CHEK1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.22109510
2DNA replication checkpoint (GO:0000076)5.13426068
3DNA replication initiation (GO:0006270)5.09842275
4DNA strand elongation involved in DNA replication (GO:0006271)5.05252760
5protein localization to kinetochore (GO:0034501)5.01240637
6chromatin remodeling at centromere (GO:0031055)4.99951358
7CENP-A containing nucleosome assembly (GO:0034080)4.97305192
8kinetochore organization (GO:0051383)4.91880814
9DNA strand elongation (GO:0022616)4.81839478
10telomere maintenance via semi-conservative replication (GO:0032201)4.77520116
11metaphase plate congression (GO:0051310)4.72002178
12attachment of spindle microtubules to kinetochore (GO:0008608)4.71196598
13DNA replication-independent nucleosome assembly (GO:0006336)4.57118620
14DNA replication-independent nucleosome organization (GO:0034724)4.57118620
15telomere maintenance via recombination (GO:0000722)4.57004002
16meiotic chromosome segregation (GO:0045132)4.55300615
17mitotic chromosome condensation (GO:0007076)4.50841264
18kinetochore assembly (GO:0051382)4.47823661
19DNA unwinding involved in DNA replication (GO:0006268)4.45838409
20mitotic recombination (GO:0006312)4.44237204
21protein localization to chromosome, centromeric region (GO:0071459)4.35711686
22DNA replication-dependent nucleosome organization (GO:0034723)4.31427886
23DNA replication-dependent nucleosome assembly (GO:0006335)4.31427886
24establishment of chromosome localization (GO:0051303)4.25518153
25histone exchange (GO:0043486)4.25247770
26mitotic nuclear envelope disassembly (GO:0007077)4.15873764
27nuclear pore organization (GO:0006999)4.08798698
28mitotic sister chromatid segregation (GO:0000070)4.05098388
29nuclear pore complex assembly (GO:0051292)3.99492361
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.96497004
31telomere maintenance via telomere lengthening (GO:0010833)3.95680401
32nucleotide-excision repair, DNA gap filling (GO:0006297)3.90262800
33nuclear envelope disassembly (GO:0051081)3.83794809
34membrane disassembly (GO:0030397)3.83794809
35maturation of 5.8S rRNA (GO:0000460)3.83186784
36maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.71579877
37regulation of spindle organization (GO:0090224)3.71077895
38sister chromatid segregation (GO:0000819)3.67839415
39protein K6-linked ubiquitination (GO:0085020)3.66203297
40nucleobase biosynthetic process (GO:0046112)3.64077651
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.61633021
42spindle checkpoint (GO:0031577)3.61582863
43mismatch repair (GO:0006298)3.60233002
44chromatin assembly or disassembly (GO:0006333)3.58711395
45positive regulation of chromosome segregation (GO:0051984)3.56361599
46chromosome segregation (GO:0007059)3.55844809
47mitotic sister chromatid cohesion (GO:0007064)3.54228478
48synapsis (GO:0007129)3.53063841
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.50541144
50regulation of sister chromatid cohesion (GO:0007063)3.49582089
51regulation of DNA endoreduplication (GO:0032875)3.44055424
52protein localization to chromosome (GO:0034502)3.43825745
53regulation of chromosome segregation (GO:0051983)3.43626959
54folic acid-containing compound biosynthetic process (GO:0009396)3.41326642
55regulation of mitotic spindle checkpoint (GO:1903504)3.41282714
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41282714
57regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40775574
58purine nucleobase biosynthetic process (GO:0009113)3.40092665
59regulation of mitotic metaphase/anaphase transition (GO:0030071)3.39452893
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.39412074
61negative regulation of chromosome segregation (GO:0051985)3.38218705
62negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.37647262
63negative regulation of sister chromatid segregation (GO:0033046)3.37647262
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.37647262
65negative regulation of mitotic sister chromatid segregation (GO:0033048)3.37647262
66spindle assembly checkpoint (GO:0071173)3.34876634
67ribosome assembly (GO:0042255)3.33426987
68DNA double-strand break processing (GO:0000729)3.33207029
69DNA ligation (GO:0006266)3.32768079
70mitotic spindle checkpoint (GO:0071174)3.32468305
71somatic hypermutation of immunoglobulin genes (GO:0016446)3.31756001
72somatic diversification of immune receptors via somatic mutation (GO:0002566)3.31756001
73replication fork processing (GO:0031297)3.30634827
74telomere maintenance (GO:0000723)3.29164934
75IMP biosynthetic process (GO:0006188)3.28303067
76mitotic spindle assembly checkpoint (GO:0007094)3.27973734
77telomere organization (GO:0032200)3.27051391
78translesion synthesis (GO:0019985)3.25564529
79regulation of mitotic spindle organization (GO:0060236)3.25537440
80ATP-dependent chromatin remodeling (GO:0043044)3.23835024
81regulation of mitotic sister chromatid separation (GO:0010965)3.22973775
82regulation of mitotic sister chromatid segregation (GO:0033047)3.22973775
83regulation of sister chromatid segregation (GO:0033045)3.22973775
84* regulation of double-strand break repair via homologous recombination (GO:0010569)3.20646497
85positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.19802206
86positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.19802206
87positive regulation of mitotic sister chromatid separation (GO:1901970)3.19802206
88DNA geometric change (GO:0032392)3.19241325
89postreplication repair (GO:0006301)3.18800809
90regulation of histone H3-K9 methylation (GO:0051570)3.18482835
91DNA duplex unwinding (GO:0032508)3.18409290
92regulation of centriole replication (GO:0046599)3.17594539
93IMP metabolic process (GO:0046040)3.15011582
94DNA synthesis involved in DNA repair (GO:0000731)3.13497810
95non-recombinational repair (GO:0000726)3.12303959
96double-strand break repair via nonhomologous end joining (GO:0006303)3.12303959
97transcription-coupled nucleotide-excision repair (GO:0006283)3.10895182
98regulation of helicase activity (GO:0051095)3.10342644
99pore complex assembly (GO:0046931)3.10175069
100resolution of meiotic recombination intermediates (GO:0000712)3.05781899
101maturation of SSU-rRNA (GO:0030490)3.04342164
102establishment of integrated proviral latency (GO:0075713)3.02290251
103mitotic cell cycle (GO:0000278)3.01941008
104ribosome biogenesis (GO:0042254)3.01785175
105negative regulation of DNA-dependent DNA replication (GO:2000104)3.00434440
106regulation of meiosis I (GO:0060631)3.00266469
107positive regulation of histone H3-K4 methylation (GO:0051571)2.99783660
108* regulation of centrosome cycle (GO:0046605)2.99178270
109DNA catabolic process, exonucleolytic (GO:0000738)2.99171841
110proteasome assembly (GO:0043248)2.98076981
111* DNA replication (GO:0006260)2.97535792
112establishment of viral latency (GO:0019043)2.96711976
113mitotic G2/M transition checkpoint (GO:0044818)2.95930496
114intra-S DNA damage checkpoint (GO:0031573)2.94608192
115positive regulation of DNA-dependent DNA replication (GO:2000105)2.93831337
116nuclear envelope organization (GO:0006998)2.92648695
117ribosomal small subunit assembly (GO:0000028)2.91430753
118heterochromatin organization (GO:0070828)2.83318324
119DNA topological change (GO:0006265)2.83256402
120base-excision repair (GO:0006284)2.79997181

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.25931806
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.59747325
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.03358553
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.94886230
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00221961
6AR_21909140_ChIP-Seq_LNCAP_Human2.83150636
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.74625763
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.73582347
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70596570
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.69217469
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.50618410
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.49772981
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47362337
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33770769
15* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32839852
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.30262170
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29535498
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28397657
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27545762
20* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.19894462
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17394547
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.15473703
23VDR_23849224_ChIP-Seq_CD4+_Human2.05621517
24XRN2_22483619_ChIP-Seq_HELA_Human2.00989477
25E2F7_22180533_ChIP-Seq_HELA_Human11.4444333
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99881081
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99032974
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86552024
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83114980
30FOXP3_21729870_ChIP-Seq_TREG_Human1.80928828
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.79513324
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78158637
33DCP1A_22483619_ChIP-Seq_HELA_Human1.71045249
34TTF2_22483619_ChIP-Seq_HELA_Human1.68493339
35E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65800361
36TP63_19390658_ChIP-ChIP_HaCaT_Human1.65382160
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64546317
38GABP_19822575_ChIP-Seq_HepG2_Human1.64391348
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63400373
40RBPJ_22232070_ChIP-Seq_NCS_Mouse1.63067539
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60163659
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59056328
43ELK1_19687146_ChIP-ChIP_HELA_Human1.58316284
44ZNF274_21170338_ChIP-Seq_K562_Hela1.51458970
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50511987
46* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46499594
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45332598
48NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.45153334
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43205974
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.43161671
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42581649
52CIITA_25753668_ChIP-Seq_RAJI_Human1.39917462
53* KDM5A_27292631_Chip-Seq_BREAST_Human1.35515763
54POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33258910
55VDR_22108803_ChIP-Seq_LS180_Human1.28988091
56FUS_26573619_Chip-Seq_HEK293_Human1.27571721
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26458256
58MYC_18940864_ChIP-ChIP_HL60_Human1.25973743
59SOX2_16153702_ChIP-ChIP_HESCs_Human1.25385977
60* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25292139
61* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23894889
62NANOG_16153702_ChIP-ChIP_HESCs_Human1.21260667
63* SRF_21415370_ChIP-Seq_HL-1_Mouse1.19688695
64SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15100163
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12864959
66MYC_22102868_ChIP-Seq_BL_Human1.12712554
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12298576
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11048119
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11021669
70TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.10717645
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10001510
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.08625512
73SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07601981
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07334203
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05911455
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04893958
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03912089
78SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.02841283
79* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02642696
80STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96579267
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95521313
82HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.95109839
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93104538
84* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.93029658
85NOTCH1_21737748_ChIP-Seq_TLL_Human0.92596841
86IGF1R_20145208_ChIP-Seq_DFB_Human0.92428126
87DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.92391930
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.92147142
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90774928
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90774928
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90774928
92PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89612518
93* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87820797
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86567896
95FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85844446
96TFEB_21752829_ChIP-Seq_HELA_Human0.85785626
97NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.83458544
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83254381
99SOX17_20123909_ChIP-Seq_XEN_Mouse0.77820956
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77672413
101KAP1_22055183_ChIP-Seq_ESCs_Mouse0.74806752
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.74610816
103* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.73579395
104FLI1_27457419_Chip-Seq_LIVER_Mouse0.72888321
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72293419
106CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71953138
107TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71664700
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70668246
109GATA1_26923725_Chip-Seq_HPCs_Mouse0.70497160
110TCF3_18692474_ChIP-Seq_MESCs_Mouse0.68721760
111* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.67965526
112IRF1_19129219_ChIP-ChIP_H3396_Human0.67729786
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.66995981
114EWS_26573619_Chip-Seq_HEK293_Human0.66823675
115* SPI1_23547873_ChIP-Seq_NB4_Human0.66588182
116* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.65738984
117ESR1_15608294_ChIP-ChIP_MCF-7_Human0.65031613
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.64816982
119SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.63272993
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.61546585
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.60409410
122ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.58363365

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.51372742
2* MP0003693_abnormal_embryo_hatching4.93556610
3MP0003111_abnormal_nucleus_morphology4.64490095
4MP0008057_abnormal_DNA_replication4.55578794
5* MP0004957_abnormal_blastocyst_morpholog4.22369057
6* MP0003077_abnormal_cell_cycle4.20492256
7MP0008058_abnormal_DNA_repair3.63577756
8MP0008877_abnormal_DNA_methylation3.21776997
9MP0008007_abnormal_cellular_replicative2.93373918
10MP0003718_maternal_effect2.76763374
11MP0003123_paternal_imprinting2.70321185
12* MP0008932_abnormal_embryonic_tissue2.70136406
13MP0002396_abnormal_hematopoietic_system2.35444638
14* MP0000350_abnormal_cell_proliferation2.22689720
15MP0001730_embryonic_growth_arrest2.14716819
16MP0008789_abnormal_olfactory_epithelium2.08903883
17MP0003786_premature_aging1.97097394
18MP0003121_genomic_imprinting1.91314329
19MP0010307_abnormal_tumor_latency1.88300781
20MP0002210_abnormal_sex_determination1.79335000
21MP0005394_taste/olfaction_phenotype1.72643978
22MP0005499_abnormal_olfactory_system1.72643978
23MP0000490_abnormal_crypts_of1.72456945
24MP0001672_abnormal_embryogenesis/_devel1.71832457
25MP0005380_embryogenesis_phenotype1.71832457
26MP0001697_abnormal_embryo_size1.71166188
27MP0006292_abnormal_olfactory_placode1.70541609
28MP0010352_gastrointestinal_tract_polyps1.66384620
29MP0002102_abnormal_ear_morphology1.66038835
30MP0002234_abnormal_pharynx_morphology1.61534988
31* MP0002085_abnormal_embryonic_tissue1.61200263
32MP0001119_abnormal_female_reproductive1.53189308
33MP0001929_abnormal_gametogenesis1.52225454
34MP0000653_abnormal_sex_gland1.48019719
35MP0002084_abnormal_developmental_patter1.47332219
36MP0003890_abnormal_embryonic-extraembry1.46586817
37MP0001145_abnormal_male_reproductive1.44442414
38MP0003984_embryonic_growth_retardation1.43806343
39MP0003315_abnormal_perineum_morphology1.43169938
40* MP0002019_abnormal_tumor_incidence1.42768447
41MP0002088_abnormal_embryonic_growth/wei1.39008349
42* MP0002080_prenatal_lethality1.38326920
43* MP0000313_abnormal_cell_death1.33675005
44MP0004808_abnormal_hematopoietic_stem1.30799536
45MP0003937_abnormal_limbs/digits/tail_de1.29658332
46MP0003136_yellow_coat_color1.29640691
47MP0002086_abnormal_extraembryonic_tissu1.28138255
48MP0002233_abnormal_nose_morphology1.24875631
49MP0004197_abnormal_fetal_growth/weight/1.24290460
50MP0003787_abnormal_imprinting1.19208844
51MP0006072_abnormal_retinal_apoptosis1.17189367
52MP0003567_abnormal_fetal_cardiomyocyte1.17124635
53MP0010030_abnormal_orbit_morphology1.15465494
54MP0002697_abnormal_eye_size1.12723852
55MP0000566_synostosis1.12633875
56MP0001293_anophthalmia1.11051764
57MP0000631_abnormal_neuroendocrine_gland1.07547552
58* MP0003699_abnormal_female_reproductive1.05674938
59MP0002653_abnormal_ependyma_morphology1.05156891
60MP0001529_abnormal_vocalization1.03938279
61MP0003763_abnormal_thymus_physiology0.98722316
62MP0006035_abnormal_mitochondrial_morpho0.97855377
63MP0002160_abnormal_reproductive_system0.97398980
64MP0001346_abnormal_lacrimal_gland0.95953004
65MP0004147_increased_porphyrin_level0.93765788
66MP0005397_hematopoietic_system_phenotyp0.93419091
67MP0001545_abnormal_hematopoietic_system0.93419091
68MP0009379_abnormal_foot_pigmentation0.93173194
69MP0009697_abnormal_copulation0.91975733
70MP0005389_reproductive_system_phenotype0.91914453
71MP0000703_abnormal_thymus_morphology0.86066288
72MP0009333_abnormal_splenocyte_physiolog0.85167600
73MP0003119_abnormal_digestive_system0.84951375
74MP0005395_other_phenotype0.84245271
75MP0002163_abnormal_gland_morphology0.84151085
76MP0000647_abnormal_sebaceous_gland0.83579340
77MP0000427_abnormal_hair_cycle0.82477111
78MP0004264_abnormal_extraembryonic_tissu0.82204971
79MP0003941_abnormal_skin_development0.81308194
80MP0002751_abnormal_autonomic_nervous0.81057278
81MP0001915_intracranial_hemorrhage0.80603010
82MP0000358_abnormal_cell_content/0.79987648
83MP0005076_abnormal_cell_differentiation0.79473221
84MP0004133_heterotaxia0.79317448
85MP0005391_vision/eye_phenotype0.79258746
86MP0002249_abnormal_larynx_morphology0.77715724
87MP0000537_abnormal_urethra_morphology0.77645620
88MP0009672_abnormal_birth_weight0.77578476
89MP0002161_abnormal_fertility/fecundity0.75526057
90MP0002111_abnormal_tail_morphology0.75447906
91MP0005384_cellular_phenotype0.74991860
92MP0001286_abnormal_eye_development0.74862431
93MP0002398_abnormal_bone_marrow0.74149243
94MP0005621_abnormal_cell_physiology0.72885338
95MP0003698_abnormal_male_reproductive0.71282834
96MP0000432_abnormal_head_morphology0.70709002
97MP0005408_hypopigmentation0.70215014
98MP0005451_abnormal_body_composition0.69964640
99MP0003755_abnormal_palate_morphology0.69540367
100MP0000689_abnormal_spleen_morphology0.68563538
101MP0001919_abnormal_reproductive_system0.68430918
102MP0009053_abnormal_anal_canal0.67852454
103MP0002722_abnormal_immune_system0.67720019
104MP0003938_abnormal_ear_development0.67609290
105MP0001188_hyperpigmentation0.65573226
106MP0009703_decreased_birth_body0.62049922
107MP0002177_abnormal_outer_ear0.61413677
108MP0002075_abnormal_coat/hair_pigmentati0.60610928
109MP0000579_abnormal_nail_morphology0.60094909
110MP0003646_muscle_fatigue0.59924188
111MP0000762_abnormal_tongue_morphology0.58978439
112MP0008995_early_reproductive_senescence0.58977315
113MP0002938_white_spotting0.58755845
114MP0008770_decreased_survivor_rate0.57926681
115MP0002092_abnormal_eye_morphology0.56514115
116MP0002114_abnormal_axial_skeleton0.56335061
117* MP0003936_abnormal_reproductive_system0.56302559
118MP0003935_abnormal_craniofacial_develop0.55960707
119MP0002095_abnormal_skin_pigmentation0.55424713
120MP0000428_abnormal_craniofacial_morphol0.54536648
121MP0003186_abnormal_redox_activity0.54013075
122MP0003806_abnormal_nucleotide_metabolis0.53843042
123MP0006054_spinal_hemorrhage0.53738359
124MP0001186_pigmentation_phenotype0.53287315
125MP0000477_abnormal_intestine_morphology0.52952146
126MP0002429_abnormal_blood_cell0.52658738
127MP0000858_altered_metastatic_potential0.51811697
128MP0000049_abnormal_middle_ear0.50975234
129MP0003861_abnormal_nervous_system0.50855470

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.20398680
2Chromsome breakage (HP:0040012)5.67912478
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.31166286
4Breast hypoplasia (HP:0003187)4.58303603
5Abnormality of chromosome stability (HP:0003220)4.41905113
6Patellar aplasia (HP:0006443)3.85128154
7Abnormality of the preputium (HP:0100587)3.84932882
8Meckel diverticulum (HP:0002245)3.83502193
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.70247453
10Abnormality of the ileum (HP:0001549)3.64484085
11Aplasia/Hypoplasia of the patella (HP:0006498)3.58334158
12Medulloblastoma (HP:0002885)3.49457418
13Abnormality of the labia minora (HP:0012880)3.47971850
14Colon cancer (HP:0003003)3.18970609
15Duodenal stenosis (HP:0100867)3.14800159
16Small intestinal stenosis (HP:0012848)3.14800159
17Reticulocytopenia (HP:0001896)3.11696525
18Rhabdomyosarcoma (HP:0002859)3.06379125
19Absent radius (HP:0003974)3.04411230
20Selective tooth agenesis (HP:0001592)3.00517055
21Ectopic kidney (HP:0000086)3.00066547
22Myelodysplasia (HP:0002863)2.96259019
23Oral leukoplakia (HP:0002745)2.91243926
24Impulsivity (HP:0100710)2.88295750
25Supernumerary spleens (HP:0009799)2.87618469
26Absent forearm bone (HP:0003953)2.86528995
27Aplasia involving forearm bones (HP:0009822)2.86528995
28Agnosia (HP:0010524)2.82075372
29Ependymoma (HP:0002888)2.78621723
30Sloping forehead (HP:0000340)2.76138474
31Facial hemangioma (HP:0000329)2.71665659
32Aplastic anemia (HP:0001915)2.67874552
33Absent thumb (HP:0009777)2.64015165
34Carpal bone hypoplasia (HP:0001498)2.62290624
35Degeneration of anterior horn cells (HP:0002398)2.54710169
36Abnormality of the anterior horn cell (HP:0006802)2.54710169
37Bone marrow hypocellularity (HP:0005528)2.53751190
38Abnormality of the carotid arteries (HP:0005344)2.53392018
39Clubbing of toes (HP:0100760)2.52833179
40Abnormality of the duodenum (HP:0002246)2.52553347
41Septo-optic dysplasia (HP:0100842)2.49313297
42Duplicated collecting system (HP:0000081)2.45032806
43Nephroblastoma (Wilms tumor) (HP:0002667)2.42357738
44Abnormal lung lobation (HP:0002101)2.41858395
45Short thumb (HP:0009778)2.40096368
46Triphalangeal thumb (HP:0001199)2.36009663
47Abnormality of the renal collecting system (HP:0004742)2.35061473
48Volvulus (HP:0002580)2.33224871
49Aplasia/Hypoplasia of the sternum (HP:0006714)2.27647365
50Premature ovarian failure (HP:0008209)2.27548760
51Embryonal renal neoplasm (HP:0011794)2.27453568
52Horseshoe kidney (HP:0000085)2.27245596
53Secondary amenorrhea (HP:0000869)2.23349668
54Shawl scrotum (HP:0000049)2.23347092
55Cafe-au-lait spot (HP:0000957)2.23193249
56Capillary hemangiomas (HP:0005306)2.21902163
57Acute myeloid leukemia (HP:0004808)2.18695563
58Neoplasm of the oral cavity (HP:0100649)2.15747047
59Atresia of the external auditory canal (HP:0000413)2.14287957
60Multiple enchondromatosis (HP:0005701)2.13607753
61Neoplasm of striated muscle (HP:0009728)2.13123698
62Abnormal spermatogenesis (HP:0008669)2.10849794
63Slender long bone (HP:0003100)2.10047600
64Abnormality of DNA repair (HP:0003254)2.10010653
65Tracheoesophageal fistula (HP:0002575)2.09444068
66Breast aplasia (HP:0100783)2.07927294
67Premature graying of hair (HP:0002216)2.07802008
68Absent septum pellucidum (HP:0001331)2.07180667
69Rough bone trabeculation (HP:0100670)2.06833609
70Abnormality of alanine metabolism (HP:0010916)2.05368524
71Hyperalaninemia (HP:0003348)2.05368524
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.05368524
73Neoplasm of the pancreas (HP:0002894)2.04629255
74Abnormal number of incisors (HP:0011064)2.02620807
75Increased nuchal translucency (HP:0010880)2.02516041
76Increased hepatocellular lipid droplets (HP:0006565)2.02496910
77High pitched voice (HP:0001620)2.01761557
78Squamous cell carcinoma (HP:0002860)2.01606201
79Aplasia/Hypoplasia of the breasts (HP:0010311)2.00425805
80Papillary thyroid carcinoma (HP:0002895)1.98906011
81Oligodactyly (hands) (HP:0001180)1.98237970
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97678994
83Hypoplasia of the pons (HP:0012110)1.97235623
84Glioma (HP:0009733)1.96524182
85Basal cell carcinoma (HP:0002671)1.94570762
86Abnormality of the septum pellucidum (HP:0007375)1.93373132
87Abdominal situs inversus (HP:0003363)1.91920848
88Abnormality of abdominal situs (HP:0011620)1.91920848
89Aplasia/Hypoplasia of the sacrum (HP:0008517)1.91653552
9011 pairs of ribs (HP:0000878)1.90818980
91Lipid accumulation in hepatocytes (HP:0006561)1.90338659
92Abnormality of cochlea (HP:0000375)1.89753000
93Abnormality of the pons (HP:0007361)1.89747047
94Cerebral hypomyelination (HP:0006808)1.89694222
95Prominent nose (HP:0000448)1.87337837
96Cortical dysplasia (HP:0002539)1.87133162
97Deviation of the thumb (HP:0009603)1.86620930
98Pulmonary fibrosis (HP:0002206)1.86425375
99Macrocytic anemia (HP:0001972)1.85750951
100Abnormality of the astrocytes (HP:0100707)1.85422817
101Astrocytoma (HP:0009592)1.85422817
102Overlapping toe (HP:0001845)1.85089665
103Abnormality of chromosome segregation (HP:0002916)1.84634531
104Pancreatic fibrosis (HP:0100732)1.83947339
105Microretrognathia (HP:0000308)1.81922287
106Preaxial hand polydactyly (HP:0001177)1.81605561
107Proximal placement of thumb (HP:0009623)1.81578228
108Abnormality of cells of the erythroid lineage (HP:0012130)1.81341053
109Cellular immunodeficiency (HP:0005374)1.80919997
110Aplasia/Hypoplasia of the earlobes (HP:0009906)1.80570265
111Choanal atresia (HP:0000453)1.80320145
112Abnormal number of erythroid precursors (HP:0012131)1.80211370
113Microtia (HP:0008551)1.79622809
114Irregular epiphyses (HP:0010582)1.79274008
115Pancreatic cysts (HP:0001737)1.78582131
116Abnormality of the fingertips (HP:0001211)1.77703491
117Oligodactyly (HP:0012165)1.76995808
118Arteriovenous malformation (HP:0100026)1.76322224
119Pendular nystagmus (HP:0012043)1.76320827
120Type 2 muscle fiber atrophy (HP:0003554)1.76053971
121Abnormality of methionine metabolism (HP:0010901)1.75999235
122Neoplasm of the colon (HP:0100273)1.75482787
123Acute encephalopathy (HP:0006846)1.75342420
124Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74189820
125Muscle fiber atrophy (HP:0100295)1.73047933
126Dandy-Walker malformation (HP:0001305)1.72688727
127Bilateral microphthalmos (HP:0007633)1.71984634
128Molar tooth sign on MRI (HP:0002419)1.68581594
129Abnormality of midbrain morphology (HP:0002418)1.68581594
130Acute necrotizing encephalopathy (HP:0006965)1.68149468
131Facial cleft (HP:0002006)1.67908779
132Aplasia/Hypoplasia of the tongue (HP:0010295)1.67680646
133Duplication of thumb phalanx (HP:0009942)1.66275186
134Embryonal neoplasm (HP:0002898)1.64966537
135Cleft eyelid (HP:0000625)1.64475969
136Gonadotropin excess (HP:0000837)1.64101825
137Abnormality of serum amino acid levels (HP:0003112)1.63682963
138Abnormality of homocysteine metabolism (HP:0010919)1.61175622
139Homocystinuria (HP:0002156)1.61175622
140Pancytopenia (HP:0001876)1.59896664
141Increased CSF lactate (HP:0002490)1.59876464
142Hyperglycinemia (HP:0002154)1.58860072
143High anterior hairline (HP:0009890)1.58834934
144Holoprosencephaly (HP:0001360)1.58088335

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.38825301
2WEE13.94349432
3EIF2AK13.92464293
4TTK3.49304218
5BUB13.43714521
6PLK43.31705886
7NEK22.77597531
8VRK22.76017938
9SRPK12.52364092
10ACVR1B2.44645460
11PLK12.24246481
12BRSK22.18070842
13EIF2AK32.13460135
14CHEK22.11268051
15MKNK12.08395356
16NEK11.95871205
17LATS11.90344019
18TAF11.85483212
19CDK71.83813498
20VRK11.83283037
21AURKB1.80858445
22PLK31.76956230
23CDK121.76913922
24* ATR1.69324718
25CDK81.68445398
26STK38L1.65348926
27MKNK21.63521888
28TSSK61.56345639
29BRAF1.50561420
30MST41.48452701
31RPS6KB21.44948651
32BMPR1B1.41301823
33LATS21.37433789
34TRIM281.35679653
35EEF2K1.35027917
36PASK1.34940631
37MAP3K61.34211047
38CDK41.31391362
39RPS6KA41.30901002
40* CHEK11.30739174
41STK101.30285675
42DYRK31.28359200
43STK31.25018591
44CCNB11.21171434
45BRSK11.19799496
46STK161.17446000
47TLK11.16776805
48AURKA1.14001234
49WNK31.13993595
50MAP4K21.13447696
51STK41.10021248
52* ATM1.09414112
53MELK1.08206078
54ZAK1.04604348
55NME11.03727382
56TNIK0.99420903
57NME20.90533925
58* MAP3K80.89723766
59ERBB40.88502913
60CDK190.86031764
61* CDK20.86029179
62MAPKAPK30.85532902
63EIF2AK20.84983063
64MAP3K90.76205039
65WNK40.75749934
66BRD40.74141907
67PIM10.73740447
68TAOK30.72503388
69* CDK10.72315260
70MUSK0.70443025
71CDK60.66294726
72TESK20.65148348
73SCYL20.64844947
74TGFBR10.64105180
75RAF10.61312406
76CSNK2A10.56168141
77EPHA20.55666182
78CDK90.53804429
79CSNK2A20.51339868
80PAK40.50252015
81DYRK20.48446588
82BCR0.47812304
83INSRR0.47458468
84MOS0.46432866
85STK390.45844434
86MET0.45195331
87MAP3K40.43546973
88PRKCI0.43313121
89FGFR10.41045898
90MAPKAPK50.40625910
91PLK20.40087634
92PAK10.37635544
93NUAK10.37566399
94RPS6KA50.36632533
95GRK10.35343636
96NEK90.34707349
97PBK0.33714851
98CSNK1G20.33703203
99FLT30.33647648
100CLK10.33359800
101ERBB30.31543380
102CSNK1A1L0.31425359
103CDK30.30228996
104CASK0.29584930
105CSNK1D0.29118197
106CSNK1E0.29042044
107MAPK140.28812379
108CSNK1G30.27877893
109* PRKDC0.27672868
110PDK20.27571660
111OXSR10.27210328
112ABL20.27179988
113CSNK1G10.26846953
114TAOK10.26239805
115FRK0.25672060
116TEC0.24896139
117CDK11A0.24853105
118STK240.24340286
119CAMK1G0.22673747
120ALK0.22076903
121* AKT10.20602832
122CHUK0.16985973
123MAP3K50.16550726
124PNCK0.16024390
125MAPK10.15815639
126AKT20.15662209
127MAP3K100.15212194
128* GSK3B0.14605191
129LRRK20.14208725
130MTOR0.11039725

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.35417498
2Mismatch repair_Homo sapiens_hsa034304.80973183
3Homologous recombination_Homo sapiens_hsa034403.87170974
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52368435
5* Cell cycle_Homo sapiens_hsa041103.46754625
6Base excision repair_Homo sapiens_hsa034103.17153091
7RNA transport_Homo sapiens_hsa030133.10495986
8Nucleotide excision repair_Homo sapiens_hsa034203.09728194
9Fanconi anemia pathway_Homo sapiens_hsa034603.07918372
10RNA polymerase_Homo sapiens_hsa030203.00197460
11Spliceosome_Homo sapiens_hsa030403.00119185
12Non-homologous end-joining_Homo sapiens_hsa034502.70655204
13RNA degradation_Homo sapiens_hsa030182.60174271
14One carbon pool by folate_Homo sapiens_hsa006702.59617728
15Basal transcription factors_Homo sapiens_hsa030222.49049126
16Pyrimidine metabolism_Homo sapiens_hsa002402.39326109
17Ribosome_Homo sapiens_hsa030102.22407149
18Proteasome_Homo sapiens_hsa030502.18614181
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.93153639
20* p53 signaling pathway_Homo sapiens_hsa041151.80414177
21mRNA surveillance pathway_Homo sapiens_hsa030151.75376643
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47812134
23Purine metabolism_Homo sapiens_hsa002301.35572481
24Oocyte meiosis_Homo sapiens_hsa041141.23793186
25Parkinsons disease_Homo sapiens_hsa050121.20929103
26Oxidative phosphorylation_Homo sapiens_hsa001901.20761910
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13701878
28Systemic lupus erythematosus_Homo sapiens_hsa053221.09759293
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09648341
30Pyruvate metabolism_Homo sapiens_hsa006201.06144564
31Propanoate metabolism_Homo sapiens_hsa006401.04583851
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02671493
33Epstein-Barr virus infection_Homo sapiens_hsa051691.02599655
34Herpes simplex infection_Homo sapiens_hsa051681.00456879
35Steroid biosynthesis_Homo sapiens_hsa001001.00180837
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00009636
37Vitamin B6 metabolism_Homo sapiens_hsa007500.91266307
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.89438626
39MicroRNAs in cancer_Homo sapiens_hsa052060.85147870
40* Viral carcinogenesis_Homo sapiens_hsa052030.83981279
41Cysteine and methionine metabolism_Homo sapiens_hsa002700.79849580
42Thyroid cancer_Homo sapiens_hsa052160.77339649
43TGF-beta signaling pathway_Homo sapiens_hsa043500.76122391
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.74184049
45* HTLV-I infection_Homo sapiens_hsa051660.73428690
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72261973
47Folate biosynthesis_Homo sapiens_hsa007900.71877335
48Small cell lung cancer_Homo sapiens_hsa052220.69348631
49Selenocompound metabolism_Homo sapiens_hsa004500.69098535
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64969232
51Fatty acid elongation_Homo sapiens_hsa000620.64922991
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.60711684
53Antigen processing and presentation_Homo sapiens_hsa046120.59891351
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57306099
55Carbon metabolism_Homo sapiens_hsa012000.57172644
56Cyanoamino acid metabolism_Homo sapiens_hsa004600.56678720
57Colorectal cancer_Homo sapiens_hsa052100.54423027
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54085643
59Alzheimers disease_Homo sapiens_hsa050100.53380750
60Phototransduction_Homo sapiens_hsa047440.52774159
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52773208
62Pentose phosphate pathway_Homo sapiens_hsa000300.52035214
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51424366
64Biosynthesis of amino acids_Homo sapiens_hsa012300.50750565
65Hippo signaling pathway_Homo sapiens_hsa043900.47757947
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47445419
67Pancreatic cancer_Homo sapiens_hsa052120.46153344
68Butanoate metabolism_Homo sapiens_hsa006500.43499080
69Protein export_Homo sapiens_hsa030600.41567069
70Caffeine metabolism_Homo sapiens_hsa002320.40749650
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.40241984
72Hepatitis B_Homo sapiens_hsa051610.40180137
73Glutathione metabolism_Homo sapiens_hsa004800.39939865
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39478370
75Basal cell carcinoma_Homo sapiens_hsa052170.39419329
76Alcoholism_Homo sapiens_hsa050340.35601730
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34434871
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32673361
79Nitrogen metabolism_Homo sapiens_hsa009100.32380021
80Notch signaling pathway_Homo sapiens_hsa043300.31769742
81Pathways in cancer_Homo sapiens_hsa052000.29961043
82Linoleic acid metabolism_Homo sapiens_hsa005910.29831843
83Apoptosis_Homo sapiens_hsa042100.29788158
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28111207
85Vitamin digestion and absorption_Homo sapiens_hsa049770.27615777
86Measles_Homo sapiens_hsa051620.27311052
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27173293
88Primary immunodeficiency_Homo sapiens_hsa053400.26386306
89Chronic myeloid leukemia_Homo sapiens_hsa052200.25386603
90Prostate cancer_Homo sapiens_hsa052150.25236186
91Legionellosis_Homo sapiens_hsa051340.24603344
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.24166336
93Huntingtons disease_Homo sapiens_hsa050160.23962944
94Arginine and proline metabolism_Homo sapiens_hsa003300.23672762
95Ovarian steroidogenesis_Homo sapiens_hsa049130.23478101
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.22940854
97Bladder cancer_Homo sapiens_hsa052190.22873605
98Cardiac muscle contraction_Homo sapiens_hsa042600.22498989
99Circadian rhythm_Homo sapiens_hsa047100.22443573
100Adherens junction_Homo sapiens_hsa045200.22226620
101Influenza A_Homo sapiens_hsa051640.22214740
102Olfactory transduction_Homo sapiens_hsa047400.21967043
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.21387857
104Fatty acid metabolism_Homo sapiens_hsa012120.21272220
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20927160
106Peroxisome_Homo sapiens_hsa041460.20806681
107Shigellosis_Homo sapiens_hsa051310.20424827
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19771650
109N-Glycan biosynthesis_Homo sapiens_hsa005100.19392737
110Arachidonic acid metabolism_Homo sapiens_hsa005900.18614539
111Hematopoietic cell lineage_Homo sapiens_hsa046400.18469883
112Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18273892
113Hedgehog signaling pathway_Homo sapiens_hsa043400.17971115
114FoxO signaling pathway_Homo sapiens_hsa040680.17849072
115Melanoma_Homo sapiens_hsa052180.17138337
116Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.17125060
117Non-small cell lung cancer_Homo sapiens_hsa052230.16718501
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16249742
119Wnt signaling pathway_Homo sapiens_hsa043100.15453078
120Tryptophan metabolism_Homo sapiens_hsa003800.13819229
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13802921
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.13645172
123Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.12902369
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.10231887
125Lysine degradation_Homo sapiens_hsa003100.09856441
126HIF-1 signaling pathway_Homo sapiens_hsa040660.09650117
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.09409683
128Nicotine addiction_Homo sapiens_hsa050330.09126464
129mTOR signaling pathway_Homo sapiens_hsa041500.08776546
130Metabolic pathways_Homo sapiens_hsa011000.08663065
131Sulfur relay system_Homo sapiens_hsa041220.07989943
132Viral myocarditis_Homo sapiens_hsa054160.06623807
133Renin-angiotensin system_Homo sapiens_hsa046140.06218924
134PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05435546
135Ether lipid metabolism_Homo sapiens_hsa005650.05348140

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