CHD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuronal stem cell maintenance (GO:0097150)5.01423188
2dopaminergic neuron differentiation (GO:0071542)4.33423479
3histone H3-K4 trimethylation (GO:0080182)4.18321479
4mitotic chromosome condensation (GO:0007076)4.15077484
5pyrimidine nucleobase catabolic process (GO:0006208)4.11008934
6presynaptic membrane assembly (GO:0097105)3.87200424
7presynaptic membrane organization (GO:0097090)3.72938245
8lateral sprouting from an epithelium (GO:0060601)3.67607206
9histone H3-K4 methylation (GO:0051568)3.63223364
10eye photoreceptor cell differentiation (GO:0001754)3.60852610
11photoreceptor cell differentiation (GO:0046530)3.60852610
12mitotic sister chromatid cohesion (GO:0007064)3.51737616
13pre-miRNA processing (GO:0031054)3.48537049
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.46088217
15negative regulation of translation, ncRNA-mediated (GO:0040033)3.46088217
16regulation of translation, ncRNA-mediated (GO:0045974)3.46088217
17retinal ganglion cell axon guidance (GO:0031290)3.40214858
18regulation of RNA export from nucleus (GO:0046831)3.37405304
19cytoplasmic mRNA processing body assembly (GO:0033962)3.30734884
20behavioral response to nicotine (GO:0035095)3.25815373
21paraxial mesoderm development (GO:0048339)3.24068801
22mRNA splice site selection (GO:0006376)3.18284906
23nucleobase catabolic process (GO:0046113)3.18198906
24hindbrain development (GO:0030902)3.16592613
25forebrain neuron differentiation (GO:0021879)3.16140930
26axonal fasciculation (GO:0007413)3.14232283
27histone lysine methylation (GO:0034968)3.08085069
28peptidyl-lysine trimethylation (GO:0018023)3.07891924
29establishment of nucleus localization (GO:0040023)3.07494566
30establishment of mitotic spindle orientation (GO:0000132)3.05542326
31limb bud formation (GO:0060174)3.02035382
32kinetochore organization (GO:0051383)3.00984800
33positive thymic T cell selection (GO:0045059)3.00863898
34establishment of mitotic spindle localization (GO:0040001)3.00434637
35* olfactory bulb development (GO:0021772)2.99682228
36dorsal/ventral axis specification (GO:0009950)2.99631264
37regulation of somitogenesis (GO:0014807)2.98409728
38histone H3-K36 demethylation (GO:0070544)2.96338045
39microtubule depolymerization (GO:0007019)2.94576178
40central nervous system myelination (GO:0022010)2.94372645
41axon ensheathment in central nervous system (GO:0032291)2.94372645
42intraciliary transport (GO:0042073)2.93644342
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.91338545
44retina layer formation (GO:0010842)2.90670604
45interkinetic nuclear migration (GO:0022027)2.90402584
46histone H3-K9 methylation (GO:0051567)2.90220846
47negative regulation of histone methylation (GO:0031061)2.89329543
48postsynaptic membrane organization (GO:0001941)2.88664087
49primitive streak formation (GO:0090009)2.88508555
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.87029143
51sister chromatid segregation (GO:0000819)2.84862675
52chromatin remodeling at centromere (GO:0031055)2.82923023
53regulation of timing of cell differentiation (GO:0048505)2.82890217
54nucleus localization (GO:0051647)2.82560150
55neural tube formation (GO:0001841)2.80075803
56positive regulation of neuroblast proliferation (GO:0002052)2.78258298
57retinal cone cell development (GO:0046549)2.77817560
58positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.76525885
59centrosome localization (GO:0051642)2.76313783
60neuron recognition (GO:0008038)2.75681535
61photoreceptor cell maintenance (GO:0045494)2.75378077
62nonmotile primary cilium assembly (GO:0035058)2.74085628
63cell proliferation in forebrain (GO:0021846)2.74072251
64centriole replication (GO:0007099)2.72993270
65histone lysine demethylation (GO:0070076)2.70875852
66establishment of spindle orientation (GO:0051294)2.68449894
67stress granule assembly (GO:0034063)2.68424086
68positive regulation of oligodendrocyte differentiation (GO:0048714)2.67582291
69spinal cord motor neuron differentiation (GO:0021522)2.66616370
70nuclear pore complex assembly (GO:0051292)2.65784697
71embryonic retina morphogenesis in camera-type eye (GO:0060059)2.65509438
72central nervous system projection neuron axonogenesis (GO:0021952)2.65207434
73histone demethylation (GO:0016577)2.63648957
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.62526709
75histone H3-K9 modification (GO:0061647)2.61855676
76replication fork processing (GO:0031297)2.61784180
77DNA topological change (GO:0006265)2.61074805
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.60112324
79regulation of nucleobase-containing compound transport (GO:0032239)2.59804080
80somite development (GO:0061053)2.59704074
81regulation of rhodopsin mediated signaling pathway (GO:0022400)2.58656069
82epithelial cilium movement (GO:0003351)2.58654535
83negative regulation of mRNA processing (GO:0050686)2.58409146
84regulation of sister chromatid cohesion (GO:0007063)2.58007140
85histone methylation (GO:0016571)2.57928975
86rhodopsin mediated signaling pathway (GO:0016056)2.57616625
87activated T cell proliferation (GO:0050798)2.57052463
88regulation of posttranscriptional gene silencing (GO:0060147)2.56531494
89regulation of gene silencing by miRNA (GO:0060964)2.56531494
90regulation of gene silencing by RNA (GO:0060966)2.56531494
91epithelial cell fate commitment (GO:0072148)2.55829057
92DNA double-strand break processing (GO:0000729)2.55177857
93thalamus development (GO:0021794)2.54392192
94protein-DNA complex disassembly (GO:0032986)2.54221334
95nucleosome disassembly (GO:0006337)2.54221334
96histone H2A acetylation (GO:0043968)2.54187211
97negative regulation of DNA-dependent DNA replication (GO:2000104)2.53777965
98CENP-A containing nucleosome assembly (GO:0034080)2.53160577
99dendritic spine morphogenesis (GO:0060997)2.51811241
100cranial nerve morphogenesis (GO:0021602)2.50590592
101establishment of spindle localization (GO:0051293)2.50584219
102regulation of centriole replication (GO:0046599)2.50014718
103astrocyte differentiation (GO:0048708)2.49871199
104positive regulation of cell cycle checkpoint (GO:1901978)2.48737086
105negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.48074871
106midbrain development (GO:0030901)2.47935060
107kinetochore assembly (GO:0051382)2.46821635
108ganglion development (GO:0061548)2.45712354
109ATP-dependent chromatin remodeling (GO:0043044)2.45463510
110somite rostral/caudal axis specification (GO:0032525)2.44171467
111DNA unwinding involved in DNA replication (GO:0006268)2.43944855
112embryonic foregut morphogenesis (GO:0048617)2.43696159
113cerebral cortex radially oriented cell migration (GO:0021799)2.42225030
114microtubule anchoring (GO:0034453)2.41920542
115alternative mRNA splicing, via spliceosome (GO:0000380)2.41802831
116neuron fate determination (GO:0048664)2.40672256
117regulation of histone methylation (GO:0031060)2.40496663
118positive T cell selection (GO:0043368)2.39701540
119negative regulation of DNA recombination (GO:0045910)2.38666304
120positive regulation of gene expression, epigenetic (GO:0045815)2.38469941
121left/right axis specification (GO:0070986)2.38051616
122histone exchange (GO:0043486)2.38006594
123kidney morphogenesis (GO:0060993)2.37720910
124negative regulation of transcription regulatory region DNA binding (GO:2000678)2.37209473
125cell differentiation in spinal cord (GO:0021515)2.36960872
126regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.35706176
127chromosome condensation (GO:0030261)2.35659691
128nuclear pore organization (GO:0006999)2.35469335
129cochlea morphogenesis (GO:0090103)2.35441570
130pituitary gland development (GO:0021983)2.35207573
131regulation of DNA endoreduplication (GO:0032875)2.34790694
132transmission of nerve impulse (GO:0019226)2.34587984
133eye photoreceptor cell development (GO:0042462)2.34348042
134DNA replication-independent nucleosome assembly (GO:0006336)2.34078338
135DNA replication-independent nucleosome organization (GO:0034724)2.34078338
136spinal cord association neuron differentiation (GO:0021527)2.34057956
137neuron cell-cell adhesion (GO:0007158)2.33787183
138chromatin silencing (GO:0006342)2.31948384
139photoreceptor cell development (GO:0042461)2.31896274
140microtubule polymerization or depolymerization (GO:0031109)2.31256353
141DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.31255205
142mRNA stabilization (GO:0048255)2.31036726
143RNA stabilization (GO:0043489)2.31036726
144mechanosensory behavior (GO:0007638)2.30783276
145regulation of telomere maintenance (GO:0032204)2.30180124
146regulation of oligodendrocyte differentiation (GO:0048713)2.30169776
147cerebellar Purkinje cell differentiation (GO:0021702)2.29690445
148positive regulation of neural precursor cell proliferation (GO:2000179)2.29390289
149peptidyl-lysine methylation (GO:0018022)2.29299535
150epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.28600967
151smoothened signaling pathway (GO:0007224)2.27905768
152central nervous system neuron axonogenesis (GO:0021955)2.27810635
153regulation of development, heterochronic (GO:0040034)2.27418498
154tolerance induction (GO:0002507)2.27361011
155spinal cord development (GO:0021510)2.25638548
156negative regulation of gene expression, epigenetic (GO:0045814)2.24609562
157negative regulation of mRNA metabolic process (GO:1903312)2.24070311
158neuron fate commitment (GO:0048663)2.23235126
159regulation of non-canonical Wnt signaling pathway (GO:2000050)2.23212490
160protein polyglutamylation (GO:0018095)2.22359945
161sympathetic nervous system development (GO:0048485)2.22228739
162cilium movement (GO:0003341)2.20149778
163protein localization to synapse (GO:0035418)2.19892902
164cellular response to cholesterol (GO:0071397)2.19148848
165gastrulation with mouth forming second (GO:0001702)2.18758244
166cilium assembly (GO:0042384)2.18062564
167maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.17345317
168cilium organization (GO:0044782)2.16896589
169calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.16758129

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.14941838
2E2F7_22180533_ChIP-Seq_HELA_Human5.66444388
3EZH2_22144423_ChIP-Seq_EOC_Human4.05451017
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.86365667
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.05702734
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.86817610
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.57571870
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.57180588
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.56599544
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.56303257
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.55155662
12* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.44913614
13POU5F1_16153702_ChIP-ChIP_HESCs_Human2.44162675
14IGF1R_20145208_ChIP-Seq_DFB_Human2.41321828
15GBX2_23144817_ChIP-Seq_PC3_Human2.41282260
16KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.29986523
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.27051178
18FUS_26573619_Chip-Seq_HEK293_Human2.26000173
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15194269
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15194269
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15194269
22EWS_26573619_Chip-Seq_HEK293_Human2.14109854
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07064737
24HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.05869399
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.05580901
26FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.03721500
27EGR1_19374776_ChIP-ChIP_THP-1_Human2.00155123
28TAF15_26573619_Chip-Seq_HEK293_Human1.98101890
29CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95622206
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91471095
31P300_19829295_ChIP-Seq_ESCs_Human1.88171286
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.85197484
33FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.83608952
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80239427
35* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79916553
36DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.77843763
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76753333
38SOX2_16153702_ChIP-ChIP_HESCs_Human1.76703795
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.72150341
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71927676
41EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.70522773
42VDR_22108803_ChIP-Seq_LS180_Human1.67358697
43RNF2_27304074_Chip-Seq_NSC_Mouse1.66643549
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65177616
45TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.61723526
46* KDM2B_26808549_Chip-Seq_JURKAT_Human1.59816920
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.59131644
48DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.57146576
49RING1B_27294783_Chip-Seq_NPCs_Mouse1.56107965
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.54256087
51BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53387424
52MYC_22102868_ChIP-Seq_BL_Human1.52843462
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.52624181
54* ISL1_27105846_Chip-Seq_CPCs_Mouse1.51177065
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48698226
56PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48018649
57KDM2B_26808549_Chip-Seq_DND41_Human1.45218502
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.45144445
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.42094275
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41949462
61* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.41542445
62* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.40146809
63TCF7_22412390_ChIP-Seq_EML_Mouse1.38966589
64* SMAD4_21799915_ChIP-Seq_A2780_Human1.38854936
65REST_21632747_ChIP-Seq_MESCs_Mouse1.37982325
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37307309
67CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35629976
68STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.32503497
69* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.31429955
70* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30799906
71* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30799906
72SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29287643
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.28754873
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28312228
75* PIAS1_25552417_ChIP-Seq_VCAP_Human1.27836508
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.27230571
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.25150089
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.24939554
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.24406816
80OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24245803
81RNF2_27304074_Chip-Seq_ESCs_Mouse1.23923015
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23589618
83CIITA_25753668_ChIP-Seq_RAJI_Human1.23013226
84SOX9_26525672_Chip-Seq_HEART_Mouse1.22751425
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22425840
86SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21753579
87CBP_20019798_ChIP-Seq_JUKART_Human1.21481581
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21481581
89IRF1_19129219_ChIP-ChIP_H3396_Human1.21137218
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19764341
91STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18544383
92DROSHA_22980978_ChIP-Seq_HELA_Human1.18488814
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.17699625
94* KDM2B_26808549_Chip-Seq_K562_Human1.17396744
95* TCF4_23295773_ChIP-Seq_U87_Human1.16405301
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16283435
97RUNX2_22187159_ChIP-Seq_PCA_Human1.16124616
98ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16007074
99TBX3_20139965_ChIP-Seq_MESCs_Mouse1.14277310
100* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13225398
101TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12779556
102RUNX_20019798_ChIP-Seq_JUKART_Human1.12558220
103* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.12521664
104* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11024850
105PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10687421
106TP53_16413492_ChIP-PET_HCT116_Human1.10536763
107* AR_25329375_ChIP-Seq_VCAP_Human1.10189453
108MYC_18940864_ChIP-ChIP_HL60_Human1.09898888
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09062999
110KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08508032
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08269834
112* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.08149858
113PCGF2_27294783_Chip-Seq_NPCs_Mouse1.07657001
114* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07428612
115* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07095842
116AHR_22903824_ChIP-Seq_MCF-7_Human1.06699430
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06323155
118KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.05979131
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.05962852
120ER_23166858_ChIP-Seq_MCF-7_Human1.05775455
121SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05153081
122* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.04499580
123NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03826665
124KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02772295
125* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02384993
126NANOG_16153702_ChIP-ChIP_HESCs_Human1.02199840
127AR_21572438_ChIP-Seq_LNCaP_Human1.01181689
128PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01042966
129* NANOG_18555785_Chip-Seq_ESCs_Mouse1.00965175
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99269155
131SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98833842
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98660819
133SOX2_21211035_ChIP-Seq_LN229_Gbm0.98506139
134* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98332069
135ELK1_19687146_ChIP-ChIP_HELA_Human0.98217330
136REST_18959480_ChIP-ChIP_MESCs_Mouse0.97642760
137TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.97384062
138EED_16625203_ChIP-ChIP_MESCs_Mouse0.97334479
139TBL1_22424771_ChIP-Seq_293T_Human0.97036443
140* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96528216
141RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95942139
142WDR5_24793694_ChIP-Seq_LNCAP_Human0.95906406
143* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95559568
144* RING1B_27294783_Chip-Seq_ESCs_Mouse0.94912833
145* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94704921
146LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93796535
147POU3F2_20337985_ChIP-ChIP_501MEL_Human0.93706728
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.92808514
149STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91873334
150TP63_17297297_ChIP-ChIP_HaCaT_Human0.90968486
151TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90127390
152JARID2_20064375_ChIP-Seq_MESCs_Mouse0.88270458
153EZH2_27294783_Chip-Seq_ESCs_Mouse0.87874949
154ZNF274_21170338_ChIP-Seq_K562_Hela0.87208220
155SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86942418
156STAT3_23295773_ChIP-Seq_U87_Human0.85387942
157CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85060660
158WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84374085
159CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.82823264
160UTX_26944678_Chip-Seq_JUKART_Human0.82280203
161ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81441467
162ARNT_22903824_ChIP-Seq_MCF-7_Human0.80388412
163KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80148441

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.37847974
2MP0006072_abnormal_retinal_apoptosis3.22176488
3MP0000566_synostosis2.84602173
4MP0003890_abnormal_embryonic-extraembry2.69815608
5MP0005551_abnormal_eye_electrophysiolog2.36218657
6MP0008057_abnormal_DNA_replication2.34371330
7MP0000537_abnormal_urethra_morphology2.22866062
8MP0005076_abnormal_cell_differentiation2.18913063
9* MP0005253_abnormal_eye_physiology2.16194878
10MP0003787_abnormal_imprinting2.09741859
11MP0000569_abnormal_digit_pigmentation2.05104547
12MP0003121_genomic_imprinting2.03556270
13MP0003283_abnormal_digestive_organ2.00920908
14MP0003880_abnormal_central_pattern2.00020901
15MP0003950_abnormal_plasma_membrane1.95746129
16MP0010030_abnormal_orbit_morphology1.95386040
17MP0003111_abnormal_nucleus_morphology1.84972833
18MP0004742_abnormal_vestibular_system1.82802277
19MP0001529_abnormal_vocalization1.78726985
20MP0000733_abnormal_muscle_development1.77955107
21MP0000778_abnormal_nervous_system1.77698472
22* MP0005391_vision/eye_phenotype1.76905512
23MP0003136_yellow_coat_color1.75585120
24MP0002822_catalepsy1.73247716
25MP0000383_abnormal_hair_follicle1.71780988
26MP0002234_abnormal_pharynx_morphology1.70751619
27MP0002697_abnormal_eye_size1.68492400
28MP0006292_abnormal_olfactory_placode1.68320416
29* MP0003937_abnormal_limbs/digits/tail_de1.67142941
30MP0002638_abnormal_pupillary_reflex1.66994294
31MP0008961_abnormal_basal_metabolism1.64585498
32MP0008789_abnormal_olfactory_epithelium1.63026030
33MP0003077_abnormal_cell_cycle1.59096789
34MP0001346_abnormal_lacrimal_gland1.57261643
35MP0008877_abnormal_DNA_methylation1.56528817
36MP0002009_preneoplasia1.55126914
37* MP0003861_abnormal_nervous_system1.53824533
38MP0005195_abnormal_posterior_eye1.45419175
39MP0009053_abnormal_anal_canal1.40847325
40MP0003119_abnormal_digestive_system1.39720600
41MP0002751_abnormal_autonomic_nervous1.39536187
42MP0003123_paternal_imprinting1.39091338
43MP0006276_abnormal_autonomic_nervous1.38385739
44MP0010094_abnormal_chromosome_stability1.36711892
45* MP0002233_abnormal_nose_morphology1.34853553
46MP0002092_abnormal_eye_morphology1.33856912
47* MP0001286_abnormal_eye_development1.33069278
48MP0005248_abnormal_Harderian_gland1.32474297
49MP0005423_abnormal_somatic_nervous1.32365424
50* MP0002084_abnormal_developmental_patter1.32357004
51* MP0002085_abnormal_embryonic_tissue1.32111684
52MP0003011_delayed_dark_adaptation1.31423021
53MP0001293_anophthalmia1.29531363
54MP0004270_analgesia1.28980870
55MP0002249_abnormal_larynx_morphology1.28266237
56MP0001984_abnormal_olfaction1.24778923
57MP0000467_abnormal_esophagus_morphology1.24166231
58MP0003567_abnormal_fetal_cardiomyocyte1.24153194
59MP0010678_abnormal_skin_adnexa1.24058604
60* MP0002184_abnormal_innervation1.21906471
61MP0000428_abnormal_craniofacial_morphol1.21491837
62MP0002938_white_spotting1.21262427
63MP0001486_abnormal_startle_reflex1.21236163
64* MP0003935_abnormal_craniofacial_develop1.20863101
65MP0000350_abnormal_cell_proliferation1.17187843
66* MP0000049_abnormal_middle_ear1.16727688
67* MP0002116_abnormal_craniofacial_bone1.14601174
68* MP0002557_abnormal_social/conspecific_i1.13830760
69MP0002102_abnormal_ear_morphology1.12231135
70MP0004197_abnormal_fetal_growth/weight/1.11012508
71MP0004133_heterotaxia1.10334045
72MP0000462_abnormal_digestive_system1.07274532
73MP0001188_hyperpigmentation1.07264572
74* MP0002752_abnormal_somatic_nervous1.07256912
75MP0001672_abnormal_embryogenesis/_devel1.07020462
76MP0005380_embryogenesis_phenotype1.07020462
77MP0005377_hearing/vestibular/ear_phenot1.06314932
78MP0003878_abnormal_ear_physiology1.06314932
79MP0003693_abnormal_embryo_hatching1.04529521
80* MP0003755_abnormal_palate_morphology1.03794344
81MP0002277_abnormal_respiratory_mucosa1.03718116
82MP0002734_abnormal_mechanical_nocicepti1.03442204
83* MP0000432_abnormal_head_morphology1.02043843
84MP0005394_taste/olfaction_phenotype1.01598794
85MP0005499_abnormal_olfactory_system1.01598794
86MP0009703_decreased_birth_body1.01128455
87MP0003315_abnormal_perineum_morphology1.00979127
88MP0002736_abnormal_nociception_after1.00424315
89MP0002088_abnormal_embryonic_growth/wei1.00099807
90MP0003984_embryonic_growth_retardation0.99051365
91MP0004811_abnormal_neuron_physiology0.98540124
92MP0001730_embryonic_growth_arrest0.98265888
93MP0009278_abnormal_bone_marrow0.97535056
94MP0000955_abnormal_spinal_cord0.97412313
95* MP0003938_abnormal_ear_development0.97155142
96MP0005187_abnormal_penis_morphology0.96709188
97MP0002932_abnormal_joint_morphology0.96556926
98MP0002098_abnormal_vibrissa_morphology0.96163136
99MP0008007_abnormal_cellular_replicative0.95743959
100* MP0000631_abnormal_neuroendocrine_gland0.94938492
101MP0002735_abnormal_chemical_nociception0.94376866
102MP0003763_abnormal_thymus_physiology0.93252392
103MP0004859_abnormal_synaptic_plasticity0.92890756
104MP0009046_muscle_twitch0.92827523
105MP0001485_abnormal_pinna_reflex0.91701022
106MP0004145_abnormal_muscle_electrophysio0.91639451
107MP0008058_abnormal_DNA_repair0.91513633
108MP0001697_abnormal_embryo_size0.91445979
109MP0003635_abnormal_synaptic_transmissio0.91406279
110MP0001324_abnormal_eye_pigmentation0.91183148
111MP0002063_abnormal_learning/memory/cond0.91156291
112MP0004142_abnormal_muscle_tone0.91015996
113MP0003385_abnormal_body_wall0.90683884
114MP0002572_abnormal_emotion/affect_behav0.89752796
115* MP0002152_abnormal_brain_morphology0.88878654
116MP0004957_abnormal_blastocyst_morpholog0.87694371
117MP0000678_abnormal_parathyroid_gland0.86074095
118MP0000647_abnormal_sebaceous_gland0.85653752
119MP0009745_abnormal_behavioral_response0.85600745
120MP0010307_abnormal_tumor_latency0.85073948
121* MP0002882_abnormal_neuron_morphology0.84117507
122* MP0002067_abnormal_sensory_capabilities0.84069650
123* MP0001299_abnormal_eye_distance/0.84036237
124MP0002282_abnormal_trachea_morphology0.82985170
125MP0002111_abnormal_tail_morphology0.82465498
126MP0001968_abnormal_touch/_nociception0.82392899
127MP0003941_abnormal_skin_development0.82201965
128MP0005645_abnormal_hypothalamus_physiol0.82165296
129* MP0000026_abnormal_inner_ear0.82149277
130MP0009672_abnormal_birth_weight0.81796941
131* MP0002081_perinatal_lethality0.81078482
132MP0004885_abnormal_endolymph0.80694246
133MP0008995_early_reproductive_senescence0.80307809
134MP0003122_maternal_imprinting0.80060451

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.32922370
2Congenital stationary night blindness (HP:0007642)4.12198262
3Bony spicule pigmentary retinopathy (HP:0007737)3.52564121
4Hepatoblastoma (HP:0002884)3.49535182
5Abnormality of the labia minora (HP:0012880)3.31047112
6Lip pit (HP:0100267)3.25769591
7Dyschromatopsia (HP:0007641)3.12265597
8Pendular nystagmus (HP:0012043)3.08935884
9Volvulus (HP:0002580)3.06079581
10Absent rod-and cone-mediated responses on ERG (HP:0007688)2.84641397
11Ectopic kidney (HP:0000086)2.76079724
12Abnormal rod and cone electroretinograms (HP:0008323)2.75409044
13Chorioretinal atrophy (HP:0000533)2.71495728
14Pancreatic fibrosis (HP:0100732)2.67294089
15Colon cancer (HP:0003003)2.65002858
16Abnormal number of incisors (HP:0011064)2.59628658
17Nephronophthisis (HP:0000090)2.55865413
18Pancreatic cysts (HP:0001737)2.54882649
19Skull defect (HP:0001362)2.52336972
20Optic nerve hypoplasia (HP:0000609)2.51648809
21Chronic hepatic failure (HP:0100626)2.50704047
22True hermaphroditism (HP:0010459)2.44775526
23Abnormality of chromosome segregation (HP:0002916)2.42774093
24Uterine leiomyosarcoma (HP:0002891)2.39573311
25Leiomyosarcoma (HP:0100243)2.39573311
26Abnormality of midbrain morphology (HP:0002418)2.35082132
27Molar tooth sign on MRI (HP:0002419)2.35082132
28Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35014197
29Abnormality of the axillary hair (HP:0100134)2.34576501
30Abnormality of secondary sexual hair (HP:0009888)2.34576501
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.33935187
32Short 4th metacarpal (HP:0010044)2.33935187
33Aplasia/Hypoplasia of the sternum (HP:0006714)2.31085523
34Midline defect of the nose (HP:0004122)2.30224885
35Macroorchidism (HP:0000053)2.29773215
36Pigmentary retinal degeneration (HP:0001146)2.28175323
37Septo-optic dysplasia (HP:0100842)2.27477573
38Long eyelashes (HP:0000527)2.26999479
39Truncal obesity (HP:0001956)2.26242065
40Abnormality of the renal medulla (HP:0100957)2.26002448
41Trigonocephaly (HP:0000243)2.25273386
42Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.24303590
43Cortical dysplasia (HP:0002539)2.23655810
44Transitional cell carcinoma of the bladder (HP:0006740)2.22265133
45Abnormality of the nasal septum (HP:0000419)2.21916978
46Type II diabetes mellitus (HP:0005978)2.21541252
47Decreased central vision (HP:0007663)2.19062191
48* Anal stenosis (HP:0002025)2.18446866
49Bilateral microphthalmos (HP:0007633)2.17195592
50Chromsome breakage (HP:0040012)2.14496460
51Increased nuchal translucency (HP:0010880)2.13806686
52Bifid tongue (HP:0010297)2.13164616
53Drooling (HP:0002307)2.12144370
54Rib fusion (HP:0000902)2.11109132
55Central scotoma (HP:0000603)2.11070100
56Oligodontia (HP:0000677)2.08860121
57Abnormality of macular pigmentation (HP:0008002)2.08764675
58Cutaneous finger syndactyly (HP:0010554)2.08463487
59Attenuation of retinal blood vessels (HP:0007843)2.08254140
60Genital tract atresia (HP:0001827)2.07329037
61Depressed nasal tip (HP:0000437)2.06313807
62Abnormality of the aortic arch (HP:0012303)2.06084170
63Meckel diverticulum (HP:0002245)2.05832580
64Supernumerary ribs (HP:0005815)2.04921784
65Postaxial foot polydactyly (HP:0001830)2.04487214
66Abnormality of the ileum (HP:0001549)2.04255635
67Vaginal atresia (HP:0000148)2.04176202
68* Preaxial hand polydactyly (HP:0001177)2.03146064
69Abnormality of abdominal situs (HP:0011620)2.02271048
70Abdominal situs inversus (HP:0003363)2.02271048
71Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.00682825
72Abnormal lung lobation (HP:0002101)2.00669367
73Cone-rod dystrophy (HP:0000548)2.00518781
74Abolished electroretinogram (ERG) (HP:0000550)2.00204373
75Hypoplastic labia majora (HP:0000059)2.00158300
76Abnormality of the septum pellucidum (HP:0007375)2.00057041
77Optic nerve coloboma (HP:0000588)1.99439784
78Hyperventilation (HP:0002883)1.99025267
79Absent septum pellucidum (HP:0001331)1.98862459
80Medial flaring of the eyebrow (HP:0010747)1.97027770
81* Renal hypoplasia (HP:0000089)1.96722181
82Tubulointerstitial nephritis (HP:0001970)1.95521612
83Abnormality of chromosome stability (HP:0003220)1.95444315
84Patellar aplasia (HP:0006443)1.94718506
85Cystic liver disease (HP:0006706)1.94529746
86Gait imbalance (HP:0002141)1.93916290
87Hyperacusis (HP:0010780)1.93132946
88Bladder carcinoma (HP:0002862)1.93055262
89Bladder neoplasm (HP:0009725)1.93055262
90Heterotopia (HP:0002282)1.92886212
91Genetic anticipation (HP:0003743)1.92786534
92Scotoma (HP:0000575)1.92779109
93Postaxial hand polydactyly (HP:0001162)1.92039544
94Gastrointestinal carcinoma (HP:0002672)1.91964117
95Malignant gastrointestinal tract tumors (HP:0006749)1.91964117
96* Intestinal atresia (HP:0011100)1.91891328
97Alacrima (HP:0000522)1.91130596
98Elfin facies (HP:0004428)1.91010709
99Urethral obstruction (HP:0000796)1.90934212
100Poor coordination (HP:0002370)1.87818439
101Decreased lacrimation (HP:0000633)1.87705257
102Broad-based gait (HP:0002136)1.87351865
103High anterior hairline (HP:0009890)1.87044639
104Papillary thyroid carcinoma (HP:0002895)1.86957925
105Excessive salivation (HP:0003781)1.86501426
106Renal duplication (HP:0000075)1.86375306
107Supernumerary spleens (HP:0009799)1.86162432
108Hypoplastic pelvis (HP:0008839)1.85565618
109Renovascular hypertension (HP:0100817)1.85539321
110Preauricular pit (HP:0004467)1.85348123
111Periauricular skin pits (HP:0100277)1.85348123
112Cutaneous syndactyly (HP:0012725)1.85182714
113Facial hemangioma (HP:0000329)1.84317422
114Abnormality of the labia majora (HP:0012881)1.84063059
115Congenital primary aphakia (HP:0007707)1.83979471
116Prominent nose (HP:0000448)1.82913659
117Supernumerary bones of the axial skeleton (HP:0009144)1.82830533
118Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.82780146
119Neoplasm of the adrenal cortex (HP:0100641)1.80578212
120Sclerocornea (HP:0000647)1.80428413
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.80291139
122Proximal placement of thumb (HP:0009623)1.79262641
123* Dandy-Walker malformation (HP:0001305)1.79233529
124* Oligodactyly (hands) (HP:0001180)1.78310159
125Overriding aorta (HP:0002623)1.76979805
126Limited elbow extension (HP:0001377)1.76968102
127Narrow forehead (HP:0000341)1.76349302
128Macular degeneration (HP:0000608)1.75743438
129Tented upper lip vermilion (HP:0010804)1.75449696
130Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.75395396
131Short 1st metacarpal (HP:0010034)1.75395396
132Sloping forehead (HP:0000340)1.74782594
133Abnormality of the metopic suture (HP:0005556)1.74170297
134Aplasia/Hypoplasia of the patella (HP:0006498)1.73590334
135Skin pits (HP:0100276)1.73335583
136Spina bifida occulta (HP:0003298)1.72351140
137Photophobia (HP:0000613)1.72256475
138Abnormality of the 4th metacarpal (HP:0010012)1.71588029
139Partial agenesis of the corpus callosum (HP:0001338)1.70902510
140Nephroblastoma (Wilms tumor) (HP:0002667)1.70681727
141Progressive cerebellar ataxia (HP:0002073)1.70110470
142Vitreoretinal degeneration (HP:0000655)1.69428148
143Aplasia cutis congenita (HP:0001057)1.69381086
144Neoplasm of the oral cavity (HP:0100649)1.69340399
145Median cleft lip (HP:0000161)1.69239039
146Duplicated collecting system (HP:0000081)1.68675947
147* Micropenis (HP:0000054)1.68332834
148* Vesicoureteral reflux (HP:0000076)1.67840945
149Maternal diabetes (HP:0009800)1.67778130
150Abnormality of the intervertebral disk (HP:0005108)1.67376911
151Abnormality of the pubic bones (HP:0003172)1.67152166
152Broad thumb (HP:0011304)1.67031943
153Severe visual impairment (HP:0001141)1.66815667
154Abnormality of the diencephalon (HP:0010662)1.66246877
155Abnormality of the ischium (HP:0003174)1.65745169
156Abnormality of the incisor (HP:0000676)1.65523853
157Abnormality of the renal collecting system (HP:0004742)1.64433204
158Abnormal hair whorl (HP:0010721)1.64139450
159Aplasia/Hypoplasia of the nipples (HP:0006709)1.63703265
160Rhabdomyosarcoma (HP:0002859)1.63681871
161Vertebral arch anomaly (HP:0008438)1.63518878
162Preaxial foot polydactyly (HP:0001841)1.63383393
163Medulloblastoma (HP:0002885)1.63345930
164Nephrogenic diabetes insipidus (HP:0009806)1.63310182
165Abnormality of the carotid arteries (HP:0005344)1.62526794
166Deviation of the thumb (HP:0009603)1.62513905
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.62141465
168Short phalanx of the thumb (HP:0009660)1.62119898
169* Anophthalmia (HP:0000528)1.61976636
170Narrow palate (HP:0000189)1.61929254
171Impulsivity (HP:0100710)1.61275385
172Embryonal renal neoplasm (HP:0011794)1.60914561
173Neoplasm of striated muscle (HP:0009728)1.60649348
174Keratoconus (HP:0000563)1.60318582
175Increased corneal curvature (HP:0100692)1.60318582

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.39700526
2CDK123.27728646
3CDC72.78880596
4TNIK2.69795094
5CAMK1G2.57669647
6LATS12.54409481
7WNK32.49789053
8MAP3K102.47789605
9ICK2.41603844
10BRD42.35000776
11MAP3K42.25641351
12CAMK1D2.22075638
13FRK2.12710348
14BMPR1B1.95866797
15BCR1.89967735
16EPHB21.88893983
17NEK21.87819968
18MKNK21.86958494
19TRIM281.75465360
20TLK11.73784791
21SRPK11.73700150
22PASK1.66541181
23MELK1.61502182
24MAP4K21.61161399
25MKNK11.60789101
26EPHA41.58861273
27PNCK1.58821795
28KSR11.56168213
29CDK91.51189969
30PKN11.49780684
31UHMK11.48258735
32ERBB21.41807042
33WEE11.41155383
34MAPK131.38033704
35NUAK11.37256951
36HIPK21.35695598
37DMPK1.33137619
38ITK1.29785042
39TYRO31.27014157
40INSRR1.26143725
41CDK191.24916999
42DYRK1B1.21459611
43BRSK21.20315967
44FGFR21.19622417
45ACVR1B1.18769772
46MAP2K71.16802940
47PLK21.13266928
48CHUK1.12659478
49GRK11.11609375
50NTRK21.10571858
51CDK31.09609022
52MAP4K11.06567292
53BUB11.06429386
54CLK11.05942735
55STK38L1.05844774
56CHEK21.04086449
57CDC42BPA1.02429476
58NLK1.02108733
59RPS6KA51.01767526
60IRAK21.01642627
61DYRK31.01387966
62TSSK61.00102628
63WNK11.00049155
64STK100.98382415
65PTK60.98156915
66EPHB10.97914300
67ATR0.97687841
68MTOR0.94997219
69CSNK1G20.91479750
70TTK0.90099313
71SIK20.90035385
72ATM0.89896122
73STK390.89094737
74YES10.88116683
75ALK0.87353140
76MAPK150.86832912
77* CHEK10.86700243
78PDGFRB0.85878159
79NTRK30.84199518
80CSNK1D0.82067257
81CSNK1A1L0.81475043
82CDK70.79487296
83AURKB0.79417777
84CDK60.78912020
85CDK10.78242877
86EPHA30.77755053
87TAF10.76819090
88WNK40.76640759
89FGFR30.76374621
90TXK0.76252347
91STK30.73645536
92PRKCG0.73188086
93VRK10.72690816
94STK40.71673291
95* CDK20.69478907
96OXSR10.67830416
97DYRK20.67539555
98STK110.66701806
99PAK30.66470318
100FGFR40.66419466
101SGK4940.65900201
102SGK2230.65900201
103PDGFRA0.65090152
104CSNK1E0.63318431
105CDK40.62462975
106GSK3A0.60818243
107NEK60.60647803
108STK160.59119838
109ZAK0.58994007
110MAPK140.58592403
111MINK10.57745364
112TGFBR10.57261632
113BRSK10.56996256
114FGFR10.56000492
115RPS6KA40.55509217
116AKT10.55165620
117EEF2K0.54661609
118IRAK10.54260849
119ERBB30.53798035
120PRKDC0.53649610
121CAMK40.53516147
122GSK3B0.53337171
123MARK30.51871692
124CSNK1G10.51565104
125NME10.50538420
126SGK20.49444970
127SIK10.49318907
128AKT30.48984968
129DYRK1A0.48239977
130PLK30.46026451
131PLK10.45953060
132ROCK20.45556586
133MAPK100.44763910
134PRKAA10.44029989
135ADRBK20.43292391
136MAPK90.42974815
137PLK40.41170682
138SGK10.40645022
139CSNK1G30.40615317
140MARK10.40558037
141PIM10.40351415

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.08429227
2Notch signaling pathway_Homo sapiens_hsa043302.66933482
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.26635479
4Nicotine addiction_Homo sapiens_hsa050332.23587771
5Lysine degradation_Homo sapiens_hsa003102.16760881
6mRNA surveillance pathway_Homo sapiens_hsa030152.01757530
7Basal cell carcinoma_Homo sapiens_hsa052171.98506995
8MicroRNAs in cancer_Homo sapiens_hsa052061.93259451
9Steroid biosynthesis_Homo sapiens_hsa001001.77773786
10Cell cycle_Homo sapiens_hsa041101.76752246
11Systemic lupus erythematosus_Homo sapiens_hsa053221.75270384
12Spliceosome_Homo sapiens_hsa030401.71571441
13Transcriptional misregulation in cancer_Homo sapiens_hsa052021.64512370
14RNA polymerase_Homo sapiens_hsa030201.58052461
15Fanconi anemia pathway_Homo sapiens_hsa034601.57497692
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.55409333
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53202554
18Hedgehog signaling pathway_Homo sapiens_hsa043401.51866952
19T cell receptor signaling pathway_Homo sapiens_hsa046601.49342101
20Propanoate metabolism_Homo sapiens_hsa006401.47113487
21Renal cell carcinoma_Homo sapiens_hsa052111.44289156
22Chronic myeloid leukemia_Homo sapiens_hsa052201.43068006
23Protein export_Homo sapiens_hsa030601.42839092
24Axon guidance_Homo sapiens_hsa043601.40050101
25Type II diabetes mellitus_Homo sapiens_hsa049301.35619524
26Hippo signaling pathway_Homo sapiens_hsa043901.33439568
27Butanoate metabolism_Homo sapiens_hsa006501.29480230
28Taste transduction_Homo sapiens_hsa047421.24716807
29Viral myocarditis_Homo sapiens_hsa054161.24440605
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.21229042
31Colorectal cancer_Homo sapiens_hsa052101.19785147
32Nucleotide excision repair_Homo sapiens_hsa034201.19000869
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.17430789
34HTLV-I infection_Homo sapiens_hsa051661.16108831
35Homologous recombination_Homo sapiens_hsa034401.16056736
36Oocyte meiosis_Homo sapiens_hsa041141.14861015
37Alcoholism_Homo sapiens_hsa050341.12651121
38Wnt signaling pathway_Homo sapiens_hsa043101.12616685
39Adherens junction_Homo sapiens_hsa045201.12407602
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.12263727
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12067644
42Prostate cancer_Homo sapiens_hsa052151.10189151
43Dorso-ventral axis formation_Homo sapiens_hsa043201.09973395
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09681988
45NF-kappa B signaling pathway_Homo sapiens_hsa040641.08581606
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08134896
47Pancreatic cancer_Homo sapiens_hsa052121.06609631
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02767098
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01576948
50TGF-beta signaling pathway_Homo sapiens_hsa043501.01378023
51Viral carcinogenesis_Homo sapiens_hsa052031.01115743
52Thyroid hormone signaling pathway_Homo sapiens_hsa049191.00612608
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98247595
54Selenocompound metabolism_Homo sapiens_hsa004500.97936011
55Circadian rhythm_Homo sapiens_hsa047100.96943173
56mTOR signaling pathway_Homo sapiens_hsa041500.95691400
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93396212
58Morphine addiction_Homo sapiens_hsa050320.92809501
59B cell receptor signaling pathway_Homo sapiens_hsa046620.92519640
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91596449
61Tight junction_Homo sapiens_hsa045300.91181519
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.91002970
63Endometrial cancer_Homo sapiens_hsa052130.90810828
64Autoimmune thyroid disease_Homo sapiens_hsa053200.90210336
65Herpes simplex infection_Homo sapiens_hsa051680.89842083
66ErbB signaling pathway_Homo sapiens_hsa040120.89559252
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.88948463
68Small cell lung cancer_Homo sapiens_hsa052220.88688016
69GABAergic synapse_Homo sapiens_hsa047270.88547856
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87144389
71Primary immunodeficiency_Homo sapiens_hsa053400.86668986
72RNA degradation_Homo sapiens_hsa030180.86341248
73Dopaminergic synapse_Homo sapiens_hsa047280.85958377
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83747124
75Circadian entrainment_Homo sapiens_hsa047130.83113706
76Mismatch repair_Homo sapiens_hsa034300.82925091
77MAPK signaling pathway_Homo sapiens_hsa040100.82651034
78FoxO signaling pathway_Homo sapiens_hsa040680.82521006
79Pathways in cancer_Homo sapiens_hsa052000.82057052
80Osteoclast differentiation_Homo sapiens_hsa043800.81525844
81Chemokine signaling pathway_Homo sapiens_hsa040620.81446052
82RNA transport_Homo sapiens_hsa030130.81130845
83Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78688785
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78098675
85Proteoglycans in cancer_Homo sapiens_hsa052050.78064437
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77863665
87Hepatitis B_Homo sapiens_hsa051610.77022608
88Jak-STAT signaling pathway_Homo sapiens_hsa046300.76734722
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76707869
90Non-small cell lung cancer_Homo sapiens_hsa052230.76625325
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.76046631
92Choline metabolism in cancer_Homo sapiens_hsa052310.75285408
93Insulin secretion_Homo sapiens_hsa049110.74690414
94Prolactin signaling pathway_Homo sapiens_hsa049170.73858338
95Leukocyte transendothelial migration_Homo sapiens_hsa046700.73389396
96Vitamin B6 metabolism_Homo sapiens_hsa007500.73278263
97Measles_Homo sapiens_hsa051620.70936597
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70801339
99Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70202931
100Basal transcription factors_Homo sapiens_hsa030220.70018409
101Cholinergic synapse_Homo sapiens_hsa047250.69802710
102Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67002471
103Nitrogen metabolism_Homo sapiens_hsa009100.66602240
104Cocaine addiction_Homo sapiens_hsa050300.66335830
105Graft-versus-host disease_Homo sapiens_hsa053320.66190033
106Serotonergic synapse_Homo sapiens_hsa047260.64736046
107Epstein-Barr virus infection_Homo sapiens_hsa051690.64658281
108DNA replication_Homo sapiens_hsa030300.64509564
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63993913
110Non-homologous end-joining_Homo sapiens_hsa034500.63821543
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.63353467
112Purine metabolism_Homo sapiens_hsa002300.62951492
113Huntingtons disease_Homo sapiens_hsa050160.62752084
114p53 signaling pathway_Homo sapiens_hsa041150.62233990
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.61817790
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.61425463
117Glutamatergic synapse_Homo sapiens_hsa047240.60589442
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.59913184
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59330863
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.59141025
121Allograft rejection_Homo sapiens_hsa053300.58157554
122One carbon pool by folate_Homo sapiens_hsa006700.57830759
123Insulin resistance_Homo sapiens_hsa049310.57327995
124Base excision repair_Homo sapiens_hsa034100.55480625
125Ether lipid metabolism_Homo sapiens_hsa005650.55449597
126Olfactory transduction_Homo sapiens_hsa047400.54657455
127Glioma_Homo sapiens_hsa052140.53894527
128NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52056554
129Inositol phosphate metabolism_Homo sapiens_hsa005620.52043239
130Acute myeloid leukemia_Homo sapiens_hsa052210.52003096
131cAMP signaling pathway_Homo sapiens_hsa040240.51904379
132VEGF signaling pathway_Homo sapiens_hsa043700.51255642
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51038712
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50790529
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49828299
136Rap1 signaling pathway_Homo sapiens_hsa040150.49527230
137Melanogenesis_Homo sapiens_hsa049160.48876945
138Estrogen signaling pathway_Homo sapiens_hsa049150.48872528
139Long-term depression_Homo sapiens_hsa047300.48677384
140Linoleic acid metabolism_Homo sapiens_hsa005910.48377701
141Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47781657
142Apoptosis_Homo sapiens_hsa042100.46754872
143Pyrimidine metabolism_Homo sapiens_hsa002400.40522512
144Cardiac muscle contraction_Homo sapiens_hsa042600.39918466
145Regulation of autophagy_Homo sapiens_hsa041400.38874201
146Gap junction_Homo sapiens_hsa045400.36826432
147Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35807096
148Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34574904
149Amphetamine addiction_Homo sapiens_hsa050310.33307632
150Fatty acid metabolism_Homo sapiens_hsa012120.29776309

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