CHCHD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)8.01109034
2ATP synthesis coupled proton transport (GO:0015986)7.51719373
3energy coupled proton transport, down electrochemical gradient (GO:0015985)7.51719373
4ribosomal small subunit biogenesis (GO:0042274)6.79290888
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)6.72407184
6viral transcription (GO:0019083)6.57518533
7ribosomal small subunit assembly (GO:0000028)6.41742425
8translational termination (GO:0006415)6.37090131
9respiratory electron transport chain (GO:0022904)6.03021160
10electron transport chain (GO:0022900)5.87933274
11cotranslational protein targeting to membrane (GO:0006613)5.77522325
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.75613331
13protein targeting to ER (GO:0045047)5.69430825
14maturation of SSU-rRNA (GO:0030490)5.44352126
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.43656006
16protein localization to endoplasmic reticulum (GO:0070972)5.43211797
17translational elongation (GO:0006414)5.37518131
18protein neddylation (GO:0045116)5.11809214
19cellular protein complex disassembly (GO:0043624)5.02163586
20viral life cycle (GO:0019058)5.00926592
21proteasome assembly (GO:0043248)4.97352546
22ribosomal large subunit biogenesis (GO:0042273)4.89619889
23chaperone-mediated protein transport (GO:0072321)4.88550454
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.80372678
25mitochondrial respiratory chain complex I assembly (GO:0032981)4.80372678
26NADH dehydrogenase complex assembly (GO:0010257)4.80372678
27protein complex biogenesis (GO:0070271)4.78950116
28nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.69324745
29translational initiation (GO:0006413)4.66160943
30establishment of protein localization to mitochondrial membrane (GO:0090151)4.50732105
31translation (GO:0006412)4.50105656
32GTP biosynthetic process (GO:0006183)4.49911238
33mitochondrial respiratory chain complex assembly (GO:0033108)4.44416016
34establishment of integrated proviral latency (GO:0075713)4.28536608
35termination of RNA polymerase III transcription (GO:0006386)4.22351042
36transcription elongation from RNA polymerase III promoter (GO:0006385)4.22351042
37protein complex disassembly (GO:0043241)4.19956618
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.04688387
39macromolecular complex disassembly (GO:0032984)4.02697743
40regulation of mitochondrial translation (GO:0070129)4.00301496
41chromatin remodeling at centromere (GO:0031055)3.98379085
42CENP-A containing nucleosome assembly (GO:0034080)3.92103150
43UTP biosynthetic process (GO:0006228)3.91478566
44purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.84858165
45regulation of cellular amino acid metabolic process (GO:0006521)3.81355178
46purine nucleoside triphosphate biosynthetic process (GO:0009145)3.78990138
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.77743510
48negative regulation of ligase activity (GO:0051352)3.77743510
49establishment of viral latency (GO:0019043)3.73001264
50rRNA modification (GO:0000154)3.72418980
51protein targeting to membrane (GO:0006612)3.71516938
52cellular component biogenesis (GO:0044085)3.69801271
53DNA deamination (GO:0045006)3.69366938
54oxidative phosphorylation (GO:0006119)3.69278465
55respiratory chain complex IV assembly (GO:0008535)3.68953784
56ribonucleoprotein complex biogenesis (GO:0022613)3.68953374
57cullin deneddylation (GO:0010388)3.68701822
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67890000
59ATP biosynthetic process (GO:0006754)3.66271573
60DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.65299138
61protein targeting to mitochondrion (GO:0006626)3.63810585
627-methylguanosine mRNA capping (GO:0006370)3.63286837
63guanosine-containing compound biosynthetic process (GO:1901070)3.62681105
647-methylguanosine RNA capping (GO:0009452)3.61962506
65RNA capping (GO:0036260)3.61962506
66L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.61366509
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.57662477
68establishment of protein localization to mitochondrion (GO:0072655)3.57287095
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.56698173
70signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.56342670
71intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.56342670
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53507276
73exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.51251805
74signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.51178648
75signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.51178648
76signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.51178648
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.49349259
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.49349259
79ribonucleoside triphosphate biosynthetic process (GO:0009201)3.45480213
80nuclear-transcribed mRNA catabolic process (GO:0000956)3.42518308
81UTP metabolic process (GO:0046051)3.41548945
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.41516219
83signal transduction involved in DNA damage checkpoint (GO:0072422)3.41064261
84signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41064261
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.40967757
86protein deneddylation (GO:0000338)3.40491258
87mitochondrial transport (GO:0006839)3.39344818
88hydrogen ion transmembrane transport (GO:1902600)3.38816380
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.38144340
90DNA damage response, detection of DNA damage (GO:0042769)3.36790789
91spliceosomal complex assembly (GO:0000245)3.35275429
92protein localization to mitochondrion (GO:0070585)3.32084005
93CTP metabolic process (GO:0046036)3.31953840
94CTP biosynthetic process (GO:0006241)3.31953840
95rRNA processing (GO:0006364)3.30982680
96spliceosomal snRNP assembly (GO:0000387)3.30860256
97antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.30446208
98cytochrome complex assembly (GO:0017004)3.29648898
99inner mitochondrial membrane organization (GO:0007007)3.25590655
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.24936459
101intracellular protein transmembrane import (GO:0044743)3.24722519
102nucleoside triphosphate biosynthetic process (GO:0009142)3.23351165
103mRNA catabolic process (GO:0006402)3.21995111
104formation of translation preinitiation complex (GO:0001731)3.17936056
105transcription elongation from RNA polymerase I promoter (GO:0006362)3.17221099
106rRNA metabolic process (GO:0016072)3.17012489
107DNA replication checkpoint (GO:0000076)3.15096371
108aerobic respiration (GO:0009060)3.14481011
109RNA catabolic process (GO:0006401)3.14167067
110pseudouridine synthesis (GO:0001522)3.13161772
111peptidyl-histidine modification (GO:0018202)3.12434466
112water-soluble vitamin biosynthetic process (GO:0042364)3.12405898
113pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.11092460
114pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.10863181
115pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.10746902
116histone exchange (GO:0043486)3.10709513
117kinetochore assembly (GO:0051382)3.09348680
118positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08367903
119proton transport (GO:0015992)3.03547509

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.83825662
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.16920761
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.61868003
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.43998102
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.11782404
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.91275737
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.83927772
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.62473370
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.57588684
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.49884106
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.36377848
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.29967680
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.29094364
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.25849503
15* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.03939396
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87632214
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60165978
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53934135
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52504712
20VDR_23849224_ChIP-Seq_CD4+_Human2.51037698
21DCP1A_22483619_ChIP-Seq_HELA_Human2.37896464
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.33653351
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.32015272
24ELK1_19687146_ChIP-ChIP_HELA_Human2.27607726
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.27149045
26XRN2_22483619_ChIP-Seq_HELA_Human2.22494297
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.17429679
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.15663140
29TTF2_22483619_ChIP-Seq_HELA_Human2.14706562
30FOXP3_21729870_ChIP-Seq_TREG_Human2.07671309
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.06789513
32E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01534618
33E2F7_22180533_ChIP-Seq_HELA_Human1.97391401
34* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.93791214
35FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79241202
36* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73627554
37CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.72730052
38GABP_19822575_ChIP-Seq_HepG2_Human1.65531866
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.63956600
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62689709
41ELK1_22589737_ChIP-Seq_MCF10A_Human1.61728616
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58181301
43IRF1_19129219_ChIP-ChIP_H3396_Human1.57877918
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.52747904
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.49503531
46MYC_18940864_ChIP-ChIP_HL60_Human1.48856144
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.42008564
48VDR_22108803_ChIP-Seq_LS180_Human1.41282690
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36511107
50POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36074239
51BP1_19119308_ChIP-ChIP_Hs578T_Human1.35784527
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28418299
53* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.28352953
54* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26227281
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24949059
56PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22790701
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21337655
58* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18129530
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16104220
60CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.15828537
61KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.15653391
62ZNF263_19887448_ChIP-Seq_K562_Human1.15557923
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14088874
64* KDM5A_27292631_Chip-Seq_BREAST_Human1.13592953
65FUS_26573619_Chip-Seq_HEK293_Human1.12451519
66MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07878061
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07537154
68* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07347100
69TAF15_26573619_Chip-Seq_HEK293_Human1.03663826
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01556139
71NANOG_16153702_ChIP-ChIP_HESCs_Human0.99723284
72BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98854140
73SOX17_20123909_ChIP-Seq_XEN_Mouse0.98442479
74SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95898926
75POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95055686
76ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92088511
77POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91320037
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91246537
79EWS_26573619_Chip-Seq_HEK293_Human0.90034631
80CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89039183
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.85315301
82NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.82953191
83SOX2_16153702_ChIP-ChIP_HESCs_Human0.82088270
84FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81571080
85* FOXP1_21924763_ChIP-Seq_HESCs_Human0.81183081
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80807772
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.79483802
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78237595
89RBPJ_22232070_ChIP-Seq_NCS_Mouse0.77994103
90SOX2_18555785_ChIP-Seq_MESCs_Mouse0.77889255
91* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77261420
92ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.75714973
93AR_21909140_ChIP-Seq_LNCAP_Human0.75016830
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.74392042
95ZFP57_27257070_Chip-Seq_ESCs_Mouse0.73206400
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73142412
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72811110
98EZH2_22144423_ChIP-Seq_EOC_Human0.72155891
99CBX2_27304074_Chip-Seq_ESCs_Mouse0.72072360
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.71516901
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.70819585
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.70144482
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69042466
104* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.68843924
105FLI1_27457419_Chip-Seq_LIVER_Mouse0.68312290
106CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.67897004
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.67737116
108* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67334282
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.67195064
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.67152524
111ELF5_23300383_ChIP-Seq_T47D_Human0.66919243
112CIITA_25753668_ChIP-Seq_RAJI_Human0.65717861
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.65604030
114* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.64608797
115OCT4_18692474_ChIP-Seq_MEFs_Mouse0.62338461
116CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.62042303
117STAT1_20625510_ChIP-Seq_HELA_Human0.61174286
118FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61020888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.19405922
2MP0001529_abnormal_vocalization3.87716603
3MP0003136_yellow_coat_color3.14033426
4MP0001905_abnormal_dopamine_level2.69870073
5MP0006036_abnormal_mitochondrial_physio2.46754820
6MP0003693_abnormal_embryo_hatching2.39677322
7MP0003880_abnormal_central_pattern2.38826813
8MP0004957_abnormal_blastocyst_morpholog2.37488205
9MP0002638_abnormal_pupillary_reflex2.26817925
10MP0003941_abnormal_skin_development2.22481594
11MP0006276_abnormal_autonomic_nervous2.19632210
12MP0006292_abnormal_olfactory_placode2.16924076
13MP0010030_abnormal_orbit_morphology2.12143512
14MP0003186_abnormal_redox_activity2.09999469
15MP0003806_abnormal_nucleotide_metabolis2.05628302
16MP0006035_abnormal_mitochondrial_morpho1.99065577
17MP0008932_abnormal_embryonic_tissue1.97122270
18MP0004142_abnormal_muscle_tone1.88839350
19MP0003718_maternal_effect1.87795029
20MP0002938_white_spotting1.81947426
21MP0000372_irregular_coat_pigmentation1.79520055
22MP0001293_anophthalmia1.79142035
23MP0001188_hyperpigmentation1.75437937
24MP0005084_abnormal_gallbladder_morpholo1.75351165
25MP0001986_abnormal_taste_sensitivity1.74629444
26MP0002102_abnormal_ear_morphology1.70643151
27MP0004147_increased_porphyrin_level1.63352414
28MP0000566_synostosis1.63148981
29MP0008057_abnormal_DNA_replication1.62291497
30MP0008007_abnormal_cellular_replicative1.61595977
31MP0001485_abnormal_pinna_reflex1.58127452
32MP0008058_abnormal_DNA_repair1.57329549
33MP0005409_darkened_coat_color1.57289703
34MP0002163_abnormal_gland_morphology1.53944537
35MP0001727_abnormal_embryo_implantation1.52638106
36MP0002160_abnormal_reproductive_system1.45556301
37MP0010094_abnormal_chromosome_stability1.45418743
38MP0004381_abnormal_hair_follicle1.44271649
39MP0009697_abnormal_copulation1.39950001
40MP0002653_abnormal_ependyma_morphology1.39519992
41MP0003077_abnormal_cell_cycle1.37679868
42MP0002837_dystrophic_cardiac_calcinosis1.36797909
43MP0008789_abnormal_olfactory_epithelium1.35248513
44MP0003315_abnormal_perineum_morphology1.31994078
45MP0005408_hypopigmentation1.31437559
46MP0004145_abnormal_muscle_electrophysio1.31215752
47MP0003786_premature_aging1.30883589
48MP0002277_abnormal_respiratory_mucosa1.29745435
49MP0003950_abnormal_plasma_membrane1.29648110
50MP0000749_muscle_degeneration1.23312468
51MP0002736_abnormal_nociception_after1.23114775
52MP0002132_abnormal_respiratory_system1.19859196
53MP0005171_absent_coat_pigmentation1.16494356
54MP0002210_abnormal_sex_determination1.15864837
55MP0006072_abnormal_retinal_apoptosis1.15074415
56MP0002751_abnormal_autonomic_nervous1.14964353
57MP0005423_abnormal_somatic_nervous1.14500945
58MP0003937_abnormal_limbs/digits/tail_de1.10628535
59MP0001968_abnormal_touch/_nociception1.09304370
60MP0000920_abnormal_myelination1.08627691
61MP0005389_reproductive_system_phenotype1.08472659
62MP0005174_abnormal_tail_pigmentation1.07788461
63MP0002272_abnormal_nervous_system1.05901181
64MP0004133_heterotaxia1.05094196
65MP0003011_delayed_dark_adaptation1.04783724
66MP0000350_abnormal_cell_proliferation1.01750039
67MP0000026_abnormal_inner_ear1.00587312
68MP0003121_genomic_imprinting0.98323474
69MP0003938_abnormal_ear_development0.97780009
70MP0005379_endocrine/exocrine_gland_phen0.96969445
71MP0005451_abnormal_body_composition0.96637390
72MP0003646_muscle_fatigue0.96504200
73MP0004742_abnormal_vestibular_system0.96431835
74MP0008875_abnormal_xenobiotic_pharmacok0.95276897
75MP0005075_abnormal_melanosome_morpholog0.94127329
76MP0003137_abnormal_impulse_conducting0.93228226
77MP0001286_abnormal_eye_development0.92829012
78MP0000049_abnormal_middle_ear0.92788735
79MP0001145_abnormal_male_reproductive0.92765995
80MP0000358_abnormal_cell_content/0.92544477
81MP0002735_abnormal_chemical_nociception0.90156758
82MP0004215_abnormal_myocardial_fiber0.89886895
83MP0002697_abnormal_eye_size0.89312088
84MP0002734_abnormal_mechanical_nocicepti0.88670147
85MP0002233_abnormal_nose_morphology0.88291827
86MP0001764_abnormal_homeostasis0.88287191
87MP0001919_abnormal_reproductive_system0.87852839
88MP0001963_abnormal_hearing_physiology0.87521218
89MP0001697_abnormal_embryo_size0.86779049
90MP0000653_abnormal_sex_gland0.86128052
91MP0009046_muscle_twitch0.85062119
92MP0000313_abnormal_cell_death0.84070332
93MP0005253_abnormal_eye_physiology0.83480209
94MP0001440_abnormal_grooming_behavior0.83089840
95MP0002148_abnormal_hypersensitivity_rea0.83079738
96MP0002090_abnormal_vision0.82909420
97MP0001929_abnormal_gametogenesis0.82652473
98MP0000750_abnormal_muscle_regeneration0.82651528
99MP0003111_abnormal_nucleus_morphology0.82384913
100MP0005646_abnormal_pituitary_gland0.81973828
101MP0002752_abnormal_somatic_nervous0.80931185
102MP0002234_abnormal_pharynx_morphology0.80496284
103MP0005266_abnormal_metabolism0.79942433
104MP0005645_abnormal_hypothalamus_physiol0.79493309
105MP0002095_abnormal_skin_pigmentation0.78601504
106MP0002085_abnormal_embryonic_tissue0.77460108
107MP0009333_abnormal_splenocyte_physiolog0.77441686
108MP0002876_abnormal_thyroid_physiology0.77312074
109MP0002332_abnormal_exercise_endurance0.76517981
110MP0001730_embryonic_growth_arrest0.76046963
111MP0002111_abnormal_tail_morphology0.75984832
112MP0005394_taste/olfaction_phenotype0.73320286
113MP0005499_abnormal_olfactory_system0.73320286
114MP0000631_abnormal_neuroendocrine_gland0.72856908
115MP0004019_abnormal_vitamin_homeostasis0.72835388
116MP0003123_paternal_imprinting0.72499841
117MP0008995_early_reproductive_senescence0.72054248
118MP0001970_abnormal_pain_threshold0.71541085
119MP0005410_abnormal_fertilization0.71217193
120MP0005332_abnormal_amino_acid0.70920442
121MP0003119_abnormal_digestive_system0.70066862
122MP0005551_abnormal_eye_electrophysiolog0.69861156
123MP0001881_abnormal_mammary_gland0.69768820
124MP0008877_abnormal_DNA_methylation0.68597250
125MP0001984_abnormal_olfaction0.68583867
126MP0000778_abnormal_nervous_system0.68430438
127MP0009250_abnormal_appendicular_skeleto0.67846144
128MP0009785_altered_susceptibility_to0.66326496
129MP0005636_abnormal_mineral_homeostasis0.65168514
130MP0000537_abnormal_urethra_morphology0.65135614
131MP0000647_abnormal_sebaceous_gland0.64839546
132MP0003221_abnormal_cardiomyocyte_apopto0.64470195
133MP0002106_abnormal_muscle_physiology0.64445838
134MP0003724_increased_susceptibility_to0.64035699
135MP0005376_homeostasis/metabolism_phenot0.63997947
136MP0005380_embryogenesis_phenotype0.63345065
137MP0001672_abnormal_embryogenesis/_devel0.63345065
138MP0003567_abnormal_fetal_cardiomyocyte0.63329928
139MP0000015_abnormal_ear_pigmentation0.63288897
140MP0003890_abnormal_embryonic-extraembry0.62912684
141MP0008872_abnormal_physiological_respon0.62774331
142MP0002177_abnormal_outer_ear0.62769312
143MP0005391_vision/eye_phenotype0.62194203

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.82758587
2Abnormal mitochondria in muscle tissue (HP:0008316)6.13738490
3Mitochondrial inheritance (HP:0001427)6.07843183
4Progressive macrocephaly (HP:0004481)5.61735193
5Acute encephalopathy (HP:0006846)5.55825505
6Increased hepatocellular lipid droplets (HP:0006565)5.41427893
7Abnormality of cells of the erythroid lineage (HP:0012130)5.22736980
8Increased CSF lactate (HP:0002490)5.20739040
9Hepatocellular necrosis (HP:0001404)5.12080776
10Lipid accumulation in hepatocytes (HP:0006561)4.79650652
11Renal Fanconi syndrome (HP:0001994)4.72269448
12Abnormal number of erythroid precursors (HP:0012131)4.68136544
13Hepatic necrosis (HP:0002605)4.48263327
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.45360049
153-Methylglutaconic aciduria (HP:0003535)4.33469306
16Abnormality of glycolysis (HP:0004366)4.30575852
17Increased serum pyruvate (HP:0003542)4.30575852
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.21452828
19Reticulocytopenia (HP:0001896)4.20538073
20Increased intramyocellular lipid droplets (HP:0012240)4.04554762
21Decreased activity of mitochondrial respiratory chain (HP:0008972)4.03928469
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.03928469
23Cerebral edema (HP:0002181)3.87378656
24Exercise intolerance (HP:0003546)3.86452716
25Exertional dyspnea (HP:0002875)3.77461193
26Macrocytic anemia (HP:0001972)3.71122224
27Increased serum lactate (HP:0002151)3.61883269
28Respiratory failure (HP:0002878)3.54926753
29Leukodystrophy (HP:0002415)3.52401591
30Optic disc pallor (HP:0000543)3.50114848
31Lactic acidosis (HP:0003128)3.41712657
32Increased muscle lipid content (HP:0009058)3.35910649
33Pallor (HP:0000980)3.25097591
34Respiratory difficulties (HP:0002880)3.24018314
35Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.14069191
36Parakeratosis (HP:0001036)3.13800666
37Abnormality of renal resorption (HP:0011038)3.09018146
38Microvesicular hepatic steatosis (HP:0001414)2.73337795
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.59311155
40Cerebral hypomyelination (HP:0006808)2.47572388
41Hyperglycinemia (HP:0002154)2.41553405
42Abnormality of urine glucose concentration (HP:0011016)2.28563750
43Glycosuria (HP:0003076)2.28563750
44CNS demyelination (HP:0007305)2.25654801
45Congenital ichthyosiform erythroderma (HP:0007431)2.24111456
46Hyperphosphaturia (HP:0003109)2.19325542
47Abnormality of the anterior horn cell (HP:0006802)2.18995462
48Degeneration of anterior horn cells (HP:0002398)2.18995462
49X-linked dominant inheritance (HP:0001423)2.18838757
50Emotional lability (HP:0000712)2.16769860
51Aplastic anemia (HP:0001915)2.15442007
52Abnormality of placental membranes (HP:0011409)2.12470542
53Amniotic constriction ring (HP:0009775)2.12470542
54Abnormality of serum amino acid levels (HP:0003112)2.07324101
55Microretrognathia (HP:0000308)2.06781362
56Colon cancer (HP:0003003)2.06444715
57Abnormality of alanine metabolism (HP:0010916)2.06045820
58Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06045820
59Type I transferrin isoform profile (HP:0003642)2.05756277
60Reduced antithrombin III activity (HP:0001976)2.05385891
61Cleft eyelid (HP:0000625)2.01318130
62Abnormality of methionine metabolism (HP:0010901)2.00998229
63Absent thumb (HP:0009777)2.00586241
64Testicular atrophy (HP:0000029)1.97692771
65Lethargy (HP:0001254)1.97023249
66Aplasia/hypoplasia of the uterus (HP:0008684)1.95259997
67Oral leukoplakia (HP:0002745)1.94161730
68Abnormal glycosylation (HP:0012345)1.93732284
69Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93732284
70Abnormal protein N-linked glycosylation (HP:0012347)1.93732284
71Abnormal protein glycosylation (HP:0012346)1.93732284
72Meckel diverticulum (HP:0002245)1.92857667
73Birth length less than 3rd percentile (HP:0003561)1.92582057
74Abnormality of secondary sexual hair (HP:0009888)1.91289111
75Abnormality of the axillary hair (HP:0100134)1.91289111
76Generalized aminoaciduria (HP:0002909)1.89951910
77Abnormal urine phosphate concentration (HP:0012599)1.88796214
78Megaloblastic anemia (HP:0001889)1.86934788
79Renal tubular dysfunction (HP:0000124)1.86862355
80Hypothermia (HP:0002045)1.86505759
81Abnormal hemoglobin (HP:0011902)1.85267472
82Stenosis of the external auditory canal (HP:0000402)1.82983742
83Abnormality of the ileum (HP:0001549)1.82239935
84Sclerocornea (HP:0000647)1.81165482
85Congenital, generalized hypertrichosis (HP:0004540)1.81037812
86Sparse eyelashes (HP:0000653)1.79056932
87Abnormal number of incisors (HP:0011064)1.77944757
88Partial duplication of thumb phalanx (HP:0009944)1.77635567
89Sensory axonal neuropathy (HP:0003390)1.76074983
90Pancreatic fibrosis (HP:0100732)1.75349540
91Muscle hypertrophy of the lower extremities (HP:0008968)1.73991001
92Blindness (HP:0000618)1.73425306
93Gout (HP:0001997)1.72392481
94Abnormality of the heme biosynthetic pathway (HP:0010472)1.70781741
95Abnormality of midbrain morphology (HP:0002418)1.69803372
96Molar tooth sign on MRI (HP:0002419)1.69803372
97Aplasia/Hypoplasia of the uvula (HP:0010293)1.69718036
98Myokymia (HP:0002411)1.68055273
99Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67590752
100Abnormality of the preputium (HP:0100587)1.66920948
101Breast hypoplasia (HP:0003187)1.66567521
102Horseshoe kidney (HP:0000085)1.66553155
103Dicarboxylic aciduria (HP:0003215)1.65967888
104Abnormality of dicarboxylic acid metabolism (HP:0010995)1.65967888
105Abnormality of the septum pellucidum (HP:0007375)1.64810730
106Hypoplastic pelvis (HP:0008839)1.63859698
107Abnormal pupillary function (HP:0007686)1.61399915
108Medial flaring of the eyebrow (HP:0010747)1.60945137
109Rough bone trabeculation (HP:0100670)1.60025960
110Pancytopenia (HP:0001876)1.59175582
111Progressive external ophthalmoplegia (HP:0000590)1.57758868
112Duplicated collecting system (HP:0000081)1.56235789
113Gliosis (HP:0002171)1.53392687
114Neuroendocrine neoplasm (HP:0100634)1.53127061
115Hypoplasia of the uterus (HP:0000013)1.52965231
116Absent septum pellucidum (HP:0001331)1.52945276
117Septo-optic dysplasia (HP:0100842)1.52616519
118Poor head control (HP:0002421)1.51854801
119Hypoplastic left heart (HP:0004383)1.49783023
120Partial duplication of the phalanx of hand (HP:0009999)1.49741530
121Nasolacrimal duct obstruction (HP:0000579)1.48405038
122Methylmalonic acidemia (HP:0002912)1.46726808
123Multiple enchondromatosis (HP:0005701)1.46611228
124CNS hypomyelination (HP:0003429)1.46050981
125Pancreatic cysts (HP:0001737)1.45731507
126Triphalangeal thumb (HP:0001199)1.45054355
127Methylmalonic aciduria (HP:0012120)1.44096288
128Duplication of thumb phalanx (HP:0009942)1.43052546
129Abnormal respiratory epithelium morphology (HP:0012253)1.42939793
130Abnormal respiratory motile cilium morphology (HP:0005938)1.42939793
131Calf muscle hypertrophy (HP:0008981)1.42757643
132Type 2 muscle fiber atrophy (HP:0003554)1.39647783
13311 pairs of ribs (HP:0000878)1.38092128
134Glossoptosis (HP:0000162)1.37533051
135Abnormality of the renal collecting system (HP:0004742)1.37269447
136Hyperalaninemia (HP:0003348)1.35860734

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.53442095
2NME23.89131053
3STK163.77539075
4BUB13.24396290
5PBK2.96262781
6EIF2AK12.88737590
7VRK12.85268457
8NME12.80169538
9STK392.46151786
10SRPK12.44652942
11MST42.31520599
12WEE12.29701947
13NEK12.24781421
14TLK12.03337293
15EIF2AK31.99887778
16MKNK11.83583354
17CASK1.82006742
18MAP3K121.66007872
19OXSR11.61470353
20BMPR1B1.57070941
21BCR1.56193955
22MUSK1.52213669
23PLK41.47895638
24LIMK11.47283851
25MYLK1.46180783
26ARAF1.44122822
27OBSCN1.43751349
28CDK191.43298759
29PNCK1.41517857
30PDK21.41406478
31PIM21.40731606
32DYRK21.39311191
33BLK1.31748982
34TAF11.30311127
35NUAK11.29112158
36ADRBK21.28443227
37GRK71.26628443
38WNK41.14596598
39EIF2AK21.10880436
40MAPKAPK51.09805994
41TRIM281.05663528
42CSNK1G31.04474743
43CHEK21.03749144
44ABL20.99753834
45AURKA0.98903038
46MKNK20.96505591
47CDC70.94136115
48YES10.89534896
49TNIK0.88847309
50STK40.86709878
51BMPR20.85038196
52IRAK40.84942837
53BRSK10.84145070
54BRAF0.83146764
55BRSK20.82390954
56TESK20.82374281
57UHMK10.81761160
58ACVR1B0.81114636
59TSSK60.80174280
60CDK80.79820017
61BCKDK0.78464954
62ATR0.78353816
63MAPK130.78315241
64CSNK2A10.76735272
65AURKB0.76330302
66CSNK2A20.75451539
67RPS6KA50.75357386
68ILK0.75223956
69MAP4K20.74521666
70ZAK0.74365617
71RPS6KA40.73362805
72PAK40.72625493
73KDR0.72476063
74PKN10.71247151
75PLK30.71113862
76DYRK30.70659346
77PLK10.70291100
78LRRK20.69637061
79MAP3K40.68210874
80CAMK2B0.68012990
81MAP2K70.66314795
82TESK10.66302022
83CLK10.65491199
84EPHB20.64241860
85RPS6KB20.62532790
86GRK50.61054397
87CCNB10.57580530
88PASK0.55847363
89DAPK10.51944734
90CSNK1G10.51840505
91PAK10.50595605
92CHEK10.49860394
93ADRBK10.49609373
94CSNK1E0.49359453
95PRKCG0.49322503
96ROCK20.46527615
97MARK10.45933308
98CAMK2D0.45820320
99NEK20.44547662
100PRKCI0.44241253
101CAMK2G0.42487389
102PLK20.41469274
103TTK0.41024981
104INSRR0.40952234
105MINK10.40862820
106FGR0.40766933
107ATM0.40685455
108CDK70.40124419
109CAMK2A0.39187322
110DMPK0.39123343
111PIK3CG0.37850057
112CSNK1A1L0.37836494
113CSNK1A10.37411489
114NEK60.37262349
115PRKACA0.37099711
116LYN0.37000096
117GRK10.36689569
118MAP2K60.35436786
119TEC0.33739938
120CDK140.33539140
121DAPK30.33162061
122CSNK1G20.31076299
123WNK30.30391951
124IRAK20.29665932
125TXK0.29561896
126IRAK30.28982698
127PRKCE0.28852448
128CDK11A0.28446426
129EPHA20.27842579
130MAP3K80.27322008
131PIM10.26041923
132CDK30.25319525

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.59832905
2Oxidative phosphorylation_Homo sapiens_hsa001905.10725053
3Parkinsons disease_Homo sapiens_hsa050124.43441194
4Proteasome_Homo sapiens_hsa030504.38289844
5RNA polymerase_Homo sapiens_hsa030203.43062111
6Huntingtons disease_Homo sapiens_hsa050163.27306350
7Alzheimers disease_Homo sapiens_hsa050103.24757481
8Protein export_Homo sapiens_hsa030603.04919909
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.78534797
10DNA replication_Homo sapiens_hsa030302.38210207
11Mismatch repair_Homo sapiens_hsa034302.30455196
12Spliceosome_Homo sapiens_hsa030402.22974395
13Pyrimidine metabolism_Homo sapiens_hsa002402.18008730
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09355151
15Cardiac muscle contraction_Homo sapiens_hsa042601.91945071
16Homologous recombination_Homo sapiens_hsa034401.85103237
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.84977242
18Nucleotide excision repair_Homo sapiens_hsa034201.80942673
19Fatty acid elongation_Homo sapiens_hsa000621.59842745
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46412066
21Basal transcription factors_Homo sapiens_hsa030221.39893519
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37950817
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34658028
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28258839
25Purine metabolism_Homo sapiens_hsa002301.26078077
26Base excision repair_Homo sapiens_hsa034101.25038753
27RNA transport_Homo sapiens_hsa030131.25020843
28RNA degradation_Homo sapiens_hsa030181.20938340
29Steroid biosynthesis_Homo sapiens_hsa001001.20213649
30Non-homologous end-joining_Homo sapiens_hsa034501.08084494
31Fanconi anemia pathway_Homo sapiens_hsa034601.01431154
32Glutathione metabolism_Homo sapiens_hsa004800.96534756
33Folate biosynthesis_Homo sapiens_hsa007900.93234606
34Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91418893
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.90765751
36Metabolic pathways_Homo sapiens_hsa011000.85211804
37Collecting duct acid secretion_Homo sapiens_hsa049660.80287867
38Arachidonic acid metabolism_Homo sapiens_hsa005900.78299493
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78071322
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71503195
41SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70917292
42One carbon pool by folate_Homo sapiens_hsa006700.69021493
43Sulfur metabolism_Homo sapiens_hsa009200.68521304
44Systemic lupus erythematosus_Homo sapiens_hsa053220.66992143
45Ether lipid metabolism_Homo sapiens_hsa005650.65729658
46Selenocompound metabolism_Homo sapiens_hsa004500.61646070
47Tyrosine metabolism_Homo sapiens_hsa003500.60978948
48Vibrio cholerae infection_Homo sapiens_hsa051100.56283472
49Linoleic acid metabolism_Homo sapiens_hsa005910.56092931
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52397454
51Arginine and proline metabolism_Homo sapiens_hsa003300.52143418
52Cell cycle_Homo sapiens_hsa041100.51979733
53Sulfur relay system_Homo sapiens_hsa041220.51306677
54Epstein-Barr virus infection_Homo sapiens_hsa051690.51211930
55Phenylalanine metabolism_Homo sapiens_hsa003600.50497139
56Pyruvate metabolism_Homo sapiens_hsa006200.50197192
57Propanoate metabolism_Homo sapiens_hsa006400.49362086
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.48240339
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.46170627
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45829826
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.44510925
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42763861
63Rheumatoid arthritis_Homo sapiens_hsa053230.42300457
64Histidine metabolism_Homo sapiens_hsa003400.42033300
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41212119
66Allograft rejection_Homo sapiens_hsa053300.41016883
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40859561
68Asthma_Homo sapiens_hsa053100.40261863
69Vitamin digestion and absorption_Homo sapiens_hsa049770.39948702
70Graft-versus-host disease_Homo sapiens_hsa053320.39304334
71Phototransduction_Homo sapiens_hsa047440.39096847
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38803209
73Carbon metabolism_Homo sapiens_hsa012000.37700350
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36814987
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.36021407
76Peroxisome_Homo sapiens_hsa041460.35564720
77Autoimmune thyroid disease_Homo sapiens_hsa053200.35420212
78Tryptophan metabolism_Homo sapiens_hsa003800.34664486
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34060327
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33207744
81Oocyte meiosis_Homo sapiens_hsa041140.32617626
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32469261
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31317848
84Vitamin B6 metabolism_Homo sapiens_hsa007500.30770308
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.30509688
86N-Glycan biosynthesis_Homo sapiens_hsa005100.30170220
87Alcoholism_Homo sapiens_hsa050340.29431503
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28491698
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.28325980
90Pentose phosphate pathway_Homo sapiens_hsa000300.27824467
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27335529
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27092656
93Phagosome_Homo sapiens_hsa041450.26905047
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.26499909
95Fatty acid degradation_Homo sapiens_hsa000710.26336770
96Serotonergic synapse_Homo sapiens_hsa047260.25895922
97Sphingolipid metabolism_Homo sapiens_hsa006000.25708680
98mRNA surveillance pathway_Homo sapiens_hsa030150.25362334
99Galactose metabolism_Homo sapiens_hsa000520.24516737
100Fatty acid metabolism_Homo sapiens_hsa012120.23271575
101Basal cell carcinoma_Homo sapiens_hsa052170.22306497
102Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20910137
103Chemical carcinogenesis_Homo sapiens_hsa052040.20111589
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.19446169
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17366454
106Butanoate metabolism_Homo sapiens_hsa006500.17143482
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.17077335
108Type I diabetes mellitus_Homo sapiens_hsa049400.15430370
109Hedgehog signaling pathway_Homo sapiens_hsa043400.15065657
110p53 signaling pathway_Homo sapiens_hsa041150.14914288
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14418957
112Fat digestion and absorption_Homo sapiens_hsa049750.14245262
113Caffeine metabolism_Homo sapiens_hsa002320.11337433
114Retinol metabolism_Homo sapiens_hsa008300.10865193
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.10609042
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10414856
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10167956
118Nitrogen metabolism_Homo sapiens_hsa009100.10056114
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09306197
120beta-Alanine metabolism_Homo sapiens_hsa004100.09096052
121Biosynthesis of amino acids_Homo sapiens_hsa012300.07953039
122Nicotine addiction_Homo sapiens_hsa050330.07481712
123Hematopoietic cell lineage_Homo sapiens_hsa046400.06880243
124Regulation of autophagy_Homo sapiens_hsa041400.06476440

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