CHAF1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.44503340
2protein localization to kinetochore (GO:0034501)5.04534735
3DNA strand elongation involved in DNA replication (GO:0006271)5.00950116
4DNA replication initiation (GO:0006270)4.92288477
5DNA strand elongation (GO:0022616)4.74800997
6protein localization to chromosome, centromeric region (GO:0071459)4.55881261
7telomere maintenance via semi-conservative replication (GO:0032201)4.52868285
8mitotic sister chromatid segregation (GO:0000070)4.48417684
9nuclear pore organization (GO:0006999)4.36967656
10DNA synthesis involved in DNA repair (GO:0000731)4.35656707
11nuclear pore complex assembly (GO:0051292)4.34055407
12mitotic nuclear envelope disassembly (GO:0007077)4.26450367
13DNA replication checkpoint (GO:0000076)4.26117343
14establishment of integrated proviral latency (GO:0075713)4.18869629
15sister chromatid segregation (GO:0000819)4.18593584
16mitotic chromosome condensation (GO:0007076)4.11037350
17telomere maintenance via recombination (GO:0000722)4.07768079
18mitotic metaphase plate congression (GO:0007080)3.98645701
19mitotic sister chromatid cohesion (GO:0007064)3.97914109
20regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.97105295
21nuclear envelope disassembly (GO:0051081)3.96683457
22membrane disassembly (GO:0030397)3.96683457
23mitotic recombination (GO:0006312)3.95226234
24DNA topological change (GO:0006265)3.94432210
25folic acid-containing compound biosynthetic process (GO:0009396)3.84913295
26heterochromatin organization (GO:0070828)3.84590127
27* DNA replication-dependent nucleosome organization (GO:0034723)3.82695870
28* DNA replication-dependent nucleosome assembly (GO:0006335)3.82695870
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.79136642
30DNA duplex unwinding (GO:0032508)3.76424285
31DNA geometric change (GO:0032392)3.75338493
32formation of translation preinitiation complex (GO:0001731)3.74552755
33kinetochore organization (GO:0051383)3.67990803
34nucleotide-excision repair, DNA gap filling (GO:0006297)3.63877899
35somatic diversification of immune receptors via somatic mutation (GO:0002566)3.60670496
36somatic hypermutation of immunoglobulin genes (GO:0016446)3.60670496
37ribosomal small subunit biogenesis (GO:0042274)3.60117665
38telomere maintenance via telomere lengthening (GO:0010833)3.56906920
39positive regulation of chromosome segregation (GO:0051984)3.51241568
40regulation of histone H3-K9 methylation (GO:0051570)3.50881827
41regulation of sister chromatid cohesion (GO:0007063)3.50267904
42metaphase plate congression (GO:0051310)3.48370315
43IMP biosynthetic process (GO:0006188)3.46230990
44protein complex localization (GO:0031503)3.44856364
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.44388350
46nucleobase biosynthetic process (GO:0046112)3.43750830
47chromatin remodeling at centromere (GO:0031055)3.41073324
48DNA replication-independent nucleosome assembly (GO:0006336)3.40153715
49DNA replication-independent nucleosome organization (GO:0034724)3.40153715
50chromosome condensation (GO:0030261)3.38809294
51DNA ligation (GO:0006266)3.36829906
52meiotic chromosome segregation (GO:0045132)3.36018395
53DNA conformation change (GO:0071103)3.35180741
54CENP-A containing nucleosome assembly (GO:0034080)3.31483088
55sister chromatid cohesion (GO:0007062)3.31450509
56pore complex assembly (GO:0046931)3.30586518
57protein localization to chromosome (GO:0034502)3.29341779
58* chromatin assembly or disassembly (GO:0006333)3.28798089
59regulation of spindle organization (GO:0090224)3.28774594
60negative regulation of mRNA metabolic process (GO:1903312)3.28577468
61translesion synthesis (GO:0019985)3.28122852
62regulation of chromosome segregation (GO:0051983)3.28022142
63attachment of spindle microtubules to kinetochore (GO:0008608)3.27742741
64regulation of centrosome cycle (GO:0046605)3.26409652
65establishment of chromosome localization (GO:0051303)3.25964007
66maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.22875510
67negative regulation of histone methylation (GO:0031061)3.21784093
68kinetochore assembly (GO:0051382)3.20586507
69L-serine metabolic process (GO:0006563)3.19820808
70histone exchange (GO:0043486)3.18728053
71non-recombinational repair (GO:0000726)3.18185558
72double-strand break repair via nonhomologous end joining (GO:0006303)3.18185558
73regulation of RNA export from nucleus (GO:0046831)3.16946912
74pre-miRNA processing (GO:0031054)3.15346931
75positive regulation of histone H3-K4 methylation (GO:0051571)3.14317580
76establishment of viral latency (GO:0019043)3.13465772
77chromosome segregation (GO:0007059)3.13313861
78chromosome organization involved in meiosis (GO:0070192)3.13149645
79nuclear envelope organization (GO:0006998)3.12958552
80DNA packaging (GO:0006323)3.12155769
81positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.12096595
82positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.12096595
83positive regulation of mitotic sister chromatid separation (GO:1901970)3.12096595
84dosage compensation (GO:0007549)3.09808153
85microtubule depolymerization (GO:0007019)3.08765109
86regulation of translational fidelity (GO:0006450)3.08745450
87negative regulation of RNA splicing (GO:0033119)3.08684382
88mismatch repair (GO:0006298)3.08599344
89negative regulation of chromosome segregation (GO:0051985)3.06995393
90IMP metabolic process (GO:0046040)3.05665509
91* DNA replication (GO:0006260)3.04822659
92telomere maintenance (GO:0000723)3.04146386
93telomere organization (GO:0032200)3.03738101
94regulation of DNA endoreduplication (GO:0032875)3.03108066
95chromosome organization (GO:0051276)3.02142355
96negative regulation of mRNA processing (GO:0050686)3.01208459
97base-excision repair (GO:0006284)3.00879789
98synapsis (GO:0007129)2.99738955
99postreplication repair (GO:0006301)2.99609440
100spindle checkpoint (GO:0031577)2.95627429
101regulation of sister chromatid segregation (GO:0033045)2.95119154
102regulation of mitotic sister chromatid separation (GO:0010965)2.95119154
103regulation of mitotic sister chromatid segregation (GO:0033047)2.95119154
104ATP-dependent chromatin remodeling (GO:0043044)2.94380413
105spliceosomal tri-snRNP complex assembly (GO:0000244)2.93990579
106regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93463417
107maturation of SSU-rRNA (GO:0030490)2.93353086
108DNA biosynthetic process (GO:0071897)2.92893712
109regulation of double-strand break repair via homologous recombination (GO:0010569)2.92641533
110regulation of centriole replication (GO:0046599)2.92277322
111protein K6-linked ubiquitination (GO:0085020)2.91945558
112negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91750197
113negative regulation of sister chromatid segregation (GO:0033046)2.91750197
114negative regulation of mitotic sister chromatid separation (GO:2000816)2.91750197
115negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91750197
116ribosome assembly (GO:0042255)2.91070305
117* chromatin assembly (GO:0031497)2.90617402
118ribosome biogenesis (GO:0042254)2.90600154
119regulation of posttranscriptional gene silencing (GO:0060147)2.89215714
120regulation of gene silencing by miRNA (GO:0060964)2.89215714
121regulation of gene silencing by RNA (GO:0060966)2.89215714
122spindle assembly checkpoint (GO:0071173)2.88733321
123regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88666147
124regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.87852679
125purine nucleobase biosynthetic process (GO:0009113)2.87222147
126negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.84539631

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.21230392
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.05963126
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.78045863
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.48002572
5* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.37674137
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.87415563
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78456145
8MYC_19030024_ChIP-ChIP_MESCs_Mouse2.53956151
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42441434
10AR_21909140_ChIP-Seq_LNCAP_Human2.41914009
11E2F1_21310950_ChIP-Seq_MCF-7_Human2.31891056
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.22781319
13MYC_22102868_ChIP-Seq_BL_Human2.17882779
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11003430
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.06870026
16XRN2_22483619_ChIP-Seq_HELA_Human2.04927792
17E2F7_22180533_ChIP-Seq_HELA_Human10.5086607
18ETS1_20019798_ChIP-Seq_JURKAT_Human1.97032239
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93346184
20CREB1_15753290_ChIP-ChIP_HEK293T_Human1.92955177
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91826401
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86907316
23MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82487851
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82473895
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.80377521
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72193951
27VDR_23849224_ChIP-Seq_CD4+_Human1.63952991
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63764382
29SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62619735
30FOXP3_21729870_ChIP-Seq_TREG_Human1.60732564
31* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59608028
32GABP_17652178_ChIP-ChIP_JURKAT_Human1.59322601
33GABP_19822575_ChIP-Seq_HepG2_Human1.57927617
34TTF2_22483619_ChIP-Seq_HELA_Human1.57778397
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55584860
36CIITA_25753668_ChIP-Seq_RAJI_Human1.52776203
37KDM5A_27292631_Chip-Seq_BREAST_Human1.49133028
38MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48452794
39DCP1A_22483619_ChIP-Seq_HELA_Human1.44731455
40TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.44381961
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.43077864
42VDR_21846776_ChIP-Seq_THP-1_Human1.42905627
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41624710
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39607615
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38431680
46* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.36644894
47DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.35921711
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35511376
49STAT3_1855785_ChIP-Seq_MESCs_Mouse1.35209335
50* TP63_19390658_ChIP-ChIP_HaCaT_Human1.33713827
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32539080
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32331803
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32065107
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30570820
55ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28616699
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.23642826
57CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.23226103
58SOX2_18555785_ChIP-Seq_MESCs_Mouse1.21325776
59E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19198709
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.19091432
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.18618529
62ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17018561
63* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15420616
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.14491297
65* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.14080965
66ELK1_19687146_ChIP-ChIP_HELA_Human1.08625441
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.08617858
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08590509
69* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05995729
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05834457
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05351266
72* TFEB_21752829_ChIP-Seq_HELA_Human1.03013838
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.00513102
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.00345457
75ESR1_15608294_ChIP-ChIP_MCF-7_Human0.99528082
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97975737
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96721229
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.96017651
79HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.95090957
80ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93371754
81PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.92336683
82* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88036470
83RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87787214
84PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87710510
85CHD1_26751641_Chip-Seq_LNCaP_Human0.87437193
86KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86555297
87KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86555297
88KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86555297
89TCF3_18692474_ChIP-Seq_MEFs_Mouse0.86091141
90KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.85980095
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85307461
92STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83440128
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83170020
94* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82890753
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82395554
96SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.81463789
97UTX_26944678_Chip-Seq_JUKART_Human0.80762029
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.80316349
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80155031
100TCF7_22412390_ChIP-Seq_EML_Mouse0.79097654
101NCOR1_26117541_ChIP-Seq_K562_Human0.78535074
102GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77172051
103TCF3_18692474_ChIP-Seq_MESCs_Mouse0.76843958
104SPI1_23547873_ChIP-Seq_NB4_Human0.76842756
105ZNF263_19887448_ChIP-Seq_K562_Human0.76279456
106* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.74937329
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74904029
108MYC_18940864_ChIP-ChIP_HL60_Human0.73553833
109FOXP1_21924763_ChIP-Seq_HESCs_Human0.72371475
110TET1_21451524_ChIP-Seq_MESCs_Mouse0.72108663
111E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.72061355
112* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71393094
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71247468
114* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.70970336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.61637393
2MP0003693_abnormal_embryo_hatching4.58430797
3* MP0003111_abnormal_nucleus_morphology4.32053377
4MP0008057_abnormal_DNA_replication4.18857442
5MP0004957_abnormal_blastocyst_morpholog3.92782910
6MP0003077_abnormal_cell_cycle3.83987626
7MP0008058_abnormal_DNA_repair2.82387418
8MP0010352_gastrointestinal_tract_polyps2.60831896
9MP0008877_abnormal_DNA_methylation2.48459455
10MP0008932_abnormal_embryonic_tissue2.46172260
11MP0008007_abnormal_cellular_replicative2.43210639
12* MP0001730_embryonic_growth_arrest2.42270543
13MP0010307_abnormal_tumor_latency2.40099147
14MP0000350_abnormal_cell_proliferation2.34621030
15MP0002396_abnormal_hematopoietic_system2.29083583
16MP0003123_paternal_imprinting2.25251545
17MP0005380_embryogenesis_phenotype1.95647867
18MP0001672_abnormal_embryogenesis/_devel1.95647867
19MP0001697_abnormal_embryo_size1.92548163
20MP0005076_abnormal_cell_differentiation1.87872211
21MP0002084_abnormal_developmental_patter1.81998720
22MP0002085_abnormal_embryonic_tissue1.79693237
23MP0010030_abnormal_orbit_morphology1.76771446
24MP0003984_embryonic_growth_retardation1.76100057
25MP0004185_abnormal_adipocyte_glucose1.75841223
26MP0002088_abnormal_embryonic_growth/wei1.72147970
27MP0009379_abnormal_foot_pigmentation1.71637140
28MP0004197_abnormal_fetal_growth/weight/1.70942812
29MP0003890_abnormal_embryonic-extraembry1.69562611
30MP0000490_abnormal_crypts_of1.69483654
31MP0002086_abnormal_extraembryonic_tissu1.66878330
32* MP0002080_prenatal_lethality1.66746837
33MP0003705_abnormal_hypodermis_morpholog1.66574380
34MP0003786_premature_aging1.58900649
35MP0004808_abnormal_hematopoietic_stem1.57410393
36MP0003121_genomic_imprinting1.56725922
37MP0009278_abnormal_bone_marrow1.54138865
38MP0005397_hematopoietic_system_phenotyp1.49441193
39MP0001545_abnormal_hematopoietic_system1.49441193
40MP0000313_abnormal_cell_death1.44460293
41MP0002210_abnormal_sex_determination1.43819675
42MP0002019_abnormal_tumor_incidence1.42706347
43MP0001929_abnormal_gametogenesis1.39693889
44MP0000537_abnormal_urethra_morphology1.34080867
45MP0003567_abnormal_fetal_cardiomyocyte1.33661881
46MP0000678_abnormal_parathyroid_gland1.32807089
47MP0002653_abnormal_ependyma_morphology1.31669850
48MP0001145_abnormal_male_reproductive1.29201697
49MP0005410_abnormal_fertilization1.25499702
50MP0000566_synostosis1.23044034
51MP0009697_abnormal_copulation1.22599365
52MP0001293_anophthalmia1.20334966
53MP0001346_abnormal_lacrimal_gland1.15116773
54MP0003119_abnormal_digestive_system1.13131815
55MP0003718_maternal_effect1.10312001
56MP0000653_abnormal_sex_gland1.09304950
57MP0001849_ear_inflammation1.05852727
58MP0000703_abnormal_thymus_morphology1.05137561
59MP0002249_abnormal_larynx_morphology1.03542314
60MP0003941_abnormal_skin_development1.03272135
61MP0009053_abnormal_anal_canal1.00117445
62MP0003937_abnormal_limbs/digits/tail_de0.98601802
63MP0004133_heterotaxia0.98340430
64MP0009333_abnormal_splenocyte_physiolog0.98340276
65MP0008995_early_reproductive_senescence0.98098167
66MP0001915_intracranial_hemorrhage0.96844689
67MP0009672_abnormal_birth_weight0.95287281
68MP0003698_abnormal_male_reproductive0.95198458
69MP0003566_abnormal_cell_adhesion0.94991030
70MP0000049_abnormal_middle_ear0.92923900
71MP0002398_abnormal_bone_marrow0.91675602
72MP0009703_decreased_birth_body0.89740757
73MP0002111_abnormal_tail_morphology0.88978431
74MP0002722_abnormal_immune_system0.87808463
75MP0005023_abnormal_wound_healing0.87744251
76MP0000428_abnormal_craniofacial_morphol0.84991924
77MP0003136_yellow_coat_color0.84857540
78MP0004233_abnormal_muscle_weight0.84124160
79MP0006035_abnormal_mitochondrial_morpho0.82707929
80MP0005621_abnormal_cell_physiology0.82352687
81MP0006054_spinal_hemorrhage0.81607479
82MP0005384_cellular_phenotype0.81549075
83MP0000689_abnormal_spleen_morphology0.80467254
84MP0003763_abnormal_thymus_physiology0.79711695
85MP0002092_abnormal_eye_morphology0.77191803
86MP0003315_abnormal_perineum_morphology0.77069357
87MP0003943_abnormal_hepatobiliary_system0.75906536
88MP0002160_abnormal_reproductive_system0.75639335
89MP0002161_abnormal_fertility/fecundity0.75180585
90MP0000358_abnormal_cell_content/0.75119156
91MP0003115_abnormal_respiratory_system0.74483423
92MP0002796_impaired_skin_barrier0.74245103
93MP0000432_abnormal_head_morphology0.74232316
94MP0001661_extended_life_span0.73864677
95MP0000733_abnormal_muscle_development0.73735304
96MP0002697_abnormal_eye_size0.73106725
97MP0004264_abnormal_extraembryonic_tissu0.72722001
98MP0002925_abnormal_cardiovascular_devel0.72281147
99MP0002089_abnormal_postnatal_growth/wei0.71631385
100MP0005451_abnormal_body_composition0.71443330
101MP0001119_abnormal_female_reproductive0.70789545
102MP0000858_altered_metastatic_potential0.70216919
103MP0003935_abnormal_craniofacial_develop0.66496263
104MP0008770_decreased_survivor_rate0.65969328
105MP0000477_abnormal_intestine_morphology0.65553182
106MP0002233_abnormal_nose_morphology0.65176972
107MP0002429_abnormal_blood_cell0.64784774
108MP0002282_abnormal_trachea_morphology0.62895536
109MP0003861_abnormal_nervous_system0.62471906
110MP0002009_preneoplasia0.62080198
111MP0005499_abnormal_olfactory_system0.61880949
112MP0005394_taste/olfaction_phenotype0.61880949
113MP0008789_abnormal_olfactory_epithelium0.61358132
114MP0002163_abnormal_gland_morphology0.59570473
115MP0002114_abnormal_axial_skeleton0.59035386
116MP0005501_abnormal_skin_physiology0.58092871
117MP0000762_abnormal_tongue_morphology0.57963173
118MP0001881_abnormal_mammary_gland0.57281889
119MP0002932_abnormal_joint_morphology0.56994283
120MP0003699_abnormal_female_reproductive0.56557157
121MP0006292_abnormal_olfactory_placode0.56510148
122MP0003221_abnormal_cardiomyocyte_apopto0.56184133
123MP0005389_reproductive_system_phenotype0.56017901
124MP0005666_abnormal_adipose_tissue0.56009669
125MP0002877_abnormal_melanocyte_morpholog0.55786260
126MP0001286_abnormal_eye_development0.55744030

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.54645528
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.45848333
3Birth length less than 3rd percentile (HP:0003561)4.02929926
4Medulloblastoma (HP:0002885)3.97476675
5Selective tooth agenesis (HP:0001592)3.68263948
6Ependymoma (HP:0002888)3.62440124
7Abnormality of chromosome stability (HP:0003220)3.43549292
8Meckel diverticulum (HP:0002245)3.27068859
9Abnormality of the ileum (HP:0001549)3.26396206
10Aplasia/Hypoplasia of the uvula (HP:0010293)3.19989390
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.14915563
12Abnormality of the preputium (HP:0100587)3.12794083
13Breast hypoplasia (HP:0003187)3.11215952
14Patellar aplasia (HP:0006443)3.10431290
15Colon cancer (HP:0003003)3.04306741
16Abnormality of cochlea (HP:0000375)3.00891480
17Impulsivity (HP:0100710)2.94032529
18Aplasia/Hypoplasia of the patella (HP:0006498)2.87490848
19Reticulocytopenia (HP:0001896)2.86863408
20Increased nuchal translucency (HP:0010880)2.83919368
21Duplication of thumb phalanx (HP:0009942)2.83585455
22Small intestinal stenosis (HP:0012848)2.81783760
23Duodenal stenosis (HP:0100867)2.81783760
24Ectopic kidney (HP:0000086)2.78321662
25Myelodysplasia (HP:0002863)2.74681021
26High anterior hairline (HP:0009890)2.73986155
27Progressive muscle weakness (HP:0003323)2.71813396
28Agnosia (HP:0010524)2.69910346
29Rhabdomyosarcoma (HP:0002859)2.69193110
30Volvulus (HP:0002580)2.67680391
31Aplastic anemia (HP:0001915)2.67170963
32Short 4th metacarpal (HP:0010044)2.66923712
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.66923712
34Absent thumb (HP:0009777)2.63448475
35Astrocytoma (HP:0009592)2.60002358
36Abnormality of the astrocytes (HP:0100707)2.60002358
37Basal cell carcinoma (HP:0002671)2.59341512
38Microvesicular hepatic steatosis (HP:0001414)2.58209594
39Abnormality of the labia minora (HP:0012880)2.55175263
40Abnormality of the anterior horn cell (HP:0006802)2.54592447
41Degeneration of anterior horn cells (HP:0002398)2.54592447
42Abnormality of the carotid arteries (HP:0005344)2.52053399
43Absent radius (HP:0003974)2.48541691
44Facial hemangioma (HP:0000329)2.48466760
45Proximal placement of thumb (HP:0009623)2.46734627
46Abnormal number of incisors (HP:0011064)2.44889622
47Deviation of the thumb (HP:0009603)2.43544226
48Nephroblastoma (Wilms tumor) (HP:0002667)2.43136309
49Abnormality of cells of the erythroid lineage (HP:0012130)2.43028145
50Broad distal phalanx of finger (HP:0009836)2.34966358
51Sloping forehead (HP:0000340)2.34351768
52Neoplasm of the oral cavity (HP:0100649)2.34094322
53Cafe-au-lait spot (HP:0000957)2.33565974
54Short thumb (HP:0009778)2.33198091
55Squamous cell carcinoma (HP:0002860)2.32547359
56Abnormality of the duodenum (HP:0002246)2.31756374
57Neoplasm of striated muscle (HP:0009728)2.31501327
58Aplasia involving forearm bones (HP:0009822)2.30984402
59Absent forearm bone (HP:0003953)2.30984402
60Supernumerary spleens (HP:0009799)2.30220425
61High pitched voice (HP:0001620)2.29929344
62Abnormal number of erythroid precursors (HP:0012131)2.29207947
63Carpal bone hypoplasia (HP:0001498)2.28672696
64Abnormality of DNA repair (HP:0003254)2.26513722
65Embryonal renal neoplasm (HP:0011794)2.25482831
66Oral leukoplakia (HP:0002745)2.25141474
67Rib fusion (HP:0000902)2.24678719
68Atresia of the external auditory canal (HP:0000413)2.23917560
69Abnormal lung lobation (HP:0002101)2.22973150
70Facial cleft (HP:0002006)2.20168005
71Glioma (HP:0009733)2.19889869
72Prominent nose (HP:0000448)2.19107716
73Tracheoesophageal fistula (HP:0002575)2.17121983
74Intestinal fistula (HP:0100819)2.16329154
75Morphological abnormality of the inner ear (HP:0011390)2.15469929
76Neoplasm of the pancreas (HP:0002894)2.13525834
77Urethral obstruction (HP:0000796)2.12156327
78Acute lymphatic leukemia (HP:0006721)2.11748025
79Overlapping toe (HP:0001845)2.10578405
80Progressive external ophthalmoplegia (HP:0000590)2.08894944
81Missing ribs (HP:0000921)2.07616896
82Aplasia/hypoplasia of the humerus (HP:0006507)2.06756131
83Bone marrow hypocellularity (HP:0005528)2.05479383
84Abnormality of reticulocytes (HP:0004312)2.04510038
85Choanal atresia (HP:0000453)2.04498001
86Rough bone trabeculation (HP:0100670)2.03506189
8711 pairs of ribs (HP:0000878)2.03253692
88Abnormality of homocysteine metabolism (HP:0010919)2.02762615
89Homocystinuria (HP:0002156)2.02762615
90Hypoplasia of the capital femoral epiphysis (HP:0003090)2.02337317
91Clubbing of toes (HP:0100760)2.02098636
92Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.01353728
93Arteriovenous malformation (HP:0100026)2.00172264
94Embryonal neoplasm (HP:0002898)1.96368367
95Pallor (HP:0000980)1.94941239
96Short humerus (HP:0005792)1.94231984
97Macrocytic anemia (HP:0001972)1.94193131
98Overriding aorta (HP:0002623)1.94106613
99Rectovaginal fistula (HP:0000143)1.93812583
100Rectal fistula (HP:0100590)1.93812583
101Abnormality of chromosome segregation (HP:0002916)1.93617377
102Aplasia/Hypoplasia of the sternum (HP:0006714)1.91258563
103Abdominal situs inversus (HP:0003363)1.85112785
104Abnormality of abdominal situs (HP:0011620)1.85112785
105Abnormality of the renal collecting system (HP:0004742)1.84570966
106Premature graying of hair (HP:0002216)1.84071338
107Premature ovarian failure (HP:0008209)1.83954388
108Capillary hemangiomas (HP:0005306)1.83498548
109Horseshoe kidney (HP:0000085)1.83369358
110Partial duplication of thumb phalanx (HP:0009944)1.82913619
111Abnormality of the 4th metacarpal (HP:0010012)1.82775836
112Duplicated collecting system (HP:0000081)1.82589292
113Poikiloderma (HP:0001029)1.80825389
114Renal duplication (HP:0000075)1.80616481
115Slender long bone (HP:0003100)1.80518566
116Triphalangeal thumb (HP:0001199)1.79530137
117Long eyelashes (HP:0000527)1.78454234
118Hyperacusis (HP:0010780)1.78219512
119Vaginal fistula (HP:0004320)1.77536401
120Insomnia (HP:0100785)1.77166380
121Microtia (HP:0008551)1.76919327
122Spastic diplegia (HP:0001264)1.76619524
123Cleft eyelid (HP:0000625)1.75640953
124Trismus (HP:0000211)1.73767996
125Cortical dysplasia (HP:0002539)1.73613383
126Amaurosis fugax (HP:0100576)1.72853429
127Abnormality of the calcaneus (HP:0008364)1.71046226
128Ulnar bowing (HP:0003031)1.71039856
129Biliary tract neoplasm (HP:0100574)1.69440212
130Abnormality of the fingertips (HP:0001211)1.68475597
131Abnormality of the salivary glands (HP:0010286)1.68213524
132Skin tags (HP:0010609)1.68075942
133Gastrointestinal carcinoma (HP:0002672)1.67566693
134Malignant gastrointestinal tract tumors (HP:0006749)1.67566693
135Deep palmar crease (HP:0006191)1.67180060
136Hypergonadotropic hypogonadism (HP:0000815)1.67124283
137Multiple enchondromatosis (HP:0005701)1.65907903
138Asplenia (HP:0001746)1.64418020

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.27546233
2NEK23.51002885
3WEE13.40415457
4BUB13.32276810
5SMG13.22153266
6CDK123.18072521
7EEF2K2.85682618
8VRK22.67965251
9TTK2.61220475
10MAP3K102.21271110
11PASK2.12880445
12CDK72.08288690
13NEK12.02215207
14ATR1.89629142
15PLK11.88268744
16PKN21.85788476
17CHEK21.80947589
18CDK41.77964359
19PLK41.76163085
20PNCK1.76122129
21TAF11.74920843
22SRPK11.71517602
23RPS6KB21.71250137
24AURKB1.68150754
25TESK21.65259811
26STK101.64508481
27ICK1.56922037
28EIF2AK11.53243760
29CHEK11.50559848
30BRSK21.50428952
31MAP3K81.49833524
32ACVR1B1.47523404
33TSSK61.47463495
34MKNK11.41479950
35CAMK1G1.39452494
36PBK1.37438655
37TESK11.34995421
38PAK41.29967803
39STK41.24563631
40DYRK31.22754010
41SCYL21.21159603
42RPS6KA41.19793358
43TRIB31.17084717
44AURKA1.16150602
45ZAK1.15202732
46ATM1.11111458
47BRSK11.10374751
48PLK31.08953122
49BRD41.08650026
50CDK21.04809134
51CDK61.03504803
52STK31.03180143
53NME21.02803580
54CAMK1D1.01421620
55IRAK30.99779668
56MTOR0.96911236
57PIM10.96770319
58EPHA20.90983768
59PDK30.89916641
60PDK40.89916641
61VRK10.89765557
62MKNK20.89017877
63CDK80.89011362
64PRPF4B0.88207847
65CDK190.88144876
66TGFBR10.86090883
67TLK10.85725908
68ALK0.85386902
69LATS20.82911434
70MAP4K10.80382396
71MET0.79071024
72EIF2AK30.76415158
73LATS10.75474258
74CDK10.75273732
75STK160.75011133
76ARAF0.74024906
77MELK0.73261095
78NME10.72670401
79LRRK20.72503695
80MAP3K90.72392983
81CCNB10.71382436
82PAK10.70654684
83FLT30.69190936
84TRIM280.62975311
85PRKD30.61754081
86MAP3K60.60352551
87MAP2K30.58440138
88CSNK2A20.58360114
89BMX0.56323092
90TTN0.56011319
91MAP3K110.54618921
92PAK20.54244350
93CDK11A0.53928712
94CSNK2A10.51876993
95EIF2AK20.50839207
96MAP3K130.49496890
97MAPKAPK30.46146092
98MAPK110.45947186
99AKT20.45834396
100CSNK1E0.44107002
101PRKDC0.42959613
102CLK10.40818954
103PDGFRA0.40780570
104PDK20.40427247
105CDK150.40054199
106MAPK140.39989831
107GRK60.38377123
108BTK0.38212053
109TAOK20.36633916
110TYRO30.36621864
111MST1R0.35541279
112RAF10.35436385
113CDK30.35324290
114CSNK1D0.34948158
115PRKCI0.33965952
116CDK180.33647541
117AKT10.33472748
118MATK0.33232566
119RPS6KA10.33154215
120DYRK1B0.32360191
121DAPK10.30769772
122STK240.30058003
123BRAF0.28444122
124MAPK10.28114183
125GSK3B0.27118449
126CSF1R0.26149676
127CDK90.25849441
128KDR0.25426454
129STK38L0.25170979

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.42146099
2Mismatch repair_Homo sapiens_hsa034304.60510588
3Base excision repair_Homo sapiens_hsa034103.30010027
4Spliceosome_Homo sapiens_hsa030403.26607048
5RNA transport_Homo sapiens_hsa030133.24538238
6Cell cycle_Homo sapiens_hsa041103.21621212
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16348680
8Homologous recombination_Homo sapiens_hsa034402.99342981
9Nucleotide excision repair_Homo sapiens_hsa034202.78530883
10One carbon pool by folate_Homo sapiens_hsa006702.70039585
11Fanconi anemia pathway_Homo sapiens_hsa034602.62090855
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13759750
13mRNA surveillance pathway_Homo sapiens_hsa030152.12496008
14Ribosome_Homo sapiens_hsa030102.10127481
15RNA polymerase_Homo sapiens_hsa030202.03402828
16Non-homologous end-joining_Homo sapiens_hsa034501.99173089
17Pyrimidine metabolism_Homo sapiens_hsa002401.95044333
18RNA degradation_Homo sapiens_hsa030181.86821228
19Basal transcription factors_Homo sapiens_hsa030221.83113746
20Proteasome_Homo sapiens_hsa030501.76280007
21p53 signaling pathway_Homo sapiens_hsa041151.73844603
22Systemic lupus erythematosus_Homo sapiens_hsa053221.30210859
23Viral carcinogenesis_Homo sapiens_hsa052031.22565986
24Oocyte meiosis_Homo sapiens_hsa041141.18812552
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12869417
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.09642918
27MicroRNAs in cancer_Homo sapiens_hsa052061.08522017
28Epstein-Barr virus infection_Homo sapiens_hsa051691.07830021
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07218339
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00527553
31HTLV-I infection_Homo sapiens_hsa051660.97715740
32Small cell lung cancer_Homo sapiens_hsa052220.95956599
33Herpes simplex infection_Homo sapiens_hsa051680.95769893
34Antigen processing and presentation_Homo sapiens_hsa046120.95167216
35Purine metabolism_Homo sapiens_hsa002300.92922254
36Biosynthesis of amino acids_Homo sapiens_hsa012300.91914766
37Selenocompound metabolism_Homo sapiens_hsa004500.84152692
38Thyroid cancer_Homo sapiens_hsa052160.81630903
39Chronic myeloid leukemia_Homo sapiens_hsa052200.81352451
40Basal cell carcinoma_Homo sapiens_hsa052170.78742393
41Pentose phosphate pathway_Homo sapiens_hsa000300.77427778
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.76219395
43Pyruvate metabolism_Homo sapiens_hsa006200.76056953
44Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75250744
45Colorectal cancer_Homo sapiens_hsa052100.73806745
46Bladder cancer_Homo sapiens_hsa052190.73086617
47Hippo signaling pathway_Homo sapiens_hsa043900.72781834
48Notch signaling pathway_Homo sapiens_hsa043300.72544291
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71046810
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64253171
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.63332179
52TGF-beta signaling pathway_Homo sapiens_hsa043500.61651125
53Lysine degradation_Homo sapiens_hsa003100.61647189
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61598476
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59555803
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59286464
57Adherens junction_Homo sapiens_hsa045200.58808442
58Vitamin B6 metabolism_Homo sapiens_hsa007500.58150705
59mTOR signaling pathway_Homo sapiens_hsa041500.57732068
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57719728
61Hedgehog signaling pathway_Homo sapiens_hsa043400.57592727
62Non-small cell lung cancer_Homo sapiens_hsa052230.55480159
63Apoptosis_Homo sapiens_hsa042100.54611649
64Hepatitis B_Homo sapiens_hsa051610.53950487
65Huntingtons disease_Homo sapiens_hsa050160.53322118
66Shigellosis_Homo sapiens_hsa051310.51612064
67Legionellosis_Homo sapiens_hsa051340.50955232
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.50938361
69Cyanoamino acid metabolism_Homo sapiens_hsa004600.50423414
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49980653
71Pancreatic cancer_Homo sapiens_hsa052120.46224588
72Alcoholism_Homo sapiens_hsa050340.45885800
73Prostate cancer_Homo sapiens_hsa052150.42860469
74HIF-1 signaling pathway_Homo sapiens_hsa040660.42463555
75Pathways in cancer_Homo sapiens_hsa052000.42454192
76Acute myeloid leukemia_Homo sapiens_hsa052210.42135151
77Sulfur relay system_Homo sapiens_hsa041220.41194679
78Viral myocarditis_Homo sapiens_hsa054160.40864263
79Primary immunodeficiency_Homo sapiens_hsa053400.40084494
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39116090
81Measles_Homo sapiens_hsa051620.36843536
82Galactose metabolism_Homo sapiens_hsa000520.35626510
83N-Glycan biosynthesis_Homo sapiens_hsa005100.34993464
84Proteoglycans in cancer_Homo sapiens_hsa052050.34890997
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34021318
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.33708906
87Carbon metabolism_Homo sapiens_hsa012000.33486821
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.33086136
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.33076788
90Folate biosynthesis_Homo sapiens_hsa007900.32550553
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32527198
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32380996
93Endometrial cancer_Homo sapiens_hsa052130.32158835
94Wnt signaling pathway_Homo sapiens_hsa043100.32002085
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31034913
96Fructose and mannose metabolism_Homo sapiens_hsa000510.30388976
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30289317
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29871404
99Glutathione metabolism_Homo sapiens_hsa004800.29003442
100Glioma_Homo sapiens_hsa052140.28178756
101Melanoma_Homo sapiens_hsa052180.27651681
102VEGF signaling pathway_Homo sapiens_hsa043700.25709052
103Renin-angiotensin system_Homo sapiens_hsa046140.25552842
104B cell receptor signaling pathway_Homo sapiens_hsa046620.24903727
105Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.24619352
106Influenza A_Homo sapiens_hsa051640.23842639
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22897554
108Tight junction_Homo sapiens_hsa045300.22203089
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.21435858
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21384573
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20974576
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20957513
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19371494
114Metabolic pathways_Homo sapiens_hsa011000.16786915
115Arginine biosynthesis_Homo sapiens_hsa002200.16491384
116ErbB signaling pathway_Homo sapiens_hsa040120.16370478
117Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.16199802
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.15887056
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.15868007
120AMPK signaling pathway_Homo sapiens_hsa041520.14767619
121Parkinsons disease_Homo sapiens_hsa050120.13849663
122Arginine and proline metabolism_Homo sapiens_hsa003300.13653632
123Insulin signaling pathway_Homo sapiens_hsa049100.13465215

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