CHAC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.64266067
2L-phenylalanine catabolic process (GO:0006559)6.64266067
3L-phenylalanine metabolic process (GO:0006558)6.12874901
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.12874901
5aromatic amino acid family catabolic process (GO:0009074)5.77061503
6indole-containing compound catabolic process (GO:0042436)5.01384715
7indolalkylamine catabolic process (GO:0046218)5.01384715
8tryptophan catabolic process (GO:0006569)5.01384715
9cellular ketone body metabolic process (GO:0046950)4.96899333
10proteasome assembly (GO:0043248)4.93973572
11bile acid biosynthetic process (GO:0006699)4.87975832
12glyoxylate metabolic process (GO:0046487)4.67563116
13mitotic metaphase plate congression (GO:0007080)4.67214753
14tryptophan metabolic process (GO:0006568)4.65205331
15kynurenine metabolic process (GO:0070189)4.60656210
16establishment of integrated proviral latency (GO:0075713)4.56920051
17ribosome assembly (GO:0042255)4.54921831
18aldehyde catabolic process (GO:0046185)4.54589810
19cysteine metabolic process (GO:0006534)4.48820775
20DNA strand elongation involved in DNA replication (GO:0006271)4.48344454
21CENP-A containing nucleosome assembly (GO:0034080)4.44036261
22cofactor catabolic process (GO:0051187)4.41342118
23chaperone-mediated protein transport (GO:0072321)4.40588865
24chromatin remodeling at centromere (GO:0031055)4.39737009
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.38633478
26triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.37818927
27telomere maintenance via semi-conservative replication (GO:0032201)4.36690066
28DNA replication checkpoint (GO:0000076)4.31625370
29DNA strand elongation (GO:0022616)4.30893313
30ketone body metabolic process (GO:1902224)4.30355484
31coenzyme catabolic process (GO:0009109)4.27375537
32negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.26646625
33aromatic amino acid family metabolic process (GO:0009072)4.13287720
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.10962384
35purine nucleobase biosynthetic process (GO:0009113)4.02779450
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.02028563
37sulfur amino acid catabolic process (GO:0000098)4.00970157
38protein localization to kinetochore (GO:0034501)3.98817755
39high-density lipoprotein particle remodeling (GO:0034375)3.98583760
40regulation of mitochondrial translation (GO:0070129)3.98234598
41bile acid metabolic process (GO:0008206)3.97943884
42protoporphyrinogen IX metabolic process (GO:0046501)3.96279697
43protein carboxylation (GO:0018214)3.96257719
44peptidyl-glutamic acid carboxylation (GO:0017187)3.96257719
45tyrosine metabolic process (GO:0006570)3.95326050
46positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.93628984
47negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.89747487
48negative regulation of ligase activity (GO:0051352)3.89747487
49protoporphyrinogen IX biosynthetic process (GO:0006782)3.88462205
50metaphase plate congression (GO:0051310)3.87974078
51regulation of fibrinolysis (GO:0051917)3.87193916
52urea metabolic process (GO:0019627)3.85770378
53urea cycle (GO:0000050)3.85770378
54indolalkylamine metabolic process (GO:0006586)3.83131711
55nucleobase biosynthetic process (GO:0046112)3.81557863
56regulation of protein activation cascade (GO:2000257)3.80453514
57lysine metabolic process (GO:0006553)3.77062790
58lysine catabolic process (GO:0006554)3.77062790
59pseudouridine synthesis (GO:0001522)3.76790853
60rRNA modification (GO:0000154)3.76170087
61amine catabolic process (GO:0009310)3.76086856
62cellular biogenic amine catabolic process (GO:0042402)3.76086856
63regulation of cholesterol esterification (GO:0010872)3.75402183
64telomere maintenance via recombination (GO:0000722)3.74720407
65mitotic sister chromatid segregation (GO:0000070)3.69217291
66negative regulation of fibrinolysis (GO:0051918)3.68590804
67nitrogen cycle metabolic process (GO:0071941)3.68513479
68IMP biosynthetic process (GO:0006188)3.67890141
69alpha-linolenic acid metabolic process (GO:0036109)3.67832034
70alpha-amino acid catabolic process (GO:1901606)3.67774202
71histone exchange (GO:0043486)3.66348204
72fatty acid elongation (GO:0030497)3.64939607
73fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.64375321
74folic acid-containing compound biosynthetic process (GO:0009396)3.63197727
75mitotic recombination (GO:0006312)3.61908555
76complement activation, alternative pathway (GO:0006957)3.60023583
77spliceosomal snRNP assembly (GO:0000387)3.58332012
78maturation of 5.8S rRNA (GO:0000460)3.56963248
79cullin deneddylation (GO:0010388)3.56572997
80glutamate metabolic process (GO:0006536)3.55795777
81regulation of complement activation (GO:0030449)3.54768871
82opsonization (GO:0008228)3.53494077
83nucleotide-excision repair, DNA gap filling (GO:0006297)3.53422239
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52553842
85spindle checkpoint (GO:0031577)3.52236693
86DNA replication-independent nucleosome assembly (GO:0006336)3.51577577
87DNA replication-independent nucleosome organization (GO:0034724)3.51577577
88cellular glucuronidation (GO:0052695)3.50730477
89short-chain fatty acid metabolic process (GO:0046459)3.49977930
90protein targeting to mitochondrion (GO:0006626)3.49880528
91ribosomal large subunit biogenesis (GO:0042273)3.49239008
92respiratory chain complex IV assembly (GO:0008535)3.49195240
93protein localization to chromosome, centromeric region (GO:0071459)3.48651404
94uronic acid metabolic process (GO:0006063)3.48455857
95glucuronate metabolic process (GO:0019585)3.48455857
96establishment of viral latency (GO:0019043)3.48030705
97rRNA processing (GO:0006364)3.46134424
98pteridine-containing compound biosynthetic process (GO:0042559)3.45545307
99benzene-containing compound metabolic process (GO:0042537)3.44070138
100cellular amino acid catabolic process (GO:0009063)3.43564835
101ribosome biogenesis (GO:0042254)3.42685123
102alkaloid metabolic process (GO:0009820)3.42321932
103transcription elongation from RNA polymerase III promoter (GO:0006385)3.42161697
104termination of RNA polymerase III transcription (GO:0006386)3.42161697
105kinetochore organization (GO:0051383)3.41342654
106exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41085610
107nucleobase-containing small molecule interconversion (GO:0015949)3.40817657
108DNA ligation (GO:0006266)3.40557931
109protein-lipid complex remodeling (GO:0034368)3.39830518
110macromolecular complex remodeling (GO:0034367)3.39830518
111plasma lipoprotein particle remodeling (GO:0034369)3.39830518
112mitotic spindle checkpoint (GO:0071174)3.37257903
113positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.36786132
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36652023
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36652023
116negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36652023
117negative regulation of mitotic sister chromatid separation (GO:2000816)3.36652023
118negative regulation of sister chromatid segregation (GO:0033046)3.36652023
119acetyl-CoA metabolic process (GO:0006084)3.35361214
120protein neddylation (GO:0045116)3.34931478
121heme transport (GO:0015886)3.34809989
122sister chromatid segregation (GO:0000819)3.34245170
123deoxyribonucleotide biosynthetic process (GO:0009263)3.34077566
124negative regulation of chromosome segregation (GO:0051985)3.33611582
125aspartate family amino acid catabolic process (GO:0009068)3.33013166
126rRNA metabolic process (GO:0016072)3.32469816
127ribonucleoprotein complex biogenesis (GO:0022613)3.32256477
128cholesterol efflux (GO:0033344)3.32202926
129regulation of triglyceride catabolic process (GO:0010896)3.31769089
130IMP metabolic process (GO:0046040)3.31701922
131bile acid and bile salt transport (GO:0015721)3.30511690
132regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30321660
133homocysteine metabolic process (GO:0050667)3.28818707
134energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28435164
135ATP synthesis coupled proton transport (GO:0015986)3.28435164
136reverse cholesterol transport (GO:0043691)3.28333052
137establishment of chromosome localization (GO:0051303)3.28227791
138DNA double-strand break processing (GO:0000729)3.28187178
139nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28171639
140protein deneddylation (GO:0000338)3.27799647
141rRNA methylation (GO:0031167)3.27125203
142drug catabolic process (GO:0042737)3.27034997
143regulation of cellular amino acid metabolic process (GO:0006521)3.26328054
144positive regulation of ligase activity (GO:0051351)3.25889034
145plasma lipoprotein particle clearance (GO:0034381)3.25785798
146phospholipid efflux (GO:0033700)3.25711685
147arginine metabolic process (GO:0006525)3.25587655
148serine family amino acid catabolic process (GO:0009071)3.25161512
149regulation of mitotic spindle checkpoint (GO:1903504)3.24624641
150regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.24624641
151NAD biosynthetic process (GO:0009435)3.23729703
152signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.22935200
153signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.22935200
154signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.22935200
155establishment of protein localization to mitochondrion (GO:0072655)3.22155508
156mitotic spindle assembly checkpoint (GO:0007094)3.22130476
157fibrinolysis (GO:0042730)3.21572932
158signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.21168242
159intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.21168242
160DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.21076869
161telomere maintenance via telomere lengthening (GO:0010833)3.20916537
162mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.20568679
163protein localization to mitochondrion (GO:0070585)3.20535688
164formation of translation preinitiation complex (GO:0001731)3.19844072
165heme metabolic process (GO:0042168)3.19181255
166DNA catabolic process, exonucleolytic (GO:0000738)3.19099044
167spindle assembly checkpoint (GO:0071173)3.18969654
168regulation of ubiquitin-protein transferase activity (GO:0051438)3.18152516
169signal transduction involved in DNA integrity checkpoint (GO:0072401)3.17538978
170signal transduction involved in DNA damage checkpoint (GO:0072422)3.17538978
171cholesterol biosynthetic process (GO:0006695)3.17118078
172blood coagulation, intrinsic pathway (GO:0007597)3.17062636
173transcription from mitochondrial promoter (GO:0006390)3.16899758
174electron transport chain (GO:0022900)3.14962824
175regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14920168
176response to methylmercury (GO:0051597)3.14179685
177amino-acid betaine metabolic process (GO:0006577)3.14152211
178triglyceride homeostasis (GO:0070328)3.12760326
179acylglycerol homeostasis (GO:0055090)3.12760326
180ethanol oxidation (GO:0006069)3.12685295
181carboxylic acid catabolic process (GO:0046395)3.11095871
182organic acid catabolic process (GO:0016054)3.11095871
183very-low-density lipoprotein particle assembly (GO:0034379)3.11007217
184drug transmembrane transport (GO:0006855)3.10716972
185low-density lipoprotein particle remodeling (GO:0034374)3.09313803
186nicotinamide nucleotide biosynthetic process (GO:0019359)3.06871937
187pyridine nucleotide biosynthetic process (GO:0019363)3.06871937
188very long-chain fatty acid metabolic process (GO:0000038)3.06456498
189thioester metabolic process (GO:0035383)3.05875190
190acyl-CoA metabolic process (GO:0006637)3.05875190
191peroxisome fission (GO:0016559)3.02813447
192dicarboxylic acid catabolic process (GO:0043649)3.01893117
193imidazole-containing compound metabolic process (GO:0052803)3.00651215
194respiratory electron transport chain (GO:0022904)3.00041230
195porphyrin-containing compound metabolic process (GO:0006778)2.98630191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.89071419
2E2F7_22180533_ChIP-Seq_HELA_Human7.01130920
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.28358593
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.27131264
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.14869701
6PPARA_22158963_ChIP-Seq_LIVER_Mouse4.29974255
7E2F4_17652178_ChIP-ChIP_JURKAT_Human4.12925243
8GABP_17652178_ChIP-ChIP_JURKAT_Human4.06479087
9MYC_18555785_ChIP-Seq_MESCs_Mouse4.06361483
10LXR_22158963_ChIP-Seq_LIVER_Mouse4.04936233
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.96724251
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.80524877
13* EST1_17652178_ChIP-ChIP_JURKAT_Human3.78826506
14FOXM1_23109430_ChIP-Seq_U2OS_Human3.49188936
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.39543360
16CREB1_15753290_ChIP-ChIP_HEK293T_Human3.30747931
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.27933156
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.10165293
19* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08181318
20ETS1_20019798_ChIP-Seq_JURKAT_Human3.07064919
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.02307523
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.99399798
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.90553900
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82804490
25TAF15_26573619_Chip-Seq_HEK293_Human2.82699034
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73166479
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.67746152
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.58450974
29ELK1_19687146_ChIP-ChIP_HELA_Human2.57111064
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54590445
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52967637
32DCP1A_22483619_ChIP-Seq_HELA_Human2.45544652
33* VDR_23849224_ChIP-Seq_CD4+_Human2.44525306
34FOXP3_21729870_ChIP-Seq_TREG_Human2.36160287
35AR_21909140_ChIP-Seq_LNCAP_Human2.34596574
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.34179178
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29830059
38GBX2_23144817_ChIP-Seq_PC3_Human2.29375211
39NELFA_20434984_ChIP-Seq_ESCs_Mouse2.25981189
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.15557752
41* XRN2_22483619_ChIP-Seq_HELA_Human2.15317058
42E2F1_21310950_ChIP-Seq_MCF-7_Human2.11107547
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.10601912
44TTF2_22483619_ChIP-Seq_HELA_Human2.05439991
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.05041068
46ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01879542
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97734375
48HTT_18923047_ChIP-ChIP_STHdh_Human1.96074848
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94085716
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.93844355
51* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.90907004
52GABP_19822575_ChIP-Seq_HepG2_Human1.88684123
53VDR_22108803_ChIP-Seq_LS180_Human1.87701111
54KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.86532994
55NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.81415822
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.77300272
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76285808
58* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73427901
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70746260
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70631813
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.62401623
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62281914
63TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56603180
64ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.56369600
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.55373265
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51777762
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.51324404
68GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45653586
69MYC_18940864_ChIP-ChIP_HL60_Human1.41991481
70P300_19829295_ChIP-Seq_ESCs_Human1.41593736
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.37724035
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.37724035
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.37146915
74KDM5A_27292631_Chip-Seq_BREAST_Human1.35408460
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.33669415
76* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.31426175
77* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28332127
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.26179075
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.26111514
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.25009033
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24546697
82SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23339045
83GATA1_22025678_ChIP-Seq_K562_Human1.23141734
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22558576
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22304410
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.21909242
87CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19628968
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.18239749
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15952151
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.15007419
91ER_23166858_ChIP-Seq_MCF-7_Human1.14935350
92EWS_26573619_Chip-Seq_HEK293_Human1.14637217
93ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14275575
94TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08363217
95IRF1_19129219_ChIP-ChIP_H3396_Human1.08056331
96* ELK1_22589737_ChIP-Seq_MCF10A_Human1.07643701
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.06911016
98* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06739080
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.05324375
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04808937
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04762335
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.03617496
103TFEB_21752829_ChIP-Seq_HELA_Human1.03497885
104RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01557229
105DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01474276
106SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01032595
107CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.00878511
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99844534
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99428673
110BMI1_23680149_ChIP-Seq_NPCS_Mouse0.98405954
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98267731
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.97590181
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.97258715
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96731236
115TAL1_26923725_Chip-Seq_HPCs_Mouse0.95915293
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95717696
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95098483
118SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95094895
119SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94646653
120IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.92604401
121CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92532299
122SRF_21415370_ChIP-Seq_HL-1_Mouse0.91539995
123NANOG_19829295_ChIP-Seq_ESCs_Human0.91437441
124SOX2_19829295_ChIP-Seq_ESCs_Human0.91437441
125SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91125843
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91063118
127* JUN_21703547_ChIP-Seq_K562_Human0.90754559
128AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90717640
129* FUS_26573619_Chip-Seq_HEK293_Human0.90461782
130NANOG_16153702_ChIP-ChIP_HESCs_Human0.90239236
131CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89851637
132KDM2B_26808549_Chip-Seq_REH_Human0.88412682
133PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87816042
134FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.87477895
135KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86612126
136SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86588811
137SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.85971092
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.85374127
139SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.84064508
140CIITA_25753668_ChIP-Seq_RAJI_Human0.83973689
141SMAD4_21799915_ChIP-Seq_A2780_Human0.83074683
142NR3C1_23031785_ChIP-Seq_PC12_Mouse0.83046258
143SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.81985203
144FOXA2_19822575_ChIP-Seq_HepG2_Human0.81912755
145CDX2_19796622_ChIP-Seq_MESCs_Mouse0.81892553
146Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.81345507
147EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.81045537
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.81014524
149EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.80971412
150PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80965428
151MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79930197
152EED_16625203_ChIP-ChIP_MESCs_Mouse0.79657086
153SALL4_22934838_ChIP-ChIP_CD34+_Human0.79643403
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.79566788
155NCOR_22424771_ChIP-Seq_293T_Human0.79330240
156SUZ12_18555785_Chip-Seq_ESCs_Mouse0.79108307
157SMAD3_21741376_ChIP-Seq_EPCs_Human0.78841176
158FLI1_27457419_Chip-Seq_LIVER_Mouse0.78186713
159EGR1_19032775_ChIP-ChIP_M12_Human0.78013274
160RUNX1_27457419_Chip-Seq_LIVER_Mouse0.77530475
161NANOG_18555785_Chip-Seq_ESCs_Mouse0.77160491
162P53_22387025_ChIP-Seq_ESCs_Mouse0.76878020
163ETV2_25802403_ChIP-Seq_MESCs_Mouse0.76505842
164CMYC_18555785_Chip-Seq_ESCs_Mouse0.76137604
165SMAD1_18555785_Chip-Seq_ESCs_Mouse0.75891227
166HNF4A_19822575_ChIP-Seq_HepG2_Human0.75275909
167SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.74941718
168FOXH1_21741376_ChIP-Seq_EPCs_Human0.74173240
169GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.74079333
170EZH2_27294783_Chip-Seq_NPCs_Mouse0.73837640
171* TP53_18474530_ChIP-ChIP_U2OS_Human0.72915516
172SOX2_16153702_ChIP-ChIP_HESCs_Human0.72667409
173KLF4_18555785_ChIP-Seq_MESCs_Mouse0.72536739
174CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.72315763
175SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.72148843
176AR_21572438_ChIP-Seq_LNCaP_Human0.71633336
177CRX_20693478_ChIP-Seq_RETINA_Mouse0.71603844
178KLF5_20875108_ChIP-Seq_MESCs_Mouse0.70768578
179PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70463173
180ELF5_23300383_ChIP-Seq_T47D_Human0.69533385
181HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.67562258
182NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.67273125
183TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.67162846
184CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.67041820
185POU5F1_16153702_ChIP-ChIP_HESCs_Human0.66200369
186STAT3_1855785_ChIP-Seq_MESCs_Mouse0.65939005
187TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64809093
188CHD1_26751641_Chip-Seq_LNCaP_Human0.64467506
189SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.63284968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.71043421
2MP0005360_urolithiasis6.15725025
3MP0010094_abnormal_chromosome_stability5.49720499
4MP0003693_abnormal_embryo_hatching5.34474109
5MP0005085_abnormal_gallbladder_physiolo5.13122386
6MP0005365_abnormal_bile_salt4.74569107
7MP0008058_abnormal_DNA_repair4.71295741
8MP0003111_abnormal_nucleus_morphology4.69202714
9MP0004957_abnormal_blastocyst_morpholog4.53999754
10MP0003806_abnormal_nucleotide_metabolis4.48883974
11MP0008875_abnormal_xenobiotic_pharmacok4.44547808
12MP0008057_abnormal_DNA_replication4.33028314
13MP0003077_abnormal_cell_cycle3.86346946
14MP0003656_abnormal_erythrocyte_physiolo3.19142954
15MP0005083_abnormal_biliary_tract3.14834055
16MP0003195_calcinosis3.11834529
17MP0008932_abnormal_embryonic_tissue3.11418853
18MP0008007_abnormal_cellular_replicative3.05433410
19MP0003252_abnormal_bile_duct2.62110381
20MP0005332_abnormal_amino_acid2.48081432
21MP0003786_premature_aging2.47764319
22MP0010329_abnormal_lipoprotein_level2.44914721
23MP0004147_increased_porphyrin_level2.44080246
24MP0001666_abnormal_nutrient_absorption2.30680587
25MP0003941_abnormal_skin_development2.00429514
26MP0003186_abnormal_redox_activity1.99780952
27MP0008877_abnormal_DNA_methylation1.87574541
28MP0000350_abnormal_cell_proliferation1.81750238
29MP0001730_embryonic_growth_arrest1.80503725
30MP0002138_abnormal_hepatobiliary_system1.75586887
31MP0002163_abnormal_gland_morphology1.73525762
32MP0009697_abnormal_copulation1.73470579
33MP0009840_abnormal_foam_cell1.73453936
34MP0002118_abnormal_lipid_homeostasis1.67188381
35MP0001764_abnormal_homeostasis1.66810381
36MP0006036_abnormal_mitochondrial_physio1.66403150
37MP0005584_abnormal_enzyme/coenzyme_acti1.65641531
38MP0004019_abnormal_vitamin_homeostasis1.61139570
39MP0001697_abnormal_embryo_size1.58597731
40MP0003880_abnormal_central_pattern1.56110530
41MP0005451_abnormal_body_composition1.55705755
42MP0005636_abnormal_mineral_homeostasis1.53930584
43MP0002938_white_spotting1.53793070
44MP0001529_abnormal_vocalization1.51427040
45MP0000358_abnormal_cell_content/1.49689805
46MP0002876_abnormal_thyroid_physiology1.48331148
47MP0001984_abnormal_olfaction1.47238548
48MP0003868_abnormal_feces_composition1.44332158
49MP0000609_abnormal_liver_physiology1.43642244
50MP0006072_abnormal_retinal_apoptosis1.41951638
51MP0000372_irregular_coat_pigmentation1.41554811
52MP0000313_abnormal_cell_death1.41293567
53MP0010307_abnormal_tumor_latency1.40294344
54MP0002837_dystrophic_cardiac_calcinosis1.38757733
55MP0003191_abnormal_cellular_cholesterol1.36028440
56MP0005319_abnormal_enzyme/_coenzyme1.35689829
57MP0006292_abnormal_olfactory_placode1.33990685
58MP0002080_prenatal_lethality1.30962354
59MP0006276_abnormal_autonomic_nervous1.29771172
60MP0001293_anophthalmia1.27081040
61MP0005380_embryogenesis_phenotype1.25607293
62MP0001672_abnormal_embryogenesis/_devel1.25607293
63MP0002736_abnormal_nociception_after1.25267760
64MP0001905_abnormal_dopamine_level1.25085466
65MP0004142_abnormal_muscle_tone1.24988044
66MP0010352_gastrointestinal_tract_polyps1.21033572
67MP0006035_abnormal_mitochondrial_morpho1.19523952
68MP0004043_abnormal_pH_regulation1.19022083
69MP0005084_abnormal_gallbladder_morpholo1.18727114
70MP0000604_amyloidosis1.16381796
71MP0009643_abnormal_urine_homeostasis1.15480496
72MP0002160_abnormal_reproductive_system1.14085998
73MP0005535_abnormal_body_temperature1.12744806
74MP0001968_abnormal_touch/_nociception1.12455775
75MP0002735_abnormal_chemical_nociception1.12195528
76MP0003329_amyloid_beta_deposits1.12065178
77MP0009764_decreased_sensitivity_to1.10663867
78MP0001188_hyperpigmentation1.10316813
79MP0002396_abnormal_hematopoietic_system1.09583306
80MP0002085_abnormal_embryonic_tissue1.09010054
81MP0002210_abnormal_sex_determination1.08640066
82MP0003984_embryonic_growth_retardation1.05230390
83MP0001929_abnormal_gametogenesis1.05182043
84MP0005408_hypopigmentation1.03321483
85MP0002019_abnormal_tumor_incidence1.01896923
86MP0002088_abnormal_embryonic_growth/wei1.01852080
87MP0008872_abnormal_physiological_respon1.01125740
88MP0008260_abnormal_autophagy1.00456409
89MP0002084_abnormal_developmental_patter0.99292121
90MP0004270_analgesia0.98244560
91MP0003890_abnormal_embryonic-extraembry0.96100846
92MP0005395_other_phenotype0.95537791
93MP0003123_paternal_imprinting0.93935627
94MP0004197_abnormal_fetal_growth/weight/0.92362049
95MP0005376_homeostasis/metabolism_phenot0.91303609
96MP0002822_catalepsy0.90741261
97MP0004215_abnormal_myocardial_fiber0.90380526
98MP0005647_abnormal_sex_gland0.88881477
99MP0001145_abnormal_male_reproductive0.87993801
100MP0002272_abnormal_nervous_system0.87457180
101MP0009745_abnormal_behavioral_response0.87143889
102MP0002095_abnormal_skin_pigmentation0.86777949
103MP0002064_seizures0.85629616
104MP0009672_abnormal_birth_weight0.85553503
105MP0003718_maternal_effect0.85287969
106MP0000920_abnormal_myelination0.85225065
107MP0003011_delayed_dark_adaptation0.84701183
108MP0005266_abnormal_metabolism0.84410713
109MP0009765_abnormal_xenobiotic_induced0.83850280
110MP0000653_abnormal_sex_gland0.82915211
111MP0001440_abnormal_grooming_behavior0.82684377
112MP0009763_increased_sensitivity_to0.81829669
113MP0009046_muscle_twitch0.80923782
114MP0003937_abnormal_limbs/digits/tail_de0.80838354
115MP0003567_abnormal_fetal_cardiomyocyte0.80734077
116MP0002102_abnormal_ear_morphology0.80535709
117MP0001727_abnormal_embryo_implantation0.79781659
118MP0003315_abnormal_perineum_morphology0.79212775
119MP0002877_abnormal_melanocyte_morpholog0.79082304
120MP0002734_abnormal_mechanical_nocicepti0.78418127
121MP0008469_abnormal_protein_level0.77744447
122MP0002086_abnormal_extraembryonic_tissu0.76914073
123MP0003950_abnormal_plasma_membrane0.76069244
124MP0003136_yellow_coat_color0.74936250
125MP0002638_abnormal_pupillary_reflex0.74141355
126MP0002234_abnormal_pharynx_morphology0.73991247
127MP0003690_abnormal_glial_cell0.73927384
128MP0003724_increased_susceptibility_to0.73057593
129MP0002332_abnormal_exercise_endurance0.73000947
130MP0001501_abnormal_sleep_pattern0.71743609
131MP0003646_muscle_fatigue0.71317537
132MP0000490_abnormal_crypts_of0.71156889
133MP0005075_abnormal_melanosome_morpholog0.70256459
134MP0005253_abnormal_eye_physiology0.69916011
135MP0005389_reproductive_system_phenotype0.69182633
136MP0009642_abnormal_blood_homeostasis0.68734597
137MP0001881_abnormal_mammary_gland0.68571092
138MP0005384_cellular_phenotype0.67888778
139MP0005386_behavior/neurological_phenoty0.67497752
140MP0004924_abnormal_behavior0.67497752
141MP0000647_abnormal_sebaceous_gland0.66707245
142MP0005174_abnormal_tail_pigmentation0.66213450
143MP0005448_abnormal_energy_balance0.65162506
144MP0001119_abnormal_female_reproductive0.64686297
145MP0002078_abnormal_glucose_homeostasis0.64433983
146MP0005501_abnormal_skin_physiology0.63379935
147MP0008874_decreased_physiological_sensi0.62018040
148MP0006082_CNS_inflammation0.61351874
149MP0003638_abnormal_response/metabolism_0.60618077
150MP0009379_abnormal_foot_pigmentation0.60608698
151MP0002697_abnormal_eye_size0.60495705
152MP0008789_abnormal_olfactory_epithelium0.60398106
153MP0002733_abnormal_thermal_nociception0.60174814
154MP0001286_abnormal_eye_development0.59484687
155MP0001853_heart_inflammation0.58915052
156MP0008873_increased_physiological_sensi0.58399565
157MP0000598_abnormal_liver_morphology0.57983912
158MP0001765_abnormal_ion_homeostasis0.57574267
159MP0002090_abnormal_vision0.57014021
160MP0001661_extended_life_span0.56376615
161MP0003075_altered_response_to0.56051829
162MP0002572_abnormal_emotion/affect_behav0.55633888
163MP0005330_cardiomyopathy0.55494350
164MP0002067_abnormal_sensory_capabilities0.54872237
165MP0005379_endocrine/exocrine_gland_phen0.54848456
166MP0002063_abnormal_learning/memory/cond0.54675733
167MP0003635_abnormal_synaptic_transmissio0.54562122
168MP0005645_abnormal_hypothalamus_physiol0.54323399
169MP0002229_neurodegeneration0.53210353
170MP0001542_abnormal_bone_strength0.52941851
171MP0003698_abnormal_male_reproductive0.52930991
172MP0001970_abnormal_pain_threshold0.52662423
173MP0009785_altered_susceptibility_to0.52440323
174MP0002111_abnormal_tail_morphology0.52229717
175MP0000230_abnormal_systemic_arterial0.52204697
176MP0002233_abnormal_nose_morphology0.52108218
177MP0005334_abnormal_fat_pad0.51694350
178MP0003121_genomic_imprinting0.51688810
179MP0001486_abnormal_startle_reflex0.51523980
180MP0005391_vision/eye_phenotype0.50763441
181MP0005220_abnormal_exocrine_pancreas0.50550030
182MP0002006_tumorigenesis0.49999045
183MP0002254_reproductive_system_inflammat0.49783388
184MP0009703_decreased_birth_body0.49701360

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.88830170
2Intrahepatic cholestasis (HP:0001406)5.17349167
3Prolonged partial thromboplastin time (HP:0003645)4.92134896
4Hypobetalipoproteinemia (HP:0003563)4.85258653
5Deep venous thrombosis (HP:0002625)4.66580035
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.31225407
7Xanthomatosis (HP:0000991)4.15754637
8Cerebral edema (HP:0002181)4.05665555
9Acute encephalopathy (HP:0006846)4.04228522
10Acute necrotizing encephalopathy (HP:0006965)3.85238053
11Hyperlipoproteinemia (HP:0010980)3.66647490
12Abnormal mitochondria in muscle tissue (HP:0008316)3.61985964
13Increased serum pyruvate (HP:0003542)3.50569871
14Abnormality of glycolysis (HP:0004366)3.50569871
15Fat malabsorption (HP:0002630)3.50491545
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.48976727
17Conjugated hyperbilirubinemia (HP:0002908)3.45751189
18Hyperbilirubinemia (HP:0002904)3.43123487
19Chromsome breakage (HP:0040012)3.35991950
20Hyperammonemia (HP:0001987)3.33450053
21Progressive macrocephaly (HP:0004481)3.30833170
22Abnormality of the heme biosynthetic pathway (HP:0010472)3.30600912
23Acanthocytosis (HP:0001927)3.30252127
24Abnormality of chromosome stability (HP:0003220)3.28799189
25Abnormality of the preputium (HP:0100587)3.26883544
26Birth length less than 3rd percentile (HP:0003561)3.23262192
27Cholecystitis (HP:0001082)3.19884027
28Abnormal gallbladder physiology (HP:0012438)3.19884027
29Abnormal gallbladder morphology (HP:0012437)3.19045624
30Hypochromic microcytic anemia (HP:0004840)3.18602008
31Abnormality of aspartate family amino acid metabolism (HP:0010899)3.18249294
32Hypolipoproteinemia (HP:0010981)3.17902067
33Ketosis (HP:0001946)3.17839294
34Joint hemorrhage (HP:0005261)3.16801909
35Hyperglycinemia (HP:0002154)3.15192359
36Cholelithiasis (HP:0001081)3.14141022
37Poikilocytosis (HP:0004447)3.12788066
38Mitochondrial inheritance (HP:0001427)3.11743927
39Increased serum lactate (HP:0002151)3.11172652
40Abnormality of methionine metabolism (HP:0010901)3.05129196
41Complement deficiency (HP:0004431)3.03811023
42Steatorrhea (HP:0002570)3.02719207
43Lethargy (HP:0001254)3.01113426
44Abnormality of glutamine family amino acid metabolism (HP:0010902)3.00019409
45Abnormality of the common coagulation pathway (HP:0010990)2.97761303
46Meckel diverticulum (HP:0002245)2.97424481
47Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.93411191
48Megaloblastic anemia (HP:0001889)2.89412286
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.89360257
50Epidermoid cyst (HP:0200040)2.86111907
51Hepatic necrosis (HP:0002605)2.84634733
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.80499101
53Abnormality of the ileum (HP:0001549)2.78341953
54Metabolic acidosis (HP:0001942)2.77573254
55Hepatocellular necrosis (HP:0001404)2.76085706
56Abnormality of serine family amino acid metabolism (HP:0010894)2.75785866
57Abnormality of glycine metabolism (HP:0010895)2.75785866
58Increased CSF lactate (HP:0002490)2.75752612
59Abnormality of fatty-acid metabolism (HP:0004359)2.72656214
60Macrocytic anemia (HP:0001972)2.72643329
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.69178568
62Microvesicular hepatic steatosis (HP:0001414)2.68260152
63Hypoglycemic coma (HP:0001325)2.61719434
64Exercise intolerance (HP:0003546)2.61178291
65Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.60929535
66Spontaneous abortion (HP:0005268)2.60227804
67Abnormality of the anterior horn cell (HP:0006802)2.52930892
68Degeneration of anterior horn cells (HP:0002398)2.52930892
69Abnormality of the labia minora (HP:0012880)2.52917811
70Aplastic anemia (HP:0001915)2.52652083
71Vomiting (HP:0002013)2.50348466
72Hyperglycinuria (HP:0003108)2.49606553
73Dicarboxylic aciduria (HP:0003215)2.47878957
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47878957
75Abnormality of serum amino acid levels (HP:0003112)2.42374494
76Abnormality of alanine metabolism (HP:0010916)2.41869469
77Hyperalaninemia (HP:0003348)2.41869469
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.41869469
79Abnormality of the gallbladder (HP:0005264)2.41443287
80Type I transferrin isoform profile (HP:0003642)2.41059049
81Hyperventilation (HP:0002883)2.41029296
82Small intestinal stenosis (HP:0012848)2.40407111
83Duodenal stenosis (HP:0100867)2.40407111
84Cerebral hemorrhage (HP:0001342)2.39812419
85Ketoacidosis (HP:0001993)2.38528840
86Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.37924843
87Colon cancer (HP:0003003)2.36802143
88Abnormality of the intrinsic pathway (HP:0010989)2.36525355
89Lactic acidosis (HP:0003128)2.35551316
90Oral leukoplakia (HP:0002745)2.34625628
91Abnormality of cells of the erythroid lineage (HP:0012130)2.30488606
923-Methylglutaconic aciduria (HP:0003535)2.30064010
93Leukodystrophy (HP:0002415)2.29894011
94Multiple enchondromatosis (HP:0005701)2.28128073
95Abnormal lung lobation (HP:0002101)2.27662455
96Hypoalphalipoproteinemia (HP:0003233)2.26411245
97Abnormal number of erythroid precursors (HP:0012131)2.25970217
98Abnormality of homocysteine metabolism (HP:0010919)2.25845683
99Homocystinuria (HP:0002156)2.25845683
100Gout (HP:0001997)2.21294712
101Myelodysplasia (HP:0002863)2.19988115
102Reduced antithrombin III activity (HP:0001976)2.18523019
103Delayed CNS myelination (HP:0002188)2.17857292
104Abnormality of pyrimidine metabolism (HP:0004353)2.17650380
105Glycosuria (HP:0003076)2.17460549
106Abnormality of urine glucose concentration (HP:0011016)2.17460549
107Pancytopenia (HP:0001876)2.17044771
108Cerebral hypomyelination (HP:0006808)2.15916257
109Hepatocellular carcinoma (HP:0001402)2.15792789
110Hypercholesterolemia (HP:0003124)2.14541920
111Abnormality of complement system (HP:0005339)2.12262901
112Nephroblastoma (Wilms tumor) (HP:0002667)2.12128964
113Abnormality of the duodenum (HP:0002246)2.11752730
114Lipid accumulation in hepatocytes (HP:0006561)2.11372397
115Optic disc pallor (HP:0000543)2.11221995
116Respiratory difficulties (HP:0002880)2.10282549
117Abnormality of nucleobase metabolism (HP:0010932)2.09292315
118Paralysis (HP:0003470)2.09070939
119Methylmalonic acidemia (HP:0002912)2.09023263
120Exertional dyspnea (HP:0002875)2.07650282
121Renal Fanconi syndrome (HP:0001994)2.06855545
122Irritability (HP:0000737)2.06130249
123Abnormality of purine metabolism (HP:0004352)2.05113282
124Parakeratosis (HP:0001036)2.03749209
125Progressive external ophthalmoplegia (HP:0000590)2.02743176
126Abnormality of the pons (HP:0007361)2.02693121
127Sloping forehead (HP:0000340)2.01485914
128Increased intramyocellular lipid droplets (HP:0012240)2.01456031
129Spastic paraparesis (HP:0002313)2.01155859
130Vascular calcification (HP:0004934)2.01035448
131Sensory axonal neuropathy (HP:0003390)2.00740944
132Brushfield spots (HP:0001088)2.00014760
133Embryonal renal neoplasm (HP:0011794)1.98492112
134Neuroendocrine neoplasm (HP:0100634)1.98172253
135Neoplasm of the adrenal gland (HP:0100631)1.97203887
136Respiratory failure (HP:0002878)1.96717075
137Reticulocytopenia (HP:0001896)1.96421599
138Increased muscle lipid content (HP:0009058)1.96111112
139Malnutrition (HP:0004395)1.95786761
140CNS demyelination (HP:0007305)1.95450863
141Reticulocytosis (HP:0001923)1.94733821
142Amniotic constriction ring (HP:0009775)1.94204313
143Abnormality of placental membranes (HP:0011409)1.94204313
144Methylmalonic aciduria (HP:0012120)1.94064672
145Sparse eyelashes (HP:0000653)1.93886811
146Clubbing of toes (HP:0100760)1.93223029
147Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92770059
148Pheochromocytoma (HP:0002666)1.91850667
149Abnormal protein glycosylation (HP:0012346)1.89789091
150Abnormal glycosylation (HP:0012345)1.89789091
151Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.89789091
152Abnormal protein N-linked glycosylation (HP:0012347)1.89789091
153Decreased activity of mitochondrial respiratory chain (HP:0008972)1.89473588
154Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.89473588
155Horseshoe kidney (HP:0000085)1.88199954
156Hypophosphatemic rickets (HP:0004912)1.87681634
157Increased hepatocellular lipid droplets (HP:0006565)1.86970072
158Secondary amenorrhea (HP:0000869)1.86001723
159Rough bone trabeculation (HP:0100670)1.84012577
160Absent thumb (HP:0009777)1.83608845
161Postnatal microcephaly (HP:0005484)1.81793808
162Abnormal umbilical cord blood vessels (HP:0011403)1.81030739
163Single umbilical artery (HP:0001195)1.81030739
164Abnormality of the fetal cardiovascular system (HP:0010948)1.81030739
165Abnormality of renal resorption (HP:0011038)1.79430623
166Pallor (HP:0000980)1.79323200
167Abnormality of vitamin B metabolism (HP:0004340)1.79233339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.43057344
2CASK3.69614841
3BCKDK3.65887925
4VRK23.40023245
5NEK13.24065572
6MAP3K123.19475118
7CDC73.15587237
8SRPK13.10408779
9TTK3.03526824
10TSSK62.95562247
11EIF2AK32.85141210
12PBK2.71476316
13STK392.60694801
14OXSR12.54874646
15ERBB42.54222889
16PLK32.32149955
17PLK42.29338684
18ARAF2.27382134
19ZAK2.25608556
20WEE12.25003515
21NME22.21139801
22TRIM282.10527542
23RIPK42.07825015
24MAP2K42.04496657
25BMPR22.01331127
26WNK42.00866785
27MKNK21.96405843
28MAP2K71.95146714
29BCR1.94983414
30MST41.94766468
31BRSK21.75535183
32CCNB11.72955575
33MKNK11.71686399
34STK161.70600567
35PLK11.67755041
36MST1R1.61105330
37ABL21.60206276
38MAPKAPK51.59784644
39GRK51.57940955
40NUAK11.55397195
41MAP3K141.55284863
42TAF11.54748220
43EPHA41.54121264
44NME11.46479400
45EIF2AK11.39933200
46DAPK21.38377986
47MAP3K41.35048705
48FRK1.32682028
49TAOK31.32175057
50PDK21.31526716
51CAMK2B1.31321900
52GRK71.31267157
53MET1.28085282
54ATR1.25373037
55AURKB1.24981145
56BRSK11.23550927
57CAMK2G1.19128625
58LIMK11.16846937
59MUSK1.14895962
60EIF2AK21.13711496
61PKN11.12469403
62PIK3CG1.12123886
63CHEK21.12009280
64CAMK2A1.09214080
65MYLK1.04469620
66CSNK1G21.03231684
67NTRK11.03118518
68CSNK1G31.02597853
69STK41.02214319
70PLK21.01281774
71SGK4940.99032767
72SGK2230.99032767
73PNCK0.98863077
74ADRBK20.92681909
75INSRR0.92414168
76SIK30.91635552
77TBK10.91196455
78CAMK2D0.90851639
79MOS0.87508639
80BRAF0.86029342
81FGFR40.85041249
82NTRK30.83532900
83SCYL20.83446531
84PINK10.83277641
85PAK40.82377142
86MAP4K20.79798735
87ATM0.79742230
88PIK3CA0.79657093
89ALK0.78467935
90CHEK10.78379616
91GRK60.77923218
92MAP3K130.77906526
93MAP2K10.77865305
94PAK30.77116630
95CDK80.76228482
96CDK190.75012993
97PASK0.73972858
98AURKA0.73066501
99PRKCQ0.72569066
100MAPK120.70363592
101NEK20.69477381
102PRKCE0.68966201
103DAPK10.68936693
104STK38L0.67838891
105PRKCG0.67280057
106RPS6KA40.66921728
107CSNK1G10.64950304
108CDK70.64649940
109STK30.64599280
110FGR0.64413826
111MINK10.63704033
112KSR20.63193984
113CSNK2A20.62442220
114SIK10.62241807
115WNK30.61938062
116ERBB30.61666107
117PTK2B0.60429219
118TLK10.60423196
119CDK30.60038583
120IKBKE0.59616419
121DYRK20.59575966
122PRKACA0.59088218
123STK240.59014548
124PHKG20.58817679
125PHKG10.58817679
126CSNK2A10.57907420
127MAPK130.55826385
128PDK40.55308591
129PDK30.55308591
130MAP3K110.53683979
131STK100.53468953
132PRKACG0.51081111
133RPS6KB20.50888998
134MAP3K80.50848198
135FGFR20.50485634
136EPHB10.49882033
137MAPK110.49608684
138IKBKB0.48211066
139VRK10.47908670
140TNIK0.47757404
141ADRBK10.47576356
142MAPK40.46177412
143TYK20.45510068
144MAP3K60.45392863
145CSNK1A1L0.44859485
146BMPR1B0.44544285
147CDK10.44517778
148CDK140.42835134
149JAK20.42735030
150PRKCZ0.42287319
151RPS6KA50.41840451
152CSNK1E0.41544687
153ACVR1B0.41502183
154PRKAA20.40897571
155CLK10.40699544
156CDK180.40500861
157PRKCA0.39614398
158OBSCN0.39295900
159PRKCI0.39051329
160CDK20.37527843
161PRKDC0.36525097
162MELK0.35326629
163DYRK30.33302019
164ILK0.31503674
165AKT20.27317835
166CDK40.25851913
167KDR0.25540683
168YES10.23408092
169GRK10.21980622
170FGFR10.21587293
171PIM10.20365918
172PAK10.19677281
173PIM20.19187794
174MAP3K100.16920589
175SMG10.14392868

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.06636146
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.67583989
3Mismatch repair_Homo sapiens_hsa034303.62884477
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32698183
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.10387664
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04969511
7Ribosome_Homo sapiens_hsa030103.02775945
8RNA polymerase_Homo sapiens_hsa030202.80832008
9Homologous recombination_Homo sapiens_hsa034402.80534436
10Non-homologous end-joining_Homo sapiens_hsa034502.77199880
11Nucleotide excision repair_Homo sapiens_hsa034202.60863303
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.60574433
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.53911924
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.47196738
15Butanoate metabolism_Homo sapiens_hsa006502.46109777
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38421214
17Spliceosome_Homo sapiens_hsa030402.33623703
18One carbon pool by folate_Homo sapiens_hsa006702.31889944
19Arginine biosynthesis_Homo sapiens_hsa002202.31349666
20Tryptophan metabolism_Homo sapiens_hsa003802.29015696
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28106340
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25500908
23Base excision repair_Homo sapiens_hsa034102.21703615
24Sulfur metabolism_Homo sapiens_hsa009202.20904515
25Nitrogen metabolism_Homo sapiens_hsa009102.19097678
26Oxidative phosphorylation_Homo sapiens_hsa001902.17991528
27RNA transport_Homo sapiens_hsa030132.11874444
28Pyrimidine metabolism_Homo sapiens_hsa002402.10028686
29Peroxisome_Homo sapiens_hsa041462.10017103
30Propanoate metabolism_Homo sapiens_hsa006402.07741095
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.07374244
32Fatty acid elongation_Homo sapiens_hsa000621.99102743
33Basal transcription factors_Homo sapiens_hsa030221.95978081
34Complement and coagulation cascades_Homo sapiens_hsa046101.95464176
35Fanconi anemia pathway_Homo sapiens_hsa034601.94829528
36Steroid biosynthesis_Homo sapiens_hsa001001.91536138
37Cell cycle_Homo sapiens_hsa041101.91232469
38Fatty acid degradation_Homo sapiens_hsa000711.90365048
39Histidine metabolism_Homo sapiens_hsa003401.89968974
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88030037
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.87955942
42Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82227608
43Chemical carcinogenesis_Homo sapiens_hsa052041.77229786
44Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.76437809
45RNA degradation_Homo sapiens_hsa030181.74223319
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.72842828
47Pyruvate metabolism_Homo sapiens_hsa006201.72702578
48Parkinsons disease_Homo sapiens_hsa050121.67884988
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.66073382
50Phenylalanine metabolism_Homo sapiens_hsa003601.56561280
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52862714
52Fatty acid metabolism_Homo sapiens_hsa012121.47144638
53Purine metabolism_Homo sapiens_hsa002301.46294303
54beta-Alanine metabolism_Homo sapiens_hsa004101.46083038
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.43673561
56Tyrosine metabolism_Homo sapiens_hsa003501.41613557
57Retinol metabolism_Homo sapiens_hsa008301.37167181
58Vitamin B6 metabolism_Homo sapiens_hsa007501.33537897
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27395029
60Alzheimers disease_Homo sapiens_hsa050101.27069273
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.24026740
62PPAR signaling pathway_Homo sapiens_hsa033201.22940289
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.22105616
64Caffeine metabolism_Homo sapiens_hsa002321.19846259
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16743780
66Cysteine and methionine metabolism_Homo sapiens_hsa002701.15843235
67Folate biosynthesis_Homo sapiens_hsa007901.15812933
68Collecting duct acid secretion_Homo sapiens_hsa049661.14951215
69Bile secretion_Homo sapiens_hsa049761.11404558
70Staphylococcus aureus infection_Homo sapiens_hsa051501.11170345
71Carbon metabolism_Homo sapiens_hsa012001.01439084
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98464028
73Arginine and proline metabolism_Homo sapiens_hsa003300.92997804
74mRNA surveillance pathway_Homo sapiens_hsa030150.90391436
75Starch and sucrose metabolism_Homo sapiens_hsa005000.89833865
76Huntingtons disease_Homo sapiens_hsa050160.87447579
77Sulfur relay system_Homo sapiens_hsa041220.83952947
78ABC transporters_Homo sapiens_hsa020100.83916874
79Oocyte meiosis_Homo sapiens_hsa041140.83425493
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83403782
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.81454655
82Glutathione metabolism_Homo sapiens_hsa004800.80588332
83Fat digestion and absorption_Homo sapiens_hsa049750.80584760
84Biosynthesis of amino acids_Homo sapiens_hsa012300.76738656
85p53 signaling pathway_Homo sapiens_hsa041150.76535731
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75738656
87Selenocompound metabolism_Homo sapiens_hsa004500.75707606
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75555579
89Metabolic pathways_Homo sapiens_hsa011000.70363742
90Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.69495047
91Vitamin digestion and absorption_Homo sapiens_hsa049770.67849978
92N-Glycan biosynthesis_Homo sapiens_hsa005100.64344719
93Proteasome_Homo sapiens_hsa030500.64250715
94Linoleic acid metabolism_Homo sapiens_hsa005910.58391552
95Protein export_Homo sapiens_hsa030600.57952679
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56823587
97Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56457937
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.56336017
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.49157342
100Systemic lupus erythematosus_Homo sapiens_hsa053220.45898492
101Epstein-Barr virus infection_Homo sapiens_hsa051690.44273981
102Ether lipid metabolism_Homo sapiens_hsa005650.43162419
103Regulation of autophagy_Homo sapiens_hsa041400.42325163
104Glycerolipid metabolism_Homo sapiens_hsa005610.39895828
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37917150
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36165976
107Pentose phosphate pathway_Homo sapiens_hsa000300.34254020
108Cardiac muscle contraction_Homo sapiens_hsa042600.33186529
109Vibrio cholerae infection_Homo sapiens_hsa051100.32335094
110Rheumatoid arthritis_Homo sapiens_hsa053230.30949203
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.28826474
112Alcoholism_Homo sapiens_hsa050340.27188601
113Synaptic vesicle cycle_Homo sapiens_hsa047210.26745073
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25028246
115Phagosome_Homo sapiens_hsa041450.22630238
116GABAergic synapse_Homo sapiens_hsa047270.22470688
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20602195
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19713755
119Viral carcinogenesis_Homo sapiens_hsa052030.18777040
120Prion diseases_Homo sapiens_hsa050200.15239445
121Nicotine addiction_Homo sapiens_hsa050330.15189201
122African trypanosomiasis_Homo sapiens_hsa051430.14879244
123Arachidonic acid metabolism_Homo sapiens_hsa005900.13496054
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.12608653
125TGF-beta signaling pathway_Homo sapiens_hsa043500.11360982
126Phototransduction_Homo sapiens_hsa047440.10007807
127Fatty acid biosynthesis_Homo sapiens_hsa000610.09092445
128Serotonergic synapse_Homo sapiens_hsa047260.08664574
129Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.07510417
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.07128088
131Asthma_Homo sapiens_hsa053100.03660032
132Ovarian steroidogenesis_Homo sapiens_hsa049130.03057903
133Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.02914712
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.02385286
135Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.01313331
136HTLV-I infection_Homo sapiens_hsa051660.00922247
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.0380231
138Galactose metabolism_Homo sapiens_hsa00052-0.0219791
139Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0139636
140Herpes simplex infection_Homo sapiens_hsa05168-0.0091770
141Mineral absorption_Homo sapiens_hsa04978-0.0044108

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