CHERP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.94843881
2pre-miRNA processing (GO:0031054)4.56566797
3heterochromatin organization (GO:0070828)4.54323346
4protein localization to kinetochore (GO:0034501)4.45864673
5regulation of mammary gland epithelial cell proliferation (GO:0033599)4.37458350
6nuclear pore organization (GO:0006999)4.32033773
7mitotic nuclear envelope disassembly (GO:0007077)4.31077473
8nuclear pore complex assembly (GO:0051292)4.17581109
9negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.14115368
10membrane disassembly (GO:0030397)4.03973254
11nuclear envelope disassembly (GO:0051081)4.03973254
12negative regulation of erythrocyte differentiation (GO:0045647)3.96125176
13proline biosynthetic process (GO:0006561)3.93897462
14COPI coating of Golgi vesicle (GO:0048205)3.91731293
15Golgi transport vesicle coating (GO:0048200)3.91731293
16regulation of translational fidelity (GO:0006450)3.91344479
17folic acid-containing compound biosynthetic process (GO:0009396)3.87523581
18apoptotic process involved in morphogenesis (GO:0060561)3.82171116
19formation of translation preinitiation complex (GO:0001731)3.77562123
20protein localization to chromosome, centromeric region (GO:0071459)3.76753728
21regulation of chromatin binding (GO:0035561)3.74406149
22IMP biosynthetic process (GO:0006188)3.70433178
23DNA strand elongation involved in DNA replication (GO:0006271)3.63746606
24mitotic sister chromatid segregation (GO:0000070)3.62911828
25negative regulation of RNA splicing (GO:0033119)3.61386779
26DNA replication initiation (GO:0006270)3.60861687
27planar cell polarity pathway involved in neural tube closure (GO:0090179)3.59789850
28DNA duplex unwinding (GO:0032508)3.56041764
29regulation of translational termination (GO:0006449)3.54246106
30negative regulation of histone methylation (GO:0031061)3.53899465
31DNA geometric change (GO:0032392)3.53326026
32negative regulation of mRNA processing (GO:0050686)3.50740198
33adherens junction assembly (GO:0034333)3.49623499
34sister chromatid segregation (GO:0000819)3.43550672
35DNA strand elongation (GO:0022616)3.42981388
36regulation of posttranscriptional gene silencing (GO:0060147)3.42057554
37regulation of gene silencing by miRNA (GO:0060964)3.42057554
38regulation of gene silencing by RNA (GO:0060966)3.42057554
39histone H4-K12 acetylation (GO:0043983)3.41904351
40activation of Rac GTPase activity (GO:0032863)3.41449832
41mitotic chromosome condensation (GO:0007076)3.41278864
42DNA replication-dependent nucleosome organization (GO:0034723)3.37387948
43DNA replication-dependent nucleosome assembly (GO:0006335)3.37387948
44regulation of nucleobase-containing compound transport (GO:0032239)3.35956425
45cellular protein complex localization (GO:0034629)3.34932393
46dosage compensation (GO:0007549)3.33785085
47negative regulation of mRNA metabolic process (GO:1903312)3.33083783
48intracellular estrogen receptor signaling pathway (GO:0030520)3.32700463
49protein complex localization (GO:0031503)3.30335906
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.29218538
51regulation of early endosome to late endosome transport (GO:2000641)3.29047495
52nuclear envelope organization (GO:0006998)3.28712973
53peptidyl-arginine omega-N-methylation (GO:0035247)3.27083558
54positive regulation of chromosome segregation (GO:0051984)3.26222908
55DNA replication checkpoint (GO:0000076)3.25436866
56negative regulation of cell size (GO:0045792)3.23088585
57cell-substrate adherens junction assembly (GO:0007045)3.22582064
58focal adhesion assembly (GO:0048041)3.22582064
59chromatin assembly (GO:0031497)3.21827404
60maternal placenta development (GO:0001893)3.21029089
61regulation of spindle organization (GO:0090224)3.20507685
62mRNA stabilization (GO:0048255)3.15034489
63RNA stabilization (GO:0043489)3.15034489
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.14513396
65IMP metabolic process (GO:0046040)3.14019161
66regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.13725473
67retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.13692549
68nucleobase biosynthetic process (GO:0046112)3.13569717
69protein retention in ER lumen (GO:0006621)3.12834833
70mitotic G1 DNA damage checkpoint (GO:0031571)3.11964792
71spliceosomal tri-snRNP complex assembly (GO:0000244)3.10774944
72glucocorticoid receptor signaling pathway (GO:0042921)3.08957370
73regulation of RNA export from nucleus (GO:0046831)3.07837405
74pore complex assembly (GO:0046931)3.07433664
75mitotic metaphase plate congression (GO:0007080)3.07255896
76regulation of histone H3-K27 methylation (GO:0061085)3.06626706
77regulation of histone H3-K9 methylation (GO:0051570)3.06270468
78regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.05796253
79telomere maintenance via semi-conservative replication (GO:0032201)3.04665431
80mitotic sister chromatid cohesion (GO:0007064)3.03960612
81regulation of sister chromatid cohesion (GO:0007063)2.96798902
82protein-DNA complex disassembly (GO:0032986)2.96218058
83nucleosome disassembly (GO:0006337)2.96218058
843-UTR-mediated mRNA stabilization (GO:0070935)2.95399890
85positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.93048316
86regulation of mitotic spindle organization (GO:0060236)2.92785717
87protein localization to chromosome (GO:0034502)2.92762099
88corticosteroid receptor signaling pathway (GO:0031958)2.92641437
89RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.89629890
90mRNA splicing, via spliceosome (GO:0000398)2.89629890
91peptidyl-arginine methylation (GO:0018216)2.88738864
92peptidyl-arginine N-methylation (GO:0035246)2.88738864
93snRNA metabolic process (GO:0016073)2.88694368
94pentose-phosphate shunt (GO:0006098)2.87965989
95RNA splicing, via transesterification reactions (GO:0000375)2.87958030
96DNA conformation change (GO:0071103)2.87792882
97histone H2A monoubiquitination (GO:0035518)2.84417753
98mRNA transport (GO:0051028)2.84302987
99positive regulation of SMAD protein import into nucleus (GO:0060391)2.83409568
100trophectodermal cell differentiation (GO:0001829)2.83273452
101histone arginine methylation (GO:0034969)2.81296219
102translesion synthesis (GO:0019985)2.80850703
103protein export from nucleus (GO:0006611)2.80840256
104positive regulation of DNA-dependent DNA replication (GO:2000105)2.80601235
105positive regulation of mitotic sister chromatid separation (GO:1901970)2.80413581
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80413581
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80413581
108regulation of glucose import in response to insulin stimulus (GO:2001273)2.80212579
109snRNA processing (GO:0016180)2.80023147
110gene silencing (GO:0016458)2.79648042
111modulation by virus of host process (GO:0019054)2.79592201
112alternative mRNA splicing, via spliceosome (GO:0000380)2.78790780
113cellular response to epidermal growth factor stimulus (GO:0071364)2.77208135
114chromatin assembly or disassembly (GO:0006333)2.76810296
115ribosome biogenesis (GO:0042254)2.76715526
116positive regulation of gene expression, epigenetic (GO:0045815)2.76287338
117gene silencing by RNA (GO:0031047)2.75705885
118DNA topological change (GO:0006265)2.75024114
119regulation of DNA damage checkpoint (GO:2000001)2.74820197
120stress granule assembly (GO:0034063)2.74470728
121paraxial mesoderm development (GO:0048339)2.74291141
122activation of MAPKKK activity (GO:0000185)2.74056052
123chromatin silencing (GO:0006342)2.73233079
124protein localization to endosome (GO:0036010)2.69882827
125ribosome assembly (GO:0042255)2.67991792
126attachment of spindle microtubules to kinetochore (GO:0008608)2.67721578
127mitotic G1/S transition checkpoint (GO:0044819)2.67490649
128NLS-bearing protein import into nucleus (GO:0006607)2.66498211
129metaphase plate congression (GO:0051310)2.66496310
130chromosome condensation (GO:0030261)2.65227529
131telomere maintenance via recombination (GO:0000722)2.64955158
132regulation of chromosome segregation (GO:0051983)2.63983593
133histone H4-K5 acetylation (GO:0043981)2.63219319
134histone H4-K8 acetylation (GO:0043982)2.63219319
135base-excision repair (GO:0006284)2.62437000
136regulation of mRNA stability (GO:0043488)2.62421428
137mitotic recombination (GO:0006312)2.61638442
138histone H3-K36 demethylation (GO:0070544)2.60155585
139negative regulation of viral release from host cell (GO:1902187)2.59779828
140rRNA transcription (GO:0009303)2.59569509
141modulation by symbiont of host cellular process (GO:0044068)2.59272132
142proline metabolic process (GO:0006560)2.57864673
143regulation of RNA stability (GO:0043487)2.55203916
144cell-cell junction maintenance (GO:0045217)2.54973583
145convergent extension (GO:0060026)2.54836996
146positive regulation of nuclease activity (GO:0032075)2.54519337
147glucose 6-phosphate metabolic process (GO:0051156)2.53925831
148activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.53644774
149modulation by virus of host morphology or physiology (GO:0019048)2.53448159
150glucose catabolic process (GO:0006007)2.52365719
151cytoskeletal anchoring at plasma membrane (GO:0007016)2.51098270
152RNA localization (GO:0006403)2.49893829
153nuclear envelope reassembly (GO:0031468)2.48097015
154mitotic nuclear envelope reassembly (GO:0007084)2.48097015
155NADPH regeneration (GO:0006740)2.45807437
156cellular hyperosmotic response (GO:0071474)2.43084231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.63473898
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.34237001
3MYC_22102868_ChIP-Seq_BL_Human3.39507981
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.33405403
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.17349235
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.07981801
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.83511929
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.64482254
9* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49414878
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.23319066
11VDR_21846776_ChIP-Seq_THP-1_Human2.16404876
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07732305
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.98169229
14CIITA_25753668_ChIP-Seq_RAJI_Human1.95073038
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.94257495
16TP63_17297297_ChIP-ChIP_HaCaT_Human1.94028102
17XRN2_22483619_ChIP-Seq_HELA_Human1.93423466
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82602926
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80966065
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.79873323
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78130140
22AR_21909140_ChIP-Seq_LNCAP_Human1.71705231
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71701884
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69046703
25TCF7_22412390_ChIP-Seq_EML_Mouse1.63808103
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.63513034
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62758420
28KDM2B_26808549_Chip-Seq_K562_Human1.58843566
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.57797681
30* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.57312375
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.55489552
32* ETS1_20019798_ChIP-Seq_JURKAT_Human1.55321624
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.54418767
34CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54122343
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.53935222
36* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.53247774
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52428402
38KDM5A_27292631_Chip-Seq_BREAST_Human1.51693945
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51446727
40POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.49899881
41KDM2B_26808549_Chip-Seq_DND41_Human1.49509647
42ELK3_25401928_ChIP-Seq_HUVEC_Human1.49228925
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48971238
44DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.46221070
45RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44108001
46PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.44077592
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43009727
48TET1_21451524_ChIP-Seq_MESCs_Mouse1.42612248
49KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42445617
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40358880
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.38153071
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36996556
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.36686641
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.36067803
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35801158
56* GABP_19822575_ChIP-Seq_HepG2_Human1.34869809
57CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34265857
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34059533
59UTX_26944678_Chip-Seq_JUKART_Human1.33856521
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33005553
61SA1_27219007_Chip-Seq_ERYTHROID_Human1.29955977
62MAF_26560356_Chip-Seq_TH1_Human1.29542356
63KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29337190
64CREB1_26743006_Chip-Seq_LNCaP_Human1.29055794
65UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.28852003
66HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.28176393
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28090172
68SRY_22984422_ChIP-ChIP_TESTIS_Rat1.27805456
69P300_27058665_Chip-Seq_ZR-75-30cells_Human1.26903759
70THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25595773
71WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24900983
72TFEB_21752829_ChIP-Seq_HELA_Human1.24245705
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23165588
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23165588
75KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23165588
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22379229
77SMC4_20622854_ChIP-Seq_HELA_Human1.21214944
78TTF2_22483619_ChIP-Seq_HELA_Human1.20904320
79CLOCK_20551151_ChIP-Seq_293T_Human1.20518884
80FOXP3_21729870_ChIP-Seq_TREG_Human1.20312157
81CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.19629755
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.19409878
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18280597
84JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.17618363
85* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16312164
86KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16257845
87VDR_23849224_ChIP-Seq_CD4+_Human1.14561199
88YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14173276
89NANOG_21062744_ChIP-ChIP_HESCs_Human1.14037506
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13578180
91* DCP1A_22483619_ChIP-Seq_HELA_Human1.12294159
92* ELF1_20517297_ChIP-Seq_JURKAT_Human1.12256441
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11863818
94NCOR1_26117541_ChIP-Seq_K562_Human1.09499560
95ATF3_27146783_Chip-Seq_COLON_Human1.09330590
96ZNF263_19887448_ChIP-Seq_K562_Human1.08898850
97RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07518801
98SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07390814
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06903875
100STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06848247
101SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06529285
102TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05918435
103LXR_22292898_ChIP-Seq_THP-1_Human1.05566697
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04765831
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04489597
106ESR1_15608294_ChIP-ChIP_MCF-7_Human1.03532683
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03427236
108TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03227108
109E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02987867
110TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01720971
111RUNX1_22412390_ChIP-Seq_EML_Mouse1.01476358
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00735917
113MAF_26560356_Chip-Seq_TH2_Human1.00274039
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00212959
115RACK7_27058665_Chip-Seq_MCF-7_Human1.00048993
116* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99993770
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99514123
118SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98762526
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98489289
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98250737
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96817800
122KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96098315
123HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96059472
124MYB_26560356_Chip-Seq_TH1_Human0.95992154
125CHD1_26751641_Chip-Seq_LNCaP_Human0.95971789
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95494739
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95208690
128RARA_24833708_ChIP-Seq_LIVER_Mouse0.94793857
129YY1_21170310_ChIP-Seq_MESCs_Mouse0.94642303
130SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91612757
131NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.91552321
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91383130
133VDR_24763502_ChIP-Seq_THP-1_Human0.91122841
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.90571023
135P68_20966046_ChIP-Seq_HELA_Human0.90364796
136STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88974556
137DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88891846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology3.65562150
2MP0003693_abnormal_embryo_hatching3.50440244
3MP0010352_gastrointestinal_tract_polyps3.44708876
4MP0004957_abnormal_blastocyst_morpholog3.39011216
5MP0010094_abnormal_chromosome_stability3.31605464
6MP0003077_abnormal_cell_cycle3.13197347
7MP0008057_abnormal_DNA_replication3.08664558
8MP0005451_abnormal_body_composition3.03971061
9MP0005076_abnormal_cell_differentiation2.79871823
10MP0003705_abnormal_hypodermis_morpholog2.73839294
11MP0000678_abnormal_parathyroid_gland2.72668988
12MP0002249_abnormal_larynx_morphology2.66210548
13MP0001730_embryonic_growth_arrest2.58043333
14MP0004858_abnormal_nervous_system2.38453583
15MP0002396_abnormal_hematopoietic_system2.27014348
16MP0000350_abnormal_cell_proliferation2.25480750
17MP0009278_abnormal_bone_marrow2.25387876
18MP0010307_abnormal_tumor_latency2.05068130
19MP0008260_abnormal_autophagy2.03338968
20MP0008007_abnormal_cellular_replicative2.02628457
21MP0003123_paternal_imprinting2.01529853
22MP0005380_embryogenesis_phenotype2.00881204
23MP0001672_abnormal_embryogenesis/_devel2.00881204
24MP0002653_abnormal_ependyma_morphology2.00649255
25MP0003984_embryonic_growth_retardation1.92455477
26MP0004197_abnormal_fetal_growth/weight/1.91696619
27MP0008058_abnormal_DNA_repair1.89416532
28MP0002088_abnormal_embryonic_growth/wei1.88756022
29MP0001697_abnormal_embryo_size1.88736547
30MP0002084_abnormal_developmental_patter1.85905681
31MP0004808_abnormal_hematopoietic_stem1.85362563
32MP0010030_abnormal_orbit_morphology1.79903697
33MP0002085_abnormal_embryonic_tissue1.79444517
34MP0002086_abnormal_extraembryonic_tissu1.76488854
35MP0001346_abnormal_lacrimal_gland1.73708389
36MP0002080_prenatal_lethality1.71742267
37MP0008877_abnormal_DNA_methylation1.69203296
38MP0008932_abnormal_embryonic_tissue1.68385687
39MP0000566_synostosis1.66532392
40MP0005397_hematopoietic_system_phenotyp1.66448596
41MP0001545_abnormal_hematopoietic_system1.66448596
42MP0001849_ear_inflammation1.66127962
43MP0005666_abnormal_adipose_tissue1.59534051
44MP0010234_abnormal_vibrissa_follicle1.59101139
45MP0001348_abnormal_lacrimal_gland1.57544499
46MP0005058_abnormal_lysosome_morphology1.55417914
47MP0002796_impaired_skin_barrier1.54042653
48MP0003453_abnormal_keratinocyte_physiol1.50453412
49MP0003566_abnormal_cell_adhesion1.49191086
50MP0000490_abnormal_crypts_of1.49182489
51MP0005501_abnormal_skin_physiology1.45204080
52MP0005409_darkened_coat_color1.44290360
53MP0003119_abnormal_digestive_system1.39554241
54MP0005375_adipose_tissue_phenotype1.38184013
55MP0000703_abnormal_thymus_morphology1.37182916
56MP0000003_abnormal_adipose_tissue1.35742182
57MP0000313_abnormal_cell_death1.33529204
58MP0003567_abnormal_fetal_cardiomyocyte1.31461051
59MP0005023_abnormal_wound_healing1.31213316
60MP0002019_abnormal_tumor_incidence1.30841286
61MP0003890_abnormal_embryonic-extraembry1.29186753
62MP0003121_genomic_imprinting1.28249604
63MP0009053_abnormal_anal_canal1.21524032
64MP0004233_abnormal_muscle_weight1.21419008
65MP0009672_abnormal_birth_weight1.20353709
66MP0000733_abnormal_muscle_development1.20099297
67MP0008961_abnormal_basal_metabolism1.18067226
68MP0003763_abnormal_thymus_physiology1.17979107
69MP0002398_abnormal_bone_marrow1.17653645
70MP0001915_intracranial_hemorrhage1.16754327
71MP0009333_abnormal_splenocyte_physiolog1.16548011
72MP0003786_premature_aging1.14960863
73MP0000537_abnormal_urethra_morphology1.10219664
74MP0002722_abnormal_immune_system1.09507614
75MP0001293_anophthalmia1.06997021
76MP0004264_abnormal_extraembryonic_tissu1.06347170
77MP0003300_gastrointestinal_ulcer1.05062303
78MP0002925_abnormal_cardiovascular_devel1.03582594
79MP0000428_abnormal_craniofacial_morphol1.01293384
80MP0003942_abnormal_urinary_system1.01166759
81MP0009703_decreased_birth_body0.98908314
82MP0000689_abnormal_spleen_morphology0.98631903
83MP0003303_peritoneal_inflammation0.96881712
84MP0003283_abnormal_digestive_organ0.96192207
85MP0005621_abnormal_cell_physiology0.94953415
86MP0003172_abnormal_lysosome_physiology0.94608293
87MP0003115_abnormal_respiratory_system0.93299077
88MP0008770_decreased_survivor_rate0.91416669
89MP0009840_abnormal_foam_cell0.90474109
90MP0000685_abnormal_immune_system0.89516896
91MP0000747_muscle_weakness0.87529850
92MP0005384_cellular_phenotype0.87492437
93MP0000759_abnormal_skeletal_muscle0.87358065
94MP0000751_myopathy0.85864766
95MP0000266_abnormal_heart_morphology0.85064772
96MP0010630_abnormal_cardiac_muscle0.83237710
97MP0002210_abnormal_sex_determination0.82670912
98MP0002111_abnormal_tail_morphology0.82220057
99MP0009931_abnormal_skin_appearance0.82061567
100MP0002429_abnormal_blood_cell0.81089108
101MP0000681_abnormal_thyroid_gland0.80937291
102MP0005623_abnormal_meninges_morphology0.80006734
103MP0003436_decreased_susceptibility_to0.79975706
104MP0000858_altered_metastatic_potential0.79746656
105MP0002092_abnormal_eye_morphology0.79406670
106MP0000477_abnormal_intestine_morphology0.79143636
107MP0001145_abnormal_male_reproductive0.78979696
108MP0002877_abnormal_melanocyte_morpholog0.78550222
109MP0003315_abnormal_perineum_morphology0.78235384
110MP0003935_abnormal_craniofacial_develop0.77024268
111MP0004185_abnormal_adipocyte_glucose0.76853296
112MP0004087_abnormal_muscle_fiber0.75145216
113MP0002060_abnormal_skin_morphology0.75041455
114MP0000358_abnormal_cell_content/0.73285263
115MP0002098_abnormal_vibrissa_morphology0.73219991
116MP0002697_abnormal_eye_size0.73176073
117MP0004133_heterotaxia0.72760404
118MP0004947_skin_inflammation0.72687280
119MP0003329_amyloid_beta_deposits0.72267860
120MP0000716_abnormal_immune_system0.71410553
121MP0002970_abnormal_white_adipose0.71132800
122MP0002089_abnormal_postnatal_growth/wei0.70710011
123MP0000750_abnormal_muscle_regeneration0.69665823
124MP0001216_abnormal_epidermal_layer0.69242239
125MP0000579_abnormal_nail_morphology0.69074102
126MP0002269_muscular_atrophy0.66718813
127MP0002932_abnormal_joint_morphology0.65826196
128MP0000432_abnormal_head_morphology0.65542819
129MP0003861_abnormal_nervous_system0.65069109
130MP0005670_abnormal_white_adipose0.64569634
131MP0002405_respiratory_system_inflammati0.63691329
132MP0001784_abnormal_fluid_regulation0.63543116
133MP0003091_abnormal_cell_migration0.61952008
134MP0001800_abnormal_humoral_immune0.61564330
135MP0003221_abnormal_cardiomyocyte_apopto0.60128693

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)3.74260932
2Selective tooth agenesis (HP:0001592)3.39332273
3Hyperacusis (HP:0010780)3.27056643
4Obstructive sleep apnea (HP:0002870)3.06588810
5Broad face (HP:0000283)2.87978121
6Increased nuchal translucency (HP:0010880)2.87204377
7Abnormality of the fingertips (HP:0001211)2.80501123
8Abnormality of the astrocytes (HP:0100707)2.80245408
9Astrocytoma (HP:0009592)2.80245408
10Short 4th metacarpal (HP:0010044)2.72081079
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.72081079
12Disproportionate tall stature (HP:0001519)2.67470281
13Basal cell carcinoma (HP:0002671)2.65295578
14Medulloblastoma (HP:0002885)2.64093701
15Abnormal gallbladder physiology (HP:0012438)2.62457270
16Cholecystitis (HP:0001082)2.62457270
17Long eyelashes (HP:0000527)2.59351481
18Proximal placement of thumb (HP:0009623)2.58743986
19Renal duplication (HP:0000075)2.56997061
20Deviation of the thumb (HP:0009603)2.55422222
21Dysmetric saccades (HP:0000641)2.48396355
22Birth length less than 3rd percentile (HP:0003561)2.47739436
23Patellar aplasia (HP:0006443)2.47241465
24Abnormality of the aortic arch (HP:0012303)2.47075820
25Skin tags (HP:0010609)2.41570528
26Abnormal number of incisors (HP:0011064)2.39339710
27Achilles tendon contracture (HP:0001771)2.38822268
28Abnormality of the distal phalanx of the thumb (HP:0009617)2.38237915
29Broad distal phalanx of finger (HP:0009836)2.37689024
30Prominent nose (HP:0000448)2.36649996
31High pitched voice (HP:0001620)2.36242378
32Rib fusion (HP:0000902)2.35139685
33Progressive muscle weakness (HP:0003323)2.34076705
34Abnormality of the lower motor neuron (HP:0002366)2.33922488
35Degeneration of anterior horn cells (HP:0002398)2.33486774
36Abnormality of the anterior horn cell (HP:0006802)2.33486774
37Distal lower limb amyotrophy (HP:0008944)2.32675274
38Abnormality of the phalanges of the hallux (HP:0010057)2.30152516
39Aplasia/Hypoplasia of the patella (HP:0006498)2.28334061
40Shallow orbits (HP:0000586)2.23120355
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.22974718
42Septate vagina (HP:0001153)2.22900319
43Cerebral aneurysm (HP:0004944)2.21704416
44Increased density of long bones (HP:0006392)2.21688540
45Preauricular skin tag (HP:0000384)2.21222272
46Urethral obstruction (HP:0000796)2.20569717
47Colon cancer (HP:0003003)2.20108572
48Neoplasm of striated muscle (HP:0009728)2.19280634
49Neoplasm of the oral cavity (HP:0100649)2.19059979
50Glioma (HP:0009733)2.18939977
51Broad palm (HP:0001169)2.18305024
52Truncus arteriosus (HP:0001660)2.17408609
53Abnormality of the thoracic spine (HP:0100711)2.09462845
54Protrusio acetabuli (HP:0003179)2.08548430
55Abnormality of the Achilles tendon (HP:0005109)2.08219482
56Pseudobulbar signs (HP:0002200)2.08010689
57Hand muscle atrophy (HP:0009130)2.07825610
58Genu recurvatum (HP:0002816)2.06574138
59Turricephaly (HP:0000262)2.05616140
60Rhabdomyosarcoma (HP:0002859)2.05449574
61Ulnar bowing (HP:0003031)2.05238113
62Breast hypoplasia (HP:0003187)2.04793564
63Trigonocephaly (HP:0000243)2.03823539
64Bowel incontinence (HP:0002607)2.03092461
65Deep palmar crease (HP:0006191)2.02707450
66Facial hemangioma (HP:0000329)2.01992371
67Increased connective tissue (HP:0009025)2.00527538
68High anterior hairline (HP:0009890)2.00298354
69Myopathic facies (HP:0002058)1.99913679
70Broad thumb (HP:0011304)1.99655864
71Trismus (HP:0000211)1.99575675
72Abnormality of the 4th metacarpal (HP:0010012)1.98642045
73Thin ribs (HP:0000883)1.97610287
74Spinal muscular atrophy (HP:0007269)1.97041127
75Overlapping toe (HP:0001845)1.96942868
76Reticulocytosis (HP:0001923)1.96794421
77Cafe-au-lait spot (HP:0000957)1.95586963
78Atresia of the external auditory canal (HP:0000413)1.95057518
79Abnormality of the labia minora (HP:0012880)1.94789394
80Abnormal large intestine physiology (HP:0012700)1.93977489
81Patellar dislocation (HP:0002999)1.93643717
82Upper limb amyotrophy (HP:0009129)1.92896586
83Distal upper limb amyotrophy (HP:0007149)1.92896586
84Missing ribs (HP:0000921)1.92692837
85Ectopic kidney (HP:0000086)1.91715449
86Volvulus (HP:0002580)1.91313054
87Ankle contracture (HP:0006466)1.91162177
88Abnormality of the columella (HP:0009929)1.90975929
89Heterotopia (HP:0002282)1.90902473
90Progressive external ophthalmoplegia (HP:0000590)1.87767124
91Ragged-red muscle fibers (HP:0003200)1.87264259
92Advanced eruption of teeth (HP:0006288)1.86585941
93Gastrointestinal carcinoma (HP:0002672)1.83992720
94Malignant gastrointestinal tract tumors (HP:0006749)1.83992720
95Atrophy/Degeneration involving motor neurons (HP:0007373)1.83090831
96Dislocated radial head (HP:0003083)1.82499739
97Renovascular hypertension (HP:0100817)1.82177406
98Aplasia/hypoplasia of the humerus (HP:0006507)1.82104542
99Insomnia (HP:0100785)1.82095256
100Unilateral renal agenesis (HP:0000122)1.81687254
101Absent thumb (HP:0009777)1.80850546
102Short humerus (HP:0005792)1.80830775
103Bowel diverticulosis (HP:0005222)1.80590740
104Lower limb amyotrophy (HP:0007210)1.80183783
105Hypercortisolism (HP:0001578)1.80027827
106Impulsivity (HP:0100710)1.79937016
107Adenoma sebaceum (HP:0009720)1.79262440
108Angiofibromas (HP:0010615)1.79262440
109Abnormality of the distal phalanges of the toes (HP:0010182)1.78755108
110Elfin facies (HP:0004428)1.78412295
111Abnormality of the salivary glands (HP:0010286)1.78180365
112Flat acetabular roof (HP:0003180)1.77901744
113Short 5th finger (HP:0009237)1.77782456
114Peripheral hypomyelination (HP:0007182)1.77631397
115Vertebral compression fractures (HP:0002953)1.77049052
116Carpal bone hypoplasia (HP:0001498)1.76749103
117Neoplasm of the pancreas (HP:0002894)1.76658770
118Premature skin wrinkling (HP:0100678)1.76614406
119Hyperparathyroidism (HP:0000843)1.75852519
120Annular pancreas (HP:0001734)1.75636150
121Myelodysplasia (HP:0002863)1.74044811
122Stridor (HP:0010307)1.73954253
123Squamous cell carcinoma (HP:0002860)1.73591054
124Cutis marmorata (HP:0000965)1.73220842
125Asymmetry of the thorax (HP:0001555)1.72919574
126Abnormality of the calcaneus (HP:0008364)1.72874278
127Self-mutilation (HP:0000742)1.72720346
128Absent radius (HP:0003974)1.72653392
129Anal stenosis (HP:0002025)1.72408862
130Multiple enchondromatosis (HP:0005701)1.72404331
131Germ cell neoplasia (HP:0100728)1.71877141
132Biconcave vertebral bodies (HP:0004586)1.71366502
133Pointed chin (HP:0000307)1.70942307
134Broad phalanges of the hand (HP:0009768)1.69807548
135Arnold-Chiari malformation (HP:0002308)1.69403371
136Abnormality of the radial head (HP:0003995)1.69083941
137Back pain (HP:0003418)1.68039876
138Slender long bone (HP:0003100)1.67385177
139Intestinal fistula (HP:0100819)1.67217128
140Vertebral fusion (HP:0002948)1.66728807
141Short phalanx of the thumb (HP:0009660)1.66637284
142Thoracic kyphosis (HP:0002942)1.65316228
143Hemorrhage of the eye (HP:0011885)1.64961529
144Athetosis (HP:0002305)1.64843984
145Metaphyseal cupping (HP:0003021)1.64456274
146Cutaneous melanoma (HP:0012056)1.63695640
147Supernumerary ribs (HP:0005815)1.63326898
148Sparse lateral eyebrow (HP:0005338)1.63254042
149Skull defect (HP:0001362)1.62208791
150Thin bony cortex (HP:0002753)1.62163975
151Long palpebral fissure (HP:0000637)1.61976781
152Spina bifida occulta (HP:0003298)1.61975017
153Overriding aorta (HP:0002623)1.61926001
154Tracheoesophageal fistula (HP:0002575)1.60855309
155Precocious puberty (HP:0000826)1.59946001
156Cellulitis (HP:0100658)1.59166824
157Absent forearm bone (HP:0003953)1.59155981
158Aplasia involving forearm bones (HP:0009822)1.59155981
159Natal tooth (HP:0000695)1.58699400
160Mitral regurgitation (HP:0001653)1.58144611
161Ankyloglossia (HP:0010296)1.57264343
162Difficulty climbing stairs (HP:0003551)1.57146944
163Hammertoe (HP:0001765)1.57127781
164Abnormality of chromosome segregation (HP:0002916)1.56129457
165Segmental peripheral demyelination/remyelination (HP:0003481)1.54082181
166Hypertensive crisis (HP:0100735)1.53886501
167Neuronal loss in central nervous system (HP:0002529)1.53050352

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.11394830
2SMG14.71432920
3EEF2K3.48632229
4MAP3K103.45404351
5PRPF4B3.37033640
6CDC73.33806178
7TRIB33.02240008
8NEK22.67014652
9PKN22.58128189
10IRAK32.38851351
11BRD42.20867380
12ERN12.16342671
13BUB12.13115871
14ICK2.09431751
15WEE11.99175346
16MAP4K11.94891392
17STK101.87021957
18NME21.74479240
19TESK21.72033127
20CDK71.71819734
21TAOK21.71646675
22CDK41.67435224
23TTK1.58548710
24NEK11.56638115
25PASK1.54051530
26RPS6KB21.49863311
27ALK1.49458907
28FGFR41.47520966
29MTOR1.47048578
30TSSK61.44749992
31PAK41.37184699
32SIK31.31101999
33TAOK11.29888644
34MAP3K81.27974055
35ATR1.27373122
36RPS6KA41.19960107
37CHEK11.19196570
38PLK11.18163432
39LATS21.15390152
40KSR21.13922315
41ARAF1.13311010
42SCYL21.11604028
43CDK61.10175655
44LRRK21.07445985
45EPHA21.03966050
46PTK61.03775510
47MAP3K131.03166830
48TTN1.01103612
49MARK21.00187750
50BMX0.98643456
51GRK60.97973514
52AURKB0.94334080
53CDK20.93872061
54VRK20.93797897
55PRKD20.93374142
56PDGFRA0.92808559
57CHEK20.90484057
58SIK20.86223404
59RIPK10.85998961
60MAP3K90.85979012
61BRAF0.85930542
62MAP3K110.85841945
63TYRO30.82589077
64MAP2K30.81884138
65SRPK10.80438895
66TGFBR10.80251710
67HIPK20.78986012
68DYRK30.77707149
69SIK10.77171963
70PIM10.76931769
71IRAK20.75421453
72MAP3K10.75029073
73ZAP700.74992193
74ATM0.73675488
75STK40.73480518
76CAMK1D0.73478631
77PAK20.72745969
78TESK10.68477143
79CDC42BPA0.67747949
80EIF2AK10.65955669
81AURKA0.65897026
82PRKD30.63671977
83BRSK10.63654352
84STK30.61026938
85FLT30.60958186
86MAPKAPK30.60875688
87FGFR10.60828993
88LATS10.58889232
89CDK10.58699876
90CAMK1G0.56725890
91IRAK40.56387039
92MAP2K20.56384665
93MKNK10.56225134
94RPS6KA20.55962130
95PTK20.55862297
96KDR0.55498612
97PAK10.55153395
98AKT20.55081073
99PIM20.54379104
100CHUK0.53948104
101BTK0.53294560
102ACVR1B0.52542803
103JAK30.51411263
104PDPK10.51372073
105MST1R0.51114546
106BRSK20.50784401
107CDK11A0.49722308
108CLK10.49693028
109MAP3K30.49618769
110MELK0.49492442
111RIPK40.49397323
112EPHB10.49037828
113PLK30.47444818
114RAF10.45613282
115MAP3K140.44872173
116MAPK110.44521376
117CSNK1E0.44377622
118RPS6KA10.43965864
119CDK80.43325001
120CDK90.43296455
121CDK150.43190805
122LMTK20.42636926
123MAPK140.42279230
124MAPK10.42113764
125MAPK100.40444508
126DAPK10.39896561
127CSNK2A20.38597616
128CDK180.38215076
129DYRK1B0.37361082
130CSF1R0.36203512
131PNCK0.34851139
132PRKCI0.34622623
133PRKDC0.34353941
134PLK40.33804710
135GSK3B0.33400917
136NTRK10.32482585
137MAPKAPK20.32195485
138RPS6KL10.32185843
139RPS6KC10.32185843
140CDK140.31115923

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.99616556
2Mismatch repair_Homo sapiens_hsa034303.23780695
3RNA transport_Homo sapiens_hsa030133.04072294
4* Spliceosome_Homo sapiens_hsa030402.92106291
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.82152995
6Base excision repair_Homo sapiens_hsa034102.76995736
7Cell cycle_Homo sapiens_hsa041102.67095505
8One carbon pool by folate_Homo sapiens_hsa006702.37459849
9mRNA surveillance pathway_Homo sapiens_hsa030152.30319395
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.18324463
11Nucleotide excision repair_Homo sapiens_hsa034201.96830004
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85326568
13Homologous recombination_Homo sapiens_hsa034401.72304512
14p53 signaling pathway_Homo sapiens_hsa041151.57073122
15Chronic myeloid leukemia_Homo sapiens_hsa052201.51858054
16Prion diseases_Homo sapiens_hsa050201.48986648
17RNA degradation_Homo sapiens_hsa030181.46025804
18Notch signaling pathway_Homo sapiens_hsa043301.45780836
19Sulfur relay system_Homo sapiens_hsa041221.43559361
20Fructose and mannose metabolism_Homo sapiens_hsa000511.43501856
21RNA polymerase_Homo sapiens_hsa030201.40412212
22Lysine degradation_Homo sapiens_hsa003101.35989211
23HTLV-I infection_Homo sapiens_hsa051661.34830785
24MicroRNAs in cancer_Homo sapiens_hsa052061.30681609
25mTOR signaling pathway_Homo sapiens_hsa041501.29954583
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29698208
27Other glycan degradation_Homo sapiens_hsa005111.28534851
28ErbB signaling pathway_Homo sapiens_hsa040121.27089326
29Fanconi anemia pathway_Homo sapiens_hsa034601.26257328
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23787223
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.22646326
32Small cell lung cancer_Homo sapiens_hsa052221.22241661
33Acute myeloid leukemia_Homo sapiens_hsa052211.20611047
34Epstein-Barr virus infection_Homo sapiens_hsa051691.19970614
35Viral carcinogenesis_Homo sapiens_hsa052031.19921813
36Thyroid cancer_Homo sapiens_hsa052161.19332173
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.18762425
38Pyrimidine metabolism_Homo sapiens_hsa002401.18703544
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.17966894
40Herpes simplex infection_Homo sapiens_hsa051681.14935098
41Antigen processing and presentation_Homo sapiens_hsa046121.12419655
42Ribosome_Homo sapiens_hsa030101.11683163
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09260835
44Basal cell carcinoma_Homo sapiens_hsa052171.07277333
45Oocyte meiosis_Homo sapiens_hsa041141.06036895
46Colorectal cancer_Homo sapiens_hsa052101.05738038
47Adherens junction_Homo sapiens_hsa045201.04724878
48Non-homologous end-joining_Homo sapiens_hsa034501.03874560
49Hippo signaling pathway_Homo sapiens_hsa043901.03335943
50Central carbon metabolism in cancer_Homo sapiens_hsa052301.02299810
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01860095
52Non-small cell lung cancer_Homo sapiens_hsa052231.00919934
53Bladder cancer_Homo sapiens_hsa052191.00875363
54Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98721100
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98472585
56Biosynthesis of amino acids_Homo sapiens_hsa012300.98228285
57Primary immunodeficiency_Homo sapiens_hsa053400.96908302
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95377717
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94528078
60Carbon metabolism_Homo sapiens_hsa012000.93588400
61B cell receptor signaling pathway_Homo sapiens_hsa046620.91058513
62Basal transcription factors_Homo sapiens_hsa030220.90391978
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.90371238
64Viral myocarditis_Homo sapiens_hsa054160.88309210
65Shigellosis_Homo sapiens_hsa051310.85403581
66Vitamin B6 metabolism_Homo sapiens_hsa007500.85259306
67Proteoglycans in cancer_Homo sapiens_hsa052050.85023910
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.82797612
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.82182373
70Hepatitis B_Homo sapiens_hsa051610.81886546
71Apoptosis_Homo sapiens_hsa042100.80154851
72Pancreatic cancer_Homo sapiens_hsa052120.79728351
73Estrogen signaling pathway_Homo sapiens_hsa049150.78594827
74Galactose metabolism_Homo sapiens_hsa000520.77933622
75Endometrial cancer_Homo sapiens_hsa052130.77571415
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77100215
77Hepatitis C_Homo sapiens_hsa051600.77005890
78VEGF signaling pathway_Homo sapiens_hsa043700.75342185
79Choline metabolism in cancer_Homo sapiens_hsa052310.72614680
80Inositol phosphate metabolism_Homo sapiens_hsa005620.72588803
81TGF-beta signaling pathway_Homo sapiens_hsa043500.72579977
82Hedgehog signaling pathway_Homo sapiens_hsa043400.71556969
83GnRH signaling pathway_Homo sapiens_hsa049120.69558192
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69145645
85HIF-1 signaling pathway_Homo sapiens_hsa040660.69030649
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68812961
87T cell receptor signaling pathway_Homo sapiens_hsa046600.67776616
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.67077491
89Pathways in cancer_Homo sapiens_hsa052000.66719977
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.64327343
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63655503
92Prostate cancer_Homo sapiens_hsa052150.63550161
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63406616
94Pentose phosphate pathway_Homo sapiens_hsa000300.63373784
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63276982
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62829096
97Long-term potentiation_Homo sapiens_hsa047200.62588949
98Selenocompound metabolism_Homo sapiens_hsa004500.61592002
99Measles_Homo sapiens_hsa051620.59846956
100Vibrio cholerae infection_Homo sapiens_hsa051100.59846491
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58491231
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.57885921
103Glioma_Homo sapiens_hsa052140.57743420
104Endocytosis_Homo sapiens_hsa041440.57646663
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57457882
106Proteasome_Homo sapiens_hsa030500.56552905
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.56377088
108Melanogenesis_Homo sapiens_hsa049160.55928601
109Legionellosis_Homo sapiens_hsa051340.54218618
110Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54046484
111Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53976952
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.53673026
113AMPK signaling pathway_Homo sapiens_hsa041520.53339017
114Glucagon signaling pathway_Homo sapiens_hsa049220.53014712
115TNF signaling pathway_Homo sapiens_hsa046680.52919975
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51551717
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.51213150
118Renal cell carcinoma_Homo sapiens_hsa052110.51037037
119Toxoplasmosis_Homo sapiens_hsa051450.50679828
120Focal adhesion_Homo sapiens_hsa045100.50325686
121N-Glycan biosynthesis_Homo sapiens_hsa005100.50090467
122Wnt signaling pathway_Homo sapiens_hsa043100.49654112
123Insulin resistance_Homo sapiens_hsa049310.49153479
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.47791531
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47094622
126Influenza A_Homo sapiens_hsa051640.46819379
127FoxO signaling pathway_Homo sapiens_hsa040680.45591598
128Insulin signaling pathway_Homo sapiens_hsa049100.43882332
129Leishmaniasis_Homo sapiens_hsa051400.42624562
130Tight junction_Homo sapiens_hsa045300.37796639
131Dorso-ventral axis formation_Homo sapiens_hsa043200.37418602
132Prolactin signaling pathway_Homo sapiens_hsa049170.37198898
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.36892993
134Purine metabolism_Homo sapiens_hsa002300.35779195
135Osteoclast differentiation_Homo sapiens_hsa043800.35526864

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