CEP68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.83430188
2mitotic sister chromatid cohesion (GO:0007064)4.96347341
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.76048296
4negative regulation of histone methylation (GO:0031061)4.62614190
5presynaptic membrane assembly (GO:0097105)4.34844313
6pyrimidine nucleobase catabolic process (GO:0006208)4.31229482
7regulation of histone H3-K9 methylation (GO:0051570)4.28442284
8nuclear pore complex assembly (GO:0051292)4.18581717
9nuclear pore organization (GO:0006999)3.95637782
10protein localization to kinetochore (GO:0034501)3.93507318
11negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.88385324
12postsynaptic membrane organization (GO:0001941)3.81510600
13pre-miRNA processing (GO:0031054)3.80628550
14mitotic chromosome condensation (GO:0007076)3.74007150
15IMP biosynthetic process (GO:0006188)3.73863896
16negative regulation of RNA splicing (GO:0033119)3.72805944
17presynaptic membrane organization (GO:0097090)3.70438495
18dendritic spine morphogenesis (GO:0060997)3.67421156
19DNA duplex unwinding (GO:0032508)3.65780533
20DNA geometric change (GO:0032392)3.61751708
21regulation of sarcomere organization (GO:0060297)3.55380213
22dosage compensation (GO:0007549)3.52841069
23behavioral response to nicotine (GO:0035095)3.45293145
24DNA strand elongation involved in DNA replication (GO:0006271)3.43934637
25DNA replication initiation (GO:0006270)3.39255794
26nucleobase catabolic process (GO:0046113)3.39084703
27neuron cell-cell adhesion (GO:0007158)3.35170708
28peptidyl-lysine dimethylation (GO:0018027)3.34401548
29IMP metabolic process (GO:0046040)3.34275304
30translesion synthesis (GO:0019985)3.31390883
31DNA topological change (GO:0006265)3.31166682
32negative regulation of mRNA processing (GO:0050686)3.29419600
33cardiac myofibril assembly (GO:0055003)3.28759551
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.28573175
35pore complex assembly (GO:0046931)3.27474292
36positive regulation of B cell differentiation (GO:0045579)3.26329993
37DNA strand elongation (GO:0022616)3.24696751
38protein localization to chromosome, centromeric region (GO:0071459)3.23733425
39gamma-aminobutyric acid transport (GO:0015812)3.23131971
40glucocorticoid receptor signaling pathway (GO:0042921)3.21391606
41regulation of DNA endoreduplication (GO:0032875)3.18763110
42mitotic nuclear envelope disassembly (GO:0007077)3.17146776
43neuronal action potential propagation (GO:0019227)3.16560436
44negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.11795849
45negative regulation of translation, ncRNA-mediated (GO:0040033)3.11795849
46regulation of translation, ncRNA-mediated (GO:0045974)3.11795849
47negative regulation of cytosolic calcium ion concentration (GO:0051481)3.11562116
48alternative mRNA splicing, via spliceosome (GO:0000380)3.10768474
49negative regulation of histone modification (GO:0031057)3.10533488
50negative regulation of mRNA metabolic process (GO:1903312)3.09687313
51definitive hemopoiesis (GO:0060216)3.08868436
52regulation of relaxation of muscle (GO:1901077)3.05582533
53positive regulation of SMAD protein import into nucleus (GO:0060391)3.03993421
54vocalization behavior (GO:0071625)3.01346293
55regulation of translational fidelity (GO:0006450)3.01046051
56regulation of sister chromatid cohesion (GO:0007063)3.00642255
57DNA conformation change (GO:0071103)2.98896174
58central nervous system projection neuron axonogenesis (GO:0021952)2.98645261
59nonmotile primary cilium assembly (GO:0035058)2.98565856
60neural tube formation (GO:0001841)2.97072544
61chromatin assembly (GO:0031497)2.96009511
62neurotransmitter-gated ion channel clustering (GO:0072578)2.95637309
63membrane disassembly (GO:0030397)2.92484439
64nuclear envelope disassembly (GO:0051081)2.92484439
65negative regulation of chromatin modification (GO:1903309)2.91391956
66sister chromatid segregation (GO:0000819)2.87501721
67ribosomal small subunit assembly (GO:0000028)2.87309336
68forebrain neuron differentiation (GO:0021879)2.87186068
69neuronal stem cell maintenance (GO:0097150)2.85890313
70regulation of RNA export from nucleus (GO:0046831)2.84392453
71neuromuscular synaptic transmission (GO:0007274)2.84356767
72membrane depolarization during action potential (GO:0086010)2.81781755
73telomere maintenance via semi-conservative replication (GO:0032201)2.81771009
74retinal cone cell development (GO:0046549)2.81282846
75mechanosensory behavior (GO:0007638)2.81217896
76synaptic vesicle maturation (GO:0016188)2.80836247
77sarcomere organization (GO:0045214)2.80258621
78auditory behavior (GO:0031223)2.79732520
79regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79663442
80mRNA stabilization (GO:0048255)2.78277371
81RNA stabilization (GO:0043489)2.78277371
82mitotic recombination (GO:0006312)2.78148108
83negative regulation of gene expression, epigenetic (GO:0045814)2.76793187
84regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.74593377
85histone H2A monoubiquitination (GO:0035518)2.74498851
86somite development (GO:0061053)2.74214456
87cytoplasmic mRNA processing body assembly (GO:0033962)2.73554352
88folic acid-containing compound biosynthetic process (GO:0009396)2.72767206
89kinetochore organization (GO:0051383)2.72756265
90positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.72491882
91central nervous system neuron axonogenesis (GO:0021955)2.70891777
92detection of light stimulus involved in sensory perception (GO:0050962)2.70145020
93detection of light stimulus involved in visual perception (GO:0050908)2.70145020
94DNA replication-dependent nucleosome assembly (GO:0006335)2.69835424
95DNA replication-dependent nucleosome organization (GO:0034723)2.69835424
963-UTR-mediated mRNA stabilization (GO:0070935)2.69516130
97regulation of skeletal muscle contraction (GO:0014819)2.67152951
98postreplication repair (GO:0006301)2.66688709
99epithelial cell differentiation involved in kidney development (GO:0035850)2.66561319
100positive regulation of gamma-delta T cell activation (GO:0046645)2.66386962
101transmission of nerve impulse (GO:0019226)2.66029111
102chromatin assembly or disassembly (GO:0006333)2.65797287
103protein-DNA complex disassembly (GO:0032986)2.64180269
104nucleosome disassembly (GO:0006337)2.64180269
105regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.63853355
106monoubiquitinated protein deubiquitination (GO:0035520)2.63800281
107heterochromatin organization (GO:0070828)2.63686889
108interkinetic nuclear migration (GO:0022027)2.63371541
109regulation of mRNA stability (GO:0043488)2.62600902
110regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.61552040
111protein localization to synapse (GO:0035418)2.61319623
112corticosteroid receptor signaling pathway (GO:0031958)2.61236981
113myofibril assembly (GO:0030239)2.60673088
114regulation of gene silencing (GO:0060968)2.60317746
115regulation of centriole replication (GO:0046599)2.60293351
116dentate gyrus development (GO:0021542)2.59865575
117negative regulation of histone acetylation (GO:0035067)2.59392007
118regulation of development, heterochronic (GO:0040034)2.58976953
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.58719945
120synapse assembly (GO:0007416)2.58350086
121regulation of histone methylation (GO:0031060)2.57904027
122regulation of respiratory system process (GO:0044065)2.57434437
123positive regulation of chromosome segregation (GO:0051984)2.56946420
124telomere maintenance via recombination (GO:0000722)2.56939825
125chemosensory behavior (GO:0007635)2.56919325
126detection of calcium ion (GO:0005513)2.56108374
127embryonic hemopoiesis (GO:0035162)2.55939641
128negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.54921358
129nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.54704457
130ionotropic glutamate receptor signaling pathway (GO:0035235)2.54492569
131positive regulation of microtubule polymerization (GO:0031116)2.53994773
132regulation of DNA damage checkpoint (GO:2000001)2.53929946
133glycosphingolipid biosynthetic process (GO:0006688)2.53689664
134regulation of collateral sprouting (GO:0048670)2.53397577
135regulation of SMAD protein import into nucleus (GO:0060390)2.52753548
136detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52664784
137regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.52359916
138protein polyglutamylation (GO:0018095)2.52267796
139histone H2A acetylation (GO:0043968)2.51783151
140positive regulation of protein homodimerization activity (GO:0090073)2.51750040
141positive regulation of histone deacetylation (GO:0031065)2.51149389
142regulation of histone H3-K4 methylation (GO:0051569)2.50955428
143spliceosomal tri-snRNP complex assembly (GO:0000244)2.50905132
144cerebellar Purkinje cell differentiation (GO:0021702)2.50418319
145regulation of dendritic spine morphogenesis (GO:0061001)2.50345109
146positive regulation of gene expression, epigenetic (GO:0045815)2.49800036
147antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.49245434
148viral transcription (GO:0019083)2.49142184
149attachment of spindle microtubules to kinetochore (GO:0008608)2.48750194
150chromosome condensation (GO:0030261)2.47965870
151protein import into peroxisome matrix (GO:0016558)2.47902680
152regulation of spindle organization (GO:0090224)2.47876101
153microtubule severing (GO:0051013)2.47856205
154regulation of gene silencing by RNA (GO:0060966)2.47524021
155regulation of posttranscriptional gene silencing (GO:0060147)2.47524021
156regulation of gene silencing by miRNA (GO:0060964)2.47524021
157meiotic chromosome segregation (GO:0045132)2.47485173
158axonal fasciculation (GO:0007413)2.47162670
159negative regulation of cell cycle G2/M phase transition (GO:1902750)2.46133147
160regulation of cell communication by electrical coupling (GO:0010649)2.46014594
161NLS-bearing protein import into nucleus (GO:0006607)2.45802194
162inositol phosphate catabolic process (GO:0071545)2.45656813
163regulation of timing of cell differentiation (GO:0048505)2.45120593
164sister chromatid cohesion (GO:0007062)2.44046208
165positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.44045162
166positive regulation of histone H3-K4 methylation (GO:0051571)2.43721589
167regulation of gamma-delta T cell differentiation (GO:0045586)2.43628360
168glutamate receptor signaling pathway (GO:0007215)2.43133410
169pyrimidine dimer repair (GO:0006290)2.42669341
170photoreceptor cell maintenance (GO:0045494)2.42664544
171synaptic transmission, cholinergic (GO:0007271)2.40774226
172positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.38218821
173neuron-neuron synaptic transmission (GO:0007270)2.38075234
174negative regulation of neurotransmitter transport (GO:0051589)2.37215395
175cardiac ventricle formation (GO:0003211)2.36709210
176regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.36521433
177sarcoplasmic reticulum calcium ion transport (GO:0070296)2.35598489
178synaptic transmission, glutamatergic (GO:0035249)2.34016416
179spinal cord association neuron differentiation (GO:0021527)2.33676263
180establishment of mitochondrion localization (GO:0051654)2.33573188
181neuronal action potential (GO:0019228)2.33043059
182G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32327658
183regulation of respiratory gaseous exchange (GO:0043576)2.31948520
184regulation of cilium movement (GO:0003352)2.30444931
185regulation of glutamate receptor signaling pathway (GO:1900449)2.29011378
186response to inactivity (GO:0014854)2.28973466
187regulation of synaptic vesicle exocytosis (GO:2000300)2.28515919
188positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.27672142
189cerebral cortex radially oriented cell migration (GO:0021799)2.27667454
190protein prenylation (GO:0018342)2.27444022
191prenylation (GO:0097354)2.27444022
192actin-myosin filament sliding (GO:0033275)2.27362767
193muscle filament sliding (GO:0030049)2.27362767
194regulation of excitatory postsynaptic membrane potential (GO:0060079)2.23931297
195positive regulation of mitochondrial fission (GO:0090141)2.23866406
196regulation of pigment cell differentiation (GO:0050932)2.23381309
197intraciliary transport (GO:0042073)2.22719814
198cilium morphogenesis (GO:0060271)2.22252843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.66899895
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.61440983
3EZH2_22144423_ChIP-Seq_EOC_Human4.34249334
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.86991879
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.69865831
6MYC_22102868_ChIP-Seq_BL_Human3.60375440
7GBX2_23144817_ChIP-Seq_PC3_Human3.51903853
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.43414832
9IGF1R_20145208_ChIP-Seq_DFB_Human3.31027818
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.76127346
11ZNF274_21170338_ChIP-Seq_K562_Hela2.74535625
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.74017530
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72548080
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67820932
15TAF15_26573619_Chip-Seq_HEK293_Human2.66388383
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62389593
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.53521929
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51575886
19FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.45102240
20CIITA_25753668_ChIP-Seq_RAJI_Human2.43491274
21GATA1_22025678_ChIP-Seq_K562_Human2.41358837
22* SCL_19346495_ChIP-Seq_HPC-7_Human2.40033608
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.39117264
24FUS_26573619_Chip-Seq_HEK293_Human2.31573269
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26873400
26VDR_21846776_ChIP-Seq_THP-1_Human2.22201852
27* E2F1_21310950_ChIP-Seq_MCF-7_Human2.21638350
28P300_19829295_ChIP-Seq_ESCs_Human2.08225950
29EWS_26573619_Chip-Seq_HEK293_Human2.07399278
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07157578
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05366551
32MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04791972
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03570944
34SALL1_21062744_ChIP-ChIP_HESCs_Human2.02174774
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95826535
36VDR_22108803_ChIP-Seq_LS180_Human1.94033337
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92044441
38TCF7_22412390_ChIP-Seq_EML_Mouse1.90707664
39* REST_21632747_ChIP-Seq_MESCs_Mouse1.89091814
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.88150918
41* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.85369968
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83366522
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80171241
44FLI1_27457419_Chip-Seq_LIVER_Mouse1.79304192
45AR_21909140_ChIP-Seq_LNCAP_Human1.79253751
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.79170801
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.76198684
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.75963290
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.75316808
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75316808
51* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75227019
52SMAD4_21799915_ChIP-Seq_A2780_Human1.73693728
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70485845
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70187079
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.69615246
56AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.67605762
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65559819
58AR_21572438_ChIP-Seq_LNCaP_Human1.64690546
59ER_23166858_ChIP-Seq_MCF-7_Human1.63061305
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.62261865
61PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61892193
62RNF2_27304074_Chip-Seq_NSC_Mouse1.60584888
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.58677823
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57073508
65RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55896376
66YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54957039
67SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53403350
68MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52313346
69OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52028110
70HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50901119
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.47972955
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.47880674
73MAF_26560356_Chip-Seq_TH1_Human1.47266298
74* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46737255
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45899280
76XRN2_22483619_ChIP-Seq_HELA_Human1.45773606
77STAT3_23295773_ChIP-Seq_U87_Human1.44926792
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.44615319
79* UTX_26944678_Chip-Seq_JUKART_Human1.42963164
80TCF4_23295773_ChIP-Seq_U87_Human1.41839070
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41326650
82CBP_20019798_ChIP-Seq_JUKART_Human1.41326650
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.41183941
84IRF1_19129219_ChIP-ChIP_H3396_Human1.40634391
85* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39018037
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38767607
87* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38257451
88* REST_18959480_ChIP-ChIP_MESCs_Mouse1.38257399
89* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.38138687
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.37877785
91SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35802264
92* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35136725
93* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.33209796
94EZH2_27304074_Chip-Seq_ESCs_Mouse1.32934618
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32912958
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32866943
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32673345
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32503560
99SMAD3_21741376_ChIP-Seq_EPCs_Human1.32026318
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.31964600
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.31806122
102* MYB_26560356_Chip-Seq_TH1_Human1.31285759
103AR_25329375_ChIP-Seq_VCAP_Human1.30767550
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30712526
105KDM2B_26808549_Chip-Seq_DND41_Human1.30358378
106HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30135209
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29954275
108VDR_24763502_ChIP-Seq_THP-1_Human1.29579458
109FOXP3_21729870_ChIP-Seq_TREG_Human1.29257993
110JARID2_20064375_ChIP-Seq_MESCs_Mouse1.29025374
111SOX2_21211035_ChIP-Seq_LN229_Gbm1.26960969
112* MYB_26560356_Chip-Seq_TH2_Human1.26805792
113CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23224747
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23216404
115* FLI1_21867929_ChIP-Seq_TH2_Mouse1.22966506
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.22879641
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22412672
118KDM5A_27292631_Chip-Seq_BREAST_Human1.20798000
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20575548
120NANOG_18555785_Chip-Seq_ESCs_Mouse1.20505765
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19958610
122POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19259542
123RUNX2_22187159_ChIP-Seq_PCA_Human1.19199595
124BCAT_22108803_ChIP-Seq_LS180_Human1.18843397
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18299380
126* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18133217
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.18115414
128SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15939759
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15655758
130TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15387375
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14644317
132E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.14582814
133EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.12328627
134NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12262328
135MYB_21317192_ChIP-Seq_ERMYB_Mouse1.12249680
136* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12242090
137TTF2_22483619_ChIP-Seq_HELA_Human1.12218560
138* SPI1_23547873_ChIP-Seq_NB4_Human1.12086319
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.11730061
140VDR_23849224_ChIP-Seq_CD4+_Human1.11270371
141CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10391798
142ELK3_25401928_ChIP-Seq_HUVEC_Human1.10215092
143DROSHA_22980978_ChIP-Seq_HELA_Human1.10214586
144PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10049168
145SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.09214317
146GATA4_21415370_ChIP-Seq_HL-1_Mouse1.08738519
147TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08278410
148FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07832002
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.07176658
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07113928
151POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07113685
152KDM2B_26808549_Chip-Seq_REH_Human1.06470688
153SOX9_26525672_Chip-Seq_HEART_Mouse1.06291040
154RUNX1_22412390_ChIP-Seq_EML_Mouse1.05850902
155DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05464854
156STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05366221
157ZNF263_19887448_ChIP-Seq_K562_Human1.05222269
158P53_22387025_ChIP-Seq_ESCs_Mouse1.05059668
159* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05023154
160POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.05005650
161EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04783625
162TP53_22573176_ChIP-Seq_HFKS_Human1.03351182
163* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03197630
164BRD4_27068464_Chip-Seq_AML-cells_Mouse1.03160906
165ELK1_19687146_ChIP-ChIP_HELA_Human1.02857428
166STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01736398
167PRDM14_20953172_ChIP-Seq_ESCs_Human1.01259340
168MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00797026
169BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00763985
170SPI1_23127762_ChIP-Seq_K562_Human0.99905257
171EST1_17652178_ChIP-ChIP_JURKAT_Human0.99164659
172BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99065638
173PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.98505402
174* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98387423
175RNF2_27304074_Chip-Seq_ESCs_Mouse0.98315100
176TFEB_21752829_ChIP-Seq_HELA_Human0.98292074
177NFE2_27457419_Chip-Seq_LIVER_Mouse0.97830279
178E2F1_18555785_Chip-Seq_ESCs_Mouse0.97694403
179NANOG_19829295_ChIP-Seq_ESCs_Human0.97525463
180SOX2_19829295_ChIP-Seq_ESCs_Human0.97525463
181SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97140076
182EZH2_27294783_Chip-Seq_ESCs_Mouse0.96924705
183TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95414652
184NOTCH1_21737748_ChIP-Seq_TLL_Human0.95358884
185SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95081437
186NANOG_21062744_ChIP-ChIP_HESCs_Human0.94536974
187* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93689943
188CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.93434979
189RUNX_20019798_ChIP-Seq_JUKART_Human0.93047022
190KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92125101
191E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91682331
192IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91113690
193FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90616452
194ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88629249
195CHD1_26751641_Chip-Seq_LNCaP_Human0.88287205

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.57003887
2MP0003787_abnormal_imprinting3.30071050
3MP0010094_abnormal_chromosome_stability2.94215117
4MP0004808_abnormal_hematopoietic_stem2.89609415
5MP0004084_abnormal_cardiac_muscle2.86012248
6MP0003880_abnormal_central_pattern2.81344524
7MP0006276_abnormal_autonomic_nervous2.41397534
8MP0003077_abnormal_cell_cycle2.40087600
9MP0008057_abnormal_DNA_replication2.35653397
10MP0002638_abnormal_pupillary_reflex2.35517311
11MP0003567_abnormal_fetal_cardiomyocyte2.31414100
12MP0004859_abnormal_synaptic_plasticity2.24233083
13MP0003122_maternal_imprinting2.23224856
14MP0008007_abnormal_cellular_replicative2.19991862
15MP0001984_abnormal_olfaction2.16948688
16MP0003111_abnormal_nucleus_morphology2.11195102
17MP0010352_gastrointestinal_tract_polyps2.05158981
18MP0003635_abnormal_synaptic_transmissio2.03846424
19MP0009278_abnormal_bone_marrow2.02534343
20MP0010368_abnormal_lymphatic_system2.01713846
21MP0000778_abnormal_nervous_system1.98871590
22MP0002102_abnormal_ear_morphology1.94976312
23MP0010630_abnormal_cardiac_muscle1.93023060
24MP0005645_abnormal_hypothalamus_physiol1.91904229
25MP0004957_abnormal_blastocyst_morpholog1.90179057
26MP0004215_abnormal_myocardial_fiber1.89582192
27MP0004270_analgesia1.83895378
28MP0002272_abnormal_nervous_system1.82121590
29MP0003195_calcinosis1.81308965
30MP0004036_abnormal_muscle_relaxation1.80279760
31MP0003828_pulmonary_edema1.79441306
32MP0003693_abnormal_embryo_hatching1.77872218
33MP0000569_abnormal_digit_pigmentation1.77862444
34MP0001968_abnormal_touch/_nociception1.73889885
35MP0003705_abnormal_hypodermis_morpholog1.73567614
36MP0002063_abnormal_learning/memory/cond1.71742849
37MP0009745_abnormal_behavioral_response1.70085076
38MP0002736_abnormal_nociception_after1.69444489
39MP0002837_dystrophic_cardiac_calcinosis1.69324091
40MP0001486_abnormal_startle_reflex1.69205961
41MP0003646_muscle_fatigue1.67603844
42MP0004233_abnormal_muscle_weight1.67591208
43MP0010307_abnormal_tumor_latency1.66767738
44MP0003984_embryonic_growth_retardation1.64652238
45MP0002088_abnormal_embryonic_growth/wei1.63650167
46MP0001730_embryonic_growth_arrest1.63415814
47MP0004087_abnormal_muscle_fiber1.61215167
48MP0009046_muscle_twitch1.59656853
49MP0002572_abnormal_emotion/affect_behav1.54261578
50MP0000350_abnormal_cell_proliferation1.54039696
51MP0008877_abnormal_DNA_methylation1.53997532
52MP0001672_abnormal_embryogenesis/_devel1.53896824
53MP0005380_embryogenesis_phenotype1.53896824
54MP0006292_abnormal_olfactory_placode1.52804373
55MP0004142_abnormal_muscle_tone1.52731930
56MP0002064_seizures1.51328752
57MP0005076_abnormal_cell_differentiation1.51022685
58MP0002067_abnormal_sensory_capabilities1.50431533
59MP0003121_genomic_imprinting1.50234279
60MP0006054_spinal_hemorrhage1.49897686
61MP0000751_myopathy1.49628026
62MP0000733_abnormal_muscle_development1.49474218
63MP0005253_abnormal_eye_physiology1.49257244
64MP0001529_abnormal_vocalization1.48931440
65MP0002735_abnormal_chemical_nociception1.47410001
66MP0005423_abnormal_somatic_nervous1.47290087
67MP0004130_abnormal_muscle_cell1.46970946
68MP0002734_abnormal_mechanical_nocicepti1.46059376
69MP0001545_abnormal_hematopoietic_system1.45328146
70MP0005397_hematopoietic_system_phenotyp1.45328146
71MP0005551_abnormal_eye_electrophysiolog1.44724393
72MP0008058_abnormal_DNA_repair1.43719330
73MP0005330_cardiomyopathy1.43207367
74MP0003763_abnormal_thymus_physiology1.41455235
75MP0001697_abnormal_embryo_size1.41180584
76MP0004197_abnormal_fetal_growth/weight/1.39467902
77MP0000703_abnormal_thymus_morphology1.39258750
78MP0008789_abnormal_olfactory_epithelium1.38331911
79MP0001879_abnormal_lymphatic_vessel1.36734154
80MP0005646_abnormal_pituitary_gland1.36644300
81MP0006072_abnormal_retinal_apoptosis1.35882101
82MP0002398_abnormal_bone_marrow1.35747724
83MP0002086_abnormal_extraembryonic_tissu1.35714926
84MP0004133_heterotaxia1.35309825
85MP0003279_aneurysm1.34442069
86MP0002166_altered_tumor_susceptibility1.34167676
87MP0005394_taste/olfaction_phenotype1.34074494
88MP0005499_abnormal_olfactory_system1.34074494
89MP0002653_abnormal_ependyma_morphology1.32027599
90MP0001986_abnormal_taste_sensitivity1.31661836
91MP0005167_abnormal_blood-brain_barrier1.31583165
92MP0001188_hyperpigmentation1.31415451
93MP0004924_abnormal_behavior1.30969756
94MP0005386_behavior/neurological_phenoty1.30969756
95MP0002106_abnormal_muscle_physiology1.27835758
96MP0002084_abnormal_developmental_patter1.27779371
97MP0000266_abnormal_heart_morphology1.27655267
98MP0003123_paternal_imprinting1.27450731
99MP0005670_abnormal_white_adipose1.25081276
100MP0008995_early_reproductive_senescence1.24246358
101MP0002080_prenatal_lethality1.23369529
102MP0005666_abnormal_adipose_tissue1.23153780
103MP0001544_abnormal_cardiovascular_syste1.22409093
104MP0005385_cardiovascular_system_phenoty1.22409093
105MP0004043_abnormal_pH_regulation1.20643316
106MP0003136_yellow_coat_color1.20259118
107MP0002925_abnormal_cardiovascular_devel1.19615379
108MP0001501_abnormal_sleep_pattern1.19226183
109MP0002269_muscular_atrophy1.18152453
110MP0001915_intracranial_hemorrhage1.17577753
111MP0000631_abnormal_neuroendocrine_gland1.16846285
112MP0002085_abnormal_embryonic_tissue1.16078401
113MP0000689_abnormal_spleen_morphology1.15564337
114MP0002722_abnormal_immune_system1.13485992
115MP0002557_abnormal_social/conspecific_i1.11926896
116MP0003300_gastrointestinal_ulcer1.11922368
117MP0004885_abnormal_endolymph1.11115719
118MP0006138_congestive_heart_failure1.10396553
119MP0000465_gastrointestinal_hemorrhage1.09016242
120MP0005187_abnormal_penis_morphology1.08196401
121MP0004811_abnormal_neuron_physiology1.06666637
122MP0004145_abnormal_muscle_electrophysio1.06425595
123MP0002972_abnormal_cardiac_muscle1.05743439
124MP0002822_catalepsy1.04553002
125MP0002882_abnormal_neuron_morphology1.04183063
126MP0000749_muscle_degeneration1.03594883
127MP0000955_abnormal_spinal_cord1.03420660
128MP0001970_abnormal_pain_threshold1.02590085
129MP0008569_lethality_at_weaning1.02465755
130MP0003566_abnormal_cell_adhesion1.01536027
131MP0008961_abnormal_basal_metabolism1.00471016
132MP0003221_abnormal_cardiomyocyte_apopto0.99894556
133MP0002752_abnormal_somatic_nervous0.98632326
134MP0002128_abnormal_blood_circulation0.98595944
135MP0002733_abnormal_thermal_nociception0.98464912
136MP0000750_abnormal_muscle_regeneration0.98086400
137MP0002019_abnormal_tumor_incidence0.96653656
138MP0002127_abnormal_cardiovascular_syste0.96518357
139MP0005369_muscle_phenotype0.95816415
140MP0000313_abnormal_cell_death0.95439971
141MP0002751_abnormal_autonomic_nervous0.93878187
142MP0002160_abnormal_reproductive_system0.93869557
143MP0001800_abnormal_humoral_immune0.93793672
144MP0002184_abnormal_innervation0.93620441
145MP0002152_abnormal_brain_morphology0.93191423
146MP0000759_abnormal_skeletal_muscle0.93028087
147MP0010234_abnormal_vibrissa_follicle0.92453493
148MP0000490_abnormal_crypts_of0.92450456
149MP0004484_altered_response_of0.92405630
150MP0002429_abnormal_blood_cell0.91642902
151MP0005375_adipose_tissue_phenotype0.91288106
152MP0005174_abnormal_tail_pigmentation0.91203008
153MP0003137_abnormal_impulse_conducting0.90886060
154MP0003890_abnormal_embryonic-extraembry0.90808131
155MP0003943_abnormal_hepatobiliary_system0.89495558
156MP0001485_abnormal_pinna_reflex0.89160680
157MP0004185_abnormal_adipocyte_glucose0.87298782
158MP0000372_irregular_coat_pigmentation0.86141178
159MP0009672_abnormal_birth_weight0.86067268
160MP0000747_muscle_weakness0.85973683
161MP0000716_abnormal_immune_system0.85666288
162MP0001177_atelectasis0.85125150
163MP0002075_abnormal_coat/hair_pigmentati0.84852428
164MP0002234_abnormal_pharynx_morphology0.84368242
165MP0005620_abnormal_muscle_contractility0.84152904
166MP0000013_abnormal_adipose_tissue0.84131117
167MP0000767_abnormal_smooth_muscle0.83905537
168MP0002006_tumorigenesis0.83660458
169MP0002066_abnormal_motor_capabilities/c0.83229424
170MP0004085_abnormal_heartbeat0.82787206
171MP0005195_abnormal_posterior_eye0.82405337
172MP0001502_abnormal_circadian_rhythm0.82214746
173MP0003633_abnormal_nervous_system0.81132870
174MP0002108_abnormal_muscle_morphology0.80860585
175MP0005171_absent_coat_pigmentation0.80159822
176MP0001293_anophthalmia0.80050978

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.60072286
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.60072286
3Febrile seizures (HP:0002373)3.54776021
4Focal motor seizures (HP:0011153)3.34359978
5Abnormality of the left ventricular outflow tract (HP:0011103)3.30407955
6Subaortic stenosis (HP:0001682)3.30407955
7Thrombocytosis (HP:0001894)3.29953764
8Ependymoma (HP:0002888)3.25607195
9Volvulus (HP:0002580)3.18592361
10Abnormality of the fingertips (HP:0001211)3.14050151
11Abnormality of the 4th metacarpal (HP:0010012)3.05722973
12Colon cancer (HP:0003003)3.01202660
13Neoplasm of the oral cavity (HP:0100649)2.97212029
14Hyperacusis (HP:0010780)2.87995827
15Broad-based gait (HP:0002136)2.83362304
16Hepatoblastoma (HP:0002884)2.79316133
17Medulloblastoma (HP:0002885)2.78312725
18Pancreatic cysts (HP:0001737)2.75069465
19Focal seizures (HP:0007359)2.72640160
20Muscle fiber inclusion bodies (HP:0100299)2.71077193
21Pancreatic fibrosis (HP:0100732)2.70556431
22Abnormality of the labia minora (HP:0012880)2.68168701
23Increased nuchal translucency (HP:0010880)2.66309000
24Hyperventilation (HP:0002883)2.64604154
25Nemaline bodies (HP:0003798)2.60904856
26True hermaphroditism (HP:0010459)2.59509128
27Medial flaring of the eyebrow (HP:0010747)2.58690505
28Amaurosis fugax (HP:0100576)2.56334956
29Sudden death (HP:0001699)2.55808707
30Exercise-induced muscle cramps (HP:0003710)2.55487429
31Progressive cerebellar ataxia (HP:0002073)2.54564284
32Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.53751726
33Long eyelashes (HP:0000527)2.53521893
34Muscle hypertrophy of the lower extremities (HP:0008968)2.52683622
35Bicuspid aortic valve (HP:0001647)2.51762052
36IgM deficiency (HP:0002850)2.50487958
37Panhypogammaglobulinemia (HP:0003139)2.50448535
38Gait imbalance (HP:0002141)2.48734045
39Nephronophthisis (HP:0000090)2.46665745
40Hematochezia (HP:0002573)2.45910369
41Drooling (HP:0002307)2.43507276
42Calf muscle hypertrophy (HP:0008981)2.40895944
43Tubulointerstitial nephritis (HP:0001970)2.40779594
44Acute myeloid leukemia (HP:0004808)2.40049443
45Epileptic encephalopathy (HP:0200134)2.39807272
46Astrocytoma (HP:0009592)2.39053466
47Abnormality of the astrocytes (HP:0100707)2.39053466
48Cerebral aneurysm (HP:0004944)2.37587741
49Abnormality of midbrain morphology (HP:0002418)2.34688901
50Molar tooth sign on MRI (HP:0002419)2.34688901
51Ventricular tachycardia (HP:0004756)2.28470936
52Chronic hepatic failure (HP:0100626)2.28443102
53Atonic seizures (HP:0010819)2.26933095
54Long clavicles (HP:0000890)2.23974527
55Proximal placement of thumb (HP:0009623)2.23412309
56Colitis (HP:0002583)2.22896063
57Agammaglobulinemia (HP:0004432)2.22744898
58Agnosia (HP:0010524)2.22523855
59Excessive salivation (HP:0003781)2.20154881
60Congenital primary aphakia (HP:0007707)2.19612684
61Cellulitis (HP:0100658)2.18900418
62Neoplasm of the adrenal cortex (HP:0100641)2.18327473
63Dialeptic seizures (HP:0011146)2.18215257
64Renal duplication (HP:0000075)2.17744298
65Abnormality of the renal medulla (HP:0100957)2.17279594
66Supernumerary ribs (HP:0005815)2.16469310
67Obsessive-compulsive behavior (HP:0000722)2.14953567
68Cutis marmorata (HP:0000965)2.14616068
69Lymphangioma (HP:0100764)2.14359889
70Depressed nasal tip (HP:0000437)2.14306257
71Stomach cancer (HP:0012126)2.14298989
72Atrial fibrillation (HP:0005110)2.14102805
73Elfin facies (HP:0004428)2.13781675
74Deviation of the thumb (HP:0009603)2.12835197
75Myotonia (HP:0002486)2.12423137
76Congenital stationary night blindness (HP:0007642)2.12299649
77Lipoatrophy (HP:0100578)2.11041675
78Broad palm (HP:0001169)2.09996522
79Exercise-induced myalgia (HP:0003738)2.08841398
80Papilloma (HP:0012740)2.07127540
81Verrucae (HP:0200043)2.07127540
82Abnormal drinking behavior (HP:0030082)2.06916854
83Polydipsia (HP:0001959)2.06916854
84Recurrent viral infections (HP:0004429)2.04238336
85Truncal obesity (HP:0001956)2.03169050
86Prominent nose (HP:0000448)2.03044061
87Neoplasm of the small intestine (HP:0100833)2.02152438
88Genital tract atresia (HP:0001827)2.02013325
89Protruding tongue (HP:0010808)2.01332933
90Abolished electroretinogram (ERG) (HP:0000550)2.00122263
91Nephrogenic diabetes insipidus (HP:0009806)1.99824707
92Absent speech (HP:0001344)1.99580641
93Primary atrial arrhythmia (HP:0001692)1.99296874
94Spontaneous hematomas (HP:0007420)1.99208746
95Reticulocytopenia (HP:0001896)1.99204750
96Supernumerary bones of the axial skeleton (HP:0009144)1.98888739
97Polyphagia (HP:0002591)1.98836033
98Increased circulating renin level (HP:0000848)1.98476062
99Genetic anticipation (HP:0003743)1.98283173
100Urethral obstruction (HP:0000796)1.97813079
101Aortic aneurysm (HP:0004942)1.97796673
102Distal arthrogryposis (HP:0005684)1.97584788
103Basal cell carcinoma (HP:0002671)1.95381957
104Macroorchidism (HP:0000053)1.94875114
105Limb dystonia (HP:0002451)1.94795526
106Renovascular hypertension (HP:0100817)1.94735085
107Fatigue (HP:0012378)1.94646670
108Supraventricular tachycardia (HP:0004755)1.94052107
109Low anterior hairline (HP:0000294)1.92790015
110Congenital hepatic fibrosis (HP:0002612)1.92598057
111Inability to walk (HP:0002540)1.91787059
112Neoplasm of the rectum (HP:0100743)1.91516088
113Failure to thrive in infancy (HP:0001531)1.91381839
114Supraventricular arrhythmia (HP:0005115)1.91326644
115Vaginal atresia (HP:0000148)1.90620301
116Thyroiditis (HP:0100646)1.90007191
117Myelodysplasia (HP:0002863)1.89683693
118Skull defect (HP:0001362)1.88803278
119Neoplasm of striated muscle (HP:0009728)1.88646886
120Thyroid-stimulating hormone excess (HP:0002925)1.87594287
121Syringomyelia (HP:0003396)1.86758715
122Spinal cord lesions (HP:0100561)1.86758715
123Glioma (HP:0009733)1.86734271
124Chorioretinal atrophy (HP:0000533)1.86252879
125Abnormal number of incisors (HP:0011064)1.86221133
126Hemiparesis (HP:0001269)1.86208181
127Abnormality of the pubic bones (HP:0003172)1.86193295
128Thick eyebrow (HP:0000574)1.85164584
129Deep philtrum (HP:0002002)1.85120853
130Supernumerary spleens (HP:0009799)1.84954660
131Abnormality of the metopic suture (HP:0005556)1.84586768
132Myoglobinuria (HP:0002913)1.84561726
133Centrally nucleated skeletal muscle fibers (HP:0003687)1.83709593
134Rhabdomyolysis (HP:0003201)1.83455288
135Absence seizures (HP:0002121)1.83311172
136Viral hepatitis (HP:0006562)1.82472693
137Enlarged penis (HP:0000040)1.82027379
138Abnormality of lateral ventricle (HP:0030047)1.81813717
139Benign neoplasm of the central nervous system (HP:0100835)1.81620284
140Neonatal respiratory distress (HP:0002643)1.81477867
141Hypsarrhythmia (HP:0002521)1.79489371
142Chest pain (HP:0100749)1.79125472
143High pitched voice (HP:0001620)1.78195731
144Intestinal polyp (HP:0005266)1.77988073
145Type 2 muscle fiber atrophy (HP:0003554)1.76873585
146Biliary tract neoplasm (HP:0100574)1.76713366
147Specific learning disability (HP:0001328)1.76695590
148Fibrous tissue neoplasm (HP:0012316)1.76437118
149Optic nerve hypoplasia (HP:0000609)1.75454913
150Poor coordination (HP:0002370)1.74920326
151Skin tags (HP:0010609)1.74747066
152Increased density of long bones (HP:0006392)1.74672223
153Epileptiform EEG discharges (HP:0011182)1.74268860
154Hyporeflexia of lower limbs (HP:0002600)1.74029495
155Malignant gastrointestinal tract tumors (HP:0006749)1.73716867
156Gastrointestinal carcinoma (HP:0002672)1.73716867
157Renal cortical cysts (HP:0000803)1.73561324
158Cystic liver disease (HP:0006706)1.73137029
159Broad foot (HP:0001769)1.72553130
160EEG with generalized epileptiform discharges (HP:0011198)1.72449604
161Hypomagnesemia (HP:0002917)1.71937402
162Abnormality of the renal cortex (HP:0011035)1.71236974
163Selective tooth agenesis (HP:0001592)1.70668686
164Abnormality of the corticospinal tract (HP:0002492)1.70593135
165Angiofibromas (HP:0010615)1.70246672
166Adenoma sebaceum (HP:0009720)1.70246672
167Hypoplastic iliac wings (HP:0002866)1.69720140
168Degeneration of the lateral corticospinal tracts (HP:0002314)1.69711470
169Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69711470
170Abnormality of the calf musculature (HP:0001430)1.69460266
171Abnormality of the diencephalon (HP:0010662)1.69311559
172Postaxial foot polydactyly (HP:0001830)1.69161458
173Gastrointestinal inflammation (HP:0004386)1.68052276
174Rhabdomyosarcoma (HP:0002859)1.67990556
175Postaxial hand polydactyly (HP:0001162)1.67846990
176Intestinal polyposis (HP:0200008)1.67326306
177Rimmed vacuoles (HP:0003805)1.67012077
178Poor eye contact (HP:0000817)1.66607463
179Fibroma (HP:0010614)1.66271846
180Ketoacidosis (HP:0001993)1.65576426
181Progressive inability to walk (HP:0002505)1.64226781
182Hyperinsulinemic hypoglycemia (HP:0000825)1.63658041
183Fair hair (HP:0002286)1.63419368
184Retinal dysplasia (HP:0007973)1.62072239
185Difficulty running (HP:0009046)1.61480659
186Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61295380
187Attenuation of retinal blood vessels (HP:0007843)1.61019370
188Oligodactyly (hands) (HP:0001180)1.60769983
189Aplasia/Hypoplasia of the tongue (HP:0010295)1.60730035
190Papillary thyroid carcinoma (HP:0002895)1.60346333
191Aplasia/Hypoplasia of the uvula (HP:0010293)1.60307144
192Narrow forehead (HP:0000341)1.60280434
193Generalized tonic-clonic seizures (HP:0002069)1.59656372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K4.38580025
2PKN24.00635092
3FRK3.74314434
4MAP3K103.53286183
5CDC73.23383827
6MARK12.90975095
7BMPR1B2.79785732
8FLT32.76966130
9EPHA42.61917800
10TTN2.39464500
11TGFBR22.36084655
12NEK22.31767663
13TGFBR12.23179346
14CASK2.20994902
15CDK122.19921584
16MAP3K42.15415979
17MAP4K12.12991619
18MAPK132.10110136
19MAP4K22.06748387
20TRIB32.04065077
21WNK31.93288863
22RPS6KB21.88330539
23NTRK21.80698953
24ACVR1B1.72985247
25TNIK1.69858329
26PHKG21.66287665
27PHKG11.66287665
28WEE11.66278416
29SCYL21.65686388
30CDK191.65391304
31BRD41.63768134
32CSF1R1.61990049
33STK101.57392871
34TSSK61.53428466
35NUAK11.47232927
36NTRK31.45309809
37PLK21.44021417
38CDK41.39316429
39MKNK11.38981208
40CCNB11.38914589
41STK41.38847158
42ERBB31.37515673
43MAP2K71.36816904
44TIE11.36715588
45BRSK21.36064012
46DYRK21.35462521
47ATR1.35241520
48INSRR1.31485423
49UHMK11.30015677
50SGK21.25355406
51PTK61.25120646
52DAPK21.22995342
53BTK1.22702552
54LRRK21.22014245
55PINK11.21897588
56GRK11.21396843
57PASK1.20349170
58NEK11.20023117
59TAOK31.15883423
60DYRK1A1.12973360
61CSNK1G21.12672619
62DYRK1B1.11908361
63MAP2K31.11117341
64TRIM281.10794653
65DMPK1.10678773
66PKN11.10152982
67SGK2231.09792212
68SGK4941.09792212
69ADRBK21.07754855
70BCKDK1.03988708
71TTK1.02040123
72JAK31.00708090
73CAMK1D0.98970995
74MAPKAPK30.98747157
75CDK60.98320075
76KIT0.98184421
77CSNK1A1L0.97667431
78CAMK10.97544172
79OBSCN0.97195031
80PAK30.97184129
81MAP3K80.96533544
82MTOR0.95932341
83MAP2K40.94927531
84CDK70.94345135
85PAK40.93782827
86SRPK10.93139867
87BCR0.93028903
88CSNK1G10.91977806
89AKT30.90766440
90OXSR10.90299233
91EPHA30.90091657
92VRK10.88216699
93DYRK30.87597980
94CLK10.85895085
95CSNK1G30.84246609
96PAK20.83743645
97ICK0.81615136
98CAMK40.81471348
99AURKB0.80670456
100CHEK10.80654748
101KDR0.80213119
102STK110.78206971
103NLK0.77086381
104ZAP700.76355328
105PNCK0.73917716
106CAMK1G0.72094150
107ATM0.71710369
108MELK0.68280372
109FGFR30.67248965
110RIPK10.66635343
111PIK3CG0.66620802
112STK30.66293981
113PRKCG0.66114887
114CDK20.64721087
115LATS10.62758327
116CAMKK20.62417709
117CDK90.62194181
118CDK30.61308840
119CDK50.60874593
120PDGFRA0.60631460
121MAPK110.60625822
122CAMK2A0.60223538
123WNK40.58903366
124PAK60.58473332
125PRKG10.58048219
126GRK60.57639183
127PRKCE0.57297022
128AKT20.57184819
129MUSK0.57092598
130PLK10.57005230
131MAPK120.56348451
132PRKAA10.55450260
133MAP3K70.55433017
134SGK10.55145949
135ILK0.55075555
136TEC0.55059502
137TYK20.54586642
138PTK2B0.54118617
139CHEK20.54009504
140RPS6KA40.52396613
141CSNK1D0.52223515
142MKNK20.52188715
143MARK20.52177974
144BUB10.50468959
145FES0.50457862
146MINK10.50217346
147ITK0.50108387
148MAPKAPK50.49653634
149PLK30.49522297
150ALK0.48992225
151SYK0.48410807
152PIM10.48343427
153HCK0.48335314
154FGFR20.48254577
155ERN10.47899473
156SIK10.47350167
157PDGFRB0.47277562
158LCK0.47261730
159FGFR10.47024154
160PIK3CA0.46106498
161NEK90.44796702
162PRKACA0.44574281
163STK390.43965206
164SGK30.42659631
165MARK30.42644793
166SIK20.42496117
167RPS6KC10.42162546
168RPS6KL10.42162546
169STK38L0.40441901
170CDK10.40071615
171PRKACB0.38526336
172MAPK70.38006563
173PRKDC0.37486869
174AKT10.35034910
175ZAK0.34739107

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.58913634
2Nicotine addiction_Homo sapiens_hsa050333.31925823
3Mismatch repair_Homo sapiens_hsa034303.15709305
4Circadian entrainment_Homo sapiens_hsa047132.29403713
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28289965
6Base excision repair_Homo sapiens_hsa034102.27216945
7Cell cycle_Homo sapiens_hsa041102.27105224
8Spliceosome_Homo sapiens_hsa030402.20971951
9Phototransduction_Homo sapiens_hsa047442.19715150
10GABAergic synapse_Homo sapiens_hsa047272.16413681
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.10658539
12RNA transport_Homo sapiens_hsa030132.02415687
13Morphine addiction_Homo sapiens_hsa050322.01707825
14Non-homologous end-joining_Homo sapiens_hsa034502.01094743
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.01008664
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.99475576
17Butanoate metabolism_Homo sapiens_hsa006501.92438306
18Glutamatergic synapse_Homo sapiens_hsa047241.91187941
19Regulation of autophagy_Homo sapiens_hsa041401.87826825
20B cell receptor signaling pathway_Homo sapiens_hsa046621.84219754
21Cardiac muscle contraction_Homo sapiens_hsa042601.74568823
22Taste transduction_Homo sapiens_hsa047421.71287824
23Lysine degradation_Homo sapiens_hsa003101.71120944
24Circadian rhythm_Homo sapiens_hsa047101.69663638
25Viral myocarditis_Homo sapiens_hsa054161.69150481
26Systemic lupus erythematosus_Homo sapiens_hsa053221.68433381
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.68228682
28Insulin secretion_Homo sapiens_hsa049111.67903973
29mRNA surveillance pathway_Homo sapiens_hsa030151.66135625
30Amphetamine addiction_Homo sapiens_hsa050311.62487082
31One carbon pool by folate_Homo sapiens_hsa006701.58311362
32Chronic myeloid leukemia_Homo sapiens_hsa052201.57330628
33Homologous recombination_Homo sapiens_hsa034401.56902337
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.54271302
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52824826
36Nucleotide excision repair_Homo sapiens_hsa034201.50769462
37Propanoate metabolism_Homo sapiens_hsa006401.50103831
38Dopaminergic synapse_Homo sapiens_hsa047281.49159615
39Primary immunodeficiency_Homo sapiens_hsa053401.47932987
40Oxytocin signaling pathway_Homo sapiens_hsa049211.47594042
41RNA degradation_Homo sapiens_hsa030181.45421407
42Calcium signaling pathway_Homo sapiens_hsa040201.43953721
43Long-term depression_Homo sapiens_hsa047301.41664268
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40217600
45Serotonergic synapse_Homo sapiens_hsa047261.39990637
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39355637
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.35582514
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35390224
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32705298
50Cholinergic synapse_Homo sapiens_hsa047251.32684276
51Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.29419247
52MicroRNAs in cancer_Homo sapiens_hsa052061.28701851
53Renin secretion_Homo sapiens_hsa049241.27174517
54Colorectal cancer_Homo sapiens_hsa052101.24517549
55Small cell lung cancer_Homo sapiens_hsa052221.23854213
56HTLV-I infection_Homo sapiens_hsa051661.21458094
57Viral carcinogenesis_Homo sapiens_hsa052031.20997333
58Nitrogen metabolism_Homo sapiens_hsa009101.20891148
59Salivary secretion_Homo sapiens_hsa049701.20603357
60cAMP signaling pathway_Homo sapiens_hsa040241.19670428
61Notch signaling pathway_Homo sapiens_hsa043301.19251351
62Antigen processing and presentation_Homo sapiens_hsa046121.18768054
63Dilated cardiomyopathy_Homo sapiens_hsa054141.18427193
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16306830
65Ribosome_Homo sapiens_hsa030101.16207656
66Herpes simplex infection_Homo sapiens_hsa051681.15356270
67Gastric acid secretion_Homo sapiens_hsa049711.13970794
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12522637
69Platelet activation_Homo sapiens_hsa046111.11622138
70Olfactory transduction_Homo sapiens_hsa047401.10998998
71Acute myeloid leukemia_Homo sapiens_hsa052211.10760481
72Dorso-ventral axis formation_Homo sapiens_hsa043201.09404702
73mTOR signaling pathway_Homo sapiens_hsa041501.09322387
74Peroxisome_Homo sapiens_hsa041461.09246619
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08975508
76Cocaine addiction_Homo sapiens_hsa050301.08608300
77Adherens junction_Homo sapiens_hsa045201.07984670
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.07838820
79Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07179225
80Ether lipid metabolism_Homo sapiens_hsa005651.06629933
81Non-small cell lung cancer_Homo sapiens_hsa052231.06034051
82Fanconi anemia pathway_Homo sapiens_hsa034601.04062414
83Pancreatic cancer_Homo sapiens_hsa052121.03964077
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.00952295
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.99362092
86Long-term potentiation_Homo sapiens_hsa047200.99106175
87Osteoclast differentiation_Homo sapiens_hsa043800.98133650
88Insulin resistance_Homo sapiens_hsa049310.97416075
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.95805385
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.95180136
91Hepatitis B_Homo sapiens_hsa051610.92459019
92Axon guidance_Homo sapiens_hsa043600.92300014
93Measles_Homo sapiens_hsa051620.92162959
94Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90532042
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89886309
96Epstein-Barr virus infection_Homo sapiens_hsa051690.89767231
97Hedgehog signaling pathway_Homo sapiens_hsa043400.89270973
98p53 signaling pathway_Homo sapiens_hsa041150.87194823
99Parkinsons disease_Homo sapiens_hsa050120.86941135
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.85020159
101Type II diabetes mellitus_Homo sapiens_hsa049300.84976169
102Thyroid cancer_Homo sapiens_hsa052160.84575609
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84316239
104Proteoglycans in cancer_Homo sapiens_hsa052050.83519085
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83359798
106HIF-1 signaling pathway_Homo sapiens_hsa040660.83105715
107Focal adhesion_Homo sapiens_hsa045100.82437543
108Leukocyte transendothelial migration_Homo sapiens_hsa046700.81379412
109Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81003449
110Linoleic acid metabolism_Homo sapiens_hsa005910.80613026
111AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79812579
112Gap junction_Homo sapiens_hsa045400.78509684
113Glucagon signaling pathway_Homo sapiens_hsa049220.78179863
114Synaptic vesicle cycle_Homo sapiens_hsa047210.76640997
115beta-Alanine metabolism_Homo sapiens_hsa004100.76389748
116N-Glycan biosynthesis_Homo sapiens_hsa005100.75403505
117Insulin signaling pathway_Homo sapiens_hsa049100.74509769
118Ovarian steroidogenesis_Homo sapiens_hsa049130.72282734
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71701213
120Maturity onset diabetes of the young_Homo sapiens_hsa049500.70808008
121Pyrimidine metabolism_Homo sapiens_hsa002400.69723657
122Pathways in cancer_Homo sapiens_hsa052000.69556866
123T cell receptor signaling pathway_Homo sapiens_hsa046600.69447709
124Oocyte meiosis_Homo sapiens_hsa041140.69175149
125TGF-beta signaling pathway_Homo sapiens_hsa043500.68887564
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.68584389
127Leishmaniasis_Homo sapiens_hsa051400.68171568
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67670793
129AMPK signaling pathway_Homo sapiens_hsa041520.67459114
130Biosynthesis of amino acids_Homo sapiens_hsa012300.67368131
131Toxoplasmosis_Homo sapiens_hsa051450.66924445
132Alcoholism_Homo sapiens_hsa050340.66795806
133Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64945271
134Endometrial cancer_Homo sapiens_hsa052130.64843066
135Glycerolipid metabolism_Homo sapiens_hsa005610.64649219
136Glioma_Homo sapiens_hsa052140.64635189
137Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64365933
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.64069825
139VEGF signaling pathway_Homo sapiens_hsa043700.62757417
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.62239286
141Carbon metabolism_Homo sapiens_hsa012000.62129773
142Ras signaling pathway_Homo sapiens_hsa040140.61927649
143FoxO signaling pathway_Homo sapiens_hsa040680.61669034
144Basal transcription factors_Homo sapiens_hsa030220.61038555
145Hematopoietic cell lineage_Homo sapiens_hsa046400.59806007
146Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58413922
147Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.58128138
148RNA polymerase_Homo sapiens_hsa030200.57831815
149NF-kappa B signaling pathway_Homo sapiens_hsa040640.57585699
150Tryptophan metabolism_Homo sapiens_hsa003800.57582449
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.57015844
152Oxidative phosphorylation_Homo sapiens_hsa001900.56725800
153Legionellosis_Homo sapiens_hsa051340.55999856
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55922453
155Alzheimers disease_Homo sapiens_hsa050100.55910614
156Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55560355
157Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55547092
158Pancreatic secretion_Homo sapiens_hsa049720.55141371
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.53848000
160Influenza A_Homo sapiens_hsa051640.53304784
161Fatty acid degradation_Homo sapiens_hsa000710.53115019
162Melanogenesis_Homo sapiens_hsa049160.52169022
163Purine metabolism_Homo sapiens_hsa002300.51513492
164ABC transporters_Homo sapiens_hsa020100.51144123
165Hippo signaling pathway_Homo sapiens_hsa043900.50370343
166Prostate cancer_Homo sapiens_hsa052150.48684438
167Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47438662
168Basal cell carcinoma_Homo sapiens_hsa052170.46855909
169Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46560992
170Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46030393
171Phospholipase D signaling pathway_Homo sapiens_hsa040720.45081020
172MAPK signaling pathway_Homo sapiens_hsa040100.44694826
173Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44224112
174Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43629366
175Wnt signaling pathway_Homo sapiens_hsa043100.42951061
176Rap1 signaling pathway_Homo sapiens_hsa040150.42770472

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