CES3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)6.78473750
2drug catabolic process (GO:0042737)6.09640810
3exogenous drug catabolic process (GO:0042738)6.09276459
4cellular glucuronidation (GO:0052695)5.92810472
5urea metabolic process (GO:0019627)5.83120345
6intestinal absorption (GO:0050892)5.70840097
7uronic acid metabolic process (GO:0006063)5.69753208
8glucuronate metabolic process (GO:0019585)5.69753208
9urea cycle (GO:0000050)5.61194247
10ethanol oxidation (GO:0006069)5.55321622
11flavonoid metabolic process (GO:0009812)5.49039402
12nitrogen cycle metabolic process (GO:0071941)5.27061866
13drug metabolic process (GO:0017144)5.20420447
14bile acid and bile salt transport (GO:0015721)5.18908349
15regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.81785932
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.49907222
17L-phenylalanine catabolic process (GO:0006559)4.49907222
18ethanol metabolic process (GO:0006067)4.41060339
19glyoxylate metabolic process (GO:0046487)4.40560053
20L-phenylalanine metabolic process (GO:0006558)4.39644605
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.39644605
22regulation of triglyceride catabolic process (GO:0010896)4.36147219
23arginine metabolic process (GO:0006525)4.31739035
24drug transmembrane transport (GO:0006855)4.24717508
25omega-hydroxylase P450 pathway (GO:0097267)4.24215731
26regulation of protein activation cascade (GO:2000257)4.23513813
27bile acid metabolic process (GO:0008206)4.18324562
28triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.12926124
29fat-soluble vitamin biosynthetic process (GO:0042362)4.12806792
30sulfate transmembrane transport (GO:1902358)4.09347284
31regulation of complement activation (GO:0030449)4.09017080
32regulation of guanylate cyclase activity (GO:0031282)4.03357115
33drug transport (GO:0015893)3.96243284
34alkaloid metabolic process (GO:0009820)3.94930754
35phenylpropanoid metabolic process (GO:0009698)3.94872189
36angiotensin maturation (GO:0002003)3.91957976
37NADH metabolic process (GO:0006734)3.90923585
38renal system process involved in regulation of blood volume (GO:0001977)3.86930175
39positive regulation of triglyceride lipase activity (GO:0061365)3.83859045
40positive regulation of lipoprotein lipase activity (GO:0051006)3.83859045
41complement activation, alternative pathway (GO:0006957)3.82931545
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.82319115
43regulation of bile acid biosynthetic process (GO:0070857)3.79302072
44fructose metabolic process (GO:0006000)3.78347928
45peptidyl-glutamic acid carboxylation (GO:0017187)3.76460637
46protein carboxylation (GO:0018214)3.76460637
47oxidative demethylation (GO:0070989)3.75674343
48complement activation, classical pathway (GO:0006958)3.75569620
49very-low-density lipoprotein particle assembly (GO:0034379)3.72324221
50aromatic amino acid family catabolic process (GO:0009074)3.72183047
51regulation of fibrinolysis (GO:0051917)3.70922654
52plasma lipoprotein particle remodeling (GO:0034369)3.68890945
53protein-lipid complex remodeling (GO:0034368)3.68890945
54macromolecular complex remodeling (GO:0034367)3.68890945
55negative regulation of fibrinolysis (GO:0051918)3.67077617
56intestinal cholesterol absorption (GO:0030299)3.66150683
57regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.56949710
58endocrine process (GO:0050886)3.56949710
59regulation of systemic arterial blood pressure by hormone (GO:0001990)3.56949710
60high-density lipoprotein particle remodeling (GO:0034375)3.54706166
61negative regulation of cholesterol transport (GO:0032375)3.54539406
62negative regulation of sterol transport (GO:0032372)3.54539406
63positive regulation of lipid catabolic process (GO:0050996)3.47846375
64renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.46557454
65regulation of cholesterol homeostasis (GO:2000188)3.44252852
66positive regulation of fatty acid beta-oxidation (GO:0032000)3.42014575
67diacylglycerol metabolic process (GO:0046339)3.39663018
68lipoprotein metabolic process (GO:0042157)3.39387014
69amino-acid betaine metabolic process (GO:0006577)3.38707516
70cellular ketone body metabolic process (GO:0046950)3.37755068
71sulfur amino acid catabolic process (GO:0000098)3.36802231
72triglyceride homeostasis (GO:0070328)3.34637815
73acylglycerol homeostasis (GO:0055090)3.34637815
74protein activation cascade (GO:0072376)3.34253206
75sulfate transport (GO:0008272)3.33970095
76bile acid biosynthetic process (GO:0006699)3.33905086
77positive regulation of respiratory burst (GO:0060267)3.31282841
78blood coagulation, intrinsic pathway (GO:0007597)3.30156930
79phospholipid efflux (GO:0033700)3.29401272
80complement activation (GO:0006956)3.27742324
81creatine metabolic process (GO:0006600)3.22860730
82hormone catabolic process (GO:0042447)3.18641496
83cholesterol efflux (GO:0033344)3.17937485
84citrulline biosynthetic process (GO:0019240)3.14949098
85proline metabolic process (GO:0006560)3.14867486
86plasma lipoprotein particle organization (GO:0071827)3.14766323
87reverse cholesterol transport (GO:0043691)3.12281257
88plasma lipoprotein particle assembly (GO:0034377)3.11746996
89maintenance of gastrointestinal epithelium (GO:0030277)3.06202348
90arginine catabolic process (GO:0006527)3.05687786
91indole-containing compound catabolic process (GO:0042436)3.03094892
92indolalkylamine catabolic process (GO:0046218)3.03094892
93tryptophan catabolic process (GO:0006569)3.03094892
94regulation of cholesterol metabolic process (GO:0090181)3.02880433
95glutamine family amino acid biosynthetic process (GO:0009084)3.02388599
96protein-lipid complex subunit organization (GO:0071825)3.00295399
97oxaloacetate metabolic process (GO:0006107)2.99881749
98regulation of systemic arterial blood pressure (GO:0003073)2.99361162
99xenobiotic metabolic process (GO:0006805)2.99289588
100negative regulation of blood coagulation (GO:0030195)2.98570840

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.47872687
2* RXR_22158963_ChIP-Seq_LIVER_Mouse4.46649287
3PPARA_22158963_ChIP-Seq_LIVER_Mouse4.20274659
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.18753808
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.70048168
6* LXR_22158963_ChIP-Seq_LIVER_Mouse3.48150608
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.29563336
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.28916435
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human3.04797266
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.38844041
11HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.28085682
12GATA4_25053715_ChIP-Seq_YYC3_Human2.25004826
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.14834808
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.14290952
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.13683889
16* LXR_22292898_ChIP-Seq_THP-1_Human2.12558752
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.09702605
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.03259959
19GATA6_25053715_ChIP-Seq_YYC3_Human2.01201939
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.01126582
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.90554231
22DROSHA_22980978_ChIP-Seq_HELA_Human1.90507105
23HNF4A_19822575_ChIP-Seq_HepG2_Human1.83957280
24PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.77845789
25FOXA2_19822575_ChIP-Seq_HepG2_Human1.67424228
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.61980501
27CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59989375
28CTCF_27219007_Chip-Seq_Bcells_Human1.52467839
29FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.51886970
30BCL6_27268052_Chip-Seq_Bcells_Human1.50562954
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.50290248
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.50129001
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48527235
34BCOR_27268052_Chip-Seq_Bcells_Human1.47505241
35P68_20966046_ChIP-Seq_HELA_Human1.47015316
36RACK7_27058665_Chip-Seq_MCF-7_Human1.46917001
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.46475959
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46069702
39E2F1_20622854_ChIP-Seq_HELA_Human1.45072903
40IRF8_22096565_ChIP-ChIP_GC-B_Human1.45008946
41PHF8_20622854_ChIP-Seq_HELA_Human1.44036093
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43119019
43AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.39296408
44SA1_27219007_Chip-Seq_Bcells_Human1.37693456
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34567227
46SMC4_20622854_ChIP-Seq_HELA_Human1.34181084
47BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.32327544
48SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31729255
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.30258530
50SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.29633777
51CEBPB_22108803_ChIP-Seq_LS180_Human1.27092265
52CREB1_26743006_Chip-Seq_LNCaP_Human1.23358331
53SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.23173315
54BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.22682654
55NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19717427
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19067883
57RUNX1_27514584_Chip-Seq_MCF-7_Human1.18774188
58P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16927344
59JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.15794487
60RARG_19884340_ChIP-ChIP_MEFs_Mouse1.15374265
61EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.15009997
62TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.14401113
63VDR_21846776_ChIP-Seq_THP-1_Human1.14330700
64OCT4_20526341_ChIP-Seq_ESCs_Human1.11098012
65RARA_24833708_ChIP-Seq_LIVER_Mouse1.10043181
66P300_27268052_Chip-Seq_Bcells_Human1.09225216
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08260257
68RXRA_24833708_ChIP-Seq_LIVER_Mouse1.07075305
69ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06852168
70* SA1_27219007_Chip-Seq_ERYTHROID_Human1.05989403
71RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05137206
72CTCF_20526341_ChIP-Seq_ESCs_Human1.04711354
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.04309281
74* P53_21459846_ChIP-Seq_SAOS-2_Human1.04118893
75* TP63_22573176_ChIP-Seq_HFKS_Human1.02152327
76NANOG_20526341_ChIP-Seq_ESCs_Human1.01943287
77RAC3_21632823_ChIP-Seq_H3396_Human1.01613569
78SOX2_20726797_ChIP-Seq_SW620_Human1.01444234
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00500578
80GATA1_19941827_ChIP-Seq_MEL_Mouse0.99791124
81ELF1_20517297_ChIP-Seq_JURKAT_Human0.97709245
82CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97457515
83CTCF_21964334_ChIP-Seq_BJAB-B_Human0.97078844
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97051053
85FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95933608
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94778976
87ETS1_21867929_ChIP-Seq_TH2_Mouse0.94672208
88FOXA1_25552417_ChIP-Seq_VCAP_Human0.93663723
89KAP1_22055183_ChIP-Seq_ESCs_Mouse0.92539385
90DNAJC2_21179169_ChIP-ChIP_NT2_Human0.92224342
91STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.91651398
92SOX2_21211035_ChIP-Seq_LN229_Human0.91598749
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91128564
94EGR1_19032775_ChIP-ChIP_M12_Human0.90645257
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90532893
96RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90522250
97TAF2_19829295_ChIP-Seq_ESCs_Human0.90462369
98TCF4_18268006_ChIP-ChIP_LS174T_Human0.87855945
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86927440
100YY1_22570637_ChIP-Seq_MALME-3M_Human0.85949608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.81554207
2MP0005360_urolithiasis6.54113995
3MP0005085_abnormal_gallbladder_physiolo5.42869352
4MP0005365_abnormal_bile_salt4.90873069
5MP0001666_abnormal_nutrient_absorption3.73576731
6MP0008875_abnormal_xenobiotic_pharmacok3.62688722
7MP0003195_calcinosis3.52129425
8MP0002138_abnormal_hepatobiliary_system2.92006604
9MP0003252_abnormal_bile_duct2.60658585
10MP0004043_abnormal_pH_regulation2.55153898
11MP0003183_abnormal_peptide_metabolism2.54330521
12MP0010329_abnormal_lipoprotein_level2.45214420
13MP0003868_abnormal_feces_composition2.43614971
14MP0005332_abnormal_amino_acid2.27821816
15MP0004019_abnormal_vitamin_homeostasis2.13916230
16MP0005670_abnormal_white_adipose2.05600626
17MP0003283_abnormal_digestive_organ2.04402808
18MP0005451_abnormal_body_composition2.02721606
19MP0001764_abnormal_homeostasis1.97420646
20MP0004147_increased_porphyrin_level1.93880576
21MP0003879_abnormal_hair_cell1.88903480
22MP0009840_abnormal_foam_cell1.88517273
23MP0004264_abnormal_extraembryonic_tissu1.74601110
24MP0001664_abnormal_digestion1.71660211
25MP0003866_abnormal_defecation1.58134753
26MP0002876_abnormal_thyroid_physiology1.56866522
27MP0002118_abnormal_lipid_homeostasis1.56855620
28MP0010234_abnormal_vibrissa_follicle1.55865281
29MP0002822_catalepsy1.50178490
30MP0010155_abnormal_intestine_physiology1.48828388
31MP0009643_abnormal_urine_homeostasis1.46980726
32MP0000609_abnormal_liver_physiology1.46347649
33MP0005636_abnormal_mineral_homeostasis1.37233191
34MP0003646_muscle_fatigue1.36914793
35MP0003806_abnormal_nucleotide_metabolis1.36144652
36MP0009697_abnormal_copulation1.33085893
37MP0001765_abnormal_ion_homeostasis1.33067464
38MP0000678_abnormal_parathyroid_gland1.24730841
39MP0004145_abnormal_muscle_electrophysio1.21892803
40MP0005319_abnormal_enzyme/_coenzyme1.18544855
41MP0001873_stomach_inflammation1.15988778
42MP0001661_extended_life_span1.14961840
43MP0000477_abnormal_intestine_morphology1.12945000
44MP0001663_abnormal_digestive_system1.10631661
45MP0005083_abnormal_biliary_tract1.09972221
46MP0005584_abnormal_enzyme/coenzyme_acti1.08474677
47MP0002971_abnormal_brown_adipose1.02657115
48MP0005381_digestive/alimentary_phenotyp0.97415674
49MP0001756_abnormal_urination0.96383656
50MP0005409_darkened_coat_color0.94409174
51MP0004130_abnormal_muscle_cell0.90167341
52MP0004782_abnormal_surfactant_physiolog0.89500281
53MP0004858_abnormal_nervous_system0.88614781
54MP0003315_abnormal_perineum_morphology0.88341395
55MP0008872_abnormal_physiological_respon0.85962126
56MP0009642_abnormal_blood_homeostasis0.85770084
57MP0000490_abnormal_crypts_of0.85757054
58MP0001501_abnormal_sleep_pattern0.82973552
59MP0002136_abnormal_kidney_physiology0.79885555
60MP0003045_fibrosis0.78225719
61MP0009379_abnormal_foot_pigmentation0.77408255
62MP0005058_abnormal_lysosome_morphology0.77361989
63MP0005448_abnormal_energy_balance0.76567780
64MP0000230_abnormal_systemic_arterial0.76100030
65MP0002132_abnormal_respiratory_system0.75048222
66MP0003191_abnormal_cellular_cholesterol0.72890438
67MP0010352_gastrointestinal_tract_polyps0.71605560
68MP0005666_abnormal_adipose_tissue0.70980254
69MP0005266_abnormal_metabolism0.70318032
70MP0000598_abnormal_liver_morphology0.70063992
71MP0005166_decreased_susceptibility_to0.70047086
72MP0005376_homeostasis/metabolism_phenot0.68847875
73MP0002078_abnormal_glucose_homeostasis0.68634774
74MP0005334_abnormal_fat_pad0.68373421
75MP0006036_abnormal_mitochondrial_physio0.68030225
76MP0001986_abnormal_taste_sensitivity0.67808120
77MP0000747_muscle_weakness0.67695343
78MP0000462_abnormal_digestive_system0.67497483
79MP0005535_abnormal_body_temperature0.66317482
80MP0000751_myopathy0.64778550
81MP0003953_abnormal_hormone_level0.63096860
82MP0000538_abnormal_urinary_bladder0.63022845
83MP0004233_abnormal_muscle_weight0.62243316
84MP0002009_preneoplasia0.60599121
85MP0002249_abnormal_larynx_morphology0.59169224
86MP0002098_abnormal_vibrissa_morphology0.57464365
87MP0000566_synostosis0.56689440
88MP0000013_abnormal_adipose_tissue0.56510336
89MP0005330_cardiomyopathy0.55822456
90MP0001485_abnormal_pinna_reflex0.54606892
91MP0009115_abnormal_fat_cell0.50904652
92MP0002168_other_aberrant_phenotype0.49919979
93MP0008469_abnormal_protein_level0.49476102
94MP0005395_other_phenotype0.49053149
95MP0004036_abnormal_muscle_relaxation0.48801931
96MP0002106_abnormal_muscle_physiology0.48225158
97MP0003693_abnormal_embryo_hatching0.45888533
98MP0005647_abnormal_sex_gland0.45209586
99MP0003878_abnormal_ear_physiology0.44122594
100MP0005377_hearing/vestibular/ear_phenot0.44122594

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of monocarboxylic acid metabolism (HP:0010996)6.63767233
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.31095519
3Decreased circulating renin level (HP:0003351)5.12176921
4Hyperactive renin-angiotensin system (HP:0000841)4.93667468
5Hypobetalipoproteinemia (HP:0003563)4.86232067
6Deep venous thrombosis (HP:0002625)4.77445006
7Complement deficiency (HP:0004431)4.59814380
8Prolonged partial thromboplastin time (HP:0003645)4.49370022
9Systemic lupus erythematosus (HP:0002725)4.21765536
10Alkalosis (HP:0001948)4.17781619
11Hemorrhage of the eye (HP:0011885)4.16869475
12Metabolic alkalosis (HP:0200114)4.15621312
13Abnormality of proline metabolism (HP:0010907)4.00474240
14Hydroxyprolinuria (HP:0003080)4.00474240
15Abnormality of renin-angiotensin system (HP:0000847)3.96854439
16Xanthomatosis (HP:0000991)3.92772051
17Abnormality of aromatic amino acid family metabolism (HP:0004338)3.84168670
18Conjugated hyperbilirubinemia (HP:0002908)3.81644542
19Abnormality of complement system (HP:0005339)3.73387346
20Intrahepatic cholestasis (HP:0001406)3.72387487
21Hyperglycinuria (HP:0003108)3.58575686
22Abnormality of pyrimidine metabolism (HP:0004353)3.57852563
23Ileus (HP:0002595)3.42072273
24Malnutrition (HP:0004395)3.36590867
25Flat acetabular roof (HP:0003180)3.34302023
26Hyperammonemia (HP:0001987)3.27305647
27Abnormality of glycine metabolism (HP:0010895)3.26950480
28Abnormality of serine family amino acid metabolism (HP:0010894)3.26950480
29Fat malabsorption (HP:0002630)3.26348155
30Exercise-induced myalgia (HP:0003738)3.24050682
31Joint hemorrhage (HP:0005261)3.23807222
32Glomerulonephritis (HP:0000099)3.07981129
33Abnormality of the 1st metacarpal (HP:0010009)2.98596373
34Hyperlipoproteinemia (HP:0010980)2.98270837
35Hypokalemia (HP:0002900)2.85201947
36Hypolipoproteinemia (HP:0010981)2.81879730
37Cerebral palsy (HP:0100021)2.70415153
38Abnormality of chloride homeostasis (HP:0011422)2.66839187
39Abnormality of nucleobase metabolism (HP:0010932)2.61200841
40Abnormality of potassium homeostasis (HP:0011042)2.60804797
41Myopathic facies (HP:0002058)2.57668522
42Acanthocytosis (HP:0001927)2.57059539
43Abdominal distention (HP:0003270)2.56991457
44Widely patent fontanelles and sutures (HP:0004492)2.55938670
45Gout (HP:0001997)2.55017823
46Hyperaldosteronism (HP:0000859)2.53875818
47Hyponatremia (HP:0002902)2.53822540
48Rhabdomyolysis (HP:0003201)2.50707130
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.50086082
50Dicarboxylic aciduria (HP:0003215)2.50086082
51Hyperkalemia (HP:0002153)2.48001558
52Nephritis (HP:0000123)2.44558396
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.43659801
54Metabolic acidosis (HP:0001942)2.39946075
55Abnormality of the distal phalanx of the thumb (HP:0009617)2.32386630
56Abnormality of carpal bone ossification (HP:0006257)2.31896987
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.25829162
58Abnormality of vitamin metabolism (HP:0100508)2.25305670
59Short phalanx of the thumb (HP:0009660)2.24260276
60Congenital sensorineural hearing impairment (HP:0008527)2.23606456
61Hyperglycinemia (HP:0002154)2.22883553
62Myoglobinuria (HP:0002913)2.20534945
63Epidermoid cyst (HP:0200040)2.19558862
64Abnormality of purine metabolism (HP:0004352)2.16902135
65Glycosuria (HP:0003076)2.15360638
66Abnormality of urine glucose concentration (HP:0011016)2.15360638
67Muscle fiber inclusion bodies (HP:0100299)2.10250417
68Abnormal tarsal ossification (HP:0008369)2.08812061
69Absent phalangeal crease (HP:0006109)2.08766647
70Abnormality of the vitamin B12 metabolism (HP:0004341)2.08029470
71Hyperuricemia (HP:0002149)2.07730668
72Increased purine levels (HP:0004368)2.07730668
73Abnormality of the intrinsic pathway (HP:0010989)2.06417704
74Generalized aminoaciduria (HP:0002909)2.05296423
75Confusion (HP:0001289)2.05275600
76Potter facies (HP:0002009)2.01726078
77Facial shape deformation (HP:0011334)2.01726078
78Nausea (HP:0002018)1.98623058
79Right ventricular cardiomyopathy (HP:0011663)1.97732510
80Focal segmental glomerulosclerosis (HP:0000097)1.97707188
81Nephrolithiasis (HP:0000787)1.95123747
82Ketosis (HP:0001946)1.94464128
83Nemaline bodies (HP:0003798)1.93024661
84Symphalangism affecting the phalanges of the hand (HP:0009773)1.92723841
85Abnormality of serum amino acid levels (HP:0003112)1.92587834
86Proximal tubulopathy (HP:0000114)1.90842865
87Hypercholesterolemia (HP:0003124)1.90271220
88Rickets (HP:0002748)1.89669793
89Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.88841989
90Poikilocytosis (HP:0004447)1.88645613
91Pigmentary retinal degeneration (HP:0001146)1.88493537
92Enlarged kidneys (HP:0000105)1.87448711
93Steatorrhea (HP:0002570)1.86265811
94Neonatal onset (HP:0003623)1.85996360
95Abnormality of vitamin B metabolism (HP:0004340)1.83928480
96Glomerulosclerosis (HP:0000096)1.82034398
97Abnormal hand bone ossification (HP:0010660)1.79648365
98Gonadal dysgenesis (HP:0000133)1.79143426
99Abnormality of fatty-acid metabolism (HP:0004359)1.78974568
100Abnormality of the common coagulation pathway (HP:0010990)1.78405762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B4.70131349
2MST1R4.28263655
3EPHA23.64557074
4RIPK13.55735463
5ERN13.44449677
6PIK3CA3.00895168
7OBSCN2.91445230
8MAP2K62.67220059
9TRIB32.39429599
10LMTK22.19939863
11TAOK22.00782729
12PDK22.00218109
13WNK41.92021885
14STK391.89518589
15EEF2K1.86167305
16FGFR41.82978541
17ICK1.78491271
18PRPF4B1.72017692
19PRKG21.69205700
20PRKAA21.66617200
21FRK1.64993105
22PHKG11.64802303
23PHKG21.64802303
24NME11.61788032
25LATS11.52669931
26MAPK111.51028616
27CDK121.50213480
28OXSR11.45623622
29MET1.38991729
30BCKDK1.25363626
31TESK21.24179130
32MAP3K111.23874015
33SIK11.23259668
34MAP2K21.22954566
35MAPKAPK31.21321122
36PTK61.21035976
37MAP3K71.17456871
38PDPK11.17050934
39DYRK1B1.14713243
40INSRR1.11110667
41PIK3CG1.04642588
42PRKAA10.97065764
43MAP3K100.96192581
44EPHA30.94095378
45GRK60.93734973
46MAP2K30.85672121
47FGFR30.84897961
48TLK10.81066203
49PKN20.80996179
50ERBB20.80686086
51SMG10.79533807
52MATK0.78623426
53PDK10.76251835
54MAP3K10.74903420
55MAP3K20.72936545
56CDK190.72896886
57PRKACG0.72124096
58MAP4K10.71875892
59MAP2K40.71001006
60PIM20.70850192
61GRK10.67667347
62KDR0.64636177
63FER0.60707425
64MELK0.60499771
65MAPK120.56874620
66TYK20.56675236
67EPHB20.52379803
68MAP3K50.50208904
69CAMK40.49991677
70RET0.47955862
71EPHB10.46541535
72STK380.46025937
73DDR20.44623837
74TTN0.42607141
75SIK20.38653072
76BLK0.38652462
77TBK10.37841280
78NLK0.36892604
79EPHA40.33977236
80RPS6KA60.33318501
81BMX0.32572463
82CDC42BPA0.31723445
83RPS6KA50.31604342
84PRKCA0.31170446
85TAOK10.30318464
86MUSK0.30063275
87PRKACA0.29901880
88NEK90.29643777
89PINK10.29290775
90ADRBK20.29077376
91MAP2K10.28601764
92ADRBK10.28561123
93MARK20.27871465
94CSF1R0.27449445
95STK38L0.27025292
96CSNK1A10.26619618
97MAPK30.25997729
98ZAK0.25216380
99RPS6KL10.25016251
100RPS6KC10.25016251

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.09217904
2Caffeine metabolism_Homo sapiens_hsa002323.48815081
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.16916532
4Arginine biosynthesis_Homo sapiens_hsa002202.94786281
5Fat digestion and absorption_Homo sapiens_hsa049752.63799202
6Retinol metabolism_Homo sapiens_hsa008302.60837923
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.60188641
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.54180445
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52309035
10Histidine metabolism_Homo sapiens_hsa003402.51460861
11Chemical carcinogenesis_Homo sapiens_hsa052042.32964529
12Steroid hormone biosynthesis_Homo sapiens_hsa001402.32800646
13Fatty acid degradation_Homo sapiens_hsa000712.29717205
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.27360634
15Drug metabolism - other enzymes_Homo sapiens_hsa009832.22589507
16Primary bile acid biosynthesis_Homo sapiens_hsa001202.16815651
17Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.13403368
18Starch and sucrose metabolism_Homo sapiens_hsa005002.03697746
19Bile secretion_Homo sapiens_hsa049762.00849890
20Sulfur metabolism_Homo sapiens_hsa009201.96268843
21Phenylalanine metabolism_Homo sapiens_hsa003601.89428855
22Complement and coagulation cascades_Homo sapiens_hsa046101.88902915
23Tryptophan metabolism_Homo sapiens_hsa003801.81569445
24Nitrogen metabolism_Homo sapiens_hsa009101.79272748
25Butanoate metabolism_Homo sapiens_hsa006501.72251281
26Linoleic acid metabolism_Homo sapiens_hsa005911.71004280
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.69209092
28Fructose and mannose metabolism_Homo sapiens_hsa000511.67044220
29Vitamin digestion and absorption_Homo sapiens_hsa049771.64411113
30Arginine and proline metabolism_Homo sapiens_hsa003301.62009770
31PPAR signaling pathway_Homo sapiens_hsa033201.61812303
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58952446
33Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.57060525
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54773895
35Sulfur relay system_Homo sapiens_hsa041221.52146878
36Tyrosine metabolism_Homo sapiens_hsa003501.45432810
37Renin-angiotensin system_Homo sapiens_hsa046141.33265833
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28969899
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.25078383
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21501574
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19385347
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.17652701
43Mineral absorption_Homo sapiens_hsa049781.15123643
44Arachidonic acid metabolism_Homo sapiens_hsa005901.09763909
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.09244106
46Biosynthesis of amino acids_Homo sapiens_hsa012301.07752897
47Peroxisome_Homo sapiens_hsa041461.07086892
48alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.06562146
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05925533
50Glycerolipid metabolism_Homo sapiens_hsa005611.01190214
51ABC transporters_Homo sapiens_hsa020100.99070400
52Pyruvate metabolism_Homo sapiens_hsa006200.96706148
53Galactose metabolism_Homo sapiens_hsa000520.92922721
54Fatty acid metabolism_Homo sapiens_hsa012120.90527199
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.89905997
56Carbon metabolism_Homo sapiens_hsa012000.83866617
57Propanoate metabolism_Homo sapiens_hsa006400.80998002
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78886729
59beta-Alanine metabolism_Homo sapiens_hsa004100.75348272
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74039250
61Cysteine and methionine metabolism_Homo sapiens_hsa002700.71190942
62Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69904014
63Pancreatic secretion_Homo sapiens_hsa049720.62939743
64Staphylococcus aureus infection_Homo sapiens_hsa051500.61495644
65Protein digestion and absorption_Homo sapiens_hsa049740.61230914
66Other glycan degradation_Homo sapiens_hsa005110.56877151
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54728176
68Metabolic pathways_Homo sapiens_hsa011000.49360521
69Lysine degradation_Homo sapiens_hsa003100.49221008
70Sphingolipid metabolism_Homo sapiens_hsa006000.46441190
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42994926
72Pentose phosphate pathway_Homo sapiens_hsa000300.42340372
73Ether lipid metabolism_Homo sapiens_hsa005650.42183564
74Glutathione metabolism_Homo sapiens_hsa004800.41295762
75Insulin resistance_Homo sapiens_hsa049310.40558711
76Glucagon signaling pathway_Homo sapiens_hsa049220.38959653
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38409288
78Fatty acid biosynthesis_Homo sapiens_hsa000610.34984372
79Ovarian steroidogenesis_Homo sapiens_hsa049130.34388533
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.33042574
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31956055
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.29309814
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20037008
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18950722
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.17710398
86Vitamin B6 metabolism_Homo sapiens_hsa007500.15434048
87AMPK signaling pathway_Homo sapiens_hsa041520.14725656
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14284410
89One carbon pool by folate_Homo sapiens_hsa006700.11231851
90Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07704475
91Fatty acid elongation_Homo sapiens_hsa000620.07220826
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.06820237
93Pertussis_Homo sapiens_hsa051330.06524130
94Intestinal immune network for IgA production_Homo sapiens_hsa046720.05391399
95Prion diseases_Homo sapiens_hsa050200.01463947
96Circadian rhythm_Homo sapiens_hsa04710-0.0768028
97Folate biosynthesis_Homo sapiens_hsa00790-0.0656963
98Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0437983
99Insulin signaling pathway_Homo sapiens_hsa04910-0.0037675
100Systemic lupus erythematosus_Homo sapiens_hsa05322-0.0036993

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