.30491689
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29217910
62SOX2_21211035_ChIP-Seq_LN229_Gbm1.28578257
63GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.27656176
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27521676
65DROSHA_22980978_ChIP-Seq_HELA_Human1.26283853
66STAT3_18555785_Chip-Seq_ESCs_Mouse1.25444188
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.24513800
68SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24424073
69AHR_22903824_ChIP-Seq_MCF-7_Human1.24266191
70LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23726396
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23186789
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23186789
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22272853
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22082343
75SOX9_26525672_Chip-Seq_HEART_Mouse1.21665728
76YAP1_20516196_ChIP-Seq_MESCs_Mouse1.19971848
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.19778683
78TP53_18474530_ChIP-ChIP_U2OS_Human1.18942977
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18697432
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17781026
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.16950537
82P53_22387025_ChIP-Seq_ESCs_Mouse1.16919786
83* REST_19997604_ChIP-ChIP_NEURONS_Mouse1.15793311
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.14590188
85SUZ12_27294783_Chip-Seq_ESCs_Mouse1.14520543
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14459249
87RNF2_27304074_Chip-Seq_ESCs_Mouse1.13321231
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.12783961
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12046244
90EED_16625203_ChIP-ChIP_MESCs_Mouse1.11866248
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.11842893
92RUNX2_22187159_ChIP-Seq_PCA_Human1.11757599
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.10425469
94RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09790718
95TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08989649
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08679363
97PRDM14_20953172_ChIP-Seq_ESCs_Human1.07257832
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07082913
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.06153450
100AR_19668381_ChIP-Seq_PC3_Human1.05358966
101BCAT_22108803_ChIP-Seq_LS180_Human1.05252998
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.04753634
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04498538
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.04126428
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03528783
106AR_25329375_ChIP-Seq_VCAP_Human1.02891449
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02591911
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02591911
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.02341795
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02299293
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02111828
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01897762
113SMAD3_21741376_ChIP-Seq_ESCs_Human1.01780581
114RNF2_27304074_Chip-Seq_NSC_Mouse1.00959807
115FLI1_27457419_Chip-Seq_LIVER_Mouse1.00682916
116TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00465345
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00161356
118KDM2B_26808549_Chip-Seq_REH_Human1.00051444
119SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.00026366
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99094583
121P300_18555785_Chip-Seq_ESCs_Mouse0.98871259
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98115203
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97225891
124PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96639179
125ESRRB_18555785_Chip-Seq_ESCs_Mouse0.94844548
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93865811
127TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93660172
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.93298251
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.93026011
130FLI1_21867929_ChIP-Seq_TH2_Mouse0.92936752
131KLF4_18555785_Chip-Seq_ESCs_Mouse0.92929763
132BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92867536
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.91442047
134SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91123817
135ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90738590
136ZFX_18555785_Chip-Seq_ESCs_Mouse0.89389164

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002877_abnormal_melanocyte_morpholog4.75082638
2MP0003283_abnormal_digestive_organ4.42620694
3MP0004043_abnormal_pH_regulation4.19443797
4MP0009780_abnormal_chondrocyte_physiolo4.11303410
5MP0003880_abnormal_central_pattern4.02557240
6MP0002693_abnormal_pancreas_physiology3.99659854
7MP0010386_abnormal_urinary_bladder3.68258333
8MP0002909_abnormal_adrenal_gland3.61533613
9MP0005379_endocrine/exocrine_gland_phen3.56565965
10MP0000013_abnormal_adipose_tissue3.45524849
11MP0001944_abnormal_pancreas_morphology3.42805125
12MP0009046_muscle_twitch2.97849394
13MP0000678_abnormal_parathyroid_gland2.93480463
14MP0005423_abnormal_somatic_nervous2.90589496
15MP0003183_abnormal_peptide_metabolism2.85110647
16MP0003195_calcinosis2.84900501
17MP0008057_abnormal_DNA_replication2.75260273
18MP0005646_abnormal_pituitary_gland2.69697625
19MP0006072_abnormal_retinal_apoptosis2.63861302
20MP0005645_abnormal_hypothalamus_physiol2.38218557
21MP0002837_dystrophic_cardiac_calcinosis2.33162872
22MP0001986_abnormal_taste_sensitivity2.24064455
23MP0002078_abnormal_glucose_homeostasis2.15422509
24MP0005220_abnormal_exocrine_pancreas2.15094836
25MP0002638_abnormal_pupillary_reflex2.06325160
26MP0004270_analgesia2.06053145
27MP0003122_maternal_imprinting1.96721112
28MP0010352_gastrointestinal_tract_polyps1.88755665
29MP0002735_abnormal_chemical_nociception1.80796100
30MP0000569_abnormal_digit_pigmentation1.74992247
31MP0000003_abnormal_adipose_tissue1.61113283
32MP0004215_abnormal_myocardial_fiber1.60079596
33MP0004264_abnormal_extraembryonic_tissu1.58355953
34MP0003690_abnormal_glial_cell1.55451459
35MP0000631_abnormal_neuroendocrine_gland1.52112605
36MP0002876_abnormal_thyroid_physiology1.51614094
37MP0001968_abnormal_touch/_nociception1.48709273
38MP0003329_amyloid_beta_deposits1.48554770
39MP0000778_abnormal_nervous_system1.47485422
40MP0003172_abnormal_lysosome_physiology1.46377262
41MP0004084_abnormal_cardiac_muscle1.44473837
42MP0001440_abnormal_grooming_behavior1.44214090
43MP0002234_abnormal_pharynx_morphology1.43992063
44MP0004811_abnormal_neuron_physiology1.43586060
45MP0010234_abnormal_vibrissa_follicle1.41482975
46MP0008877_abnormal_DNA_methylation1.40194190
47MP0000462_abnormal_digestive_system1.39856555
48MP0003868_abnormal_feces_composition1.39775760
49MP0003953_abnormal_hormone_level1.38107480
50MP0004036_abnormal_muscle_relaxation1.36664568
51MP0001177_atelectasis1.36166920
52MP0003635_abnormal_synaptic_transmissio1.30728353
53MP0001765_abnormal_ion_homeostasis1.28938840
54MP0002163_abnormal_gland_morphology1.27758611
55MP0002896_abnormal_bone_mineralization1.27022415
56MP0002066_abnormal_motor_capabilities/c1.26877366
57MP0000613_abnormal_salivary_gland1.25865008
58MP0002734_abnormal_mechanical_nocicepti1.25271280
59MP0003631_nervous_system_phenotype1.24063688
60MP0005535_abnormal_body_temperature1.23562688
61MP0004484_altered_response_of1.22824542
62MP0002928_abnormal_bile_duct1.22487672
63MP0008961_abnormal_basal_metabolism1.21360596
64MP0005253_abnormal_eye_physiology1.21148614
65MP0006292_abnormal_olfactory_placode1.20957116
66MP0003787_abnormal_imprinting1.19556082
67MP0001502_abnormal_circadian_rhythm1.18101555
68MP0003890_abnormal_embryonic-extraembry1.17616824
69MP0000751_myopathy1.17205418
70MP0001188_hyperpigmentation1.15065984
71MP0005623_abnormal_meninges_morphology1.14963048
72MP0002882_abnormal_neuron_morphology1.13373077
73MP0003632_abnormal_nervous_system1.12557696
74MP0002733_abnormal_thermal_nociception1.12201816
75MP0002572_abnormal_emotion/affect_behav1.10305536
76MP0001348_abnormal_lacrimal_gland1.08444410
77MP0003119_abnormal_digestive_system1.04299370
78MP0000920_abnormal_myelination1.02710198
79MP0002272_abnormal_nervous_system1.01189302
80MP0002822_catalepsy1.01021040
81MP0000681_abnormal_thyroid_gland1.00443312
82MP0002063_abnormal_learning/memory/cond0.99432486
83MP0004885_abnormal_endolymph0.99307701
84MP0005171_absent_coat_pigmentation0.98957492
85MP0005310_abnormal_salivary_gland0.98426635
86MP0008874_decreased_physiological_sensi0.97328762
87MP0001501_abnormal_sleep_pattern0.92940857
88MP0002152_abnormal_brain_morphology0.92723271
89MP0001970_abnormal_pain_threshold0.91457005
90MP0003091_abnormal_cell_migration0.91194371
91MP0004859_abnormal_synaptic_plasticity0.91115785
92MP0006276_abnormal_autonomic_nervous0.90630989
93MP0004510_myositis0.89841977
94MP0003879_abnormal_hair_cell0.89672460
95MP0002557_abnormal_social/conspecific_i0.89310731
96MP0000955_abnormal_spinal_cord0.88762419
97MP0000538_abnormal_urinary_bladder0.88229084
98MP0005620_abnormal_muscle_contractility0.87580202
99MP0009745_abnormal_behavioral_response0.84791928
100MP0002064_seizures0.84708000
101MP0000639_abnormal_adrenal_gland0.83849797
102MP0003959_abnormal_lean_body0.82946367
103MP0005448_abnormal_energy_balance0.81981776
104MP0003252_abnormal_bile_duct0.81940173
105MP0005058_abnormal_lysosome_morphology0.81691758
106MP0004145_abnormal_muscle_electrophysio0.81507701
107MP0001299_abnormal_eye_distance/0.81144262
108MP0005257_abnormal_intraocular_pressure0.79684240
109MP0004085_abnormal_heartbeat0.79298507
110MP0001270_distended_abdomen0.78882523
111MP0002009_preneoplasia0.78538716
112MP0001905_abnormal_dopamine_level0.77424461
113MP0003045_fibrosis0.76998439
114MP0002069_abnormal_eating/drinking_beha0.74659262
115MP0005248_abnormal_Harderian_gland0.73921622
116MP0004130_abnormal_muscle_cell0.73757103
117MP0001984_abnormal_olfaction0.71482412
118MP0001943_abnormal_respiration0.71481309
119MP0002736_abnormal_nociception_after0.70101912
120MP0001963_abnormal_hearing_physiology0.69730433
121MP0001661_extended_life_span0.69045102
122MP0002067_abnormal_sensory_capabilities0.68932844
123MP0000428_abnormal_craniofacial_morphol0.68122604
124MP0005275_abnormal_skin_tensile0.68011578
125MP0001486_abnormal_startle_reflex0.67880804
126MP0005365_abnormal_bile_salt0.66855142
127MP0002229_neurodegeneration0.66712618
128MP0005551_abnormal_eye_electrophysiolog0.66613497
129MP0009672_abnormal_birth_weight0.66587839
130MP0000230_abnormal_systemic_arterial0.66321228
131MP0009643_abnormal_urine_homeostasis0.65237860
132MP0002972_abnormal_cardiac_muscle0.64971953
133MP0001186_pigmentation_phenotype0.62963673
134MP0005636_abnormal_mineral_homeostasis0.62249246
135MP0005187_abnormal_penis_morphology0.62098311
136MP0010769_abnormal_survival0.61189960
137MP0001346_abnormal_lacrimal_gland0.60793766
138MP0002177_abnormal_outer_ear0.60646506
139MP0003300_gastrointestinal_ulcer0.60320325
140MP0003633_abnormal_nervous_system0.60071910
141MP0003634_abnormal_glial_cell0.59015510
142MP0003121_genomic_imprinting0.58332516
143MP0002751_abnormal_autonomic_nervous0.58101703
144MP0004087_abnormal_muscle_fiber0.57960960
145MP0002082_postnatal_lethality0.57646437
146MP0010770_preweaning_lethality0.57646437
147MP0001664_abnormal_digestion0.57237318
148MP0004924_abnormal_behavior0.57117231
149MP0005386_behavior/neurological_phenoty0.57117231
150MP0010768_mortality/aging0.56877534
151MP0002184_abnormal_innervation0.56174968
152MP0008569_lethality_at_weaning0.55388514

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)7.59574272
2Hypoglycemic seizures (HP:0002173)6.84116851
3Symptomatic seizures (HP:0011145)6.26053085
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.02282264
5Insulin-resistant diabetes mellitus (HP:0000831)5.22662051
6Febrile seizures (HP:0002373)5.13858249
7Hypoglycemic coma (HP:0001325)5.07285986
8Pancreatic islet-cell hyperplasia (HP:0004510)4.80911223
9Hyperglycemia (HP:0003074)4.77585138
10Focal seizures (HP:0007359)4.66953494
11Decreased circulating renin level (HP:0003351)4.65979029
12Abnormality of endocrine pancreas physiology (HP:0012093)4.55576398
13Abnormality of the pancreatic islet cells (HP:0006476)4.55576398
14Large for gestational age (HP:0001520)4.43186898
15Abnormality of calcium-phosphate metabolism (HP:0100530)4.19930970
16Myokymia (HP:0002411)4.12047262
17Ketoacidosis (HP:0001993)3.99563219
18Epileptic encephalopathy (HP:0200134)3.67952526
19Action tremor (HP:0002345)3.67773281
20Hypokalemia (HP:0002900)3.50883666
21Osteomalacia (HP:0002749)3.48260779
22Conjugated hyperbilirubinemia (HP:0002908)3.47247814
23Abnormal pancreas size (HP:0012094)3.46100043
24Mucopolysacchariduria (HP:0008155)3.44461629
25Urinary glycosaminoglycan excretion (HP:0003541)3.44461629
26Dialeptic seizures (HP:0011146)3.44408293
27Hypothermia (HP:0002045)3.40702926
28Generalized tonic-clonic seizures (HP:0002069)3.31348085
29Late onset (HP:0003584)3.21693171
30Truncal ataxia (HP:0002078)3.20625287
31Abnormality of polysaccharide metabolism (HP:0011012)3.20117519
32Abnormality of glycosaminoglycan metabolism (HP:0004371)3.20117519
33Abnormality of mucopolysaccharide metabolism (HP:0011020)3.20117519
34Diplopia (HP:0000651)3.07812512
35Abnormality of binocular vision (HP:0011514)3.07812512
36Supranuclear gaze palsy (HP:0000605)3.07113295
37Abnormality of renin-angiotensin system (HP:0000847)3.06345918
38Dysostosis multiplex (HP:0000943)3.06333378
39Agitation (HP:0000713)3.02793234
40Abnormality of the corticospinal tract (HP:0002492)2.99802624
41Hemiparesis (HP:0001269)2.93848271
42EEG with generalized epileptiform discharges (HP:0011198)2.89328418
43Bundle branch block (HP:0011710)2.88132934
44Ankle clonus (HP:0011448)2.87195426
45Hypoplasia of the fovea (HP:0007750)2.86614119
46Aplasia/Hypoplasia of the fovea (HP:0008060)2.86614119
47Abnormality of potassium homeostasis (HP:0011042)2.84444931
48Epileptiform EEG discharges (HP:0011182)2.83532808
49Hypsarrhythmia (HP:0002521)2.80290917
50Spastic gait (HP:0002064)2.76449355
51Progressive cerebellar ataxia (HP:0002073)2.76007568
52Generalized aminoaciduria (HP:0002909)2.75951341
53Hyperkalemia (HP:0002153)2.74662230
54Abnormality of the intrinsic pathway (HP:0010989)2.71235823
55Obstructive sleep apnea (HP:0002870)2.70658764
56Hyperactive renin-angiotensin system (HP:0000841)2.69286042
57Abnormality of the fovea (HP:0000493)2.66856441
58Degeneration of the lateral corticospinal tracts (HP:0002314)2.65399201
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.65399201
60Overgrowth (HP:0001548)2.63808063
61Retinal atrophy (HP:0001105)2.60951108
62Dysmetric saccades (HP:0000641)2.60658777
63Gaze-evoked nystagmus (HP:0000640)2.60390849
64Insulin resistance (HP:0000855)2.57513668
65Neurofibrillary tangles (HP:0002185)2.57510817
66Lower limb muscle weakness (HP:0007340)2.54706329
67Impaired vibration sensation in the lower limbs (HP:0002166)2.54379413
68Visual hallucinations (HP:0002367)2.51950282
69Prominent metopic ridge (HP:0005487)2.50798333
70Urinary bladder sphincter dysfunction (HP:0002839)2.49997200
71Hyperparathyroidism (HP:0000843)2.47979980
72Dysautonomia (HP:0002459)2.47261469
73Intestinal atresia (HP:0011100)2.43808347
74Unilateral renal agenesis (HP:0000122)2.43000890
75Chronic bronchitis (HP:0004469)2.37241170
76Cerebral inclusion bodies (HP:0100314)2.36691177
77Urinary urgency (HP:0000012)2.36302709
78Postural instability (HP:0002172)2.32778599
79Papilledema (HP:0001085)2.31850977
80Increased circulating renin level (HP:0000848)2.29207755
81Cortical visual impairment (HP:0100704)2.28799176
82Abnormal eating behavior (HP:0100738)2.28348566
83Thickened helices (HP:0000391)2.26024943
84Tetraplegia (HP:0002445)2.23545059
85Mild short stature (HP:0003502)2.23414067
86Dysmetria (HP:0001310)2.20161204
87Scanning speech (HP:0002168)2.19662402
88Pheochromocytoma (HP:0002666)2.18708886
89Abnormality of the metopic suture (HP:0005556)2.18353923
90Limb hypertonia (HP:0002509)2.17041288
91Abnormality of the lower motor neuron (HP:0002366)2.15190370
92Sudden death (HP:0001699)2.11420165
93Intention tremor (HP:0002080)2.10196467
94Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.08016888
95Anxiety (HP:0000739)2.07799588
96Abnormal hair whorl (HP:0010721)2.07322294
97Atonic seizures (HP:0010819)2.06459100
98Cystic liver disease (HP:0006706)2.06293108
99Metaphyseal dysplasia (HP:0100255)2.04770625
100Hemiplegia (HP:0002301)2.04079780
101Status epilepticus (HP:0002133)2.03676747
102Menstrual irregularities (HP:0000858)2.03188982
103Hypokalemic alkalosis (HP:0001949)2.02769096
104Impaired vibratory sensation (HP:0002495)2.00387618
105Abnormality of ocular smooth pursuit (HP:0000617)2.00165665
106Abnormality of the left ventricular outflow tract (HP:0011103)1.99521606
107Subaortic stenosis (HP:0001682)1.99521606
108Impaired smooth pursuit (HP:0007772)1.99034142
109Bifid tongue (HP:0010297)1.98945568
110Absent eyebrow (HP:0002223)1.96739660
111Congenital glaucoma (HP:0001087)1.96160811
112Megalencephaly (HP:0001355)1.95969760
113Drooling (HP:0002307)1.95510158
114Hyporeflexia of lower limbs (HP:0002600)1.95444864
115Anteriorly placed anus (HP:0001545)1.94202290
116Medial flaring of the eyebrow (HP:0010747)1.94166400
117Atrial fibrillation (HP:0005110)1.93824045
118Failure to thrive in infancy (HP:0001531)1.92645067
119Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.92498673
120Hypotension (HP:0002615)1.91571263
121Poor eye contact (HP:0000817)1.91402876
122Amblyopia (HP:0000646)1.91142088
123Sleep apnea (HP:0010535)1.90507527
124Abnormality of chloride homeostasis (HP:0011422)1.89849089
125Heart block (HP:0012722)1.89660615
126Oligomenorrhea (HP:0000876)1.88872558
127Ketosis (HP:0001946)1.88267724
128Resting tremor (HP:0002322)1.88001158
129Aplasia of the phalanges of the hand (HP:0009802)1.87881127
130Aplasia involving bones of the extremities (HP:0009825)1.87881127
131Aplasia involving bones of the upper limbs (HP:0009823)1.87881127
132Excessive salivation (HP:0003781)1.87096599
133Congenital primary aphakia (HP:0007707)1.86497332
134Exocrine pancreatic insufficiency (HP:0001738)1.86173757
135Gait imbalance (HP:0002141)1.85780505
136Torticollis (HP:0000473)1.85447474
137Progressive neurologic deterioration (HP:0002344)1.84897471
138Spastic paraplegia (HP:0001258)1.84771732
139Atrioventricular block (HP:0001678)1.83963625
140Cubitus valgus (HP:0002967)1.83803603
141Paraplegia (HP:0010550)1.82833419
142Restlessness (HP:0000711)1.81467782
143Fetal akinesia sequence (HP:0001989)1.81440691
144Spastic tetraparesis (HP:0001285)1.81094892
145Thyroid carcinoma (HP:0002890)1.80288941
146Neuroendocrine neoplasm (HP:0100634)1.80037786
147Syncope (HP:0001279)1.79454401
148Congenital sensorineural hearing impairment (HP:0008527)1.77588785
149Disproportionate short-trunk short stature (HP:0003521)1.76889882
150Primary atrial arrhythmia (HP:0001692)1.76598746
151Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75723128
152Deeply set eye (HP:0000490)1.75354008
153Thoracolumbar scoliosis (HP:0002944)1.74354964
154Depression (HP:0000716)1.73749540
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73425272
156Abnormal protein N-linked glycosylation (HP:0012347)1.73425272
157Abnormal protein glycosylation (HP:0012346)1.73425272
158Abnormal glycosylation (HP:0012345)1.73425272
159Lower limb asymmetry (HP:0100559)1.73378879
160Abnormal atrioventricular conduction (HP:0005150)1.72991663
161Impaired social interactions (HP:0000735)1.72420886
162Abnormal social behavior (HP:0012433)1.72420886
163Apathy (HP:0000741)1.72176493
164Rapidly progressive (HP:0003678)1.71891731
165Bradykinesia (HP:0002067)1.71662690
166Abdominal distention (HP:0003270)1.71371281
167Nephrogenic diabetes insipidus (HP:0009806)1.71093978
168Macroorchidism (HP:0000053)1.70879644
169Hypophosphatemia (HP:0002148)1.70589875
170Aplasia/Hypoplasia of the macula (HP:0008059)1.70454541
171Hyperventilation (HP:0002883)1.70396894
172Sensory axonal neuropathy (HP:0003390)1.69982074
173Papillary thyroid carcinoma (HP:0002895)1.69645791
174Postural tremor (HP:0002174)1.69312412
175Hyperphosphaturia (HP:0003109)1.68896923
176Neoplasm of the heart (HP:0100544)1.68564349
177Focal motor seizures (HP:0011153)1.67750185
178Hyperaldosteronism (HP:0000859)1.65620830
179Hyperphosphatemia (HP:0002905)1.65404460
180Glucose intolerance (HP:0000833)1.65092106
181Aplasia/hypoplasia of the uterus (HP:0008684)1.64846005
182Median cleft lip (HP:0000161)1.63123872
183Aplasia/Hypoplasia affecting the retina (HP:0008061)1.61901601
184Adrenal overactivity (HP:0002717)1.60817980
185Absence seizures (HP:0002121)1.59047016
186Type II diabetes mellitus (HP:0005978)1.58208490
187Muscular hypotonia of the trunk (HP:0008936)1.57322216

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR7.54533269
2PASK4.40800868
3MAP3K94.26779511
4MAPK153.58822232
5PRKD33.52226496
6TAOK33.31126224
7FRK2.97651779
8AKT32.86393869
9HIPK22.81099452
10NTRK32.69341411
11LATS12.57461232
12MAP3K22.48586401
13ARAF2.33688277
14PAK62.32689100
15IRAK32.14648796
16MAP3K132.14373582
17DAPK22.11155082
18NTRK22.10985651
19CDC42BPA2.03645951
20KSR21.95416806
21UHMK11.94590431
22WNK31.88801647
23LATS21.74966839
24WNK41.65564064
25CAMKK21.63780904
26NTRK11.50022313
27MAP3K11.46995397
28IRAK11.39984567
29CASK1.37135184
30PRKD21.27612321
31CDK191.27383143
32PHKG11.22754986
33PHKG21.22754986
34PRKCH1.22313554
35KSR11.20503973
36STK31.19076624
37FGFR21.16653573
38BRD41.16203384
39PLK21.14935003
40STK381.14848962
41IRAK21.12484333
42CAMK11.09965722
43BMPR21.08965629
44PDGFRA1.07450055
45FLT31.05809845
46OBSCN1.00512236
47SGK20.98432833
48SCYL20.96712619
49MAP3K40.96335817
50STK110.95994598
51TNIK0.94690833
52MAP2K70.94513355
53PNCK0.92337805
54PRKCE0.87438214
55BRAF0.85975138
56MOS0.85936323
57RAF10.85493917
58WNK10.84963866
59CAMK40.82493068
60SGK2230.82162797
61SGK4940.82162797
62PAK30.82019605
63PDK10.81961466
64FGFR30.81869632
65BRSK20.80471520
66NEK60.79346006
67OXSR10.77420559
68ERBB30.77059580
69STK240.76919059
70MAP3K60.73602554
71STK38L0.71874657
72CAMK2D0.71686554
73PTK20.70648266
74EIF2AK30.70566450
75YES10.70533254
76EPHA30.69502107
77MAPK120.65852805
78RPS6KB10.65824133
79PDPK10.63773999
80PINK10.63466212
81MAPK130.62550106
82PRKAA10.62409276
83CAMK2B0.61819361
84TRPM70.59943479
85RPS6KA20.59891437
86LMTK20.59065101
87SGK30.58209544
88SGK10.57723747
89DMPK0.56254837
90CDK50.56175127
91RIPK10.55874988
92TTN0.55511840
93MET0.53999456
94BCR0.53857477
95RET0.52312552
96IRAK40.52015945
97CSNK1A10.51732204
98DYRK1B0.50549846
99ICK0.50152745
100MAP3K100.49211909
101FER0.48642493
102JAK10.48366912
103BMPR1B0.48350285
104CDK150.47607986
105SIK20.47522380
106MAPK70.46854496
107CAMK2G0.46298069
108ALK0.45987129
109MARK10.45843489
110PTK2B0.45265660
111ROCK20.45176208
112CDK180.45030806
113DYRK1A0.43664137
114CAMK2A0.43547894
115PRKCI0.43541483
116GRK50.43118696
117CDK140.42643240
118PRKACA0.41896197
119CSNK1A1L0.41182031
120PRKCZ0.41020097
121CDK30.40723993
122MAP2K40.39864302
123PRKCG0.39841389
124PRKACG0.39826224
125ADRBK10.39538162
126CAMKK10.38719194
127GSK3A0.38342844
128PIK3CG0.38044335
129PTK60.37240412
130JAK20.36323452
131MELK0.35251376
132MARK20.35017131
133RPS6KA30.34752302
134MAPK100.32002554
135PRKDC0.30467995
136MINK10.30319780
137EPHA40.30297245
138BRSK10.30283719
139PRKD10.30149652
140MAPK140.29805495
141NLK0.29033435
142PRKG10.28143253
143CSNK1G20.28035451
144PRKCA0.27006089
145ERN10.23186614
146PRPF4B0.23164009
147CAMK1G0.23112684
148PRKCB0.22673059
149IGF1R0.22086214

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.49623775
2Protein export_Homo sapiens_hsa030605.04429055
3Insulin secretion_Homo sapiens_hsa049113.58238497
4Sulfur metabolism_Homo sapiens_hsa009203.10592100
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.61973317
6Type II diabetes mellitus_Homo sapiens_hsa049302.34784833
7Type I diabetes mellitus_Homo sapiens_hsa049402.28090197
8Vibrio cholerae infection_Homo sapiens_hsa051101.94353111
9Cocaine addiction_Homo sapiens_hsa050301.84009309
10Taste transduction_Homo sapiens_hsa047421.82892400
11Amphetamine addiction_Homo sapiens_hsa050311.69416915
12Carbohydrate digestion and absorption_Homo sapiens_hsa049731.68322406
13GABAergic synapse_Homo sapiens_hsa047271.52250875
14Glioma_Homo sapiens_hsa052141.48008489
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38524247
16Circadian rhythm_Homo sapiens_hsa047101.37107112
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35506421
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35453311
19N-Glycan biosynthesis_Homo sapiens_hsa005101.35258728
20Synaptic vesicle cycle_Homo sapiens_hsa047211.35214621
21Long-term potentiation_Homo sapiens_hsa047201.30769025
22Circadian entrainment_Homo sapiens_hsa047131.30454892
23Dilated cardiomyopathy_Homo sapiens_hsa054141.29301910
24Morphine addiction_Homo sapiens_hsa050321.27778920
25Serotonergic synapse_Homo sapiens_hsa047261.26826614
26Dopaminergic synapse_Homo sapiens_hsa047281.23574311
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22011058
28ErbB signaling pathway_Homo sapiens_hsa040121.21632730
29Collecting duct acid secretion_Homo sapiens_hsa049661.20714174
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17485218
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.17158310
32Endometrial cancer_Homo sapiens_hsa052131.16318677
33Cholinergic synapse_Homo sapiens_hsa047251.13986040
34Pancreatic secretion_Homo sapiens_hsa049721.12938822
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12777648
36Regulation of autophagy_Homo sapiens_hsa041401.12665116
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09744712
38Selenocompound metabolism_Homo sapiens_hsa004501.08089786
39Glucagon signaling pathway_Homo sapiens_hsa049221.07035201
40Thyroid hormone synthesis_Homo sapiens_hsa049181.05639271
41Lysosome_Homo sapiens_hsa041421.05132339
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01391985
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.98259200
44Nicotine addiction_Homo sapiens_hsa050330.95980812
45Glutamatergic synapse_Homo sapiens_hsa047240.95324910
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.91680005
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91220415
48Choline metabolism in cancer_Homo sapiens_hsa052310.89314909
49Colorectal cancer_Homo sapiens_hsa052100.89252226
50Renin secretion_Homo sapiens_hsa049240.88183567
51Oocyte meiosis_Homo sapiens_hsa041140.86217159
52Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85939170
53Renal cell carcinoma_Homo sapiens_hsa052110.85229715
54Rap1 signaling pathway_Homo sapiens_hsa040150.84866424
55Ras signaling pathway_Homo sapiens_hsa040140.81533322
56Non-small cell lung cancer_Homo sapiens_hsa052230.81220548
57VEGF signaling pathway_Homo sapiens_hsa043700.79831532
58Adherens junction_Homo sapiens_hsa045200.79511507
59Tight junction_Homo sapiens_hsa045300.74851241
60Prolactin signaling pathway_Homo sapiens_hsa049170.74625290
61Estrogen signaling pathway_Homo sapiens_hsa049150.74493892
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74173832
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74089284
64Dorso-ventral axis formation_Homo sapiens_hsa043200.73722252
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.73468663
66Insulin resistance_Homo sapiens_hsa049310.73259848
67Focal adhesion_Homo sapiens_hsa045100.72277350
68Sphingolipid metabolism_Homo sapiens_hsa006000.71447500
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.71279097
70ABC transporters_Homo sapiens_hsa020100.71176621
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.70585699
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69780346
73cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67510865
74Axon guidance_Homo sapiens_hsa043600.66347742
75Prion diseases_Homo sapiens_hsa050200.65883297
76Melanoma_Homo sapiens_hsa052180.64251346
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64233528
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63851693
79Hippo signaling pathway_Homo sapiens_hsa043900.62734586
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62467570
81Olfactory transduction_Homo sapiens_hsa047400.62037036
82Butanoate metabolism_Homo sapiens_hsa006500.61790197
83Vitamin B6 metabolism_Homo sapiens_hsa007500.60619089
84Proteoglycans in cancer_Homo sapiens_hsa052050.60370756
85Long-term depression_Homo sapiens_hsa047300.59169290
86cAMP signaling pathway_Homo sapiens_hsa040240.59084617
87Platelet activation_Homo sapiens_hsa046110.58131836
88Other glycan degradation_Homo sapiens_hsa005110.56362179
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55614616
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52882335
91Inositol phosphate metabolism_Homo sapiens_hsa005620.52326008
92Linoleic acid metabolism_Homo sapiens_hsa005910.52315033
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52045151
94Alcoholism_Homo sapiens_hsa050340.51951349
95Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51302434
96mTOR signaling pathway_Homo sapiens_hsa041500.49860656
97Salivary secretion_Homo sapiens_hsa049700.49796868
98Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49768627
99Bile secretion_Homo sapiens_hsa049760.48881954
100Galactose metabolism_Homo sapiens_hsa000520.48794578
101ECM-receptor interaction_Homo sapiens_hsa045120.47819437
102AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47637436
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.47593074
104Insulin signaling pathway_Homo sapiens_hsa049100.47514700
105Gastric acid secretion_Homo sapiens_hsa049710.45850887
106Melanogenesis_Homo sapiens_hsa049160.45532111
107Gap junction_Homo sapiens_hsa045400.44486195
108Ovarian steroidogenesis_Homo sapiens_hsa049130.44241909
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.44091691
110Pancreatic cancer_Homo sapiens_hsa052120.43999436
111Folate biosynthesis_Homo sapiens_hsa007900.43320236
112B cell receptor signaling pathway_Homo sapiens_hsa046620.41631318
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40681040
114Tryptophan metabolism_Homo sapiens_hsa003800.40511063
115GnRH signaling pathway_Homo sapiens_hsa049120.39611714
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.39077366
117Cardiac muscle contraction_Homo sapiens_hsa042600.39043391
118Chronic myeloid leukemia_Homo sapiens_hsa052200.38431460
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37613050
120Starch and sucrose metabolism_Homo sapiens_hsa005000.36378774
121Calcium signaling pathway_Homo sapiens_hsa040200.36154922
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35157818
123Prostate cancer_Homo sapiens_hsa052150.35005391
124Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34787219
125Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31015053
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28933830
127Oxytocin signaling pathway_Homo sapiens_hsa049210.27011879
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26035784
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.25845569
130MAPK signaling pathway_Homo sapiens_hsa040100.23193087
131FoxO signaling pathway_Homo sapiens_hsa040680.21383524
132Wnt signaling pathway_Homo sapiens_hsa043100.21146806
133Phenylalanine metabolism_Homo sapiens_hsa003600.20825643
134AMPK signaling pathway_Homo sapiens_hsa041520.20805086
135Ether lipid metabolism_Homo sapiens_hsa005650.20607723
136Hedgehog signaling pathway_Homo sapiens_hsa043400.18666874
137Protein digestion and absorption_Homo sapiens_hsa049740.16625398
138Phagosome_Homo sapiens_hsa041450.15835342
139Alzheimers disease_Homo sapiens_hsa050100.15461821

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »