CFAP52

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: WD repeat-containing proteins, such as WDR16, play crucial roles in a wide range of physiologic functions, including signal transduction, RNA processing, remodeling the cytoskeleton, regulation of vesicular traffic, and cell division (Silva et al., 2005 [PubMed 15967112]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1motile cilium assembly (GO:0044458)9.69350719
2ventricular system development (GO:0021591)9.05890201
3GTP biosynthetic process (GO:0006183)8.91904790
4sperm motility (GO:0030317)8.47176291
5nucleoside diphosphate phosphorylation (GO:0006165)8.02347439
6UTP biosynthetic process (GO:0006228)7.94471223
7fusion of sperm to egg plasma membrane (GO:0007342)7.88576608
8regulation of cilium movement (GO:0003352)7.60056174
9UTP metabolic process (GO:0046051)7.42993627
10acrosome assembly (GO:0001675)7.40822591
11sperm-egg recognition (GO:0035036)6.99127989
12multicellular organism reproduction (GO:0032504)6.85924853
13left/right axis specification (GO:0070986)6.59394564
14acrosome reaction (GO:0007340)6.53694230
15spermatid development (GO:0007286)6.47578396
16piRNA metabolic process (GO:0034587)6.38886384
17binding of sperm to zona pellucida (GO:0007339)6.38671240
18cell wall macromolecule metabolic process (GO:0044036)6.20481836
19cell wall macromolecule catabolic process (GO:0016998)6.20481836
20cell-cell recognition (GO:0009988)6.18681709
21primary alcohol catabolic process (GO:0034310)6.10317791
22plasma membrane fusion (GO:0045026)6.01439247
23negative regulation of inclusion body assembly (GO:0090084)6.01040175
24guanosine-containing compound biosynthetic process (GO:1901070)6.00591743
25male meiosis (GO:0007140)5.78441247
26CTP metabolic process (GO:0046036)5.76002460
27CTP biosynthetic process (GO:0006241)5.76002460
28synaptonemal complex organization (GO:0070193)5.69145510
29reproduction (GO:0000003)5.53129000
30vitamin transmembrane transport (GO:0035461)5.47331662
31intraciliary transport (GO:0042073)5.30095844
32pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)5.25611333
33microtubule bundle formation (GO:0001578)5.24250100
34single fertilization (GO:0007338)5.21064176
35ethanol metabolic process (GO:0006067)5.15030654
36microtubule severing (GO:0051013)5.08119567
37cilium organization (GO:0044782)5.07871192
38pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)5.03806879
39diterpenoid biosynthetic process (GO:0016102)4.87459963
40regulation of microtubule-based movement (GO:0060632)4.77095409
41cilium assembly (GO:0042384)4.72795060
42regulation of inclusion body assembly (GO:0090083)4.64221661
43fertilization (GO:0009566)4.61510781
44synaptonemal complex assembly (GO:0007130)4.57471582
45pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)4.53923167
46response to xenobiotic stimulus (GO:0009410)4.51675510
47nucleotide phosphorylation (GO:0046939)4.50017444
48microtubule-based movement (GO:0007018)4.49605656
49negative regulation of T cell differentiation in thymus (GO:0033085)4.43882544
50lung epithelium development (GO:0060428)4.40606070
51spermatogenesis (GO:0007283)4.40418244
52cellular component assembly involved in morphogenesis (GO:0010927)4.40374047
53cilium morphogenesis (GO:0060271)4.39930218
54male gamete generation (GO:0048232)4.38423468
55male meiosis I (GO:0007141)4.33765470
56pyrimidine-containing compound transmembrane transport (GO:0072531)4.31415192
57sperm capacitation (GO:0048240)4.25345797
58tolerance induction (GO:0002507)4.20473386
59spermatid nucleus differentiation (GO:0007289)4.18062853
60DNA methylation involved in gamete generation (GO:0043046)4.12006048
61pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.07716783
62gamete generation (GO:0007276)4.02893396
63glomerular epithelial cell development (GO:0072310)4.02491668
64meiotic cell cycle (GO:0051321)3.96000273
65nucleoside diphosphate metabolic process (GO:0009132)3.95629249
66establishment of apical/basal cell polarity (GO:0035089)3.94953666
67negative regulation of B cell mediated immunity (GO:0002713)3.87114780
68negative regulation of immunoglobulin mediated immune response (GO:0002890)3.87114780
69lateral ventricle development (GO:0021670)3.86623114
70ethanol oxidation (GO:0006069)3.86534620
71regulation of interleukin-5 production (GO:0032674)3.86050873
72left/right pattern formation (GO:0060972)3.80420312
73one-carbon compound transport (GO:0019755)3.67738492
74establishment or maintenance of monopolar cell polarity (GO:0061339)3.63892436
75establishment of monopolar cell polarity (GO:0061162)3.63892436
76negative regulation of humoral immune response (GO:0002921)3.63500887
77germ cell development (GO:0007281)3.59344276
78retinoic acid metabolic process (GO:0042573)3.58712327
79cell projection assembly (GO:0030031)3.52716866
80protein localization to cilium (GO:0061512)3.51467968
81terpenoid biosynthetic process (GO:0016114)3.50870435
82regulation of germinal center formation (GO:0002634)3.48763423
83exogenous drug catabolic process (GO:0042738)3.47117659
84cytoplasmic microtubule organization (GO:0031122)3.46887497
85microtubule polymerization or depolymerization (GO:0031109)3.46231695
86cellular process involved in reproduction in multicellular organism (GO:0022412)3.45301935
87smoothened signaling pathway (GO:0007224)3.44025908
88centriole assembly (GO:0098534)3.36404799
89meiosis I (GO:0007127)3.34480132
90organic cation transport (GO:0015695)3.31319072
91regulation of macrophage chemotaxis (GO:0010758)3.30844497
92regulation of interleukin-13 production (GO:0032656)3.29144193
93protein polyglutamylation (GO:0018095)3.26756466
94regulation of mononuclear cell migration (GO:0071675)3.25977004
95glutathione derivative biosynthetic process (GO:1901687)3.24382317
96glutathione derivative metabolic process (GO:1901685)3.24382317
97positive regulation of tolerance induction (GO:0002645)3.22981574
98pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.22328280
99multicellular organismal reproductive process (GO:0048609)3.21414389
100cell recognition (GO:0008037)3.20345915
101establishment of tissue polarity (GO:0007164)3.19003911
102establishment of planar polarity (GO:0001736)3.19003911
103regulation of glucose import in response to insulin stimulus (GO:2001273)3.17992373
104calcium ion-dependent exocytosis (GO:0017156)3.12657283
105pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.07828260
106chromosome organization involved in meiosis (GO:0070192)3.07598940
107meiotic nuclear division (GO:0007126)3.05938876
108protein refolding (GO:0042026)3.03608331
109brain morphogenesis (GO:0048854)3.01499419
110aldehyde catabolic process (GO:0046185)2.95038924
111lateral sprouting from an epithelium (GO:0060601)2.93272113
112negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.92707040
113retinal rod cell development (GO:0046548)2.91539179
114purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.89393919
115pyrimidine ribonucleotide metabolic process (GO:0009218)2.89290947
116regulation of meiosis I (GO:0060631)2.87642482
117primary alcohol metabolic process (GO:0034308)2.86174614
118retinol metabolic process (GO:0042572)2.85705177
119microtubule-based process (GO:0007017)2.83389751
120nonmotile primary cilium assembly (GO:0035058)2.81948850
121muscle organ morphogenesis (GO:0048644)2.81263650
122purine nucleoside triphosphate biosynthetic process (GO:0009145)2.79760432
123microtubule depolymerization (GO:0007019)2.78895515
124positive regulation of smoothened signaling pathway (GO:0045880)2.78844146
125carnitine metabolic process (GO:0009437)2.76888179
126hydrogen peroxide biosynthetic process (GO:0050665)2.76547726
127organelle assembly (GO:0070925)2.74982724
128determination of left/right symmetry (GO:0007368)2.74313074
129photoreceptor cell differentiation (GO:0046530)2.72341587
130eye photoreceptor cell differentiation (GO:0001754)2.72341587
131drug catabolic process (GO:0042737)2.71948837
132apical protein localization (GO:0045176)2.69021719
133centriole replication (GO:0007099)2.68228676
134determination of bilateral symmetry (GO:0009855)2.66730910
135specification of symmetry (GO:0009799)2.62814766
136cerebral cortex neuron differentiation (GO:0021895)2.62444758
137O-glycan processing (GO:0016266)2.60493459
138photoreceptor cell maintenance (GO:0045494)2.60465414
139axon ensheathment in central nervous system (GO:0032291)2.58376156
140central nervous system myelination (GO:0022010)2.58376156
141chaperone-mediated protein complex assembly (GO:0051131)2.56702385
142regulation of autophagic vacuole assembly (GO:2000785)2.56345797
143nucleoside triphosphate biosynthetic process (GO:0009142)2.55011846
144regulation of collateral sprouting (GO:0048670)2.54004716
145heart looping (GO:0001947)2.46604743
146phosphatidylcholine biosynthetic process (GO:0006656)2.45568481
147reactive oxygen species biosynthetic process (GO:1903409)2.42943293
148cornea development in camera-type eye (GO:0061303)2.39274323
149regulation of smoothened signaling pathway (GO:0008589)2.37688491
150phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.37203698
151intra-S DNA damage checkpoint (GO:0031573)2.33229557
152excretion (GO:0007588)2.32470322
153regulation of microtubule depolymerization (GO:0031114)2.30837868
154CDP-diacylglycerol biosynthetic process (GO:0016024)2.28917543
155embryonic heart tube morphogenesis (GO:0003143)2.28449827
156regulation of vacuole organization (GO:0044088)2.27458358
157asymmetric protein localization (GO:0008105)2.27444129
158cilium or flagellum-dependent cell motility (GO:0001539)15.8865181
159axonemal dynein complex assembly (GO:0070286)15.2982465
160cilium movement (GO:0003341)15.1945944
161epithelial cilium movement (GO:0003351)12.7787742
162axoneme assembly (GO:0035082)11.5682613
163epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.0246535

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11639675
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.84023868
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.03891431
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.45182286
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.14816173
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97523845
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.85638833
8PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.43668328
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.36107534
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.29971157
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.24455871
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.24441117
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.08436028
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00811803
15GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96951443
16PCGF2_27294783_Chip-Seq_ESCs_Mouse1.93064474
17SUZ12_27294783_Chip-Seq_NPCs_Mouse1.85415915
18VDR_22108803_ChIP-Seq_LS180_Human1.78121402
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.73784951
20AHR_22903824_ChIP-Seq_MCF-7_Human1.69981187
21ESR1_20079471_ChIP-ChIP_T-47D_Human1.69245756
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.66817896
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.66739818
24TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65758378
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.64133199
26FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62507309
27RNF2_27304074_Chip-Seq_NSC_Mouse1.61001757
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.60377487
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.59769021
30KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.53132581
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52715033
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51100223
33SMAD4_21799915_ChIP-Seq_A2780_Human1.50562065
34STAT1_20625510_ChIP-Seq_HELA_Human1.49653734
35FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.47709203
36TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43784396
37TP63_23658742_ChIP-Seq_EP156T_Human1.43523951
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.42719000
39POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41798690
40TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41798690
41ZFP57_27257070_Chip-Seq_ESCs_Mouse1.41290079
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.41249301
43CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40571793
44MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39709409
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.39583461
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39053181
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38709573
48WDR5_24793694_ChIP-Seq_LNCAP_Human1.38695817
49AR_21572438_ChIP-Seq_LNCaP_Human1.37908923
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.37717301
51TP53_18474530_ChIP-ChIP_U2OS_Human1.37494394
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37113220
53TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.35916552
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35522090
55ETV1_20927104_ChIP-Seq_GIST48_Human1.35407161
56TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.33951395
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32574146
58SMRT_27268052_Chip-Seq_Bcells_Human1.31972760
59PHF8_20622853_ChIP-Seq_HELA_Human1.30897386
60IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30413716
61CBP_20019798_ChIP-Seq_JUKART_Human1.30413716
62REST_21632747_ChIP-Seq_MESCs_Mouse1.29752506
63BCAT_22108803_ChIP-Seq_LS180_Human1.29412105
64CRX_20693478_ChIP-Seq_RETINA_Mouse1.29143326
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29122133
66TCF4_22108803_ChIP-Seq_LS180_Human1.28453770
67P53_22387025_ChIP-Seq_ESCs_Mouse1.27283066
68OCT4_18555785_Chip-Seq_ESCs_Mouse1.27173202
69SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26657024
70CTNNB1_20460455_ChIP-Seq_HCT116_Human1.26630428
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25860167
72STAT3_18555785_Chip-Seq_ESCs_Mouse1.25160230
73PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.24472321
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.24073244
75STAT3_23295773_ChIP-Seq_U87_Human1.23435630
76TAL1_26923725_Chip-Seq_HPCs_Mouse1.23305287
77TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22887058
78ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22829494
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22011864
80HNFA_21074721_ChIP-Seq_CACO-2_Human1.21922867
81EZH2_27294783_Chip-Seq_NPCs_Mouse1.21698735
82EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.20871268
83P300_18555785_Chip-Seq_ESCs_Mouse1.19833440
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.19611592
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.19049243
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.18299472
87ZFX_18555785_Chip-Seq_ESCs_Mouse1.18051604
88ESRRB_18555785_Chip-Seq_ESCs_Mouse1.17897002
89SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17753549
90SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.17477755
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17441508
92RUNX1_27514584_Chip-Seq_MCF-7_Human1.17066358
93STAT1_17558387_ChIP-Seq_HELA_Human1.16896969
94TBL1_22424771_ChIP-Seq_293T_Human1.16843511
95KDM2B_26808549_Chip-Seq_REH_Human1.16136667
96SOX2_18555785_Chip-Seq_ESCs_Mouse1.15826833
97DROSHA_22980978_ChIP-Seq_HELA_Human1.14943840
98NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14010262
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13972434
100SUZ12_18555785_Chip-Seq_ESCs_Mouse1.13922215
101OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13847003
102FOXA1_25552417_ChIP-Seq_VCAP_Human1.13401174
103PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13118165
104SOX2_22085726_ChIP-Seq_NPCs_Mouse1.13093475
105RAD21_21589869_ChIP-Seq_MESCs_Mouse1.12312513
106TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12173253
107KLF4_18555785_Chip-Seq_ESCs_Mouse1.11331449
108TRIM28_21343339_ChIP-Seq_HEK293_Human1.10844367
109RBPJ_21746931_ChIP-Seq_IB4_Human1.10303081
110ESR2_21235772_ChIP-Seq_MCF-7_Human1.10167827
111NFYA_21822215_ChIP-Seq_K562_Human1.09778699
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.09578814
113SMC4_20622854_ChIP-Seq_HELA_Human1.09325632
114KLF5_25053715_ChIP-Seq_YYC3_Human1.08939548
115GBX2_23144817_ChIP-Seq_PC3_Human1.08283515
116PU1_27457419_Chip-Seq_LIVER_Mouse1.07761732
117EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07758628
118SMAD3_21741376_ChIP-Seq_HESCs_Human1.07178028
119POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06765265
120TP63_22573176_ChIP-Seq_HFKS_Human1.06735767
121ZNF274_21170338_ChIP-Seq_K562_Hela1.06544003
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06445519
123AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06418933
124SMAD4_21741376_ChIP-Seq_EPCs_Human1.06263486
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.05678276
126CBX2_22325352_ChIP-Seq_293T-Rex_Human1.05650849
127P300_19829295_ChIP-Seq_ESCs_Human1.05503032
128CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05398850
129NFYB_21822215_ChIP-Seq_K562_Human1.05092779
130GF1_26923725_Chip-Seq_HPCs_Mouse1.05036151
131ER_23166858_ChIP-Seq_MCF-7_Human1.04635374
132CTCF_18555785_Chip-Seq_ESCs_Mouse1.04118430
133TCF4_23295773_ChIP-Seq_U87_Human1.04106934
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04049930
135SOX2_27498859_Chip-Seq_STOMACH_Mouse1.03573331
136FUS_26573619_Chip-Seq_HEK293_Human1.03455429
137CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.03157031
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02659663
139LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02420370
140GATA6_21074721_ChIP-Seq_CACO-2_Human1.02208538
141PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02121746
142AR_20517297_ChIP-Seq_VCAP_Human1.01890844
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01267851
144CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01181043
145SMAD3_21741376_ChIP-Seq_EPCs_Human1.01083683
146SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.00987021
147RUNX2_22187159_ChIP-Seq_PCA_Human1.00186658
148RUNX1_27457419_Chip-Seq_LIVER_Mouse1.00035353
149BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99523664
150TP53_16413492_ChIP-PET_HCT116_Human0.98739944
151FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98358646
152FOXA1_25329375_ChIP-Seq_VCAP_Human0.98358646
153NMYC_18555785_Chip-Seq_ESCs_Mouse0.97825326
154GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97068852
155GF1B_26923725_Chip-Seq_HPCs_Mouse0.96956622
156CEBPB_22108803_ChIP-Seq_LS180_Human0.96581908
157SOX2_20726797_ChIP-Seq_SW620_Human0.94059964
158SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93287212
159CDX2_20551321_ChIP-Seq_CACO-2_Human0.92553938
160BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91808031
161SMAD4_21741376_ChIP-Seq_HESCs_Human0.90865733
162TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.90852536
163AR_25329375_ChIP-Seq_VCAP_Human0.90582532
164GATA4_25053715_ChIP-Seq_YYC3_Human0.90310007

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology5.39126534
2MP0003698_abnormal_male_reproductive4.45040683
3MP0003136_yellow_coat_color4.22737801
4MP0001929_abnormal_gametogenesis4.01797296
5MP0002132_abnormal_respiratory_system3.84655325
6MP0005623_abnormal_meninges_morphology3.47586324
7MP0000566_synostosis3.34534040
8MP0004043_abnormal_pH_regulation3.23685174
9MP0002277_abnormal_respiratory_mucosa3.20848163
10MP0008877_abnormal_DNA_methylation3.10941164
11MP0008789_abnormal_olfactory_epithelium2.92437482
12MP0009780_abnormal_chondrocyte_physiolo2.90508117
13MP0002210_abnormal_sex_determination2.72959216
14MP0001984_abnormal_olfaction2.51342719
15MP0002282_abnormal_trachea_morphology2.40159703
16MP0002160_abnormal_reproductive_system2.37553892
17MP0002161_abnormal_fertility/fecundity2.30442368
18MP0001145_abnormal_male_reproductive2.14263104
19MP0001440_abnormal_grooming_behavior2.09491361
20MP0002102_abnormal_ear_morphology2.08291902
21MP0005646_abnormal_pituitary_gland2.04298969
22MP0005410_abnormal_fertilization10.5302987
23MP0005499_abnormal_olfactory_system1.98889011
24MP0005394_taste/olfaction_phenotype1.98889011
25MP0004133_heterotaxia1.97767712
26MP0000653_abnormal_sex_gland1.86403955
27MP0009046_muscle_twitch1.81567600
28MP0008995_early_reproductive_senescence1.72983713
29MP0002638_abnormal_pupillary_reflex1.72059419
30MP0002249_abnormal_larynx_morphology1.62335847
31MP0008004_abnormal_stomach_pH1.58792386
32MP0004742_abnormal_vestibular_system1.56622292
33MP0005670_abnormal_white_adipose1.51234912
34MP0001485_abnormal_pinna_reflex1.49174809
35MP0002909_abnormal_adrenal_gland1.45204491
36MP0005389_reproductive_system_phenotype1.34517206
37MP0002876_abnormal_thyroid_physiology1.24075160
38MP0003656_abnormal_erythrocyte_physiolo1.17655869
39MP0003634_abnormal_glial_cell1.16975709
40MP0001346_abnormal_lacrimal_gland1.16594777
41MP0002928_abnormal_bile_duct1.13376281
42MP0010030_abnormal_orbit_morphology1.12745254
43MP0000579_abnormal_nail_morphology1.12527462
44MP0005551_abnormal_eye_electrophysiolog1.11077878
45MP0001661_extended_life_span1.08417534
46MP0004858_abnormal_nervous_system1.08155040
47MP0004885_abnormal_endolymph1.07857416
48MP0005083_abnormal_biliary_tract1.07021103
49MP0005636_abnormal_mineral_homeostasis0.99462915
50MP0003690_abnormal_glial_cell0.98494980
51MP0001765_abnormal_ion_homeostasis0.97213673
52MP0005395_other_phenotype0.95592655
53MP0005275_abnormal_skin_tensile0.95247373
54MP0003950_abnormal_plasma_membrane0.94737636
55MP0005388_respiratory_system_phenotype0.93078600
56MP0002133_abnormal_respiratory_system0.93078600
57MP0000383_abnormal_hair_follicle0.92909294
58MP0002234_abnormal_pharynx_morphology0.92818675
59MP0003646_muscle_fatigue0.92490155
60MP0002557_abnormal_social/conspecific_i0.92298137
61MP0005084_abnormal_gallbladder_morpholo0.91179158
62MP0000462_abnormal_digestive_system0.90113592
63MP0001270_distended_abdomen0.86234833
64MP0001502_abnormal_circadian_rhythm0.85796366
65MP0005647_abnormal_sex_gland0.85114568
66MP0005365_abnormal_bile_salt0.84242543
67MP0003011_delayed_dark_adaptation0.83345277
68MP0000751_myopathy0.82586176
69MP0001324_abnormal_eye_pigmentation0.82389510
70MP0009379_abnormal_foot_pigmentation0.82133025
71MP0004272_abnormal_basement_membrane0.81890014
72MP0002572_abnormal_emotion/affect_behav0.81830174
73MP0005248_abnormal_Harderian_gland0.81337457
74MP0002734_abnormal_mechanical_nocicepti0.80027995
75MP0005085_abnormal_gallbladder_physiolo0.79827119
76MP0000026_abnormal_inner_ear0.78838538
77MP0001970_abnormal_pain_threshold0.78543413
78MP0001968_abnormal_touch/_nociception0.77086708
79MP0003937_abnormal_limbs/digits/tail_de0.76883799
80MP0001727_abnormal_embryo_implantation0.76112176
81MP0002168_other_aberrant_phenotype0.75971676
82MP0001486_abnormal_startle_reflex0.75587940
83MP0005195_abnormal_posterior_eye0.74188820
84MP0008872_abnormal_physiological_respon0.73994516
85MP0003283_abnormal_digestive_organ0.73596154
86MP0000778_abnormal_nervous_system0.73133271
87MP0002098_abnormal_vibrissa_morphology0.72722623
88MP0002938_white_spotting0.72301835
89MP0009745_abnormal_behavioral_response0.70515500
90MP0000465_gastrointestinal_hemorrhage0.70320414
91MP0000534_abnormal_ureter_morphology0.70272044
92MP0005377_hearing/vestibular/ear_phenot0.69784147
93MP0003878_abnormal_ear_physiology0.69784147
94MP0002272_abnormal_nervous_system0.69270829
95MP0001851_eye_inflammation0.69148043
96MP0006292_abnormal_olfactory_placode0.68064708
97MP0005253_abnormal_eye_physiology0.67673877
98MP0002152_abnormal_brain_morphology0.67673783
99MP0004019_abnormal_vitamin_homeostasis0.67338814
100MP0002736_abnormal_nociception_after0.67042212
101MP0001963_abnormal_hearing_physiology0.66450056
102MP0006072_abnormal_retinal_apoptosis0.66037799
103MP0010678_abnormal_skin_adnexa0.65083569
104MP0004883_abnormal_blood_vessel0.64730668
105MP0001919_abnormal_reproductive_system0.63996238
106MP0000428_abnormal_craniofacial_morphol0.63764245
107MP0000955_abnormal_spinal_cord0.63751865
108MP0003633_abnormal_nervous_system0.63428122
109MP0005165_increased_susceptibility_to0.63327849
110MP0002735_abnormal_chemical_nociception0.63255416
111MP0003861_abnormal_nervous_system0.62870921
112MP0002295_abnormal_pulmonary_circulatio0.62711838
113MP0003942_abnormal_urinary_system0.62632852
114MP0003635_abnormal_synaptic_transmissio0.62582570
115MP0001299_abnormal_eye_distance/0.62133680
116MP0009643_abnormal_urine_homeostasis0.62024278
117MP0003806_abnormal_nucleotide_metabolis0.61633164
118MP0005408_hypopigmentation0.61567764
119MP0006276_abnormal_autonomic_nervous0.61382006
120MP0002064_seizures0.60773865
121MP0001944_abnormal_pancreas_morphology0.60755630
122MP0002233_abnormal_nose_morphology0.60695646
123MP0005503_abnormal_tendon_morphology0.60566219
124MP0002752_abnormal_somatic_nervous0.60454632
125MP0005167_abnormal_blood-brain_barrier0.60251895
126MP0003938_abnormal_ear_development0.57532091
127MP0005391_vision/eye_phenotype0.57373217
128MP0000049_abnormal_middle_ear0.57305811
129MP0000678_abnormal_parathyroid_gland0.56606491
130MP0003329_amyloid_beta_deposits0.56412337
131MP0000631_abnormal_neuroendocrine_gland0.56216803
132MP0009115_abnormal_fat_cell0.55722267
133MP0002229_neurodegeneration0.55700863
134MP0005164_abnormal_response_to0.55490816
135MP0001177_atelectasis0.55482975
136MP0004142_abnormal_muscle_tone0.54992278
137MP0004145_abnormal_muscle_electrophysio0.54602524
138MP0002822_catalepsy0.54429356
139MP0001958_emphysema0.53761537
140MP0008875_abnormal_xenobiotic_pharmacok0.53617603
141MP0002136_abnormal_kidney_physiology0.53255058
142MP0004859_abnormal_synaptic_plasticity0.53072783
143MP0001664_abnormal_digestion0.52549545
144MP0001293_anophthalmia0.52416828
145MP0002116_abnormal_craniofacial_bone0.52110453
146MP0003943_abnormal_hepatobiliary_system0.51968258
147MP0000467_abnormal_esophagus_morphology0.51939439
148MP0003122_maternal_imprinting0.50621080
149MP0001879_abnormal_lymphatic_vessel0.50454309
150MP0004782_abnormal_surfactant_physiolog0.50217524
151MP0009765_abnormal_xenobiotic_induced0.49566787
152MP0001188_hyperpigmentation0.49557792
153MP0005220_abnormal_exocrine_pancreas0.49314086

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.72356419
2Abnormal respiratory epithelium morphology (HP:0012253)9.72356419
3Absent/shortened dynein arms (HP:0200106)9.65136163
4Dynein arm defect of respiratory motile cilia (HP:0012255)9.65136163
5Chronic bronchitis (HP:0004469)8.12965473
6Bronchiectasis (HP:0002110)5.90390237
7Nasal polyposis (HP:0100582)5.16417594
8Abnormality of the nasal mucosa (HP:0000433)4.28342640
9Infertility (HP:0000789)4.23499067
10Bronchitis (HP:0012387)4.09942768
11Recurrent sinusitis (HP:0011108)4.01712809
12Nephronophthisis (HP:0000090)3.72626359
13Median cleft lip (HP:0000161)3.35170679
14Pancreatic fibrosis (HP:0100732)3.33421278
15Recurrent otitis media (HP:0000403)3.09413952
16Molar tooth sign on MRI (HP:0002419)2.96459727
17Abnormality of midbrain morphology (HP:0002418)2.96459727
18Abnormality of the renal medulla (HP:0100957)2.92791112
19Chronic otitis media (HP:0000389)2.92498722
20True hermaphroditism (HP:0010459)2.91974513
21Tubular atrophy (HP:0000092)2.79724280
22Tubulointerstitial nephritis (HP:0001970)2.60936055
23Chronic sinusitis (HP:0011109)2.59981915
24Medial flaring of the eyebrow (HP:0010747)2.55085395
25Congenital hepatic fibrosis (HP:0002612)2.54955642
26Supernumerary spleens (HP:0009799)2.52693663
27Facial cleft (HP:0002006)2.51925170
28Hyperactive renin-angiotensin system (HP:0000841)2.51220141
29Postaxial foot polydactyly (HP:0001830)2.38640642
30Abdominal situs inversus (HP:0003363)2.36926342
31Abnormality of abdominal situs (HP:0011620)2.36926342
32Fibular hypoplasia (HP:0003038)2.31210621
33Chronic hepatic failure (HP:0100626)2.18667427
34Tubulointerstitial abnormality (HP:0001969)2.18027146
35Pancreatic cysts (HP:0001737)2.15580534
36Abnormal biliary tract physiology (HP:0012439)2.09835797
37Bile duct proliferation (HP:0001408)2.09835797
38Gait imbalance (HP:0002141)2.07652673
39Cystic liver disease (HP:0006706)2.07021974
40Congenital primary aphakia (HP:0007707)2.03644559
41Stage 5 chronic kidney disease (HP:0003774)2.00400293
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.1308888
43Abnormal respiratory motile cilium physiology (HP:0012261)12.3411256
44Abnormal ciliary motility (HP:0012262)10.9258776
45Rhinitis (HP:0012384)10.6792559
46Furrowed tongue (HP:0000221)1.99051917
47Abnormal drinking behavior (HP:0030082)1.96564495
48Polydipsia (HP:0001959)1.96564495
49Abnormality of the renal cortex (HP:0011035)1.94450689
50Abnormality of dentin (HP:0010299)1.92807319
51Male infertility (HP:0003251)1.89947455
52Aplasia/Hypoplasia of the tongue (HP:0010295)1.87914115
53Tubulointerstitial fibrosis (HP:0005576)1.86425172
54Postaxial hand polydactyly (HP:0001162)1.84270240
55Genital tract atresia (HP:0001827)1.83917518
56Decreased circulating renin level (HP:0003351)1.82715268
57Occipital encephalocele (HP:0002085)1.81843856
58Pili torti (HP:0003777)1.77263048
59Aplasia/Hypoplasia of the spleen (HP:0010451)1.75786322
60Asplenia (HP:0001746)1.75741972
61Abnormality of the dental root (HP:0006486)1.73262862
62Taurodontia (HP:0000679)1.73262862
63Abnormality of permanent molar morphology (HP:0011071)1.73262862
64Follicular hyperkeratosis (HP:0007502)1.71841725
65Nephrogenic diabetes insipidus (HP:0009806)1.71810907
66Preaxial hand polydactyly (HP:0001177)1.67623962
67Vaginal atresia (HP:0000148)1.65602187
68Abnormality of the dental pulp (HP:0006479)1.64285958
69Abnormality of molar (HP:0011077)1.58961666
70Abnormality of molar morphology (HP:0011070)1.58961666
71Oculomotor apraxia (HP:0000657)1.58121349
72Dyschromatopsia (HP:0007641)1.57249510
73Absent frontal sinuses (HP:0002688)1.56654744
74Renal salt wasting (HP:0000127)1.56554552
75Renal dysplasia (HP:0000110)1.56467846
76Atelectasis (HP:0100750)1.53856453
77Poor coordination (HP:0002370)1.46079406
78Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.45337148
79Bifid tongue (HP:0010297)1.44972654
80Aplasia/Hypoplasia of the fibula (HP:0006492)1.44960612
81Polycystic kidney dysplasia (HP:0000113)1.44603977
8211 pairs of ribs (HP:0000878)1.42842679
83Central scotoma (HP:0000603)1.42235716
84Microglossia (HP:0000171)1.41302833
85Recurrent bronchitis (HP:0002837)1.41260965
86Hyperkalemia (HP:0002153)1.40762274
87Abnormality of renal excretion (HP:0011036)1.40009132
88Aplasia/Hypoplasia of the lens (HP:0008063)1.39936889
89Hyperaldosteronism (HP:0000859)1.38919743
90Abnormality of macular pigmentation (HP:0008002)1.37448602
91Sclerocornea (HP:0000647)1.37249468
92Male pseudohermaphroditism (HP:0000037)1.35178548
93Abnormal sex determination (HP:0012244)1.35109088
94Sex reversal (HP:0012245)1.35109088
95Bell-shaped thorax (HP:0001591)1.34612118
96Short ribs (HP:0000773)1.34132118
97Absent rod-and cone-mediated responses on ERG (HP:0007688)1.31823639
98Nephropathy (HP:0000112)1.31277528
99Abnormality of renin-angiotensin system (HP:0000847)1.31042762
100Transposition of the great arteries (HP:0001669)1.30679941
101Abnormal connection of the cardiac segments (HP:0011545)1.30679941
102Abnormal ventriculo-arterial connection (HP:0011563)1.30679941
103Ectopic anus (HP:0004397)1.30448141
104Polyuria (HP:0000103)1.28540224
105Short thorax (HP:0010306)1.28410981
106Abnormal urine output (HP:0012590)1.27774180
107Neonatal short-limb short stature (HP:0008921)1.26901843
108Anencephaly (HP:0002323)1.21856158
109Decreased central vision (HP:0007663)1.21550999
110Hypokalemic alkalosis (HP:0001949)1.20690930
111Abnormality of the frontal sinuses (HP:0002687)1.20255320
112Missing ribs (HP:0000921)1.16947628
113Narrow chest (HP:0000774)1.15774981
114Abnormality of chloride homeostasis (HP:0011422)1.15377295
115Cone-rod dystrophy (HP:0000548)1.15312074
116Nonprogressive disorder (HP:0003680)1.14285231
117Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.13549890
118Narrow forehead (HP:0000341)1.13305992
119Esophageal neoplasm (HP:0100751)1.12634608
120Neoplasm of head and neck (HP:0012288)1.12634608
121Retinitis pigmentosa (HP:0000510)1.11599462
122Bifid scrotum (HP:0000048)1.10203080
123Abnormal rod and cone electroretinograms (HP:0008323)1.07475829
124Aganglionic megacolon (HP:0002251)1.05666962
125Optic nerve coloboma (HP:0000588)1.03247458
126Prominent nasal bridge (HP:0000426)1.02922180
127Absent speech (HP:0001344)1.02912528
128Short nail (HP:0001799)1.00712090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.25414773
2PDK46.25414773
3PNCK6.19431799
4MAPK156.06951515
5PDK23.92770724
6PRKD33.71261147
7MST43.41774330
8TSSK62.99600842
9TESK12.82368535
10MAPKAPK32.22768767
11PTK2B2.06133961
12ICK2.03479319
13STK391.77409034
14WNK41.64830793
15NME11.56365265
16BCR1.43194053
17BRSK21.41556640
18TYRO31.41443188
19CASK1.40823626
20STK101.36787778
21TLK11.35975391
22WEE11.34010072
23EPHA31.21951253
24VRK11.20555608
25IRAK21.17868756
26MKNK21.16047819
27INSRR1.11419381
28GRK11.11316133
29MAP3K41.11166216
30PAK21.07119707
31ARAF1.02940860
32STK380.99883704
33FRK0.94584379
34WNK10.93915487
35MAP3K70.93755771
36NTRK20.91140780
37DAPK20.89830847
38CSK0.86096492
39MAP2K20.86025361
40IRAK10.84821677
41ERBB30.79837211
42STK38L0.77371073
43MAP4K20.77361036
44GRK70.77223226
45PAK30.77005607
46LMTK20.75674711
47EPHB10.75380130
48PIM20.74909849
49MAP3K30.72591211
50STK160.71729122
51CDK30.71616243
52SMG10.69085158
53MAPK130.68094500
54PRKCG0.67860460
55CAMKK10.62824914
56BMPR1B0.58606597
57MAPKAPK50.58482054
58LATS10.57845917
59PDK10.57698834
60ERBB20.57533064
61STK30.57484708
62MAP3K120.57078565
63OXSR10.55558311
64MYLK0.55462629
65CAMKK20.55332412
66ROCK20.54170553
67GSK3A0.53364392
68MUSK0.51423798
69LRRK20.50787442
70RPS6KA20.48810915
71MARK10.45670992
72BRAF0.45623863
73ROCK10.45335010
74SIK10.43211246
75BLK0.42662996
76MARK20.40787303
77PBK0.40262554
78MST1R0.40152636
79PRKCQ0.39416983
80ADRBK10.37913510
81STK240.37093377
82TBK10.36783525
83RIPK40.35670994
84DYRK1B0.35344813
85PRKD20.34752901
86PRKG10.34488218
87CCNB10.33461527
88EPHA40.33200705
89PRKCI0.32813155
90WNK30.32524299
91PASK0.31671264
92PRKCD0.31073613
93DYRK1A0.30798779
94AKT20.30291965
95MAP2K40.29220266
96MAP2K70.29132320
97PRKAA20.28874628
98NEK20.28397725
99MAP3K20.27825883
100AURKA0.27454629
101CAMK2A0.27265863
102FGFR20.26759749
103PRKCH0.26470748
104SGK10.26445862
105DYRK30.26371285
106PAK60.25286981
107EEF2K0.23834424
108PRKACG0.23791779
109EPHA20.23430098
110PRKACA0.23346548
111PRKCE0.23036364
112MINK10.22297031
113PAK10.22137976
114ABL10.21700150
115PRKDC0.21577144
116PDPK10.20923948
117FER0.20832357
118SRC0.19308391
119NTRK30.19276545
120NEK60.19070718
121PHKG20.18961620
122PHKG10.18961620
123TAOK10.18872212
124TIE10.18841059
125RPS6KB20.18677233
126BMPR20.18451156
127STK110.18358963
128MKNK10.17882328
129CSNK1G20.17666456
130CAMK1G0.17481935
131RPS6KA10.17293016
132PRKCZ0.17276613
133ADRBK20.16302626
134CSNK1E0.16080747
135TRPM70.15171098
136TTK0.15030687
137CAMK2G0.14944236
138GRK50.14583133
139PRKCA0.13908598
140TNIK0.13762036
141RPS6KL10.13085324
142RPS6KC10.13085324
143PRKD10.13007979
144ATM0.12949572
145MAP2K60.12288387
146MET0.12180374
147TNK20.11697818
148NLK0.10792180
149PINK10.10576238

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.29041492
2Phenylalanine metabolism_Homo sapiens_hsa003603.86260615
3Huntingtons disease_Homo sapiens_hsa050162.95452674
4Pyruvate metabolism_Homo sapiens_hsa006202.85316689
5beta-Alanine metabolism_Homo sapiens_hsa004102.84401435
6Caffeine metabolism_Homo sapiens_hsa002322.59008819
7PPAR signaling pathway_Homo sapiens_hsa033202.49770649
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.40977965
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.25101866
10Propanoate metabolism_Homo sapiens_hsa006402.25098337
11Fatty acid biosynthesis_Homo sapiens_hsa000612.15956551
12Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.04102445
13Dorso-ventral axis formation_Homo sapiens_hsa043202.03686092
14Amphetamine addiction_Homo sapiens_hsa050311.99228396
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91324100
16Linoleic acid metabolism_Homo sapiens_hsa005911.90012514
17Glucagon signaling pathway_Homo sapiens_hsa049221.88560554
18Hedgehog signaling pathway_Homo sapiens_hsa043401.78243210
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.68170670
20Ether lipid metabolism_Homo sapiens_hsa005651.67384239
21Olfactory transduction_Homo sapiens_hsa047401.64067842
22Steroid hormone biosynthesis_Homo sapiens_hsa001401.56703460
23Gastric acid secretion_Homo sapiens_hsa049711.51631746
24Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.51056467
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45867845
26Insulin secretion_Homo sapiens_hsa049111.45446193
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.45271569
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44519478
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44020730
30Mineral absorption_Homo sapiens_hsa049781.36449193
31Basal cell carcinoma_Homo sapiens_hsa052171.33572008
32Cardiac muscle contraction_Homo sapiens_hsa042601.33117291
33Estrogen signaling pathway_Homo sapiens_hsa049151.31578363
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24669189
35Renin secretion_Homo sapiens_hsa049241.23524659
36Retinol metabolism_Homo sapiens_hsa008301.20277903
37Nicotine addiction_Homo sapiens_hsa050331.18582325
38Taste transduction_Homo sapiens_hsa047421.16310295
39Pentose phosphate pathway_Homo sapiens_hsa000301.14353339
40Phototransduction_Homo sapiens_hsa047441.13820477
41Glycerolipid metabolism_Homo sapiens_hsa005611.13293281
42Calcium signaling pathway_Homo sapiens_hsa040201.11099629
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.10644610
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10334423
45Chemical carcinogenesis_Homo sapiens_hsa052041.09673912
46Histidine metabolism_Homo sapiens_hsa003401.08233229
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.05239269
48Thyroid hormone synthesis_Homo sapiens_hsa049181.04595256
49Glutathione metabolism_Homo sapiens_hsa004801.03414711
50cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02230903
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.02013612
52Oocyte meiosis_Homo sapiens_hsa041141.01743729
53Fatty acid degradation_Homo sapiens_hsa000710.99820851
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.99564570
55Circadian entrainment_Homo sapiens_hsa047130.98517473
56Arachidonic acid metabolism_Homo sapiens_hsa005900.96735825
57Salivary secretion_Homo sapiens_hsa049700.96555454
58Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95875891
59Purine metabolism_Homo sapiens_hsa002300.94679041
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.94107425
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93965168
62cAMP signaling pathway_Homo sapiens_hsa040240.89417697
63Cocaine addiction_Homo sapiens_hsa050300.89085747
64Glutamatergic synapse_Homo sapiens_hsa047240.83570566
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83146825
66Basal transcription factors_Homo sapiens_hsa030220.82268532
67Melanogenesis_Homo sapiens_hsa049160.80064274
68Butanoate metabolism_Homo sapiens_hsa006500.79232557
69Wnt signaling pathway_Homo sapiens_hsa043100.77857632
70Starch and sucrose metabolism_Homo sapiens_hsa005000.77365519
71Bile secretion_Homo sapiens_hsa049760.75784057
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.75473102
73Long-term potentiation_Homo sapiens_hsa047200.74064654
74Collecting duct acid secretion_Homo sapiens_hsa049660.72917313
75Fructose and mannose metabolism_Homo sapiens_hsa000510.72747938
76Morphine addiction_Homo sapiens_hsa050320.72452023
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.72041884
78GABAergic synapse_Homo sapiens_hsa047270.70716256
79Alzheimers disease_Homo sapiens_hsa050100.69383523
80Notch signaling pathway_Homo sapiens_hsa043300.66209303
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63668428
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62629820
83Antigen processing and presentation_Homo sapiens_hsa046120.60543702
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59869412
85Hippo signaling pathway_Homo sapiens_hsa043900.59267545
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.59009069
87Oxidative phosphorylation_Homo sapiens_hsa001900.58998417
88Dopaminergic synapse_Homo sapiens_hsa047280.55760840
89Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54551927
90Synaptic vesicle cycle_Homo sapiens_hsa047210.51932991
91Serotonergic synapse_Homo sapiens_hsa047260.51594646
92Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.51387382
93Choline metabolism in cancer_Homo sapiens_hsa052310.50699508
94Ovarian steroidogenesis_Homo sapiens_hsa049130.49916640
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49004648
96Drug metabolism - other enzymes_Homo sapiens_hsa009830.48385567
97Fatty acid metabolism_Homo sapiens_hsa012120.48076266
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47947311
99Aldosterone synthesis and secretion_Homo sapiens_hsa049250.47508872
100Circadian rhythm_Homo sapiens_hsa047100.47304250
101Regulation of autophagy_Homo sapiens_hsa041400.47118755
102Peroxisome_Homo sapiens_hsa041460.46958971
103Protein digestion and absorption_Homo sapiens_hsa049740.46956926
104Nitrogen metabolism_Homo sapiens_hsa009100.46717589
105ABC transporters_Homo sapiens_hsa020100.46042769
106Prion diseases_Homo sapiens_hsa050200.44823234
107Arginine and proline metabolism_Homo sapiens_hsa003300.41931348
108Sphingolipid metabolism_Homo sapiens_hsa006000.41600280
109Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41290580
110Tryptophan metabolism_Homo sapiens_hsa003800.40568358
111Pancreatic secretion_Homo sapiens_hsa049720.40445232
112Oxytocin signaling pathway_Homo sapiens_hsa049210.37803739
113Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.37654909
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37070759
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35416697
116AMPK signaling pathway_Homo sapiens_hsa041520.35411190
117Tyrosine metabolism_Homo sapiens_hsa003500.35154662
118Axon guidance_Homo sapiens_hsa043600.34805001
119Tight junction_Homo sapiens_hsa045300.34351713
120Alcoholism_Homo sapiens_hsa050340.33006373
121Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32772689
122Metabolic pathways_Homo sapiens_hsa011000.32028380
123Steroid biosynthesis_Homo sapiens_hsa001000.24380782
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.24230519
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24136056
126Complement and coagulation cascades_Homo sapiens_hsa046100.23329542
127Type I diabetes mellitus_Homo sapiens_hsa049400.21907583
128Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.21465339
129Hematopoietic cell lineage_Homo sapiens_hsa046400.20664010
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.20073099
131Vitamin digestion and absorption_Homo sapiens_hsa049770.19137786
132Asthma_Homo sapiens_hsa053100.18785519
133Parkinsons disease_Homo sapiens_hsa050120.18547176
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17773372

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