CFAP97

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.87020410
2sperm motility (GO:0030317)9.11724744
3axonemal dynein complex assembly (GO:0070286)9.06187430
4male meiosis (GO:0007140)8.99904237
5acrosome assembly (GO:0001675)8.69002071
6sperm-egg recognition (GO:0035036)8.46017603
7multicellular organism reproduction (GO:0032504)8.44975171
8epithelial cilium movement (GO:0003351)8.18479315
9binding of sperm to zona pellucida (GO:0007339)8.09485218
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.99639946
11synaptonemal complex organization (GO:0070193)7.88020037
12plasma membrane fusion (GO:0045026)7.60034956
13cell-cell recognition (GO:0009988)7.52890069
14synaptonemal complex assembly (GO:0007130)7.52200938
15motile cilium assembly (GO:0044458)7.44547660
16spermatid development (GO:0007286)7.42171986
17acrosome reaction (GO:0007340)7.33116149
18cilium movement (GO:0003341)7.21830488
19DNA methylation involved in gamete generation (GO:0043046)7.20396526
20regulation of cilium movement (GO:0003352)6.85194396
21reproduction (GO:0000003)6.65771712
22male meiosis I (GO:0007141)6.39320920
23monoubiquitinated protein deubiquitination (GO:0035520)5.86902266
24single fertilization (GO:0007338)5.85574672
25cell wall macromolecule catabolic process (GO:0016998)5.80718481
26cell wall macromolecule metabolic process (GO:0044036)5.80718481
27chromosome organization involved in meiosis (GO:0070192)5.68774321
28meiotic nuclear division (GO:0007126)5.43222096
29meiotic cell cycle (GO:0051321)5.36686786
30fertilization (GO:0009566)5.34019426
31meiosis I (GO:0007127)5.18947065
32spermatogenesis (GO:0007283)4.93675877
33male gamete generation (GO:0048232)4.92344666
34seminiferous tubule development (GO:0072520)4.92340061
35sperm capacitation (GO:0048240)4.86350020
36gene silencing by RNA (GO:0031047)4.81381549
37microtubule depolymerization (GO:0007019)4.69676876
38protein localization to cilium (GO:0061512)4.68844881
39germ cell development (GO:0007281)4.61769635
40gamete generation (GO:0007276)4.61755309
41mitotic sister chromatid cohesion (GO:0007064)4.57881828
42microtubule severing (GO:0051013)4.52627016
43cellular process involved in reproduction in multicellular organism (GO:0022412)4.51845421
44negative regulation of inclusion body assembly (GO:0090084)4.43625301
45regulation of centriole replication (GO:0046599)4.38278636
46regulation of meiosis I (GO:0060631)4.38214743
47intraciliary transport (GO:0042073)4.31823779
48nuclear pore complex assembly (GO:0051292)4.26661565
49centriole replication (GO:0007099)4.25033460
50ventricular system development (GO:0021591)4.15998921
51ribonucleoprotein complex disassembly (GO:0032988)4.11432668
52DNA double-strand break processing (GO:0000729)3.97365136
53meiotic cell cycle process (GO:1903046)3.93564032
54regulation of microtubule-based movement (GO:0060632)3.86814892
55nuclear pore organization (GO:0006999)3.76325449
56genitalia morphogenesis (GO:0035112)3.75728783
57axoneme assembly (GO:0035082)3.71680489
58sister chromatid cohesion (GO:0007062)3.70359965
59cell recognition (GO:0008037)3.67205406
60multicellular organismal reproductive process (GO:0048609)3.62349435
61calcium ion-dependent exocytosis (GO:0017156)3.59753807
62centriole assembly (GO:0098534)3.58595570
63histone exchange (GO:0043486)3.57975479
64synapsis (GO:0007129)3.47251730
65regulation of inclusion body assembly (GO:0090083)3.47084180
66left/right pattern formation (GO:0060972)3.44472641
67lactate metabolic process (GO:0006089)3.39959286
68regulation of spindle checkpoint (GO:0090231)3.35619917
69DNA methylation (GO:0006306)3.34938072
70DNA alkylation (GO:0006305)3.34938072
71folic acid-containing compound biosynthetic process (GO:0009396)3.34097791
72organic cation transport (GO:0015695)3.32284362
73negative regulation of DNA repair (GO:0045738)3.23366501
74cilium organization (GO:0044782)3.23309560
75postreplication repair (GO:0006301)3.20954637
76spermatid nucleus differentiation (GO:0007289)3.19159201
77meiotic chromosome segregation (GO:0045132)3.18663024
78gene silencing (GO:0016458)3.16503599
79microtubule-based movement (GO:0007018)3.15935926
80regulation of DNA endoreduplication (GO:0032875)3.15537191
81non-recombinational repair (GO:0000726)3.14997986
82double-strand break repair via nonhomologous end joining (GO:0006303)3.14997986
83replication fork processing (GO:0031297)3.14700784
84pore complex assembly (GO:0046931)3.14652239
85protein polyglutamylation (GO:0018095)3.14642446
86DNA packaging (GO:0006323)3.14071364
87chromosome condensation (GO:0030261)3.12471967
88CENP-A containing nucleosome assembly (GO:0034080)3.12125496
89regulation of protein polyubiquitination (GO:1902914)3.11880415
90organelle disassembly (GO:1903008)3.10930323
91cilium assembly (GO:0042384)3.08971471
92ribosome assembly (GO:0042255)3.07848505
93chromatin remodeling at centromere (GO:0031055)3.04884849
94paraxial mesoderm development (GO:0048339)3.04808069
95positive regulation of developmental pigmentation (GO:0048087)2.97160469
96nucleus organization (GO:0006997)2.94620539
97chaperone-mediated protein complex assembly (GO:0051131)2.93477074
98neural tube formation (GO:0001841)2.93205487
99telomere maintenance via telomerase (GO:0007004)2.93077748
100somatic hypermutation of immunoglobulin genes (GO:0016446)2.92865694
101somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92865694
102negative regulation of organelle assembly (GO:1902116)2.88874549
103multicellular organismal development (GO:0007275)2.85913094
104DNA replication checkpoint (GO:0000076)2.85331255
105regulation of sister chromatid cohesion (GO:0007063)2.83508336
106somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80808894
107isotype switching (GO:0045190)2.80808894
108somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80808894
109regulation of sarcomere organization (GO:0060297)2.80491669
110cellular component assembly involved in morphogenesis (GO:0010927)2.80415363
111negative regulation of DNA-dependent DNA replication (GO:2000104)2.80339922
112somatic recombination of immunoglobulin gene segments (GO:0016447)2.80094198
113sister chromatid segregation (GO:0000819)2.79746066
114cilium morphogenesis (GO:0060271)2.79442615
115translesion synthesis (GO:0019985)2.78764610
116resolution of meiotic recombination intermediates (GO:0000712)2.78196089
117mitotic metaphase plate congression (GO:0007080)2.78153521
118metaphase plate congression (GO:0051310)2.77600869
119RNA-dependent DNA replication (GO:0006278)2.77516089
120regulation of translational fidelity (GO:0006450)2.75870745
121regulation of helicase activity (GO:0051095)2.75083109
122attachment of spindle microtubules to kinetochore (GO:0008608)2.74586709
123mitotic chromosome condensation (GO:0007076)2.74266585
124regulation of translational elongation (GO:0006448)2.73845835
125tRNA aminoacylation (GO:0043039)2.73746530
126amino acid activation (GO:0043038)2.73746530
127tRNA aminoacylation for protein translation (GO:0006418)2.73523471
128regulation of centrosome cycle (GO:0046605)2.71851978
129microtubule anchoring (GO:0034453)2.70421644
130regulation of histone H3-K9 methylation (GO:0051570)2.69558477
131protein refolding (GO:0042026)2.68379095
132establishment of integrated proviral latency (GO:0075713)2.67882539
133ether lipid metabolic process (GO:0046485)2.67665865
134kinetochore organization (GO:0051383)2.66548084
135negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.66423408
136nucleobase biosynthetic process (GO:0046112)2.65673364
137polyol catabolic process (GO:0046174)2.65651389
138positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.65649423
139positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.65649423
140positive regulation of mitotic sister chromatid separation (GO:1901970)2.65649423
141maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.64667757
142tetrahydrofolate metabolic process (GO:0046653)2.63316196
143regulation of centrosome duplication (GO:0010824)2.60993160
144DNA ligation (GO:0006266)2.60353349
145protein localization to kinetochore (GO:0034501)2.59811378
146purine nucleobase biosynthetic process (GO:0009113)2.59399240
147transcription elongation from RNA polymerase I promoter (GO:0006362)2.58393749
148glycerol ether metabolic process (GO:0006662)2.58107323
149regulation of pigment cell differentiation (GO:0050932)2.57888638
150prenylation (GO:0097354)2.57302531
151protein prenylation (GO:0018342)2.57302531
152negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.57018790
153interkinetic nuclear migration (GO:0022027)2.56922989
154DNA replication-dependent nucleosome assembly (GO:0006335)2.56490514
155DNA replication-dependent nucleosome organization (GO:0034723)2.56490514
156protein localization to chromosome, centromeric region (GO:0071459)2.55043731
157negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.54305036
158negative regulation of potassium ion transmembrane transport (GO:1901380)2.53938163
159somatic diversification of immunoglobulins (GO:0016445)2.53630961
160DNA-dependent DNA replication (GO:0006261)2.52234571
161DNA topological change (GO:0006265)2.51816805
162regulation of translational termination (GO:0006449)2.51591465
163somatic cell DNA recombination (GO:0016444)2.50679862
164somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.50679862
165mitotic nuclear envelope disassembly (GO:0007077)2.49423206
166DNA replication-independent nucleosome organization (GO:0034724)2.48726699
167DNA replication-independent nucleosome assembly (GO:0006336)2.48726699
168termination of RNA polymerase I transcription (GO:0006363)2.48524371
169DNA unwinding involved in DNA replication (GO:0006268)2.46762584
170protein K6-linked ubiquitination (GO:0085020)2.46744947
171mitotic G2/M transition checkpoint (GO:0044818)2.45878053
172negative regulation of DNA recombination (GO:0045910)2.45584588
173regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45192469
174biotin metabolic process (GO:0006768)2.44419735
175protein localization to chromosome (GO:0034502)2.43718670
176regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.43544720
177regulation of mitotic metaphase/anaphase transition (GO:0030071)2.43544720
178transcription from mitochondrial promoter (GO:0006390)2.41128103
179mitotic spindle checkpoint (GO:0071174)2.41089936
180maturation of 5.8S rRNA (GO:0000460)2.37310667
181cilium or flagellum-dependent cell motility (GO:0001539)13.3752374
182piRNA metabolic process (GO:0034587)10.8975465

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.58895481
2EZH2_22144423_ChIP-Seq_EOC_Human5.53668360
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.14535222
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.66317406
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.66200718
6ELK1_19687146_ChIP-ChIP_HELA_Human2.55459279
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.52044530
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.42245771
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38118190
10EWS_26573619_Chip-Seq_HEK293_Human2.33453369
11ZNF274_21170338_ChIP-Seq_K562_Hela2.24975864
12CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20282018
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.15735001
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.13193540
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12002386
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.07681422
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.07325632
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.98316166
19VDR_22108803_ChIP-Seq_LS180_Human1.88901421
20PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86564455
21FOXM1_23109430_ChIP-Seq_U2OS_Human1.84871619
22GBX2_23144817_ChIP-Seq_PC3_Human1.84168114
23MYC_18555785_ChIP-Seq_MESCs_Mouse1.71673727
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70497565
25P300_19829295_ChIP-Seq_ESCs_Human1.69695501
26FUS_26573619_Chip-Seq_HEK293_Human1.69571425
27PIAS1_25552417_ChIP-Seq_VCAP_Human1.66978980
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65169383
29EST1_17652178_ChIP-ChIP_JURKAT_Human1.64835230
30EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.63144756
31RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.62564400
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61076509
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60309867
34GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59017881
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.57938764
36GATA1_26923725_Chip-Seq_HPCs_Mouse1.53876548
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52700238
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51879509
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51704831
40ELK4_26923725_Chip-Seq_MESODERM_Mouse1.51657105
41YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50647486
42FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49622858
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47556046
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.47211734
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45272906
46CBP_20019798_ChIP-Seq_JUKART_Human1.45272906
47SALL1_21062744_ChIP-ChIP_HESCs_Human1.45140057
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.44425825
49PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.43559259
50TAF15_26573619_Chip-Seq_HEK293_Human1.43468582
51RNF2_27304074_Chip-Seq_NSC_Mouse1.42794312
52KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42109112
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.41077591
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.40357447
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39989980
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38204025
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37329060
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37329060
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36655794
60VDR_23849224_ChIP-Seq_CD4+_Human1.35688506
61E2F4_17652178_ChIP-ChIP_JURKAT_Human1.35037971
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.34871812
63STAT1_17558387_ChIP-Seq_HELA_Human1.33346208
64TAL1_26923725_Chip-Seq_HPCs_Mouse1.32068555
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31401960
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.28859146
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28841286
68AR_21572438_ChIP-Seq_LNCaP_Human1.28768691
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.28219082
70FLI1_21867929_ChIP-Seq_TH2_Mouse1.27646881
71KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26808335
72KDM2B_26808549_Chip-Seq_REH_Human1.26318873
73WDR5_24793694_ChIP-Seq_LNCAP_Human1.24358787
74CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24177322
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23985034
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.22927357
77GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.22787504
78CBX2_27304074_Chip-Seq_ESCs_Mouse1.21706883
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18514270
80MYC_18940864_ChIP-ChIP_HL60_Human1.18450067
81TCF4_23295773_ChIP-Seq_U87_Human1.18110977
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.18010299
83SMAD4_21799915_ChIP-Seq_A2780_Human1.16897593
84NOTCH1_21737748_ChIP-Seq_TLL_Human1.16488446
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16223550
86P53_22387025_ChIP-Seq_ESCs_Mouse1.16197685
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15358644
88BCAT_22108803_ChIP-Seq_LS180_Human1.14486373
89RUNX1_26923725_Chip-Seq_HPCs_Mouse1.13642129
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12750966
91CRX_20693478_ChIP-Seq_RETINA_Mouse1.12529829
92OCT4_18555785_Chip-Seq_ESCs_Mouse1.11898913
93CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11876043
94CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11393429
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11055244
96ER_23166858_ChIP-Seq_MCF-7_Human1.10492364
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09080280
98FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08010493
99FOXP3_21729870_ChIP-Seq_TREG_Human1.07861693
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07655506
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07551122
102ERG_20517297_ChIP-Seq_VCAP_Human1.07478504
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.06750664
104EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06593579
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06465620
106P300_18555785_Chip-Seq_ESCs_Mouse1.05416302
107CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05260289
108SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04997419
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04332661
110E2F7_22180533_ChIP-Seq_HELA_Human1.03775554
111ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03359298
112ETS1_20019798_ChIP-Seq_JURKAT_Human1.03113567
113JUN_21703547_ChIP-Seq_K562_Human1.02821638
114BRD4_25478319_ChIP-Seq_HGPS_Human1.01920740
115IGF1R_20145208_ChIP-Seq_DFB_Human1.01352898
116E2F1_18555785_Chip-Seq_ESCs_Mouse1.00667236
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.00373025
118RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99976384
119STAT3_23295773_ChIP-Seq_U87_Human0.99690385
120TP53_22573176_ChIP-Seq_HFKS_Human0.99643544
121CMYC_18555785_Chip-Seq_ESCs_Mouse0.99453442
122SOX9_26525672_Chip-Seq_HEART_Mouse0.99387390
123FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99318597
124SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.98591590
125AR_25329375_ChIP-Seq_VCAP_Human0.98356741
126NMYC_18555785_Chip-Seq_ESCs_Mouse0.98301470
127MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98280225
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98252453
129OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98226572
130MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.98159457
131SMAD3_21741376_ChIP-Seq_EPCs_Human0.97891532
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.97489525
133KLF4_18555785_Chip-Seq_ESCs_Mouse0.96063023
134GF1B_26923725_Chip-Seq_HPCs_Mouse0.94892006
135FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.94751347
136RUNX1_27457419_Chip-Seq_LIVER_Mouse0.91568382
137PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.91427072
138CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91357940
139SOX2_18555785_Chip-Seq_ESCs_Mouse0.91030691
140AR_21909140_ChIP-Seq_LNCAP_Human0.90815270
141CDX2_22108803_ChIP-Seq_LS180_Human0.90621789
142DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90022923
143TBL1_22424771_ChIP-Seq_293T_Human0.89910127
144REST_21632747_ChIP-Seq_MESCs_Mouse0.89690924
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89628220
146GF1_26923725_Chip-Seq_HPCs_Mouse0.87572846

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation7.23272333
2MP0001929_abnormal_gametogenesis4.91614346
3MP0003698_abnormal_male_reproductive4.90478219
4MP0002210_abnormal_sex_determination3.72886852
5MP0001145_abnormal_male_reproductive3.02528765
6MP0000653_abnormal_sex_gland2.84260531
7MP0002161_abnormal_fertility/fecundity2.80884154
8MP0008057_abnormal_DNA_replication2.76516755
9MP0002653_abnormal_ependyma_morphology2.69883723
10MP0003950_abnormal_plasma_membrane2.63864212
11MP0003890_abnormal_embryonic-extraembry2.57632574
12MP0010094_abnormal_chromosome_stability2.57417235
13MP0003787_abnormal_imprinting2.56498056
14MP0002160_abnormal_reproductive_system2.31623578
15MP0008058_abnormal_DNA_repair2.27215664
16MP0005171_absent_coat_pigmentation2.10166099
17MP0001529_abnormal_vocalization2.09999849
18MP0008007_abnormal_cellular_replicative2.05881514
19MP0005410_abnormal_fertilization10.6675578
20MP0003646_muscle_fatigue1.95396012
21MP0006054_spinal_hemorrhage1.77657222
22MP0002938_white_spotting1.74133183
23MP0003136_yellow_coat_color1.66745231
24MP0003941_abnormal_skin_development1.63963654
25MP0006072_abnormal_retinal_apoptosis1.57314889
26MP0005551_abnormal_eye_electrophysiolog1.56733079
27MP0003121_genomic_imprinting1.49839097
28MP0010352_gastrointestinal_tract_polyps1.46833803
29MP0004808_abnormal_hematopoietic_stem1.46748211
30MP0002234_abnormal_pharynx_morphology1.46437727
31MP0003077_abnormal_cell_cycle1.42523088
32MP0003693_abnormal_embryo_hatching1.39984158
33MP0001986_abnormal_taste_sensitivity1.39665609
34MP0002095_abnormal_skin_pigmentation1.38838410
35MP0003111_abnormal_nucleus_morphology1.37066715
36MP0009780_abnormal_chondrocyte_physiolo1.35741914
37MP0005389_reproductive_system_phenotype1.35717218
38MP0005623_abnormal_meninges_morphology1.35410347
39MP0004233_abnormal_muscle_weight1.29209125
40MP0005253_abnormal_eye_physiology1.23570572
41MP0003786_premature_aging1.22114262
42MP0002009_preneoplasia1.20006572
43MP0001286_abnormal_eye_development1.19410406
44MP0002166_altered_tumor_susceptibility1.17717590
45MP0001661_extended_life_span1.17673548
46MP0005645_abnormal_hypothalamus_physiol1.17037110
47MP0000647_abnormal_sebaceous_gland1.14843497
48MP0000372_irregular_coat_pigmentation1.14287286
49MP0004197_abnormal_fetal_growth/weight/1.13430959
50MP0002751_abnormal_autonomic_nervous1.12846432
51MP0000428_abnormal_craniofacial_morphol1.09556660
52MP0008995_early_reproductive_senescence1.09415302
53MP0001119_abnormal_female_reproductive1.08748039
54MP0002837_dystrophic_cardiac_calcinosis1.08700684
55MP0001299_abnormal_eye_distance/1.08576689
56MP0008789_abnormal_olfactory_epithelium1.07706073
57MP0001984_abnormal_olfaction1.06625571
58MP0000569_abnormal_digit_pigmentation1.05221464
59MP0005174_abnormal_tail_pigmentation1.04071151
60MP0005646_abnormal_pituitary_gland1.03897103
61MP0004957_abnormal_blastocyst_morpholog1.02855222
62MP0002006_tumorigenesis0.98952294
63MP0003567_abnormal_fetal_cardiomyocyte0.98678898
64MP0004272_abnormal_basement_membrane0.96576087
65MP0003755_abnormal_palate_morphology0.94834072
66MP0003699_abnormal_female_reproductive0.92591126
67MP0002282_abnormal_trachea_morphology0.91458017
68MP0010307_abnormal_tumor_latency0.90048265
69MP0005220_abnormal_exocrine_pancreas0.88447663
70MP0003252_abnormal_bile_duct0.88104410
71MP0002697_abnormal_eye_size0.87253235
72MP0002396_abnormal_hematopoietic_system0.87190426
73MP0003011_delayed_dark_adaptation0.86407335
74MP0000778_abnormal_nervous_system0.86206940
75MP0005647_abnormal_sex_gland0.85714852
76MP0005503_abnormal_tendon_morphology0.83950917
77MP0001730_embryonic_growth_arrest0.82968213
78MP0001849_ear_inflammation0.82941770
79MP0003123_paternal_imprinting0.81364219
80MP0001324_abnormal_eye_pigmentation0.80572122
81MP0009697_abnormal_copulation0.79346043
82MP0002102_abnormal_ear_morphology0.78360063
83MP0009703_decreased_birth_body0.76873900
84MP0003718_maternal_effect0.76447595
85MP0001188_hyperpigmentation0.76170537
86MP0003943_abnormal_hepatobiliary_system0.75321452
87MP0002084_abnormal_developmental_patter0.75081369
88MP0000432_abnormal_head_morphology0.74751365
89MP0008438_abnormal_cutaneous_collagen0.73479545
90MP0006292_abnormal_olfactory_placode0.72734956
91MP0002184_abnormal_innervation0.72414203
92MP0005499_abnormal_olfactory_system0.71770682
93MP0005394_taste/olfaction_phenotype0.71770682
94MP0002092_abnormal_eye_morphology0.71007544
95MP0002090_abnormal_vision0.70469798
96MP0003935_abnormal_craniofacial_develop0.70382238
97MP0003942_abnormal_urinary_system0.70204278
98MP0004134_abnormal_chest_morphology0.70046389
99MP0005397_hematopoietic_system_phenotyp0.67592216
100MP0001545_abnormal_hematopoietic_system0.67592216
101MP0009046_muscle_twitch0.67381762
102MP0002928_abnormal_bile_duct0.66707582
103MP0001697_abnormal_embryo_size0.66589891
104MP0005408_hypopigmentation0.64481779
105MP0005391_vision/eye_phenotype0.63825916
106MP0001765_abnormal_ion_homeostasis0.62515177
107MP0000631_abnormal_neuroendocrine_gland0.59491811
108MP0004036_abnormal_muscle_relaxation0.59304723
109MP0003937_abnormal_limbs/digits/tail_de0.57431082
110MP0005380_embryogenesis_phenotype0.57201573
111MP0001672_abnormal_embryogenesis/_devel0.57201573
112MP0010368_abnormal_lymphatic_system0.56906328
113MP0000313_abnormal_cell_death0.56347227
114MP0003385_abnormal_body_wall0.56029327
115MP0005195_abnormal_posterior_eye0.55788400
116MP0003115_abnormal_respiratory_system0.54995964
117MP0002233_abnormal_nose_morphology0.54863882
118MP0002085_abnormal_embryonic_tissue0.53241405
119MP0000350_abnormal_cell_proliferation0.51153970
120MP0002177_abnormal_outer_ear0.50890548
121MP0005187_abnormal_penis_morphology0.50165732
122MP0000358_abnormal_cell_content/0.48823320
123MP0003315_abnormal_perineum_morphology0.47714428
124MP0004084_abnormal_cardiac_muscle0.47498511
125MP0009250_abnormal_appendicular_skeleto0.47051460
126MP0005310_abnormal_salivary_gland0.45896065
127MP0004145_abnormal_muscle_electrophysio0.45837617
128MP0005379_endocrine/exocrine_gland_phen0.45632781
129MP0000015_abnormal_ear_pigmentation0.45402952
130MP0003984_embryonic_growth_retardation0.45214138
131MP0006138_congestive_heart_failure0.45209571
132MP0003861_abnormal_nervous_system0.45070506
133MP0000639_abnormal_adrenal_gland0.44640871
134MP0004264_abnormal_extraembryonic_tissu0.43997454
135MP0001919_abnormal_reproductive_system0.43312655
136MP0003122_maternal_imprinting0.43131706
137MP0002088_abnormal_embryonic_growth/wei0.42347498
138MP0002163_abnormal_gland_morphology0.41814606
139MP0005395_other_phenotype0.41063549
140MP0002114_abnormal_axial_skeleton0.41000640
141MP0000427_abnormal_hair_cycle0.40889470
142MP0002080_prenatal_lethality0.40776804
143MP0002877_abnormal_melanocyte_morpholog0.40507306
144MP0008932_abnormal_embryonic_tissue0.40384869
145MP0002109_abnormal_limb_morphology0.39895668
146MP0001293_anophthalmia0.39881710

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.11688416
2Abnormal respiratory motile cilium morphology (HP:0005938)7.29959941
3Abnormal respiratory epithelium morphology (HP:0012253)7.29959941
4Rhinitis (HP:0012384)6.90591637
5Abnormal ciliary motility (HP:0012262)6.50476472
6Chronic bronchitis (HP:0004469)6.40408688
7Infertility (HP:0000789)5.67218078
8Nasal polyposis (HP:0100582)5.01594831
9Nephronophthisis (HP:0000090)4.53646830
10Bronchiectasis (HP:0002110)4.17846029
11Abnormality of the nasal mucosa (HP:0000433)4.03103548
12Bronchitis (HP:0012387)3.86238706
13Abnormality of the lower motor neuron (HP:0002366)3.60553262
14Abnormality of the renal medulla (HP:0100957)3.56581980
15Chromsome breakage (HP:0040012)3.44005968
16Medial flaring of the eyebrow (HP:0010747)3.42155673
17Gonadotropin excess (HP:0000837)3.29575789
18Male infertility (HP:0003251)3.28505200
19Abnormality of midbrain morphology (HP:0002418)3.23654776
20Molar tooth sign on MRI (HP:0002419)3.23654776
21Colon cancer (HP:0003003)3.18253961
22Amyotrophic lateral sclerosis (HP:0007354)2.98492702
23Renal cortical cysts (HP:0000803)2.97138346
24Abnormal spermatogenesis (HP:0008669)2.93214639
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92723842
26Recurrent sinusitis (HP:0011108)2.82599466
27Upper motor neuron abnormality (HP:0002127)2.76864638
28Recurrent otitis media (HP:0000403)2.75459410
29Tubulointerstitial nephritis (HP:0001970)2.69241042
30Abnormality of chromosome stability (HP:0003220)2.67318054
31Abnormality of the anterior horn cell (HP:0006802)2.66472089
32Degeneration of anterior horn cells (HP:0002398)2.66472089
33Fibular hypoplasia (HP:0003038)2.53908440
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.50360166
35Congenital primary aphakia (HP:0007707)2.49968391
36Fair hair (HP:0002286)2.49595816
37Supernumerary spleens (HP:0009799)2.46386214
38Gait imbalance (HP:0002141)2.45023332
39Impulsivity (HP:0100710)2.43977611
40Postaxial foot polydactyly (HP:0001830)2.37138120
41Microglossia (HP:0000171)2.36293365
42Overlapping toe (HP:0001845)2.36032516
43Papillary thyroid carcinoma (HP:0002895)2.35303107
44Impaired proprioception (HP:0010831)2.32123443
45Tubulointerstitial abnormality (HP:0001969)2.30377196
46Azoospermia (HP:0000027)2.28085519
47Nephrogenic diabetes insipidus (HP:0009806)2.25103092
48Tubular atrophy (HP:0000092)2.24857580
49Renal dysplasia (HP:0000110)2.24775008
50Abnormality of the ileum (HP:0001549)2.22817999
51Pancreatic fibrosis (HP:0100732)2.21204196
52Meckel diverticulum (HP:0002245)2.17548290
53Recurrent bronchitis (HP:0002837)2.16792052
54Birth length less than 3rd percentile (HP:0003561)2.13973481
55Postaxial hand polydactyly (HP:0001162)2.12736725
56Termporal pattern (HP:0011008)2.09259997
57Insidious onset (HP:0003587)2.09259997
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.09105271
59Congenital hepatic fibrosis (HP:0002612)2.08646269
60Chronic hepatic failure (HP:0100626)2.06463035
61Thyroid-stimulating hormone excess (HP:0002925)2.04945724
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.04665972
63Congenital stationary night blindness (HP:0007642)2.04162411
64Abnormality of the renal cortex (HP:0011035)2.03244639
65Thyroid carcinoma (HP:0002890)2.02807303
66Medulloblastoma (HP:0002885)2.01893796
67Absent frontal sinuses (HP:0002688)2.01834236
68Poor coordination (HP:0002370)2.01288807
69Respiratory insufficiency due to defective ciliary clearance (HP:0200073)11.6002935
70Dynein arm defect of respiratory motile cilia (HP:0012255)10.3983508
71Absent/shortened dynein arms (HP:0200106)10.3983508
72Cystic liver disease (HP:0006706)1.99606258
73Median cleft lip (HP:0000161)1.96137693
7411 pairs of ribs (HP:0000878)1.95887484
75Short ribs (HP:0000773)1.92060006
76Bony spicule pigmentary retinopathy (HP:0007737)1.91029805
77Abnormal biliary tract morphology (HP:0012440)1.90995143
78Aplasia/Hypoplasia of the tibia (HP:0005772)1.90735479
79Biliary tract neoplasm (HP:0100574)1.88472687
80Cerebellar dysplasia (HP:0007033)1.88432518
81Hyperglycinemia (HP:0002154)1.87298958
82Cortical dysplasia (HP:0002539)1.85279425
83Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.84235289
84True hermaphroditism (HP:0010459)1.83901536
85Oculomotor apraxia (HP:0000657)1.83873841
86Abnormality of the preputium (HP:0100587)1.83065519
87Acanthocytosis (HP:0001927)1.82918165
88Tubulointerstitial fibrosis (HP:0005576)1.81670563
89Pancreatic cysts (HP:0001737)1.81426859
90Volvulus (HP:0002580)1.80288412
91Hypothermia (HP:0002045)1.79823891
92Type II lissencephaly (HP:0007260)1.79433249
93Neoplasm of the small intestine (HP:0100833)1.79263779
94Nephroblastoma (Wilms tumor) (HP:0002667)1.79032379
95Genital tract atresia (HP:0001827)1.78986832
96Cystic hygroma (HP:0000476)1.78430392
97Facial hemangioma (HP:0000329)1.77826512
98Heterotopia (HP:0002282)1.77638752
99Vaginal atresia (HP:0000148)1.75383219
100Generalized hypopigmentation of hair (HP:0011358)1.74860229
101Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.72278112
102Abnormality of the labia minora (HP:0012880)1.71672954
103Aplasia/Hypoplasia of the fibula (HP:0006492)1.71436338
104Embryonal renal neoplasm (HP:0011794)1.70722580
105Dyschromatopsia (HP:0007641)1.70382415
106Gaze-evoked nystagmus (HP:0000640)1.70214532
107Acute myeloid leukemia (HP:0004808)1.68816818
108Abnormal auditory evoked potentials (HP:0006958)1.68638598
109Neoplasm of the colon (HP:0100273)1.65793199
110Glioma (HP:0009733)1.65752414
111Degeneration of the lateral corticospinal tracts (HP:0002314)1.65580429
112Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.65580429
113Breast carcinoma (HP:0003002)1.64519090
114Facial cleft (HP:0002006)1.64176373
115Abnormal drinking behavior (HP:0030082)1.64083499
116Polydipsia (HP:0001959)1.64083499
117Neuroendocrine neoplasm (HP:0100634)1.64048059
118Aplasia/Hypoplasia of the lens (HP:0008063)1.63563446
119Stage 5 chronic kidney disease (HP:0003774)1.61934557
120Abnormality of ocular smooth pursuit (HP:0000617)1.61695045
121Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61240019
122Abnormality of alanine metabolism (HP:0010916)1.61240019
123Hyperalaninemia (HP:0003348)1.61240019
124Bifid tongue (HP:0010297)1.60833781
125Neoplasm of the peripheral nervous system (HP:0100007)1.60737578
126Short tibia (HP:0005736)1.59692411
127Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59480645
128Hyperventilation (HP:0002883)1.58721536
129Prominent nasal bridge (HP:0000426)1.58402987
130Myelodysplasia (HP:0002863)1.58045268
131Ectopic kidney (HP:0000086)1.58034024
132Sloping forehead (HP:0000340)1.57051496
133Attenuation of retinal blood vessels (HP:0007843)1.56212351
134Abnormality of macular pigmentation (HP:0008002)1.56008410
135Astigmatism (HP:0000483)1.55203381
136Truncal obesity (HP:0001956)1.55188306
137Abnormality of the carotid arteries (HP:0005344)1.55123132
138Broad foot (HP:0001769)1.54867669
139Small intestinal stenosis (HP:0012848)1.54788192
140Duodenal stenosis (HP:0100867)1.54788192
141Subaortic stenosis (HP:0001682)1.54593998
142Abnormality of the left ventricular outflow tract (HP:0011103)1.54593998
143Pancreatic islet-cell hyperplasia (HP:0004510)1.54222398
144Abnormality of the phalanges of the hallux (HP:0010057)1.54174399
145Conjunctival telangiectasia (HP:0000524)1.53648372
146Embryonal neoplasm (HP:0002898)1.53455556
147Pheochromocytoma (HP:0002666)1.53276803
148Abnormality of methionine metabolism (HP:0010901)1.53266563
149Postnatal microcephaly (HP:0005484)1.52950937
150Hyperinsulinemic hypoglycemia (HP:0000825)1.52275552
151Drooling (HP:0002307)1.51898942
152Decreased central vision (HP:0007663)1.51434209
153Abnormal lung lobation (HP:0002101)1.50951887
154Short foot (HP:0001773)1.50875576
155Absent epiphyses (HP:0010577)1.50810609
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.50810609
157Dandy-Walker malformation (HP:0001305)1.50757452
158Lissencephaly (HP:0001339)1.50576408
159Aplastic anemia (HP:0001915)1.50499454
160Abnormality of the intrinsic pathway (HP:0010989)1.50380041
161Exotropia (HP:0000577)1.49505194
162Small hand (HP:0200055)1.49405185
163Short middle phalanx of the 5th finger (HP:0004220)1.48861135
164Bile duct proliferation (HP:0001408)1.47504996
165Abnormal biliary tract physiology (HP:0012439)1.47504996
166Selective tooth agenesis (HP:0001592)1.46806744
167Abnormality of dentin (HP:0010299)1.45327736
168Vertebral arch anomaly (HP:0008438)1.45312276
169Freckling (HP:0001480)1.44298012
170Type II diabetes mellitus (HP:0005978)1.43994795
171Neoplasm of the oral cavity (HP:0100649)1.43825129
172Central scotoma (HP:0000603)1.43818775
173Atrophy/Degeneration involving motor neurons (HP:0007373)1.43199925
174Absent rod-and cone-mediated responses on ERG (HP:0007688)1.42380794

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.07387767
2PDK48.07387767
3PDK25.00843599
4PRKD33.56533708
5CDC73.26547885
6EIF2AK32.96817714
7EIF2AK12.79643395
8TESK12.65599124
9LATS12.60051110
10NEK22.43718521
11NEK12.19454170
12TAF12.09489311
13PTK2B2.04420571
14BCR2.02640781
15CCNB12.00458231
16ERBB31.95365644
17ICK1.93879535
18AKT31.93586615
19WNK41.90497565
20MST41.87957267
21TSSK61.86167057
22PNCK1.82090202
23STK31.77350392
24MKNK21.77120820
25SCYL21.75704856
26PLK41.65379978
27MKNK11.64060732
28CASK1.52850780
29MAP3K101.46319421
30PBK1.45294821
31TTK1.42870787
32STK381.36303635
33TRIM281.35499077
34STK391.30072082
35EIF2AK21.29747470
36PASK1.26142224
37STK38L1.23412473
38NEK91.22415485
39MUSK1.20024207
40BUB11.10251105
41BRSK21.05404325
42NUAK11.04976050
43CHEK21.04747554
44FLT31.03481644
45PLK21.02129759
46EEF2K0.96627042
47ATR0.96253289
48ZAK0.95618867
49MAP4K20.95103933
50TRPM70.94652292
51CDK120.92968259
52FGFR10.91537238
53WNK10.90015349
54PLK10.89064719
55CSNK1A1L0.88896150
56RPS6KB20.87400100
57FGFR30.84344317
58PDK10.80046651
59CHEK10.77940005
60ATM0.77867465
61BMPR20.77677622
62MAP2K70.77007680
63MAP3K40.76715306
64TAOK30.73439086
65WEE10.72891652
66FRK0.67239917
67CDK80.65914772
68MAP3K60.64133793
69MARK10.63190278
70DYRK30.62802725
71PRKCE0.62585417
72ERBB40.61758991
73RPS6KB10.61071803
74PINK10.60096391
75CLK10.58587730
76SGK20.58358385
77CDK90.58234310
78NLK0.58044365
79DYRK1B0.56043477
80TYRO30.55267910
81LATS20.55177308
82MAPK150.54955897
83CSNK1G10.54191800
84MAP2K60.54091217
85TNIK0.53827589
86CSNK1G20.53432357
87PLK30.53112523
88CDK30.52630142
89TEC0.52475932
90TGFBR10.50439998
91BRAF0.49783188
92PDGFRA0.49286204
93MAPK130.48094372
94PAK20.47956088
95RAF10.47919249
96CSNK1G30.47688984
97YES10.47166988
98PIK3CG0.46570376
99CSNK1E0.46271231
100MET0.45783898
101PRKAA10.44931658
102BRD40.44011740
103BMPR1B0.43894269
104VRK10.40816240
105CSNK2A20.39229103
106BRSK10.38402283
107MST1R0.37151120
108NTRK30.36669880
109PAK30.36607854
110MAPKAPK30.36405869
111MAP3K120.36299453
112FER0.34687876
113CDK10.33152837
114AURKB0.32779106
115CDK20.29788802
116NEK60.27397450
117TAOK10.24737760
118LMTK20.23658329
119WNK30.23482853
120SGK30.22599791
121CAMK1G0.22217766
122NTRK20.21100105
123MELK0.21030333
124PRKD20.19637761
125RPS6KA40.19315230
126MAPK100.19190209
127GSK3B0.19177062
128CDK60.17249652
129RIPK40.16953153
130MTOR0.16875181
131SGK4940.16869587
132SGK2230.16869587
133GRK10.16738014
134PRKDC0.16630628
135MAPK140.15569938
136IRAK10.14195366
137RPS6KA30.13201139
138CSNK2A10.13175826
139CDK40.13046835
140CSNK1D0.12699116
141PRKAA20.12693581
142PDGFRB0.11535274
143PRKCG0.10174510
144MARK20.09955483
145ACVR1B0.09618137
146SRPK10.09530066
147PDPK10.09049929
148CAMKK10.08335808
149STK100.08213967
150MAPKAPK50.08204171
151MAP2K40.07124466
152MAPK80.06599550

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.04427844
2Basal transcription factors_Homo sapiens_hsa030223.56575949
3Phototransduction_Homo sapiens_hsa047443.43195940
4Fanconi anemia pathway_Homo sapiens_hsa034603.23837291
5Pyruvate metabolism_Homo sapiens_hsa006203.19127831
6Protein export_Homo sapiens_hsa030603.07930348
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00287410
8One carbon pool by folate_Homo sapiens_hsa006702.99239336
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.68783978
10Oocyte meiosis_Homo sapiens_hsa041142.66426689
11Glucagon signaling pathway_Homo sapiens_hsa049222.65319406
12Dorso-ventral axis formation_Homo sapiens_hsa043202.51057866
13Cell cycle_Homo sapiens_hsa041102.36824095
14Selenocompound metabolism_Homo sapiens_hsa004502.17481282
15mRNA surveillance pathway_Homo sapiens_hsa030152.13525805
16RNA degradation_Homo sapiens_hsa030182.11808534
17RNA transport_Homo sapiens_hsa030132.09235796
18Steroid biosynthesis_Homo sapiens_hsa001002.00608488
19Amphetamine addiction_Homo sapiens_hsa050311.96126296
20Propanoate metabolism_Homo sapiens_hsa006401.91317376
21Homologous recombination_Homo sapiens_hsa034401.75673400
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.72285670
23Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.70032069
24DNA replication_Homo sapiens_hsa030301.68200417
25Long-term potentiation_Homo sapiens_hsa047201.65767017
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.63782240
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63287527
28RNA polymerase_Homo sapiens_hsa030201.61364178
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61344407
30Mismatch repair_Homo sapiens_hsa034301.56080138
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53695230
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.52123480
33Huntingtons disease_Homo sapiens_hsa050161.42337796
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38282765
35Renin secretion_Homo sapiens_hsa049241.38273068
36Butanoate metabolism_Homo sapiens_hsa006501.37992643
37Linoleic acid metabolism_Homo sapiens_hsa005911.36962171
38Non-homologous end-joining_Homo sapiens_hsa034501.36880301
39Purine metabolism_Homo sapiens_hsa002301.34598486
40Pentose phosphate pathway_Homo sapiens_hsa000301.32946873
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.32806097
42Lysine degradation_Homo sapiens_hsa003101.32307451
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.31494016
44Circadian rhythm_Homo sapiens_hsa047101.19010192
45Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15936444
46Fatty acid biosynthesis_Homo sapiens_hsa000611.09777980
47Nucleotide excision repair_Homo sapiens_hsa034201.08835113
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08471464
49TGF-beta signaling pathway_Homo sapiens_hsa043501.03665676
50Olfactory transduction_Homo sapiens_hsa047401.02894401
51Taste transduction_Homo sapiens_hsa047420.97036833
52Hippo signaling pathway_Homo sapiens_hsa043900.95651397
53Spliceosome_Homo sapiens_hsa030400.94089305
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93884116
55Base excision repair_Homo sapiens_hsa034100.93509074
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92337428
57Colorectal cancer_Homo sapiens_hsa052100.91772125
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90186458
59Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89771528
60Insulin secretion_Homo sapiens_hsa049110.89338290
61Fatty acid metabolism_Homo sapiens_hsa012120.86562031
62Pyrimidine metabolism_Homo sapiens_hsa002400.86359904
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86275152
64MicroRNAs in cancer_Homo sapiens_hsa052060.85415803
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85367866
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85084444
67Adherens junction_Homo sapiens_hsa045200.84672899
68Dopaminergic synapse_Homo sapiens_hsa047280.82598234
69N-Glycan biosynthesis_Homo sapiens_hsa005100.80713049
70Circadian entrainment_Homo sapiens_hsa047130.79398139
71p53 signaling pathway_Homo sapiens_hsa041150.77776300
72Antigen processing and presentation_Homo sapiens_hsa046120.76403693
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75892933
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74851612
75Glycerolipid metabolism_Homo sapiens_hsa005610.74792110
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74306836
77Glutamatergic synapse_Homo sapiens_hsa047240.69268986
78Peroxisome_Homo sapiens_hsa041460.68851129
79Calcium signaling pathway_Homo sapiens_hsa040200.68707171
80Estrogen signaling pathway_Homo sapiens_hsa049150.68434204
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.66355095
82Basal cell carcinoma_Homo sapiens_hsa052170.63086518
83Cardiac muscle contraction_Homo sapiens_hsa042600.61914803
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61091597
85Glycerophospholipid metabolism_Homo sapiens_hsa005640.60734610
86Melanoma_Homo sapiens_hsa052180.58775787
87Ovarian steroidogenesis_Homo sapiens_hsa049130.58114850
88Glycosaminoglycan degradation_Homo sapiens_hsa005310.56225416
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55711085
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.55232316
91Inositol phosphate metabolism_Homo sapiens_hsa005620.55138087
92Wnt signaling pathway_Homo sapiens_hsa043100.54907338
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.54659367
94Synaptic vesicle cycle_Homo sapiens_hsa047210.54115205
95beta-Alanine metabolism_Homo sapiens_hsa004100.52442151
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51177697
97Alcoholism_Homo sapiens_hsa050340.49534068
98Type II diabetes mellitus_Homo sapiens_hsa049300.49211153
99Pancreatic cancer_Homo sapiens_hsa052120.48924742
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48674500
101Oxytocin signaling pathway_Homo sapiens_hsa049210.48244598
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47810881
103Thyroid cancer_Homo sapiens_hsa052160.47450243
104HTLV-I infection_Homo sapiens_hsa051660.47364335
105Fatty acid elongation_Homo sapiens_hsa000620.46936911
106Small cell lung cancer_Homo sapiens_hsa052220.46916618
107cAMP signaling pathway_Homo sapiens_hsa040240.46525760
108VEGF signaling pathway_Homo sapiens_hsa043700.46485815
109Nicotine addiction_Homo sapiens_hsa050330.46306826
110ABC transporters_Homo sapiens_hsa020100.46028828
111Morphine addiction_Homo sapiens_hsa050320.45424138
112ECM-receptor interaction_Homo sapiens_hsa045120.45252264
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44729060
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44177417
115Fatty acid degradation_Homo sapiens_hsa000710.43750210
116Fructose and mannose metabolism_Homo sapiens_hsa000510.43418789
117Ribosome_Homo sapiens_hsa030100.42791814
118Cocaine addiction_Homo sapiens_hsa050300.41544399
119Prostate cancer_Homo sapiens_hsa052150.41340744
120Epstein-Barr virus infection_Homo sapiens_hsa051690.41082758
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40969024
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40561752
123Thyroid hormone synthesis_Homo sapiens_hsa049180.40199344
124Metabolic pathways_Homo sapiens_hsa011000.39594319
125Viral carcinogenesis_Homo sapiens_hsa052030.39541141
126Systemic lupus erythematosus_Homo sapiens_hsa053220.38814041
127Carbon metabolism_Homo sapiens_hsa012000.38625081
128Biosynthesis of amino acids_Homo sapiens_hsa012300.38315153
129mTOR signaling pathway_Homo sapiens_hsa041500.37678308
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37455959
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.37234987
132Proteasome_Homo sapiens_hsa030500.36042333
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35548746
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34943888
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.34692488
136Folate biosynthesis_Homo sapiens_hsa007900.33616783
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33608150
138PI3K-Akt signaling pathway_Homo sapiens_hsa041510.32411590
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32065321
140Ether lipid metabolism_Homo sapiens_hsa005650.31872589
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30918396
142Tryptophan metabolism_Homo sapiens_hsa003800.30257118
143Hedgehog signaling pathway_Homo sapiens_hsa043400.29487003
144AMPK signaling pathway_Homo sapiens_hsa041520.28568669
145Pathways in cancer_Homo sapiens_hsa052000.28368568
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.27511528
147Herpes simplex infection_Homo sapiens_hsa051680.27413110
148Sphingolipid metabolism_Homo sapiens_hsa006000.26318608
149Nitrogen metabolism_Homo sapiens_hsa009100.26162854
150MAPK signaling pathway_Homo sapiens_hsa040100.26010754
151Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.25307524
152Long-term depression_Homo sapiens_hsa047300.24097621
153Retinol metabolism_Homo sapiens_hsa008300.23981578

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