CFAP53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene belongs to the CFAP53 family. It was found to be differentially expressed by the ciliated cells of frog epidermis and in skin fibroblasts from human. Mutations in this gene are associated with visceral heterotaxy-6, which implicates this gene in determination of left-right asymmetric patterning. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement (GO:0003351)9.29252194
2fusion of sperm to egg plasma membrane (GO:0007342)8.19190433
3motile cilium assembly (GO:0044458)8.11882520
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.03579548
5multicellular organism reproduction (GO:0032504)7.99454577
6sperm motility (GO:0030317)7.73939283
7sperm-egg recognition (GO:0035036)7.18971105
8piRNA metabolic process (GO:0034587)6.69009406
9acrosome assembly (GO:0001675)6.65554657
10acrosome reaction (GO:0007340)6.62233412
11cell-cell recognition (GO:0009988)6.49607437
12reproduction (GO:0000003)6.42941563
13axoneme assembly (GO:0035082)6.28128787
14cell wall macromolecule metabolic process (GO:0044036)6.21962252
15cell wall macromolecule catabolic process (GO:0016998)6.21962252
16binding of sperm to zona pellucida (GO:0007339)6.19867211
17ventricular system development (GO:0021591)6.04584253
18plasma membrane fusion (GO:0045026)5.99905207
19male meiosis (GO:0007140)5.85766056
20spermatid development (GO:0007286)5.71124170
21single fertilization (GO:0007338)5.61749216
22regulation of cilium movement (GO:0003352)5.25563991
23primary alcohol catabolic process (GO:0034310)5.15628374
24meiotic cell cycle (GO:0051321)4.95784816
25regulation of microtubule-based movement (GO:0060632)4.86882781
26centriole assembly (GO:0098534)4.86521328
27vitamin transmembrane transport (GO:0035461)4.85364108
28left/right axis specification (GO:0070986)4.78627989
29synaptonemal complex organization (GO:0070193)4.74537962
30diterpenoid biosynthetic process (GO:0016102)4.70890884
31fertilization (GO:0009566)4.64212886
32male meiosis I (GO:0007141)4.55291305
33DNA methylation involved in gamete generation (GO:0043046)4.55099219
34ethanol metabolic process (GO:0006067)4.52190165
35GTP biosynthetic process (GO:0006183)4.51408073
36synaptonemal complex assembly (GO:0007130)4.46429976
37nucleoside diphosphate phosphorylation (GO:0006165)4.41591282
38spermatogenesis (GO:0007283)4.02371847
39male gamete generation (GO:0048232)4.01655384
40one-carbon compound transport (GO:0019755)3.99598316
41cilium organization (GO:0044782)3.94815469
42UTP biosynthetic process (GO:0006228)3.92638645
43centriole replication (GO:0007099)3.92443218
44microtubule polymerization or depolymerization (GO:0031109)3.86481286
45chromosome organization involved in meiosis (GO:0070192)3.82890690
46sperm capacitation (GO:0048240)3.78240189
47gamete generation (GO:0007276)3.77647548
48pyrimidine-containing compound transmembrane transport (GO:0072531)3.76590948
49lung epithelium development (GO:0060428)3.76354354
50response to xenobiotic stimulus (GO:0009410)3.75988390
51cilium assembly (GO:0042384)3.72768003
52intraciliary transport (GO:0042073)3.72645247
53superoxide anion generation (GO:0042554)3.71613748
54determination of left/right symmetry (GO:0007368)3.70265835
55negative regulation of T cell differentiation in thymus (GO:0033085)3.68719697
56glomerular epithelial cell development (GO:0072310)3.65431874
57meiosis I (GO:0007127)3.61245608
58lateral ventricle development (GO:0021670)3.58578620
59microtubule depolymerization (GO:0007019)3.56808382
60determination of bilateral symmetry (GO:0009855)3.55208691
61regulation of interleukin-5 production (GO:0032674)3.51862022
62smoothened signaling pathway (GO:0007224)3.51572201
63specification of symmetry (GO:0009799)3.48191271
64establishment of apical/basal cell polarity (GO:0035089)3.47384337
65ethanol oxidation (GO:0006069)3.45228173
66meiotic nuclear division (GO:0007126)3.44974795
67UTP metabolic process (GO:0046051)3.44302433
68terpenoid biosynthetic process (GO:0016114)3.37297207
69microtubule severing (GO:0051013)3.36859060
70meiotic chromosome segregation (GO:0045132)3.31698999
71establishment of monopolar cell polarity (GO:0061162)3.30282504
72establishment or maintenance of monopolar cell polarity (GO:0061339)3.30282504
73establishment of tissue polarity (GO:0007164)3.29516002
74establishment of planar polarity (GO:0001736)3.29516002
75germ cell development (GO:0007281)3.26982271
76tolerance induction (GO:0002507)3.25083354
77cellular process involved in reproduction in multicellular organism (GO:0022412)3.23879714
78retinoic acid metabolic process (GO:0042573)3.22988503
79cellular component assembly involved in morphogenesis (GO:0010927)3.19569701
80organic cation transport (GO:0015695)3.18425780
81negative regulation of immunoglobulin mediated immune response (GO:0002890)3.18015766
82negative regulation of B cell mediated immunity (GO:0002713)3.18015766
83cytoplasmic microtubule organization (GO:0031122)3.12561019
84cilium morphogenesis (GO:0060271)3.09486118
85negative regulation of humoral immune response (GO:0002921)3.07453858
86detection of other organism (GO:0098543)3.07046646
87monoubiquitinated protein deubiquitination (GO:0035520)3.03136019
88natural killer cell mediated immunity (GO:0002228)3.02206461
89natural killer cell mediated cytotoxicity (GO:0042267)3.02206461
90synapsis (GO:0007129)3.01254547
91regulation of interleukin-13 production (GO:0032656)2.99418078
92nonmotile primary cilium assembly (GO:0035058)2.98187261
93multicellular organismal reproductive process (GO:0048609)2.94969379
94guanosine-containing compound biosynthetic process (GO:1901070)2.93330406
95retinal rod cell development (GO:0046548)2.92925075
96glutathione derivative biosynthetic process (GO:1901687)2.92765402
97glutathione derivative metabolic process (GO:1901685)2.92765402
98protein localization to cilium (GO:0061512)2.91941878
99microtubule-based process (GO:0007017)2.91764723
100detection of bacterium (GO:0016045)2.90579030
101retinol metabolic process (GO:0042572)2.82062321
102CTP biosynthetic process (GO:0006241)2.81972187
103CTP metabolic process (GO:0046036)2.81972187
104positive regulation of smoothened signaling pathway (GO:0045880)2.81654852
105meiotic cell cycle process (GO:1903046)2.81445988
106cellular response to gamma radiation (GO:0071480)2.80900824
107regulation of dendritic cell antigen processing and presentation (GO:0002604)2.77316717
108organelle assembly (GO:0070925)2.75394476
109exogenous drug catabolic process (GO:0042738)2.74355658
110negative regulation of inclusion body assembly (GO:0090084)2.74135902
111asymmetric protein localization (GO:0008105)2.70711861
112microtubule-based movement (GO:0007018)2.69256873
113seminiferous tubule development (GO:0072520)2.69223584
114phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.69044727
115apical protein localization (GO:0045176)2.67811757
116protein polyglutamylation (GO:0018095)2.67091066
117cell recognition (GO:0008037)2.66463464
118microtubule bundle formation (GO:0001578)2.66345027
119pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65265648
120spermatid nucleus differentiation (GO:0007289)2.64849457
121primary alcohol metabolic process (GO:0034308)2.62281931
122reciprocal DNA recombination (GO:0035825)2.61988264
123reciprocal meiotic recombination (GO:0007131)2.61988264
124regulation of inclusion body assembly (GO:0090083)2.61058409
125regulation of spindle checkpoint (GO:0090231)2.61046982
126regulation of germinal center formation (GO:0002634)2.58148427
127negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.56987923
128regulation of RIG-I signaling pathway (GO:0039535)2.54173550
129interferon-gamma secretion (GO:0072643)2.53280229
130positive regulation of cellular amide metabolic process (GO:0034250)2.52918587
131lateral sprouting from an epithelium (GO:0060601)2.52594472
132pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.50170332
133spinal cord motor neuron differentiation (GO:0021522)2.49294173
134photoreceptor cell maintenance (GO:0045494)2.49057919
135intra-S DNA damage checkpoint (GO:0031573)2.48984505
136regulation of mononuclear cell migration (GO:0071675)2.48778367
137nucleotide phosphorylation (GO:0046939)2.48060052
138regulation of autophagic vacuole assembly (GO:2000785)2.44968213
139limb development (GO:0060173)2.44770186
140appendage development (GO:0048736)2.44770186
141regulation of centriole replication (GO:0046599)2.44272507
142left/right pattern formation (GO:0060972)2.42943982
143single strand break repair (GO:0000012)2.42554187
144cell projection assembly (GO:0030031)2.42549921
145heart looping (GO:0001947)2.41698937
146histone exchange (GO:0043486)2.40538424
147phosphatidylethanolamine biosynthetic process (GO:0006646)2.39460697
148nucleoside diphosphate metabolic process (GO:0009132)2.39442391
149O-glycan processing (GO:0016266)2.39233212
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.39144285
151response to peptidoglycan (GO:0032494)2.38001879
152regulation of collateral sprouting (GO:0048670)2.37426161
153positive regulation of tolerance induction (GO:0002645)2.37381839
154protein refolding (GO:0042026)2.37042092
155regulation of activation of Janus kinase activity (GO:0010533)2.36565721
156antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.36275451
157positive regulation of antigen processing and presentation (GO:0002579)2.36037308
158establishment of nucleus localization (GO:0040023)2.35780207
159phosphatidylcholine biosynthetic process (GO:0006656)2.34542750
160regulation of smoothened signaling pathway (GO:0008589)2.33959748
161embryonic heart tube morphogenesis (GO:0003143)2.31464832
162neurotransmitter catabolic process (GO:0042135)2.29298334
163aldehyde catabolic process (GO:0046185)2.28074431
164cilium or flagellum-dependent cell motility (GO:0001539)12.3557493
165axonemal dynein complex assembly (GO:0070286)11.3332148
166cilium movement (GO:0003341)10.1904243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.28479681
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.02785742
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.89591338
4PCGF2_27294783_Chip-Seq_ESCs_Mouse3.48647250
5FLI1_27457419_Chip-Seq_LIVER_Mouse3.41839531
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.29815262
7PCGF2_27294783_Chip-Seq_NPCs_Mouse2.97454771
8SUZ12_27294783_Chip-Seq_NPCs_Mouse2.85934303
9NFE2_27457419_Chip-Seq_LIVER_Mouse2.80250994
10DROSHA_22980978_ChIP-Seq_HELA_Human2.78079955
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74146908
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.61300858
13KAP1_22055183_ChIP-Seq_ESCs_Mouse2.54826930
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.23099537
15EZH2_27294783_Chip-Seq_NPCs_Mouse2.19612922
16FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.15330466
17TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse2.03679618
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02573222
19PIAS1_25552417_ChIP-Seq_VCAP_Human2.01114745
20STAT3_18555785_Chip-Seq_ESCs_Mouse1.98557239
21BP1_19119308_ChIP-ChIP_Hs578T_Human1.97758587
22EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.95019433
23PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.94124780
24EZH2_22144423_ChIP-Seq_EOC_Human1.93437220
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93327535
26P53_22387025_ChIP-Seq_ESCs_Mouse1.91398117
27OCT4_18555785_Chip-Seq_ESCs_Mouse1.87794007
28SUZ12_18555785_Chip-Seq_ESCs_Mouse1.87273407
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.85108544
30ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84732858
31CRX_20693478_ChIP-Seq_RETINA_Mouse1.82148252
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81574411
33STAT1_17558387_ChIP-Seq_HELA_Human1.80725911
34TOP2B_26459242_ChIP-Seq_MCF-7_Human1.77628532
35EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.77508787
36ZFX_18555785_Chip-Seq_ESCs_Mouse1.77090261
37OCT4_21477851_ChIP-Seq_ESCs_Mouse1.76709724
38P300_18555785_Chip-Seq_ESCs_Mouse1.76589572
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.75586854
40NMYC_18555785_Chip-Seq_ESCs_Mouse1.74132109
41CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.73144424
42ESRRB_18555785_Chip-Seq_ESCs_Mouse1.73130581
43E2F7_22180533_ChIP-Seq_HELA_Human1.72989829
44AHR_22903824_ChIP-Seq_MCF-7_Human1.72784692
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.72138926
46E2F1_18555785_Chip-Seq_ESCs_Mouse1.71275346
47CMYC_18555785_Chip-Seq_ESCs_Mouse1.71251819
48KLF4_18555785_Chip-Seq_ESCs_Mouse1.70700255
49SOX2_18555785_Chip-Seq_ESCs_Mouse1.67800179
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.67318425
51RUNX1_27457419_Chip-Seq_LIVER_Mouse1.66939437
52IRF8_22096565_ChIP-ChIP_GC-B_Human1.66451767
53PU1_27457419_Chip-Seq_LIVER_Mouse1.62091711
54ARNT_22903824_ChIP-Seq_MCF-7_Human1.61793150
55CTCF_18555785_Chip-Seq_ESCs_Mouse1.60370507
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57405174
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57392684
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56567440
59IRF8_27001747_Chip-Seq_BMDM_Mouse1.56421234
60Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55523301
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55226579
62SMAD4_21799915_ChIP-Seq_A2780_Human1.55069035
63GATA1_26923725_Chip-Seq_HPCs_Mouse1.53739773
64SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.53572169
65SMAD1_18555785_Chip-Seq_ESCs_Mouse1.52311242
66TAL1_26923725_Chip-Seq_HPCs_Mouse1.49594205
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48669449
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42341270
69FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42317417
70KDM2B_26808549_Chip-Seq_REH_Human1.41887597
71ETV1_20927104_ChIP-Seq_GIST48_Human1.41407151
72TP53_18474530_ChIP-ChIP_U2OS_Human1.38546877
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.37648773
74FUS_26573619_Chip-Seq_HEK293_Human1.37435146
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.37386553
76ZNF274_21170338_ChIP-Seq_K562_Hela1.36162955
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34992635
78AR_21572438_ChIP-Seq_LNCaP_Human1.34732909
79RNF2_27304074_Chip-Seq_NSC_Mouse1.34622031
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.34306897
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32186538
82POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30402797
83TP63_23658742_ChIP-Seq_EP156T_Human1.29880395
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29635627
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.29448485
86BCAT_22108803_ChIP-Seq_LS180_Human1.28932113
87WDR5_24793694_ChIP-Seq_LNCAP_Human1.28336164
88TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27391775
89PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27023366
90TAF15_26573619_Chip-Seq_HEK293_Human1.26646759
91STAT3_23295773_ChIP-Seq_U87_Human1.26427219
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25885365
93ESR1_20079471_ChIP-ChIP_T-47D_Human1.25794669
94HNFA_21074721_ChIP-Seq_CACO-2_Human1.25372663
95EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24797560
96CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.24372231
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.23746655
98TCF4_22108803_ChIP-Seq_LS180_Human1.22863075
99SMC4_20622854_ChIP-Seq_HELA_Human1.22019718
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21513089
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.21513089
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19476072
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.19212043
104STAT1_20625510_ChIP-Seq_HELA_Human1.18447147
105FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.18253803
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17967157
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16915187
108GATA3_21867929_ChIP-Seq_TH1_Mouse1.16687590
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16333582
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.14102345
111RBPJ_21746931_ChIP-Seq_IB4_Human1.13806325
112PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13216053
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.13054302
114CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12653388
115ER_23166858_ChIP-Seq_MCF-7_Human1.12160500
116ELK4_26923725_Chip-Seq_MESODERM_Mouse1.11911188
117HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11565809
118SMRT_27268052_Chip-Seq_Bcells_Human1.11026277
119AR_25329375_ChIP-Seq_VCAP_Human1.10787695
120REST_21632747_ChIP-Seq_MESCs_Mouse1.10094129
121GF1_26923725_Chip-Seq_HPCs_Mouse1.09839288
122KLF5_25053715_ChIP-Seq_YYC3_Human1.09507534
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09257921
124RUNX2_22187159_ChIP-Seq_PCA_Human1.08287575
125PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08135127
126PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07374121
127VDR_22108803_ChIP-Seq_LS180_Human1.07175676
128RUNX1_27514584_Chip-Seq_MCF-7_Human1.07131897
129P300_19829295_ChIP-Seq_ESCs_Human1.06805923
130TP63_22573176_ChIP-Seq_HFKS_Human1.06639962
131NFYA_21822215_ChIP-Seq_K562_Human1.05915271
132GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05606223
133MYC_19829295_ChIP-Seq_ESCs_Human1.05184659
134TCF4_23295773_ChIP-Seq_U87_Human1.05046734
135CBP_20019798_ChIP-Seq_JUKART_Human1.04632280
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04632280
137CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04517482
138SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04393983
139FOXA1_25552417_ChIP-Seq_VCAP_Human1.03676569
140SUZ12_27294783_Chip-Seq_ESCs_Mouse1.03455490
141ERG_20517297_ChIP-Seq_VCAP_Human1.03438139
142CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03227738
143SOX2_22085726_ChIP-Seq_NPCs_Mouse1.02591608
144CTCF_27219007_Chip-Seq_Bcells_Human1.02186292
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.01321139
146CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00088352
147YY1_22570637_ChIP-Seq_MALME-3M_Human0.99994300
148EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.99299129
149AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99091203
150NFYB_21822215_ChIP-Seq_K562_Human0.97978776
151GATA6_21074721_ChIP-Seq_CACO-2_Human0.97360698
152SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97356097
153AR_20517297_ChIP-Seq_VCAP_Human0.97189081
154GBX2_23144817_ChIP-Seq_PC3_Human0.96115122
155STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95897605
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95458333
157FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95064903
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94707946
159TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94172250
160GATA3_21867929_ChIP-Seq_CD8_Mouse0.94086856
161RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93042971
162CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92943109
163NCOR_22424771_ChIP-Seq_293T_Human0.92704095
164SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.92013506
165CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91610729
166MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89924832
167LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88876812
168LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88794287
169RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88269119
170CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87413405
171TBL1_22424771_ChIP-Seq_293T_Human0.86124385
172FOXA1_25329375_ChIP-Seq_VCAP_Human0.85880725
173FOXA1_27270436_Chip-Seq_PROSTATE_Human0.85880725
174PHF8_20622853_ChIP-Seq_HELA_Human0.85693688
175CDX2_22108803_ChIP-Seq_LS180_Human0.84786288
176GF1B_26923725_Chip-Seq_HPCs_Mouse0.84445978

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.60835403
2MP0008875_abnormal_xenobiotic_pharmacok4.76059079
3MP0001984_abnormal_olfaction3.62766681
4MP0003698_abnormal_male_reproductive3.54818388
5MP0001929_abnormal_gametogenesis3.52572983
6MP0008789_abnormal_olfactory_epithelium3.28035403
7MP0004043_abnormal_pH_regulation3.10947343
8MP0002653_abnormal_ependyma_morphology3.07468592
9MP0004133_heterotaxia2.92576853
10MP0008057_abnormal_DNA_replication2.89135749
11MP0008877_abnormal_DNA_methylation2.85651325
12MP0001835_abnormal_antigen_presentation2.72002464
13MP0002210_abnormal_sex_determination2.67804163
14MP0003136_yellow_coat_color2.67245727
15MP0005377_hearing/vestibular/ear_phenot2.53664507
16MP0003878_abnormal_ear_physiology2.53664507
17MP0010030_abnormal_orbit_morphology2.50612171
18MP0002102_abnormal_ear_morphology2.46224773
19MP0005499_abnormal_olfactory_system2.45201935
20MP0005394_taste/olfaction_phenotype2.45201935
21MP0008058_abnormal_DNA_repair2.42900545
22MP0009780_abnormal_chondrocyte_physiolo2.38961539
23MP0009785_altered_susceptibility_to2.33289927
24MP0010094_abnormal_chromosome_stability2.19430444
25MP0003880_abnormal_central_pattern2.13591854
26MP0005451_abnormal_body_composition2.11616460
27MP0005248_abnormal_Harderian_gland2.11460429
28MP0000383_abnormal_hair_follicle2.09419165
29MP0002638_abnormal_pupillary_reflex2.05274207
30MP0001145_abnormal_male_reproductive2.02715086
31MP0002249_abnormal_larynx_morphology1.92254745
32MP0002161_abnormal_fertility/fecundity1.90443525
33MP0002132_abnormal_respiratory_system1.88774987
34MP0000653_abnormal_sex_gland1.87056066
35MP0004782_abnormal_surfactant_physiolog1.84394286
36MP0003693_abnormal_embryo_hatching1.83722154
37MP0002148_abnormal_hypersensitivity_rea1.82472671
38MP0000685_abnormal_immune_system1.78438668
39MP0005397_hematopoietic_system_phenotyp1.73272412
40MP0001545_abnormal_hematopoietic_system1.73272412
41MP0010678_abnormal_skin_adnexa1.72433838
42MP0005623_abnormal_meninges_morphology1.70615427
43MP0002160_abnormal_reproductive_system1.68802960
44MP0003111_abnormal_nucleus_morphology1.67368250
45MP0009764_decreased_sensitivity_to1.64837585
46MP0001485_abnormal_pinna_reflex1.61777298
47MP0005670_abnormal_white_adipose1.58268839
48MP0002419_abnormal_innate_immunity1.56406286
49MP0005646_abnormal_pituitary_gland1.53553829
50MP0002405_respiratory_system_inflammati1.53479869
51MP0005025_abnormal_response_to1.52331070
52MP0001790_abnormal_immune_system1.50014836
53MP0005387_immune_system_phenotype1.50014836
54MP0008007_abnormal_cellular_replicative1.49549177
55MP0003283_abnormal_digestive_organ1.48179325
56MP0000569_abnormal_digit_pigmentation1.47975775
57MP0003436_decreased_susceptibility_to1.47455779
58MP0002233_abnormal_nose_morphology1.46511786
59MP0005671_abnormal_response_to1.46423094
60MP0006292_abnormal_olfactory_placode1.44331845
61MP0002734_abnormal_mechanical_nocicepti1.40774688
62MP0000678_abnormal_parathyroid_gland1.39885975
63MP0002452_abnormal_antigen_presenting1.36751588
64MP0005408_hypopigmentation1.34450828
65MP0006082_CNS_inflammation1.34215785
66MP0000026_abnormal_inner_ear1.31264213
67MP0002723_abnormal_immune_serum1.31166879
68MP0005000_abnormal_immune_tolerance1.30689267
69MP0002282_abnormal_trachea_morphology1.30507610
70MP0001873_stomach_inflammation1.30169367
71MP0001800_abnormal_humoral_immune1.28985646
72MP0003646_muscle_fatigue1.26657282
73MP0008004_abnormal_stomach_pH1.26534329
74MP0005389_reproductive_system_phenotype1.26514983
75MP0002909_abnormal_adrenal_gland1.25555373
76MP0000631_abnormal_neuroendocrine_gland1.25292163
77MP0001765_abnormal_ion_homeostasis1.24357832
78MP0001119_abnormal_female_reproductive1.20850142
79MP0002928_abnormal_bile_duct1.18880317
80MP0009379_abnormal_foot_pigmentation1.17136737
81MP0005647_abnormal_sex_gland1.16927665
82MP0009278_abnormal_bone_marrow1.14304278
83MP0001819_abnormal_immune_cell1.13324698
84MP0005083_abnormal_biliary_tract1.12965824
85MP0002876_abnormal_thyroid_physiology1.12741011
86MP0002420_abnormal_adaptive_immunity1.11587526
87MP0009697_abnormal_copulation1.09650299
88MP0002735_abnormal_chemical_nociception1.08001413
89MP0002277_abnormal_respiratory_mucosa1.06249565
90MP0001486_abnormal_startle_reflex1.06020167
91MP0004381_abnormal_hair_follicle1.04488362
92MP0005636_abnormal_mineral_homeostasis1.03370534
93MP0000955_abnormal_spinal_cord1.01846076
94MP0003763_abnormal_thymus_physiology1.00329267
95MP0000049_abnormal_middle_ear0.99244399
96MP0002234_abnormal_pharynx_morphology0.98977544
97MP0003077_abnormal_cell_cycle0.98801537
98MP0001963_abnormal_hearing_physiology0.98542573
99MP0003890_abnormal_embryonic-extraembry0.97732223
100MP0001845_abnormal_inflammatory_respons0.97552560
101MP0000778_abnormal_nervous_system0.96780761
102MP0004808_abnormal_hematopoietic_stem0.96432445
103MP0001853_heart_inflammation0.95982734
104MP0009046_muscle_twitch0.94290415
105MP0005551_abnormal_eye_electrophysiolog0.93787858
106MP0003186_abnormal_redox_activity0.92200992
107MP0008995_early_reproductive_senescence0.91988259
108MP0001188_hyperpigmentation0.91712717
109MP0003938_abnormal_ear_development0.91555284
110MP0003724_increased_susceptibility_to0.90548315
111MP0003718_maternal_effect0.90367066
112MP0000490_abnormal_crypts_of0.89849090
113MP0005253_abnormal_eye_physiology0.88383233
114MP0002396_abnormal_hematopoietic_system0.87613621
115MP0000372_irregular_coat_pigmentation0.87582781
116MP0003786_premature_aging0.86444220
117MP0002006_tumorigenesis0.85985822
118MP0000716_abnormal_immune_system0.85948897
119MP0002572_abnormal_emotion/affect_behav0.84660404
120MP0002398_abnormal_bone_marrow0.82292868
121MP0002822_catalepsy0.82022139
122MP0003937_abnormal_limbs/digits/tail_de0.80976126
123MP0003861_abnormal_nervous_system0.79975745
124MP0001919_abnormal_reproductive_system0.79544452
125MP0001324_abnormal_eye_pigmentation0.79063673
126MP0002557_abnormal_social/conspecific_i0.78680886
127MP0009745_abnormal_behavioral_response0.78212065
128MP0002067_abnormal_sensory_capabilities0.76027554
129MP0001299_abnormal_eye_distance/0.75201575
130MP0002116_abnormal_craniofacial_bone0.75177029
131MP0003656_abnormal_erythrocyte_physiolo0.75079230
132MP0001270_distended_abdomen0.74411023
133MP0001970_abnormal_pain_threshold0.74361461
134MP0001905_abnormal_dopamine_level0.72044472
135MP0010155_abnormal_intestine_physiology0.71925960
136MP0005310_abnormal_salivary_gland0.70609829
137MP0005391_vision/eye_phenotype0.69681852
138MP0008469_abnormal_protein_level0.69409061
139MP0005195_abnormal_posterior_eye0.69323228
140MP0000858_altered_metastatic_potential0.69134820
141MP0005464_abnormal_platelet_physiology0.68242292
142MP0001764_abnormal_homeostasis0.67927171
143MP0005075_abnormal_melanosome_morpholog0.66942827
144MP0002429_abnormal_blood_cell0.66750868
145MP0002229_neurodegeneration0.66419623
146MP0001346_abnormal_lacrimal_gland0.66338767
147MP0003950_abnormal_plasma_membrane0.65738265
148MP0004859_abnormal_synaptic_plasticity0.65658422
149MP0004885_abnormal_endolymph0.65404285
150MP0002272_abnormal_nervous_system0.64700734
151MP0001293_anophthalmia0.63750426
152MP0005395_other_phenotype0.63659415
153MP0000689_abnormal_spleen_morphology0.63271055
154MP0006276_abnormal_autonomic_nervous0.63222396
155MP0001944_abnormal_pancreas_morphology0.62928966
156MP0008260_abnormal_autophagy0.62773532
157MP0002152_abnormal_brain_morphology0.61845982
158MP0002882_abnormal_neuron_morphology0.61057570
159MP0000566_synostosis0.60571789
160MP0002098_abnormal_vibrissa_morphology0.60240604
161MP0000015_abnormal_ear_pigmentation0.59983161
162MP0005503_abnormal_tendon_morphology0.59748117
163MP0002938_white_spotting0.58783772
164MP0003699_abnormal_female_reproductive0.58195908
165MP0002752_abnormal_somatic_nervous0.57606918
166MP0002722_abnormal_immune_system0.57469116
167MP0000579_abnormal_nail_morphology0.56782264
168MP0000470_abnormal_stomach_morphology0.55207677
169MP0002168_other_aberrant_phenotype0.52903810
170MP0004019_abnormal_vitamin_homeostasis0.49874331

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.81529341
2Abnormal ciliary motility (HP:0012262)9.04866679
3Dynein arm defect of respiratory motile cilia (HP:0012255)8.72144400
4Absent/shortened dynein arms (HP:0200106)8.72144400
5Rhinitis (HP:0012384)8.10603040
6Abnormal respiratory motile cilium morphology (HP:0005938)8.03928282
7Abnormal respiratory epithelium morphology (HP:0012253)8.03928282
8Chronic bronchitis (HP:0004469)6.13705822
9Nasal polyposis (HP:0100582)5.07211330
10Bronchiectasis (HP:0002110)4.94637526
11Recurrent sinusitis (HP:0011108)4.29570664
12Abnormality of the nasal mucosa (HP:0000433)4.02037678
13Bronchitis (HP:0012387)3.83674047
14Nephronophthisis (HP:0000090)3.82772930
15Infertility (HP:0000789)3.60776619
16Tubulointerstitial nephritis (HP:0001970)3.13621349
17Chromosomal breakage induced by crosslinking agents (HP:0003221)3.12213234
18Abnormality of the renal medulla (HP:0100957)3.11421837
19Pancreatic fibrosis (HP:0100732)3.09082246
20Recurrent otitis media (HP:0000403)3.00654128
21True hermaphroditism (HP:0010459)2.95738711
22Chromsome breakage (HP:0040012)2.93022003
23Atelectasis (HP:0100750)2.71555468
24Molar tooth sign on MRI (HP:0002419)2.69278150
25Abnormality of midbrain morphology (HP:0002418)2.69278150
26Bile duct proliferation (HP:0001408)2.67071424
27Abnormal biliary tract physiology (HP:0012439)2.67071424
28Chronic otitis media (HP:0000389)2.60099279
29Chronic sinusitis (HP:0011109)2.54270292
30Congenital hepatic fibrosis (HP:0002612)2.53659141
31Postaxial foot polydactyly (HP:0001830)2.50971185
32Hyperactive renin-angiotensin system (HP:0000841)2.50030518
33Retrobulbar optic neuritis (HP:0100654)2.47451335
34Optic neuritis (HP:0100653)2.47451335
35Chronic hepatic failure (HP:0100626)2.47155370
36Median cleft lip (HP:0000161)2.46185619
37Pancreatic cysts (HP:0001737)2.42157727
38Recurrent abscess formation (HP:0002722)2.40918352
39Abnormal spermatogenesis (HP:0008669)2.31469587
40Recurrent bronchitis (HP:0002837)2.30319530
41Medial flaring of the eyebrow (HP:0010747)2.30285636
42Abnormality of the renal cortex (HP:0011035)2.26844281
43Tubular atrophy (HP:0000092)2.26604285
44Male infertility (HP:0003251)2.22642143
45Cystic liver disease (HP:0006706)2.19807926
46Prostate neoplasm (HP:0100787)2.14144967
47Recurrent gram-negative bacterial infections (HP:0005420)2.13778169
48Tubulointerstitial abnormality (HP:0001969)2.12710737
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.10836675
50Sclerocornea (HP:0000647)2.07288151
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.04304812
52Bell-shaped thorax (HP:0001591)2.03249233
53Orchitis (HP:0100796)2.03059506
54Ectopic kidney (HP:0000086)2.00793049
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.2842725
56Recurrent bacterial skin infections (HP:0005406)1.98523639
57Stage 5 chronic kidney disease (HP:0003774)1.98154817
58Azoospermia (HP:0000027)1.96865224
59Eczematoid dermatitis (HP:0000976)1.88550911
60Occipital encephalocele (HP:0002085)1.88029529
61Abnormality of chromosome stability (HP:0003220)1.87212977
62Myositis (HP:0100614)1.86256422
63Abnormality of the preputium (HP:0100587)1.83015572
64Furrowed tongue (HP:0000221)1.80381515
65Preaxial hand polydactyly (HP:0001177)1.78531587
66Abnormality of permanent molar morphology (HP:0011071)1.78052216
67Abnormality of the dental root (HP:0006486)1.78052216
68Taurodontia (HP:0000679)1.78052216
69Meckel diverticulum (HP:0002245)1.75496199
70Clubbing of toes (HP:0100760)1.75174008
71Oligodactyly (hands) (HP:0001180)1.72957843
72Genital tract atresia (HP:0001827)1.71776278
73Fibular hypoplasia (HP:0003038)1.71548016
74Polydipsia (HP:0001959)1.71461968
75Abnormal drinking behavior (HP:0030082)1.71461968
76Abnormality of the dental pulp (HP:0006479)1.71070540
77Abnormality of molar (HP:0011077)1.70954309
78Abnormality of molar morphology (HP:0011070)1.70954309
79Gonadotropin excess (HP:0000837)1.70673474
80Vaginal atresia (HP:0000148)1.67511646
81Abnormality of the ileum (HP:0001549)1.67313419
82Abnormality of dentin (HP:0010299)1.67034524
83Chronic obstructive pulmonary disease (HP:0006510)1.66425612
84Obstructive lung disease (HP:0006536)1.66425612
85Poor coordination (HP:0002370)1.65473035
86Supernumerary spleens (HP:0009799)1.64035837
87Mediastinal lymphadenopathy (HP:0100721)1.63004667
88Hyperkalemia (HP:0002153)1.62633099
89Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60293777
90Congenital primary aphakia (HP:0007707)1.58602342
91Facial cleft (HP:0002006)1.58073336
92Decreased circulating renin level (HP:0003351)1.57300292
93Renal salt wasting (HP:0000127)1.55184706
94Male pseudohermaphroditism (HP:0000037)1.53692712
95Short nail (HP:0001799)1.53575671
96Gait imbalance (HP:0002141)1.50449712
97Recurrent pneumonia (HP:0006532)1.50364125
98Autoimmune thrombocytopenia (HP:0001973)1.49810726
99Anencephaly (HP:0002323)1.47382725
100Nephrogenic diabetes insipidus (HP:0009806)1.46600913
101Sloping forehead (HP:0000340)1.46096241
102Decreased central vision (HP:0007663)1.45457508
103Aplasia/Hypoplasia of the spleen (HP:0010451)1.43713008
104Postaxial hand polydactyly (HP:0001162)1.43619147
105Asplenia (HP:0001746)1.41823946
106Pendular nystagmus (HP:0012043)1.40886940
107Microglossia (HP:0000171)1.40402328
108Nephropathy (HP:0000112)1.39882972
109Absent frontal sinuses (HP:0002688)1.39435851
110Duplicated collecting system (HP:0000081)1.38391837
111Abnormality of the prostate (HP:0008775)1.38085962
112Keratoconjunctivitis (HP:0001096)1.37982757
113Oculomotor apraxia (HP:0000657)1.37885351
114Alveolar cell carcinoma (HP:0006519)1.37726056
115Duodenal stenosis (HP:0100867)1.37323115
116Small intestinal stenosis (HP:0012848)1.37323115
117Hyperaldosteronism (HP:0000859)1.28271582
118Abnormal rod and cone electroretinograms (HP:0008323)1.27402227
119Narrow forehead (HP:0000341)1.25976993
120Absent rod-and cone-mediated responses on ERG (HP:0007688)1.20895369
121Aplasia/Hypoplasia of the lens (HP:0008063)1.20119613
122Abnormality of renin-angiotensin system (HP:0000847)1.19567821
123Short thorax (HP:0010306)1.19032093
124Abnormality of macular pigmentation (HP:0008002)1.17833757
125Renal dysplasia (HP:0000110)1.17183776
126Tubulointerstitial fibrosis (HP:0005576)1.16087302
127Cone-rod dystrophy (HP:0000548)1.14838853
128Abnormality of chloride homeostasis (HP:0011422)1.13398006
129Prominent nasal bridge (HP:0000426)1.12812800
130Bifid scrotum (HP:0000048)1.10837033
131Retinitis pigmentosa (HP:0000510)1.07452856
132Hand muscle atrophy (HP:0009130)1.07326128
133Aplasia of the musculature (HP:0100854)1.07276482
134Aganglionic megacolon (HP:0002251)1.06858436
135Multicystic kidney dysplasia (HP:0000003)1.05684051
136Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.04207811
137Absent speech (HP:0001344)1.01101391
138Holoprosencephaly (HP:0001360)1.00771391
139Fetal akinesia sequence (HP:0001989)0.99933560
140Short ribs (HP:0000773)0.99753776
141Highly arched eyebrow (HP:0002553)0.99548443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK34.75727176
2PDK44.75727176
3PDK23.41376193
4MAP3K142.86870132
5MAPK152.80576415
6IRAK32.46898770
7PNCK2.31422825
8NEK22.30457349
9TXK2.21103442
10GRK12.07409085
11TESK12.04405881
12PLK42.01455032
13EIF2AK21.84172409
14IRAK41.82690134
15MAP3K21.81745861
16NME11.80218770
17STK38L1.79976523
18PRKD31.73418085
19TTK1.66658663
20WEE11.65497433
21ZAK1.65141179
22PIM21.62748259
23EPHA31.54484887
24TEC1.51556999
25BCR1.47612449
26PASK1.46397032
27TAOK31.44709507
28MAP3K41.44008236
29MAPKAPK31.43373259
30STK31.42111734
31EPHA41.37147677
32CDC71.26877867
33STK161.25805395
34ATR1.25240427
35PIM11.24699367
36IRAK11.21055495
37VRK11.19775310
38MAP3K71.19680943
39TBK11.19401256
40CHEK21.19338974
41NEK91.18377814
42MAP3K121.16467779
43MAP4K11.13168889
44YES11.12626765
45IKBKE1.12304083
46BMPR1B1.12201290
47MAP4K21.10226254
48TSSK61.09987684
49TNIK1.09958192
50CDK31.09396249
51MKNK21.07889917
52NLK1.04658393
53NEK61.02399959
54DYRK31.01667775
55JAK30.99667039
56ERBB30.98212017
57JAK10.97818425
58TYK20.96988463
59MST40.95677299
60IKBKB0.95629970
61BMPR20.95350919
62PTK2B0.92418031
63PINK10.89499756
64TLK10.89405859
65RIPK40.88159136
66TIE10.86446600
67PLK10.84363561
68TRPM70.83883499
69BLK0.82491866
70MAP2K40.81779373
71MAP3K90.81095622
72NME20.80342760
73STK100.80206925
74LRRK20.78819182
75NUAK10.78531312
76MAP2K70.78292967
77MET0.77810922
78EPHB10.75960345
79ARAF0.74564823
80ATM0.73668337
81MST1R0.73624606
82ICK0.72456545
83CHUK0.71280286
84CHEK10.70878225
85SRPK10.68983343
86NTRK30.68458159
87MARK10.68058711
88MAP3K30.67480623
89LYN0.67292068
90ADRBK20.66818699
91CDK80.66067259
92MARK20.63616222
93AURKA0.63432783
94CDK40.62319820
95LATS10.62318369
96PIK3CG0.61632330
97CDK190.60959727
98STK40.60317000
99INSRR0.58766522
100EPHA20.56274291
101RPS6KA40.56250114
102STK240.55875300
103BTK0.55612644
104AURKB0.55473354
105WNK30.54802869
106ERBB40.53749308
107SYK0.53167507
108NTRK20.52149868
109CAMK1G0.51784046
110PRKCI0.51605046
111PRPF4B0.51502865
112MUSK0.49983331
113CSK0.49540387
114KIT0.49497071
115CASK0.49059147
116TNK20.49004259
117OXSR10.48369926
118PBK0.47559519
119ABL10.47175993
120CDK90.46819003
121CDK70.46337641
122MKNK10.46217224
123PDK10.46061862
124CDC42BPA0.45782026
125SGK10.45241813
126STK390.45101978
127ADRBK10.44944002
128ROCK10.44362081
129BRD40.43583577
130MELK0.43171029
131DYRK1B0.41878015
132ROCK20.38620166
133MAPK130.38328297
134CDK60.38087806
135PRKACA0.37562693
136PRKCD0.37164081
137STK380.36893643
138CAMKK10.36876504
139LIMK10.35862413
140DYRK1A0.35743956
141PRKCG0.34114036
142CSNK2A10.33584378
143CCNB10.33482960
144CAMK2A0.32480086
145WNK40.32043492
146PLK20.31737756
147BMX0.31129490
148PRKCZ0.30534226
149PRKCQ0.29368305
150MAP2K20.25590141
151PAK30.25218474
152PRKG10.24000009
153SGK2230.23350606
154SGK4940.23350606
155ERBB20.22323763
156CSNK1E0.22237303
157MAP3K110.22182173
158ACVR1B0.21091773
159PRKCA0.20459901
160FER0.20067048
161PRKAA20.19735326
162MAP2K10.19636263

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.00655049
2Fanconi anemia pathway_Homo sapiens_hsa034603.48708845
3Vitamin B6 metabolism_Homo sapiens_hsa007503.36002812
4Tyrosine metabolism_Homo sapiens_hsa003503.11503947
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91639435
6Basal transcription factors_Homo sapiens_hsa030222.63935322
7Homologous recombination_Homo sapiens_hsa034402.55090093
8Graft-versus-host disease_Homo sapiens_hsa053322.46338933
9Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.35557014
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.17717147
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15606774
12Caffeine metabolism_Homo sapiens_hsa002322.09943825
13Non-homologous end-joining_Homo sapiens_hsa034502.04964910
14Intestinal immune network for IgA production_Homo sapiens_hsa046722.04188213
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.01285156
16Allograft rejection_Homo sapiens_hsa053301.99676409
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81952046
18DNA replication_Homo sapiens_hsa030301.79195661
19Measles_Homo sapiens_hsa051621.78107769
20Legionellosis_Homo sapiens_hsa051341.77332030
21Base excision repair_Homo sapiens_hsa034101.70260956
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.62459408
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.56320027
24Autoimmune thyroid disease_Homo sapiens_hsa053201.56041575
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.53776859
26Nicotine addiction_Homo sapiens_hsa050331.53539110
27Malaria_Homo sapiens_hsa051441.52998268
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.52529474
29Leishmaniasis_Homo sapiens_hsa051401.52383901
30Herpes simplex infection_Homo sapiens_hsa051681.48930724
31Cell cycle_Homo sapiens_hsa041101.48021398
32Linoleic acid metabolism_Homo sapiens_hsa005911.44817538
33Asthma_Homo sapiens_hsa053101.41403496
34Hedgehog signaling pathway_Homo sapiens_hsa043401.40935098
35Hematopoietic cell lineage_Homo sapiens_hsa046401.37971116
36Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36993805
37Rheumatoid arthritis_Homo sapiens_hsa053231.36960185
38Taste transduction_Homo sapiens_hsa047421.35309032
39Primary immunodeficiency_Homo sapiens_hsa053401.31981442
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31507533
41Tight junction_Homo sapiens_hsa045301.30088566
42RNA degradation_Homo sapiens_hsa030181.29194318
43Antigen processing and presentation_Homo sapiens_hsa046121.28776851
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.28406483
45Arachidonic acid metabolism_Homo sapiens_hsa005901.26526159
46Nucleotide excision repair_Homo sapiens_hsa034201.26477573
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.26214866
48Influenza A_Homo sapiens_hsa051641.24635365
49Pyrimidine metabolism_Homo sapiens_hsa002401.23027423
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22867804
51Peroxisome_Homo sapiens_hsa041461.19836068
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.19456902
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19445567
54Purine metabolism_Homo sapiens_hsa002301.18784234
55Basal cell carcinoma_Homo sapiens_hsa052171.18696185
56Butanoate metabolism_Homo sapiens_hsa006501.17544774
57Type I diabetes mellitus_Homo sapiens_hsa049401.15029851
58TNF signaling pathway_Homo sapiens_hsa046681.14710002
59Jak-STAT signaling pathway_Homo sapiens_hsa046301.14228010
60Mismatch repair_Homo sapiens_hsa034301.09329166
61Collecting duct acid secretion_Homo sapiens_hsa049661.06726548
62p53 signaling pathway_Homo sapiens_hsa041151.03925723
63Phototransduction_Homo sapiens_hsa047441.03696943
64Salivary secretion_Homo sapiens_hsa049701.03659770
65Olfactory transduction_Homo sapiens_hsa047401.03591461
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03015189
67Nitrogen metabolism_Homo sapiens_hsa009101.02881196
68Cardiac muscle contraction_Homo sapiens_hsa042601.02798866
69Oxidative phosphorylation_Homo sapiens_hsa001901.02630733
70Fatty acid degradation_Homo sapiens_hsa000711.02233644
71Sphingolipid metabolism_Homo sapiens_hsa006000.97745359
72African trypanosomiasis_Homo sapiens_hsa051430.97011346
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95862573
74Vitamin digestion and absorption_Homo sapiens_hsa049770.94262600
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91981004
76Circadian rhythm_Homo sapiens_hsa047100.90326806
77Osteoclast differentiation_Homo sapiens_hsa043800.89931651
78Axon guidance_Homo sapiens_hsa043600.89356675
79Ether lipid metabolism_Homo sapiens_hsa005650.87914584
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87013280
81Steroid biosynthesis_Homo sapiens_hsa001000.83277648
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81454047
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80684858
84Staphylococcus aureus infection_Homo sapiens_hsa051500.80043873
85Cocaine addiction_Homo sapiens_hsa050300.79835576
86Pentose phosphate pathway_Homo sapiens_hsa000300.79635959
87Dorso-ventral axis formation_Homo sapiens_hsa043200.77554947
88Starch and sucrose metabolism_Homo sapiens_hsa005000.76980666
89Fatty acid biosynthesis_Homo sapiens_hsa000610.76962872
90Tuberculosis_Homo sapiens_hsa051520.76670304
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76332345
92Phagosome_Homo sapiens_hsa041450.74851152
93cAMP signaling pathway_Homo sapiens_hsa040240.74196897
94Pertussis_Homo sapiens_hsa051330.73537306
95Glutathione metabolism_Homo sapiens_hsa004800.73450220
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.73156694
97Selenocompound metabolism_Homo sapiens_hsa004500.73103116
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71332116
99Epstein-Barr virus infection_Homo sapiens_hsa051690.70858118
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.67947698
101Salmonella infection_Homo sapiens_hsa051320.67725030
102Retinol metabolism_Homo sapiens_hsa008300.67685337
103ABC transporters_Homo sapiens_hsa020100.65446861
104Chemical carcinogenesis_Homo sapiens_hsa052040.65206316
105Insulin secretion_Homo sapiens_hsa049110.64360740
106Systemic lupus erythematosus_Homo sapiens_hsa053220.63821545
107Serotonergic synapse_Homo sapiens_hsa047260.62711408
108RNA transport_Homo sapiens_hsa030130.62254468
109Histidine metabolism_Homo sapiens_hsa003400.61055267
110Toxoplasmosis_Homo sapiens_hsa051450.60311932
111Amphetamine addiction_Homo sapiens_hsa050310.60082239
112Apoptosis_Homo sapiens_hsa042100.60037569
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57313664
114Hepatitis B_Homo sapiens_hsa051610.57000486
115Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56751707
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.55465393
117Alzheimers disease_Homo sapiens_hsa050100.55391486
118Metabolic pathways_Homo sapiens_hsa011000.55134582
119Notch signaling pathway_Homo sapiens_hsa043300.55038859
120Huntingtons disease_Homo sapiens_hsa050160.54679463
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54006805
122Viral carcinogenesis_Homo sapiens_hsa052030.53934477
123Parkinsons disease_Homo sapiens_hsa050120.53397615
124B cell receptor signaling pathway_Homo sapiens_hsa046620.53108304
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.52619920
126Propanoate metabolism_Homo sapiens_hsa006400.52142159
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52129544
128Arginine and proline metabolism_Homo sapiens_hsa003300.51686795
129HTLV-I infection_Homo sapiens_hsa051660.50939747
130Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50451197
131Synaptic vesicle cycle_Homo sapiens_hsa047210.50188911
132Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49933187
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49009075
134Ovarian steroidogenesis_Homo sapiens_hsa049130.48987639
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48453834
136PPAR signaling pathway_Homo sapiens_hsa033200.48059261
137Regulation of autophagy_Homo sapiens_hsa041400.46375829
138Hippo signaling pathway_Homo sapiens_hsa043900.46277909
139Proteasome_Homo sapiens_hsa030500.45460376
140Calcium signaling pathway_Homo sapiens_hsa040200.44417838
141Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42902709
142Glutamatergic synapse_Homo sapiens_hsa047240.42671934
143Mineral absorption_Homo sapiens_hsa049780.42505680
144Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41920697
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39961730
146One carbon pool by folate_Homo sapiens_hsa006700.39577132
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39278214
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.38983368
149Choline metabolism in cancer_Homo sapiens_hsa052310.37766416
150mRNA surveillance pathway_Homo sapiens_hsa030150.37199806
151Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36915719
152Pyruvate metabolism_Homo sapiens_hsa006200.34114114
153Protein export_Homo sapiens_hsa030600.34096010
154beta-Alanine metabolism_Homo sapiens_hsa004100.31829133
155T cell receptor signaling pathway_Homo sapiens_hsa046600.31581793
156Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.31105359
157Pancreatic secretion_Homo sapiens_hsa049720.29696765
158Wnt signaling pathway_Homo sapiens_hsa043100.28352492
159Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26436279
160Melanogenesis_Homo sapiens_hsa049160.26252994
161Tryptophan metabolism_Homo sapiens_hsa003800.25065427
162Circadian entrainment_Homo sapiens_hsa047130.22231776
163Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.20701801
164Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20134860
165Dopaminergic synapse_Homo sapiens_hsa047280.20031013
166Type II diabetes mellitus_Homo sapiens_hsa049300.19908675
167Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.19801094
168Oxytocin signaling pathway_Homo sapiens_hsa049210.19297922
169N-Glycan biosynthesis_Homo sapiens_hsa005100.19159818

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