CEP78

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a centrosomal protein that is both required for the regulation of centrosome-related events during the cell cycle, and required for ciliogenesis. The encoded protein has an N-terminal leucine-rich repeat (LRR) domain with six consecutive LRR repeats, and a C-terminal coiled-coil domain. It interacts with the N-terminal catalytic domain of polo-like kinase 4 (PLK4) and colocalizes with PLK4 to the distal end of the centriole. Naturally occurring mutations in this gene cause defects in primary cilia that result in retinal degeneration and sensorineural hearing loss which are associated with cone-rod degeneration disease as well as Usher syndrome. Low expression of this gene is associated with poor prognosis of colorectal cancer patients. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sphingosine metabolic process (GO:0006670)8.60020091
2diol metabolic process (GO:0034311)7.75113633
3sphingoid metabolic process (GO:0046519)7.25786468
4DNA methylation involved in gamete generation (GO:0043046)6.74052018
5paraxial mesoderm development (GO:0048339)6.73790638
6regulation of meiosis I (GO:0060631)6.50629138
7piRNA metabolic process (GO:0034587)5.96409448
8negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.80493790
9regulation of odontogenesis of dentin-containing tooth (GO:0042487)5.39787194
10protein K11-linked deubiquitination (GO:0035871)5.24720450
11serotonin receptor signaling pathway (GO:0007210)5.12717059
12DNA unwinding involved in DNA replication (GO:0006268)5.10541992
13centriole replication (GO:0007099)5.10371931
14negative regulation of cell cycle G2/M phase transition (GO:1902750)5.06953847
15positive regulation of developmental pigmentation (GO:0048087)4.88836505
16regulation of pigment cell differentiation (GO:0050932)4.85101751
17protein-chromophore linkage (GO:0018298)4.74477881
18protein localization to kinetochore (GO:0034501)4.73219143
19DNA strand elongation involved in DNA replication (GO:0006271)4.71447869
20DNA replication initiation (GO:0006270)4.61169373
21DNA strand elongation (GO:0022616)4.56187431
22telomere maintenance via semi-conservative replication (GO:0032201)4.43665359
23kinetochore organization (GO:0051383)4.26214864
24lipopolysaccharide biosynthetic process (GO:0009103)4.21986381
25negative regulation of DNA-dependent DNA replication (GO:2000104)4.19230313
26sulfate transmembrane transport (GO:1902358)4.17541918
27chromatin remodeling at centromere (GO:0031055)4.10833748
28mitotic metaphase plate congression (GO:0007080)4.09957037
29CENP-A containing nucleosome assembly (GO:0034080)4.08252620
30sulfate transport (GO:0008272)4.06092114
31protein localization to chromosome, centromeric region (GO:0071459)4.05882627
32DNA replication-dependent nucleosome assembly (GO:0006335)4.03881622
33DNA replication-dependent nucleosome organization (GO:0034723)4.03881622
34DNA replication checkpoint (GO:0000076)4.03814612
35notochord development (GO:0030903)4.02842957
36DNA replication-independent nucleosome assembly (GO:0006336)4.01574443
37DNA replication-independent nucleosome organization (GO:0034724)4.01574443
38telomere maintenance via recombination (GO:0000722)3.97825420
39mitotic nuclear envelope disassembly (GO:0007077)3.94164640
40regulation of protein glycosylation (GO:0060049)3.92406111
41nuclear pore organization (GO:0006999)3.92274863
42mitotic recombination (GO:0006312)3.89788704
43nucleobase biosynthetic process (GO:0046112)3.88423860
44somatic diversification of immune receptors via somatic mutation (GO:0002566)3.87594578
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.87594578
46nuclear pore complex assembly (GO:0051292)3.86199174
47kinetochore assembly (GO:0051382)3.85931854
48metaphase plate congression (GO:0051310)3.84213629
49meiotic cell cycle (GO:0051321)3.83274235
50attachment of spindle microtubules to kinetochore (GO:0008608)3.82236540
51dosage compensation (GO:0007549)3.71921826
52DNA damage induced protein phosphorylation (GO:0006975)3.69785282
53nuclear envelope disassembly (GO:0051081)3.69237427
54membrane disassembly (GO:0030397)3.69237427
55purine nucleobase biosynthetic process (GO:0009113)3.66397685
56reciprocal DNA recombination (GO:0035825)3.62937454
57reciprocal meiotic recombination (GO:0007131)3.62937454
58telomere maintenance via telomere lengthening (GO:0010833)3.61421189
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60957905
60nucleotide-excision repair, DNA gap filling (GO:0006297)3.60907473
61histone exchange (GO:0043486)3.60240700
62lipopolysaccharide metabolic process (GO:0008653)3.56538312
63mitotic sister chromatid segregation (GO:0000070)3.55973273
64mitotic chromosome condensation (GO:0007076)3.55225390
65protein localization to chromosome (GO:0034502)3.54920008
66spindle assembly involved in mitosis (GO:0090307)3.53226254
67positive regulation of meiosis (GO:0045836)3.52980181
68regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52182016
69IMP biosynthetic process (GO:0006188)3.49783452
70folic acid-containing compound biosynthetic process (GO:0009396)3.49087754
71regulation of double-strand break repair via homologous recombination (GO:0010569)3.47494402
72centriole assembly (GO:0098534)3.47467684
73ribonucleoprotein complex disassembly (GO:0032988)3.46396606
74establishment of integrated proviral latency (GO:0075713)3.45753858
75ATP-dependent chromatin remodeling (GO:0043044)3.45518952
76sister chromatid segregation (GO:0000819)3.43889149
77DNA geometric change (GO:0032392)3.42521627
78DNA duplex unwinding (GO:0032508)3.41749691
79regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.41108773
80regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.40293130
81DNA strand renaturation (GO:0000733)3.40286917
82gamma-aminobutyric acid signaling pathway (GO:0007214)3.38793607
83establishment of chromosome localization (GO:0051303)3.38694077
84mitotic sister chromatid cohesion (GO:0007064)3.36182762
85spindle assembly checkpoint (GO:0071173)3.32759258
86negative regulation of chromosome segregation (GO:0051985)3.31863743
87spindle checkpoint (GO:0031577)3.31301335
88DNA deamination (GO:0045006)3.30835379
89synapsis (GO:0007129)3.30243560
90formation of translation preinitiation complex (GO:0001731)3.29207655
91negative regulation of RNA splicing (GO:0033119)3.28939104
92DNA double-strand break processing (GO:0000729)3.28801316
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.28655637
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.28655637
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.28655637
96negative regulation of sister chromatid segregation (GO:0033046)3.28655637
97chromatin assembly or disassembly (GO:0006333)3.28288813
98regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.27865606
99negative regulation of histone methylation (GO:0031061)3.27666036
100pre-miRNA processing (GO:0031054)3.27531894
101regulation of histone H3-K9 methylation (GO:0051570)3.27324979
102translesion synthesis (GO:0019985)3.27000040
103negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.26335463
104positive regulation of meiotic cell cycle (GO:0051446)3.26014592
105mitotic spindle assembly checkpoint (GO:0007094)3.25835240
106positive regulation of chromosome segregation (GO:0051984)3.24275996
107somite rostral/caudal axis specification (GO:0032525)3.23724568
108regulation of chromatin binding (GO:0035561)3.23519315
109tachykinin receptor signaling pathway (GO:0007217)3.21516236
110DNA methylation (GO:0006306)3.21258946
111DNA alkylation (GO:0006305)3.21258946
112regulation of hair follicle development (GO:0051797)3.21109908
113postreplication repair (GO:0006301)3.19723325
114regulation of spindle organization (GO:0090224)3.19312526
115regulation of chromosome segregation (GO:0051983)3.18828972
116regulation of centriole replication (GO:0046599)3.18372942
117mitotic spindle checkpoint (GO:0071174)3.17559315
118regulation of nuclear cell cycle DNA replication (GO:0033262)3.16785482
119regulation of mitotic metaphase/anaphase transition (GO:0030071)3.15806071
120organelle disassembly (GO:1903008)3.15243242
121regulation of rhodopsin mediated signaling pathway (GO:0022400)3.14990295
122regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.14305245
123negative regulation of mRNA processing (GO:0050686)3.11967456
124regulation of centrosome cycle (GO:0046605)3.10578875
125gene silencing by RNA (GO:0031047)3.10450888
126mismatch repair (GO:0006298)3.07769847
127IMP metabolic process (GO:0046040)3.06154043
128regulation of sister chromatid segregation (GO:0033045)3.06138073
129regulation of mitotic sister chromatid separation (GO:0010965)3.06138073
130regulation of mitotic sister chromatid segregation (GO:0033047)3.06138073
131meiotic chromosome segregation (GO:0045132)3.06085070
132histone H2A acetylation (GO:0043968)3.04957280
133spliceosomal snRNP assembly (GO:0000387)3.04417964
134regulation of telomere maintenance via telomerase (GO:0032210)3.04141723
135telomere organization (GO:0032200)3.03124871
136regulation of centrosome duplication (GO:0010824)3.03007862
137maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.02720488
138telomere maintenance (GO:0000723)3.02171457
139chromosome segregation (GO:0007059)3.00867031
140rhodopsin mediated signaling pathway (GO:0016056)2.99554684
141pore complex assembly (GO:0046931)2.96746426
142RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.95387400
143mRNA splicing, via spliceosome (GO:0000398)2.95387400
144RNA splicing, via transesterification reactions (GO:0000375)2.94105391
145base-excision repair (GO:0006284)2.93681013
146regulation of sister chromatid cohesion (GO:0007063)2.93183974
147replication fork processing (GO:0031297)2.89404699
148microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.89203364
149nodal signaling pathway (GO:0038092)2.88743178
150aspartate family amino acid catabolic process (GO:0009068)2.87317261
151centrosome organization (GO:0051297)2.87060853
152female gamete generation (GO:0007292)2.86454007
153flavonoid metabolic process (GO:0009812)2.85784474
154regulation of gene silencing by RNA (GO:0060966)2.84766719
155regulation of posttranscriptional gene silencing (GO:0060147)2.84766719
156regulation of gene silencing by miRNA (GO:0060964)2.84766719
157heme transport (GO:0015886)2.84474192
158microtubule organizing center organization (GO:0031023)2.79719684
159SMAD protein complex assembly (GO:0007183)2.72140924
160regulation of G2/M transition of mitotic cell cycle (GO:0010389)2.72115071
161neural tube formation (GO:0001841)2.70079226
162recombinational repair (GO:0000725)2.69564262
163regulation of DNA endoreduplication (GO:0032875)2.69069366
164spindle assembly (GO:0051225)2.68810138
165behavioral response to nicotine (GO:0035095)2.67927151
166regulation of appetite (GO:0032098)2.67074590
167double-strand break repair via homologous recombination (GO:0000724)2.66444470
168centrosome duplication (GO:0051298)2.65336436
169DNA methylation or demethylation (GO:0044728)2.63309642
170protein K48-linked deubiquitination (GO:0071108)2.63220652
171oogenesis (GO:0048477)2.62553053
172sympathetic nervous system development (GO:0048485)2.61581890
173detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60158140
174resolution of meiotic recombination intermediates (GO:0000712)2.59836984
175protein K6-linked ubiquitination (GO:0085020)2.59818465
176negative regulation of glycoprotein biosynthetic process (GO:0010561)2.59096777
177regulation of hippo signaling (GO:0035330)2.58975135
178sulfation (GO:0051923)2.57536524
179biotin metabolic process (GO:0006768)2.56290399
180cellular response to gamma radiation (GO:0071480)2.54771502
181tyrosine metabolic process (GO:0006570)2.53980917
182microtubule depolymerization (GO:0007019)2.53976120
183regulation of cell cycle G2/M phase transition (GO:1902749)2.53366472
184hematopoietic stem cell proliferation (GO:0071425)2.51213286
185negative regulation of cell division (GO:0051782)2.50761279

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.68493040
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.82089541
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.23136769
4IGF1R_20145208_ChIP-Seq_DFB_Human4.17314120
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.15673707
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.47142268
7GBX2_23144817_ChIP-Seq_PC3_Human3.34721172
8EZH2_22144423_ChIP-Seq_EOC_Human3.23532428
9AR_21572438_ChIP-Seq_LNCaP_Human3.22317498
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.12142416
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.89928839
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81269261
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75310885
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.69120248
15* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62125842
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.56580257
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.52605903
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.50966038
19ZNF274_21170338_ChIP-Seq_K562_Hela2.48688958
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43450936
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.43058826
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42705060
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.42588590
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.39258659
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.38299015
26ETS1_20019798_ChIP-Seq_JURKAT_Human2.35855304
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.35234285
28TAF15_26573619_Chip-Seq_HEK293_Human2.29306716
29FLI1_27457419_Chip-Seq_LIVER_Mouse2.24998459
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.23046788
31XRN2_22483619_ChIP-Seq_HELA_Human2.22765334
32* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17234538
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13649196
34FUS_26573619_Chip-Seq_HEK293_Human2.12713515
35VDR_23849224_ChIP-Seq_CD4+_Human2.09558567
36* P300_19829295_ChIP-Seq_ESCs_Human2.07551489
37POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05324135
38AR_21909140_ChIP-Seq_LNCAP_Human2.03732551
39MYCN_18555785_ChIP-Seq_MESCs_Mouse2.03306529
40ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03295268
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.99652103
42CIITA_25753668_ChIP-Seq_RAJI_Human1.96340710
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94252590
44TP63_19390658_ChIP-ChIP_HaCaT_Human1.93122862
45EWS_26573619_Chip-Seq_HEK293_Human1.93075879
46ELF1_17652178_ChIP-ChIP_JURKAT_Human1.91885232
47* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.91664490
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88948796
49GABP_19822575_ChIP-Seq_HepG2_Human1.88690134
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.88354515
51E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87372994
52FOXP3_21729870_ChIP-Seq_TREG_Human1.87244513
53ER_23166858_ChIP-Seq_MCF-7_Human1.86013843
54THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85511964
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.84810438
56VDR_22108803_ChIP-Seq_LS180_Human1.82164419
57* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.81547649
58TTF2_22483619_ChIP-Seq_HELA_Human1.79039317
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.78089816
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74258806
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74125442
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69363787
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67394201
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67007177
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64427223
66STAT3_23295773_ChIP-Seq_U87_Human1.62947686
67NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62785679
68MYC_22102868_ChIP-Seq_BL_Human1.60944268
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58207219
70KDM5A_27292631_Chip-Seq_BREAST_Human1.57305116
71DCP1A_22483619_ChIP-Seq_HELA_Human1.57103380
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.55733224
73* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55567794
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53322697
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52285179
76AR_25329375_ChIP-Seq_VCAP_Human1.52123096
77ELK1_19687146_ChIP-ChIP_HELA_Human1.49569780
78* TCF4_23295773_ChIP-Seq_U87_Human1.48078924
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.47653079
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46409425
81POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.46409425
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.45247269
83SMAD4_21799915_ChIP-Seq_A2780_Human1.44658114
84* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44537952
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44513612
86HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42899348
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.42176308
88* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41734847
89PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40291994
90PIAS1_25552417_ChIP-Seq_VCAP_Human1.39249017
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.39017002
92TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38461641
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37403853
94CBP_20019798_ChIP-Seq_JUKART_Human1.37403853
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37335449
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35292228
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.35264064
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32392297
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.32196058
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.31934157
101* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31862263
102FLI1_21867929_ChIP-Seq_TH2_Mouse1.30902618
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30325468
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30274937
105ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30199831
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29474718
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29255031
108RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28119625
109TP53_16413492_ChIP-PET_HCT116_Human1.27661318
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27099614
111SALL1_21062744_ChIP-ChIP_HESCs_Human1.25740686
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25388108
113BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24986465
114FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24274769
115SMAD3_21741376_ChIP-Seq_EPCs_Human1.23805875
116NANOG_19829295_ChIP-Seq_ESCs_Human1.23088360
117SOX2_19829295_ChIP-Seq_ESCs_Human1.23088360
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21308342
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20698511
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19991741
121KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.19230353
122LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18107339
123HOXB7_26014856_ChIP-Seq_BT474_Human1.18053400
124OCT4_21477851_ChIP-Seq_ESCs_Mouse1.17380272
125TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17137438
126* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16925827
127NANOG_21062744_ChIP-ChIP_HESCs_Human1.15356323
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15354327
129TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15253694
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15035121
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14458550
132TBX3_20139965_ChIP-Seq_ESCs_Mouse1.14393155
133* SMAD4_21741376_ChIP-Seq_EPCs_Human1.13641205
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.13491318
135TBX3_20139965_ChIP-Seq_MESCs_Mouse1.13160682
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12530017
137ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12075670
138TCF4_22108803_ChIP-Seq_LS180_Human1.10644843
139* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.10309159
140CRX_20693478_ChIP-Seq_RETINA_Mouse1.10179707
141MYC_18940864_ChIP-ChIP_HL60_Human1.09909498
142RNF2_27304074_Chip-Seq_NSC_Mouse1.09443299
143TP53_22573176_ChIP-Seq_HFKS_Human1.08098688
144SOX9_26525672_Chip-Seq_HEART_Mouse1.07813127
145SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07512102
146KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06533490
147RUNX2_22187159_ChIP-Seq_PCA_Human1.06000746
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05005618
149TFEB_21752829_ChIP-Seq_HELA_Human1.04224587
150SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.03589468
151AR_19668381_ChIP-Seq_PC3_Human1.02955274
152PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02323214
153SMAD3_21741376_ChIP-Seq_ESCs_Human1.02198096
154* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01623261
155* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01221374
156PRDM14_20953172_ChIP-Seq_ESCs_Human1.00558738
157KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00482481
158REST_21632747_ChIP-Seq_MESCs_Mouse0.99405850
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.98490631
160SRF_21415370_ChIP-Seq_HL-1_Mouse0.98144092
161BCAT_22108803_ChIP-Seq_LS180_Human0.97566137
162FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97405693
163GATA3_21878914_ChIP-Seq_MCF-7_Human0.97308478
164SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96618640
165CBX2_27304074_Chip-Seq_ESCs_Mouse0.96262734
166PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.96143105
167FOXA1_25329375_ChIP-Seq_VCAP_Human0.95908087
168FOXA1_27270436_Chip-Seq_PROSTATE_Human0.95908087
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.94189775
170ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94089445
171GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91613753
172EZH2_27304074_Chip-Seq_ESCs_Mouse0.90656382
173HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88761770
174SOX2_16153702_ChIP-ChIP_HESCs_Human0.88586475
175VDR_21846776_ChIP-Seq_THP-1_Human0.84700960
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83626829
177FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.83515867
178NANOG_16153702_ChIP-ChIP_HESCs_Human0.83415165
179ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78082656
180NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.77754122
181TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77288718
182SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.77149588
183ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76641612
184KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.76371490
185NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75983708

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.92967929
2MP0002837_dystrophic_cardiac_calcinosis6.40465280
3MP0005171_absent_coat_pigmentation5.46685267
4MP0003693_abnormal_embryo_hatching5.03296002
5MP0010094_abnormal_chromosome_stability4.51054275
6MP0003111_abnormal_nucleus_morphology4.00525585
7MP0000569_abnormal_digit_pigmentation3.83445299
8MP0004957_abnormal_blastocyst_morpholog3.70648288
9MP0008057_abnormal_DNA_replication3.66264834
10MP0003077_abnormal_cell_cycle3.59603081
11MP0008058_abnormal_DNA_repair3.50746833
12MP0003646_muscle_fatigue3.20747837
13MP0008877_abnormal_DNA_methylation3.20516086
14MP0003123_paternal_imprinting3.03651890
15MP0008007_abnormal_cellular_replicative2.73147634
16MP0003121_genomic_imprinting2.70762310
17MP0003045_fibrosis2.57994411
18MP0008932_abnormal_embryonic_tissue2.40412961
19MP0003787_abnormal_imprinting2.30734278
20MP0008789_abnormal_olfactory_epithelium2.23930101
21MP0001730_embryonic_growth_arrest2.20832016
22MP0000350_abnormal_cell_proliferation2.16108064
23MP0006292_abnormal_olfactory_placode2.06653823
24MP0004381_abnormal_hair_follicle2.05208326
25MP0002138_abnormal_hepatobiliary_system2.03400810
26MP0005394_taste/olfaction_phenotype1.98296290
27MP0005499_abnormal_olfactory_system1.98296290
28MP0003890_abnormal_embryonic-extraembry1.98117349
29MP0010030_abnormal_orbit_morphology1.95653185
30MP0001984_abnormal_olfaction1.78454089
31MP0003786_premature_aging1.76755062
32MP0002085_abnormal_embryonic_tissue1.73556942
33MP0010352_gastrointestinal_tract_polyps1.66450219
34MP0002084_abnormal_developmental_patter1.64446733
35MP0001293_anophthalmia1.64408003
36MP0002938_white_spotting1.64175702
37MP0005380_embryogenesis_phenotype1.61051472
38MP0001672_abnormal_embryogenesis/_devel1.61051472
39MP0002160_abnormal_reproductive_system1.60896420
40MP0001697_abnormal_embryo_size1.60732601
41MP0005075_abnormal_melanosome_morpholog1.58446259
42MP0005670_abnormal_white_adipose1.57884315
43MP0003879_abnormal_hair_cell1.57745592
44MP0010307_abnormal_tumor_latency1.57030314
45MP0002210_abnormal_sex_determination1.53998270
46MP0002080_prenatal_lethality1.49931306
47MP0002653_abnormal_ependyma_morphology1.48877864
48MP0002396_abnormal_hematopoietic_system1.48065167
49MP0004197_abnormal_fetal_growth/weight/1.42576827
50MP0003119_abnormal_digestive_system1.40839140
51MP0004147_increased_porphyrin_level1.36584133
52MP0003984_embryonic_growth_retardation1.35063939
53MP0002088_abnormal_embryonic_growth/wei1.33328279
54MP0001145_abnormal_male_reproductive1.32778984
55MP0000490_abnormal_crypts_of1.31779860
56MP0000427_abnormal_hair_cycle1.31730374
57MP0002095_abnormal_skin_pigmentation1.30405238
58MP0000313_abnormal_cell_death1.29087089
59MP0000537_abnormal_urethra_morphology1.28921694
60MP0004133_heterotaxia1.28589936
61MP0003183_abnormal_peptide_metabolism1.27386418
62MP0002086_abnormal_extraembryonic_tissu1.26871663
63MP0002735_abnormal_chemical_nociception1.23963046
64MP0001929_abnormal_gametogenesis1.22766065
65MP0005174_abnormal_tail_pigmentation1.21614890
66MP0003567_abnormal_fetal_cardiomyocyte1.20573052
67MP0003937_abnormal_limbs/digits/tail_de1.20171646
68MP0003718_maternal_effect1.19222327
69MP0003941_abnormal_skin_development1.18612454
70MP0000653_abnormal_sex_gland1.18544524
71MP0004043_abnormal_pH_regulation1.17762760
72MP0003315_abnormal_perineum_morphology1.14858434
73MP0005085_abnormal_gallbladder_physiolo1.14386128
74MP0005551_abnormal_eye_electrophysiolog1.14128444
75MP0002075_abnormal_coat/hair_pigmentati1.13379537
76MP0009053_abnormal_anal_canal1.13053569
77MP0002019_abnormal_tumor_incidence1.12844766
78MP0003195_calcinosis1.12482027
79MP0002928_abnormal_bile_duct1.11379528
80MP0003861_abnormal_nervous_system1.10358485
81MP0005389_reproductive_system_phenotype1.09705357
82MP0002168_other_aberrant_phenotype1.08928034
83MP0009672_abnormal_birth_weight1.07612741
84MP0000778_abnormal_nervous_system1.06637401
85MP0002751_abnormal_autonomic_nervous1.06312467
86MP0005395_other_phenotype1.05504423
87MP0003283_abnormal_digestive_organ1.03671936
88MP0006276_abnormal_autonomic_nervous1.03607211
89MP0005076_abnormal_cell_differentiation1.02716152
90MP0009703_decreased_birth_body1.02650550
91MP0002102_abnormal_ear_morphology1.01091209
92MP0002111_abnormal_tail_morphology0.99823485
93MP0004142_abnormal_muscle_tone0.99679372
94MP0003122_maternal_imprinting0.96811841
95MP0001324_abnormal_eye_pigmentation0.95874838
96MP0001119_abnormal_female_reproductive0.95327281
97MP0009046_muscle_twitch0.94378958
98MP0000749_muscle_degeneration0.93710926
99MP0001286_abnormal_eye_development0.92114909
100MP0001486_abnormal_startle_reflex0.90584077
101MP0006054_spinal_hemorrhage0.90163541
102MP0002272_abnormal_nervous_system0.88022881
103MP0003763_abnormal_thymus_physiology0.87598822
104MP0003878_abnormal_ear_physiology0.87035646
105MP0005377_hearing/vestibular/ear_phenot0.87035646
106MP0009745_abnormal_behavioral_response0.85807968
107MP0003137_abnormal_impulse_conducting0.85192950
108MP0006072_abnormal_retinal_apoptosis0.84096951
109MP0002092_abnormal_eye_morphology0.83901731
110MP0003698_abnormal_male_reproductive0.83228518
111MP0004808_abnormal_hematopoietic_stem0.83060851
112MP0005253_abnormal_eye_physiology0.81686040
113MP0002114_abnormal_axial_skeleton0.81528829
114MP0000703_abnormal_thymus_morphology0.80860716
115MP0003935_abnormal_craniofacial_develop0.80401155
116MP0001186_pigmentation_phenotype0.78935404
117MP0002697_abnormal_eye_size0.78123351
118MP0002116_abnormal_craniofacial_bone0.77538214
119MP0002234_abnormal_pharynx_morphology0.76720283
120MP0005187_abnormal_penis_morphology0.75258985
121MP0000566_synostosis0.74979205
122MP0002233_abnormal_nose_morphology0.74858369
123MP0005384_cellular_phenotype0.74345657
124MP0003755_abnormal_palate_morphology0.73715224
125MP0002932_abnormal_joint_morphology0.73599580
126MP0000432_abnormal_head_morphology0.72413231
127MP0000049_abnormal_middle_ear0.72108830
128MP0002736_abnormal_nociception_after0.70942921
129MP0002161_abnormal_fertility/fecundity0.70160953
130MP0000428_abnormal_craniofacial_morphol0.69559546
131MP0000383_abnormal_hair_follicle0.68271717
132MP0003252_abnormal_bile_duct0.66302899
133MP0003115_abnormal_respiratory_system0.66212875
134MP0001529_abnormal_vocalization0.66112945
135MP0008770_decreased_survivor_rate0.65963262
136MP0009697_abnormal_copulation0.65667455
137MP0000631_abnormal_neuroendocrine_gland0.65274902
138MP0002081_perinatal_lethality0.65053422
139MP0001968_abnormal_touch/_nociception0.63771616
140MP0002269_muscular_atrophy0.63765471
141MP0002064_seizures0.62632797
142MP0002572_abnormal_emotion/affect_behav0.62189792
143MP0002277_abnormal_respiratory_mucosa0.61797347
144MP0009333_abnormal_splenocyte_physiolog0.61731824
145MP0005195_abnormal_posterior_eye0.61191821
146MP0000358_abnormal_cell_content/0.61118991
147MP0001919_abnormal_reproductive_system0.60692519
148MP0002009_preneoplasia0.60285779
149MP0005621_abnormal_cell_physiology0.59845315
150MP0000372_irregular_coat_pigmentation0.59642276
151MP0003221_abnormal_cardiomyocyte_apopto0.59482989
152MP0003942_abnormal_urinary_system0.59474352
153MP0002752_abnormal_somatic_nervous0.58963983
154MP0003699_abnormal_female_reproductive0.58745506
155MP0002177_abnormal_outer_ear0.57132326
156MP0001501_abnormal_sleep_pattern0.57080971
157MP0000534_abnormal_ureter_morphology0.55530194
158MP0001970_abnormal_pain_threshold0.54207564
159MP0000026_abnormal_inner_ear0.53630955

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.84966592
2Amelogenesis imperfecta (HP:0000705)5.47658641
3Pancreatic cysts (HP:0001737)4.33189285
4Birth length less than 3rd percentile (HP:0003561)4.23771024
5Acanthocytosis (HP:0001927)4.07209578
6Patellar aplasia (HP:0006443)4.01857958
7Medulloblastoma (HP:0002885)3.92392756
8Colon cancer (HP:0003003)3.78208105
9Aplasia/Hypoplasia of the patella (HP:0006498)3.72508374
10Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.63399972
11Ependymoma (HP:0002888)3.57566505
12Parakeratosis (HP:0001036)3.53389966
13Chromsome breakage (HP:0040012)3.39515728
14Dialeptic seizures (HP:0011146)3.25804586
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.23172862
16Impulsivity (HP:0100710)3.19521153
17Breast hypoplasia (HP:0003187)3.06448721
18Degeneration of anterior horn cells (HP:0002398)3.02367855
19Abnormality of the anterior horn cell (HP:0006802)3.02367855
20Pancreatic fibrosis (HP:0100732)2.98760517
21Selective tooth agenesis (HP:0001592)2.96520337
22Nephronophthisis (HP:0000090)2.93536255
23Abnormality of chromosome stability (HP:0003220)2.91527582
24Abnormality of the labia minora (HP:0012880)2.90660362
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.81885474
26Bilateral sensorineural hearing impairment (HP:0008619)2.81264643
27Abnormality of the renal medulla (HP:0100957)2.80909189
28Meckel diverticulum (HP:0002245)2.79520950
29Small intestinal stenosis (HP:0012848)2.76504274
30Duodenal stenosis (HP:0100867)2.76504274
31Abnormality of the ileum (HP:0001549)2.75620574
32Increased nuchal translucency (HP:0010880)2.75380843
33Abnormality of the renal cortex (HP:0011035)2.75040623
34Proximal amyotrophy (HP:0007126)2.74524337
35Absent radius (HP:0003974)2.71557556
36True hermaphroditism (HP:0010459)2.71489598
37Focal seizures (HP:0007359)2.67264849
38Rhabdomyosarcoma (HP:0002859)2.66527604
39Abnormal number of incisors (HP:0011064)2.62469214
40Reticulocytopenia (HP:0001896)2.62109415
41Cerebellar dysplasia (HP:0007033)2.62003978
42Chronic hepatic failure (HP:0100626)2.60987949
43Myelodysplasia (HP:0002863)2.60665640
44Aplastic anemia (HP:0001915)2.60043909
45Astrocytoma (HP:0009592)2.58769067
46Abnormality of the astrocytes (HP:0100707)2.58769067
47Absent forearm bone (HP:0003953)2.56517545
48Aplasia involving forearm bones (HP:0009822)2.56517545
49Abnormal lung lobation (HP:0002101)2.56076472
50Pendular nystagmus (HP:0012043)2.55646840
51Agnosia (HP:0010524)2.52669057
52Abnormality of the preputium (HP:0100587)2.51040944
53Nephroblastoma (Wilms tumor) (HP:0002667)2.48443638
54Supernumerary spleens (HP:0009799)2.43595211
55Ectopic kidney (HP:0000086)2.41689560
56Aplasia/Hypoplasia of the sternum (HP:0006714)2.41525952
57Glioma (HP:0009733)2.41439812
58Abnormality of the duodenum (HP:0002246)2.40505718
59Vertebral arch anomaly (HP:0008438)2.39740108
60Pelvic girdle muscle weakness (HP:0003749)2.36994068
61Abnormality of the carotid arteries (HP:0005344)2.35834358
62Aplasia/Hypoplasia of the tibia (HP:0005772)2.35770374
63Clubbing of toes (HP:0100760)2.35381052
64Molar tooth sign on MRI (HP:0002419)2.34855751
65Abnormality of midbrain morphology (HP:0002418)2.34855751
66Neoplasm of the oral cavity (HP:0100649)2.34831997
67Rectal prolapse (HP:0002035)2.34037455
68Cystic liver disease (HP:0006706)2.33621290
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.32226234
70Congenital stationary night blindness (HP:0007642)2.31286364
71Sloping forehead (HP:0000340)2.30423776
7211 pairs of ribs (HP:0000878)2.28144647
73Horseshoe kidney (HP:0000085)2.27382571
74Embryonal renal neoplasm (HP:0011794)2.26251707
75Absent thumb (HP:0009777)2.25910898
76Facial hemangioma (HP:0000329)2.25382721
77Overlapping toe (HP:0001845)2.24451213
78Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.24325010
79Short 4th metacarpal (HP:0010044)2.24325010
80Neoplasm of striated muscle (HP:0009728)2.24320218
81Renal duplication (HP:0000075)2.23985479
82Oral leukoplakia (HP:0002745)2.19893703
83Atresia of the external auditory canal (HP:0000413)2.19422882
84Abnormality of DNA repair (HP:0003254)2.19063533
85Volvulus (HP:0002580)2.15833817
86Enlarged kidneys (HP:0000105)2.15414515
87Premature graying of hair (HP:0002216)2.15199881
88Synostosis of carpal bones (HP:0005048)2.13482430
89Hypoplastic iliac wings (HP:0002866)2.13427382
90Type II lissencephaly (HP:0007260)2.13105754
91Rough bone trabeculation (HP:0100670)2.12551854
92Cafe-au-lait spot (HP:0000957)2.10550976
93Carpal bone hypoplasia (HP:0001498)2.09196126
94Progressive inability to walk (HP:0002505)2.08726691
95Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.08711327
96Tracheoesophageal fistula (HP:0002575)2.06891840
97Cerebral hypomyelination (HP:0006808)2.03897733
98Neoplasm of the pancreas (HP:0002894)2.02163606
99Basal cell carcinoma (HP:0002671)2.01992481
100Neoplasm of the adrenal cortex (HP:0100641)2.01626780
101Tubular atrophy (HP:0000092)2.00965909
102Abnormality of cells of the erythroid lineage (HP:0012130)2.00596997
103Facial cleft (HP:0002006)2.00514057
104Cellular immunodeficiency (HP:0005374)1.98014275
105Decreased circulating renin level (HP:0003351)1.97344704
106Slender long bone (HP:0003100)1.96138414
107Proximal placement of thumb (HP:0009623)1.94884750
108Abnormal number of erythroid precursors (HP:0012131)1.94852897
109Abnormality of the hip-girdle musculature (HP:0001445)1.94617643
110Abnormality of the musculature of the pelvis (HP:0001469)1.94617643
111Bone marrow hypocellularity (HP:0005528)1.94118488
112Hypoplasia of the pons (HP:0012110)1.93880440
113Anencephaly (HP:0002323)1.93499713
114Neoplasm of the colon (HP:0100273)1.93372234
115Erythroderma (HP:0001019)1.90603367
116Hematochezia (HP:0002573)1.88694547
117Triphalangeal thumb (HP:0001199)1.87531168
118Congenital ichthyosiform erythroderma (HP:0007431)1.87285035
119Missing ribs (HP:0000921)1.85484916
120Small hand (HP:0200055)1.85137894
121Deviation of the thumb (HP:0009603)1.85117650
122High pitched voice (HP:0001620)1.84662888
123Atrophy/Degeneration involving motor neurons (HP:0007373)1.84323663
124Duplicated collecting system (HP:0000081)1.83993172
125Abnormality of the pons (HP:0007361)1.83674132
126Oligodactyly (hands) (HP:0001180)1.82497698
127Poikilocytosis (HP:0004447)1.81744135
128Fibular aplasia (HP:0002990)1.81715239
129Aplasia/hypoplasia of the humerus (HP:0006507)1.81661565
130Hyperglycinuria (HP:0003108)1.81175467
131Preaxial foot polydactyly (HP:0001841)1.81156304
132Abdominal situs inversus (HP:0003363)1.80193021
133Abnormality of abdominal situs (HP:0011620)1.80193021
134Type I transferrin isoform profile (HP:0003642)1.79601094
135Breast aplasia (HP:0100783)1.79558664
136Short thumb (HP:0009778)1.78889807
137Retinitis pigmentosa (HP:0000510)1.77756418
138Arteriovenous malformation (HP:0100026)1.77656873
139Abnormality of the metopic suture (HP:0005556)1.77450036
140Inability to walk (HP:0002540)1.76975173
141Oligohydramnios (HP:0001562)1.76127413
142Diastasis recti (HP:0001540)1.75949634
143Hyperventilation (HP:0002883)1.75506925
144Bony spicule pigmentary retinopathy (HP:0007737)1.75291788
145Oligodactyly (HP:0012165)1.75031089
146Abnormality of the renal collecting system (HP:0004742)1.73661602
147Ovarian neoplasm (HP:0100615)1.73224147
148Spina bifida occulta (HP:0003298)1.73189977
149Prominent metopic ridge (HP:0005487)1.73089063
150Renovascular hypertension (HP:0100817)1.71774015
151Prominent nose (HP:0000448)1.71450400
152Attenuation of retinal blood vessels (HP:0007843)1.71329128
153Congenital hepatic fibrosis (HP:0002612)1.70904727
154Intestinal atresia (HP:0011100)1.70800651
155Preaxial hand polydactyly (HP:0001177)1.69661452
156Conjunctival telangiectasia (HP:0000524)1.69172308
157Absent epiphyses (HP:0010577)1.68553186
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.68553186
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.68239388
160Abnormal pancreas size (HP:0012094)1.67011992
161Lissencephaly (HP:0001339)1.65622718
162Dynein arm defect of respiratory motile cilia (HP:0012255)1.65444613
163Absent/shortened dynein arms (HP:0200106)1.65444613
164Dandy-Walker malformation (HP:0001305)1.62721880
165Congenital sensorineural hearing impairment (HP:0008527)1.59719361
166Optic nerve hypoplasia (HP:0000609)1.59423621

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.05609528
2BUB14.57742067
3FRK4.28686143
4WEE13.50046691
5SRPK13.50025535
6NEK22.81198046
7PLK42.59577028
8TTK2.50590717
9ERBB32.39694136
10EIF2AK12.33883541
11BMPR1B2.22177212
12PASK2.19096239
13TSSK62.16246233
14PLK12.15282952
15PRKD32.10969067
16WNK32.06996181
17NLK2.04546749
18MKNK12.03763575
19DYRK31.99164173
20CDK121.98407497
21ATR1.94329884
22STK381.90715754
23PLK31.80849747
24CCNB11.75405452
25NEK11.74903497
26BRD41.67191755
27VRK11.67011122
28CDK71.65414278
29CHEK21.62036515
30AURKB1.61500104
31MKNK21.56205147
32EEF2K1.48258660
33MAP3K101.44868538
34AURKA1.43598029
35BRSK21.43557309
36RPS6KB21.41570886
37STK161.39884195
38CHEK11.39219470
39MAP2K21.36360328
40TAF11.30701490
41EIF2AK31.30186621
42ACVR1B1.28837290
43PINK11.27427764
44BRSK11.23341888
45SCYL21.21729681
46BRAF1.21235140
47RPS6KA41.21044051
48CDK41.17686749
49TLK11.14666652
50TESK21.14568426
51MAP3K81.12987799
52EPHA21.04483218
53ATM1.02074342
54CSNK1G31.01736251
55CDK20.99733526
56PRPF4B0.97194387
57LIMK10.92973102
58STK40.92202484
59CDK80.87955681
60BMPR20.87433299
61MAP3K60.84880728
62KSR10.82724160
63PKN20.81933870
64CDK10.81335693
65DYRK20.80927958
66TAOK20.80113606
67NUAK10.79691550
68TNIK0.77674601
69CSNK1A1L0.76912714
70FLT30.74954054
71MELK0.74797384
72TXK0.71722205
73CSNK1G10.71341581
74STK100.70571136
75TESK10.69550147
76ADRBK20.69238188
77CSNK1G20.66078035
78WNK40.63851849
79ZAK0.62969737
80MAP3K40.62008959
81CSNK2A20.58795142
82EIF2AK20.58727652
83STK390.58522108
84YES10.57959288
85PRKAA20.56964577
86PAK40.56568546
87MAPK130.55814978
88TGFBR10.54570948
89CASK0.54205197
90CDK60.54171036
91ADRBK10.52105718
92LATS20.51769392
93CSNK2A10.50687929
94STK30.50570809
95UHMK10.49044855
96PAK10.48756363
97OXSR10.47426632
98PIM10.46686428
99GRK70.46661974
100DYRK1B0.46495539
101PRKDC0.44644022
102STK38L0.43979163
103PRKCI0.43657208
104CDK30.42901526
105MAP3K20.42750153
106MAP4K20.41479876
107CSNK1E0.40652297
108GRK10.40379828
109PNCK0.39743012
110PLK20.38945267
111RPS6KA50.38772129
112STK110.37641590
113SIK30.37043939
114AKT10.36365640
115TAOK30.34771428
116PIK3CG0.34748975
117NME10.34133068
118CDK90.34112818
119AKT20.34024999
120CSNK1D0.33884661
121CDK180.33861202
122MAPK140.33803765
123CDK190.33662582
124KSR20.31614715
125CDK11A0.31348362
126LATS10.31099032
127INSRR0.31084745
128EPHA40.30498574
129MTOR0.30310137
130DAPK10.30219541
131PBK0.29816314
132AKT30.29465724
133RAF10.29274329
134FGFR10.29131034
135CDK150.28906394
136GSK3B0.28713628
137NEK90.27850217
138TRIM280.24718665
139BCR0.24592974
140CAMK1D0.23819315
141CAMK1G0.23064019
142NTRK30.21730980
143NTRK20.20697172
144MARK10.20612127
145PRKCG0.20187426
146PDPK10.19175232
147MAP2K10.18095849
148MAPKAPK50.16744185
149FGFR20.16253796
150PRKCZ0.14144763
151MOS0.13804676
152PRKD10.12895154

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.17204263
2Mismatch repair_Homo sapiens_hsa034304.62109275
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.46210657
4Phototransduction_Homo sapiens_hsa047444.04092420
5Spliceosome_Homo sapiens_hsa030403.52815443
6Base excision repair_Homo sapiens_hsa034103.44528181
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.40326211
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.23556251
9RNA transport_Homo sapiens_hsa030133.19588498
10Cell cycle_Homo sapiens_hsa041103.10856220
11Nicotine addiction_Homo sapiens_hsa050333.10033745
12Nucleotide excision repair_Homo sapiens_hsa034203.06731131
13Homologous recombination_Homo sapiens_hsa034403.01633231
14RNA polymerase_Homo sapiens_hsa030202.92973660
15Non-homologous end-joining_Homo sapiens_hsa034502.68645969
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.43339810
17Fanconi anemia pathway_Homo sapiens_hsa034602.43307663
18mRNA surveillance pathway_Homo sapiens_hsa030152.32442367
19One carbon pool by folate_Homo sapiens_hsa006702.31340994
20Pyrimidine metabolism_Homo sapiens_hsa002402.20742152
21Dorso-ventral axis formation_Homo sapiens_hsa043202.18780604
22RNA degradation_Homo sapiens_hsa030182.10795358
23Ribosome_Homo sapiens_hsa030102.07790790
24Proteasome_Homo sapiens_hsa030502.06151510
25Basal transcription factors_Homo sapiens_hsa030222.05017673
26Sphingolipid metabolism_Homo sapiens_hsa006001.97550376
27Taste transduction_Homo sapiens_hsa047421.89890509
28Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.71704820
29Morphine addiction_Homo sapiens_hsa050321.68251538
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68098171
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67947155
32Systemic lupus erythematosus_Homo sapiens_hsa053221.55171588
33p53 signaling pathway_Homo sapiens_hsa041151.47514856
34Butanoate metabolism_Homo sapiens_hsa006501.42004946
35Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27856032
36Oocyte meiosis_Homo sapiens_hsa041141.27055195
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.20359863
38Purine metabolism_Homo sapiens_hsa002301.18935203
39GABAergic synapse_Homo sapiens_hsa047271.17852196
40Epstein-Barr virus infection_Homo sapiens_hsa051691.17431576
41Tryptophan metabolism_Homo sapiens_hsa003801.15645128
42Viral carcinogenesis_Homo sapiens_hsa052031.14014935
43Propanoate metabolism_Homo sapiens_hsa006401.11686305
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08431447
45Calcium signaling pathway_Homo sapiens_hsa040201.05882424
46Histidine metabolism_Homo sapiens_hsa003401.05330841
47Alcoholism_Homo sapiens_hsa050341.03546180
48Olfactory transduction_Homo sapiens_hsa047401.02369303
49Serotonergic synapse_Homo sapiens_hsa047261.02099998
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98405286
51Colorectal cancer_Homo sapiens_hsa052100.96567760
52Nitrogen metabolism_Homo sapiens_hsa009100.92715795
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90058884
54Basal cell carcinoma_Homo sapiens_hsa052170.89948967
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89525746
56MicroRNAs in cancer_Homo sapiens_hsa052060.89414534
57HTLV-I infection_Homo sapiens_hsa051660.85665724
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84000086
59N-Glycan biosynthesis_Homo sapiens_hsa005100.82436798
60Glutamatergic synapse_Homo sapiens_hsa047240.80916476
61alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.80823981
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80798949
63Notch signaling pathway_Homo sapiens_hsa043300.79834374
64Thyroid cancer_Homo sapiens_hsa052160.79444049
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77527461
66Linoleic acid metabolism_Homo sapiens_hsa005910.77281890
67Hippo signaling pathway_Homo sapiens_hsa043900.76749282
68Herpes simplex infection_Homo sapiens_hsa051680.75994962
69Vitamin digestion and absorption_Homo sapiens_hsa049770.74932307
70Protein export_Homo sapiens_hsa030600.73256242
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71873068
72Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71443455
73Pyruvate metabolism_Homo sapiens_hsa006200.68576362
74Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68562631
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68122468
76ABC transporters_Homo sapiens_hsa020100.67908901
77Antigen processing and presentation_Homo sapiens_hsa046120.67688160
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66321155
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.66008307
80Glycerolipid metabolism_Homo sapiens_hsa005610.65932288
81Hedgehog signaling pathway_Homo sapiens_hsa043400.65803311
82Ovarian steroidogenesis_Homo sapiens_hsa049130.62478112
83Endometrial cancer_Homo sapiens_hsa052130.62419669
84cAMP signaling pathway_Homo sapiens_hsa040240.59676511
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58251471
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58075779
87Chronic myeloid leukemia_Homo sapiens_hsa052200.57616875
88Wnt signaling pathway_Homo sapiens_hsa043100.56904201
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.54401179
90TGF-beta signaling pathway_Homo sapiens_hsa043500.53650687
91Ether lipid metabolism_Homo sapiens_hsa005650.53209501
92Small cell lung cancer_Homo sapiens_hsa052220.53132044
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52317180
94Phenylalanine metabolism_Homo sapiens_hsa003600.49962983
95beta-Alanine metabolism_Homo sapiens_hsa004100.49687793
96Central carbon metabolism in cancer_Homo sapiens_hsa052300.49126359
97Non-small cell lung cancer_Homo sapiens_hsa052230.46313185
98Bladder cancer_Homo sapiens_hsa052190.43128320
99Salivary secretion_Homo sapiens_hsa049700.43099140
100Hepatitis B_Homo sapiens_hsa051610.41559050
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41409226
102Folate biosynthesis_Homo sapiens_hsa007900.40075974
103Pancreatic cancer_Homo sapiens_hsa052120.40034399
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39975567
105Cholinergic synapse_Homo sapiens_hsa047250.39605668
106Pathways in cancer_Homo sapiens_hsa052000.39026003
107Selenocompound metabolism_Homo sapiens_hsa004500.38401634
108Biosynthesis of amino acids_Homo sapiens_hsa012300.37053193
109Lysine degradation_Homo sapiens_hsa003100.36823141
110mTOR signaling pathway_Homo sapiens_hsa041500.36080000
111Adherens junction_Homo sapiens_hsa045200.35606916
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34175704
113Apoptosis_Homo sapiens_hsa042100.34134681
114Metabolic pathways_Homo sapiens_hsa011000.33688477
115Pentose phosphate pathway_Homo sapiens_hsa000300.33648285
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.33538749
117Circadian entrainment_Homo sapiens_hsa047130.33024475
118Fatty acid degradation_Homo sapiens_hsa000710.31751971
119Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31084381
120Prostate cancer_Homo sapiens_hsa052150.31082477
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30126569
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.27937137
123Melanogenesis_Homo sapiens_hsa049160.27318676
124Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27091699
125Melanoma_Homo sapiens_hsa052180.26149319
126Long-term depression_Homo sapiens_hsa047300.25362206
127Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25220262
128FoxO signaling pathway_Homo sapiens_hsa040680.23208461
129Acute myeloid leukemia_Homo sapiens_hsa052210.22351630
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.22228905
131Sphingolipid signaling pathway_Homo sapiens_hsa040710.21789955
132Peroxisome_Homo sapiens_hsa041460.20667247
133Arachidonic acid metabolism_Homo sapiens_hsa005900.20344205
134Tight junction_Homo sapiens_hsa045300.19725451
135Huntingtons disease_Homo sapiens_hsa050160.19420119
136Shigellosis_Homo sapiens_hsa051310.19257320
137Legionellosis_Homo sapiens_hsa051340.19065814
138Neurotrophin signaling pathway_Homo sapiens_hsa047220.18438990
139Viral myocarditis_Homo sapiens_hsa054160.17345122
140Tyrosine metabolism_Homo sapiens_hsa003500.16583113
141Maturity onset diabetes of the young_Homo sapiens_hsa049500.15619879
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.14727867
143Galactose metabolism_Homo sapiens_hsa000520.14060004
144Fructose and mannose metabolism_Homo sapiens_hsa000510.13656452
145Renin-angiotensin system_Homo sapiens_hsa046140.12270787
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11882787
147VEGF signaling pathway_Homo sapiens_hsa043700.11856275
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.11756156
149Primary immunodeficiency_Homo sapiens_hsa053400.10377674
150PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10247604
151B cell receptor signaling pathway_Homo sapiens_hsa046620.10138032
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.09712995
153Glutathione metabolism_Homo sapiens_hsa004800.08936936
154Influenza A_Homo sapiens_hsa051640.08763521
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.06454142
156Sulfur relay system_Homo sapiens_hsa041220.06330348
157Vitamin B6 metabolism_Homo sapiens_hsa007500.05506751

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