CEP83

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a centriolar protein involved in primary cilium assembly. Defects in this gene have been associated with infantile nephronophthisis and intellectual disability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.36880246
2mitotic sister chromatid cohesion (GO:0007064)5.25310958
3nuclear pore organization (GO:0006999)4.96510757
4cilium or flagellum-dependent cell motility (GO:0001539)4.72378860
5kinetochore organization (GO:0051383)4.59878432
6synapsis (GO:0007129)4.48406327
7protein localization to chromosome, centromeric region (GO:0071459)4.42544870
8pore complex assembly (GO:0046931)4.25675409
9protein localization to kinetochore (GO:0034501)4.24500329
10mitotic metaphase plate congression (GO:0007080)4.15651917
11DNA double-strand break processing (GO:0000729)4.15360722
12mitotic chromosome condensation (GO:0007076)4.11763030
13replication fork processing (GO:0031297)4.10656554
14axonemal dynein complex assembly (GO:0070286)4.02943418
15microtubule depolymerization (GO:0007019)3.95744528
16attachment of spindle microtubules to kinetochore (GO:0008608)3.93950199
17regulation of centriole replication (GO:0046599)3.93386142
18meiotic chromosome segregation (GO:0045132)3.91396074
19piRNA metabolic process (GO:0034587)3.84262267
20metaphase plate congression (GO:0051310)3.83741057
21acrosome assembly (GO:0001675)3.82057409
22establishment of chromosome localization (GO:0051303)3.79524782
23sperm-egg recognition (GO:0035036)3.79223577
24histone exchange (GO:0043486)3.78297990
25fusion of sperm to egg plasma membrane (GO:0007342)3.77603621
26epithelial cilium movement (GO:0003351)3.76390182
27intraciliary transport (GO:0042073)3.74818874
28kinetochore assembly (GO:0051382)3.74655705
29DNA replication initiation (GO:0006270)3.72136652
30mitotic sister chromatid segregation (GO:0000070)3.71606979
31binding of sperm to zona pellucida (GO:0007339)3.71472694
32sister chromatid segregation (GO:0000819)3.70620978
33male meiosis (GO:0007140)3.69820729
34resolution of meiotic recombination intermediates (GO:0000712)3.69429743
35chromatin remodeling at centromere (GO:0031055)3.67718501
36axoneme assembly (GO:0035082)3.67196969
37chromosome condensation (GO:0030261)3.65846334
38mitotic nuclear envelope disassembly (GO:0007077)3.63046998
39sister chromatid cohesion (GO:0007062)3.63014301
40monoubiquitinated protein deubiquitination (GO:0035520)3.62520770
41DNA unwinding involved in DNA replication (GO:0006268)3.60840205
42DNA packaging (GO:0006323)3.57295804
43CENP-A containing nucleosome assembly (GO:0034080)3.55623361
44regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.52888787
45cell wall macromolecule metabolic process (GO:0044036)3.52635750
46cell wall macromolecule catabolic process (GO:0016998)3.52635750
47synaptonemal complex assembly (GO:0007130)3.50789174
48motile cilium assembly (GO:0044458)3.49248936
49protein localization to chromosome (GO:0034502)3.48901492
50regulation of cilium movement (GO:0003352)3.48104066
51double-strand break repair via homologous recombination (GO:0000724)3.47797660
52DNA replication-independent nucleosome organization (GO:0034724)3.46599604
53DNA replication-independent nucleosome assembly (GO:0006336)3.46599604
54recombinational repair (GO:0000725)3.46485967
55regulation of DNA endoreduplication (GO:0032875)3.44540978
56synaptonemal complex organization (GO:0070193)3.44095954
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.43018443
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.43018443
59positive regulation of mitotic sister chromatid separation (GO:1901970)3.43018443
60regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42747159
61regulation of mitotic spindle checkpoint (GO:1903504)3.42747159
62DNA replication checkpoint (GO:0000076)3.42072478
63membrane disassembly (GO:0030397)3.41297955
64nuclear envelope disassembly (GO:0051081)3.41297955
65cell-cell recognition (GO:0009988)3.41078118
66reciprocal DNA recombination (GO:0035825)3.41059816
67reciprocal meiotic recombination (GO:0007131)3.41059816
68sperm motility (GO:0030317)3.39377730
69regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38963714
70cilium movement (GO:0003341)3.35164390
71epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30482974
72regulation of histone H3-K9 methylation (GO:0051570)3.28992644
73regulation of centrosome cycle (GO:0046605)3.28345116
74protein K6-linked ubiquitination (GO:0085020)3.28106949
75DNA strand elongation involved in DNA replication (GO:0006271)3.27761585
76regulation of meiosis I (GO:0060631)3.24197522
77chromosome organization involved in meiosis (GO:0070192)3.23466877
78multicellular organism reproduction (GO:0032504)3.22442826
79* cilium organization (GO:0044782)3.22136741
80telomere maintenance via recombination (GO:0000722)3.22093103
81spermatid development (GO:0007286)3.21171672
82DNA replication-dependent nucleosome organization (GO:0034723)3.20802356
83DNA replication-dependent nucleosome assembly (GO:0006335)3.20802356
84mitotic recombination (GO:0006312)3.19885203
85chromatin assembly or disassembly (GO:0006333)3.19690287
86maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.18182207
87meiotic nuclear division (GO:0007126)3.17307162
88regulation of sister chromatid cohesion (GO:0007063)3.16229766
89translesion synthesis (GO:0019985)3.15032401
90regulation of chromosome segregation (GO:0051983)3.14723242
91regulation of spindle organization (GO:0090224)3.14155475
92male meiosis I (GO:0007141)3.11371416
93DNA strand elongation (GO:0022616)3.09403074
94* cilium assembly (GO:0042384)3.08899687
95DNA conformation change (GO:0071103)3.08559425
96telomere maintenance via semi-conservative replication (GO:0032201)3.07557041
97centriole replication (GO:0007099)3.04784364
98chromosome segregation (GO:0007059)3.02082590
99somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.01727515
100somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.01727515
101isotype switching (GO:0045190)3.01727515
102prenylation (GO:0097354)2.99133651
103protein prenylation (GO:0018342)2.99133651
104ATP-dependent chromatin remodeling (GO:0043044)2.98912354
105gene silencing by RNA (GO:0031047)2.98636542
106histone H2A acetylation (GO:0043968)2.97597249
107DNA geometric change (GO:0032392)2.96711581
108cilium morphogenesis (GO:0060271)2.96337601
109negative regulation of DNA-dependent DNA replication (GO:2000104)2.95515440
110positive regulation of histone H3-K4 methylation (GO:0051571)2.95043909
111somatic diversification of immune receptors via somatic mutation (GO:0002566)2.94659156
112somatic hypermutation of immunoglobulin genes (GO:0016446)2.94659156
113DNA duplex unwinding (GO:0032508)2.94247253
114regulation of mitotic metaphase/anaphase transition (GO:0030071)2.94140780
115positive regulation of chromosome segregation (GO:0051984)2.93208292
116left/right axis specification (GO:0070986)2.91722448
117meiotic cell cycle (GO:0051321)2.91375629
118RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90798081
119heterochromatin organization (GO:0070828)2.90326431
120regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90214813
121spindle checkpoint (GO:0031577)2.90157341
122neural tube formation (GO:0001841)2.89106844
123regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.88569648
124chromosome organization (GO:0051276)2.87046968
125regulation of centrosome duplication (GO:0010824)2.86000872
126chromatin assembly (GO:0031497)2.82030179
127DNA ligation (GO:0006266)2.81732834
128intra-S DNA damage checkpoint (GO:0031573)2.81336353
129regulation of RNA export from nucleus (GO:0046831)2.79424105
130centriole assembly (GO:0098534)2.78752255
131regulation of mitotic sister chromatid segregation (GO:0033047)2.78390266
132histone mRNA metabolic process (GO:0008334)2.77407687
133somatic diversification of immunoglobulins (GO:0016445)2.74584706
134rRNA catabolic process (GO:0016075)2.74204254
135double-strand break repair via nonhomologous end joining (GO:0006303)2.73973763
136non-recombinational repair (GO:0000726)2.73973763
137organelle disassembly (GO:1903008)2.73032495
138DNA methylation involved in gamete generation (GO:0043046)2.71065658
139DNA catabolic process, exonucleolytic (GO:0000738)2.70952891
140postreplication repair (GO:0006301)2.70454666
141somatic recombination of immunoglobulin gene segments (GO:0016447)2.69196805
142centrosome organization (GO:0051297)2.69005754
143double-strand break repair (GO:0006302)2.68808496
144microtubule anchoring (GO:0034453)2.66381894
145microtubule polymerization or depolymerization (GO:0031109)2.63076253
146regulation of nuclear cell cycle DNA replication (GO:0033262)2.62752511
147microtubule organizing center organization (GO:0031023)2.62691114
148DNA recombination (GO:0006310)2.62457259
149meiosis I (GO:0007127)2.61171171
150negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.60024655
151negative regulation of translation, ncRNA-mediated (GO:0040033)2.60024655
152regulation of translation, ncRNA-mediated (GO:0045974)2.60024655
153meiotic cell cycle process (GO:1903046)2.59938484
154protein localization to cilium (GO:0061512)2.56790640
155mitotic G2/M transition checkpoint (GO:0044818)2.53739193
156protein K11-linked deubiquitination (GO:0035871)2.53574622
157proteasome assembly (GO:0043248)2.53090291
158nonmotile primary cilium assembly (GO:0035058)2.51546622
159pseudouridine synthesis (GO:0001522)2.51461046
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.50511799
161mismatch repair (GO:0006298)2.50074237

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.88720471
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.93517056
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.75303538
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.58439256
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.05968593
6ZNF274_21170338_ChIP-Seq_K562_Hela3.00181905
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.84304850
8VDR_22108803_ChIP-Seq_LS180_Human2.80567447
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.74858423
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63704278
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.57242098
12AR_21909140_ChIP-Seq_LNCAP_Human2.56764486
13IGF1R_20145208_ChIP-Seq_DFB_Human2.41592859
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32618046
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.23289258
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18157199
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.16733998
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07298522
19E2F7_22180533_ChIP-Seq_HELA_Human11.1157157
20TAF15_26573619_Chip-Seq_HEK293_Human1.99474207
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97711088
22CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.97251449
23ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90221881
24MYC_19030024_ChIP-ChIP_MESCs_Mouse1.87123201
25MYC_19079543_ChIP-ChIP_MESCs_Mouse1.85423132
26P300_19829295_ChIP-Seq_ESCs_Human1.84755759
27CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.84642888
28ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79625755
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.76708950
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.76656935
31GBX2_23144817_ChIP-Seq_PC3_Human1.76244467
32SALL1_21062744_ChIP-ChIP_HESCs_Human1.75581898
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73501567
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70748100
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70076240
36VDR_23849224_ChIP-Seq_CD4+_Human1.65993482
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.65865629
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65511728
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57494558
40ELK1_19687146_ChIP-ChIP_HELA_Human1.57020906
41ER_23166858_ChIP-Seq_MCF-7_Human1.56649645
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56646129
43IRF1_19129219_ChIP-ChIP_H3396_Human1.55629996
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53662440
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48300711
46CBP_20019798_ChIP-Seq_JUKART_Human1.48034906
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48034906
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45873138
49FOXP3_21729870_ChIP-Seq_TREG_Human1.43026920
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.42493470
51MYC_22102868_ChIP-Seq_BL_Human1.40335282
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39916673
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.39483752
54MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36874561
55SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36616123
56POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34981568
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.34857775
58SMAD4_21799915_ChIP-Seq_A2780_Human1.34307782
59STAT3_23295773_ChIP-Seq_U87_Human1.33537674
60DCP1A_22483619_ChIP-Seq_HELA_Human1.33441698
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.29096896
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.26351214
63CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26279627
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26220394
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25810663
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24802610
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24335567
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.23123157
69PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22660586
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22035052
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21929964
72XRN2_22483619_ChIP-Seq_HELA_Human1.21442950
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20596148
74BCAT_22108803_ChIP-Seq_LS180_Human1.20089220
75TTF2_22483619_ChIP-Seq_HELA_Human1.19554912
76STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19358119
77TCF4_23295773_ChIP-Seq_U87_Human1.19270497
78MYB_26560356_Chip-Seq_TH2_Human1.19034246
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19012988
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.18316864
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18209242
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.17599066
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17291579
84NFE2_27457419_Chip-Seq_LIVER_Mouse1.17289087
85TP53_22573176_ChIP-Seq_HFKS_Human1.17147931
86ETS1_20019798_ChIP-Seq_JURKAT_Human1.16990531
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.15996795
88RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.15665144
89MYB_26560356_Chip-Seq_TH1_Human1.14764461
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.14531739
91TCF4_22108803_ChIP-Seq_LS180_Human1.14502170
92KDM5A_27292631_Chip-Seq_BREAST_Human1.13003477
93SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12989541
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12476652
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11938010
96NANOG_18555785_Chip-Seq_ESCs_Mouse1.10701891
97PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10608434
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.10439764
99SOX2_19829295_ChIP-Seq_ESCs_Human1.10402206
100NANOG_19829295_ChIP-Seq_ESCs_Human1.10402206
101SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09789709
102TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09142220
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.08996696
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08550680
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08406609
106FUS_26573619_Chip-Seq_HEK293_Human1.07985023
107FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07713447
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.06318845
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.06318845
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06200830
111AR_25329375_ChIP-Seq_VCAP_Human1.05891491
112SRF_21415370_ChIP-Seq_HL-1_Mouse1.05646059
113GABP_19822575_ChIP-Seq_HepG2_Human1.05515015
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05180632
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05180632
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04384857
117GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01777407
118SPI1_23547873_ChIP-Seq_NB4_Human1.01439146
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01282351
120FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00729842
121SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.00231439
122RUNX2_22187159_ChIP-Seq_PCA_Human1.00200085
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00092026
124IRF8_21731497_ChIP-ChIP_J774_Mouse0.99923872
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.99696219
126ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97998891
127CDX2_22108803_ChIP-Seq_LS180_Human0.97115558
128P53_22387025_ChIP-Seq_ESCs_Mouse0.97011688
129CIITA_25753668_ChIP-Seq_RAJI_Human0.95619323
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95251576
131FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.94269680
132PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91730246
133ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.91675110
134HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91285245
135MYC_18940864_ChIP-ChIP_HL60_Human0.90008319
136ERG_20887958_ChIP-Seq_HPC-7_Mouse0.87780342
137KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87232833
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87229973
139JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85609804
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85037291
141HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84416001
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83940126
143STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83621802
144FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.81848911
145EWS_26573619_Chip-Seq_HEK293_Human0.79623796
146ELF1_17652178_ChIP-ChIP_JURKAT_Human0.79540905
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79381011
148BRD4_27068464_Chip-Seq_AML-cells_Mouse0.77507357
149IRF8_22096565_ChIP-ChIP_GC-B_Human0.76165243
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.75917498
151STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.75571855
152MAF_26560356_Chip-Seq_TH1_Human0.71835916
153PU_27001747_Chip-Seq_BMDM_Mouse0.71257400
154FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.70156735
155TCF7_22412390_ChIP-Seq_EML_Mouse0.69702449
156MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.68594126
157E2F1_18555785_ChIP-Seq_MESCs_Mouse0.67767784
158RUNX1_22412390_ChIP-Seq_EML_Mouse0.66376795
159TFEB_21752829_ChIP-Seq_HELA_Human0.65195008
160IRF8_27001747_Chip-Seq_BMDM_Mouse0.64878925
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.64785838
162CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.64215821
163UTX_26944678_Chip-Seq_JUKART_Human0.63379339
164ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.62480234
165PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.61946360

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.41273819
2MP0008877_abnormal_DNA_methylation4.06385654
3MP0003693_abnormal_embryo_hatching3.90292412
4MP0003111_abnormal_nucleus_morphology3.88443413
5MP0005410_abnormal_fertilization3.84722193
6MP0008057_abnormal_DNA_replication3.60166770
7MP0003077_abnormal_cell_cycle3.33057443
8MP0004957_abnormal_blastocyst_morpholog3.11388014
9MP0008058_abnormal_DNA_repair3.04296588
10MP0010307_abnormal_tumor_latency2.89577207
11MP0002396_abnormal_hematopoietic_system2.47725017
12MP0008007_abnormal_cellular_replicative2.42112822
13MP0001929_abnormal_gametogenesis2.37768873
14MP0010352_gastrointestinal_tract_polyps2.32563380
15MP0003718_maternal_effect2.31232680
16MP0004808_abnormal_hematopoietic_stem2.19961155
17MP0003136_yellow_coat_color2.12552578
18MP0000569_abnormal_digit_pigmentation2.09811577
19MP0003123_paternal_imprinting2.07771683
20MP0002210_abnormal_sex_determination2.03232112
21MP0006072_abnormal_retinal_apoptosis2.03069670
22MP0003303_peritoneal_inflammation2.02743028
23MP0003698_abnormal_male_reproductive1.98003486
24MP0008932_abnormal_embryonic_tissue1.91959539
25MP0002938_white_spotting1.90572519
26MP0000350_abnormal_cell_proliferation1.83076723
27MP0005551_abnormal_eye_electrophysiolog1.80286364
28MP0005076_abnormal_cell_differentiation1.79602171
29MP0002653_abnormal_ependyma_morphology1.77263796
30MP0000372_irregular_coat_pigmentation1.77239907
31MP0001730_embryonic_growth_arrest1.75845133
32MP0003787_abnormal_imprinting1.74489679
33MP0008789_abnormal_olfactory_epithelium1.68954883
34MP0000383_abnormal_hair_follicle1.67693504
35MP0001145_abnormal_male_reproductive1.65644377
36MP0005397_hematopoietic_system_phenotyp1.64081533
37MP0001545_abnormal_hematopoietic_system1.64081533
38MP0003121_genomic_imprinting1.61949336
39MP0005253_abnormal_eye_physiology1.58114357
40MP0002638_abnormal_pupillary_reflex1.55661431
41MP0000427_abnormal_hair_cycle1.53409973
42MP0003786_premature_aging1.52561282
43MP0001984_abnormal_olfaction1.52396138
44MP0003195_calcinosis1.52285423
45MP0000490_abnormal_crypts_of1.50051830
46MP0009697_abnormal_copulation1.47953568
47MP0000653_abnormal_sex_gland1.47759082
48MP0001485_abnormal_pinna_reflex1.45119142
49MP0001672_abnormal_embryogenesis/_devel1.43031860
50MP0005380_embryogenesis_phenotype1.43031860
51MP0001697_abnormal_embryo_size1.39019776
52MP0002837_dystrophic_cardiac_calcinosis1.38238694
53MP0000703_abnormal_thymus_morphology1.38187432
54MP0002398_abnormal_bone_marrow1.37533517
55MP0003763_abnormal_thymus_physiology1.34765841
56MP0004133_heterotaxia1.33147142
57MP0002084_abnormal_developmental_patter1.33007526
58MP0003984_embryonic_growth_retardation1.31310934
59MP0008875_abnormal_xenobiotic_pharmacok1.30365683
60MP0005084_abnormal_gallbladder_morpholo1.27724766
61MP0004197_abnormal_fetal_growth/weight/1.25827877
62MP0002019_abnormal_tumor_incidence1.25351498
63MP0002088_abnormal_embryonic_growth/wei1.25243431
64MP0010678_abnormal_skin_adnexa1.24928189
65MP0002086_abnormal_extraembryonic_tissu1.23654518
66MP0000313_abnormal_cell_death1.23461556
67MP0004043_abnormal_pH_regulation1.22964573
68MP0002080_prenatal_lethality1.20952355
69MP0002085_abnormal_embryonic_tissue1.19548462
70MP0004147_increased_porphyrin_level1.19139388
71MP0002161_abnormal_fertility/fecundity1.17588803
72MP0002928_abnormal_bile_duct1.17063050
73MP0000631_abnormal_neuroendocrine_gland1.16311715
74MP0005171_absent_coat_pigmentation1.13910204
75MP0001835_abnormal_antigen_presentation1.13743366
76MP0006276_abnormal_autonomic_nervous1.12757435
77MP0003890_abnormal_embryonic-extraembry1.11471719
78MP0003567_abnormal_fetal_cardiomyocyte1.10448263
79MP0002160_abnormal_reproductive_system1.09774174
80MP0005623_abnormal_meninges_morphology1.09605885
81MP0005499_abnormal_olfactory_system1.08532250
82MP0005394_taste/olfaction_phenotype1.08532250
83MP0005646_abnormal_pituitary_gland1.07173614
84MP0003943_abnormal_hepatobiliary_system1.07017670
85MP0009278_abnormal_bone_marrow1.06689467
86MP0002736_abnormal_nociception_after1.05543039
87MP0002277_abnormal_respiratory_mucosa1.05087722
88MP0000647_abnormal_sebaceous_gland1.03732437
89MP0002233_abnormal_nose_morphology1.03586724
90MP0005391_vision/eye_phenotype1.01875231
91MP0002876_abnormal_thyroid_physiology1.01873656
92MP0001986_abnormal_taste_sensitivity1.01492274
93MP0004215_abnormal_myocardial_fiber0.99502129
94MP0002722_abnormal_immune_system0.99347883
95MP0005187_abnormal_penis_morphology0.98846180
96MP0003880_abnormal_central_pattern0.98034637
97MP0002006_tumorigenesis0.96460427
98MP0003646_muscle_fatigue0.96210135
99MP0000716_abnormal_immune_system0.95828567
100MP0005395_other_phenotype0.95638546
101MP0001324_abnormal_eye_pigmentation0.95349770
102MP0001529_abnormal_vocalization0.93526787
103MP0000689_abnormal_spleen_morphology0.92600341
104MP0002429_abnormal_blood_cell0.92173101
105MP0002452_abnormal_antigen_presenting0.92041408
106MP0001800_abnormal_humoral_immune0.91757048
107MP0002405_respiratory_system_inflammati0.91731833
108MP0001293_anophthalmia0.91680821
109MP0002095_abnormal_skin_pigmentation0.90911726
110MP0002420_abnormal_adaptive_immunity0.90006202
111MP0001819_abnormal_immune_cell0.89534652
112MP0001286_abnormal_eye_development0.89192314
113MP0002234_abnormal_pharynx_morphology0.88648157
114MP0003950_abnormal_plasma_membrane0.86581325
115MP0002877_abnormal_melanocyte_morpholog0.86413258
116MP0009333_abnormal_splenocyte_physiolog0.84468122
117MP0006292_abnormal_olfactory_placode0.84188615
118MP0003448_altered_tumor_morphology0.83459572
119MP0004142_abnormal_muscle_tone0.82918180
120MP0005075_abnormal_melanosome_morpholog0.82803108
121MP0001915_intracranial_hemorrhage0.82518271
122MP0002723_abnormal_immune_serum0.81741454
123MP0009046_muscle_twitch0.80075280
124MP0001119_abnormal_female_reproductive0.79916722
125MP0008872_abnormal_physiological_respon0.79691916
126MP0000858_altered_metastatic_potential0.79399225
127MP0005671_abnormal_response_to0.78851104
128MP0000432_abnormal_head_morphology0.78841953
129MP0003300_gastrointestinal_ulcer0.76118121
130MP0005195_abnormal_posterior_eye0.75540042
131MP0002751_abnormal_autonomic_nervous0.75413933
132MP0002166_altered_tumor_susceptibility0.75197369
133MP0000685_abnormal_immune_system0.73934722
134MP0003755_abnormal_palate_morphology0.73248601
135MP0002009_preneoplasia0.73131529
136MP0005000_abnormal_immune_tolerance0.73064587
137MP0002102_abnormal_ear_morphology0.72586061
138MP0005174_abnormal_tail_pigmentation0.72573473
139MP0005389_reproductive_system_phenotype0.71814645
140MP0002282_abnormal_trachea_morphology0.71273550
141MP0000428_abnormal_craniofacial_morphol0.71268639
142MP0003937_abnormal_limbs/digits/tail_de0.71238105
143MP0006036_abnormal_mitochondrial_physio0.70530719
144MP0003252_abnormal_bile_duct0.70103574
145MP0005621_abnormal_cell_physiology0.69598809
146MP0006035_abnormal_mitochondrial_morpho0.69353000
147MP0005384_cellular_phenotype0.69116241
148MP0000015_abnormal_ear_pigmentation0.69023354
149MP0000049_abnormal_middle_ear0.67059348
150MP0003936_abnormal_reproductive_system0.66459255
151MP0009785_altered_susceptibility_to0.63860442
152MP0000733_abnormal_muscle_development0.63619665
153MP0002925_abnormal_cardiovascular_devel0.60961716
154MP0001188_hyperpigmentation0.60767752
155MP0005387_immune_system_phenotype0.58151597
156MP0001790_abnormal_immune_system0.58151597
157MP0008995_early_reproductive_senescence0.56259132
158MP0003941_abnormal_skin_development0.56044232
159MP0000358_abnormal_cell_content/0.55771455
160MP0003115_abnormal_respiratory_system0.54869659
161MP0003436_decreased_susceptibility_to0.54370503

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.02404112
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.13431062
3Absent/shortened dynein arms (HP:0200106)5.13431062
4Abnormal respiratory motile cilium physiology (HP:0012261)4.51831195
5Rhinitis (HP:0012384)4.40312699
6Abnormal respiratory epithelium morphology (HP:0012253)4.32489138
7Abnormal respiratory motile cilium morphology (HP:0005938)4.32489138
8Pancreatic cysts (HP:0001737)4.10073388
9Volvulus (HP:0002580)3.93660082
10True hermaphroditism (HP:0010459)3.81825249
11Chromsome breakage (HP:0040012)3.79971587
12Abnormal ciliary motility (HP:0012262)3.66036087
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31549422
14Chronic bronchitis (HP:0004469)3.29803137
15Chronic hepatic failure (HP:0100626)3.10273067
16Abnormality of the renal cortex (HP:0011035)3.04307190
17Medial flaring of the eyebrow (HP:0010747)3.02267335
18Ectopic kidney (HP:0000086)2.92258433
19Abnormality of chromosome stability (HP:0003220)2.90732169
20Bronchiectasis (HP:0002110)2.85128425
21Acute myeloid leukemia (HP:0004808)2.79686570
22Nasal polyposis (HP:0100582)2.72863827
23Cystic liver disease (HP:0006706)2.71403112
24Birth length less than 3rd percentile (HP:0003561)2.68557096
25Aplasia/Hypoplasia of the tongue (HP:0010295)2.68439729
26Impulsivity (HP:0100710)2.68194867
27Renal cortical cysts (HP:0000803)2.62780201
28Bronchitis (HP:0012387)2.57130920
29Infertility (HP:0000789)2.55871793
30* Tubulointerstitial nephritis (HP:0001970)2.51889665
31Meckel diverticulum (HP:0002245)2.51648206
32Postaxial foot polydactyly (HP:0001830)2.50740859
33Myelodysplasia (HP:0002863)2.47670065
34Congenital primary aphakia (HP:0007707)2.47267070
35Abnormality of the fingertips (HP:0001211)2.40418000
36Aplasia/Hypoplasia of the uvula (HP:0010293)2.37135732
37Gait imbalance (HP:0002141)2.35461420
38Increased nuchal translucency (HP:0010880)2.35315169
39Abnormality of the ileum (HP:0001549)2.32867274
40Congenital stationary night blindness (HP:0007642)2.32414606
41Absent frontal sinuses (HP:0002688)2.30362126
42Abnormality of the preputium (HP:0100587)2.29304867
43Nephrogenic diabetes insipidus (HP:0009806)2.29055305
44Nephroblastoma (Wilms tumor) (HP:0002667)2.27730584
45Abnormality of the anterior horn cell (HP:0006802)2.27463641
46Degeneration of anterior horn cells (HP:0002398)2.27463641
47Medulloblastoma (HP:0002885)2.26682849
48Occipital encephalocele (HP:0002085)2.25059326
49Sloping forehead (HP:0000340)2.24928069
50Congenital hepatic fibrosis (HP:0002612)2.24262266
51Sclerocornea (HP:0000647)2.23287296
52Bile duct proliferation (HP:0001408)2.22988005
53Abnormal biliary tract physiology (HP:0012439)2.22988005
54Abnormality of the nasal mucosa (HP:0000433)2.22982366
55High pitched voice (HP:0001620)2.20544426
56* Nephronophthisis (HP:0000090)2.20372014
57Colon cancer (HP:0003003)2.17450719
58Genital tract atresia (HP:0001827)2.17369312
59Papillary thyroid carcinoma (HP:0002895)2.16146563
60Embryonal renal neoplasm (HP:0011794)2.15483890
61Abnormality of the labia minora (HP:0012880)2.15257388
62Abnormal spermatogenesis (HP:0008669)2.14895064
63Preaxial hand polydactyly (HP:0001177)2.13947582
64Papilledema (HP:0001085)2.13502179
65Recurrent sinusitis (HP:0011108)2.11926111
66Abnormality of midbrain morphology (HP:0002418)2.11412680
67Molar tooth sign on MRI (HP:0002419)2.11412680
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.10509503
69Abnormal rod and cone electroretinograms (HP:0008323)2.09243417
70Small intestinal stenosis (HP:0012848)2.08991873
71Duodenal stenosis (HP:0100867)2.08991873
72Recurrent bronchitis (HP:0002837)2.08682774
73Supernumerary spleens (HP:0009799)2.05825583
74Anencephaly (HP:0002323)2.05411106
75Vaginal atresia (HP:0000148)2.04936162
76Male infertility (HP:0003251)2.03752349
77* Tubular atrophy (HP:0000092)2.02719132
78Reticulocytopenia (HP:0001896)2.02481701
79Oculomotor apraxia (HP:0000657)2.02046510
80Abnormality of DNA repair (HP:0003254)2.01839719
81Male pseudohermaphroditism (HP:0000037)2.01536214
82Abolished electroretinogram (ERG) (HP:0000550)1.99842881
83Abnormality of macular pigmentation (HP:0008002)1.99261370
84Gonadotropin excess (HP:0000837)1.99192348
8511 pairs of ribs (HP:0000878)1.94718560
86Poor coordination (HP:0002370)1.94200748
87Optic neuritis (HP:0100653)1.92575227
88Retrobulbar optic neuritis (HP:0100654)1.92575227
89Hypoplasia of the pons (HP:0012110)1.92053048
90Thrombocytosis (HP:0001894)1.91981777
91Agnosia (HP:0010524)1.91561718
92Truncal obesity (HP:0001956)1.91101358
93Prominent nose (HP:0000448)1.90820908
94Aplasia/Hypoplasia of the spleen (HP:0010451)1.90566101
95Glioma (HP:0009733)1.89338462
96Selective tooth agenesis (HP:0001592)1.89337582
97Abnormality of the pons (HP:0007361)1.87999972
98Deviation of the thumb (HP:0009603)1.87683733
99Astigmatism (HP:0000483)1.87463725
100Attenuation of retinal blood vessels (HP:0007843)1.86584174
101Postaxial hand polydactyly (HP:0001162)1.86582603
102Triphalangeal thumb (HP:0001199)1.84337020
103Proximal placement of thumb (HP:0009623)1.83971419
104Asplenia (HP:0001746)1.83936806
105Short 4th metacarpal (HP:0010044)1.82785380
106Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82785380
107Abnormality of the carotid arteries (HP:0005344)1.81170479
108Facial hemangioma (HP:0000329)1.80868408
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80857331
110Subacute progressive viral hepatitis (HP:0006572)1.80159644
111Microglossia (HP:0000171)1.79777508
112Oligodactyly (hands) (HP:0001180)1.78575456
113Patellar aplasia (HP:0006443)1.78251264
114Small hand (HP:0200055)1.77326552
115Absent thumb (HP:0009777)1.76772505
116Aganglionic megacolon (HP:0002251)1.76751686
117Oligohydramnios (HP:0001562)1.75907723
118Pancreatic fibrosis (HP:0100732)1.75599169
119Short tibia (HP:0005736)1.75117636
120Clubbing of toes (HP:0100760)1.74631842
121Intestinal atresia (HP:0011100)1.74098878
122Central scotoma (HP:0000603)1.73116415
123Acute lymphatic leukemia (HP:0006721)1.71741497
124Acute necrotizing encephalopathy (HP:0006965)1.71695837
125Rhabdomyosarcoma (HP:0002859)1.71694121
126Increased CSF lactate (HP:0002490)1.71505150
127Biliary tract neoplasm (HP:0100574)1.71064407
128Deep philtrum (HP:0002002)1.69013049
129Cafe-au-lait spot (HP:0000957)1.68929372
130* Abnormality of the renal medulla (HP:0100957)1.68220625
131Multicystic kidney dysplasia (HP:0000003)1.68126470
132Prominent nasal bridge (HP:0000426)1.67807608
133Myositis (HP:0100614)1.67169257
134Type II lissencephaly (HP:0007260)1.66862991
135Decreased central vision (HP:0007663)1.66752047
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.65507655
137Abnormality of alanine metabolism (HP:0010916)1.65507655
138Hyperalaninemia (HP:0003348)1.65507655
139Median cleft lip (HP:0000161)1.65302272
140Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65156348
141Cerebellar dysplasia (HP:0007033)1.64041126
142Ependymoma (HP:0002888)1.63985685
143Aplastic anemia (HP:0001915)1.63489388
144Recurrent otitis media (HP:0000403)1.62860232
145Abnormality of the duodenum (HP:0002246)1.62815868
146Dandy-Walker malformation (HP:0001305)1.62535489
147Atresia of the external auditory canal (HP:0000413)1.62034514
148Facial cleft (HP:0002006)1.60298086
149Highly arched eyebrow (HP:0002553)1.60045802
150Narrow forehead (HP:0000341)1.59291742
151Basal cell carcinoma (HP:0002671)1.58233562
152Entropion (HP:0000621)1.58188845
153Cutis marmorata (HP:0000965)1.57135781
154Aplasia/Hypoplasia of the patella (HP:0006498)1.56467354
155Abnormality of lateral ventricle (HP:0030047)1.56393849
156IgM deficiency (HP:0002850)1.56145561
157Duplicated collecting system (HP:0000081)1.55948236
158Astrocytoma (HP:0009592)1.55155213
159Abnormality of the astrocytes (HP:0100707)1.55155213
160Short ribs (HP:0000773)1.55115414
161Microtia (HP:0008551)1.54118011
162Aplasia/Hypoplasia of the sternum (HP:0006714)1.51563623
163Abnormal lung lobation (HP:0002101)1.51278723
164Optic nerve coloboma (HP:0000588)1.49617123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.39406517
2NEK23.71489302
3PDK43.13408441
4PDK33.13408441
5WEE13.12240721
6PNCK2.66125857
7CDK122.65356156
8MAP4K22.64467952
9MST42.53211006
10ACVR1B2.40732172
11PLK42.25323887
12TTK2.22109342
13PRKD32.21354969
14BMPR1B2.18323274
15RPS6KA42.09418850
16MAPK152.03206042
17MKNK11.89468493
18WNK31.88422000
19SRPK11.86299833
20ATR1.82711719
21NEK11.82074046
22EIF2AK11.79654170
23MKNK21.79267776
24PBK1.76797703
25STK391.76244039
26PLK11.71707476
27STK31.65682686
28AURKB1.59974318
29CHEK21.59502088
30BRSK21.58333466
31TAOK31.56583590
32PDK21.53481117
33CHEK11.48593874
34BUB11.45485079
35WNK41.45094596
36CDK41.43022342
37SCYL21.39711311
38TESK11.36111904
39MAP3K41.35931950
40BCR1.32129825
41PLK31.26977061
42TRIM281.26187976
43ATM1.25957006
44STK101.25641523
45MAP3K101.23057553
46NUAK11.22222618
47EEF2K1.22127962
48PASK1.21975123
49DYRK31.21864623
50BRD41.16871698
51MAP4K11.16008253
52TNIK1.15162331
53ADRBK21.12156206
54CDK71.09321484
55LATS11.08886149
56CASK1.08024757
57CCNB11.07777096
58OXSR11.06305839
59GRK11.06219532
60MAP3K81.05883554
61INSRR1.01143773
62JAK30.99219362
63MAPK130.97581315
64STK40.95401745
65PINK10.95220900
66CDK60.95009375
67CDK30.91520528
68CDK20.89085915
69AKT30.89025063
70TAF10.87918757
71STK160.87879150
72PIM10.86823344
73TLK10.85945444
74MELK0.85929635
75PTK2B0.82388919
76VRK10.79936909
77NME10.79233191
78CSNK1G10.78736221
79ZAK0.78090509
80CDK90.76838322
81AURKA0.76095578
82TGFBR10.75902700
83BCKDK0.74150497
84BRSK10.72334009
85TXK0.72098381
86BMPR20.71153947
87MAP3K140.68017584
88ALK0.67369705
89CDK10.67198364
90FES0.67074260
91RIPK40.66801614
92DMPK0.65800145
93PAK30.63114354
94TEC0.61480427
95EIF2AK20.60177636
96EIF2AK30.58332292
97STK38L0.57636073
98CSNK1G20.57570173
99CHUK0.57567514
100CDK80.56101114
101RAF10.55169826
102FRK0.54428969
103ZAP700.52303223
104CSNK1A1L0.51931960
105NLK0.51790040
106CSNK1G30.51430008
107PRKCE0.51150512
108PRKDC0.50608051
109CSNK2A20.49674615
110MARK30.48634064
111MAP2K70.48486437
112CLK10.48322341
113TSSK60.48129548
114TRPM70.47454963
115CSNK2A10.45459213
116ADRBK10.44927997
117KIT0.43604013
118VRK20.42708885
119BRAF0.42533711
120PLK20.42444608
121RPS6KA50.42003251
122ERBB30.41225033
123MAP3K60.40269566
124STK240.39482416
125PRKCQ0.39247145
126MAPK140.38846330
127CAMK1G0.37856585
128FGFR30.36024153
129RPS6KB20.35286922
130MAPKAPK50.35189553
131OBSCN0.34756069
132CSF1R0.34235639
133PRKCG0.34233519
134CSNK1E0.34024580
135NEK90.33285007
136SIK20.32813763
137FGFR10.32598183
138MTOR0.31150292
139MAP3K50.30540502
140AKT10.30246927
141CSNK1D0.29911854
142PIK3CA0.29820141
143CSNK1A10.28458697
144PIK3CG0.27843555
145GSK3B0.27066333
146EPHA40.26898709
147BTK0.26706991

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.89338836
2Protein export_Homo sapiens_hsa030602.95794143
3Mismatch repair_Homo sapiens_hsa034302.88551530
4Cell cycle_Homo sapiens_hsa041102.69431596
5RNA transport_Homo sapiens_hsa030132.60861273
6Homologous recombination_Homo sapiens_hsa034402.54342185
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52432866
8Base excision repair_Homo sapiens_hsa034102.45768358
9Fanconi anemia pathway_Homo sapiens_hsa034602.44757465
10Spliceosome_Homo sapiens_hsa030402.34138055
11Nucleotide excision repair_Homo sapiens_hsa034202.28104321
12Basal transcription factors_Homo sapiens_hsa030222.07259841
13Propanoate metabolism_Homo sapiens_hsa006402.00046846
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97338347
15mRNA surveillance pathway_Homo sapiens_hsa030151.96974486
16RNA degradation_Homo sapiens_hsa030181.84297741
17Selenocompound metabolism_Homo sapiens_hsa004501.81927912
18Phototransduction_Homo sapiens_hsa047441.77442046
19Non-homologous end-joining_Homo sapiens_hsa034501.66804427
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65594208
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65415863
22Oocyte meiosis_Homo sapiens_hsa041141.62591786
23Oxidative phosphorylation_Homo sapiens_hsa001901.56828188
24Huntingtons disease_Homo sapiens_hsa050161.54964607
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53226567
26p53 signaling pathway_Homo sapiens_hsa041151.47375424
27Butanoate metabolism_Homo sapiens_hsa006501.46340167
28Pyrimidine metabolism_Homo sapiens_hsa002401.44776363
29Herpes simplex infection_Homo sapiens_hsa051681.39150064
30Systemic lupus erythematosus_Homo sapiens_hsa053221.38241973
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.35418644
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34664903
33Parkinsons disease_Homo sapiens_hsa050121.34434153
34Antigen processing and presentation_Homo sapiens_hsa046121.34374006
35Nitrogen metabolism_Homo sapiens_hsa009101.31341746
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.31271125
37One carbon pool by folate_Homo sapiens_hsa006701.26012255
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24526708
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23926312
40Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22692755
41Linoleic acid metabolism_Homo sapiens_hsa005911.19862373
42Viral carcinogenesis_Homo sapiens_hsa052031.19201635
43RNA polymerase_Homo sapiens_hsa030201.19135903
44Steroid biosynthesis_Homo sapiens_hsa001001.18069093
45Epstein-Barr virus infection_Homo sapiens_hsa051691.10197814
46HTLV-I infection_Homo sapiens_hsa051661.09711861
47Measles_Homo sapiens_hsa051621.09533136
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.05986899
49MicroRNAs in cancer_Homo sapiens_hsa052061.05857655
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04548067
51Legionellosis_Homo sapiens_hsa051341.01970829
52Small cell lung cancer_Homo sapiens_hsa052221.01763664
53Caffeine metabolism_Homo sapiens_hsa002321.00288240
54Purine metabolism_Homo sapiens_hsa002301.00016444
55Ribosome_Homo sapiens_hsa030100.99638920
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.97947372
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.96093483
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.95359678
59Peroxisome_Homo sapiens_hsa041460.94057813
60Hepatitis B_Homo sapiens_hsa051610.92374116
61Leishmaniasis_Homo sapiens_hsa051400.92057512
62Tryptophan metabolism_Homo sapiens_hsa003800.91748786
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90792198
64Ether lipid metabolism_Homo sapiens_hsa005650.88649264
65Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87283343
66Influenza A_Homo sapiens_hsa051640.87005913
67Olfactory transduction_Homo sapiens_hsa047400.86718656
68B cell receptor signaling pathway_Homo sapiens_hsa046620.85513176
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84556084
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.82699636
71Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.82228845
72Shigellosis_Homo sapiens_hsa051310.81950115
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.81594402
74Asthma_Homo sapiens_hsa053100.81124978
75Allograft rejection_Homo sapiens_hsa053300.79414930
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79203777
77Chemical carcinogenesis_Homo sapiens_hsa052040.78541109
78Alcoholism_Homo sapiens_hsa050340.78028503
79Viral myocarditis_Homo sapiens_hsa054160.77202601
80Chronic myeloid leukemia_Homo sapiens_hsa052200.76384009
81Proteasome_Homo sapiens_hsa030500.76367117
82Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75314746
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74418231
84beta-Alanine metabolism_Homo sapiens_hsa004100.74402998
85Taste transduction_Homo sapiens_hsa047420.73008346
86Colorectal cancer_Homo sapiens_hsa052100.72993697
87Alzheimers disease_Homo sapiens_hsa050100.71868246
88Hedgehog signaling pathway_Homo sapiens_hsa043400.70908661
89Type I diabetes mellitus_Homo sapiens_hsa049400.70786918
90Osteoclast differentiation_Homo sapiens_hsa043800.70206934
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70204947
92Hematopoietic cell lineage_Homo sapiens_hsa046400.70192368
93Glutathione metabolism_Homo sapiens_hsa004800.69589827
94Pancreatic cancer_Homo sapiens_hsa052120.69398057
95Toxoplasmosis_Homo sapiens_hsa051450.69326753
96T cell receptor signaling pathway_Homo sapiens_hsa046600.68207448
97Dorso-ventral axis formation_Homo sapiens_hsa043200.67164980
98Regulation of autophagy_Homo sapiens_hsa041400.66559408
99Adherens junction_Homo sapiens_hsa045200.66408832
100Thyroid cancer_Homo sapiens_hsa052160.66159761
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66145134
102Graft-versus-host disease_Homo sapiens_hsa053320.65888827
103Metabolic pathways_Homo sapiens_hsa011000.65038271
104Retinol metabolism_Homo sapiens_hsa008300.64935241
105Nicotine addiction_Homo sapiens_hsa050330.64601208
106Apoptosis_Homo sapiens_hsa042100.64045814
107Primary immunodeficiency_Homo sapiens_hsa053400.62776470
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61875230
109Prostate cancer_Homo sapiens_hsa052150.61774413
110Long-term potentiation_Homo sapiens_hsa047200.60740201
111Lysine degradation_Homo sapiens_hsa003100.60677806
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58653025
113TGF-beta signaling pathway_Homo sapiens_hsa043500.58575869
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57630808
115Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57590926
116Pyruvate metabolism_Homo sapiens_hsa006200.57444284
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57411427
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57234283
119Circadian rhythm_Homo sapiens_hsa047100.56732938
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.56248186
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.55924465
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.55832794
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.54423991
124Cardiac muscle contraction_Homo sapiens_hsa042600.54166402
125TNF signaling pathway_Homo sapiens_hsa046680.54152471
126Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53612447
127Basal cell carcinoma_Homo sapiens_hsa052170.52719523
128Acute myeloid leukemia_Homo sapiens_hsa052210.51782783
129Salmonella infection_Homo sapiens_hsa051320.49373243
130AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48718477
131Glioma_Homo sapiens_hsa052140.47790245
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47747415
133Folate biosynthesis_Homo sapiens_hsa007900.47039825
134Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46502891
135Tuberculosis_Homo sapiens_hsa051520.46133969
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45884499
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45330802
138VEGF signaling pathway_Homo sapiens_hsa043700.45120143
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44764692
140Pathways in cancer_Homo sapiens_hsa052000.44654632
141Fatty acid degradation_Homo sapiens_hsa000710.44294090
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43907422
143Non-small cell lung cancer_Homo sapiens_hsa052230.43771544
144Vitamin digestion and absorption_Homo sapiens_hsa049770.43280398
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42295196
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.42164833
147ABC transporters_Homo sapiens_hsa020100.41771246
148mTOR signaling pathway_Homo sapiens_hsa041500.41691929
149Malaria_Homo sapiens_hsa051440.39827348
150HIF-1 signaling pathway_Homo sapiens_hsa040660.39513370
151Leukocyte transendothelial migration_Homo sapiens_hsa046700.39028749
152Estrogen signaling pathway_Homo sapiens_hsa049150.38815751
153Wnt signaling pathway_Homo sapiens_hsa043100.38334017
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38232085
155Amphetamine addiction_Homo sapiens_hsa050310.37177178
156Arachidonic acid metabolism_Homo sapiens_hsa005900.37069602
157FoxO signaling pathway_Homo sapiens_hsa040680.36764034
158Platelet activation_Homo sapiens_hsa046110.36020214
159Glucagon signaling pathway_Homo sapiens_hsa049220.35933833
160Fatty acid elongation_Homo sapiens_hsa000620.35804463
161Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35550207
162Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.35264296
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34675534
164Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33736860
165Fatty acid metabolism_Homo sapiens_hsa012120.30515499
166Hippo signaling pathway_Homo sapiens_hsa043900.29750049
167Fatty acid biosynthesis_Homo sapiens_hsa000610.26621423
168Serotonergic synapse_Homo sapiens_hsa047260.24209340
169Glycerolipid metabolism_Homo sapiens_hsa005610.23491603

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