CHAC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the gamma-glutamylcyclotransferase family of proteins. The encoded protein has been shown to promote neuronal differentiation by deglycination of the Notch receptor, which prevents receptor maturation and inhibits Notch signaling. This protein may also play a role in the unfolded protein response, and in regulation of glutathione levels and oxidative balance in the cell. Elevated expression of this gene may indicate increased risk of cancer recurrence among breast and ovarian cancer patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)6.62512897
2maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.48429890
3protein retention in ER lumen (GO:0006621)6.08640575
4folic acid-containing compound biosynthetic process (GO:0009396)5.59949564
5Golgi transport vesicle coating (GO:0048200)5.59253800
6COPI coating of Golgi vesicle (GO:0048205)5.59253800
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.18012905
8cell migration involved in gastrulation (GO:0042074)5.10840899
9positive regulation of nuclease activity (GO:0032075)5.02475990
10somite rostral/caudal axis specification (GO:0032525)4.84076027
11hair cycle (GO:0042633)4.83615363
12molting cycle (GO:0042303)4.83615363
13* intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)4.83492946
14muscle organ morphogenesis (GO:0048644)4.67684003
15proline biosynthetic process (GO:0006561)4.67409849
16endoplasmic reticulum unfolded protein response (GO:0030968)4.62602551
17regulation of nuclease activity (GO:0032069)4.60645298
18cellular response to unfolded protein (GO:0034620)4.54576745
19intestinal cholesterol absorption (GO:0030299)4.53542650
20signal transduction involved in regulation of gene expression (GO:0023019)4.48666383
21L-alpha-amino acid transmembrane transport (GO:1902475)4.43957444
22protein maturation by protein folding (GO:0022417)4.42518746
23pteridine-containing compound biosynthetic process (GO:0042559)4.37451481
24peptidyl-proline hydroxylation (GO:0019511)4.37127669
25cellular response to topologically incorrect protein (GO:0035967)4.28262806
26ER-nucleus signaling pathway (GO:0006984)4.27066939
27regulation of translational fidelity (GO:0006450)4.22901179
28digestion (GO:0007586)4.19779945
29tetrahydrofolate metabolic process (GO:0046653)4.19050332
30notochord development (GO:0030903)4.16356345
31maintenance of protein localization in organelle (GO:0072595)4.12932884
32tRNA aminoacylation for protein translation (GO:0006418)4.09703953
33* response to endoplasmic reticulum stress (GO:0034976)4.05451128
34negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.04182639
35L-serine metabolic process (GO:0006563)4.02830638
36intestinal epithelial cell development (GO:0060576)3.94338742
37tRNA aminoacylation (GO:0043039)3.91696188
38amino acid activation (GO:0043038)3.91696188
39ER overload response (GO:0006983)3.91325626
40coenzyme catabolic process (GO:0009109)3.89012379
41cellular modified amino acid catabolic process (GO:0042219)3.80399071
42negative regulation of epidermis development (GO:0045683)3.77941442
43COPII vesicle coating (GO:0048208)3.77015315
44polyketide metabolic process (GO:0030638)3.73398678
45doxorubicin metabolic process (GO:0044598)3.73398678
46daunorubicin metabolic process (GO:0044597)3.73398678
47protein hydroxylation (GO:0018126)3.72346172
48primitive streak formation (GO:0090009)3.69932183
49GDP-mannose metabolic process (GO:0019673)3.65796792
50formation of translation preinitiation complex (GO:0001731)3.63083544
51nucleotide-sugar biosynthetic process (GO:0009226)3.57796461
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.50916362
53regulation of translation in response to stress (GO:0043555)3.49621095
54protein complex localization (GO:0031503)3.48032230
55* response to unfolded protein (GO:0006986)3.47307545
56serine family amino acid biosynthetic process (GO:0009070)3.46294914
57retinoic acid receptor signaling pathway (GO:0048384)3.44720887
58establishment of integrated proviral latency (GO:0075713)3.37359088
59cellular protein complex localization (GO:0034629)3.35504690
604-hydroxyproline metabolic process (GO:0019471)3.34845003
61planar cell polarity pathway involved in neural tube closure (GO:0090179)3.30093067
62* response to topologically incorrect protein (GO:0035966)3.28604377
63regulation of response to osmotic stress (GO:0047484)3.25514285
64polarized epithelial cell differentiation (GO:0030859)3.24851093
65one-carbon metabolic process (GO:0006730)3.22238517
66cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.22223877
67protein heterotrimerization (GO:0070208)3.20660668
68IMP biosynthetic process (GO:0006188)3.20469838
69heterochromatin organization (GO:0070828)3.18864959
70negative regulation of epidermal cell differentiation (GO:0045605)3.16216301
71bone trabecula formation (GO:0060346)3.15109119
72mitochondrial DNA metabolic process (GO:0032042)3.14847355
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.11575160
74secondary heart field specification (GO:0003139)3.11137784
75heart field specification (GO:0003128)3.11137784
76cellular response to glucose starvation (GO:0042149)3.10810290
77protein localization to kinetochore (GO:0034501)3.10149910
78keratan sulfate catabolic process (GO:0042340)3.09175042
79ribosome biogenesis (GO:0042254)3.08246170
80folic acid-containing compound metabolic process (GO:0006760)3.08115348
81regulation of apoptotic process involved in morphogenesis (GO:1902337)3.05446284
82negative regulation of cell fate commitment (GO:0010454)3.02908693
83regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.02494587
84regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.00542351
85cullin deneddylation (GO:0010388)3.00211461
86maternal placenta development (GO:0001893)2.99900339
87histone H4-K12 acetylation (GO:0043983)2.99264450
88DNA replication checkpoint (GO:0000076)2.98996445
89regulation of tight junction assembly (GO:2000810)2.98982952
90regulation of translational elongation (GO:0006448)2.96299643
91anterior/posterior axis specification, embryo (GO:0008595)2.94957150
92regulation of mesoderm development (GO:2000380)2.93790176
93negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.92632382
94regulation of gene silencing by RNA (GO:0060966)2.90888701
95regulation of posttranscriptional gene silencing (GO:0060147)2.90888701
96regulation of gene silencing by miRNA (GO:0060964)2.90888701
97establishment of viral latency (GO:0019043)2.88590093
98cytidine metabolic process (GO:0046087)2.86679018
99cytidine catabolic process (GO:0006216)2.86679018
100cytidine deamination (GO:0009972)2.86679018
101pteridine-containing compound metabolic process (GO:0042558)2.86256282
102UDP-N-acetylglucosamine metabolic process (GO:0006047)2.85581783
103rRNA transcription (GO:0009303)2.85183136
104nuclear envelope reassembly (GO:0031468)2.84499297
105mitotic nuclear envelope reassembly (GO:0007084)2.84499297
106histone arginine methylation (GO:0034969)2.83851219
107paraxial mesoderm development (GO:0048339)2.81286087
108L-serine transport (GO:0015825)2.80635961
109negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.79260827
110regulation of oxidative stress-induced neuron death (GO:1903203)2.79060966
111regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.76928176
112convergent extension (GO:0060026)2.76081649
113regulation of mammary gland epithelial cell proliferation (GO:0033599)2.75930187
114skin morphogenesis (GO:0043589)2.74992169
115oxaloacetate metabolic process (GO:0006107)2.73998552
116regulation of translational termination (GO:0006449)2.71701575
117pyrimidine ribonucleoside catabolic process (GO:0046133)2.71490660
118kinetochore assembly (GO:0051382)2.70551569
119serine transport (GO:0032329)2.65779231
120DNA strand elongation involved in DNA replication (GO:0006271)2.64372871
121ribosome assembly (GO:0042255)2.59120633
122mitotic metaphase plate congression (GO:0007080)2.57906751
123DNA strand elongation (GO:0022616)2.55971182
124establishment of apical/basal cell polarity (GO:0035089)2.55854747
125DNA unwinding involved in DNA replication (GO:0006268)2.54455856
126serine family amino acid metabolic process (GO:0009069)2.51554772
127peptidyl-arginine omega-N-methylation (GO:0035247)2.50097811
128ribonucleoprotein complex biogenesis (GO:0022613)2.49418774
129chaperone-mediated protein transport (GO:0072321)2.49392811
130regulation of cell fate specification (GO:0042659)2.49070688
131tooth mineralization (GO:0034505)2.46732192
132proteasome assembly (GO:0043248)2.42601155
133regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.42485127
134ribosomal small subunit biogenesis (GO:0042274)2.39336349
135protein localization to chromosome, centromeric region (GO:0071459)2.37464428
136tRNA metabolic process (GO:0006399)2.36817401
137DNA damage response, detection of DNA damage (GO:0042769)2.36347122
138chromatin assembly (GO:0031497)2.36316162
139ribosomal large subunit biogenesis (GO:0042273)2.35818664
140termination of RNA polymerase I transcription (GO:0006363)2.33991039
141establishment of monopolar cell polarity (GO:0061162)2.31732992
142establishment or maintenance of monopolar cell polarity (GO:0061339)2.31732992
143glycine metabolic process (GO:0006544)2.29643907
144regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.29571669
145negative regulation of androgen receptor signaling pathway (GO:0060766)2.29537357
146maturation of SSU-rRNA (GO:0030490)2.28476689
147glutamine metabolic process (GO:0006541)2.26054837
148DNA replication initiation (GO:0006270)2.25724544
149nucleobase-containing small molecule interconversion (GO:0015949)2.25696251
150cerebellar Purkinje cell layer development (GO:0021680)2.25230184
151neutral amino acid transport (GO:0015804)2.25015025
152kinetochore organization (GO:0051383)2.25000157
153hippo signaling (GO:0035329)2.24927358
154ventricular cardiac muscle cell development (GO:0055015)2.23765752
155response to redox state (GO:0051775)2.23176009
156termination of RNA polymerase III transcription (GO:0006386)2.23049632
157transcription elongation from RNA polymerase III promoter (GO:0006385)2.23049632
158chromatin remodeling at centromere (GO:0031055)2.21911223
159mitotic chromosome condensation (GO:0007076)2.20809763
160nodal signaling pathway (GO:0038092)2.20073792
161transcription from RNA polymerase I promoter (GO:0006360)2.19430540

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.46063652
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.46063652
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.46063652
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.10521943
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.49073938
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23279244
7TP63_17297297_ChIP-ChIP_HaCaT_Human3.18692477
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.98162009
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52147555
10POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.51897706
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46337332
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.43352443
13ZNF263_19887448_ChIP-Seq_K562_Human2.22050584
14NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17427678
15ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.17185174
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.10068423
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.07940071
18STAT3_1855785_ChIP-Seq_MESCs_Mouse2.05383736
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04721176
20SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.03665610
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.02422221
22* ATF3_27146783_Chip-Seq_COLON_Human1.99839833
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98687881
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83855366
25E2F7_22180533_ChIP-Seq_HELA_Human1.80196187
26EGR1_19374776_ChIP-ChIP_THP-1_Human1.79901701
27ETS1_20019798_ChIP-Seq_JURKAT_Human1.79310063
28TCF3_18692474_ChIP-Seq_MEFs_Mouse1.77122603
29KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.76091472
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74035728
31SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.72692817
32RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68554125
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.64085904
34BP1_19119308_ChIP-ChIP_Hs578T_Human1.60517902
35FOXM1_23109430_ChIP-Seq_U2OS_Human1.60390450
36* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.57920457
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.55401910
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.52145311
39TFEB_21752829_ChIP-Seq_HELA_Human1.50689384
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.49659675
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47875618
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47286818
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46584864
44POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44933674
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.44269585
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.43606369
47* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.42979714
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.41703224
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41103819
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40648722
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.40621248
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40488144
53TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39737980
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39364433
55TCF3_18692474_ChIP-Seq_MESCs_Mouse1.37789971
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37545023
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.37179465
58CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35769280
59DCP1A_22483619_ChIP-Seq_HELA_Human1.35064354
60* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34805390
61ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34561434
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.33317221
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.31853844
64XRN2_22483619_ChIP-Seq_HELA_Human1.31546595
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.30920109
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30214752
67PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28385382
68* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26644227
69RACK7_27058665_Chip-Seq_MCF-7_Human1.26524107
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25700863
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24789309
72TP53_22127205_ChIP-Seq_IMR90_Human1.23659460
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.23075012
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22990965
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22816108
76BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.21257911
77NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.20497841
78FOXP3_21729870_ChIP-Seq_TREG_Human1.19978295
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19198728
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18275751
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17678325
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17372065
83SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.17008378
84ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16377905
85AR_21909140_ChIP-Seq_LNCAP_Human1.13864717
86UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13486848
87* MYC_22102868_ChIP-Seq_BL_Human1.12525860
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12208420
89OCT4_18692474_ChIP-Seq_MEFs_Mouse1.12028691
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10180611
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.09589051
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.09249167
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08869760
94THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08652498
95P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08260422
96TTF2_22483619_ChIP-Seq_HELA_Human1.08100450
97DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07861441
98* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07127979
99YY1_21170310_ChIP-Seq_MESCs_Mouse1.06176296
100* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.05282235
101KDM5A_27292631_Chip-Seq_BREAST_Human1.05128484
102ELK3_25401928_ChIP-Seq_HUVEC_Human1.05032465
103GABP_19822575_ChIP-Seq_HepG2_Human1.05024736
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04638048
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03403816
106GATA6_25053715_ChIP-Seq_YYC3_Human1.03390044
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03292545
108TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02490486
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00157580
110POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99793318
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99590866
112CHD1_26751641_Chip-Seq_LNCaP_Human0.99492895
113NANOG_16153702_ChIP-ChIP_HESCs_Human0.98672643
114* TET1_21451524_ChIP-Seq_MESCs_Mouse0.98424227
115TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98053853
116SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97706013
117FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95741102
118SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95080042
119TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94162552
120* FOXP1_21924763_ChIP-Seq_HESCs_Human0.93853514
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93209386
122CLOCK_20551151_ChIP-Seq_293T_Human0.92223027
123NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92189351
124WT1_19549856_ChIP-ChIP_CCG9911_Human0.92059536
125GATA3_24758297_ChIP-Seq_MCF-7_Human0.91984679
126LXR_22292898_ChIP-Seq_THP-1_Human0.91380549
127KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.90519564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.55697228
2MP0003941_abnormal_skin_development3.51669588
3MP0003283_abnormal_digestive_organ2.88656902
4MP0010352_gastrointestinal_tract_polyps2.74911402
5MP0005220_abnormal_exocrine_pancreas2.65378906
6MP0003890_abnormal_embryonic-extraembry2.60992408
7MP0004264_abnormal_extraembryonic_tissu2.54467947
8MP0005083_abnormal_biliary_tract2.52651165
9MP0000678_abnormal_parathyroid_gland2.49673172
10MP0008438_abnormal_cutaneous_collagen2.39276277
11MP0005501_abnormal_skin_physiology2.30653918
12MP0002877_abnormal_melanocyte_morpholog2.27282094
13MP0000750_abnormal_muscle_regeneration2.18963830
14MP0003111_abnormal_nucleus_morphology2.14304173
15MP0002234_abnormal_pharynx_morphology2.13754795
16MP0000749_muscle_degeneration2.13156799
17MP0001666_abnormal_nutrient_absorption2.03320282
18MP0010030_abnormal_orbit_morphology1.99417905
19MP0004957_abnormal_blastocyst_morpholog1.96220273
20MP0002332_abnormal_exercise_endurance1.95039438
21MP0001529_abnormal_vocalization1.92885883
22MP0003119_abnormal_digestive_system1.87235880
23MP0005257_abnormal_intraocular_pressure1.86391641
24MP0005275_abnormal_skin_tensile1.73037576
25MP0002269_muscular_atrophy1.72331557
26MP0004858_abnormal_nervous_system1.69077834
27MP0003566_abnormal_cell_adhesion1.64438163
28MP0008058_abnormal_DNA_repair1.64078045
29MP0002254_reproductive_system_inflammat1.62936100
30MP0001348_abnormal_lacrimal_gland1.61657659
31MP0000762_abnormal_tongue_morphology1.61409555
32MP0001542_abnormal_bone_strength1.61037204
33MP0004233_abnormal_muscle_weight1.58591336
34MP0009672_abnormal_birth_weight1.56199998
35MP0010094_abnormal_chromosome_stability1.55015462
36MP0002653_abnormal_ependyma_morphology1.51461331
37MP0003077_abnormal_cell_cycle1.50322597
38MP0004145_abnormal_muscle_electrophysio1.45885878
39MP0003123_paternal_imprinting1.45168360
40MP0008961_abnormal_basal_metabolism1.43244191
41MP0005023_abnormal_wound_healing1.42086187
42MP0004133_heterotaxia1.40605905
43MP0005394_taste/olfaction_phenotype1.40503581
44MP0005499_abnormal_olfactory_system1.40503581
45MP0000163_abnormal_cartilage_morphology1.40321126
46MP0002932_abnormal_joint_morphology1.39510727
47MP0003279_aneurysm1.38203181
48MP0005508_abnormal_skeleton_morphology1.35348355
49MP0002098_abnormal_vibrissa_morphology1.33985663
50MP0002111_abnormal_tail_morphology1.33417611
51MP0000759_abnormal_skeletal_muscle1.31509533
52MP0004197_abnormal_fetal_growth/weight/1.30148114
53MP0001188_hyperpigmentation1.27364970
54MP0003186_abnormal_redox_activity1.27179172
55MP0002693_abnormal_pancreas_physiology1.26007365
56MP0000049_abnormal_middle_ear1.23215086
57MP0003122_maternal_imprinting1.22602817
58MP0001672_abnormal_embryogenesis/_devel1.22454529
59MP0005380_embryogenesis_phenotype1.22454529
60MP0002896_abnormal_bone_mineralization1.21222312
61MP0003755_abnormal_palate_morphology1.20383848
62MP0009250_abnormal_appendicular_skeleto1.18207783
63MP0000579_abnormal_nail_morphology1.17073430
64MP0002909_abnormal_adrenal_gland1.16850687
65MP0003718_maternal_effect1.16487806
66MP0008932_abnormal_embryonic_tissue1.15856200
67MP0002080_prenatal_lethality1.15609322
68MP0002697_abnormal_eye_size1.13873541
69MP0002088_abnormal_embryonic_growth/wei1.13837284
70MP0003868_abnormal_feces_composition1.12751818
71MP0000358_abnormal_cell_content/1.12580163
72MP0003011_delayed_dark_adaptation1.12569166
73MP0003984_embryonic_growth_retardation1.12451280
74MP0000751_myopathy1.12250875
75MP0003385_abnormal_body_wall1.11869180
76MP0006035_abnormal_mitochondrial_morpho1.11615578
77MP0005076_abnormal_cell_differentiation1.10234627
78MP0002796_impaired_skin_barrier1.09630753
79MP0001243_abnormal_dermal_layer1.09303562
80MP0000467_abnormal_esophagus_morphology1.08509192
81MP0002084_abnormal_developmental_patter1.08503275
82MP0003806_abnormal_nucleotide_metabolis1.08080635
83MP0000432_abnormal_head_morphology1.07902957
84MP0000428_abnormal_craniofacial_morphol1.07530844
85MP0003942_abnormal_urinary_system1.07113606
86MP0010771_integument_phenotype1.06415994
87MP0009053_abnormal_anal_canal1.06407627
88MP0001944_abnormal_pancreas_morphology1.06385337
89MP0001849_ear_inflammation1.04613563
90MP0000350_abnormal_cell_proliferation1.03500704
91MP0005503_abnormal_tendon_morphology1.02670514
92MP0004185_abnormal_adipocyte_glucose1.01719971
93MP0010234_abnormal_vibrissa_follicle1.01336143
94MP0002114_abnormal_axial_skeleton1.00007556
95MP0009780_abnormal_chondrocyte_physiolo0.99814333
96MP0000013_abnormal_adipose_tissue0.99288979
97MP0000733_abnormal_muscle_development0.99177045
98MP0002089_abnormal_postnatal_growth/wei0.98842952
99MP0004043_abnormal_pH_regulation0.98770889
100MP0005623_abnormal_meninges_morphology0.97924392
101MP0003937_abnormal_limbs/digits/tail_de0.97530394
102MP0002177_abnormal_outer_ear0.97503331
103MP0003786_premature_aging0.96729379
104MP0001299_abnormal_eye_distance/0.94479798
105MP0003693_abnormal_embryo_hatching0.94449019
106MP0004087_abnormal_muscle_fiber0.94337536
107MP0000377_abnormal_hair_follicle0.94058756
108MP0003935_abnormal_craniofacial_develop0.94057227
109MP0002085_abnormal_embryonic_tissue0.93779633
110MP0002108_abnormal_muscle_morphology0.93547243
111MP0003861_abnormal_nervous_system0.92499767
112MP0009384_cardiac_valve_regurgitation0.91985927
113MP0000747_muscle_weakness0.91771543
114MP0008007_abnormal_cellular_replicative0.91657701
115MP0008789_abnormal_olfactory_epithelium0.91150911
116MP0002249_abnormal_larynx_morphology0.90410533
117MP0000537_abnormal_urethra_morphology0.90086776
118MP0000647_abnormal_sebaceous_gland0.89339797
119MP0002295_abnormal_pulmonary_circulatio0.89133062
120MP0000003_abnormal_adipose_tissue0.87966024
121MP0001730_embryonic_growth_arrest0.87836459
122MP0002116_abnormal_craniofacial_bone0.86260008
123MP0002060_abnormal_skin_morphology0.85922866
124MP0001286_abnormal_eye_development0.84658615
125MP0001697_abnormal_embryo_size0.84293842
126MP0002970_abnormal_white_adipose0.82347468
127MP0005670_abnormal_white_adipose0.81882067
128MP0001661_extended_life_span0.81790939
129MP0002086_abnormal_extraembryonic_tissu0.81646626
130MP0000534_abnormal_ureter_morphology0.78742837
131MP0006292_abnormal_olfactory_placode0.78644215
132MP0005367_renal/urinary_system_phenotyp0.78549832
133MP0000516_abnormal_urinary_system0.78549832
134MP0003959_abnormal_lean_body0.78525874
135MP0002233_abnormal_nose_morphology0.78396474
136MP0001216_abnormal_epidermal_layer0.78105996
137MP0005084_abnormal_gallbladder_morpholo0.78076464
138MP0004272_abnormal_basement_membrane0.77747614
139MP0009703_decreased_birth_body0.77662946
140MP0005197_abnormal_uvea_morphology0.77256082

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)4.22758445
2Rib fusion (HP:0000902)4.18779455
3Hypoplastic ischia (HP:0003175)4.01526237
4Ankle contracture (HP:0006466)3.78512962
5Epiphyseal dysplasia (HP:0002656)3.65078805
6Abnormality of the ischium (HP:0003174)3.58094368
7Upper limb muscle weakness (HP:0003484)3.36576043
8Increased connective tissue (HP:0009025)3.36088093
9Long palpebral fissure (HP:0000637)3.17108802
10Abnormality of dentin (HP:0010299)3.11048711
11Hand muscle atrophy (HP:0009130)3.10517335
12Trismus (HP:0000211)3.09964512
13Premature rupture of membranes (HP:0001788)3.05868242
14Cervical subluxation (HP:0003308)3.04089921
15Follicular hyperkeratosis (HP:0007502)3.03238961
16Carpal bone hypoplasia (HP:0001498)3.00832369
17Protrusio acetabuli (HP:0003179)2.98107377
18Flat capital femoral epiphysis (HP:0003370)2.97421486
19Flat acetabular roof (HP:0003180)2.96072819
20Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.91064976
21Mildly elevated creatine phosphokinase (HP:0008180)2.88681177
22Testicular atrophy (HP:0000029)2.87504630
23Small epiphyses (HP:0010585)2.85045525
24Cupped ribs (HP:0000887)2.83295451
25Vitreoretinal degeneration (HP:0000655)2.82327523
26Progressive muscle weakness (HP:0003323)2.81479818
27Distal upper limb amyotrophy (HP:0007149)2.80679469
28Upper limb amyotrophy (HP:0009129)2.80679469
29Hyperinsulinemic hypoglycemia (HP:0000825)2.77123342
30Neonatal short-limb short stature (HP:0008921)2.76154579
31Nonimmune hydrops fetalis (HP:0001790)2.70966212
32Hepatoblastoma (HP:0002884)2.65427487
33Abnormality of the umbilical cord (HP:0010881)2.65397017
34Bladder diverticulum (HP:0000015)2.62727669
35Redundant skin (HP:0001582)2.62712228
36Abnormality of the pubic bones (HP:0003172)2.62261533
37Flattened epiphyses (HP:0003071)2.61765027
38Ulnar deviation of the wrist (HP:0003049)2.58443075
39Pterygium (HP:0001059)2.56825874
40Fragile skin (HP:0001030)2.56210960
41Abnormal tarsal ossification (HP:0008369)2.54767843
42Glossoptosis (HP:0000162)2.51638444
43Bilateral microphthalmos (HP:0007633)2.51274665
44Multiple enchondromatosis (HP:0005701)2.47027361
45Atrophic scars (HP:0001075)2.45074312
46Selective tooth agenesis (HP:0001592)2.44822443
47Fused cervical vertebrae (HP:0002949)2.43849567
48Myopathic facies (HP:0002058)2.40615372
49Thoracolumbar scoliosis (HP:0002944)2.38378887
50Abnormal cartilage morphology (HP:0002763)2.38307543
51Type 1 muscle fiber predominance (HP:0003803)2.36581802
52Deformed tarsal bones (HP:0008119)2.36349934
53Metaphyseal cupping (HP:0003021)2.36287904
54Absent eyelashes (HP:0000561)2.34104211
55Insomnia (HP:0100785)2.33925385
56Soft skin (HP:0000977)2.31391998
57Abnormality of the calcaneus (HP:0008364)2.30719939
58Abnormality of the intrinsic pathway (HP:0010989)2.30412609
59Elbow flexion contracture (HP:0002987)2.29649984
60Slender build (HP:0001533)2.27097726
61Bowel diverticulosis (HP:0005222)2.26085430
62Decreased subcutaneous fat (HP:0001002)2.24002290
63Osteoarthritis (HP:0002758)2.23435554
64Hypoventilation (HP:0002791)2.22725896
65Premature skin wrinkling (HP:0100678)2.20894022
66Shallow orbits (HP:0000586)2.19151207
67Hypoplasia of the pons (HP:0012110)2.18921602
68Exercise-induced muscle cramps (HP:0003710)2.18163649
69Joint stiffness (HP:0001387)2.14990852
70Hypoplastic scapulae (HP:0000882)2.14217882
71Aplasia/Hypoplasia of the scapulae (HP:0006713)2.14217882
72Aplasia/hypoplasia of the humerus (HP:0006507)2.13593046
73Abnormality of the lower motor neuron (HP:0002366)2.13515494
74Hyperacusis (HP:0010780)2.13318202
75Thin ribs (HP:0000883)2.13160033
76Abnormality of the labia minora (HP:0012880)2.12097263
77Difficulty climbing stairs (HP:0003551)2.12055186
78Mild short stature (HP:0003502)2.10468229
79Reticulocytopenia (HP:0001896)2.10343554
80Generalized amyotrophy (HP:0003700)2.10314137
81Difficulty running (HP:0009046)2.09983338
82Short humerus (HP:0005792)2.09478054
83Round ear (HP:0100830)2.07314800
84Large hands (HP:0001176)2.06766038
85Breech presentation (HP:0001623)2.05966372
86Severe short stature (HP:0003510)2.05637264
87Long foot (HP:0001833)2.04511306
88Spastic diplegia (HP:0001264)2.03668818
89Ulnar bowing (HP:0003031)2.02256702
90Genu varum (HP:0002970)2.01691945
91Achilles tendon contracture (HP:0001771)2.01367177
92Biconcave vertebral bodies (HP:0004586)2.01192856
93Hydroureter (HP:0000072)2.00995473
94Abnormal gallbladder physiology (HP:0012438)2.00144950
95Cholecystitis (HP:0001082)2.00144950
96Abnormality of subcutaneous fat tissue (HP:0001001)1.99502835
97Fragile nails (HP:0001808)1.99039199
98Squamous cell carcinoma (HP:0002860)1.98906254
99Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.98823740
100Abnormal number of incisors (HP:0011064)1.98034151
101Abnormal foot bone ossification (HP:0010675)1.97865281
102Muscle fiber inclusion bodies (HP:0100299)1.96917626
103Abnormal vertebral ossification (HP:0100569)1.96642124
104Abnormality of the distal phalanges of the toes (HP:0010182)1.94373064
105Cortical dysplasia (HP:0002539)1.94235421
106Radial bowing (HP:0002986)1.93798567
107Vertebral fusion (HP:0002948)1.92480603
108Back pain (HP:0003418)1.91584258
109Abdominal situs inversus (HP:0003363)1.91553948
110Abnormality of abdominal situs (HP:0011620)1.91553948
111Abnormality of the fetal cardiovascular system (HP:0010948)1.91440151
112Abnormal umbilical cord blood vessels (HP:0011403)1.91440151
113Single umbilical artery (HP:0001195)1.91440151
114Arthropathy (HP:0003040)1.91358298
115Rough bone trabeculation (HP:0100670)1.90325591
116Mesomelia (HP:0003027)1.89185386
117Abnormality of the odontoid process (HP:0003310)1.89125963
118Vertebral compression fractures (HP:0002953)1.89118329
119Spinal cord compression (HP:0002176)1.88739455
120Hyperextensible skin (HP:0000974)1.88390405
121Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.88023692
122Breast hypoplasia (HP:0003187)1.87306372
123Distal lower limb muscle weakness (HP:0009053)1.87283283
124Peritonitis (HP:0002586)1.87237181
125Hypoplasia of the odontoid process (HP:0003311)1.86717283
126Platyspondyly (HP:0000926)1.86603003
127Partial duplication of thumb phalanx (HP:0009944)1.85229861
128Overriding aorta (HP:0002623)1.84677419
129Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.83617466
130Vertebral hypoplasia (HP:0008417)1.83617466
131Calcaneovalgus deformity (HP:0001848)1.83506931
132Abnormality of the pons (HP:0007361)1.83447336
133Genu recurvatum (HP:0002816)1.83367789
134Shawl scrotum (HP:0000049)1.81098681
135Protruding ear (HP:0000411)1.79785718
136Disproportionate tall stature (HP:0001519)1.78407226
137Duplication of thumb phalanx (HP:0009942)1.78185967
138Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.77757136
139Abnormality of femoral epiphyses (HP:0006499)1.77757136
140Distal arthrogryposis (HP:0005684)1.77494516
141Deep palmar crease (HP:0006191)1.77453528
142Vertebral clefting (HP:0008428)1.77326864
143Partial duplication of the phalanx of hand (HP:0009999)1.77119859
144Ependymoma (HP:0002888)1.76761051
145Abnormalities of placenta or umbilical cord (HP:0001194)1.75795726
146Renal duplication (HP:0000075)1.75470803
147Abnormality of the pancreatic islet cells (HP:0006476)1.75464261
148Abnormality of endocrine pancreas physiology (HP:0012093)1.75464261
149Generalized hypotonia (HP:0001290)1.75457326
150Horseshoe kidney (HP:0000085)1.75252625
151Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.73026125
152Increased variability in muscle fiber diameter (HP:0003557)1.72951653
153Spinal muscular atrophy (HP:0007269)1.72823299
154Abnormality of the acetabulum (HP:0003170)1.72442762
155Abnormality of the Achilles tendon (HP:0005109)1.72309689
156Blue sclerae (HP:0000592)1.72205564
157Spinal rigidity (HP:0003306)1.71734886
158Patent foramen ovale (HP:0001655)1.71730082
159Limb-girdle muscle weakness (HP:0003325)1.71431306
160Natal tooth (HP:0000695)1.70548451
161Congenital glaucoma (HP:0001087)1.69224656
162Poor suck (HP:0002033)1.67895053
163Abnormal ventriculo-arterial connection (HP:0011563)1.66344800
164Transposition of the great arteries (HP:0001669)1.66344800
165Abnormal connection of the cardiac segments (HP:0011545)1.66344800
166Deviation of the hallux (HP:0010051)1.65653791
167Entropion (HP:0000621)1.65289997
168Congenital hip dislocation (HP:0001374)1.65031765
169Prominent metopic ridge (HP:0005487)1.64107635
170Birth length less than 3rd percentile (HP:0003561)1.63024574
171Congenital ichthyosiform erythroderma (HP:0007431)1.62484100
172Coronal craniosynostosis (HP:0004440)1.62415544
173Hypokinesia (HP:0002375)1.61183070
174Facial cleft (HP:0002006)1.58041699
175Aplasia/Hypoplasia of the sacrum (HP:0008517)1.57785473

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN17.15184016
2CDK124.62850772
3LATS24.58822976
4EPHA23.33352140
5VRK23.02284752
6SMG12.98394614
7GRK52.54278876
8BCKDK2.42536956
9CDC72.37307215
10TRIB32.29686295
11DDR22.16232620
12EIF2AK32.14373773
13MAP3K32.11796737
14ARAF2.07539148
15AKT32.07525254
16ICK2.03391036
17PBK1.98812810
18NME11.87528957
19LMTK21.86873205
20GRK61.85932632
21STK161.85857906
22MYLK1.80408693
23TTN1.72449933
24IRAK31.66345701
25MAPKAPK31.65047692
26TAF11.60826091
27PAK41.59230060
28LIMK11.45177348
29TRIM281.38220765
30PASK1.37458890
31LATS11.33570132
32MOS1.33121432
33DAPK31.31717256
34SRPK11.31089014
35RPS6KB21.28044286
36TTK1.27412471
37EIF2AK11.18499959
38SCYL21.17601791
39EEF2K1.17005652
40NTRK11.15070253
41PLK31.14172510
42MST41.08398423
43PRKG21.06604943
44PKN21.04012577
45PDGFRA1.03635815
46MTOR1.03497016
47ALK1.03262719
48NEK10.99817750
49BRSK10.99639438
50ADRBK20.99148057
51CAMK1D0.98408486
52GRK10.96329002
53PDK20.95772048
54MAPK70.95034627
55EPHB20.93940232
56PRKD30.93917588
57NME20.93292014
58PTK20.92826771
59BMX0.92323186
60TAOK30.86348259
61ERBB40.84272443
62STK100.83959488
63CAMK1G0.83440596
64VRK10.83415192
65PIK3CG0.82702818
66MET0.82589467
67MAP2K20.82215143
68WNK10.79930471
69BUB10.79740365
70PAK20.79140985
71BRD40.77258724
72PIM20.76966936
73PDK30.73824980
74PDK40.73824980
75STK38L0.73351843
76ABL20.72658990
77MAP2K30.72067919
78STK40.72061045
79HIPK20.70920052
80PRKCI0.70845345
81CDK80.69796880
82TYRO30.67909712
83CDK70.66131357
84TAOK10.64314694
85MAP3K80.63614210
86BCR0.63350612
87IRAK20.62529142
88DYRK20.61089005
89PLK10.60654437
90MAP2K40.59779093
91BRAF0.58860830
92FLT30.58722218
93CDK90.58661716
94FER0.58207614
95MAP3K100.57980548
96RPS6KA20.57340667
97AKT20.57321447
98ADRBK10.56744950
99KDR0.56234729
100PRPF4B0.56079937
101MAPK120.55963343
102SIK10.55777465
103PAK10.55680070
104MARK20.54801773
105STK240.54793712
106MAP3K110.54578146
107DAPK10.54536098
108AURKA0.54074369
109MATK0.53564435
110MAP2K10.53379620
111PRKD20.52325097
112INSRR0.51464931
113CSF1R0.50337447
114ZAK0.49036411
115TSSK60.48987497
116STK30.48939621
117TGFBR20.48775913
118CSNK1G30.48179369
119CHEK20.48153506
120TAOK20.47991861
121BRSK20.47528625
122CHEK10.47185565
123RPS6KA40.46340953
124TESK20.45982735
125DMPK0.45584963
126GRK70.44380583
127CSNK1A1L0.43004976
128ATR0.42759049
129WEE10.42635917
130CDK140.42587869
131FRK0.41785721
132CDK11A0.41631693
133ROCK20.40175642
134CSNK1G10.39938934
135CSNK1E0.39152928
136CDK180.38545846
137CDK150.37150095
138FGFR30.34971324
139TESK10.34946636
140PAK30.32818659
141MAP2K60.28693368
142DYRK1A0.27327582
143CAMK40.25970932
144MAPKAPK20.24864978
145OBSCN0.24833121
146MAP3K90.23632914
147CDK20.23483672
148AURKB0.22692542
149GSK3A0.22453668

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009704.42757588
2One carbon pool by folate_Homo sapiens_hsa006703.88645787
3Protein digestion and absorption_Homo sapiens_hsa049743.44423534
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.23581581
5Protein export_Homo sapiens_hsa030603.04551406
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.84525769
7Pancreatic secretion_Homo sapiens_hsa049722.83412693
8Vitamin B6 metabolism_Homo sapiens_hsa007502.72752444
9Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.47371400
10DNA replication_Homo sapiens_hsa030302.46463263
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.45206419
12Fat digestion and absorption_Homo sapiens_hsa049752.44591328
13Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39367166
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.26922775
15Fructose and mannose metabolism_Homo sapiens_hsa000512.24881307
16Mismatch repair_Homo sapiens_hsa034302.09409278
17Folate biosynthesis_Homo sapiens_hsa007901.84877820
18Biosynthesis of amino acids_Homo sapiens_hsa012301.75895107
19Basal transcription factors_Homo sapiens_hsa030221.72515456
20Bladder cancer_Homo sapiens_hsa052191.70533795
21Base excision repair_Homo sapiens_hsa034101.70173287
22mTOR signaling pathway_Homo sapiens_hsa041501.63246823
23Galactose metabolism_Homo sapiens_hsa000521.62385274
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.60614622
25Sulfur relay system_Homo sapiens_hsa041221.55579211
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53460743
27Pyrimidine metabolism_Homo sapiens_hsa002401.53445167
28Selenocompound metabolism_Homo sapiens_hsa004501.50608584
29RNA transport_Homo sapiens_hsa030131.43214495
30Nucleotide excision repair_Homo sapiens_hsa034201.37955888
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37813552
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.33696049
33Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.33142953
34Spliceosome_Homo sapiens_hsa030401.33078365
35Linoleic acid metabolism_Homo sapiens_hsa005911.32961969
36Vibrio cholerae infection_Homo sapiens_hsa051101.24159046
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.22756456
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.22362072
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21126279
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16839469
41Central carbon metabolism in cancer_Homo sapiens_hsa052301.14318867
42Ribosome_Homo sapiens_hsa030101.11735474
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10607593
44Thyroid cancer_Homo sapiens_hsa052161.05798761
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00189707
46p53 signaling pathway_Homo sapiens_hsa041150.99616916
47Melanoma_Homo sapiens_hsa052180.97702014
48RNA degradation_Homo sapiens_hsa030180.96032314
49ECM-receptor interaction_Homo sapiens_hsa045120.94575577
50Fanconi anemia pathway_Homo sapiens_hsa034600.93790644
51Arachidonic acid metabolism_Homo sapiens_hsa005900.93455661
52Carbon metabolism_Homo sapiens_hsa012000.93286127
53Non-homologous end-joining_Homo sapiens_hsa034500.91380566
54Steroid biosynthesis_Homo sapiens_hsa001000.91323043
55Homologous recombination_Homo sapiens_hsa034400.90462339
56Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90042222
57Wnt signaling pathway_Homo sapiens_hsa043100.88401100
58Pentose phosphate pathway_Homo sapiens_hsa000300.88227238
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77775095
60Fatty acid elongation_Homo sapiens_hsa000620.77573128
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.76818997
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.75625813
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74838261
64Arginine and proline metabolism_Homo sapiens_hsa003300.74756825
65Huntingtons disease_Homo sapiens_hsa050160.72612445
66Proteoglycans in cancer_Homo sapiens_hsa052050.71493481
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70643777
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68239978
69Proteasome_Homo sapiens_hsa030500.68007459
70Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67943148
71Focal adhesion_Homo sapiens_hsa045100.66232302
72Insulin resistance_Homo sapiens_hsa049310.66137815
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65874597
74HIF-1 signaling pathway_Homo sapiens_hsa040660.65262259
75Glucagon signaling pathway_Homo sapiens_hsa049220.64857665
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63526893
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62980278
78Purine metabolism_Homo sapiens_hsa002300.62715830
79Other glycan degradation_Homo sapiens_hsa005110.62319884
80Arginine biosynthesis_Homo sapiens_hsa002200.62180393
81Melanogenesis_Homo sapiens_hsa049160.61756066
82Hippo signaling pathway_Homo sapiens_hsa043900.61434718
83Parkinsons disease_Homo sapiens_hsa050120.60754525
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58906469
85Insulin signaling pathway_Homo sapiens_hsa049100.58118252
86Shigellosis_Homo sapiens_hsa051310.57924021
87AMPK signaling pathway_Homo sapiens_hsa041520.57365044
88Oxidative phosphorylation_Homo sapiens_hsa001900.56736787
89Basal cell carcinoma_Homo sapiens_hsa052170.56733593
90Glycerolipid metabolism_Homo sapiens_hsa005610.56441886
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.55828177
92Glutathione metabolism_Homo sapiens_hsa004800.54801205
93Prostate cancer_Homo sapiens_hsa052150.54222670
94N-Glycan biosynthesis_Homo sapiens_hsa005100.53487805
95MicroRNAs in cancer_Homo sapiens_hsa052060.52245915
96Notch signaling pathway_Homo sapiens_hsa043300.52201880
97Oocyte meiosis_Homo sapiens_hsa041140.51116947
98Legionellosis_Homo sapiens_hsa051340.50853891
99Starch and sucrose metabolism_Homo sapiens_hsa005000.50573641
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50518196
101Adherens junction_Homo sapiens_hsa045200.49679526
102Acute myeloid leukemia_Homo sapiens_hsa052210.49305092
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49085852
104Hedgehog signaling pathway_Homo sapiens_hsa043400.46983907
105Pyruvate metabolism_Homo sapiens_hsa006200.46191792
106RNA polymerase_Homo sapiens_hsa030200.45644535
107Insulin secretion_Homo sapiens_hsa049110.45545539
108Apoptosis_Homo sapiens_hsa042100.45223217
109Sulfur metabolism_Homo sapiens_hsa009200.44000812
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.43776890
111TGF-beta signaling pathway_Homo sapiens_hsa043500.42627519
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.42252992
113Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40343165
114Axon guidance_Homo sapiens_hsa043600.38752533
115Viral carcinogenesis_Homo sapiens_hsa052030.38419786
116Small cell lung cancer_Homo sapiens_hsa052220.38109877
117Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.36768506
118Prion diseases_Homo sapiens_hsa050200.35110478
119Glioma_Homo sapiens_hsa052140.34905215
120Chronic myeloid leukemia_Homo sapiens_hsa052200.33801711
121Renin-angiotensin system_Homo sapiens_hsa046140.33617940
122Tight junction_Homo sapiens_hsa045300.33223514
123Dilated cardiomyopathy_Homo sapiens_hsa054140.32629474
124Synaptic vesicle cycle_Homo sapiens_hsa047210.30027933
125Pathways in cancer_Homo sapiens_hsa052000.29818744
126Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29713390
127Cell cycle_Homo sapiens_hsa041100.29411590
128Non-small cell lung cancer_Homo sapiens_hsa052230.27051558
129Rap1 signaling pathway_Homo sapiens_hsa040150.25966607
130Endometrial cancer_Homo sapiens_hsa052130.25706827
131HTLV-I infection_Homo sapiens_hsa051660.22702251
132Lysosome_Homo sapiens_hsa041420.22369393
133mRNA surveillance pathway_Homo sapiens_hsa030150.22040547
134VEGF signaling pathway_Homo sapiens_hsa043700.21775144
135Ras signaling pathway_Homo sapiens_hsa040140.21561882
136Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21482287
137MAPK signaling pathway_Homo sapiens_hsa040100.21223563
138Type I diabetes mellitus_Homo sapiens_hsa049400.20025394
139Metabolic pathways_Homo sapiens_hsa011000.18199159

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