CETN4P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.27096780
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.10592975
3protein neddylation (GO:0045116)4.59000307
4positive regulation of mitochondrial fission (GO:0090141)4.58813163
5cullin deneddylation (GO:0010388)4.52276140
6positive regulation of megakaryocyte differentiation (GO:0045654)4.35408474
7negative regulation of thymocyte apoptotic process (GO:0070244)4.26781271
8positive regulation of cAMP-mediated signaling (GO:0043950)4.25139346
9protein localization to cilium (GO:0061512)4.12414637
10response to pheromone (GO:0019236)4.05200009
11negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)4.01755178
12negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.90047668
13positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.83676554
14peroxisome fission (GO:0016559)3.81419368
15protein deneddylation (GO:0000338)3.81285776
16behavioral response to ethanol (GO:0048149)3.78620179
17fatty acid elongation (GO:0030497)3.74123135
18regulation of megakaryocyte differentiation (GO:0045652)3.71489857
19cytidine metabolic process (GO:0046087)3.62016795
20cytidine catabolic process (GO:0006216)3.62016795
21cytidine deamination (GO:0009972)3.62016795
22regulation of mitochondrial fission (GO:0090140)3.61916858
23purinergic nucleotide receptor signaling pathway (GO:0035590)3.58736289
24regulation of hematopoietic progenitor cell differentiation (GO:1901532)3.57360699
25protein-cofactor linkage (GO:0018065)3.53329460
26thrombin receptor signaling pathway (GO:0070493)3.53117706
27negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.52390506
28regulation of cilium movement (GO:0003352)3.31512360
29snRNA metabolic process (GO:0016073)3.29245709
30intraciliary transport (GO:0042073)3.28595052
31snRNA processing (GO:0016180)3.27555252
32pyrimidine ribonucleoside catabolic process (GO:0046133)3.23019776
33S-adenosylmethionine metabolic process (GO:0046500)3.20956076
34regulation of oxidative stress-induced neuron death (GO:1903203)3.20000350
35neuronal action potential propagation (GO:0019227)3.18659324
36mitotic cell cycle arrest (GO:0071850)3.14576895
37protein K6-linked ubiquitination (GO:0085020)3.14363860
38neuron fate determination (GO:0048664)3.12176286
39negative regulation of heart rate (GO:0010459)3.10483541
40fucose catabolic process (GO:0019317)3.09661674
41L-fucose metabolic process (GO:0042354)3.09661674
42L-fucose catabolic process (GO:0042355)3.09661674
43long-chain fatty acid biosynthetic process (GO:0042759)3.09111374
44positive regulation of toll-like receptor signaling pathway (GO:0034123)3.03273866
45negative regulation of response to food (GO:0032096)3.02493903
46negative regulation of appetite (GO:0032099)3.02493903
47positive regulation of erythrocyte differentiation (GO:0045648)3.00147727
48axonemal dynein complex assembly (GO:0070286)2.97290205
49mitochondrial respiratory chain complex I assembly (GO:0032981)2.94822306
50NADH dehydrogenase complex assembly (GO:0010257)2.94822306
51mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94822306
52positive regulation of glycolytic process (GO:0045821)2.94053963
53aggressive behavior (GO:0002118)2.92293224
54lactate metabolic process (GO:0006089)2.92189601
55triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.87800796
56epithelial cilium movement (GO:0003351)2.85418498
57heme transport (GO:0015886)2.84483178
58cellular response to interferon-beta (GO:0035458)2.83981868
59cilium or flagellum-dependent cell motility (GO:0001539)2.81089354
60behavioral response to nicotine (GO:0035095)2.79422857
61cellular ketone body metabolic process (GO:0046950)2.76876049
62platelet dense granule organization (GO:0060155)2.75954147
63GMP metabolic process (GO:0046037)2.74788585
64negative regulation of digestive system process (GO:0060457)2.74444157
65regulation of mesenchymal cell apoptotic process (GO:2001053)2.73508200
66negative regulation of membrane potential (GO:0045837)2.73375733
67regulation of Golgi to plasma membrane protein transport (GO:0042996)2.72992257
68regulation of cAMP-dependent protein kinase activity (GO:2000479)2.71036007
69L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67848759
70positive regulation of prostaglandin secretion (GO:0032308)2.67389147
71negative regulation of nitric-oxide synthase activity (GO:0051001)2.66809266
72piRNA metabolic process (GO:0034587)2.63261414
73mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.61619704
74neuronal action potential (GO:0019228)2.61570597
75positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.57180513
76terpenoid biosynthetic process (GO:0016114)2.57079598
77estrogen biosynthetic process (GO:0006703)2.56515590
78lipoxygenase pathway (GO:0019372)2.54507697
79negative regulation of transcription regulatory region DNA binding (GO:2000678)2.54349301
80mitochondrial fission (GO:0000266)2.53732655
81purinergic receptor signaling pathway (GO:0035587)2.53003291
82pyrimidine nucleoside catabolic process (GO:0046135)2.50479930
83sleep (GO:0030431)2.49423600
84glucosamine-containing compound catabolic process (GO:1901072)2.48580432
85single strand break repair (GO:0000012)2.47830670
86ketone body metabolic process (GO:1902224)2.46497690
87response to xenobiotic stimulus (GO:0009410)2.46427981
88relaxation of smooth muscle (GO:0044557)2.45935506
89regulation of thymocyte apoptotic process (GO:0070243)2.42554995
90mitochondrion morphogenesis (GO:0070584)2.41179801
91regulation of female receptivity (GO:0045924)2.40846968
92positive regulation of endothelial cell differentiation (GO:0045603)2.38863018
93CDP-diacylglycerol biosynthetic process (GO:0016024)2.38417339
94regulation of cholesterol efflux (GO:0010874)2.38274229
95amino acid salvage (GO:0043102)2.38080822
96L-methionine salvage (GO:0071267)2.38080822
97L-methionine biosynthetic process (GO:0071265)2.38080822
98Arp2/3 complex-mediated actin nucleation (GO:0034314)2.37910740
99regulation of T-helper 1 cell differentiation (GO:0045625)2.37818453
100positive regulation of protein homodimerization activity (GO:0090073)2.37434934

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IGF1R_20145208_ChIP-Seq_DFB_Human4.19770904
2VDR_22108803_ChIP-Seq_LS180_Human4.17233026
3ZNF274_21170338_ChIP-Seq_K562_Hela3.78702531
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.70197825
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79787049
6FUS_26573619_Chip-Seq_HEK293_Human2.78051563
7TAF15_26573619_Chip-Seq_HEK293_Human2.70716377
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.64644927
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.59911648
10GBX2_23144817_ChIP-Seq_PC3_Human2.47838608
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39902132
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.34787465
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.22192491
14PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.11527456
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.11461640
16SRF_21415370_ChIP-Seq_HL-1_Mouse1.91184808
17EWS_26573619_Chip-Seq_HEK293_Human1.89268683
18GABP_17652178_ChIP-ChIP_JURKAT_Human1.81631052
19CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79649243
20IRF1_19129219_ChIP-ChIP_H3396_Human1.79269233
21TP53_22573176_ChIP-Seq_HFKS_Human1.77150142
22E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75745330
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69394219
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65932620
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61751840
26GATA3_21878914_ChIP-Seq_MCF-7_Human1.60895599
27VDR_23849224_ChIP-Seq_CD4+_Human1.60241231
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58045721
29MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56572236
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.52924598
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.51714118
32NANOG_19829295_ChIP-Seq_ESCs_Human1.51234554
33SOX2_19829295_ChIP-Seq_ESCs_Human1.51234554
34KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50487443
35SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.50027574
36AUTS2_25519132_ChIP-Seq_293T-REX_Human1.49869082
37AR_25329375_ChIP-Seq_VCAP_Human1.47808164
38P300_19829295_ChIP-Seq_ESCs_Human1.47796415
39ER_23166858_ChIP-Seq_MCF-7_Human1.47315357
40* AR_20517297_ChIP-Seq_VCAP_Human1.43377174
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40245692
42ELK1_19687146_ChIP-ChIP_HELA_Human1.39596570
43SALL4_22934838_ChIP-ChIP_CD34+_Human1.39386781
44JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.39367655
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.37629968
46PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36205040
47PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32237665
48FOXP3_21729870_ChIP-Seq_TREG_Human1.31474197
49RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30085978
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.29526109
51HOXB7_26014856_ChIP-Seq_BT474_Human1.29334351
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28006464
53CBP_20019798_ChIP-Seq_JUKART_Human1.28006464
54NCOR_22424771_ChIP-Seq_293T_Human1.24633843
55NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.24131435
56* CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.22942064
57STAT3_23295773_ChIP-Seq_U87_Human1.21723851
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21155833
59SMAD4_21799915_ChIP-Seq_A2780_Human1.18500705
60* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.17306445
61IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.15668442
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15337722
63HTT_18923047_ChIP-ChIP_STHdh_Human1.14918015
64HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13586130
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.13266980
66FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13266980
67TCF4_23295773_ChIP-Seq_U87_Human1.12766736
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12107711
69CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.11335352
70GATA3_26560356_Chip-Seq_TH2_Human1.09767662
71FOXH1_21741376_ChIP-Seq_EPCs_Human1.07906410
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.07599737
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07004912
74TAL1_26923725_Chip-Seq_HPCs_Mouse1.06429205
75RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05523598
76KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04604743
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02834718
78MYC_19829295_ChIP-Seq_ESCs_Human1.02509771
79ETV2_25802403_ChIP-Seq_MESCs_Mouse1.00968988
80ETV1_20927104_ChIP-Seq_GIST48_Human1.00207117
81STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98466558
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98143778
83PHF8_20622853_ChIP-Seq_HELA_Human0.97503486
84EZH2_27294783_Chip-Seq_NPCs_Mouse0.97058759
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.96786057
86NOTCH1_21737748_ChIP-Seq_TLL_Human0.96056334
87EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95890293
88NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94944960
89OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94272188
90P53_22387025_ChIP-Seq_ESCs_Mouse0.93651122
91GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.92850703
92RBPJ_21746931_ChIP-Seq_IB4_Human0.92721527
93RNF2_27304074_Chip-Seq_NSC_Mouse0.92657668
94MYC_18940864_ChIP-ChIP_HL60_Human0.92639393
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.92620936
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91359437
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.90971507
98JUN_21703547_ChIP-Seq_K562_Human0.90823784
99ETS1_20019798_ChIP-Seq_JURKAT_Human0.90436108
100ERG_20517297_ChIP-Seq_VCAP_Human0.90430046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland4.18185037
2MP0005187_abnormal_penis_morphology3.20115590
3MP0005464_abnormal_platelet_physiology3.02351728
4MP0008877_abnormal_DNA_methylation2.81774944
5MP0003045_fibrosis2.52292409
6MP0008995_early_reproductive_senescence2.41772018
7MP0009697_abnormal_copulation2.25749080
8MP0003136_yellow_coat_color2.25061549
9MP0001984_abnormal_olfaction2.19686099
10MP0002736_abnormal_nociception_after2.17365825
11MP0004215_abnormal_myocardial_fiber2.08978926
12MP0008872_abnormal_physiological_respon2.08646873
13MP0004133_heterotaxia2.06644881
14MP0003011_delayed_dark_adaptation2.06401737
15MP0002139_abnormal_hepatobiliary_system2.04690142
16MP0006292_abnormal_olfactory_placode1.99338053
17MP0006072_abnormal_retinal_apoptosis1.96591870
18MP0003828_pulmonary_edema1.96304035
19MP0005365_abnormal_bile_salt1.90995432
20MP0002272_abnormal_nervous_system1.84286612
21MP0009046_muscle_twitch1.80957843
22MP0000013_abnormal_adipose_tissue1.79791166
23MP0003724_increased_susceptibility_to1.78484374
24MP0005084_abnormal_gallbladder_morpholo1.75171468
25MP0005410_abnormal_fertilization1.74855852
26MP0006035_abnormal_mitochondrial_morpho1.74245000
27MP0001968_abnormal_touch/_nociception1.74148852
28MP0002638_abnormal_pupillary_reflex1.71716607
29MP0004084_abnormal_cardiac_muscle1.70292572
30MP0008789_abnormal_olfactory_epithelium1.68778244
31MP0008775_abnormal_heart_ventricle1.68403972
32MP0000230_abnormal_systemic_arterial1.63101422
33MP0006276_abnormal_autonomic_nervous1.62431603
34MP0005253_abnormal_eye_physiology1.62196116
35MP0004885_abnormal_endolymph1.60342112
36MP0005167_abnormal_blood-brain_barrier1.53935701
37MP0008004_abnormal_stomach_pH1.53041735
38MP0006036_abnormal_mitochondrial_physio1.52630534
39MP0000372_irregular_coat_pigmentation1.51524578
40MP0003880_abnormal_central_pattern1.51053731
41MP0005499_abnormal_olfactory_system1.50475586
42MP0005394_taste/olfaction_phenotype1.50475586
43MP0005671_abnormal_response_to1.47824956
44MP0001501_abnormal_sleep_pattern1.44003540
45MP0009780_abnormal_chondrocyte_physiolo1.42875009
46MP0000647_abnormal_sebaceous_gland1.40461771
47MP0003879_abnormal_hair_cell1.37782335
48MP0001764_abnormal_homeostasis1.37618325
49MP0005647_abnormal_sex_gland1.33973306
50MP0005551_abnormal_eye_electrophysiolog1.33671303
51MP0002822_catalepsy1.30711760
52MP0010329_abnormal_lipoprotein_level1.30643316
53MP0003786_premature_aging1.27168164
54MP0004036_abnormal_muscle_relaxation1.26926436
55MP0003806_abnormal_nucleotide_metabolis1.26723645
56MP0002282_abnormal_trachea_morphology1.25606153
57MP0002234_abnormal_pharynx_morphology1.23755357
58MP0009764_decreased_sensitivity_to1.23549856
59MP0005083_abnormal_biliary_tract1.22566918
60MP0002735_abnormal_chemical_nociception1.17617814
61MP0000678_abnormal_parathyroid_gland1.17313936
62MP0000465_gastrointestinal_hemorrhage1.16460243
63MP0000631_abnormal_neuroendocrine_gland1.15886895
64MP0002090_abnormal_vision1.10749068
65MP0001486_abnormal_startle_reflex1.04974723
66MP0005174_abnormal_tail_pigmentation1.04871670
67MP0001502_abnormal_circadian_rhythm1.04740649
68MP0002254_reproductive_system_inflammat1.04382914
69MP0008875_abnormal_xenobiotic_pharmacok1.03589298
70MP0002148_abnormal_hypersensitivity_rea1.02172041
71MP0005535_abnormal_body_temperature1.02099442
72MP0009745_abnormal_behavioral_response1.01906950
73MP0000343_altered_response_to1.00559179
74MP0004142_abnormal_muscle_tone0.99268453
75MP0003186_abnormal_redox_activity0.96956826
76MP0002132_abnormal_respiratory_system0.96624221
77MP0001986_abnormal_taste_sensitivity0.95333949
78MP0003252_abnormal_bile_duct0.91861597
79MP0002067_abnormal_sensory_capabilities0.91056481
80MP0002557_abnormal_social/conspecific_i0.87256450
81MP0002733_abnormal_thermal_nociception0.86635344
82MP0001545_abnormal_hematopoietic_system0.84911129
83MP0005397_hematopoietic_system_phenotyp0.84911129
84MP0009763_increased_sensitivity_to0.83196777
85MP0001873_stomach_inflammation0.82787591
86MP0005085_abnormal_gallbladder_physiolo0.82057272
87MP0001663_abnormal_digestive_system0.80803417
88MP0010368_abnormal_lymphatic_system0.80691056
89MP0003698_abnormal_male_reproductive0.79506585
90MP0004782_abnormal_surfactant_physiolog0.79057942
91MP0005000_abnormal_immune_tolerance0.77730949
92MP0001970_abnormal_pain_threshold0.77143363
93MP0004043_abnormal_pH_regulation0.75185529
94MP0005332_abnormal_amino_acid0.75138498
95MP0008058_abnormal_DNA_repair0.74762655
96MP0005645_abnormal_hypothalamus_physiol0.70283334
97MP0003866_abnormal_defecation0.70145939
98MP0003938_abnormal_ear_development0.69972215
99MP0000015_abnormal_ear_pigmentation0.69272472
100MP0001963_abnormal_hearing_physiology0.69110276

Predicted human phenotypes

RankGene SetZ-score
1Atonic seizures (HP:0010819)4.16096449
2Fibular aplasia (HP:0002990)3.92329881
3Dyschromatopsia (HP:0007641)3.67646466
4Short tibia (HP:0005736)3.67615693
5Hypochromic microcytic anemia (HP:0004840)3.43258952
63-Methylglutaconic aciduria (HP:0003535)3.40600342
7Prolonged bleeding time (HP:0003010)3.32880229
8Aplasia/Hypoplasia of the tibia (HP:0005772)3.32262136
9Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.30988401
10Abnormality of alanine metabolism (HP:0010916)3.30988401
11Hyperalaninemia (HP:0003348)3.30988401
12Petechiae (HP:0000967)3.21962161
13Polydipsia (HP:0001959)3.21407386
14Abnormal drinking behavior (HP:0030082)3.21407386
15Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.13935342
16Short 1st metacarpal (HP:0010034)3.13935342
17Hyperlipoproteinemia (HP:0010980)3.10420178
18Acute necrotizing encephalopathy (HP:0006965)3.09189983
19Nephronophthisis (HP:0000090)3.07295346
20Progressive inability to walk (HP:0002505)3.06739535
21Dynein arm defect of respiratory motile cilia (HP:0012255)3.06378292
22Absent/shortened dynein arms (HP:0200106)3.06378292
23Abnormal auditory evoked potentials (HP:0006958)2.98928376
24Abnormality of the renal cortex (HP:0011035)2.93476645
25Acute encephalopathy (HP:0006846)2.80349442
26Tubular atrophy (HP:0000092)2.79883475
27Congenital malformation of the right heart (HP:0011723)2.73068764
28Double outlet right ventricle (HP:0001719)2.73068764
29Abnormality of the 1st metacarpal (HP:0010009)2.72313725
30Supernumerary spleens (HP:0009799)2.69600555
31Abnormal mitochondria in muscle tissue (HP:0008316)2.68758601
32True hermaphroditism (HP:0010459)2.63093970
33Pancreatic cysts (HP:0001737)2.62150926
34Abnormal ciliary motility (HP:0012262)2.61003835
35Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.60671596
36Abnormality of the renal medulla (HP:0100957)2.60148095
37Abnormality of the proximal phalanges of the hand (HP:0009834)2.58954330
38Progressive macrocephaly (HP:0004481)2.56602050
39Absence seizures (HP:0002121)2.55912966
40Abnormality of the anterior horn cell (HP:0006802)2.55152016
41Degeneration of anterior horn cells (HP:0002398)2.55152016
42Polyuria (HP:0000103)2.49220837
43Aplasia/Hypoplasia of the fibula (HP:0006492)2.48149021
44Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.47775255
45Severe visual impairment (HP:0001141)2.47728461
46Abnormal respiratory epithelium morphology (HP:0012253)2.47147233
47Abnormal respiratory motile cilium morphology (HP:0005938)2.47147233
48Insidious onset (HP:0003587)2.46593573
49Termporal pattern (HP:0011008)2.46593573
50Menorrhagia (HP:0000132)2.40435505
51Increased mean platelet volume (HP:0011877)2.35739590
52Febrile seizures (HP:0002373)2.34040021
53Aplasia/Hypoplasia of the spleen (HP:0010451)2.29462290
54Dialeptic seizures (HP:0011146)2.28337098
55Mitochondrial inheritance (HP:0001427)2.24380803
56Recurrent corneal erosions (HP:0000495)2.24083908
57Poikilocytosis (HP:0004447)2.19385931
58Abnormality of the phalanges of the 5th finger (HP:0004213)2.18326905
59Aplasia/hypoplasia of the humerus (HP:0006507)2.17794237
60Stomatitis (HP:0010280)2.16181613
61Abnormality of the middle phalanges of the toes (HP:0010183)2.12308819
62Asplenia (HP:0001746)2.09432839
63Abnormal platelet volume (HP:0011876)2.08194998
64Fibular hypoplasia (HP:0003038)2.07715914
65Chronic hepatic failure (HP:0100626)2.07456672
66Episodic fever (HP:0001954)2.06477382
67Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.05837536
68Degeneration of the lateral corticospinal tracts (HP:0002314)2.05837536
69Pancreatic fibrosis (HP:0100732)2.02259865
70Increased CSF lactate (HP:0002490)2.00075878
71Central scotoma (HP:0000603)1.98376983
72Acanthocytosis (HP:0001927)1.97722012
73Abnormal urine output (HP:0012590)1.97398722
74Abnormality of the costochondral junction (HP:0000919)1.93546163
75Dyskinesia (HP:0100660)1.92417184
76Anencephaly (HP:0002323)1.91863341
77Focal motor seizures (HP:0011153)1.91245610
78Inability to walk (HP:0002540)1.89415267
79Abnormal platelet function (HP:0011869)1.87813851
80Impaired platelet aggregation (HP:0003540)1.87813851
81Arthropathy (HP:0003040)1.87316075
82Severe muscular hypotonia (HP:0006829)1.85510217
83Upper limb muscle weakness (HP:0003484)1.82195152
84Molar tooth sign on MRI (HP:0002419)1.81654512
85Abnormality of midbrain morphology (HP:0002418)1.81654512
86Abnormal respiratory motile cilium physiology (HP:0012261)1.81641534
87Short humerus (HP:0005792)1.80441383
88Postaxial foot polydactyly (HP:0001830)1.80302387
89Intention tremor (HP:0002080)1.78364514
90Disproportionate short-trunk short stature (HP:0003521)1.76311276
91Cerebral edema (HP:0002181)1.75601732
92Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.73762884
93Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.73282659
94Short hallux (HP:0010109)1.71764049
95Tongue fasciculations (HP:0001308)1.71585042
96Short phalanx of the thumb (HP:0009660)1.70834433
97Medial flaring of the eyebrow (HP:0010747)1.70344967
98Abnormal finger flexion creases (HP:0006143)1.69548268
99Renal Fanconi syndrome (HP:0001994)1.69309439
100Aplasia/Hypoplasia of the hallux (HP:0008362)1.66592448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.84044429
2WNK43.84971066
3EPHA33.31655922
4STK393.03310038
5PLK22.58368514
6TRIM282.57352112
7MAP4K22.52310279
8TAOK32.41669726
9SCYL22.40448933
10PRKD32.24083848
11NUAK11.95929947
12IRAK11.75789599
13BCKDK1.71608586
14TEC1.59887888
15BMPR1B1.52343471
16FGR1.47433476
17TLK11.44007250
18PLK41.41646127
19ADRBK21.41107586
20MST41.37271292
21BRSK21.35183570
22FRK1.28529032
23PLK31.20125490
24CCNB11.19468115
25MYLK1.15097284
26SRPK11.11845270
27FER1.11361530
28TNIK1.05778110
29ITK1.04583731
30LMTK21.04301509
31RPS6KA51.03592455
32JAK31.03563617
33MAPK131.02826895
34PINK11.00353115
35BMPR20.97656640
36PHKG20.97650687
37PHKG10.97650687
38EPHB10.95691648
39GRK10.95246107
40CSNK1G20.93085890
41PIK3CG0.92699143
42TXK0.91992714
43GRK50.91958266
44MAP3K140.88835445
45IKBKB0.88444795
46PTK2B0.87240050
47OXSR10.85280268
48PRKCQ0.81833283
49CAMKK20.81122700
50MINK10.80918468
51EIF2AK30.80542066
52BMX0.80061315
53MAPKAPK30.77639476
54CSNK1G30.76635792
55DAPK20.75728719
56EPHA40.74589117
57ADRBK10.74466558
58BRD40.74326614
59IRAK40.73539089
60TIE10.73467426
61CSF1R0.69891028
62OBSCN0.69457351
63WNK30.69169491
64GRK70.68924537
65CDK30.68609533
66BTK0.67905979
67KDR0.66727702
68PDK20.66547390
69ZAK0.64937435
70SYK0.64599732
71WNK10.64490947
72MAP3K40.62429365
73MAP2K70.62007686
74INSRR0.61345539
75ILK0.59951936
76CSNK1D0.57936082
77CSNK1G10.57706545
78MAP2K20.56550574
79PIK3CA0.52838124
80CSNK1A1L0.52593074
81ERBB30.52480916
82MAP2K60.51168490
83CAMK2A0.50244674
84EIF2AK10.48665424
85NEK60.48553570
86PRKG20.48196951
87PRKCE0.47880970
88ZAP700.47319053
89STK240.45442267
90STK30.45283135
91DYRK20.44770348
92DYRK1A0.44334839
93TBK10.42989223
94TNK20.41566973
95MAP3K50.41286679
96VRK10.40669616
97PRKG10.40191401
98MAP3K120.39913381
99BCR0.39824867
100PRKACA0.37634950

Predicted pathways (KEGG)

RankGene SetZ-score
1Collecting duct acid secretion_Homo sapiens_hsa049662.66086639
2Nitrogen metabolism_Homo sapiens_hsa009102.64864979
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.60905381
4Oxidative phosphorylation_Homo sapiens_hsa001902.60725741
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.55707948
6Fatty acid elongation_Homo sapiens_hsa000622.32106931
7RNA polymerase_Homo sapiens_hsa030202.23707284
8Parkinsons disease_Homo sapiens_hsa050122.10490694
9Steroid biosynthesis_Homo sapiens_hsa001001.91930584
10Phototransduction_Homo sapiens_hsa047441.84976075
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.81335887
12Fatty acid biosynthesis_Homo sapiens_hsa000611.77194464
13Graft-versus-host disease_Homo sapiens_hsa053321.76192883
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.75329211
15Intestinal immune network for IgA production_Homo sapiens_hsa046721.72740986
16Peroxisome_Homo sapiens_hsa041461.58176422
17Nicotine addiction_Homo sapiens_hsa050331.57188213
18Butanoate metabolism_Homo sapiens_hsa006501.55848309
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.55268353
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.46884254
21Asthma_Homo sapiens_hsa053101.45354504
22Olfactory transduction_Homo sapiens_hsa047401.44029330
23Linoleic acid metabolism_Homo sapiens_hsa005911.39305448
24ABC transporters_Homo sapiens_hsa020101.35671840
25Regulation of autophagy_Homo sapiens_hsa041401.34944266
26Morphine addiction_Homo sapiens_hsa050321.33709291
27Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32222521
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.31163694
29Rheumatoid arthritis_Homo sapiens_hsa053231.29498659
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.28700705
31Proteasome_Homo sapiens_hsa030501.27996559
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27695240
33Glycerolipid metabolism_Homo sapiens_hsa005611.25712040
34Purine metabolism_Homo sapiens_hsa002301.25451399
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22493048
36Taste transduction_Homo sapiens_hsa047421.22384014
37Pyrimidine metabolism_Homo sapiens_hsa002401.21706642
38Systemic lupus erythematosus_Homo sapiens_hsa053221.20547253
39Huntingtons disease_Homo sapiens_hsa050161.19660604
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17488465
41Basal transcription factors_Homo sapiens_hsa030221.14556370
42Circadian entrainment_Homo sapiens_hsa047131.12635606
43Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11704402
44Propanoate metabolism_Homo sapiens_hsa006401.10301045
45GABAergic synapse_Homo sapiens_hsa047271.09666901
46Fanconi anemia pathway_Homo sapiens_hsa034601.07951047
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07729124
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.04531335
49Arachidonic acid metabolism_Homo sapiens_hsa005901.04356922
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.03609038
51Chemical carcinogenesis_Homo sapiens_hsa052041.01166357
52Fatty acid metabolism_Homo sapiens_hsa012121.00644145
53Serotonergic synapse_Homo sapiens_hsa047261.00314154
54Selenocompound metabolism_Homo sapiens_hsa004500.97947762
55Synaptic vesicle cycle_Homo sapiens_hsa047210.94615196
56Alzheimers disease_Homo sapiens_hsa050100.94296186
57Staphylococcus aureus infection_Homo sapiens_hsa051500.93631251
58Sphingolipid metabolism_Homo sapiens_hsa006000.93469049
59One carbon pool by folate_Homo sapiens_hsa006700.93336722
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90004400
61Protein export_Homo sapiens_hsa030600.88436309
62Retinol metabolism_Homo sapiens_hsa008300.87809124
63Fat digestion and absorption_Homo sapiens_hsa049750.87137812
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85089226
65Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.84953485
66Salivary secretion_Homo sapiens_hsa049700.81875570
67Ether lipid metabolism_Homo sapiens_hsa005650.80745187
68Allograft rejection_Homo sapiens_hsa053300.79964884
69Metabolic pathways_Homo sapiens_hsa011000.79216519
70Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78729724
71beta-Alanine metabolism_Homo sapiens_hsa004100.78401044
72Platelet activation_Homo sapiens_hsa046110.77795373
73Calcium signaling pathway_Homo sapiens_hsa040200.77141793
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76237319
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75625172
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75284631
77Autoimmune thyroid disease_Homo sapiens_hsa053200.74816508
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.73612654
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73539341
80Homologous recombination_Homo sapiens_hsa034400.72147075
81Glutathione metabolism_Homo sapiens_hsa004800.71414566
82Pentose phosphate pathway_Homo sapiens_hsa000300.67551625
83Cardiac muscle contraction_Homo sapiens_hsa042600.65673199
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64942197
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62037559
86Tryptophan metabolism_Homo sapiens_hsa003800.61929378
87Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61536469
88Antigen processing and presentation_Homo sapiens_hsa046120.59832896
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56158317
90Long-term depression_Homo sapiens_hsa047300.54470287
91Tyrosine metabolism_Homo sapiens_hsa003500.52758428
92Shigellosis_Homo sapiens_hsa051310.50489146
93Hematopoietic cell lineage_Homo sapiens_hsa046400.48087701
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.45988725
95Primary immunodeficiency_Homo sapiens_hsa053400.45951022
96Circadian rhythm_Homo sapiens_hsa047100.45387855
97Pancreatic secretion_Homo sapiens_hsa049720.43668808
98Arginine and proline metabolism_Homo sapiens_hsa003300.42809492
99RNA degradation_Homo sapiens_hsa030180.42432634
100Sulfur metabolism_Homo sapiens_hsa009200.41085135

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