CHCHD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an inner mitochondrial membrane scaffold protein. Absence of the encoded protein affects the structural integrity of mitochondrial cristae and leads to reductions in ATP production, cell growth, and oxygen consumption. This protein is part of the mitochondrial contact site and cristae organizing system (MICOS). Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.81991537
2translational termination (GO:0006415)7.58246277
3tricarboxylic acid cycle (GO:0006099)6.98482812
4ribosomal small subunit assembly (GO:0000028)6.78842364
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.73310772
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.65538993
7cotranslational protein targeting to membrane (GO:0006613)6.58544842
8protein targeting to ER (GO:0045047)6.47810824
9translational elongation (GO:0006414)6.27770005
10energy coupled proton transport, down electrochemical gradient (GO:0015985)6.24946280
11ATP synthesis coupled proton transport (GO:0015986)6.24946280
12establishment of protein localization to endoplasmic reticulum (GO:0072599)6.23751053
13oxidative phosphorylation (GO:0006119)6.05595318
14protein localization to endoplasmic reticulum (GO:0070972)6.03860428
15cellular protein complex disassembly (GO:0043624)5.97898475
16maturation of SSU-rRNA (GO:0030490)5.96105429
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.88272021
18viral life cycle (GO:0019058)5.73040418
19respiratory electron transport chain (GO:0022904)5.72545415
20ribosomal small subunit biogenesis (GO:0042274)5.68824235
21electron transport chain (GO:0022900)5.57176244
22translational initiation (GO:0006413)5.55996359
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.54230386
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.30131119
25establishment of protein localization to mitochondrial membrane (GO:0090151)5.26736476
26protein complex disassembly (GO:0043241)5.19386447
27ribosomal large subunit biogenesis (GO:0042273)5.18655229
28lysine metabolic process (GO:0006553)5.13824253
29lysine catabolic process (GO:0006554)5.13824253
30sarcomere organization (GO:0045214)5.07838320
31macromolecular complex disassembly (GO:0032984)4.93126273
32fatty acid beta-oxidation (GO:0006635)4.87493402
33regulation of acyl-CoA biosynthetic process (GO:0050812)4.78790562
34actin-myosin filament sliding (GO:0033275)4.72299840
35muscle filament sliding (GO:0030049)4.72299840
36NADH metabolic process (GO:0006734)4.69061533
37carnitine shuttle (GO:0006853)4.60979060
38aspartate family amino acid catabolic process (GO:0009068)4.55081687
39branched-chain amino acid catabolic process (GO:0009083)4.50638266
40regulation of cofactor metabolic process (GO:0051193)4.49705116
41regulation of coenzyme metabolic process (GO:0051196)4.49705116
42regulation of sequestering of triglyceride (GO:0010889)4.44316561
432-oxoglutarate metabolic process (GO:0006103)4.41622944
44sequestering of actin monomers (GO:0042989)4.40070339
45protein targeting to membrane (GO:0006612)4.39371962
46fatty acid transmembrane transport (GO:1902001)4.35421780
47nuclear-transcribed mRNA catabolic process (GO:0000956)4.26648007
48translation (GO:0006412)4.24281674
49fatty acid catabolic process (GO:0009062)4.20242778
50succinate metabolic process (GO:0006105)4.19361660
51fatty acid oxidation (GO:0019395)4.19269164
52cardiac myofibril assembly (GO:0055003)4.17835125
53cellular ketone body metabolic process (GO:0046950)4.16504758
54lipid oxidation (GO:0034440)4.10621638
55mRNA catabolic process (GO:0006402)4.06912452
56branched-chain amino acid metabolic process (GO:0009081)4.03779330
57valine metabolic process (GO:0006573)3.99575369
58acetyl-CoA metabolic process (GO:0006084)3.98617188
59myofibril assembly (GO:0030239)3.95769082
60ATP biosynthetic process (GO:0006754)3.93170670
61oxaloacetate metabolic process (GO:0006107)3.91485727
62negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.89653287
63tricarboxylic acid metabolic process (GO:0072350)3.89239057
64establishment of integrated proviral latency (GO:0075713)3.87218529
65glyoxylate metabolic process (GO:0046487)3.86187327
66short-chain fatty acid metabolic process (GO:0046459)3.84764099
67chaperone-mediated protein transport (GO:0072321)3.81520479
68chromatin remodeling at centromere (GO:0031055)3.81265451
69actin-mediated cell contraction (GO:0070252)3.81102570
70heart contraction (GO:0060047)3.80755237
71heart process (GO:0003015)3.80755237
72CENP-A containing nucleosome assembly (GO:0034080)3.78967170
73ubiquinone biosynthetic process (GO:0006744)3.78707754
74quinone biosynthetic process (GO:1901663)3.78707754
75ketone body metabolic process (GO:1902224)3.76869889
76regulation of skeletal muscle contraction (GO:0014819)3.74993727
77RNA catabolic process (GO:0006401)3.71826072
78proteasome assembly (GO:0043248)3.67819041
79aerobic respiration (GO:0009060)3.65032081
80carnitine transmembrane transport (GO:1902603)3.62744173
81cardiac muscle cell development (GO:0055013)3.62591946
82regulation of fatty acid oxidation (GO:0046320)3.56782056
83monocarboxylic acid catabolic process (GO:0072329)3.56105027
84regulation of sulfur metabolic process (GO:0042762)3.55727163
85amino-acid betaine transport (GO:0015838)3.53976742
86carnitine transport (GO:0015879)3.53976742
87cardiac muscle contraction (GO:0060048)3.52428333
88ubiquinone metabolic process (GO:0006743)3.40120297
89carnitine metabolic process (GO:0009437)3.39809702
90negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.37718278
91negative regulation of potassium ion transmembrane transport (GO:1901380)3.35960486
92cardiac cell development (GO:0055006)3.35630503
93ribonucleoprotein complex biogenesis (GO:0022613)3.35615376
94purine nucleoside triphosphate biosynthetic process (GO:0009145)3.35244037
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.34730561
96L-phenylalanine metabolic process (GO:0006558)3.34730561
97creatine metabolic process (GO:0006600)3.33882152
98purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30990919
99spliceosomal snRNP assembly (GO:0000387)3.29461941
100DNA strand elongation involved in DNA replication (GO:0006271)3.26885872
101cellular respiration (GO:0045333)3.26639374
102DNA damage response, detection of DNA damage (GO:0042769)3.24995712
103biotin metabolic process (GO:0006768)3.24546433
104bundle of His cell to Purkinje myocyte communication (GO:0086069)3.22937569
105cardiac muscle tissue morphogenesis (GO:0055008)3.22890973
106positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.22797007
107mitochondrial respiratory chain complex I assembly (GO:0032981)3.21430850
108NADH dehydrogenase complex assembly (GO:0010257)3.21430850
109mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21430850
110cellular component biogenesis (GO:0044085)3.20644257
111regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.19599444
112fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.19419689
113purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.18937834
114purine nucleoside monophosphate biosynthetic process (GO:0009127)3.18937834
115protein neddylation (GO:0045116)3.17487025
116regulation of relaxation of muscle (GO:1901077)3.14951925
117formation of translation preinitiation complex (GO:0001731)3.14179546
118regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.14090037
119regulation of mitochondrial translation (GO:0070129)3.13819018
120DNA strand elongation (GO:0022616)3.13724551
121amino-acid betaine metabolic process (GO:0006577)3.12887242
122L-phenylalanine catabolic process (GO:0006559)3.12570378
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.12570378
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12556824
125negative regulation of fatty acid biosynthetic process (GO:0045717)3.10160510
126DNA replication checkpoint (GO:0000076)3.09950303
127histone exchange (GO:0043486)3.06939518
128DNA ligation (GO:0006266)3.06637514
129ribonucleoside triphosphate biosynthetic process (GO:0009201)3.06335438
130telomere maintenance via semi-conservative replication (GO:0032201)3.05077805
131negative regulation of ligase activity (GO:0051352)3.04964536
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04964536
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03886465
134acyl-CoA metabolic process (GO:0006637)3.00383316
135thioester metabolic process (GO:0035383)3.00383316
136positive regulation of fatty acid oxidation (GO:0046321)3.00309042
137establishment of protein localization to membrane (GO:0090150)2.99647153
138actomyosin structure organization (GO:0031032)2.99448211
139heart trabecula formation (GO:0060347)2.98938315
140microtubule depolymerization (GO:0007019)2.98009813
141regulation of actin filament-based movement (GO:1903115)2.96311359
142protein localization to kinetochore (GO:0034501)2.95275006
143ethanol oxidation (GO:0006069)2.94971647
144transcription elongation from RNA polymerase III promoter (GO:0006385)2.94539940
145termination of RNA polymerase III transcription (GO:0006386)2.94539940
146DNA replication-independent nucleosome organization (GO:0034724)2.94111088
147DNA replication-independent nucleosome assembly (GO:0006336)2.94111088
148quaternary ammonium group transport (GO:0015697)2.93992912
149muscle tissue morphogenesis (GO:0060415)2.93554439
150purine nucleobase biosynthetic process (GO:0009113)2.92607102
151striated muscle contraction (GO:0006941)2.92028677
152thioester biosynthetic process (GO:0035384)2.91561776
153acyl-CoA biosynthetic process (GO:0071616)2.91561776
154ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.91506518
155protein complex biogenesis (GO:0070271)2.89819845
156regulation of triglyceride catabolic process (GO:0010896)2.89537628
157mitochondrial respiratory chain complex assembly (GO:0033108)2.89326624
158nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.88926342
159establishment of viral latency (GO:0019043)2.88735983
160rRNA modification (GO:0000154)2.88314663
161establishment of protein localization to organelle (GO:0072594)2.86533929
162protein targeting (GO:0006605)2.85716915
163IMP biosynthetic process (GO:0006188)2.82394163
164mitotic sister chromatid segregation (GO:0000070)2.82123534
165hydrogen ion transmembrane transport (GO:1902600)2.81575060
166midbrain development (GO:0030901)2.81510818
167rRNA processing (GO:0006364)2.81363439
168signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.75062985
169signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.75062985
170signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.75062985
171exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.74571564
172* inner mitochondrial membrane organization (GO:0007007)2.74234203
173DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.73865049
174intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71021780
175signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71021780
176nucleoside triphosphate biosynthetic process (GO:0009142)2.70509798
177IMP metabolic process (GO:0046040)2.69684875
178rRNA metabolic process (GO:0016072)2.69427282
179spliceosomal complex assembly (GO:0000245)2.66250966
180signal transduction involved in DNA damage checkpoint (GO:0072422)2.65701941
181signal transduction involved in DNA integrity checkpoint (GO:0072401)2.65701941
1827-methylguanosine mRNA capping (GO:0006370)2.63708416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.08650848
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.34648285
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.88791346
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.87648734
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.30949308
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26692767
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.25975364
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.21708747
9* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.06169545
10MYC_18555785_ChIP-Seq_MESCs_Mouse3.02634267
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92264349
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.72740324
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.66736611
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.64725725
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49646274
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.42543634
17* GABP_17652178_ChIP-ChIP_JURKAT_Human2.41147694
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.35171080
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.32303061
20* ETS1_20019798_ChIP-Seq_JURKAT_Human2.32092175
21EGR1_23403033_ChIP-Seq_LIVER_Mouse2.31033302
22RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29679347
23HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.21986763
24* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21587990
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.17795372
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.16599097
27E2F7_22180533_ChIP-Seq_HELA_Human2.07263845
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02633165
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.99979084
30CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95125432
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92065589
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88107036
33* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87103943
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86878547
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83415326
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.79808028
37* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.78110037
38MYC_18940864_ChIP-ChIP_HL60_Human1.76404995
39DCP1A_22483619_ChIP-Seq_HELA_Human1.74975154
40CLOCK_20551151_ChIP-Seq_293T_Human1.69248914
41PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.68183353
42ZNF263_19887448_ChIP-Seq_K562_Human1.66755509
43BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.66304825
44STAT3_1855785_ChIP-Seq_MESCs_Mouse1.64547085
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.64511213
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.61076483
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57021369
48FUS_26573619_Chip-Seq_HEK293_Human1.56720579
49* E2F1_21310950_ChIP-Seq_MCF-7_Human1.55452942
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.54497889
51GATA4_21415370_ChIP-Seq_HL-1_Mouse1.54452428
52EWS_26573619_Chip-Seq_HEK293_Human1.54403835
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53606944
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53352273
55AR_21909140_ChIP-Seq_LNCAP_Human1.52858036
56VDR_23849224_ChIP-Seq_CD4+_Human1.50729028
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49791729
58XRN2_22483619_ChIP-Seq_HELA_Human1.45810621
59MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.43696848
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41137915
61FOXP3_21729870_ChIP-Seq_TREG_Human1.41024608
62NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.37960599
63CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.36872048
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36682763
65MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36657362
66* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35030194
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.34951799
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34345616
69ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33806647
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33317248
71NANOG_16153702_ChIP-ChIP_HESCs_Human1.33125571
72TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32284925
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32114206
74NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.31621706
75* TBX20_22080862_ChIP-Seq_HEART_Mouse1.29341945
76* TBX20_22328084_ChIP-Seq_HEART_Mouse1.29341945
77KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28570396
78VDR_22108803_ChIP-Seq_LS180_Human1.28499735
79GABP_19822575_ChIP-Seq_HepG2_Human1.28404039
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.27854638
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.27828083
82ELF1_17652178_ChIP-ChIP_JURKAT_Human1.27611808
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.25761913
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24079046
85FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22788102
86KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.20815042
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18609722
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.17722952
89* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17576785
90* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.16487852
91ZNF274_21170338_ChIP-Seq_K562_Hela1.12647094
92* CBX2_27304074_Chip-Seq_ESCs_Mouse1.11688217
93ELK1_19687146_ChIP-ChIP_HELA_Human1.07649212
94EP300_21415370_ChIP-Seq_HL-1_Mouse1.05976539
95ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04801706
96SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.04783106
97TBX5_21415370_ChIP-Seq_HL-1_Mouse1.02880276
98TTF2_22483619_ChIP-Seq_HELA_Human1.02298606
99RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01990758
100MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99976167
101CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96987370
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96450385
103NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96049622
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91881585
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91545217
106CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91311053
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91099729
108YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90663283
109STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88448786
110TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.88335381
111SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87849658
112* NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87292126
113CIITA_25753668_ChIP-Seq_RAJI_Human0.84937627
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84197680
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83552790
116BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83020137
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.82331838
118IRF1_19129219_ChIP-ChIP_H3396_Human0.81124697
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80811018
120KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79671139
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.79152368
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.78087049
123ERG_20517297_ChIP-Seq_VCAP_Human0.77546029
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.75917221
125* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.75517535
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.75324265
127* SOX17_20123909_ChIP-Seq_XEN_Mouse0.74689389
128KDM5A_27292631_Chip-Seq_BREAST_Human0.74653363
129RNF2_27304074_Chip-Seq_NSC_Mouse0.74464962
130CTBP1_25329375_ChIP-Seq_LNCAP_Human0.74095728
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73816806
132PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73664208
133POU3F2_20337985_ChIP-ChIP_501MEL_Human0.73551257
134TCF3_18692474_ChIP-Seq_MEFs_Mouse0.71531366
135TAF15_26573619_Chip-Seq_HEK293_Human0.69699181
136ESR1_15608294_ChIP-ChIP_MCF-7_Human0.68581470
137CTBP2_25329375_ChIP-Seq_LNCAP_Human0.67621418
138E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.66323037
139GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.66259109
140FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.65752196
141EZH2_22144423_ChIP-Seq_EOC_Human0.65647708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.12234703
2MP0003646_muscle_fatigue4.87479752
3MP0002837_dystrophic_cardiac_calcinosis4.87147530
4MP0003136_yellow_coat_color4.02902248
5MP0003806_abnormal_nucleotide_metabolis3.90083213
6MP0004084_abnormal_cardiac_muscle3.89251349
7MP0000749_muscle_degeneration3.69877812
8MP0004215_abnormal_myocardial_fiber3.37476370
9MP0005330_cardiomyopathy3.37458782
10MP0010030_abnormal_orbit_morphology3.35940149
11MP0006036_abnormal_mitochondrial_physio3.32187026
12MP0000751_myopathy3.29887257
13MP0004036_abnormal_muscle_relaxation3.23211162
14MP0002139_abnormal_hepatobiliary_system3.10880679
15MP0002938_white_spotting3.01597642
16MP0005360_urolithiasis3.01373947
17MP0008058_abnormal_DNA_repair2.85910109
18MP0000566_synostosis2.84046221
19MP0004130_abnormal_muscle_cell2.70150468
20MP0010094_abnormal_chromosome_stability2.61642330
21MP0005085_abnormal_gallbladder_physiolo2.59084391
22MP0004087_abnormal_muscle_fiber2.46063413
23MP0006292_abnormal_olfactory_placode2.41222677
24MP0001529_abnormal_vocalization2.34961952
25MP0005670_abnormal_white_adipose2.33469708
26MP0003693_abnormal_embryo_hatching2.30651410
27MP0008775_abnormal_heart_ventricle2.26322057
28MP0002972_abnormal_cardiac_muscle2.23093557
29MP0000372_irregular_coat_pigmentation2.18549283
30MP0002269_muscular_atrophy2.13379069
31MP0000750_abnormal_muscle_regeneration2.12334902
32MP0005365_abnormal_bile_salt2.11185625
33MP0006035_abnormal_mitochondrial_morpho2.06897543
34MP0005620_abnormal_muscle_contractility2.05874869
35MP0005666_abnormal_adipose_tissue2.05873279
36MP0003221_abnormal_cardiomyocyte_apopto2.02592774
37MP0005385_cardiovascular_system_phenoty2.00338704
38MP0001544_abnormal_cardiovascular_syste2.00338704
39MP0002106_abnormal_muscle_physiology2.00080207
40MP0003890_abnormal_embryonic-extraembry1.95948630
41MP0003137_abnormal_impulse_conducting1.95809351
42MP0001293_anophthalmia1.94400984
43MP0008932_abnormal_embryonic_tissue1.90111696
44MP0003077_abnormal_cell_cycle1.89279090
45MP0005332_abnormal_amino_acid1.88496608
46MP0010630_abnormal_cardiac_muscle1.84736312
47MP0000747_muscle_weakness1.83101220
48MP0003186_abnormal_redox_activity1.78127362
49MP0003111_abnormal_nucleus_morphology1.77556324
50MP0004145_abnormal_muscle_electrophysio1.74584695
51MP0001346_abnormal_lacrimal_gland1.71896970
52MP0006138_congestive_heart_failure1.69304663
53MP0000759_abnormal_skeletal_muscle1.63399281
54MP0002234_abnormal_pharynx_morphology1.62845648
55MP0004484_altered_response_of1.61561396
56MP0003195_calcinosis1.60067322
57MP0008995_early_reproductive_senescence1.58893894
58MP0006072_abnormal_retinal_apoptosis1.58135399
59MP0005171_absent_coat_pigmentation1.57900087
60MP0005369_muscle_phenotype1.57636890
61MP0008875_abnormal_xenobiotic_pharmacok1.56789595
62MP0004147_increased_porphyrin_level1.55810435
63MP0004185_abnormal_adipocyte_glucose1.54093250
64MP0004043_abnormal_pH_regulation1.50997722
65MP0003718_maternal_effect1.50380285
66MP0002697_abnormal_eye_size1.44078174
67MP0001286_abnormal_eye_development1.43935324
68MP0005083_abnormal_biliary_tract1.43277625
69MP0003937_abnormal_limbs/digits/tail_de1.43044291
70MP0003315_abnormal_perineum_morphology1.41424503
71MP0003283_abnormal_digestive_organ1.38016576
72MP0000537_abnormal_urethra_morphology1.37555341
73MP0005266_abnormal_metabolism1.36993012
74MP0002102_abnormal_ear_morphology1.36413758
75MP0002638_abnormal_pupillary_reflex1.32189628
76MP0002332_abnormal_exercise_endurance1.31527980
77MP0010329_abnormal_lipoprotein_level1.30534304
78MP0002971_abnormal_brown_adipose1.28298284
79MP0005319_abnormal_enzyme/_coenzyme1.28264166
80MP0004142_abnormal_muscle_tone1.27835531
81MP0008007_abnormal_cellular_replicative1.27259402
82MP0008789_abnormal_olfactory_epithelium1.27000525
83MP0003950_abnormal_plasma_membrane1.25196337
84MP0009697_abnormal_copulation1.23263222
85MP0003656_abnormal_erythrocyte_physiolo1.21410333
86MP0005584_abnormal_enzyme/coenzyme_acti1.21210545
87MP0000631_abnormal_neuroendocrine_gland1.18617985
88MP0005084_abnormal_gallbladder_morpholo1.18109177
89MP0002118_abnormal_lipid_homeostasis1.15791532
90MP0000049_abnormal_middle_ear1.15444853
91MP0004233_abnormal_muscle_weight1.15137818
92MP0005451_abnormal_body_composition1.14005639
93MP0005375_adipose_tissue_phenotype1.13817125
94MP0009840_abnormal_foam_cell1.13370013
95MP0004085_abnormal_heartbeat1.11369361
96MP0001666_abnormal_nutrient_absorption1.10306027
97MP0003119_abnormal_digestive_system1.08239406
98MP0003880_abnormal_central_pattern1.07793247
99MP0004133_heterotaxia1.07755955
100MP0002127_abnormal_cardiovascular_syste1.07728063
101MP0003567_abnormal_fetal_cardiomyocyte1.06851958
102MP0003938_abnormal_ear_development1.06364305
103MP0009643_abnormal_urine_homeostasis1.05934132
104MP0002751_abnormal_autonomic_nervous1.05441854
105MP0003828_pulmonary_edema1.05202399
106MP0000609_abnormal_liver_physiology1.01474860
107MP0002277_abnormal_respiratory_mucosa1.01301054
108MP0005187_abnormal_penis_morphology1.00658583
109MP0001299_abnormal_eye_distance/1.00549714
110MP0002282_abnormal_trachea_morphology0.99971091
111MP0002210_abnormal_sex_determination0.99884483
112MP0003252_abnormal_bile_duct0.99075735
113MP0002095_abnormal_skin_pigmentation0.98400638
114MP0005391_vision/eye_phenotype0.97400327
115MP0005253_abnormal_eye_physiology0.96568328
116MP0003786_premature_aging0.95578266
117MP0002233_abnormal_nose_morphology0.93739968
118MP0003941_abnormal_skin_development0.93677459
119MP0000569_abnormal_digit_pigmentation0.93379967
120MP0000343_altered_response_to0.92468832
121MP0000778_abnormal_nervous_system0.92323431
122MP0002085_abnormal_embryonic_tissue0.91692975
123MP0002822_catalepsy0.90130679
124MP0001485_abnormal_pinna_reflex0.89900223
125MP0005499_abnormal_olfactory_system0.89846220
126MP0005394_taste/olfaction_phenotype0.89846220
127MP0009672_abnormal_birth_weight0.89692170
128MP0002084_abnormal_developmental_patter0.87537829
129MP0006276_abnormal_autonomic_nervous0.86315564
130MP0001764_abnormal_homeostasis0.85337175
131MP0009250_abnormal_appendicular_skeleto0.84930257
132MP0001324_abnormal_eye_pigmentation0.84569627
133MP0000647_abnormal_sebaceous_gland0.82176121
134MP0000026_abnormal_inner_ear0.82050260
135MP0002092_abnormal_eye_morphology0.81452842
136MP0001697_abnormal_embryo_size0.80979991
137MP0002078_abnormal_glucose_homeostasis0.80759827
138MP0002653_abnormal_ependyma_morphology0.80553768
139MP0001929_abnormal_gametogenesis0.80042902
140MP0002736_abnormal_nociception_after0.79332418
141MP0004742_abnormal_vestibular_system0.78722438
142MP0005636_abnormal_mineral_homeostasis0.77823076
143MP0000350_abnormal_cell_proliferation0.77517766
144MP0005165_increased_susceptibility_to0.76781524
145MP0001672_abnormal_embryogenesis/_devel0.76205714
146MP0005380_embryogenesis_phenotype0.76205714
147MP0003705_abnormal_hypodermis_morpholog0.75923060
148MP0000579_abnormal_nail_morphology0.75470567
149MP0003861_abnormal_nervous_system0.74942541
150MP0008877_abnormal_DNA_methylation0.73800356
151MP0003755_abnormal_palate_morphology0.73502592
152MP0002111_abnormal_tail_morphology0.73429596
153MP0001145_abnormal_male_reproductive0.73353094
154MP0000266_abnormal_heart_morphology0.73178061
155MP0003121_genomic_imprinting0.72902044
156MP0000653_abnormal_sex_gland0.72156738
157MP0000230_abnormal_systemic_arterial0.71351421
158MP0005376_homeostasis/metabolism_phenot0.69596826
159MP0005408_hypopigmentation0.69400363
160MP0004957_abnormal_blastocyst_morpholog0.68521739
161MP0003011_delayed_dark_adaptation0.65789196
162MP0005535_abnormal_body_temperature0.64367618
163MP0000358_abnormal_cell_content/0.62822171
164MP0003191_abnormal_cellular_cholesterol0.61953611
165MP0002970_abnormal_white_adipose0.61062410
166MP0010368_abnormal_lymphatic_system0.60329093
167MP0000598_abnormal_liver_morphology0.58793772
168MP0005334_abnormal_fat_pad0.58270848
169MP0002108_abnormal_muscle_morphology0.57147934
170MP0003279_aneurysm0.56540399
171MP0004510_myositis0.56017425
172MP0001727_abnormal_embryo_implantation0.54863746
173MP0001661_extended_life_span0.49583911
174MP0002128_abnormal_blood_circulation0.49457695
175MP0004019_abnormal_vitamin_homeostasis0.49331711
176MP0001756_abnormal_urination0.48254535
177MP0001730_embryonic_growth_arrest0.47990847
178MP0003984_embryonic_growth_retardation0.45312869
179MP0009763_increased_sensitivity_to0.44256277
180MP0000013_abnormal_adipose_tissue0.44131636
181MP0009642_abnormal_blood_homeostasis0.44067190
182MP0006054_spinal_hemorrhage0.43681019
183MP0002088_abnormal_embryonic_growth/wei0.42988639

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.60918039
2Abnormality of cells of the erythroid lineage (HP:0012130)5.19296464
3Abnormal number of erythroid precursors (HP:0012131)5.17293344
4Myoglobinuria (HP:0002913)5.14459071
5Acute necrotizing encephalopathy (HP:0006965)4.92755279
6Abnormal mitochondria in muscle tissue (HP:0008316)4.87281299
7Exercise-induced muscle cramps (HP:0003710)4.79024853
8Acute encephalopathy (HP:0006846)4.74807058
9Hepatic necrosis (HP:0002605)4.70046478
10Rhabdomyolysis (HP:0003201)4.60074017
11Macrocytic anemia (HP:0001972)4.46883268
12Sudden death (HP:0001699)4.43824942
13Exercise-induced myalgia (HP:0003738)4.40085730
14Cerebral edema (HP:0002181)4.34619183
15Hypoglycemic coma (HP:0001325)4.26937937
16Abnormality of fatty-acid metabolism (HP:0004359)4.14281102
17Progressive macrocephaly (HP:0004481)4.09827603
18Mitochondrial inheritance (HP:0001427)4.06599632
19Increased serum pyruvate (HP:0003542)4.02759843
20Abnormality of glycolysis (HP:0004366)4.02759843
21Calf muscle hypertrophy (HP:0008981)4.01963910
22Ventricular tachycardia (HP:0004756)4.01342393
23Hepatocellular necrosis (HP:0001404)3.99258132
24Abnormality of dicarboxylic acid metabolism (HP:0010995)3.97610449
25Dicarboxylic aciduria (HP:0003215)3.97610449
26Increased CSF lactate (HP:0002490)3.95582102
27Muscle hypertrophy of the lower extremities (HP:0008968)3.82786787
28Palpitations (HP:0001962)3.68658122
29Increased muscle lipid content (HP:0009058)3.67389972
30Generalized aminoaciduria (HP:0002909)3.53488699
31Lactic acidosis (HP:0003128)3.47132418
32Lipoatrophy (HP:0100578)3.45093387
33Ketoacidosis (HP:0001993)3.43129239
34Muscle fiber splitting (HP:0003555)3.40815459
35Hyperammonemia (HP:0001987)3.37401440
36Pallor (HP:0000980)3.30184426
37Increased intramyocellular lipid droplets (HP:0012240)3.30031929
38Hyperglycinuria (HP:0003108)3.25438294
39Lipid accumulation in hepatocytes (HP:0006561)3.23974301
40Dilated cardiomyopathy (HP:0001644)3.22919573
41Congenital, generalized hypertrichosis (HP:0004540)3.21903624
42Ketosis (HP:0001946)3.19032942
43Abnormality of the calf musculature (HP:0001430)3.18978207
44Exercise intolerance (HP:0003546)3.16919794
45Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.11005961
46Decreased activity of mitochondrial respiratory chain (HP:0008972)3.11005961
47Respiratory failure (HP:0002878)3.09641033
48Conjunctival hamartoma (HP:0100780)3.09617635
49Renal Fanconi syndrome (HP:0001994)3.06309269
50Lethargy (HP:0001254)3.02562080
51Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.02419869
52Atrial fibrillation (HP:0005110)3.02068890
53Hyporeflexia of lower limbs (HP:0002600)2.98562298
54Abnormality of serine family amino acid metabolism (HP:0010894)2.96168655
55Abnormality of glycine metabolism (HP:0010895)2.96168655
56Septo-optic dysplasia (HP:0100842)2.92341342
57Nausea (HP:0002018)2.88804328
58Right ventricular cardiomyopathy (HP:0011663)2.85916673
59Colon cancer (HP:0003003)2.84192335
60Increased serum lactate (HP:0002151)2.80729117
61Supraventricular tachycardia (HP:0004755)2.76166807
62Primary atrial arrhythmia (HP:0001692)2.76007281
63Increased hepatocellular lipid droplets (HP:0006565)2.74756606
64Ragged-red muscle fibers (HP:0003200)2.72192385
65Abnormality of the left ventricular outflow tract (HP:0011103)2.70094857
66Subaortic stenosis (HP:0001682)2.70094857
67Metabolic acidosis (HP:0001942)2.69566022
68Supraventricular arrhythmia (HP:0005115)2.68994922
69Muscle stiffness (HP:0003552)2.62344847
70Glycosuria (HP:0003076)2.62161738
71Abnormality of urine glucose concentration (HP:0011016)2.62161738
72Abnormality of alanine metabolism (HP:0010916)2.59956505
73Hyperalaninemia (HP:0003348)2.59956505
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.59956505
75EMG: myopathic abnormalities (HP:0003458)2.59906971
76Increased connective tissue (HP:0009025)2.58621436
77Proximal tubulopathy (HP:0000114)2.58611787
78Muscle fiber inclusion bodies (HP:0100299)2.53674598
79Asymmetric septal hypertrophy (HP:0001670)2.52829351
80Absent septum pellucidum (HP:0001331)2.49969589
813-Methylglutaconic aciduria (HP:0003535)2.48434497
82Triphalangeal thumb (HP:0001199)2.47795358
83Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.47294707
84Multiple enchondromatosis (HP:0005701)2.46231645
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45498180
86Exertional dyspnea (HP:0002875)2.44997527
87Vomiting (HP:0002013)2.44853153
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.42038236
89Leukodystrophy (HP:0002415)2.40846748
90Bilateral microphthalmos (HP:0007633)2.40110939
91Abnormality of the labia minora (HP:0012880)2.37958774
92Partial duplication of thumb phalanx (HP:0009944)2.37778721
93Hyperglycinemia (HP:0002154)2.37655611
94Respiratory difficulties (HP:0002880)2.37147571
95Methylmalonic aciduria (HP:0012120)2.33617049
96Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32936043
97Aplasia/Hypoplasia of the uvula (HP:0010293)2.32210702
98Meckel diverticulum (HP:0002245)2.31419051
99Pheochromocytoma (HP:0002666)2.30566990
100Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30407088
101Partial duplication of the phalanx of hand (HP:0009999)2.27722627
102Abnormality of serum amino acid levels (HP:0003112)2.25514540
103Myotonia (HP:0002486)2.25401788
104Syncope (HP:0001279)2.25276044
105Esophageal atresia (HP:0002032)2.24248715
106Chromsome breakage (HP:0040012)2.24140121
107Hypoalphalipoproteinemia (HP:0003233)2.24014708
108CNS demyelination (HP:0007305)2.20678286
109Neoplasm of the adrenal gland (HP:0100631)2.20201099
110Renal cortical cysts (HP:0000803)2.19607823
111Hypolipoproteinemia (HP:0010981)2.19357155
112Neuroendocrine neoplasm (HP:0100634)2.18968984
113Abnormality of the pons (HP:0007361)2.18752765
114Abnormality of the ileum (HP:0001549)2.18129133
115Hypobetalipoproteinemia (HP:0003563)2.16392670
116Difficulty running (HP:0009046)2.16246885
117Intrahepatic cholestasis (HP:0001406)2.16212282
118Optic disc pallor (HP:0000543)2.13867835
119Nemaline bodies (HP:0003798)2.13814458
120Abnormality of the septum pellucidum (HP:0007375)2.13648839
121Ventricular arrhythmia (HP:0004308)2.11748875
122Hypoplasia of the pons (HP:0012110)2.11241439
123Xanthomatosis (HP:0000991)2.10750447
124Birth length less than 3rd percentile (HP:0003561)2.10072577
125Rimmed vacuoles (HP:0003805)2.09227764
126Maternal diabetes (HP:0009800)2.09197888
127Duplication of thumb phalanx (HP:0009942)2.09075827
128Prolonged QT interval (HP:0001657)2.05380426
129Cholelithiasis (HP:0001081)2.05301675
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03987684
131Esophageal neoplasm (HP:0100751)2.03860779
132Neoplasm of head and neck (HP:0012288)2.03860779
133Type I transferrin isoform profile (HP:0003642)2.01564081
134Absent thumb (HP:0009777)1.98260346
135Microvesicular hepatic steatosis (HP:0001414)1.96421009
136Abnormality of the parietal bone (HP:0002696)1.95314208
137Depressed nasal ridge (HP:0000457)1.92762277
138Abnormality of reticulocytes (HP:0004312)1.88479454
139Abnormality of the preputium (HP:0100587)1.86813185
140Shoulder girdle muscle weakness (HP:0003547)1.84360038
141Abnormal number of incisors (HP:0011064)1.84004051
142Duplicated collecting system (HP:0000081)1.83965946
143Duodenal stenosis (HP:0100867)1.81684398
144Small intestinal stenosis (HP:0012848)1.81684398
145Degeneration of anterior horn cells (HP:0002398)1.81325807
146Abnormality of the anterior horn cell (HP:0006802)1.81325807
147Abnormality of renal resorption (HP:0011038)1.80588762
148Stenosis of the external auditory canal (HP:0000402)1.79853234
149True hermaphroditism (HP:0010459)1.77207870
150Gastrointestinal atresia (HP:0002589)1.76865984
151Pancreatic fibrosis (HP:0100732)1.76856528
152Pancreatic cysts (HP:0001737)1.72863642
153Abnormality of chromosome stability (HP:0003220)1.72567080
154Abnormality of methionine metabolism (HP:0010901)1.71236054
155Concave nail (HP:0001598)1.71029623
156Abnormal lung lobation (HP:0002101)1.69586814
157Abnormality of the duodenum (HP:0002246)1.68204607
158Deformed tarsal bones (HP:0008119)1.67042596
159Anophthalmia (HP:0000528)1.66803029
160Calcaneovalgus deformity (HP:0001848)1.66512073
161Aplastic anemia (HP:0001915)1.65404575
162Hemivertebrae (HP:0002937)1.59732952
163Methylmalonic acidemia (HP:0002912)1.57148235
164Optic nerve hypoplasia (HP:0000609)1.55918654
165Abnormality of the renal collecting system (HP:0004742)1.55697089

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.96291475
2VRK24.87879037
3OBSCN4.26881762
4TTN4.06416066
5PDK33.90902838
6PDK43.90902838
7LMTK23.11555459
8NEK13.05984554
9NME23.02153039
10PKN22.76661485
11TSSK62.74176923
12SRPK12.72069369
13MYLK2.67358755
14PASK2.63295493
15PNCK2.53553045
16PHKG12.51894955
17PHKG22.51894955
18PDK22.28633707
19TRIB32.20458883
20PLK32.12909296
21PIK3CA1.98106796
22MKNK11.87887456
23MUSK1.87105938
24TAF11.80137082
25EPHB21.71931440
26WNK31.65113835
27MAPK151.55996080
28EIF2AK11.46512193
29PINK11.46154746
30DYRK31.42847602
31STK241.42743383
32NUAK11.38748750
33WNK41.37941213
34FLT31.37646739
35CCNB11.37623414
36BUB11.37564989
37KDR1.37399513
38BRSK21.35862542
39TIE11.33837042
40ILK1.30116586
41DYRK21.26900410
42MKNK21.22602962
43NEK21.21697524
44CHEK21.19213382
45BMPR1B1.14733084
46NEK91.14371422
47MAP2K31.11784084
48NME11.11188937
49CDK81.09647357
50WEE11.06976357
51MAPKAPK31.06220835
52LRRK21.03327931
53ZAK1.01896515
54STK391.00800570
55TNIK1.00111625
56PIK3CG0.90420357
57STK38L0.89767789
58STK160.88978749
59STK40.88835062
60INSRR0.86867307
61FGFR20.86636615
62RPS6KB20.86298472
63ATR0.83574311
64PRKAA20.83121093
65LIMK10.78549189
66MAP3K40.74810486
67CDK190.73745919
68MAP3K100.72040711
69DMPK0.71807310
70MAPK120.71661361
71MAP3K30.70158739
72PRKAA10.66587817
73SIK10.64895085
74CAMK2D0.64783384
75EIF2AK20.64483474
76TESK20.64376397
77ACVR1B0.63985193
78PRKD10.63459854
79GRK70.61013409
80CDK30.60355860
81AURKB0.59552840
82MST1R0.59265128
83TGFBR10.58594877
84MAPK110.58159786
85EIF2AK30.57787040
86TRPM70.57298543
87ABL20.56720081
88MAP4K20.55635485
89CDC70.54510992
90VRK10.54459229
91DAPK30.54441206
92CDK70.54351736
93TLK10.54228995
94CDK40.52969785
95PRKG20.52404250
96ROCK10.50933616
97TRIM280.49892586
98ATM0.49401829
99AKT20.48694136
100MAP3K110.48669933
101TTK0.48558782
102MST40.48096360
103MAP3K80.47302538
104CHEK10.46688782
105PRKCG0.46365860
106TESK10.46114898
107TAOK20.45732799
108CSNK1E0.41701763
109FGFR10.41190267
110CAMK2G0.40933068
111MAP3K70.40866086
112RPS6KL10.39497130
113RPS6KC10.39497130
114MAP3K50.38917023
115MAP2K70.38896427
116MARK10.38227050
117ERBB40.38161507
118STK100.36971362
119PRKACB0.36670074
120CDK10.36027331
121PRKACG0.35989654
122PAK30.35652014
123ERBB30.35583050
124ADRBK20.35240054
125MAPKAPK50.34977104
126PKN10.34751827
127CDK20.34135828
128MAPK130.33666444
129PIM20.33450465
130RPS6KA60.33189419
131GRK10.32620901
132PLK20.32522701
133AURKA0.32100863
134BRSK10.30975849
135UHMK10.30498121
136PLK40.29343936
137CSNK2A10.28724063
138ADRBK10.28392964
139PBK0.28391117
140FGFR40.26966826
141STK30.26271079
142* PRKACA0.25946895
143CSNK2A20.25470332
144PRKDC0.24866746
145RPS6KA40.24861667
146ROCK20.24290374
147RPS6KA50.23418940
148EPHA40.23311881
149MARK30.22868058
150ERN10.22579618
151PLK10.22180196
152EPHB10.22084537
153MAPK40.20727651
154ALK0.20679281
155MET0.20584085
156PRKG10.20421094
157CDK11A0.20242383

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.76805534
2Propanoate metabolism_Homo sapiens_hsa006403.61471819
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.61456624
4Oxidative phosphorylation_Homo sapiens_hsa001903.15195126
5Fatty acid degradation_Homo sapiens_hsa000713.06508064
6Parkinsons disease_Homo sapiens_hsa050123.06091033
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.04849219
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.78462415
9Carbon metabolism_Homo sapiens_hsa012002.61913336
10Fatty acid metabolism_Homo sapiens_hsa012122.42450468
11Pyruvate metabolism_Homo sapiens_hsa006202.40861517
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.39035083
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21203166
14Cardiac muscle contraction_Homo sapiens_hsa042602.14570400
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14180075
16Alzheimers disease_Homo sapiens_hsa050102.10238622
17Fatty acid elongation_Homo sapiens_hsa000622.07692587
18Huntingtons disease_Homo sapiens_hsa050162.01917068
19Butanoate metabolism_Homo sapiens_hsa006501.98660117
20Fanconi anemia pathway_Homo sapiens_hsa034601.77860749
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.77427506
22Biosynthesis of amino acids_Homo sapiens_hsa012301.68813162
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65911462
24Tryptophan metabolism_Homo sapiens_hsa003801.65183175
25Peroxisome_Homo sapiens_hsa041461.64697136
26PPAR signaling pathway_Homo sapiens_hsa033201.61969768
27RNA transport_Homo sapiens_hsa030131.61894820
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.51097672
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50880718
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49124597
31Ribosome_Homo sapiens_hsa030101.48606202
32Basal transcription factors_Homo sapiens_hsa030221.42449954
33Non-homologous end-joining_Homo sapiens_hsa034501.39898111
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.37493959
35Cell cycle_Homo sapiens_hsa041101.36887245
36Sulfur metabolism_Homo sapiens_hsa009201.34920089
37Proteasome_Homo sapiens_hsa030501.33488019
38beta-Alanine metabolism_Homo sapiens_hsa004101.28200609
39Arginine biosynthesis_Homo sapiens_hsa002201.27370358
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.19434783
41Starch and sucrose metabolism_Homo sapiens_hsa005001.08133292
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02808634
43Arginine and proline metabolism_Homo sapiens_hsa003301.02441746
44Basal cell carcinoma_Homo sapiens_hsa052171.02302508
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01081489
46Phenylalanine metabolism_Homo sapiens_hsa003600.98950135
47Folate biosynthesis_Homo sapiens_hsa007900.94427017
48Tyrosine metabolism_Homo sapiens_hsa003500.93286983
49Nitrogen metabolism_Homo sapiens_hsa009100.90929192
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.90652639
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90338556
52Pentose phosphate pathway_Homo sapiens_hsa000300.88356730
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.87912916
54Fat digestion and absorption_Homo sapiens_hsa049750.87065963
55Selenocompound metabolism_Homo sapiens_hsa004500.86614163
56Glutathione metabolism_Homo sapiens_hsa004800.85548883
57Dilated cardiomyopathy_Homo sapiens_hsa054140.84879066
58Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84269733
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.83108807
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80293760
61Metabolic pathways_Homo sapiens_hsa011000.79822698
62DNA replication_Homo sapiens_hsa030300.79591583
63Fructose and mannose metabolism_Homo sapiens_hsa000510.76075362
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.71845282
65Galactose metabolism_Homo sapiens_hsa000520.70437348
66One carbon pool by folate_Homo sapiens_hsa006700.69287004
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69112122
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67724373
69Sulfur relay system_Homo sapiens_hsa041220.67583331
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67206676
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66866246
72Fatty acid biosynthesis_Homo sapiens_hsa000610.65152639
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64658449
74Chemical carcinogenesis_Homo sapiens_hsa052040.62982165
75Hedgehog signaling pathway_Homo sapiens_hsa043400.60687212
76mRNA surveillance pathway_Homo sapiens_hsa030150.60431351
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.59375210
78Histidine metabolism_Homo sapiens_hsa003400.58350231
79Pyrimidine metabolism_Homo sapiens_hsa002400.58127910
80Mismatch repair_Homo sapiens_hsa034300.57722190
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54609631
82Caffeine metabolism_Homo sapiens_hsa002320.50426900
83Phototransduction_Homo sapiens_hsa047440.50261165
84Oocyte meiosis_Homo sapiens_hsa041140.49638976
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49493083
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.47982624
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46341843
88Glycerolipid metabolism_Homo sapiens_hsa005610.46167480
89Lysine degradation_Homo sapiens_hsa003100.44795268
90p53 signaling pathway_Homo sapiens_hsa041150.43721619
91Protein export_Homo sapiens_hsa030600.42849151
92Glucagon signaling pathway_Homo sapiens_hsa049220.42795528
93RNA polymerase_Homo sapiens_hsa030200.42305680
94Retinol metabolism_Homo sapiens_hsa008300.40283827
95Bile secretion_Homo sapiens_hsa049760.38805080
96Complement and coagulation cascades_Homo sapiens_hsa046100.37090402
97Nucleotide excision repair_Homo sapiens_hsa034200.36139945
98Insulin resistance_Homo sapiens_hsa049310.35824542
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.35272131
100Viral myocarditis_Homo sapiens_hsa054160.35069493
101AMPK signaling pathway_Homo sapiens_hsa041520.34114619
102Alcoholism_Homo sapiens_hsa050340.32376066
103Vitamin B6 metabolism_Homo sapiens_hsa007500.31327362
104TGF-beta signaling pathway_Homo sapiens_hsa043500.31223676
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29849214
106Purine metabolism_Homo sapiens_hsa002300.29546079
107Base excision repair_Homo sapiens_hsa034100.28417164
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.28249169
109Vitamin digestion and absorption_Homo sapiens_hsa049770.26995614
110ABC transporters_Homo sapiens_hsa020100.26131686
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25698766
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.24587790
113Wnt signaling pathway_Homo sapiens_hsa043100.23215998
114Systemic lupus erythematosus_Homo sapiens_hsa053220.23039165
115Steroid biosynthesis_Homo sapiens_hsa001000.22299923
116Linoleic acid metabolism_Homo sapiens_hsa005910.22228234
117Epstein-Barr virus infection_Homo sapiens_hsa051690.21254025
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21071532
119Hippo signaling pathway_Homo sapiens_hsa043900.20710188
120RNA degradation_Homo sapiens_hsa030180.20423032
121Homologous recombination_Homo sapiens_hsa034400.19071146
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.19005346
123Insulin signaling pathway_Homo sapiens_hsa049100.18979194
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.18630496
125Spliceosome_Homo sapiens_hsa030400.15327339
126N-Glycan biosynthesis_Homo sapiens_hsa005100.13463659
127Nicotine addiction_Homo sapiens_hsa050330.12288694
128Taste transduction_Homo sapiens_hsa047420.09871742

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