CER1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phospholipid scrambling (GO:0017121)7.95847071
2anterior/posterior axis specification, embryo (GO:0008595)7.29034436
3DNA replication-dependent nucleosome organization (GO:0034723)5.43039268
4DNA replication-dependent nucleosome assembly (GO:0006335)5.43039268
5* anterior/posterior axis specification (GO:0009948)5.16643747
6embryonic axis specification (GO:0000578)5.14681726
7regulation of gastrulation (GO:0010470)5.12542253
8* regulation of mesoderm development (GO:2000380)4.95306170
9female gonad development (GO:0008585)4.81715228
10CENP-A containing nucleosome assembly (GO:0034080)4.74012933
11embryonic foregut morphogenesis (GO:0048617)4.73808850
12presynaptic membrane assembly (GO:0097105)4.64412799
13daunorubicin metabolic process (GO:0044597)4.63194109
14polyketide metabolic process (GO:0030638)4.63194109
15doxorubicin metabolic process (GO:0044598)4.63194109
16chromatin remodeling at centromere (GO:0031055)4.60563820
17presynaptic membrane organization (GO:0097090)4.57991674
18histone exchange (GO:0043486)4.57597620
19SMAD protein signal transduction (GO:0060395)4.57463808
20positive regulation of cardiac muscle cell proliferation (GO:0060045)4.53249459
21positive regulation of SMAD protein import into nucleus (GO:0060391)4.44389340
22L-serine transport (GO:0015825)4.43820440
23embryonic pattern specification (GO:0009880)4.43000998
24glomerulus development (GO:0032835)4.42319377
25dorsal/ventral axis specification (GO:0009950)4.37467755
26* gastrulation (GO:0007369)4.36153465
27mitochondrial fragmentation involved in apoptotic process (GO:0043653)4.32023172
28regulation of cardioblast differentiation (GO:0051890)4.31080038
29* cell migration involved in gastrulation (GO:0042074)4.23597877
30negative regulation of cell fate specification (GO:0009996)4.23508480
31* regulation of activin receptor signaling pathway (GO:0032925)4.22161705
32pericardium development (GO:0060039)4.16097598
33superoxide anion generation (GO:0042554)4.11563554
34regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901214.05814126
35positive regulation of cardiac muscle tissue growth (GO:0055023)3.98929571
36mitotic G2/M transition checkpoint (GO:0044818)3.98086277
37kinetochore organization (GO:0051383)3.94569691
38DNA double-strand break processing (GO:0000729)3.92735690
39negative regulation of axon extension involved in axon guidance (GO:0048843)3.91701083
40endoderm formation (GO:0001706)3.87879273
41vitamin catabolic process (GO:0009111)3.85830793
42fat-soluble vitamin catabolic process (GO:0042363)3.85830793
43positive regulation of cardiac muscle tissue development (GO:0055025)3.84971975
44kinetochore assembly (GO:0051382)3.84789658
45facial nerve structural organization (GO:0021612)3.77670766
46DNA replication-independent nucleosome assembly (GO:0006336)3.75248201
47DNA replication-independent nucleosome organization (GO:0034724)3.75248201
48activin receptor signaling pathway (GO:0032924)3.75028792
49lung morphogenesis (GO:0060425)3.73617504
50cerebral cortex radially oriented cell migration (GO:0021799)3.72621262
51mesonephros development (GO:0001823)3.70893448
52serine transport (GO:0032329)3.70258006
53regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.65136452
54regulation of pigment cell differentiation (GO:0050932)3.63396114
55regulation of cardiac muscle cell proliferation (GO:0060043)3.60320217
56maternal placenta development (GO:0001893)3.57122462
57regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.55742212
58cell proliferation in forebrain (GO:0021846)3.55699139
59genitalia morphogenesis (GO:0035112)3.55302641
60DNA replication checkpoint (GO:0000076)3.50433156
61uterus development (GO:0060065)3.42233954
62mesenchymal cell differentiation involved in kidney development (GO:0072161)3.40409075
63mesenchymal cell differentiation involved in renal system development (GO:2001012)3.40409075
64organ formation (GO:0048645)3.40136669
65positive regulation of cellular amide metabolic process (GO:0034250)3.39072015
66otic vesicle formation (GO:0030916)3.37952332
67positive regulation of heart growth (GO:0060421)3.37399330
68regulation of SMAD protein import into nucleus (GO:0060390)3.36918081
69positive regulation of gastrulation (GO:2000543)3.36790738
70regulation of RIG-I signaling pathway (GO:0039535)3.36336040
71regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.35611580
72startle response (GO:0001964)3.34430713
73regulation of cofactor metabolic process (GO:0051193)3.30413084
74regulation of coenzyme metabolic process (GO:0051196)3.30413084
75mitotic G2 DNA damage checkpoint (GO:0007095)3.29515289
76regulation of timing of cell differentiation (GO:0048505)3.27508864
77Rap protein signal transduction (GO:0032486)3.26595037
78opioid receptor signaling pathway (GO:0038003)3.26273957
79cardiocyte differentiation (GO:0035051)3.25986763
80cranial nerve structural organization (GO:0021604)3.23674004
81formation of primary germ layer (GO:0001704)3.23609542
82* axis specification (GO:0009798)3.23169980
83gastrulation with mouth forming second (GO:0001702)3.21475580
84negative regulation of embryonic development (GO:0045992)3.21267822
85regulation of acyl-CoA biosynthetic process (GO:0050812)3.21205549
86digestive tract morphogenesis (GO:0048546)3.20628333
87regulation of cardiac muscle tissue development (GO:0055024)3.18732298
88regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18114444
89cellular response to hepatocyte growth factor stimulus (GO:0035729)3.17234766
90response to hepatocyte growth factor (GO:0035728)3.17234766
91positive regulation of striated muscle tissue development (GO:0045844)3.14598823
92positive regulation of muscle organ development (GO:0048636)3.14598823
93embryonic process involved in female pregnancy (GO:0060136)3.14121048
94regulation of axon extension involved in axon guidance (GO:0048841)3.12464467
95head development (GO:0060322)3.09672329
96* signal transduction involved in regulation of gene expression (GO:0023019)3.09544031
97primitive streak formation (GO:0090009)3.08808422
98positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)3.08587462
99positive regulation of muscle tissue development (GO:1901863)3.08257431
100regulation of development, heterochronic (GO:0040034)3.07891195
101positive regulation of protein homodimerization activity (GO:0090073)3.06927494
102fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.06549248
103negative regulation of synaptic transmission, GABAergic (GO:0032229)3.03523385
104urogenital system development (GO:0001655)3.00419559
105bone remodeling (GO:0046849)3.00143731
106negative regulation of axon guidance (GO:1902668)2.97536499
107negative regulation of homotypic cell-cell adhesion (GO:0034111)2.95289704
108cell differentiation involved in metanephros development (GO:0072202)2.95208568
109DNA deamination (GO:0045006)2.93187210
110response to pheromone (GO:0019236)2.92101018
111forebrain neuron differentiation (GO:0021879)2.91700805
112somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.91646043
113isotype switching (GO:0045190)2.91646043
114somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.91646043
115specification of organ identity (GO:0010092)2.91541576
116interferon-gamma production (GO:0032609)2.91091474
117neural crest cell development (GO:0014032)2.89654490
118rRNA modification (GO:0000154)2.88715503
119mesenchymal to epithelial transition (GO:0060231)2.88148977
120postsynaptic membrane organization (GO:0001941)2.87716385
121regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393)2.87269636
122regulation of transforming growth factor beta1 production (GO:0032908)2.86025178
123somite rostral/caudal axis specification (GO:0032525)2.85978170
124replication fork processing (GO:0031297)2.85902005
125* negative regulation of activin receptor signaling pathway (GO:0032926)2.84240737
126negative regulation of mast cell activation (GO:0033004)2.83168395
127heart field specification (GO:0003128)2.82826093
128secondary heart field specification (GO:0003139)2.82826093
129negative regulation of cell fate commitment (GO:0010454)2.82050087
130regulation of cell fate specification (GO:0042659)2.81437985
131limb bud formation (GO:0060174)2.81296036
132nodal signaling pathway (GO:0038092)2.81006941
133cardiac muscle cell differentiation (GO:0055007)2.80918763
134mesenchymal cell development (GO:0014031)2.80883555
135negative regulation of osteoblast proliferation (GO:0033689)2.80752852
136mitotic metaphase plate congression (GO:0007080)2.80205327
137spinal cord association neuron differentiation (GO:0021527)2.79644865
138mitochondrial fission (GO:0000266)2.79581411
139rRNA methylation (GO:0031167)2.78963978
140neurotransmitter-gated ion channel clustering (GO:0072578)2.77313750
141positive regulation of developmental pigmentation (GO:0048087)2.73359278
142regulation of synapse maturation (GO:0090128)2.72774675
143natural killer cell activation involved in immune response (GO:0002323)2.72130124
144positive regulation of amino acid transport (GO:0051957)2.70937419
145embryonic viscerocranium morphogenesis (GO:0048703)2.68825259
146DNA integration (GO:0015074)2.67300577
147dentate gyrus development (GO:0021542)2.66046602
148regulation of non-canonical Wnt signaling pathway (GO:2000050)2.63859526
149serotonin receptor signaling pathway (GO:0007210)2.61151896
150aminoglycoside antibiotic metabolic process (GO:0030647)2.60178217
151positive regulation of interleukin-8 secretion (GO:2000484)2.59787383
152CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.58403693
153regulation of interleukin-8 secretion (GO:2000482)2.58089497
154replicative senescence (GO:0090399)2.56940261
155motor neuron axon guidance (GO:0008045)2.55558775
156ganglion development (GO:0061548)2.53385038
157detection of molecule of bacterial origin (GO:0032490)2.53102746
158single strand break repair (GO:0000012)2.52417918
159protein heterotetramerization (GO:0051290)2.52325049
160motile cilium assembly (GO:0044458)2.51026918
161GTP biosynthetic process (GO:0006183)2.50955789
162retina layer formation (GO:0010842)2.49642844
163centriole assembly (GO:0098534)2.48960203
164cardiac chamber formation (GO:0003207)2.48771428
165kidney morphogenesis (GO:0060993)2.47194071
166positive regulation of DNA-dependent DNA replication (GO:2000105)2.47035392
167cell differentiation involved in kidney development (GO:0061005)2.44694074
168keratinocyte development (GO:0003334)2.44670696
169cellular anion homeostasis (GO:0030002)2.44645498
170developmental pigmentation (GO:0048066)2.43235740
171regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.42920656
172mesenchymal cell differentiation (GO:0048762)2.41099063
173response to UV-B (GO:0010224)2.39674292
174cardiac ventricle formation (GO:0003211)2.39479408
175regulation of feeding behavior (GO:0060259)2.38060814
176epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.37774269
177negative regulation of myeloid cell apoptotic process (GO:0033033)2.37342486
178viral protein processing (GO:0019082)2.36750653
179stem cell development (GO:0048864)2.36251760
180negative regulation of calcium ion transport into cytosol (GO:0010523)2.34060964
181prostate gland growth (GO:0060736)2.32863281
182negative regulation of keratinocyte proliferation (GO:0010839)2.31959897
183viral genome replication (GO:0019079)2.29736599
184cranial nerve morphogenesis (GO:0021602)2.29655614
185positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.28969032

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.31988986
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.31988986
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.31988986
4GBX2_23144817_ChIP-Seq_PC3_Human4.21410950
5* SMAD3_21741376_ChIP-Seq_HESCs_Human3.94163183
6EZH2_22144423_ChIP-Seq_EOC_Human3.86071077
7E2F7_22180533_ChIP-Seq_HELA_Human3.57350599
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.28391428
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.21174172
10* SMAD4_21741376_ChIP-Seq_HESCs_Human3.14939510
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.99091915
12BMI1_23680149_ChIP-Seq_NPCS_Mouse2.84933061
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67597297
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.58934835
15EOMES_21245162_ChIP-Seq_HESCs_Human2.57012275
16EED_16625203_ChIP-ChIP_MESCs_Mouse2.51603650
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.49657301
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.42584074
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41600416
20CBX2_27304074_Chip-Seq_ESCs_Mouse2.41181988
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.36239647
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.32418981
23EZH2_27304074_Chip-Seq_ESCs_Mouse2.27706195
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.27163639
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26190148
26* SMAD2/3_21741376_ChIP-Seq_EPCs_Human2.23976851
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22020767
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.21576801
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15674449
30SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10191317
31IGF1R_20145208_ChIP-Seq_DFB_Human2.08557638
32TP63_19390658_ChIP-ChIP_HaCaT_Human2.05700778
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02632772
34P300_19829295_ChIP-Seq_ESCs_Human2.01941827
35POU5F1_16153702_ChIP-ChIP_HESCs_Human2.01506978
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.98236478
37TAF15_26573619_Chip-Seq_HEK293_Human1.96759880
38SUZ12_27294783_Chip-Seq_NPCs_Mouse1.96188828
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95471416
40* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95450866
41CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91169580
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88442311
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.86758029
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86353142
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84891515
46AR_21909140_ChIP-Seq_LNCAP_Human1.84735561
47RNF2_27304074_Chip-Seq_NSC_Mouse1.84014302
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.82875818
49* SMAD4_21741376_ChIP-Seq_EPCs_Human1.81969858
50* NANOG_16153702_ChIP-ChIP_HESCs_Human1.80083227
51ELK1_19687146_ChIP-ChIP_HELA_Human1.79994441
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79392296
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79028955
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79028955
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.77971335
56EST1_17652178_ChIP-ChIP_JURKAT_Human1.75807402
57BCAT_22108803_ChIP-Seq_LS180_Human1.73814750
58P53_22387025_ChIP-Seq_ESCs_Mouse1.73552271
59STAT3_18555785_Chip-Seq_ESCs_Mouse1.72893018
60HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.71931897
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.71511205
62* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.71274183
63TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.70663501
64FUS_26573619_Chip-Seq_HEK293_Human1.66304496
65SUZ12_18555785_Chip-Seq_ESCs_Mouse1.66068541
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.65873969
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64407818
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.63834507
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.62574464
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.62055602
71CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61587353
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60223104
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59464296
74FOXM1_23109430_ChIP-Seq_U2OS_Human1.56941572
75CMYC_18555785_Chip-Seq_ESCs_Mouse1.56415032
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.56338815
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.55712616
78NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.55218796
79SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.54184261
80TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.51973572
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.50805692
82P300_18555785_Chip-Seq_ESCs_Mouse1.50525288
83VDR_22108803_ChIP-Seq_LS180_Human1.49313316
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.49105498
85SMAD4_21799915_ChIP-Seq_A2780_Human1.46811880
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.45308430
87RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43993361
88ER_23166858_ChIP-Seq_MCF-7_Human1.43804634
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41957469
90SOX2_18555785_Chip-Seq_ESCs_Mouse1.41913960
91ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.41307357
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.41103456
93* SMAD3_21741376_ChIP-Seq_EPCs_Human1.40948442
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.39258271
95OCT4_18555785_Chip-Seq_ESCs_Mouse1.39067641
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.38615153
97RNF2_27304074_Chip-Seq_ESCs_Mouse1.37479585
98ZNF274_21170338_ChIP-Seq_K562_Hela1.37294118
99EWS_26573619_Chip-Seq_HEK293_Human1.35861173
100ZFX_18555785_Chip-Seq_ESCs_Mouse1.35638832
101IRF1_19129219_ChIP-ChIP_H3396_Human1.34298954
102CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32531447
103CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26415927
104PU1_27457419_Chip-Seq_LIVER_Mouse1.25379549
105SUZ12_27294783_Chip-Seq_ESCs_Mouse1.23432663
106KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21496967
107KLF4_18555785_Chip-Seq_ESCs_Mouse1.21462819
108AR_21572438_ChIP-Seq_LNCaP_Human1.21366427
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21112145
110SALL4_18804426_ChIP-ChIP_XEN_Mouse1.21078820
111TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19151289
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18651675
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18651675
114CTCF_18555785_Chip-Seq_ESCs_Mouse1.17133619
115JUN_21703547_ChIP-Seq_K562_Human1.16339078
116SMAD_19615063_ChIP-ChIP_OVARY_Human1.15571780
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14775886
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.14389223
119TCF4_22108803_ChIP-Seq_LS180_Human1.14368308
120ESRRB_18555785_Chip-Seq_ESCs_Mouse1.14363626
121RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14341850
122TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13430026
123MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12135291
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11405423
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11142017
126AR_25329375_ChIP-Seq_VCAP_Human1.10843297
127MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08693319
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08317224
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08275491
130CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08212781
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08083859
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07820232
133MYC_18940864_ChIP-ChIP_HL60_Human1.07571615
134SOX9_26525672_Chip-Seq_HEART_Mouse1.07283297
135SMAD1_18555785_Chip-Seq_ESCs_Mouse1.07103175
136CRX_20693478_ChIP-Seq_RETINA_Mouse1.05759674
137TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05745936
138TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05684533
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05634317
140NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05634317
141FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04636876
142RUNX2_22187159_ChIP-Seq_PCA_Human1.04347788
143CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.04326552
144NANOG_19829295_ChIP-Seq_ESCs_Human1.03933878
145SOX2_19829295_ChIP-Seq_ESCs_Human1.03933878
146SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03624530
147SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.02943958
148TP53_18474530_ChIP-ChIP_U2OS_Human1.02288827
149TCF4_23295773_ChIP-Seq_U87_Human1.01292935
150NOTCH1_21737748_ChIP-Seq_TLL_Human1.00461473
151PRDM14_20953172_ChIP-Seq_ESCs_Human1.00373116
152TP53_20018659_ChIP-ChIP_R1E_Mouse1.00327640
153POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00254711
154OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00019295
155EP300_21415370_ChIP-Seq_HL-1_Mouse0.97878196
156OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97816444
157HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97763386
158KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94950466
159CDX2_19796622_ChIP-Seq_MESCs_Mouse0.94122715
160SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94052155
161NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93761206
162TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92777206
163GATA1_26923725_Chip-Seq_HPCs_Mouse0.91518529
164NELFA_20434984_ChIP-Seq_ESCs_Mouse0.90872584
165FLI1_21867929_ChIP-Seq_TH2_Mouse0.90008479
166SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.89374992
167VDR_23849224_ChIP-Seq_CD4+_Human0.87758397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.56732726
2MP0006054_spinal_hemorrhage3.42270887
3MP0001188_hyperpigmentation3.20144926
4MP0004133_heterotaxia2.93437096
5MP0000566_synostosis2.88493466
6MP0009697_abnormal_copulation2.80823652
7MP0005171_absent_coat_pigmentation2.78141844
8* MP0003890_abnormal_embryonic-extraembry2.62190813
9MP0003283_abnormal_digestive_organ2.53739082
10MP0009379_abnormal_foot_pigmentation2.51895195
11MP0002277_abnormal_respiratory_mucosa2.48910974
12MP0000372_irregular_coat_pigmentation2.31471123
13MP0000678_abnormal_parathyroid_gland2.23174215
14MP0003787_abnormal_imprinting2.19895756
15MP0003195_calcinosis2.18323893
16MP0010030_abnormal_orbit_morphology2.16435130
17MP0003136_yellow_coat_color2.15528882
18MP0002736_abnormal_nociception_after2.10340573
19MP0002249_abnormal_larynx_morphology2.07516823
20MP0002254_reproductive_system_inflammat2.04431481
21MP0001986_abnormal_taste_sensitivity2.02283235
22MP0000049_abnormal_middle_ear2.02209520
23MP0010094_abnormal_chromosome_stability1.96380674
24MP0005646_abnormal_pituitary_gland1.88802372
25MP0001293_anophthalmia1.88091106
26MP0004957_abnormal_blastocyst_morpholog1.87265065
27MP0002132_abnormal_respiratory_system1.85813705
28MP0000015_abnormal_ear_pigmentation1.84972662
29MP0003941_abnormal_skin_development1.84739265
30MP0003880_abnormal_central_pattern1.81339875
31* MP0002084_abnormal_developmental_patter1.76103810
32MP0002735_abnormal_chemical_nociception1.71126792
33MP0001968_abnormal_touch/_nociception1.70758250
34MP0001984_abnormal_olfaction1.67106429
35MP0004381_abnormal_hair_follicle1.66501651
36* MP0001672_abnormal_embryogenesis/_devel1.66136976
37* MP0005380_embryogenesis_phenotype1.66136976
38MP0002102_abnormal_ear_morphology1.65445269
39MP0000462_abnormal_digestive_system1.62604016
40MP0008995_early_reproductive_senescence1.50763720
41MP0002876_abnormal_thyroid_physiology1.50686420
42MP0001486_abnormal_startle_reflex1.49135947
43MP0002938_white_spotting1.49084300
44MP0002638_abnormal_pupillary_reflex1.48675852
45MP0005075_abnormal_melanosome_morpholog1.46644038
46MP0003121_genomic_imprinting1.45236412
47MP0006072_abnormal_retinal_apoptosis1.43884482
48MP0004264_abnormal_extraembryonic_tissu1.41286799
49MP0000516_abnormal_urinary_system1.41273172
50MP0005367_renal/urinary_system_phenotyp1.41273172
51MP0003122_maternal_imprinting1.36698493
52MP0003938_abnormal_ear_development1.36091365
53MP0005084_abnormal_gallbladder_morpholo1.34662648
54MP0002177_abnormal_outer_ear1.34608514
55MP0003119_abnormal_digestive_system1.34563072
56MP0008004_abnormal_stomach_pH1.33971305
57MP0003984_embryonic_growth_retardation1.31852364
58MP0002088_abnormal_embryonic_growth/wei1.31345827
59MP0003943_abnormal_hepatobiliary_system1.30699565
60MP0000681_abnormal_thyroid_gland1.29569465
61MP0009046_muscle_twitch1.29544179
62MP0003137_abnormal_impulse_conducting1.28610348
63* MP0002111_abnormal_tail_morphology1.28511259
64MP0003567_abnormal_fetal_cardiomyocyte1.28225589
65MP0002160_abnormal_reproductive_system1.28040853
66* MP0002085_abnormal_embryonic_tissue1.27572319
67MP0005394_taste/olfaction_phenotype1.27424372
68MP0005499_abnormal_olfactory_system1.27424372
69MP0005409_darkened_coat_color1.27219342
70MP0000026_abnormal_inner_ear1.26114439
71MP0008058_abnormal_DNA_repair1.26018672
72MP0008789_abnormal_olfactory_epithelium1.24726528
73MP0002751_abnormal_autonomic_nervous1.21539446
74MP0001730_embryonic_growth_arrest1.21323575
75MP0003123_paternal_imprinting1.21089051
76MP0006276_abnormal_autonomic_nervous1.20959859
77MP0001963_abnormal_hearing_physiology1.18414532
78MP0005645_abnormal_hypothalamus_physiol1.17188248
79MP0005408_hypopigmentation1.17081848
80MP0003942_abnormal_urinary_system1.14864913
81MP0009745_abnormal_behavioral_response1.14713161
82MP0001919_abnormal_reproductive_system1.13622564
83MP0003279_aneurysm1.12347098
84MP0005389_reproductive_system_phenotype1.11065710
85MP0008057_abnormal_DNA_replication1.10728532
86MP0003935_abnormal_craniofacial_develop1.10567860
87MP0003936_abnormal_reproductive_system1.08315352
88MP0001348_abnormal_lacrimal_gland1.07886000
89MP0002932_abnormal_joint_morphology1.07585128
90MP0002127_abnormal_cardiovascular_syste1.07394980
91MP0004142_abnormal_muscle_tone1.06247858
92MP0002148_abnormal_hypersensitivity_rea1.06239543
93MP0010386_abnormal_urinary_bladder1.04962598
94MP0002557_abnormal_social/conspecific_i1.04911274
95MP0003385_abnormal_body_wall1.04876241
96MP0005379_endocrine/exocrine_gland_phen1.04729079
97MP0003937_abnormal_limbs/digits/tail_de1.03849095
98MP0000538_abnormal_urinary_bladder1.03071638
99MP0001697_abnormal_embryo_size1.03056759
100MP0005248_abnormal_Harderian_gland1.03028686
101MP0003077_abnormal_cell_cycle1.02983982
102MP0002086_abnormal_extraembryonic_tissu1.02913962
103MP0003786_premature_aging1.02554926
104MP0004782_abnormal_surfactant_physiolog1.02363346
105* MP0002572_abnormal_emotion/affect_behav1.02025519
106MP0002109_abnormal_limb_morphology1.01671249
107MP0003566_abnormal_cell_adhesion1.00425898
108MP0002925_abnormal_cardiovascular_devel0.99910659
109MP0000762_abnormal_tongue_morphology0.99791739
110MP0002163_abnormal_gland_morphology0.99734387
111MP0002233_abnormal_nose_morphology0.98799995
112MP0001529_abnormal_vocalization0.98140330
113MP0005174_abnormal_tail_pigmentation0.96116009
114MP0004215_abnormal_myocardial_fiber0.95626497
115MP0002067_abnormal_sensory_capabilities0.94178634
116MP0000631_abnormal_neuroendocrine_gland0.92989300
117MP0000778_abnormal_nervous_system0.92711416
118MP0004272_abnormal_basement_membrane0.92567761
119MP0002095_abnormal_skin_pigmentation0.91850228
120MP0001485_abnormal_pinna_reflex0.91784527
121MP0003879_abnormal_hair_cell0.90852924
122MP0004145_abnormal_muscle_electrophysio0.86875839
123MP0000432_abnormal_head_morphology0.85204311
124MP0002234_abnormal_pharynx_morphology0.83048184
125MP0005423_abnormal_somatic_nervous0.80421569
126MP0004085_abnormal_heartbeat0.78994572
127MP0005330_cardiomyopathy0.78005286
128MP0008877_abnormal_DNA_methylation0.78003534
129MP0008872_abnormal_physiological_respon0.76965633
130* MP0002080_prenatal_lethality0.76321616
131MP0002064_seizures0.75859833
132MP0002272_abnormal_nervous_system0.75581178
133MP0003693_abnormal_embryo_hatching0.73263789
134MP0001727_abnormal_embryo_implantation0.72576360
135* MP0002116_abnormal_craniofacial_bone0.72173324
136MP0003221_abnormal_cardiomyocyte_apopto0.71983103
137MP0004185_abnormal_adipocyte_glucose0.67763159
138* MP0003861_abnormal_nervous_system0.67171569
139MP0003635_abnormal_synaptic_transmissio0.66064444
140MP0002697_abnormal_eye_size0.65765452
141MP0005391_vision/eye_phenotype0.65561420
142MP0002092_abnormal_eye_morphology0.64960287
143MP0000428_abnormal_craniofacial_morphol0.64922236
144MP0008932_abnormal_embryonic_tissue0.64902948
145MP0005670_abnormal_white_adipose0.64248916
146MP0009785_altered_susceptibility_to0.64057174
147MP0002063_abnormal_learning/memory/cond0.63749656
148MP0004742_abnormal_vestibular_system0.63402054
149MP0001286_abnormal_eye_development0.63312960
150MP0003111_abnormal_nucleus_morphology0.63276742
151MP0003724_increased_susceptibility_to0.63163353
152MP0003755_abnormal_palate_morphology0.62995293
153MP0001905_abnormal_dopamine_level0.62938879
154MP0000350_abnormal_cell_proliferation0.62915350
155MP0009250_abnormal_appendicular_skeleto0.62465127
156MP0008438_abnormal_cutaneous_collagen0.61853762
157MP0005187_abnormal_penis_morphology0.61448100
158MP0009384_cardiac_valve_regurgitation0.59993566
159MP0000266_abnormal_heart_morphology0.59814936
160MP0002115_abnormal_skeleton_extremities0.59489993
161MP0009703_decreased_birth_body0.57696674
162MP0005275_abnormal_skin_tensile0.57413594
163MP0000163_abnormal_cartilage_morphology0.56298787
164MP0002210_abnormal_sex_determination0.56281383

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fetal cardiovascular system (HP:0010948)5.74119653
2Abnormal umbilical cord blood vessels (HP:0011403)5.74119653
3Single umbilical artery (HP:0001195)5.74119653
4Anal stenosis (HP:0002025)4.91836649
5Oligodactyly (hands) (HP:0001180)4.23749662
6Short middle phalanx of the 5th finger (HP:0004220)4.20966479
7Bifid tongue (HP:0010297)4.06971600
8Septo-optic dysplasia (HP:0100842)3.94050472
9Congenital malformation of the right heart (HP:0011723)3.91399823
10Double outlet right ventricle (HP:0001719)3.91399823
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.90285220
12Abnormality of the umbilical cord (HP:0010881)3.81133459
13Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)3.80657039
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.73251842
15Abnormality of the parathyroid morphology (HP:0011766)3.72869012
16Labial hypoplasia (HP:0000066)3.51074243
17Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)3.44573703
18Hypoplastic female external genitalia (HP:0012815)3.36594808
19Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.34391224
20Absent radius (HP:0003974)3.25936219
21Anophthalmia (HP:0000528)3.21210729
22Abdominal situs inversus (HP:0003363)3.19956782
23Abnormality of abdominal situs (HP:0011620)3.19956782
24Focal motor seizures (HP:0011153)3.19788973
25Aplasia/hypoplasia of the humerus (HP:0006507)3.12946243
26Short humerus (HP:0005792)3.11907264
27Chromsome breakage (HP:0040012)3.11261120
28Aqueductal stenosis (HP:0002410)3.10915135
29Hypoplastic pelvis (HP:0008839)3.09974023
30Abnormality of the phalanges of the 5th finger (HP:0004213)3.06767351
31Aplasia involving forearm bones (HP:0009822)3.06175979
32Absent forearm bone (HP:0003953)3.06175979
33Optic nerve hypoplasia (HP:0000609)3.05102309
34Mesomelia (HP:0003027)3.04247506
35Nuclear cataract (HP:0100018)3.03589199
36Febrile seizures (HP:0002373)3.03018497
37Absent/shortened dynein arms (HP:0200106)2.96545155
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.96545155
39Progressive inability to walk (HP:0002505)2.95942164
40True hermaphroditism (HP:0010459)2.93649088
41Rectovaginal fistula (HP:0000143)2.93464574
42Rectal fistula (HP:0100590)2.93464574
43Gonadal dysgenesis (HP:0000133)2.92656926
44Chin dimple (HP:0010751)2.88150023
45Abnormal ciliary motility (HP:0012262)2.82774166
46Myelomeningocele (HP:0002475)2.81274618
47Esophageal atresia (HP:0002032)2.79597335
48Gonadotropin excess (HP:0000837)2.76949850
49Abnormal hair whorl (HP:0010721)2.75607961
50Aplasia cutis congenita (HP:0001057)2.75149629
51Oligodactyly (HP:0012165)2.70901889
52Supernumerary spleens (HP:0009799)2.65973059
53Anal atresia (HP:0002023)2.61851906
54Osteomalacia (HP:0002749)2.55474844
55Abnormal respiratory epithelium morphology (HP:0012253)2.54028964
56Abnormal respiratory motile cilium morphology (HP:0005938)2.54028964
57Hemivertebrae (HP:0002937)2.51922864
58Volvulus (HP:0002580)2.50435608
59Abnormal lung lobation (HP:0002101)2.49953516
603-Methylglutaconic aciduria (HP:0003535)2.49590112
61Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.48836580
62Ectopic anus (HP:0004397)2.47154481
63Abnormalities of placenta or umbilical cord (HP:0001194)2.45754272
64Preaxial foot polydactyly (HP:0001841)2.45347099
65Pancreatic fibrosis (HP:0100732)2.45295376
66Vaginal fistula (HP:0004320)2.43315586
67Intestinal fistula (HP:0100819)2.42042431
68Abnormality of incisor morphology (HP:0011063)2.35429790
69Chronic hepatic failure (HP:0100626)2.35204845
70Tubulointerstitial nephritis (HP:0001970)2.32608544
71Preaxial hand polydactyly (HP:0001177)2.32158312
72Alveolar cell carcinoma (HP:0006519)2.31512406
73Gastrointestinal atresia (HP:0002589)2.30092017
74Abnormality of the labia (HP:0000058)2.28137970
75Mediastinal lymphadenopathy (HP:0100721)2.27720727
76Broad-based gait (HP:0002136)2.27251435
77Duplicated collecting system (HP:0000081)2.26869354
78Mixed hearing impairment (HP:0000410)2.26639111
79Abnormal vertebral ossification (HP:0100569)2.26572284
80Anomalous pulmonary venous return (HP:0010772)2.25707323
81Aplasia/Hypoplasia of the spleen (HP:0010451)2.23337416
82Hyperventilation (HP:0002883)2.22959968
83Hypothermia (HP:0002045)2.22432749
84Abnormality of the renal collecting system (HP:0004742)2.21758366
85Hypoplastic labia majora (HP:0000059)2.21507962
86Missing ribs (HP:0000921)2.18405188
87Cortical dysplasia (HP:0002539)2.16874402
88Pulmonary artery stenosis (HP:0004415)2.16042588
89Horseshoe kidney (HP:0000085)2.15047589
90Type I transferrin isoform profile (HP:0003642)2.14640762
91Abnormal respiratory motile cilium physiology (HP:0012261)2.13761657
92Deep palmar crease (HP:0006191)2.12658688
93Fair hair (HP:0002286)2.11661888
94Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.10241019
95Morphological abnormality of the middle ear (HP:0008609)2.08246182
96Medial flaring of the eyebrow (HP:0010747)2.07843608
97Transposition of the great arteries (HP:0001669)2.07359778
98Abnormal connection of the cardiac segments (HP:0011545)2.07359778
99Abnormal ventriculo-arterial connection (HP:0011563)2.07359778
100Hypoplastic heart (HP:0001961)2.06872637
101Prostate neoplasm (HP:0100787)2.04468258
102Absent septum pellucidum (HP:0001331)2.04303518
103Abnormality of the nasal septum (HP:0000419)2.01598408
104Parakeratosis (HP:0001036)2.01571087
105Occipital encephalocele (HP:0002085)2.01365941
106Stomach cancer (HP:0012126)2.01105710
107Renal dysplasia (HP:0000110)1.99257188
108Abnormality of the pulmonary veins (HP:0011718)1.99099564
109Short hallux (HP:0010109)1.99066375
110Meckel diverticulum (HP:0002245)1.98974487
111Hypoplastic left heart (HP:0004383)1.98666321
112Intestinal atresia (HP:0011100)1.98569581
113Abnormality of the labia majora (HP:0012881)1.98263238
114Ectopic kidney (HP:0000086)1.96165117
115Abnormality of the pubic bones (HP:0003172)1.96133271
116White forelock (HP:0002211)1.95994677
117Epileptic encephalopathy (HP:0200134)1.95853642
118Nephrogenic diabetes insipidus (HP:0009806)1.95681925
119Abnormality of chromosome stability (HP:0003220)1.95666101
120Abnormality of the duodenum (HP:0002246)1.95655311
121Ureteral duplication (HP:0000073)1.95189934
122Patent foramen ovale (HP:0001655)1.94968891
123Patchy hypopigmentation of hair (HP:0011365)1.94136800
124Aplasia/Hypoplasia of the uvula (HP:0010293)1.92917161
125Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.91968049
126Abnormality of the aortic arch (HP:0012303)1.89722794
127Abnormal pancreas size (HP:0012094)1.89641834
128Clubbing of toes (HP:0100760)1.89570708
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.89483797
130Fetal akinesia sequence (HP:0001989)1.89457413
131Pancreatic cysts (HP:0001737)1.88496438
132Optic nerve coloboma (HP:0000588)1.88416701
133Renal hypoplasia (HP:0000089)1.88389139
134Selective tooth agenesis (HP:0001592)1.86742465
135Nonprogressive disorder (HP:0003680)1.86155421
136Rib fusion (HP:0000902)1.86132273
137Renal cortical cysts (HP:0000803)1.84745090
138Abnormality of the intervertebral disk (HP:0005108)1.84549405
139Facial cleft (HP:0002006)1.84268752
140Abnormality of the septum pellucidum (HP:0007375)1.84129472
141Abnormality of the ileum (HP:0001549)1.84122751
142Abnormality of the right ventricle (HP:0001707)1.83374905
143Neoplasm of the tracheobronchial system (HP:0100552)1.83129635
144Abnormality of the preputium (HP:0100587)1.83037280
145Absent eyebrow (HP:0002223)1.83034082
146Respiratory difficulties (HP:0002880)1.80218304
147Congenital sensorineural hearing impairment (HP:0008527)1.80080201
148Small hand (HP:0200055)1.79926414
149Protruding tongue (HP:0010808)1.79842411
150Postaxial foot polydactyly (HP:0001830)1.79813818
151Proximal placement of thumb (HP:0009623)1.79772767
152Down-sloping shoulders (HP:0200021)1.79205426
153Aplasia/Hypoplasia of the hallux (HP:0008362)1.79177722
154Abnormality of the nasolacrimal system (HP:0000614)1.78825470
155Increased IgM level (HP:0003496)1.78657930
156Preauricular pit (HP:0004467)1.78478364
157Periauricular skin pits (HP:0100277)1.78478364
158Congenital hepatic fibrosis (HP:0002612)1.77940046
159Cleft eyelid (HP:0000625)1.77588041
160Anencephaly (HP:0002323)1.76040592
161Deviation of the thumb (HP:0009603)1.75472011
162Abnormality of the lacrimal duct (HP:0011481)1.75389024
163Recurrent corneal erosions (HP:0000495)1.74162273
164Bifid scrotum (HP:0000048)1.73916899
165Asplenia (HP:0001746)1.73527192
166Renal agenesis (HP:0000104)1.72856722
167Congenital primary aphakia (HP:0007707)1.72027909
168Inability to walk (HP:0002540)1.72010027
169Hydronephrosis (HP:0000126)1.71837094
170Duplication of thumb phalanx (HP:0009942)1.71697647
171Split hand (HP:0001171)1.71688300
172Oligohydramnios (HP:0001562)1.71284033
173Nasolacrimal duct obstruction (HP:0000579)1.71268709
174Aplasia/Hypoplasia of the tongue (HP:0010295)1.70631546
175Triphalangeal thumb (HP:0001199)1.70293369
176Reduced antithrombin III activity (HP:0001976)1.70237800
177Bile duct proliferation (HP:0001408)1.69630790
178Abnormal biliary tract physiology (HP:0012439)1.69630790
179Pulmonic stenosis (HP:0001642)1.64248656
180Abnormality of the distal phalanges of the toes (HP:0010182)1.63762739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B6.10289598
2CASK5.67799769
3TRIM283.69454359
4MKNK23.09841510
5YES12.59384082
6ZAK2.42208323
7TNIK2.36408033
8WEE12.34525265
9PNCK2.29499309
10PDK22.29144698
11MAP2K72.17730512
12NEK12.16554023
13PRPF4B2.16006507
14MKNK12.14935094
15TGFBR12.13693709
16SIK32.11870564
17TXK1.92682724
18INSRR1.88587570
19ADRBK21.87167117
20BMPR1B1.81531373
21VRK11.80849394
22MAP3K141.77138591
23EIF2AK31.73747139
24STK101.73365786
25STK161.68674906
26NTRK31.60470400
27MUSK1.60436157
28IRAK31.49719946
29NEK61.48549738
30BMPR21.47856140
31EIF2AK21.45372849
32MAP3K121.41488817
33PLK41.41480550
34SRPK11.41055217
35AKT31.40773094
36MAPK131.37915732
37IRAK41.37890738
38CCNB11.35455084
39EPHA41.35125691
40TTK1.32091155
41MAP3K91.31648851
42CDK81.31635242
43BRSK21.29545977
44PLK21.28475429
45PKN21.26184052
46GRK11.22514024
47BRD41.19972826
48CDK31.14614711
49STK241.14237574
50SGK21.13650180
51STK38L1.08456657
52FLT31.06243160
53MELK1.05567134
54TAOK21.03873090
55TIE11.02225458
56BCR0.91527635
57DYRK20.88571341
58GRK70.88564999
59BLK0.87330387
60TEC0.86907876
61SGK2230.86005356
62SGK4940.86005356
63PRKCE0.84362331
64BRAF0.83947168
65IRAK10.83729339
66UHMK10.82642401
67EPHA20.78913332
68EPHB20.78644495
69MAP4K20.77456629
70CLK10.76867766
71TGFBR20.74049546
72EIF2AK10.73349889
73RIPK40.72852097
74TAF10.72348685
75PIM20.70261725
76IRAK20.69844087
77ERBB30.69842150
78FGFR10.69560360
79DAPK20.68969588
80PLK10.68424200
81PRKD30.67021881
82CDC70.66428700
83MARK10.65296760
84LATS20.64246049
85MST40.63499228
86DMPK0.61522960
87PLK30.61443816
88BRSK10.61321585
89PINK10.60857910
90MAP3K80.59744818
91MAPK70.58894826
92PIK3CA0.56791796
93IKBKB0.56240040
94ERBB40.56067441
95DAPK10.54525244
96ADRBK10.54512778
97CAMK2A0.54327968
98LRRK20.52795148
99NUAK10.51749087
100LYN0.48989933
101TSSK60.48960621
102PBK0.47711515
103CHUK0.47027712
104MYLK0.45092996
105ROCK20.44474580
106FES0.44251515
107FRK0.43848543
108CAMK2B0.43033030
109MAP3K40.42775758
110STK30.42701465
111CHEK20.39518832
112NEK20.38969891
113OBSCN0.37906209
114CAMK10.37890145
115NME10.37880752
116TNK20.36302496
117SGK30.36302235
118CSNK1G10.36018673
119TRPM70.35343170
120PRKCG0.35313785
121CDK190.34943563
122PKN10.34541419
123NLK0.34408412
124MINK10.34067480
125WNK30.33883718
126PRKACA0.33246629
127BUB10.32407277
128SGK10.31455329
129ATR0.31382982
130SIK20.31350189
131PRKCQ0.31249412
132BTK0.31241495
133CAMK40.30772147
134RPS6KB10.30580482
135OXSR10.30545354
136MATK0.29735888
137CDK70.29178789
138VRK20.28676241
139ROCK10.28457848
140STK390.28086738
141ATM0.28058715
142DYRK30.27689100
143PRKG10.27447583
144CHEK10.23224387
145STK40.22202993
146MAP2K10.22000847
147LATS10.19223267
148CSNK2A10.15717391
149WNK40.14608008
150KSR10.14595489
151CAMK1G0.14533302
152AURKB0.13736877
153CDK180.13058816
154CDK40.12194398
155CSNK1G20.11167973
156PAK10.10939576

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.91601407
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.33183422
3Nicotine addiction_Homo sapiens_hsa050333.14083654
4Propanoate metabolism_Homo sapiens_hsa006402.97230351
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.71503458
6Pyruvate metabolism_Homo sapiens_hsa006202.53318103
7Fanconi anemia pathway_Homo sapiens_hsa034602.37171368
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.37061013
9Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20354656
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15817190
11Fatty acid metabolism_Homo sapiens_hsa012122.14705768
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.96064819
13Butanoate metabolism_Homo sapiens_hsa006501.90555534
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.89778743
15Homologous recombination_Homo sapiens_hsa034401.80312024
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78033811
17RNA polymerase_Homo sapiens_hsa030201.73668918
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.68525154
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.66403247
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.65380158
21Basal transcription factors_Homo sapiens_hsa030221.64105288
22RNA transport_Homo sapiens_hsa030131.63430901
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62014275
24Hedgehog signaling pathway_Homo sapiens_hsa043401.59896033
25Autoimmune thyroid disease_Homo sapiens_hsa053201.58139692
26Phototransduction_Homo sapiens_hsa047441.57656794
27Allograft rejection_Homo sapiens_hsa053301.56809475
28Morphine addiction_Homo sapiens_hsa050321.55206664
29Mismatch repair_Homo sapiens_hsa034301.52594968
30Fatty acid degradation_Homo sapiens_hsa000711.51735268
31Cell cycle_Homo sapiens_hsa041101.51282438
32One carbon pool by folate_Homo sapiens_hsa006701.50965410
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.50963792
34Oxidative phosphorylation_Homo sapiens_hsa001901.48822510
35Graft-versus-host disease_Homo sapiens_hsa053321.46956709
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.44101836
37Rheumatoid arthritis_Homo sapiens_hsa053231.43285882
38Taste transduction_Homo sapiens_hsa047421.42338704
39Hippo signaling pathway_Homo sapiens_hsa043901.42283834
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41712911
41Fatty acid elongation_Homo sapiens_hsa000621.38350494
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.37500146
43Ribosome_Homo sapiens_hsa030101.34618135
44Collecting duct acid secretion_Homo sapiens_hsa049661.32428535
45Pyrimidine metabolism_Homo sapiens_hsa002401.32308603
46Serotonergic synapse_Homo sapiens_hsa047261.28575887
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.27975098
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.24457651
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.22568752
50Proteasome_Homo sapiens_hsa030501.22187607
51Spliceosome_Homo sapiens_hsa030401.20737207
52Arachidonic acid metabolism_Homo sapiens_hsa005901.19618243
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.19018774
54Base excision repair_Homo sapiens_hsa034101.17362184
55Purine metabolism_Homo sapiens_hsa002301.16928725
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.16638776
57SNARE interactions in vesicular transport_Homo sapiens_hsa041301.16181544
58Peroxisome_Homo sapiens_hsa041461.14305258
59Type I diabetes mellitus_Homo sapiens_hsa049401.10061637
60Synaptic vesicle cycle_Homo sapiens_hsa047211.09521682
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08133680
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.04785306
63Glutamatergic synapse_Homo sapiens_hsa047241.04507432
64Phagosome_Homo sapiens_hsa041451.04240931
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02870969
66Protein export_Homo sapiens_hsa030601.02592375
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01807689
68Circadian entrainment_Homo sapiens_hsa047131.00885688
69RNA degradation_Homo sapiens_hsa030180.99463149
70Nucleotide excision repair_Homo sapiens_hsa034200.98603025
71Huntingtons disease_Homo sapiens_hsa050160.98168178
72DNA replication_Homo sapiens_hsa030300.96323259
73Melanoma_Homo sapiens_hsa052180.96144035
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91266006
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90391372
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88788041
77Herpes simplex infection_Homo sapiens_hsa051680.85417134
78GABAergic synapse_Homo sapiens_hsa047270.84039997
79Measles_Homo sapiens_hsa051620.82994839
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82898137
81Vibrio cholerae infection_Homo sapiens_hsa051100.82770762
82Olfactory transduction_Homo sapiens_hsa047400.82297610
83Glutathione metabolism_Homo sapiens_hsa004800.81599404
84Basal cell carcinoma_Homo sapiens_hsa052170.81483412
85Asthma_Homo sapiens_hsa053100.79376319
86Parkinsons disease_Homo sapiens_hsa050120.79175068
87Non-homologous end-joining_Homo sapiens_hsa034500.78018247
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.76310256
89p53 signaling pathway_Homo sapiens_hsa041150.75589549
90Alzheimers disease_Homo sapiens_hsa050100.75210853
91Calcium signaling pathway_Homo sapiens_hsa040200.74788481
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72822877
93Carbon metabolism_Homo sapiens_hsa012000.72338499
94beta-Alanine metabolism_Homo sapiens_hsa004100.71451613
95African trypanosomiasis_Homo sapiens_hsa051430.71353669
96Other glycan degradation_Homo sapiens_hsa005110.68765983
97Caffeine metabolism_Homo sapiens_hsa002320.68610427
98Melanogenesis_Homo sapiens_hsa049160.68526317
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68442247
100N-Glycan biosynthesis_Homo sapiens_hsa005100.67066390
101Ovarian steroidogenesis_Homo sapiens_hsa049130.66577261
102Axon guidance_Homo sapiens_hsa043600.66404153
103mRNA surveillance pathway_Homo sapiens_hsa030150.66348626
104Oocyte meiosis_Homo sapiens_hsa041140.65551811
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65231923
106Tryptophan metabolism_Homo sapiens_hsa003800.65138075
107Sulfur metabolism_Homo sapiens_hsa009200.62947510
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62550838
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61662987
110Hematopoietic cell lineage_Homo sapiens_hsa046400.61089263
111Colorectal cancer_Homo sapiens_hsa052100.60270160
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.59098043
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57879008
114* Wnt signaling pathway_Homo sapiens_hsa043100.56903432
115Long-term depression_Homo sapiens_hsa047300.56673989
116Sphingolipid metabolism_Homo sapiens_hsa006000.56643012
117Steroid biosynthesis_Homo sapiens_hsa001000.56048610
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.55095043
119Vitamin digestion and absorption_Homo sapiens_hsa049770.53518060
120Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52297415
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52075740
122Influenza A_Homo sapiens_hsa051640.51916817
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51449626
124Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49420367
125Proteoglycans in cancer_Homo sapiens_hsa052050.49244421
126Retinol metabolism_Homo sapiens_hsa008300.48876140
127Regulation of autophagy_Homo sapiens_hsa041400.48660717
128Ras signaling pathway_Homo sapiens_hsa040140.48185968
129Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47854954
130Transcriptional misregulation in cancer_Homo sapiens_hsa052020.47587266
131Insulin secretion_Homo sapiens_hsa049110.47055861
132Biosynthesis of amino acids_Homo sapiens_hsa012300.46817299
133PPAR signaling pathway_Homo sapiens_hsa033200.45409350
134Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43931434
135Legionellosis_Homo sapiens_hsa051340.43514697
136Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42513706
137Circadian rhythm_Homo sapiens_hsa047100.41634076
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.41154787
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39994962
140Fat digestion and absorption_Homo sapiens_hsa049750.39939172
141Metabolic pathways_Homo sapiens_hsa011000.38834719
142Primary immunodeficiency_Homo sapiens_hsa053400.37805541
143Rap1 signaling pathway_Homo sapiens_hsa040150.37004975
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.34648924
145Adherens junction_Homo sapiens_hsa045200.33872257
146Tight junction_Homo sapiens_hsa045300.33868137
147Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33852729
148TGF-beta signaling pathway_Homo sapiens_hsa043500.33430062
149Cholinergic synapse_Homo sapiens_hsa047250.33293703
150Protein digestion and absorption_Homo sapiens_hsa049740.32821010
151Folate biosynthesis_Homo sapiens_hsa007900.32664982
152Selenocompound metabolism_Homo sapiens_hsa004500.32558975
153Chemical carcinogenesis_Homo sapiens_hsa052040.29767886
154cAMP signaling pathway_Homo sapiens_hsa040240.26303366
155Pathways in cancer_Homo sapiens_hsa052000.20795396
156Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.19549094
157Gastric acid secretion_Homo sapiens_hsa049710.18092356
158Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.17282525
159Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17217398

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