CFAP47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: While this gene is well-supported by transcript data, no functional information on its protein product is currently available. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axoneme assembly (GO:0035082)9.61238895
2intraciliary transport (GO:0042073)8.53949228
3cilium organization (GO:0044782)7.46386039
4cilium assembly (GO:0042384)7.32754703
5left/right axis specification (GO:0070986)6.98305771
6regulation of cilium movement (GO:0003352)6.24288147
7left/right pattern formation (GO:0060972)5.92170689
8intra-S DNA damage checkpoint (GO:0031573)5.72960519
9cellular component assembly involved in morphogenesis (GO:0010927)5.63601097
10microtubule-based movement (GO:0007018)5.59411070
11microtubule bundle formation (GO:0001578)5.50248861
12cilium morphogenesis (GO:0060271)5.31880055
13imidazole-containing compound metabolic process (GO:0052803)5.23227487
14peptidyl-lysine dimethylation (GO:0018027)5.20472896
15sperm motility (GO:0030317)5.01117627
16sperm capacitation (GO:0048240)4.84222256
17cell projection assembly (GO:0030031)4.80650660
18determination of left/right symmetry (GO:0007368)4.35023239
19microtubule depolymerization (GO:0007019)4.22725789
20determination of bilateral symmetry (GO:0009855)4.19617162
21specification of symmetry (GO:0009799)4.11372301
22retinal rod cell development (GO:0046548)4.08203632
23protein polyglutamylation (GO:0018095)3.78310167
24protein localization to cilium (GO:0061512)3.77007990
25negative regulation of JUN kinase activity (GO:0043508)3.70916061
26hepatocyte differentiation (GO:0070365)3.70202152
27centriole assembly (GO:0098534)3.69987655
28smoothened signaling pathway (GO:0007224)3.58317945
29regulation of microtubule-based movement (GO:0060632)3.56919087
30nucleoside diphosphate phosphorylation (GO:0006165)3.54026421
31folic acid-containing compound biosynthetic process (GO:0009396)3.48961937
32regulation of ARF protein signal transduction (GO:0032012)3.47878085
33microtubule severing (GO:0051013)3.43569249
34one-carbon compound transport (GO:0019755)3.30268230
35organelle assembly (GO:0070925)3.22044355
36microtubule-based process (GO:0007017)3.12500082
37histone H3-K9 demethylation (GO:0033169)3.04619688
38microtubule polymerization or depolymerization (GO:0031109)3.03690927
39photoreceptor cell maintenance (GO:0045494)3.02938465
40lateral ventricle development (GO:0021670)3.01195001
41axonemal dynein complex assembly (GO:0070286)20.8757449
42cilium or flagellum-dependent cell motility (GO:0001539)20.7516330
43retinal cone cell development (GO:0046549)2.93189721
44negative regulation of cytosolic calcium ion concentration (GO:0051481)2.91758407
45maturation of SSU-rRNA (GO:0030490)2.90311838
46regulation of centrosome duplication (GO:0010824)2.88294186
47gas transport (GO:0015669)2.87657965
48myoblast fusion (GO:0007520)2.85579861
49methionine biosynthetic process (GO:0009086)2.82797116
50gamma-aminobutyric acid transport (GO:0015812)2.77918032
51regulation of cilium assembly (GO:1902017)2.75889614
52primary alcohol catabolic process (GO:0034310)2.73885498
53positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.72771159
54cytoplasmic microtubule organization (GO:0031122)2.71210739
55lateral sprouting from an epithelium (GO:0060601)2.71009527
56regulation of autophagic vacuole assembly (GO:2000785)2.70483411
57neural tube formation (GO:0001841)2.70259449
58asymmetric protein localization (GO:0008105)2.69710013
59ethanol metabolic process (GO:0006067)2.68920528
60ribosomal small subunit assembly (GO:0000028)2.66267842
61nonmotile primary cilium assembly (GO:0035058)2.65836937
62multicellular organism reproduction (GO:0032504)2.60926351
63positive regulation of smoothened signaling pathway (GO:0045880)2.59494714
64biotin metabolic process (GO:0006768)2.59179434
65base-excision repair, AP site formation (GO:0006285)2.56758334
66histone H3-K36 demethylation (GO:0070544)2.56095252
67phosphorelay signal transduction system (GO:0000160)2.53441431
68establishment of nucleus localization (GO:0040023)2.53234337
69regulation of vacuole organization (GO:0044088)2.53124872
70methionine metabolic process (GO:0006555)2.52188151
71syncytium formation by plasma membrane fusion (GO:0000768)2.48462925
72oxygen transport (GO:0015671)2.44679846
73regulation of smoothened signaling pathway (GO:0008589)2.44655306
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.44027276
75negative regulation of inclusion body assembly (GO:0090084)2.42259950
76heart looping (GO:0001947)2.38022815
77diterpenoid biosynthetic process (GO:0016102)2.37543060
78peptidyl-lysine trimethylation (GO:0018023)2.34742711
79regulation of interleukin-5 production (GO:0032674)2.31921281
80limb development (GO:0060173)2.31751918
81appendage development (GO:0048736)2.31751918
82short-chain fatty acid metabolic process (GO:0046459)2.27794202
83vitamin transmembrane transport (GO:0035461)2.26335383
84nucleus localization (GO:0051647)2.26025765
85establishment of tissue polarity (GO:0007164)2.22386492
86establishment of planar polarity (GO:0001736)2.22386492
87reproductive system development (GO:0061458)2.21330296
88regulation of centrosome cycle (GO:0046605)2.21017970
89embryonic heart tube morphogenesis (GO:0003143)2.19256569
90negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.18222977
91tolerance induction (GO:0002507)2.17219495
92spermatid development (GO:0007286)2.15592602
93microtubule-based transport (GO:0010970)2.14339999
94interkinetic nuclear migration (GO:0022027)2.13527077
95lung epithelium development (GO:0060428)2.12768931
96cilium movement (GO:0003341)18.7294625
97epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)16.7452953
98motile cilium assembly (GO:0044458)15.2909456
99epithelial cilium movement (GO:0003351)14.6334619
100ventricular system development (GO:0021591)11.7315122

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.55722309
2ZFP322A_24550733_ChIP-Seq_MESCs_Mouse4.80014700
3PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse4.67625860
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.65285943
5GBX2_23144817_ChIP-Seq_PC3_Human4.63464975
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.45397160
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70256448
8AR_21572438_ChIP-Seq_LNCaP_Human2.55001336
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27479465
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20345473
11SMAD4_21799915_ChIP-Seq_A2780_Human2.10846599
12FUS_26573619_Chip-Seq_HEK293_Human2.04179720
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.03951085
14DROSHA_22980978_ChIP-Seq_HELA_Human1.97991602
15SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.97490248
16STAT3_23295773_ChIP-Seq_U87_Human1.94220667
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.94044468
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.91914115
19NR3C1_21868756_ChIP-Seq_MCF10A_Human1.80556385
20TCF4_23295773_ChIP-Seq_U87_Human1.76814637
21CTNNB1_20460455_ChIP-Seq_HCT116_Human1.75302670
22FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74509267
23IGF1R_20145208_ChIP-Seq_DFB_Human1.70820659
24PIAS1_25552417_ChIP-Seq_VCAP_Human1.69942526
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64476952
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60847634
27FOXM1_26456572_ChIP-Seq_MCF-7_Human1.60349889
28AHR_22903824_ChIP-Seq_MCF-7_Human1.59279209
29TP53_16413492_ChIP-PET_HCT116_Human1.57496389
30P300_19829295_ChIP-Seq_ESCs_Human1.56738191
31TOP2B_26459242_ChIP-Seq_MCF-7_Human1.55863494
32LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49613122
33ARNT_22903824_ChIP-Seq_MCF-7_Human1.48742349
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47089536
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41037166
36BCAT_22108803_ChIP-Seq_LS180_Human1.39466891
37TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38698411
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38244302
39SMAD3_21741376_ChIP-Seq_EPCs_Human1.38001201
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34556925
41TCF4_22108803_ChIP-Seq_LS180_Human1.31440956
42TAL1_26923725_Chip-Seq_HPCs_Mouse1.30960246
43TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29622845
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28788402
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28653217
46CBP_20019798_ChIP-Seq_JUKART_Human1.28653217
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28405272
48EGR1_23403033_ChIP-Seq_LIVER_Mouse1.26203724
49TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26041918
50SOX2_21211035_ChIP-Seq_LN229_Gbm1.25225115
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.24372477
52EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.23541993
53TP53_18474530_ChIP-ChIP_U2OS_Human1.21352902
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.20800250
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20615774
56VDR_22108803_ChIP-Seq_LS180_Human1.20255133
57RUNX2_22187159_ChIP-Seq_PCA_Human1.19720779
58POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19523459
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19523459
60TBL1_22424771_ChIP-Seq_293T_Human1.18894580
61PHF8_20622853_ChIP-Seq_HELA_Human1.17459261
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16420830
63PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15743578
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15729217
65CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.14237879
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13779640
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13430716
68LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12718469
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.10654001
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09102928
71NFYB_21822215_ChIP-Seq_K562_Human1.09011856
72ETV1_20927104_ChIP-Seq_GIST48_Human1.08151465
73SMRT_27268052_Chip-Seq_Bcells_Human1.07589865
74NFYA_21822215_ChIP-Seq_K562_Human1.07119035
75TP63_23658742_ChIP-Seq_EP156T_Human1.05872727
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.05342848
77PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02620947
78FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02429604
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01819344
80AR_19668381_ChIP-Seq_PC3_Human1.01351861
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01183625
82CBP_21632823_ChIP-Seq_H3396_Human1.00393865
83KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00009966
84CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99915947
85HNFA_21074721_ChIP-Seq_CACO-2_Human0.99309556
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.97828607
87E2F1_18555785_Chip-Seq_ESCs_Mouse0.97765724
88P53_22127205_ChIP-Seq_FIBROBLAST_Human0.97536188
89ERG_20517297_ChIP-Seq_VCAP_Human0.96532265
90OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96023697
91NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94001378
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92242662
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.89903900
94TAF15_26573619_Chip-Seq_HEK293_Human0.89271558
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88703416
96ZFX_18555785_Chip-Seq_ESCs_Mouse0.87203327
97LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86921728
98AR_25329375_ChIP-Seq_VCAP_Human0.86857990
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.85736110
100FOXA2_19822575_ChIP-Seq_HepG2_Human0.84597371

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology7.01722155
2MP0003879_abnormal_hair_cell4.28368356
3MP0002282_abnormal_trachea_morphology3.51485524
4MP0000569_abnormal_digit_pigmentation3.25868181
5MP0001485_abnormal_pinna_reflex3.08972176
6MP0000383_abnormal_hair_follicle2.90202435
7MP0010030_abnormal_orbit_morphology2.84852082
8MP0001984_abnormal_olfaction2.54365925
9MP0010678_abnormal_skin_adnexa2.23047026
10MP0008875_abnormal_xenobiotic_pharmacok2.22762521
11MP0004133_heterotaxia2.20627487
12MP0000566_synostosis2.15077480
13MP0002653_abnormal_ependyma_morphology10.7566248
14MP0002132_abnormal_respiratory_system1.93878227
15MP0009046_muscle_twitch1.90687558
16MP0005423_abnormal_somatic_nervous1.85437192
17MP0002249_abnormal_larynx_morphology1.74777548
18MP0003890_abnormal_embryonic-extraembry1.64838360
19MP0004043_abnormal_pH_regulation1.45232977
20MP0000026_abnormal_inner_ear1.44838370
21MP0005253_abnormal_eye_physiology1.39393024
22MP0005499_abnormal_olfactory_system1.37957644
23MP0005394_taste/olfaction_phenotype1.37957644
24MP0008789_abnormal_olfactory_epithelium1.34398896
25MP0002233_abnormal_nose_morphology1.30967786
26MP0002277_abnormal_respiratory_mucosa1.27375603
27MP0001293_anophthalmia1.26887928
28MP0001502_abnormal_circadian_rhythm1.25560890
29MP0003937_abnormal_limbs/digits/tail_de1.24770909
30MP0005171_absent_coat_pigmentation1.19095214
31MP0000049_abnormal_middle_ear1.18954046
32MP0006072_abnormal_retinal_apoptosis1.18660044
33MP0005377_hearing/vestibular/ear_phenot1.15530352
34MP0003878_abnormal_ear_physiology1.15530352
35MP0009780_abnormal_chondrocyte_physiolo1.14181465
36MP0008995_early_reproductive_senescence1.07438686
37MP0003698_abnormal_male_reproductive1.06709247
38MP0003136_yellow_coat_color1.02667272
39MP0002160_abnormal_reproductive_system1.02236372
40MP0002638_abnormal_pupillary_reflex1.01811758
41MP0005388_respiratory_system_phenotype1.01520590
42MP0002133_abnormal_respiratory_system1.01520590
43MP0005551_abnormal_eye_electrophysiolog1.00026003
44MP0001346_abnormal_lacrimal_gland0.98934841
45MP0001929_abnormal_gametogenesis0.97709327
46MP0005391_vision/eye_phenotype0.96605846
47MP0002332_abnormal_exercise_endurance0.96516321
48MP0002928_abnormal_bile_duct0.95854964
49MP0001963_abnormal_hearing_physiology0.95654250
50MP0002734_abnormal_mechanical_nocicepti0.94577907
51MP0003656_abnormal_erythrocyte_physiolo0.87682536
52MP0004019_abnormal_vitamin_homeostasis0.87211743
53MP0002084_abnormal_developmental_patter0.81342467
54MP0002116_abnormal_craniofacial_bone0.81253042
55MP0002089_abnormal_postnatal_growth/wei0.78780484
56MP0004264_abnormal_extraembryonic_tissu0.76768642
57MP0001299_abnormal_eye_distance/0.76251505
58MP0009703_decreased_birth_body0.74497765
59MP0004742_abnormal_vestibular_system0.74431474
60MP0000432_abnormal_head_morphology0.74276006
61MP0003633_abnormal_nervous_system0.73984344
62MP0005503_abnormal_tendon_morphology0.73279552
63MP0000631_abnormal_neuroendocrine_gland0.71715469
64MP0003943_abnormal_hepatobiliary_system0.71679164
65MP0002909_abnormal_adrenal_gland0.70214006
66MP0003938_abnormal_ear_development0.68587390
67MP0001486_abnormal_startle_reflex0.68559028
68MP0010368_abnormal_lymphatic_system0.68022628
69MP0001324_abnormal_eye_pigmentation0.67830185
70MP0009697_abnormal_copulation0.67673688
71MP0000427_abnormal_hair_cycle0.67441384
72MP0001756_abnormal_urination0.66334664
73MP0008961_abnormal_basal_metabolism0.66211703
74MP0010386_abnormal_urinary_bladder0.64453046
75MP0004142_abnormal_muscle_tone0.63855053
76MP0003861_abnormal_nervous_system0.63560815
77MP0002108_abnormal_muscle_morphology0.62792192
78MP0002229_neurodegeneration0.62676365
79MP0003806_abnormal_nucleotide_metabolis0.62224820
80MP0003252_abnormal_bile_duct0.62054776
81MP0000955_abnormal_spinal_cord0.61063093
82MP0005195_abnormal_posterior_eye0.59323338
83MP0003183_abnormal_peptide_metabolism0.58482746
84MP0002272_abnormal_nervous_system0.57858764
85MP0001286_abnormal_eye_development0.57211075
86MP0001970_abnormal_pain_threshold0.56793243
87MP0005167_abnormal_blood-brain_barrier0.56727511
88MP0002161_abnormal_fertility/fecundity0.55679942
89MP0004270_analgesia0.55415850
90MP0002092_abnormal_eye_morphology0.53680108
91MP0002752_abnormal_somatic_nervous0.53414005
92MP0002109_abnormal_limb_morphology0.49877734
93MP0003631_nervous_system_phenotype0.49233318
94MP0000762_abnormal_tongue_morphology0.49148476
95MP0003119_abnormal_digestive_system0.48455074
96MP0005174_abnormal_tail_pigmentation0.48414350
97MP0001270_distended_abdomen0.47597161
98MP0001348_abnormal_lacrimal_gland0.47310860
99MP0004215_abnormal_myocardial_fiber0.46566003
100MP0002168_other_aberrant_phenotype0.46555384

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)9.83356177
2Absent/shortened dynein arms (HP:0200106)9.83356177
3Rhinitis (HP:0012384)9.18307517
4Abnormal respiratory motile cilium morphology (HP:0005938)8.60103421
5Abnormal respiratory epithelium morphology (HP:0012253)8.60103421
6Chronic bronchitis (HP:0004469)7.54385997
7Nasal polyposis (HP:0100582)7.23150136
8Bronchiectasis (HP:0002110)6.63389527
9Abnormality of the nasal mucosa (HP:0000433)6.01786632
10Recurrent sinusitis (HP:0011108)5.80364725
11Occipital encephalocele (HP:0002085)5.40955396
12Chronic hepatic failure (HP:0100626)5.39424083
13Bronchitis (HP:0012387)4.73916651
14Pancreatic fibrosis (HP:0100732)4.25776865
15Recurrent otitis media (HP:0000403)4.12637749
16True hermaphroditism (HP:0010459)4.07984667
17Tubular atrophy (HP:0000092)3.78740198
18Abnormality of midbrain morphology (HP:0002418)3.51363911
19Molar tooth sign on MRI (HP:0002419)3.51363911
20Nephronophthisis (HP:0000090)3.50425350
21Pancreatic cysts (HP:0001737)3.38745198
22Abnormal biliary tract physiology (HP:0012439)3.30906009
23Bile duct proliferation (HP:0001408)3.30906009
24Cystic liver disease (HP:0006706)3.16126527
25Bell-shaped thorax (HP:0001591)2.83678104
26Recurrent bronchitis (HP:0002837)2.81093975
27Chronic sinusitis (HP:0011109)2.79669297
28Infertility (HP:0000789)2.78978667
29Polydipsia (HP:0001959)2.68361554
30Abnormal drinking behavior (HP:0030082)2.68361554
31Abnormality of the renal medulla (HP:0100957)2.66597313
32Postaxial foot polydactyly (HP:0001830)2.59337533
33Aplasia/Hypoplasia of the tongue (HP:0010295)2.56376544
34Congenital hepatic fibrosis (HP:0002612)2.39337835
35Atelectasis (HP:0100750)2.37476285
36Tubulointerstitial nephritis (HP:0001970)2.36549274
37Anencephaly (HP:0002323)2.23425348
38Medial flaring of the eyebrow (HP:0010747)2.18332578
39Abnormality of the renal cortex (HP:0011035)2.15545582
40Oculomotor apraxia (HP:0000657)2.09059274
41Sclerocornea (HP:0000647)2.07436308
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)14.6505593
43Abnormal ciliary motility (HP:0012262)10.7449859
44Abnormal respiratory motile cilium physiology (HP:0012261)10.7350511
45Chronic otitis media (HP:0000389)1.99639209
46Congenital primary aphakia (HP:0007707)1.99005949
47Gait imbalance (HP:0002141)1.96376386
48Furrowed tongue (HP:0000221)1.95044036
49Male pseudohermaphroditism (HP:0000037)1.90993451
50Intellectual disability, moderate (HP:0002342)1.87845792
51Postaxial hand polydactyly (HP:0001162)1.82899463
52Nephrogenic diabetes insipidus (HP:0009806)1.76264542
53Male infertility (HP:0003251)1.72522518
54Anophthalmia (HP:0000528)1.71926882
55Preaxial hand polydactyly (HP:0001177)1.71740867
56Stage 5 chronic kidney disease (HP:0003774)1.71217963
57Optic nerve coloboma (HP:0000588)1.68793038
58Polyuria (HP:0000103)1.67578924
59Median cleft lip (HP:0000161)1.66472888
60Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65103935
61Genital tract atresia (HP:0001827)1.58277730
62Poor coordination (HP:0002370)1.54468291
63Portal hypertension (HP:0001409)1.52503705
64Narrow forehead (HP:0000341)1.52012068
65Abnormality of the fingertips (HP:0001211)1.50525747
66IgM deficiency (HP:0002850)1.50004419
67Vaginal atresia (HP:0000148)1.49395319
68Abnormal urine output (HP:0012590)1.47346868
69Nephropathy (HP:0000112)1.43219055
70Abnormality of renal excretion (HP:0011036)1.39278293
71Abnormality of the hepatic vasculature (HP:0006707)1.38791138
72Autoimmune hemolytic anemia (HP:0001890)1.36546811
73Tubulointerstitial abnormality (HP:0001969)1.35719643
74Prominent nasal bridge (HP:0000426)1.29020853
75Bifid tongue (HP:0010297)1.24692695
76Abnormal rod and cone electroretinograms (HP:0008323)1.23746935
77Colitis (HP:0002583)1.22204731
78Highly arched eyebrow (HP:0002553)1.21665807
79Hyperactive renin-angiotensin system (HP:0000841)1.21238685
80Supernumerary spleens (HP:0009799)1.16549225
81Aganglionic megacolon (HP:0002251)1.14354929
82Taurodontia (HP:0000679)1.07526241
83Abnormality of permanent molar morphology (HP:0011071)1.07526241
84Abnormality of the dental root (HP:0006486)1.07526241
85Facial cleft (HP:0002006)1.06061481
86Long face (HP:0000276)1.04594771
87Genetic anticipation (HP:0003743)1.03237342
88Hyperglycinemia (HP:0002154)1.02518015
89Cutaneous finger syndactyly (HP:0010554)1.01916694
90Renal dysplasia (HP:0000110)1.00459384
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)0.98911756
92Ectopic anus (HP:0004397)0.98364900
93Abnormality of molar (HP:0011077)0.98002098
94Abnormality of molar morphology (HP:0011070)0.98002098
95Abnormality of the dental pulp (HP:0006479)0.97453788
96Fibular hypoplasia (HP:0003038)0.96969011
97Multicystic kidney dysplasia (HP:0000003)0.96310565
98Chorioretinal coloboma (HP:0000567)0.94082295
99Asthma (HP:0002099)0.93579476
100Retinitis pigmentosa (HP:0000510)0.92152415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PTK2B3.83701024
2MST42.89580318
3MET2.72890784
4PINK12.63092831
5TLK12.20090214
6PNCK2.05594218
7MAPK1510.7921241
8MAP3K41.75135733
9MAP2K71.71073238
10FGFR21.70735092
11LATS11.69948423
12STK31.44494559
13BMX1.39297490
14FGR1.38974172
15ZAK1.38459072
16FRK1.34426638
17STK161.33529548
18EPHA21.32931288
19BRSK21.32171239
20MUSK1.28246211
21SGK21.27738143
22BCKDK1.23736048
23STK391.22949656
24RET1.19051669
25BCR1.15107784
26RPS6KA51.14699407
27SGK2231.08538193
28SGK4941.08538193
29MAP3K121.07221068
30NTRK21.00297212
31STK38L0.99596257
32CSF1R0.99561480
33CAMK40.98309034
34WNK40.96805035
35CSK0.96512172
36MAP3K20.95948355
37CDK120.89168665
38NEK60.83300659
39ERBB20.81231779
40MAP2K40.80025829
41DYRK30.74167693
42SGK30.72753336
43NLK0.70806761
44MYLK0.65289172
45NEK90.61922747
46BMPR1B0.60665002
47PDGFRB0.59238453
48TRPM70.59221989
49CDK30.57601055
50PRKCI0.56789123
51LRRK20.56600492
52MAPK130.55497024
53CSNK1G10.54848214
54STK240.52583036
55SGK10.51992034
56MAP3K130.51881261
57CSNK1A1L0.49923271
58ROCK10.48822436
59TSSK60.48485213
60PRKD30.47237454
61WEE10.47008807
62AKT20.45828029
63STK380.44695819
64MAPK100.44178306
65IRAK10.43149925
66MARK30.41664721
67TTK0.41534020
68VRK10.40684349
69MAPKAPK30.40031203
70STK40.39956350
71MARK20.39260585
72WNK30.38140995
73FER0.37648147
74CDK80.37610247
75MAPK70.37585151
76CAMK1G0.37441116
77EPHA40.36480239
78PRKCQ0.35633252
79GRK10.34805748
80RPS6KB20.34085551
81EGFR0.32951548
82NEK20.32779128
83PRKAA10.31814493
84CDK50.30771324
85PLK10.29876253
86TIE10.29681086
87AURKA0.29335543
88STK110.28595365
89MAP3K70.28492705
90ARAF0.28155580
91CAMKK20.27818292
92CDK90.27177842
93CAMK2G0.27169569
94CASK0.26318087
95MST1R0.25761343
96RPS6KA30.25653587
97CAMK2A0.24841147
98FGFR30.24551094
99OBSCN0.20571009
100CAMKK10.20568413

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.92494242
2Huntingtons disease_Homo sapiens_hsa050163.82999230
3Alcoholism_Homo sapiens_hsa050343.59846443
4Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.44255609
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.35031447
6Chemical carcinogenesis_Homo sapiens_hsa052042.94004375
7One carbon pool by folate_Homo sapiens_hsa006702.85069620
8Histidine metabolism_Homo sapiens_hsa003402.41831999
9Nicotine addiction_Homo sapiens_hsa050332.38777886
10Hedgehog signaling pathway_Homo sapiens_hsa043402.31858680
11ABC transporters_Homo sapiens_hsa020102.28373300
12Phenylalanine metabolism_Homo sapiens_hsa003602.07379918
13Propanoate metabolism_Homo sapiens_hsa006401.93231286
14Dorso-ventral axis formation_Homo sapiens_hsa043201.88662187
15Tyrosine metabolism_Homo sapiens_hsa003501.76264150
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71404171
17Primary bile acid biosynthesis_Homo sapiens_hsa001201.65809351
18Basal cell carcinoma_Homo sapiens_hsa052171.63103024
19Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.59188334
20beta-Alanine metabolism_Homo sapiens_hsa004101.52428292
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49978221
22Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48201656
23Viral carcinogenesis_Homo sapiens_hsa052031.42050567
24Retinol metabolism_Homo sapiens_hsa008301.41952674
25Circadian rhythm_Homo sapiens_hsa047101.41281976
26Glutathione metabolism_Homo sapiens_hsa004801.36690566
27Caffeine metabolism_Homo sapiens_hsa002321.29474805
28Salivary secretion_Homo sapiens_hsa049701.25584363
29Peroxisome_Homo sapiens_hsa041461.24942490
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.24781427
31Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21819283
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19551046
33Linoleic acid metabolism_Homo sapiens_hsa005911.07198705
34GABAergic synapse_Homo sapiens_hsa047271.02968792
35Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02061066
36Olfactory transduction_Homo sapiens_hsa047401.00240366
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99967931
38Hippo signaling pathway_Homo sapiens_hsa043900.88863615
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.88255738
40Taste transduction_Homo sapiens_hsa047420.86863436
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85741420
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85544881
43Bile secretion_Homo sapiens_hsa049760.83854493
44Nitrogen metabolism_Homo sapiens_hsa009100.83854000
45Sphingolipid metabolism_Homo sapiens_hsa006000.78002238
46Gap junction_Homo sapiens_hsa045400.76539680
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74336832
48Tight junction_Homo sapiens_hsa045300.74212658
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68623068
50cAMP signaling pathway_Homo sapiens_hsa040240.67582188
51Oxidative phosphorylation_Homo sapiens_hsa001900.66323767
52Calcium signaling pathway_Homo sapiens_hsa040200.64713112
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62643087
54Cardiac muscle contraction_Homo sapiens_hsa042600.60827800
55Alzheimers disease_Homo sapiens_hsa050100.58856174
56Regulation of autophagy_Homo sapiens_hsa041400.54811871
57Wnt signaling pathway_Homo sapiens_hsa043100.52431593
58Arachidonic acid metabolism_Homo sapiens_hsa005900.52283184
59Choline metabolism in cancer_Homo sapiens_hsa052310.51615869
60Melanogenesis_Homo sapiens_hsa049160.51602952
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.51109151
62TGF-beta signaling pathway_Homo sapiens_hsa043500.50664149
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50087668
64Tryptophan metabolism_Homo sapiens_hsa003800.49070627
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48647891
66Fatty acid degradation_Homo sapiens_hsa000710.48268457
67Morphine addiction_Homo sapiens_hsa050320.48178298
68Starch and sucrose metabolism_Homo sapiens_hsa005000.47278529
69Circadian entrainment_Homo sapiens_hsa047130.44088101
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43975291
71N-Glycan biosynthesis_Homo sapiens_hsa005100.43943372
72ErbB signaling pathway_Homo sapiens_hsa040120.43711172
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41705182
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.39328814
75Metabolic pathways_Homo sapiens_hsa011000.37886433
76Renin secretion_Homo sapiens_hsa049240.36606767
77Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35997343
78Gastric acid secretion_Homo sapiens_hsa049710.35654736
79Folate biosynthesis_Homo sapiens_hsa007900.33757486
80Basal transcription factors_Homo sapiens_hsa030220.33368124
81Complement and coagulation cascades_Homo sapiens_hsa046100.32665736
82Oxytocin signaling pathway_Homo sapiens_hsa049210.31831808
83Purine metabolism_Homo sapiens_hsa002300.31170018
84Pancreatic secretion_Homo sapiens_hsa049720.30955583
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30029358
86Notch signaling pathway_Homo sapiens_hsa043300.28073115
87Adherens junction_Homo sapiens_hsa045200.27307020
88Parkinsons disease_Homo sapiens_hsa050120.26146355
89Ovarian steroidogenesis_Homo sapiens_hsa049130.24473483
90Butanoate metabolism_Homo sapiens_hsa006500.23954745
91Inositol phosphate metabolism_Homo sapiens_hsa005620.23189414
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23181344
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.22947787
94Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.22132731
95Axon guidance_Homo sapiens_hsa043600.20338964
96Fanconi anemia pathway_Homo sapiens_hsa034600.19817852
97PPAR signaling pathway_Homo sapiens_hsa033200.18551763
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18401048
99Proteoglycans in cancer_Homo sapiens_hsa052050.16560247
100Glutamatergic synapse_Homo sapiens_hsa047240.16427979

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