CFL1P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)5.91741972
2Arp2/3 complex-mediated actin nucleation (GO:0034314)5.45789930
3protein maturation by protein folding (GO:0022417)5.30118662
4DNA deamination (GO:0045006)4.75718387
5actin nucleation (GO:0045010)4.66141966
6response to interferon-beta (GO:0035456)4.48311672
7regulation of cellular amino acid metabolic process (GO:0006521)4.45578692
8positive regulation of actin filament depolymerization (GO:0030836)4.37763174
9positive regulation of interleukin-8 secretion (GO:2000484)4.25927332
10DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.20392553
11viral mRNA export from host cell nucleus (GO:0046784)4.19160519
12negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.17978360
13negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.15901924
14protein neddylation (GO:0045116)4.12256636
15deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.11021908
16platelet dense granule organization (GO:0060155)4.09630015
17signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.07239626
18intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.07239626
19signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.04443680
20signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.04443680
21signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.04443680
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.04100971
23establishment of integrated proviral latency (GO:0075713)3.98251924
24signal transduction involved in DNA damage checkpoint (GO:0072422)3.92053492
25signal transduction involved in DNA integrity checkpoint (GO:0072401)3.92053492
26signal transduction involved in cell cycle checkpoint (GO:0072395)3.91555405
27positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.86379174
28regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.81855963
29ATP synthesis coupled proton transport (GO:0015986)3.80980687
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.80980687
31regulation of interleukin-8 secretion (GO:2000482)3.80281209
32antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.79353078
33proteasome assembly (GO:0043248)3.78711949
34establishment of viral latency (GO:0019043)3.77463254
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.71726868
36negative regulation of ligase activity (GO:0051352)3.71726868
37cellular response to interferon-beta (GO:0035458)3.61901400
38antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.56825367
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53716059
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.53415208
41protein deneddylation (GO:0000338)3.43950335
42negative regulation of calcium ion transport into cytosol (GO:0010523)3.40577920
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34953862
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34953862
45cytidine deamination (GO:0009972)3.34240569
46cytidine metabolic process (GO:0046087)3.34240569
47cytidine catabolic process (GO:0006216)3.34240569
48anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.31793018
49negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.30277152
50response to gravity (GO:0009629)3.29268427
51positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.28111360
52DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.27838336
53electron transport chain (GO:0022900)3.27318912
54respiratory electron transport chain (GO:0022904)3.26971225
55cullin deneddylation (GO:0010388)3.22852162
56positive regulation of ligase activity (GO:0051351)3.20088269
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.17715526
58regulation of cellular amine metabolic process (GO:0033238)3.16198059
59antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.13614226
60nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.04956658
61water-soluble vitamin biosynthetic process (GO:0042364)3.03894859
62adenosine metabolic process (GO:0046085)3.01982879
63positive regulation of cell cycle arrest (GO:0071158)3.00999997
64interferon-gamma secretion (GO:0072643)2.99169696
65positive regulation of defense response to virus by host (GO:0002230)2.97805865
66protein complex biogenesis (GO:0070271)2.94845687
67positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.92286613
68nucleotide transmembrane transport (GO:1901679)2.88930272
69positive regulation of mitochondrial fission (GO:0090141)2.88062449
70ubiquinone biosynthetic process (GO:0006744)2.84744270
71negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.80573499
72metallo-sulfur cluster assembly (GO:0031163)2.77896276
73iron-sulfur cluster assembly (GO:0016226)2.77896276
74positive regulation of lamellipodium assembly (GO:0010592)2.76297586
75signal transduction in response to DNA damage (GO:0042770)2.75295666
76antigen processing and presentation via MHC class Ib (GO:0002475)2.72937149
77GPI anchor biosynthetic process (GO:0006506)2.70909072
78chaperone-mediated protein transport (GO:0072321)2.68430262
79negative regulation of cation channel activity (GO:2001258)2.68039994
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.67404912
81NADH dehydrogenase complex assembly (GO:0010257)2.67404912
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.67404912
83response to xenobiotic stimulus (GO:0009410)2.66767189
84negative regulation of protein ubiquitination (GO:0031397)2.64261884
85regulation of cell cycle arrest (GO:0071156)2.63731977
86mitochondrial respiratory chain complex assembly (GO:0033108)2.63076384
87detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.63063554
88exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.62571509
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.61462628
90sulfation (GO:0051923)2.60964229
91protein targeting to mitochondrion (GO:0006626)2.60018419
92regulation of ubiquitin-protein transferase activity (GO:0051438)2.59970646
93regulation of protein kinase A signaling (GO:0010738)2.58571199
94ubiquinone metabolic process (GO:0006743)2.57822676
95RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.57731697
96pyrimidine ribonucleoside catabolic process (GO:0046133)2.57724549
97regulation of ligase activity (GO:0051340)2.56331416
98cellular response to exogenous dsRNA (GO:0071360)2.54437957
99positive regulation of TOR signaling (GO:0032008)2.53337854
100transcription elongation from RNA polymerase III promoter (GO:0006385)2.52851537

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.87487113
2ELF1_17652178_ChIP-ChIP_JURKAT_Human4.24582507
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.20111955
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.81021465
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.49321546
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.41690500
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.17411691
8VDR_23849224_ChIP-Seq_CD4+_Human2.97238109
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71953538
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.70745439
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.69261823
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.68262118
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64318259
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.58597274
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.55346294
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43828337
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.38445438
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35055289
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29491464
20VDR_22108803_ChIP-Seq_LS180_Human2.25135301
21ELK1_19687146_ChIP-ChIP_HELA_Human2.14196587
22FOXP3_21729870_ChIP-Seq_TREG_Human2.11200386
23BP1_19119308_ChIP-ChIP_Hs578T_Human2.02969460
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01749427
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97484616
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.95312227
27IGF1R_20145208_ChIP-Seq_DFB_Human1.89031348
28GABP_19822575_ChIP-Seq_HepG2_Human1.88115295
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86869866
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79533320
31CIITA_25753668_ChIP-Seq_RAJI_Human1.79137554
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.74241500
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.71410494
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69928340
35ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.69111270
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.68992214
37HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61151440
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60727954
39DCP1A_22483619_ChIP-Seq_HELA_Human1.58313780
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54264848
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53848227
42MYB_26560356_Chip-Seq_TH2_Human1.50529702
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.49404902
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.49301601
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43473204
46GATA3_26560356_Chip-Seq_TH2_Human1.40933522
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38306945
48PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.33403350
49CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.32617430
50ZNF274_21170338_ChIP-Seq_K562_Hela1.31898970
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29766841
52EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.27412782
53RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24800873
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.22316826
55SPI1_23547873_ChIP-Seq_NB4_Human1.21676115
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20010556
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.19932075
58RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.18775363
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17887667
60MYC_18555785_ChIP-Seq_MESCs_Mouse1.17461678
61FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17014706
62MYC_18940864_ChIP-ChIP_HL60_Human1.13234676
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12198201
64GATA3_27048872_Chip-Seq_THYMUS_Human1.09754714
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08971622
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.08971622
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08332861
68THAP11_20581084_ChIP-Seq_MESCs_Mouse1.07578749
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05370222
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05099068
71AR_20517297_ChIP-Seq_VCAP_Human1.04526547
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03435940
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03054706
74TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02734096
75NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02582312
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.02483524
77CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.01939848
78EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01483565
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01183302
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01002419
81ERG_20517297_ChIP-Seq_VCAP_Human0.99579614
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99011903
83AUTS2_25519132_ChIP-Seq_293T-REX_Human0.98012271
84EWS_26573619_Chip-Seq_HEK293_Human0.97119234
85BCL6_27268052_Chip-Seq_Bcells_Human0.96715934
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.93666995
87ERA_21632823_ChIP-Seq_H3396_Human0.89001587
88LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88789204
89CBP_20019798_ChIP-Seq_JUKART_Human0.88279473
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88279473
91NCOR_22424771_ChIP-Seq_293T_Human0.88193203
92P300_27268052_Chip-Seq_Bcells_Human0.86442385
93TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.85667113
94ELF5_23300383_ChIP-Seq_T47D_Human0.85369976
95FOXH1_21741376_ChIP-Seq_EPCs_Human0.84716042
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84487688
97HOXB7_26014856_ChIP-Seq_BT474_Human0.83490164
98GATA3_26560356_Chip-Seq_TH1_Human0.83287872
99NANOG_20526341_ChIP-Seq_ESCs_Human0.83166104
100STAT1_20625510_ChIP-Seq_HELA_Human0.82246129

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level3.59551088
2MP0001835_abnormal_antigen_presentation3.50448922
3MP0005671_abnormal_response_to3.09971109
4MP0002166_altered_tumor_susceptibility2.82330039
5MP0002102_abnormal_ear_morphology2.74289162
6MP0001905_abnormal_dopamine_level2.53003207
7MP0009764_decreased_sensitivity_to2.50660792
8MP0002006_tumorigenesis2.47907941
9MP0000685_abnormal_immune_system2.39058595
10MP0006072_abnormal_retinal_apoptosis2.35873689
11MP0005084_abnormal_gallbladder_morpholo2.35253643
12MP0003724_increased_susceptibility_to2.35229666
13MP0009785_altered_susceptibility_to2.27637156
14MP0003786_premature_aging2.22776709
15MP0002148_abnormal_hypersensitivity_rea2.17251084
16MP0008875_abnormal_xenobiotic_pharmacok2.05883722
17MP0002837_dystrophic_cardiac_calcinosis2.02856279
18MP0001542_abnormal_bone_strength1.95622508
19MP0005083_abnormal_biliary_tract1.86719122
20MP0003191_abnormal_cellular_cholesterol1.83800722
21MP0006035_abnormal_mitochondrial_morpho1.80451631
22MP0008872_abnormal_physiological_respon1.73356692
23MP0003646_muscle_fatigue1.70557774
24MP0003123_paternal_imprinting1.70436537
25MP0004885_abnormal_endolymph1.62026698
26MP0001800_abnormal_humoral_immune1.61204032
27MP0001968_abnormal_touch/_nociception1.55669561
28MP0002723_abnormal_immune_serum1.52580184
29MP0002452_abnormal_antigen_presenting1.52202544
30MP0003075_altered_response_to1.52073072
31MP0005000_abnormal_immune_tolerance1.47185271
32MP0001853_heart_inflammation1.43310236
33MP0001819_abnormal_immune_cell1.41777418
34MP0002420_abnormal_adaptive_immunity1.40100905
35MP0005025_abnormal_response_to1.39748480
36MP0002138_abnormal_hepatobiliary_system1.37977665
37MP0002736_abnormal_nociception_after1.37082475
38MP0006036_abnormal_mitochondrial_physio1.36683026
39MP0009697_abnormal_copulation1.32219641
40MP0003195_calcinosis1.30793312
41MP0003183_abnormal_peptide_metabolism1.30319134
42MP0001529_abnormal_vocalization1.27512826
43MP0005464_abnormal_platelet_physiology1.27460182
44MP0001188_hyperpigmentation1.21610694
45MP0008775_abnormal_heart_ventricle1.20642135
46MP0001790_abnormal_immune_system1.20098246
47MP0005387_immune_system_phenotype1.20098246
48MP0000343_altered_response_to1.18957473
49MP0005167_abnormal_blood-brain_barrier1.18897895
50MP0003866_abnormal_defecation1.12854009
51MP0003011_delayed_dark_adaptation1.12105647
52MP0005646_abnormal_pituitary_gland1.10708507
53MP0005165_increased_susceptibility_to1.09674280
54MP0008058_abnormal_DNA_repair1.09649316
55MP0003436_decreased_susceptibility_to1.09009336
56MP0009780_abnormal_chondrocyte_physiolo1.08805784
57MP0002095_abnormal_skin_pigmentation1.05651404
58MP0008260_abnormal_autophagy1.04040517
59MP0000858_altered_metastatic_potential1.03679443
60MP0002272_abnormal_nervous_system1.03521597
61MP0000751_myopathy1.02304425
62MP0005253_abnormal_eye_physiology1.02165155
63MP0003950_abnormal_plasma_membrane1.01691588
64MP0001243_abnormal_dermal_layer1.01660242
65MP0002419_abnormal_innate_immunity1.00688110
66MP0002332_abnormal_exercise_endurance1.00664692
67MP0004145_abnormal_muscle_electrophysio0.98218090
68MP0000749_muscle_degeneration0.96840812
69MP0002722_abnormal_immune_system0.96161249
70MP0000689_abnormal_spleen_morphology0.95601812
71MP0000358_abnormal_cell_content/0.94898989
72MP0000716_abnormal_immune_system0.94801134
73MP0008877_abnormal_DNA_methylation0.94229963
74MP0000613_abnormal_salivary_gland0.93888551
75MP0002282_abnormal_trachea_morphology0.92338738
76MP0000516_abnormal_urinary_system0.91702071
77MP0005367_renal/urinary_system_phenotyp0.91702071
78MP0000465_gastrointestinal_hemorrhage0.91497418
79MP0005389_reproductive_system_phenotype0.90264029
80MP0003638_abnormal_response/metabolism_0.87566081
81MP0008007_abnormal_cellular_replicative0.86589535
82MP0003186_abnormal_redox_activity0.85770957
83MP0003880_abnormal_central_pattern0.85676162
84MP0005166_decreased_susceptibility_to0.85629778
85MP0002933_joint_inflammation0.85144498
86MP0000372_irregular_coat_pigmentation0.84609272
87MP0001845_abnormal_inflammatory_respons0.84108680
88MP0003718_maternal_effect0.81032116
89MP0000639_abnormal_adrenal_gland0.80910292
90MP0002429_abnormal_blood_cell0.80675697
91MP0003806_abnormal_nucleotide_metabolis0.80134340
92MP0010155_abnormal_intestine_physiology0.79302201
93MP0009763_increased_sensitivity_to0.78837698
94MP0002398_abnormal_bone_marrow0.78730729
95MP0001533_abnormal_skeleton_physiology0.78395037
96MP0009333_abnormal_splenocyte_physiolog0.77329617
97MP0005410_abnormal_fertilization0.76561130
98MP0002177_abnormal_outer_ear0.76349564
99MP0001919_abnormal_reproductive_system0.75721162
100MP0005636_abnormal_mineral_homeostasis0.75642716

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.88261933
2Hepatocellular necrosis (HP:0001404)4.40158401
3Hepatic necrosis (HP:0002605)4.34694522
4IgG deficiency (HP:0004315)4.26440409
5Mitochondrial inheritance (HP:0001427)3.86781354
6Increased CSF lactate (HP:0002490)3.49907795
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.47292254
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.47292254
9Acute necrotizing encephalopathy (HP:0006965)3.46601322
103-Methylglutaconic aciduria (HP:0003535)3.27738074
11Abnormal mitochondria in muscle tissue (HP:0008316)3.26510224
12Abnormality of alanine metabolism (HP:0010916)3.15816127
13Hyperalaninemia (HP:0003348)3.15816127
14Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.15816127
15Short tibia (HP:0005736)3.03269196
16Type I transferrin isoform profile (HP:0003642)2.99195413
17Generalized aminoaciduria (HP:0002909)2.98200045
18Increased serum lactate (HP:0002151)2.96305991
19Acute encephalopathy (HP:0006846)2.95369603
20Abolished electroretinogram (ERG) (HP:0000550)2.94089628
21Lactic acidosis (HP:0003128)2.88749783
22Increased IgM level (HP:0003496)2.85789759
23Cerebral palsy (HP:0100021)2.84471004
24Progressive macrocephaly (HP:0004481)2.77759275
25Conjunctival hamartoma (HP:0100780)2.77347229
26Adrenal hypoplasia (HP:0000835)2.74586726
27Reduced subcutaneous adipose tissue (HP:0003758)2.66663784
28Aplasia/Hypoplasia of the tibia (HP:0005772)2.63964577
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.62973961
30Absent rod-and cone-mediated responses on ERG (HP:0007688)2.56370508
31Glucose intolerance (HP:0000833)2.51053716
32Abnormality of the prostate (HP:0008775)2.51050739
33Reduced antithrombin III activity (HP:0001976)2.47385020
34Facial diplegia (HP:0001349)2.40832772
35Stomatitis (HP:0010280)2.40070926
36Congenital, generalized hypertrichosis (HP:0004540)2.38688846
37Hypoproteinemia (HP:0003075)2.34241612
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.33507296
39Prostate neoplasm (HP:0100787)2.29524113
40Fibular aplasia (HP:0002990)2.29397057
41Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25089985
42Dicarboxylic aciduria (HP:0003215)2.25089985
43Respiratory failure (HP:0002878)2.20139241
44Cerebral edema (HP:0002181)2.19443301
45Abnormality of the phalanges of the 2nd finger (HP:0009541)2.18109843
46Decreased central vision (HP:0007663)2.14481357
47Methylmalonic acidemia (HP:0002912)2.11662128
48Microretrognathia (HP:0000308)2.11227900
49Molar tooth sign on MRI (HP:0002419)2.10520726
50Abnormality of midbrain morphology (HP:0002418)2.10520726
51Pulmonary fibrosis (HP:0002206)2.09536256
52Emotional lability (HP:0000712)2.09103482
53Increased hepatocellular lipid droplets (HP:0006565)2.08958074
54Rough bone trabeculation (HP:0100670)2.06013728
55Myositis (HP:0100614)2.04914521
56Exercise intolerance (HP:0003546)2.03978790
57Oral leukoplakia (HP:0002745)2.02179369
58Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.01303361
59Abnormal protein N-linked glycosylation (HP:0012347)2.01303361
60Abnormal protein glycosylation (HP:0012346)2.01303361
61Abnormal glycosylation (HP:0012345)2.01303361
62Attenuation of retinal blood vessels (HP:0007843)1.99907318
63Vertebral compression fractures (HP:0002953)1.99682903
64Erythema (HP:0010783)1.95943648
65Optic disc pallor (HP:0000543)1.95736935
66Acute hepatic failure (HP:0006554)1.95333614
67Nausea (HP:0002018)1.94038996
68Pancytopenia (HP:0001876)1.93338348
69CNS demyelination (HP:0007305)1.91396329
70Renal Fanconi syndrome (HP:0001994)1.90775966
71Methylmalonic aciduria (HP:0012120)1.89728403
72Severe combined immunodeficiency (HP:0004430)1.89342301
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.89067563
74Abnormal rod and cone electroretinograms (HP:0008323)1.88554748
75Pustule (HP:0200039)1.84724458
76Palpitations (HP:0001962)1.84605891
77Rhabdomyolysis (HP:0003201)1.83592462
78Palpebral edema (HP:0100540)1.83556948
79Spastic paraparesis (HP:0002313)1.83180591
80Aplastic anemia (HP:0001915)1.82780507
81Hypoplastic pelvis (HP:0008839)1.81805974
82Entropion (HP:0000621)1.80942628
83Dynein arm defect of respiratory motile cilia (HP:0012255)1.80874573
84Absent/shortened dynein arms (HP:0200106)1.80874573
85Congenital stationary night blindness (HP:0007642)1.80681660
86Severe visual impairment (HP:0001141)1.80626699
87Sparse eyelashes (HP:0000653)1.79500677
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78644049
89Lipid accumulation in hepatocytes (HP:0006561)1.75870106
90Progressive inability to walk (HP:0002505)1.75060229
91IgM deficiency (HP:0002850)1.74242151
92Chronic sinusitis (HP:0011109)1.74164265
93Bone cyst (HP:0012062)1.73560685
94Growth hormone excess (HP:0000845)1.73003352
95Aplasia/hypoplasia of the uterus (HP:0008684)1.70410620
96Short femoral neck (HP:0100864)1.69279992
97Exertional dyspnea (HP:0002875)1.69090120
98Amyotrophic lateral sclerosis (HP:0007354)1.68348377
99Abnormality of the phalanges of the 5th finger (HP:0004213)1.66143250
100Lethargy (HP:0001254)1.65148590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK25.79151762
2VRK24.57215146
3TESK14.29070871
4LIMK13.74180846
5KDR3.53130807
6TIE13.25999090
7TAOK32.49553613
8NME22.36450588
9MAP3K122.30922380
10BCKDK2.29789892
11CSNK1G32.09686023
12MAP4K22.01716420
13CSNK1A1L1.97424586
14TLK11.82729453
15VRK11.73540459
16DAPK11.72394421
17BCR1.71167271
18TXK1.70937023
19PIM21.66871160
20GRK11.65161467
21BUB11.60273630
22CSNK1G21.57601764
23ERBB31.55059101
24CSNK1G11.54296361
25ADRBK21.40628591
26NUAK11.39102981
27CDK81.34079451
28MAPKAPK31.28353614
29STK161.22834832
30CCNB11.20611059
31EPHA21.17401757
32NEK11.14599153
33SRPK11.13350020
34MYLK1.10632773
35ARAF1.03306789
36ZAK0.99437719
37MAP2K70.92820389
38TEC0.92196968
39TRIM280.87729309
40RPS6KA40.85402083
41CSF1R0.83715139
42RPS6KA50.82620831
43PHKG10.81330162
44PHKG20.81330162
45TBK10.79915084
46SCYL20.79778156
47MAP4K10.75657985
48ZAP700.72139630
49PINK10.71320845
50GRK50.70193387
51LMTK20.69710481
52PTK2B0.64205036
53KIT0.55102269
54MST1R0.54280866
55WNK40.53761444
56IKBKB0.52938415
57ITK0.50907503
58FLT30.50740810
59IRAK30.50266548
60GRK60.49572288
61DAPK30.48470654
62SIK30.48086833
63WNK30.46540485
64PAK10.45991721
65IKBKE0.45691504
66MAPK130.44893448
67SYK0.44154823
68ABL20.43967867
69EIF2AK10.43954904
70MST40.43217228
71MINK10.42640607
72EIF2AK20.42154952
73PRKCE0.40985955
74DYRK20.38684877
75BLK0.37932298
76INSRR0.37601575
77DAPK20.36645284
78AURKA0.36433426
79MAP3K140.36341647
80EGFR0.34838114
81TAF10.34631497
82PLK30.34208735
83EIF2AK30.33955123
84CSNK1A10.33819370
85PLK20.33451946
86TNK20.32828866
87CSNK2A10.32420069
88PRKCI0.31824406
89IGF1R0.31487869
90CAMK2G0.31044512
91BMPR20.29334596
92ADRBK10.28941396
93MAP3K110.28310414
94LCK0.26937227
95ILK0.26900943
96MAP3K40.26853965
97MAPKAPK20.26788871
98PRKCQ0.26783527
99OXSR10.26513332
100PIM10.26230874

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.81959195
2Oxidative phosphorylation_Homo sapiens_hsa001903.60905297
3Parkinsons disease_Homo sapiens_hsa050122.93623728
4Asthma_Homo sapiens_hsa053102.45709071
5Protein export_Homo sapiens_hsa030602.39123754
6Antigen processing and presentation_Homo sapiens_hsa046122.30699050
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.23021363
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.21182228
9Primary immunodeficiency_Homo sapiens_hsa053402.21177619
10RNA polymerase_Homo sapiens_hsa030202.14940801
11Autoimmune thyroid disease_Homo sapiens_hsa053202.07631848
12Allograft rejection_Homo sapiens_hsa053302.01162813
13Sulfur metabolism_Homo sapiens_hsa009202.00253152
14Alzheimers disease_Homo sapiens_hsa050101.99201429
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.98442831
16Huntingtons disease_Homo sapiens_hsa050161.96368399
17Graft-versus-host disease_Homo sapiens_hsa053321.96034020
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92023728
19DNA replication_Homo sapiens_hsa030301.65545243
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.46598020
21Fatty acid elongation_Homo sapiens_hsa000621.42870270
22Nucleotide excision repair_Homo sapiens_hsa034201.42462312
23Rheumatoid arthritis_Homo sapiens_hsa053231.40566419
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.39212066
25Mismatch repair_Homo sapiens_hsa034301.38704413
26Pyrimidine metabolism_Homo sapiens_hsa002401.38214546
27Shigellosis_Homo sapiens_hsa051311.33454784
28Type I diabetes mellitus_Homo sapiens_hsa049401.31874547
29Spliceosome_Homo sapiens_hsa030401.26845958
30Viral myocarditis_Homo sapiens_hsa054161.24559792
31Cardiac muscle contraction_Homo sapiens_hsa042601.18099691
32Collecting duct acid secretion_Homo sapiens_hsa049661.16403069
33Homologous recombination_Homo sapiens_hsa034401.10075033
34Caffeine metabolism_Homo sapiens_hsa002321.09683016
35Hematopoietic cell lineage_Homo sapiens_hsa046401.04275957
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.03591627
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03321550
38Folate biosynthesis_Homo sapiens_hsa007901.01843538
39Purine metabolism_Homo sapiens_hsa002300.99162194
40RNA degradation_Homo sapiens_hsa030180.98971982
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97519108
42Phototransduction_Homo sapiens_hsa047440.92759545
43Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92243913
44Primary bile acid biosynthesis_Homo sapiens_hsa001200.91053891
45Sulfur relay system_Homo sapiens_hsa041220.87325621
46Propanoate metabolism_Homo sapiens_hsa006400.86604724
47Base excision repair_Homo sapiens_hsa034100.85548587
48RNA transport_Homo sapiens_hsa030130.83480677
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.82426469
50Tryptophan metabolism_Homo sapiens_hsa003800.81374776
51SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80887045
52Pyruvate metabolism_Homo sapiens_hsa006200.80183503
53Glutathione metabolism_Homo sapiens_hsa004800.79286907
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78835103
55Chemical carcinogenesis_Homo sapiens_hsa052040.78334940
56Ribosome_Homo sapiens_hsa030100.76851721
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.75314186
58Peroxisome_Homo sapiens_hsa041460.75097719
59Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74188565
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73011186
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72183743
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71759340
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71013865
64Systemic lupus erythematosus_Homo sapiens_hsa053220.61957356
65Basal transcription factors_Homo sapiens_hsa030220.61035860
66Vibrio cholerae infection_Homo sapiens_hsa051100.60194230
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.59583879
68Herpes simplex infection_Homo sapiens_hsa051680.59555612
69Salivary secretion_Homo sapiens_hsa049700.58866964
70Metabolic pathways_Homo sapiens_hsa011000.57256777
71Epstein-Barr virus infection_Homo sapiens_hsa051690.56163154
72Biosynthesis of amino acids_Homo sapiens_hsa012300.56074941
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54113144
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53820307
75Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51802319
76Butanoate metabolism_Homo sapiens_hsa006500.50415972
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.49703233
78Salmonella infection_Homo sapiens_hsa051320.49443899
79Regulation of autophagy_Homo sapiens_hsa041400.49319037
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48720422
81Carbon metabolism_Homo sapiens_hsa012000.48522777
82Fanconi anemia pathway_Homo sapiens_hsa034600.47795826
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47588464
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.47292709
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45063149
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43934028
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.43287887
88Nitrogen metabolism_Homo sapiens_hsa009100.40666810
89Non-homologous end-joining_Homo sapiens_hsa034500.39910764
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.39439620
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38330753
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.38259845
93Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37353407
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35452306
95Measles_Homo sapiens_hsa051620.32752447
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32156049
97Synaptic vesicle cycle_Homo sapiens_hsa047210.32001385
98Legionellosis_Homo sapiens_hsa051340.31495731
99Endocytosis_Homo sapiens_hsa041440.26876500
100Pertussis_Homo sapiens_hsa051330.26491323

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