CHFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.19915001
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.19915001
3modulation by symbiont of host immune response (GO:0052553)4.19915001
4positive regulation by symbiont of host defense response (GO:0052509)4.19915001
5modulation by symbiont of host defense response (GO:0052031)4.19915001
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.19915001
7negative regulation of interleukin-12 production (GO:0032695)4.19622985
8dosage compensation (GO:0007549)4.14419798
9cellular extravasation (GO:0045123)4.12486699
10regulation of B cell receptor signaling pathway (GO:0050855)4.07501498
11regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.03757910
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.97147162
13positive regulation of gamma-delta T cell activation (GO:0046645)3.81725493
14negative regulation of histone methylation (GO:0031061)3.79518623
15activated T cell proliferation (GO:0050798)3.76241512
16macrophage activation involved in immune response (GO:0002281)3.75239433
17nuclear pore complex assembly (GO:0051292)3.63337586
18negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.61420857
19negative regulation of cell killing (GO:0031342)3.61420857
20response to peptidoglycan (GO:0032494)3.52240346
21protein localization to kinetochore (GO:0034501)3.39266110
22detection of other organism (GO:0098543)3.33567074
23histone H2A acetylation (GO:0043968)3.33163285
24neutrophil activation involved in immune response (GO:0002283)3.32674377
25negative regulation of T cell mediated immunity (GO:0002710)3.32113382
26mitotic nuclear envelope disassembly (GO:0007077)3.31553342
27tolerance induction (GO:0002507)3.31215292
28negative regulation of gene expression, epigenetic (GO:0045814)3.30481939
29immunoglobulin mediated immune response (GO:0016064)3.24035075
30response to muramyl dipeptide (GO:0032495)3.22941276
31detection of bacterium (GO:0016045)3.22247294
32negative T cell selection (GO:0043383)3.22092455
33nuclear pore organization (GO:0006999)3.21412635
34protein localization to chromosome, centromeric region (GO:0071459)3.20853329
35actin nucleation (GO:0045010)3.19498659
36myeloid cell activation involved in immune response (GO:0002275)3.19423569
37membrane disassembly (GO:0030397)3.19305765
38nuclear envelope disassembly (GO:0051081)3.19305765
39microglial cell activation (GO:0001774)3.16773227
40defense response to protozoan (GO:0042832)3.16318705
41response to interleukin-15 (GO:0070672)3.15603560
42negative regulation of lymphocyte mediated immunity (GO:0002707)3.15384784
43positive regulation of antigen processing and presentation (GO:0002579)3.14611416
44mitotic chromosome condensation (GO:0007076)3.14541252
45leukocyte aggregation (GO:0070486)3.14379677
46response to type I interferon (GO:0034340)3.13601639
47negative thymic T cell selection (GO:0045060)3.12693463
48regulation of mast cell activation (GO:0033003)3.12592268
49regulation of antigen processing and presentation (GO:0002577)3.11756586
50response to protozoan (GO:0001562)3.08486459
51regulation of dendritic cell antigen processing and presentation (GO:0002604)3.07627418
52regulation of interferon-beta biosynthetic process (GO:0045357)3.06377836
53cellular response to interleukin-15 (GO:0071350)3.05526709
54cellular response to type I interferon (GO:0071357)3.04381302
55type I interferon signaling pathway (GO:0060337)3.04381302
56regulation of histone H3-K9 methylation (GO:0051570)3.03027515
57pore complex assembly (GO:0046931)3.03004376
58positive thymic T cell selection (GO:0045059)3.02082643
59positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.01454917
60regulation of mast cell degranulation (GO:0043304)3.01062807
61negative regulation of interleukin-6 production (GO:0032715)2.97790021
62histone H3-K36 demethylation (GO:0070544)2.93868875
63respiratory burst (GO:0045730)2.92936771
64mast cell activation (GO:0045576)2.92716733
65B cell receptor signaling pathway (GO:0050853)2.92593449
66interferon-gamma-mediated signaling pathway (GO:0060333)2.90651130
67activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.90199109
68neutrophil activation (GO:0042119)2.90100532
69histone H3-K4 trimethylation (GO:0080182)2.89529074
70regulation of B cell differentiation (GO:0045577)2.89448845
71nucleosome disassembly (GO:0006337)2.89031744
72protein-DNA complex disassembly (GO:0032986)2.89031744
73regulation of interleukin-12 biosynthetic process (GO:0045075)2.88776271
74sister chromatid segregation (GO:0000819)2.87701091
75regulation of mast cell activation involved in immune response (GO:0033006)2.87396254
76regulation of gamma-delta T cell differentiation (GO:0045586)2.85436771
77positive regulation of mast cell activation (GO:0033005)2.84929045
78regulation of T cell mediated cytotoxicity (GO:0001914)2.84732733
79leukocyte degranulation (GO:0043299)2.84705270
80negative regulation of interleukin-1 production (GO:0032692)2.84408372
81regulation of chromatin binding (GO:0035561)2.84403076
82nuclear envelope organization (GO:0006998)2.83752632
83macrophage activation (GO:0042116)2.83530616
84mannose metabolic process (GO:0006013)2.79534151
85regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.79150775
86negative regulation of leukocyte mediated immunity (GO:0002704)2.78882565
87neutrophil mediated immunity (GO:0002446)2.78731487
88granulocyte activation (GO:0036230)2.78521654
89germinal center formation (GO:0002467)2.77261554
90detection of external biotic stimulus (GO:0098581)2.76619257
91positive regulation of T cell mediated cytotoxicity (GO:0001916)2.75954654
92response to host immune response (GO:0052572)2.75836849
93response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.75836849
94regulation of T cell tolerance induction (GO:0002664)2.75348801
95positive regulation of chromosome segregation (GO:0051984)2.74414976
96antigen processing and presentation of endogenous antigen (GO:0019883)2.74393162
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.73608096
98positive regulation of defense response to virus by host (GO:0002230)2.71555437
99regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71235908
100regulation of gamma-delta T cell activation (GO:0046643)2.70670506
101regulation of RNA export from nucleus (GO:0046831)2.69967143
102pre-miRNA processing (GO:0031054)2.69690375
103thymic T cell selection (GO:0045061)2.68536681
104regulation of tolerance induction (GO:0002643)2.68062616
105mitotic sister chromatid segregation (GO:0000070)2.67855761
106regulation of NFAT protein import into nucleus (GO:0051532)2.67756436
107mast cell activation involved in immune response (GO:0002279)2.66581542
108mast cell degranulation (GO:0043303)2.66581542
109regulation of telomere maintenance via telomerase (GO:0032210)2.65880849
110mitotic sister chromatid cohesion (GO:0007064)2.65371556
111V(D)J recombination (GO:0033151)2.64880268
112histone H2A monoubiquitination (GO:0035518)2.64820259
113positive regulation of granulocyte differentiation (GO:0030854)2.64590825
114antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.64208750
115antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64208750
116negative regulation of interleukin-1 beta production (GO:0032691)2.63530300
117mitotic cytokinesis (GO:0000281)2.63518748
118T cell selection (GO:0045058)2.62018909
119detection of biotic stimulus (GO:0009595)2.61631843
120detection of molecule of bacterial origin (GO:0032490)2.61454714
121histone H3-K4 methylation (GO:0051568)2.60559588
122negative regulation of innate immune response (GO:0045824)2.59848168
123positive T cell selection (GO:0043368)2.59572209
124positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.59488379
125protein localization to chromosome (GO:0034502)2.59487843
126positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59170660
127regulation of natural killer cell mediated immunity (GO:0002715)2.57585656
128regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.57585656
129regulation of sister chromatid cohesion (GO:0007063)2.57543599
130DNA unwinding involved in DNA replication (GO:0006268)2.56984959
131regulation of myeloid leukocyte mediated immunity (GO:0002886)2.56891161
132regulation of interleukin-12 production (GO:0032655)2.56832045
133gene silencing by RNA (GO:0031047)2.56140556
134cytoskeleton-dependent cytokinesis (GO:0061640)2.55595108
135regulation of protein heterodimerization activity (GO:0043497)2.54095094
136translesion synthesis (GO:0019985)2.52954381
137T cell migration (GO:0072678)2.52882883
138histone H3-K9 demethylation (GO:0033169)2.50718970
139antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.49666761
140establishment of chromosome localization (GO:0051303)2.48417156
141regulation of chromosome segregation (GO:0051983)2.47619993
142positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.47340617
143DNA geometric change (GO:0032392)2.45331333
144sequestering of actin monomers (GO:0042989)2.44885495
145B cell homeostasis (GO:0001782)2.44866857
146DNA duplex unwinding (GO:0032508)2.44269474
147interferon-gamma secretion (GO:0072643)2.43224307
148gene silencing (GO:0016458)2.42589868
149positive regulation of B cell differentiation (GO:0045579)2.42204173
150regulation of histone methylation (GO:0031060)2.41864497
151snRNA processing (GO:0016180)2.41862809
152spliceosomal tri-snRNP complex assembly (GO:0000244)2.41627098
153DNA strand elongation involved in DNA replication (GO:0006271)2.41093257
154mRNA stabilization (GO:0048255)2.40508302
155RNA stabilization (GO:0043489)2.40508302
156histone H4 acetylation (GO:0043967)2.39484152
157regulation of spindle organization (GO:0090224)2.39352275
158histone lysine demethylation (GO:0070076)2.37694481
159T cell costimulation (GO:0031295)2.37181295
160positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.35402618
161positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.35402618
162positive regulation of mitotic sister chromatid separation (GO:1901970)2.35402618
163DNA demethylation (GO:0080111)2.35328399
1643-UTR-mediated mRNA stabilization (GO:0070935)2.34426318
165mitotic metaphase plate congression (GO:0007080)2.33998371
166DNA strand elongation (GO:0022616)2.33758805
167regulation of histone H3-K27 methylation (GO:0061085)2.29736186
168lymphocyte costimulation (GO:0031294)2.29437831
169negative regulation of histone modification (GO:0031057)2.29184254
170localization within membrane (GO:0051668)2.29147517
171RNA localization (GO:0006403)2.29104505
172histone demethylation (GO:0016577)2.28904360
173negative regulation of chromatin modification (GO:1903309)2.28886076
174positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.28256072
175interferon-gamma production (GO:0032609)2.27683126
176regulation of DNA damage checkpoint (GO:2000001)2.27461654
177regulation of translational termination (GO:0006449)2.27286990

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.06351500
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.37958379
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.95496880
4MYC_22102868_ChIP-Seq_BL_Human3.50511789
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.32402467
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.79697606
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.77233370
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.71897897
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35390428
10SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.30269568
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26825374
12CIITA_25753668_ChIP-Seq_RAJI_Human2.26582459
13VDR_21846776_ChIP-Seq_THP-1_Human2.22939427
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.20284691
15ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.19973735
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.19769983
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.16972125
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15223676
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.12376930
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.03882431
21VDR_24787735_ChIP-Seq_THP-1_Human2.00082391
22MYB_26560356_Chip-Seq_TH2_Human1.97282246
23UTX_26944678_Chip-Seq_JUKART_Human1.96509749
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.87698682
25* MAF_26560356_Chip-Seq_TH1_Human1.87132305
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83179064
27KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.81026769
28TCF7_22412390_ChIP-Seq_EML_Mouse1.78066343
29MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77598332
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.73749534
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73119307
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.72686460
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71109920
34CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.67654762
35VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.66185569
36* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.65177531
37KDM2B_26808549_Chip-Seq_DND41_Human1.64781998
38KDM5A_27292631_Chip-Seq_BREAST_Human1.63864197
39MYB_26560356_Chip-Seq_TH1_Human1.61795200
40SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.61174674
41SPI1_23547873_ChIP-Seq_NB4_Human1.59154815
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.55571274
43RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.54776292
44GATA3_26560356_Chip-Seq_TH2_Human1.54423926
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.52785823
46GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51982047
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.50858116
48SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.50602257
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.49406063
50NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.46994666
51MYC_18555785_ChIP-Seq_MESCs_Mouse1.46954637
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.46875427
53NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46470500
54RUNX_20019798_ChIP-Seq_JUKART_Human1.46026396
55XRN2_22483619_ChIP-Seq_HELA_Human1.45488387
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.44937671
57MAF_26560356_Chip-Seq_TH2_Human1.44148797
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.43698922
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43296109
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.43248351
61VDR_23849224_ChIP-Seq_CD4+_Human1.41288855
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41254266
63GATA1_19941827_ChIP-Seq_MEL_Mouse1.40983119
64KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39143358
65MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38042565
66* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37466699
67HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37348932
68E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35247654
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35195804
70DROSHA_22980978_ChIP-Seq_HELA_Human1.35078238
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35021924
72VDR_24763502_ChIP-Seq_THP-1_Human1.34863043
73CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.34134078
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.33970152
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32973171
76* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.32225313
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.31151583
78GATA1_19941826_ChIP-Seq_K562_Human1.30095605
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.29129414
80POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.26457409
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25931415
82* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.25649448
83ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.24573307
84KLF4_18555785_ChIP-Seq_MESCs_Mouse1.24268644
85TFEB_21752829_ChIP-Seq_HELA_Human1.23059868
86SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22536145
87* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.21817197
88STAT4_19710469_ChIP-ChIP_TH1__Mouse1.21773743
89ZNF274_21170338_ChIP-Seq_K562_Hela1.20542152
90BCL6_27268052_Chip-Seq_Bcells_Human1.19799476
91MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18328933
92CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17798390
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17558948
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17406373
95BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.17084542
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.17000296
97FOXP3_21729870_ChIP-Seq_TREG_Human1.16628364
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16065621
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15050752
100SCL_19346495_ChIP-Seq_HPC-7_Human1.15011510
101GABP_19822575_ChIP-Seq_HepG2_Human1.14667545
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12793272
103SPI1_23127762_ChIP-Seq_K562_Human1.11031253
104PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09437669
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08373320
106BCOR_27268052_Chip-Seq_Bcells_Human1.08286313
107GATA3_27048872_Chip-Seq_THYMUS_Human1.07449501
108THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06952040
109* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06332645
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05965772
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05495500
112PKCTHETA_26484144_Chip-Seq_BREAST_Human1.03276541
113CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02904128
114ETS1_20019798_ChIP-Seq_JURKAT_Human1.02704483
115NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01800428
116NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01434945
117KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00234220
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00176396
119ERG_20887958_ChIP-Seq_HPC-7_Mouse0.99803806
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99631965
121TP63_19390658_ChIP-ChIP_HaCaT_Human0.98547151
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98514776
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98434717
124SALL1_21062744_ChIP-ChIP_HESCs_Human0.97701518
125NCOR1_26117541_ChIP-Seq_K562_Human0.97582080
126SMRT_27268052_Chip-Seq_Bcells_Human0.97278997
127GABP_17652178_ChIP-ChIP_JURKAT_Human0.96636597
128ZFX_18555785_ChIP-Seq_MESCs_Mouse0.95448045
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95415932
130EZH2_22144423_ChIP-Seq_EOC_Human0.95264488
131DCP1A_22483619_ChIP-Seq_HELA_Human0.95109122
132ELK3_25401928_ChIP-Seq_HUVEC_Human0.94048258
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91680638
134PU_27001747_Chip-Seq_BMDM_Mouse0.91226778
135LXR_22292898_ChIP-Seq_THP-1_Human0.90060933
136P300_27268052_Chip-Seq_Bcells_Human0.89905187
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89532835
138ELF1_20517297_ChIP-Seq_JURKAT_Human0.89508019
139KDM2B_26808549_Chip-Seq_JURKAT_Human0.89055630
140CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87752257
141GATA2_21666600_ChIP-Seq_HMVEC_Human0.87543039
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.85822784
143RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85642425
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85436765
145ERA_21632823_ChIP-Seq_H3396_Human0.85011699
146GATA2_19941826_ChIP-Seq_K562_Human0.84770713
147CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84196050
148SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82436800
149PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81780791
150RAC3_21632823_ChIP-Seq_H3396_Human0.80810544
151CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80441295
152PHF8_20622854_ChIP-Seq_HELA_Human0.79859378
153OCT4_19829295_ChIP-Seq_ESCs_Human0.79575975
154RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.77776815
155E2F1_20622854_ChIP-Seq_HELA_Human0.77203288
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76225687
157P68_20966046_ChIP-Seq_HELA_Human0.75726954
158BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.75425016

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to3.81768000
2MP0000569_abnormal_digit_pigmentation3.18456230
3MP0003693_abnormal_embryo_hatching3.13853048
4MP0003111_abnormal_nucleus_morphology3.07054167
5MP0006082_CNS_inflammation2.75466136
6MP0001835_abnormal_antigen_presentation2.72195318
7MP0003763_abnormal_thymus_physiology2.69466646
8* MP0003077_abnormal_cell_cycle2.58199437
9* MP0010094_abnormal_chromosome_stability2.57334774
10MP0003303_peritoneal_inflammation2.43697285
11MP0005076_abnormal_cell_differentiation2.31139692
12MP0001800_abnormal_humoral_immune2.28705243
13MP0005671_abnormal_response_to2.26334780
14MP0010352_gastrointestinal_tract_polyps2.24744874
15MP0002398_abnormal_bone_marrow2.22937774
16MP0008057_abnormal_DNA_replication2.08638756
17MP0003436_decreased_susceptibility_to2.06505949
18MP0004957_abnormal_blastocyst_morpholog2.05615319
19MP0000685_abnormal_immune_system2.02366076
20MP0002452_abnormal_antigen_presenting1.96844509
21MP0002420_abnormal_adaptive_immunity1.95446150
22MP0002254_reproductive_system_inflammat1.95140570
23MP0008058_abnormal_DNA_repair1.94432687
24MP0001819_abnormal_immune_cell1.93821581
25MP0001730_embryonic_growth_arrest1.90169382
26MP0000703_abnormal_thymus_morphology1.84153545
27MP0000716_abnormal_immune_system1.82027828
28MP0001790_abnormal_immune_system1.81426325
29MP0005387_immune_system_phenotype1.81426325
30MP0004381_abnormal_hair_follicle1.80780435
31MP0009764_decreased_sensitivity_to1.76245188
32MP0005000_abnormal_immune_tolerance1.74837700
33MP0009333_abnormal_splenocyte_physiolog1.74778848
34MP0002723_abnormal_immune_serum1.73502112
35MP0000350_abnormal_cell_proliferation1.72848546
36MP0003121_genomic_imprinting1.72832745
37MP0005058_abnormal_lysosome_morphology1.71499471
38MP0000490_abnormal_crypts_of1.71273291
39MP0002722_abnormal_immune_system1.69995887
40MP0002138_abnormal_hepatobiliary_system1.69854514
41MP0008007_abnormal_cellular_replicative1.66833659
42MP0002396_abnormal_hematopoietic_system1.64904424
43MP0000689_abnormal_spleen_morphology1.64114419
44MP0002166_altered_tumor_susceptibility1.59524168
45MP0010307_abnormal_tumor_latency1.57700827
46MP0002429_abnormal_blood_cell1.57403189
47MP0004808_abnormal_hematopoietic_stem1.56477204
48MP0009840_abnormal_foam_cell1.52580406
49MP0005025_abnormal_response_to1.49721519
50MP0002405_respiratory_system_inflammati1.44418732
51MP0002419_abnormal_innate_immunity1.38398678
52MP0005167_abnormal_blood-brain_barrier1.37852523
53MP0002998_abnormal_bone_remodeling1.36874924
54MP0001873_stomach_inflammation1.35321288
55MP0003300_gastrointestinal_ulcer1.35217876
56MP0008469_abnormal_protein_level1.32087178
57* MP0002019_abnormal_tumor_incidence1.31889712
58MP0000465_gastrointestinal_hemorrhage1.31857850
59MP0009278_abnormal_bone_marrow1.29807516
60MP0002006_tumorigenesis1.29391373
61MP0001697_abnormal_embryo_size1.27798227
62MP0010155_abnormal_intestine_physiology1.25784292
63MP0004947_skin_inflammation1.24983075
64MP0004510_myositis1.24137991
65MP0009785_altered_susceptibility_to1.23031226
66MP0005075_abnormal_melanosome_morpholog1.22462141
67MP0005310_abnormal_salivary_gland1.21598743
68MP0002080_prenatal_lethality1.20994250
69MP0000313_abnormal_cell_death1.20523845
70MP0002084_abnormal_developmental_patter1.18329589
71MP0005451_abnormal_body_composition1.12800922
72MP0003172_abnormal_lysosome_physiology1.11989659
73MP0003890_abnormal_embryonic-extraembry1.11940307
74MP0003448_altered_tumor_morphology1.11364636
75MP0005380_embryogenesis_phenotype1.11112632
76MP0001672_abnormal_embryogenesis/_devel1.11112632
77MP0003123_paternal_imprinting1.09651002
78MP0002085_abnormal_embryonic_tissue1.08836267
79MP0001663_abnormal_digestive_system1.08551565
80MP0003646_muscle_fatigue1.08486781
81MP0008877_abnormal_DNA_methylation1.07978690
82MP0002132_abnormal_respiratory_system1.07788843
83MP0008004_abnormal_stomach_pH1.07686612
84MP0005621_abnormal_cell_physiology1.07677569
85MP0002933_joint_inflammation1.07289200
86MP0008961_abnormal_basal_metabolism1.06583974
87MP0002086_abnormal_extraembryonic_tissu1.04986676
88MP0003566_abnormal_cell_adhesion1.04592994
89MP0003984_embryonic_growth_retardation1.04400631
90MP0005397_hematopoietic_system_phenotyp1.03694609
91MP0001545_abnormal_hematopoietic_system1.03694609
92MP0001849_ear_inflammation1.03656632
93MP0003828_pulmonary_edema1.03315929
94MP0002088_abnormal_embryonic_growth/wei1.02083062
95MP0004197_abnormal_fetal_growth/weight/1.01594226
96MP0005384_cellular_phenotype1.00667246
97MP0003866_abnormal_defecation1.00617375
98MP0002277_abnormal_respiratory_mucosa0.98610116
99MP0005174_abnormal_tail_pigmentation0.97392423
100MP0000733_abnormal_muscle_development0.96920413
101MP0008932_abnormal_embryonic_tissue0.95191109
102MP0005464_abnormal_platelet_physiology0.94737832
103MP0000858_altered_metastatic_potential0.94166198
104MP0001929_abnormal_gametogenesis0.93882980
105MP0001915_intracranial_hemorrhage0.92653634
106MP0001845_abnormal_inflammatory_respons0.89886466
107MP0001986_abnormal_taste_sensitivity0.89325005
108MP0002148_abnormal_hypersensitivity_rea0.87324674
109MP0005023_abnormal_wound_healing0.86307241
110MP0002693_abnormal_pancreas_physiology0.85835391
111MP0004883_abnormal_blood_vessel0.85811983
112MP0000371_diluted_coat_color0.83836729
113MP0000604_amyloidosis0.83416972
114MP0003786_premature_aging0.81630657
115MP0000537_abnormal_urethra_morphology0.80046090
116MP0002653_abnormal_ependyma_morphology0.79461122
117MP0001851_eye_inflammation0.78389268
118MP0002210_abnormal_sex_determination0.77872623
119MP0003045_fibrosis0.76907431
120MP0004133_heterotaxia0.76246805
121MP0001501_abnormal_sleep_pattern0.75435254
122MP0003698_abnormal_male_reproductive0.75118249
123MP0008260_abnormal_autophagy0.73342073
124MP0001533_abnormal_skeleton_physiology0.71368405
125MP0004130_abnormal_muscle_cell0.70997340
126MP0003183_abnormal_peptide_metabolism0.70931621
127MP0003221_abnormal_cardiomyocyte_apopto0.69907931
128MP0000015_abnormal_ear_pigmentation0.69905706
129MP0001145_abnormal_male_reproductive0.69545671
130MP0005390_skeleton_phenotype0.69446029
131MP0003656_abnormal_erythrocyte_physiolo0.67469312
132MP0003191_abnormal_cellular_cholesterol0.65516602
133MP0001853_heart_inflammation0.64736686
134MP0000249_abnormal_blood_vessel0.64629063
135MP0009765_abnormal_xenobiotic_induced0.64120750
136MP0009763_increased_sensitivity_to0.60171462
137MP0000343_altered_response_to0.59221167
138MP0005164_abnormal_response_to0.58852177
139MP0000470_abnormal_stomach_morphology0.58668809
140MP0005166_decreased_susceptibility_to0.57977186
141MP0003690_abnormal_glial_cell0.57742165
142MP0003195_calcinosis0.57727979
143MP0005381_digestive/alimentary_phenotyp0.56761522
144MP0009115_abnormal_fat_cell0.55687165
145MP0003075_altered_response_to0.55488598
146MP0003795_abnormal_bone_structure0.54665911
147MP0002332_abnormal_exercise_endurance0.52102093
148MP0003787_abnormal_imprinting0.51493190
149MP0002136_abnormal_kidney_physiology0.49184613
150MP0008872_abnormal_physiological_respon0.48973167

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)5.48418767
2Myositis (HP:0100614)4.73271866
3Optic neuritis (HP:0100653)4.48715406
4Retrobulbar optic neuritis (HP:0100654)4.48715406
5Orchitis (HP:0100796)4.36913253
6Abnormality of macrophages (HP:0004311)4.07988743
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.84237972
8Increased cerebral lipofuscin (HP:0011813)3.82778445
9Increased neuronal autofluorescent lipopigment (HP:0002074)3.74135166
10Recurrent cutaneous fungal infections (HP:0011370)3.60422765
11Chronic mucocutaneous candidiasis (HP:0002728)3.60422765
12Abnormality of the fingertips (HP:0001211)3.51771190
13Abnormality of liposaccharide metabolism (HP:0010968)3.32821925
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.32821925
15Abnormality of glycolipid metabolism (HP:0010969)3.32821925
16Abnormality of the anterior horn cell (HP:0006802)3.32491962
17Degeneration of anterior horn cells (HP:0002398)3.32491962
18Hyperacusis (HP:0010780)3.31167011
19Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.28360221
20Recurrent viral infections (HP:0004429)3.23830981
21Recurrent skin infections (HP:0001581)3.23205423
22Gastrointestinal infarctions (HP:0005244)3.19051164
23Hemoptysis (HP:0002105)3.14565916
24Encephalitis (HP:0002383)3.14265050
25Recurrent abscess formation (HP:0002722)3.12890311
26Keratoconjunctivitis sicca (HP:0001097)3.04493644
27Keratoconjunctivitis (HP:0001096)3.03191441
28Vasculitis (HP:0002633)3.02985262
29T lymphocytopenia (HP:0005403)2.99122379
30Spontaneous hematomas (HP:0007420)2.95540784
31Pustule (HP:0200039)2.95384540
32Pulmonary infiltrates (HP:0002113)2.94819343
33Abnormality of T cell number (HP:0011839)2.87696422
34Recurrent gram-negative bacterial infections (HP:0005420)2.87382117
35Recurrent bronchitis (HP:0002837)2.74845598
36Recurrent bacterial skin infections (HP:0005406)2.71599634
37Hematochezia (HP:0002573)2.71567837
38Eczematoid dermatitis (HP:0000976)2.70314832
39Clumsiness (HP:0002312)2.70146702
40Recurrent fungal infections (HP:0002841)2.69239016
41Vacuolated lymphocytes (HP:0001922)2.68594783
42Increased IgE level (HP:0003212)2.65470894
43Inflammation of the large intestine (HP:0002037)2.58636559
44Atrophy/Degeneration involving motor neurons (HP:0007373)2.58478405
45Cellulitis (HP:0100658)2.54295741
46Colitis (HP:0002583)2.54256736
47Combined immunodeficiency (HP:0005387)2.53813619
48Gingivitis (HP:0000230)2.49469388
49Ependymoma (HP:0002888)2.48953949
50Panhypogammaglobulinemia (HP:0003139)2.48410124
51Cortical dysplasia (HP:0002539)2.42327422
52Prolonged bleeding time (HP:0003010)2.41545213
53Gastrointestinal inflammation (HP:0004386)2.41388113
54Abnormality of the astrocytes (HP:0100707)2.40483103
55Astrocytoma (HP:0009592)2.40483103
56Episodic fever (HP:0001954)2.39772557
57Protruding tongue (HP:0010808)2.38596380
58Severe combined immunodeficiency (HP:0004430)2.37213355
59Heterotopia (HP:0002282)2.35530383
60Dysostosis multiplex (HP:0000943)2.34227137
61Abnormality of T cells (HP:0002843)2.33953904
62Personality changes (HP:0000751)2.32858900
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32566094
64Elevated erythrocyte sedimentation rate (HP:0003565)2.32084576
65Agammaglobulinemia (HP:0004432)2.30339135
66Abnormality of the columella (HP:0009929)2.30060146
67Arterial thrombosis (HP:0004420)2.29387121
68Increased nuchal translucency (HP:0010880)2.24412658
69Abnormality of B cell number (HP:0010975)2.24025981
70B lymphocytopenia (HP:0010976)2.24025981
71Hypochromic anemia (HP:0001931)2.23290110
72Abnormality of cells of the lymphoid lineage (HP:0012140)2.22960633
73Lymphopenia (HP:0001888)2.22292985
74Abnormality of T cell physiology (HP:0011840)2.21885923
75IgM deficiency (HP:0002850)2.21697201
76Urticaria (HP:0001025)2.20395529
77Amyotrophic lateral sclerosis (HP:0007354)2.17769511
78Pulmonary embolism (HP:0002204)2.16640810
79Volvulus (HP:0002580)2.15947343
80Poikiloderma (HP:0001029)2.15281015
81Abnormality of DNA repair (HP:0003254)2.13623321
82Meningitis (HP:0001287)2.13037231
83Cutaneous melanoma (HP:0012056)2.12641773
84Stomach cancer (HP:0012126)2.11561784
85Genetic anticipation (HP:0003743)2.10005200
86Thyroiditis (HP:0100646)2.09736151
87Abnormality of the labia minora (HP:0012880)2.08939020
88Mediastinal lymphadenopathy (HP:0100721)2.06665116
89Anorexia (HP:0002039)2.05905209
90Lymphoma (HP:0002665)2.04241124
91Proximal placement of thumb (HP:0009623)2.04114784
92Chest pain (HP:0100749)2.04012919
93Deviation of the thumb (HP:0009603)2.02603589
94Birth length less than 3rd percentile (HP:0003561)2.01263846
95Disinhibition (HP:0000734)2.00530114
96Eosinophilia (HP:0001880)2.00254844
97Abnormality of the carotid arteries (HP:0005344)2.00120285
98Increased IgM level (HP:0003496)1.99918682
99Spinal muscular atrophy (HP:0007269)1.99778680
100Overriding aorta (HP:0002623)1.99714266
101Neoplasm of the adrenal cortex (HP:0100641)1.99358182
102Abnormality of the pleura (HP:0002103)1.99252988
103Abnormality of the motor neurons (HP:0002450)1.98293447
104Abnormal neuron morphology (HP:0012757)1.98293447
105Ectopic kidney (HP:0000086)1.96719533
106Papilloma (HP:0012740)1.96658916
107Verrucae (HP:0200043)1.96658916
108Leukocytosis (HP:0001974)1.95642519
109Recurrent sinusitis (HP:0011108)1.95515268
110Increased serum ferritin (HP:0003281)1.94655520
111Prominent nose (HP:0000448)1.93491481
112Myelodysplasia (HP:0002863)1.93448926
113Insomnia (HP:0100785)1.91918646
114Abnormality of polysaccharide metabolism (HP:0011012)1.90596466
115Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90596466
116Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90596466
117Amaurosis fugax (HP:0100576)1.90224050
118Epistaxis (HP:0000421)1.90095627
119Basal cell carcinoma (HP:0002671)1.89893616
120Congenital stationary night blindness (HP:0007642)1.88915185
121Autoimmune hemolytic anemia (HP:0001890)1.88484315
122Aplasia/Hypoplasia of the uvula (HP:0010293)1.87586640
123Neoplasm of the oral cavity (HP:0100649)1.86991037
124Medulloblastoma (HP:0002885)1.86345847
125Abnormality of iron homeostasis (HP:0011031)1.85629071
126Cutis marmorata (HP:0000965)1.85533917
127Loss of speech (HP:0002371)1.85102864
128Nasal polyposis (HP:0100582)1.84779958
129Abnormality of transition element cation homeostasis (HP:0011030)1.84607501
130Keratitis (HP:0000491)1.84430873
131Gangrene (HP:0100758)1.84371725
132IgG deficiency (HP:0004315)1.83967584
133Cheilitis (HP:0100825)1.83900219
134Restrictive lung disease (HP:0002091)1.83516985
135Glioma (HP:0009733)1.83010080
136Abnormality of the endocardium (HP:0004306)1.82902826
137Chronic diarrhea (HP:0002028)1.82428692
138Selective tooth agenesis (HP:0001592)1.82187119
139Abnormality of chromosome stability (HP:0003220)1.80921973
140Polyneuropathy (HP:0001271)1.80881459
141Elfin facies (HP:0004428)1.80407105
142Macroglossia (HP:0000158)1.79242065
143Periodontitis (HP:0000704)1.79203441
144Abnormality of eosinophils (HP:0001879)1.78767369
145Agnosia (HP:0010524)1.78144351
146Neoplasm of the tracheobronchial system (HP:0100552)1.76590271
147Entropion (HP:0000621)1.75922045
148Thoracic kyphosis (HP:0002942)1.75676367
149Obstructive lung disease (HP:0006536)1.74818357
150Chronic obstructive pulmonary disease (HP:0006510)1.74818357
151Bronchitis (HP:0012387)1.74632545
152Alveolar cell carcinoma (HP:0006519)1.74198258
153Trigonocephaly (HP:0000243)1.73927213
154Abnormality of chromosome segregation (HP:0002916)1.73632963
155Long eyelashes (HP:0000527)1.73333996
156Hypoplasia of the capital femoral epiphysis (HP:0003090)1.72960290
157Cellular immunodeficiency (HP:0005374)1.72738243
158Renovascular hypertension (HP:0100817)1.72498103
159Leukopenia (HP:0001882)1.71901158
160Supranuclear gaze palsy (HP:0000605)1.71659477
161Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.71410838
162Cafe-au-lait spot (HP:0000957)1.71408588
163Chronic otitis media (HP:0000389)1.70144248
164Autoimmune thrombocytopenia (HP:0001973)1.70107057
165Granulocytopenia (HP:0001913)1.70042056
166Recurrent otitis media (HP:0000403)1.69855268
167Pointed chin (HP:0000307)1.69113600
168Bone marrow hypocellularity (HP:0005528)1.68207775
169Optic nerve coloboma (HP:0000588)1.68153391
170Osteomyelitis (HP:0002754)1.67966146
171Long palpebral fissure (HP:0000637)1.67961487
172Leiomyosarcoma (HP:0100243)1.67712099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K104.22426729
2MAP4K13.49817210
3TESK23.12044124
4EEF2K3.07572293
5FRK2.68199982
6RIPK42.60816184
7NEK22.48268219
8CDK122.46488668
9STK102.25823675
10KSR12.18928860
11CDC72.04982719
12SIK32.00431481
13MARK31.94887621
14TESK11.93898846
15MAP2K31.88463557
16FES1.86237180
17TNK21.80863005
18ICK1.80558272
19BRD41.72376696
20MARK11.72159336
21EPHB11.61361309
22ADRBK21.58193715
23PASK1.58039402
24PINK11.53000814
25IKBKB1.48583102
26TXK1.47915664
27ITK1.47699558
28ATR1.40734196
29SCYL21.38470852
30TYK21.36757430
31SIK21.36488664
32RPS6KB21.35012494
33PAK61.34986651
34TBK11.34737945
35BTK1.34439385
36DYRK31.31692086
37MAP3K111.28508464
38EPHA31.28041631
39FGR1.27399816
40TRIB31.26754552
41IRAK41.26612936
42GRK61.25904600
43NLK1.23780223
44MATK1.23696634
45ZAP701.22910171
46CDC42BPA1.22448387
47DYRK21.21658620
48MAP3K131.21520125
49BUB11.21232887
50DYRK1B1.13802521
51KIT1.10698334
52TEC1.07733825
53ERN11.06360862
54PKN21.04574453
55MAP3K81.02909829
56MARK21.02107970
57PIM11.01815824
58TLK11.01460699
59JAK31.01290125
60SYK1.00714247
61MAP3K141.00251400
62STK40.98253761
63BCR0.98094531
64MAP3K10.97326434
65MAP3K30.97062046
66RPS6KA60.95172113
67CDK40.93126249
68TTK0.93018871
69CLK10.92281267
70PRKCQ0.92230735
71PRPF4B0.91906459
72CAMKK20.91827783
73SGK20.90203907
74CHEK20.89529340
75BLK0.88724029
76CHEK10.88386594
77PDK10.87339819
78EIF2AK10.87124938
79ALK0.87025759
80GRK70.85969284
81DAPK20.84805393
82BMPR1B0.83357993
83ACVR1B0.81136427
84MAP3K70.81090003
85CSF1R0.81035607
86HCK0.80135336
87RPS6KL10.79450227
88RPS6KC10.79450227
89PRKD20.79427949
90HIPK20.79196599
91RPS6KA20.76588041
92PTK2B0.76558962
93CSNK1A1L0.76515324
94CAMKK10.76470523
95UHMK10.76426345
96LIMK10.76292482
97CSNK1G30.73996707
98KSR20.73630171
99PAK40.73538715
100IRAK30.73285018
101LRRK20.72606130
102MAP2K20.71854615
103CHUK0.71588286
104SGK2230.71230608
105SGK4940.71230608
106IRAK10.70181368
107CDK60.69196638
108CDK20.68658540
109PLK10.68285097
110MAPK120.67399992
111TAOK10.66468148
112PDPK10.65293076
113RAF10.64372267
114CAMK1D0.63979170
115PAK30.62139602
116JAK10.62082044
117SGK30.62028461
118CSNK1G20.61923594
119LCK0.60677563
120CSK0.60312444
121MAP3K90.58761352
122IRAK20.55389684
123TAOK30.55383379
124CSNK1D0.55070727
125CDK180.54483538
126TGFBR20.53499220
127CAMK40.53281132
128BRSK10.52564343
129MELK0.50957090
130RPS6KA40.50603127
131ATM0.50468397
132FGFR40.49458241
133DYRK1A0.48627392
134PTK60.47453853
135TYRO30.47404366
136TGFBR10.47288125
137WEE10.46596813
138PIK3CG0.46368265
139MAPK70.45729841
140STK110.44740666
141JAK20.44610435
142CDK70.44435182
143CDK10.44334405
144PDGFRB0.43946691
145CSNK1G10.43865171
146CDK150.43787562
147* MTOR0.43315549
148IKBKE0.43197356
149MAPK110.42993399
150FGFR30.42507039
151MAPK90.42233611
152AURKB0.42115831
153PRKCZ0.40820188
154MAP3K60.40768426
155PAK10.40739465
156ERBB30.40116897
157MAP2K60.38980632
158GRK10.38760944
159ADRBK10.38503999
160PRKCH0.38501676
161TRPM70.37786553
162LYN0.37613972
163TAOK20.32532512
164RPS6KA50.31825254

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.63928255
2Autoimmune thyroid disease_Homo sapiens_hsa053202.31563704
3Staphylococcus aureus infection_Homo sapiens_hsa051502.15734579
4Asthma_Homo sapiens_hsa053102.12929990
5Base excision repair_Homo sapiens_hsa034102.05649158
6B cell receptor signaling pathway_Homo sapiens_hsa046622.01353865
7Cell cycle_Homo sapiens_hsa041101.98007582
8DNA replication_Homo sapiens_hsa030301.94647058
9Spliceosome_Homo sapiens_hsa030401.94041991
10mRNA surveillance pathway_Homo sapiens_hsa030151.90748122
11T cell receptor signaling pathway_Homo sapiens_hsa046601.89686387
12Type I diabetes mellitus_Homo sapiens_hsa049401.88622904
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.84100128
14RNA transport_Homo sapiens_hsa030131.80474424
15Antigen processing and presentation_Homo sapiens_hsa046121.78924535
16Mismatch repair_Homo sapiens_hsa034301.72301399
17Viral myocarditis_Homo sapiens_hsa054161.68895109
18Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64956837
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64732272
20Other glycan degradation_Homo sapiens_hsa005111.63501473
21Colorectal cancer_Homo sapiens_hsa052101.62303788
22Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.57491251
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.55880715
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.54803213
25Herpes simplex infection_Homo sapiens_hsa051681.48775663
26Measles_Homo sapiens_hsa051621.43910505
27Chronic myeloid leukemia_Homo sapiens_hsa052201.43830936
28Shigellosis_Homo sapiens_hsa051311.43262711
29Leishmaniasis_Homo sapiens_hsa051401.42705697
30Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.40660341
31Rheumatoid arthritis_Homo sapiens_hsa053231.38971888
32p53 signaling pathway_Homo sapiens_hsa041151.34430169
33Malaria_Homo sapiens_hsa051441.33015376
34Epstein-Barr virus infection_Homo sapiens_hsa051691.31244343
35Pancreatic cancer_Homo sapiens_hsa052121.29822463
36Non-homologous end-joining_Homo sapiens_hsa034501.29416596
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.28975106
38Nucleotide excision repair_Homo sapiens_hsa034201.28676279
39Endometrial cancer_Homo sapiens_hsa052131.27891518
40Apoptosis_Homo sapiens_hsa042101.26319581
41Viral carcinogenesis_Homo sapiens_hsa052031.25337385
42Osteoclast differentiation_Homo sapiens_hsa043801.23379513
43Toxoplasmosis_Homo sapiens_hsa051451.22619433
44Lysosome_Homo sapiens_hsa041421.22458780
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.21576756
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19767488
47Fanconi anemia pathway_Homo sapiens_hsa034601.17095233
48Acute myeloid leukemia_Homo sapiens_hsa052211.17000665
49HTLV-I infection_Homo sapiens_hsa051661.16911421
50Non-small cell lung cancer_Homo sapiens_hsa052231.14604966
51MicroRNAs in cancer_Homo sapiens_hsa052061.12485080
52Hepatitis B_Homo sapiens_hsa051611.11534438
53Influenza A_Homo sapiens_hsa051641.11226214
54Notch signaling pathway_Homo sapiens_hsa043301.09194081
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.08774822
56Leukocyte transendothelial migration_Homo sapiens_hsa046701.07167468
57Phagosome_Homo sapiens_hsa041451.05691197
58Small cell lung cancer_Homo sapiens_hsa052221.05125921
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05002414
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.04020837
61Basal transcription factors_Homo sapiens_hsa030221.02679386
62VEGF signaling pathway_Homo sapiens_hsa043701.01464971
63Graft-versus-host disease_Homo sapiens_hsa053321.00055277
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.99956586
65mTOR signaling pathway_Homo sapiens_hsa041500.99692891
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98874231
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98581279
68Oocyte meiosis_Homo sapiens_hsa041140.97635596
69Pertussis_Homo sapiens_hsa051330.96326469
70Chemokine signaling pathway_Homo sapiens_hsa040620.95851828
71Legionellosis_Homo sapiens_hsa051340.94701334
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94636709
73Renal cell carcinoma_Homo sapiens_hsa052110.94207356
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91792733
75RNA degradation_Homo sapiens_hsa030180.91579827
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.91390137
77Homologous recombination_Homo sapiens_hsa034400.90230975
78Hematopoietic cell lineage_Homo sapiens_hsa046400.90168896
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88458468
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84182750
81African trypanosomiasis_Homo sapiens_hsa051430.83206157
82Tuberculosis_Homo sapiens_hsa051520.78624736
83Endocytosis_Homo sapiens_hsa041440.78407403
84Salmonella infection_Homo sapiens_hsa051320.76958763
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.76709530
86Allograft rejection_Homo sapiens_hsa053300.76454264
87FoxO signaling pathway_Homo sapiens_hsa040680.75961797
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.75459921
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75322431
90Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75295190
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70689420
92Systemic lupus erythematosus_Homo sapiens_hsa053220.64484648
93Type II diabetes mellitus_Homo sapiens_hsa049300.64178911
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63614340
95Prolactin signaling pathway_Homo sapiens_hsa049170.63363374
96TNF signaling pathway_Homo sapiens_hsa046680.62738191
97Phototransduction_Homo sapiens_hsa047440.61736741
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60083779
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59892924
100Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59178176
101Regulation of autophagy_Homo sapiens_hsa041400.59162841
102Adherens junction_Homo sapiens_hsa045200.59112827
103Inositol phosphate metabolism_Homo sapiens_hsa005620.58529455
104Hepatitis C_Homo sapiens_hsa051600.58523623
105Pathways in cancer_Homo sapiens_hsa052000.58505444
106Hippo signaling pathway_Homo sapiens_hsa043900.58058529
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57751719
108Ether lipid metabolism_Homo sapiens_hsa005650.57277046
109Proteoglycans in cancer_Homo sapiens_hsa052050.57042752
110Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56949007
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.56551686
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56270643
113GnRH signaling pathway_Homo sapiens_hsa049120.55145819
114Dorso-ventral axis formation_Homo sapiens_hsa043200.53772094
115Prostate cancer_Homo sapiens_hsa052150.53288060
116ABC transporters_Homo sapiens_hsa020100.52921167
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52853843
118Lysine degradation_Homo sapiens_hsa003100.52746311
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.51546424
120Platelet activation_Homo sapiens_hsa046110.51495621
121One carbon pool by folate_Homo sapiens_hsa006700.51381689
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.50651650
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49750241
124ErbB signaling pathway_Homo sapiens_hsa040120.49464639
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48843328
126Alcoholism_Homo sapiens_hsa050340.48742648
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48553143
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.48186675
129Insulin resistance_Homo sapiens_hsa049310.47468850
130Choline metabolism in cancer_Homo sapiens_hsa052310.46616744
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46247357
132Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.46147084
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45781383
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45582096
135Linoleic acid metabolism_Homo sapiens_hsa005910.45153857
136Basal cell carcinoma_Homo sapiens_hsa052170.44673534
137MAPK signaling pathway_Homo sapiens_hsa040100.43160512
138Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42099877
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.41313132
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40935953
141Oxytocin signaling pathway_Homo sapiens_hsa049210.40449629
142Ras signaling pathway_Homo sapiens_hsa040140.37093645
143Estrogen signaling pathway_Homo sapiens_hsa049150.36799765

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