CEP120

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that functions in the microtubule-dependent coupling of the nucleus and the centrosome. A similar protein in mouse plays a role in both interkinetic nuclear migration, which is a characteristic pattern of nuclear movement in neural progenitors, and in neural progenitor self-renewal. Mutations in this gene are predicted to result in neurogenic defects. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.82139563
2nuclear pore organization (GO:0006999)4.91190841
3positive regulation of gamma-delta T cell activation (GO:0046645)4.45475764
4pre-miRNA processing (GO:0031054)4.26920665
5pore complex assembly (GO:0046931)4.15872367
6negative T cell selection (GO:0043383)4.15096494
7negative thymic T cell selection (GO:0045060)4.12795507
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.03487724
9histone H3-K36 demethylation (GO:0070544)3.99367862
10phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.89011646
11synaptic vesicle maturation (GO:0016188)3.88303166
12regulation of gamma-delta T cell differentiation (GO:0045586)3.88138293
13embryonic process involved in female pregnancy (GO:0060136)3.85674127
14positive T cell selection (GO:0043368)3.76462428
15regulation of B cell receptor signaling pathway (GO:0050855)3.53045606
16regulation of histone H3-K27 methylation (GO:0061085)3.48732720
17regulation of gamma-delta T cell activation (GO:0046643)3.47051131
18cerebellar Purkinje cell differentiation (GO:0021702)3.45679599
19B cell receptor signaling pathway (GO:0050853)3.44783780
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.40437819
21cell migration in hindbrain (GO:0021535)3.30670953
22positive thymic T cell selection (GO:0045059)3.30033979
23regulation of synaptic vesicle exocytosis (GO:2000300)3.30030655
24T cell selection (GO:0045058)3.29010453
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27152159
26negative regulation of histone methylation (GO:0031061)3.24976864
27positive regulation of granulocyte differentiation (GO:0030854)3.23155415
28sodium ion export (GO:0071436)3.22264086
29histone H3-K4 trimethylation (GO:0080182)3.19808206
30thymic T cell selection (GO:0045061)3.16609663
31negative regulation of inclusion body assembly (GO:0090084)3.16542470
32regulation of NFAT protein import into nucleus (GO:0051532)3.15782907
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.15701869
34cilium or flagellum-dependent cell motility (GO:0001539)3.13612774
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.13324337
36response to interleukin-15 (GO:0070672)3.11122123
37regulation of fibroblast apoptotic process (GO:2000269)3.10304779
38tolerance induction (GO:0002507)3.05544604
39dosage compensation (GO:0007549)3.02608131
40synaptic vesicle exocytosis (GO:0016079)2.98673976
41hepatocyte apoptotic process (GO:0097284)2.97112134
42histone lysine demethylation (GO:0070076)2.96809872
43response to pheromone (GO:0019236)2.96560470
44mitotic sister chromatid cohesion (GO:0007064)2.96284608
45acrosome reaction (GO:0007340)2.96235667
46glucocorticoid receptor signaling pathway (GO:0042921)2.94267522
47negative regulation of DNA repair (GO:0045738)2.92882099
48layer formation in cerebral cortex (GO:0021819)2.92046509
49interleukin-6-mediated signaling pathway (GO:0070102)2.91113106
50positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90516555
51regulation of synaptic vesicle transport (GO:1902803)2.90283430
52regulation of B cell differentiation (GO:0045577)2.89678192
53regulation of RNA export from nucleus (GO:0046831)2.89615219
54antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.87906764
55monoubiquitinated protein deubiquitination (GO:0035520)2.87817378
56regulation of ARF protein signal transduction (GO:0032012)2.87374421
57peptidyl-lysine dimethylation (GO:0018027)2.87232679
58regulation of clathrin-mediated endocytosis (GO:2000369)2.86262142
59labyrinthine layer development (GO:0060711)2.82695684
60peptidyl-lysine trimethylation (GO:0018023)2.82358395
61piRNA metabolic process (GO:0034587)2.76765375
62acrosome assembly (GO:0001675)2.76428342
63histone H3-K9 demethylation (GO:0033169)2.76249181
64cytoplasmic mRNA processing body assembly (GO:0033962)2.76109196
65histone demethylation (GO:0016577)2.75485041
66regulation of nucleobase-containing compound transport (GO:0032239)2.74714878
67brain morphogenesis (GO:0048854)2.73833108
68glutamate secretion (GO:0014047)2.71261350
69microtubule severing (GO:0051013)2.71112539
70establishment of nucleus localization (GO:0040023)2.70547502
71histone H4-K16 acetylation (GO:0043984)2.69994606
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.69850101
73response to laminar fluid shear stress (GO:0034616)2.69476039
74definitive hemopoiesis (GO:0060216)2.67805246
75negative regulation of organelle assembly (GO:1902116)2.65237887
76negative regulation of erythrocyte differentiation (GO:0045647)2.61303698
77regulation of histone methylation (GO:0031060)2.60864683
78antigen processing and presentation of endogenous antigen (GO:0019883)2.60779667
79locomotory exploration behavior (GO:0035641)2.59848529
80negative regulation of microtubule polymerization (GO:0031115)2.58570789
81negative regulation of fibroblast apoptotic process (GO:2000270)2.58506041
82neurotransmitter secretion (GO:0007269)2.58398543
83peptidyl-threonine phosphorylation (GO:0018107)2.57813353
84histone H3-K9 modification (GO:0061647)2.57256468
85vesicle transport along microtubule (GO:0047496)2.54581067
86membrane depolarization during action potential (GO:0086010)2.53671538
87sperm motility (GO:0030317)2.53112164
88peptidyl-arginine N-methylation (GO:0035246)2.52323585
89peptidyl-arginine methylation (GO:0018216)2.52323585
90oocyte development (GO:0048599)2.51730095
91positive regulation of B cell differentiation (GO:0045579)2.51241202
92regulation of chromatin binding (GO:0035561)2.50722797
93negative regulation of T cell mediated immunity (GO:0002710)2.50109506
94nerve growth factor signaling pathway (GO:0038180)2.50010836
95axon cargo transport (GO:0008088)2.49978951
96histone H3-K4 methylation (GO:0051568)2.49823605
97corticosteroid receptor signaling pathway (GO:0031958)2.49703862
98protein K48-linked deubiquitination (GO:0071108)2.49214581
99positive regulation of alpha-beta T cell proliferation (GO:0046641)2.47864970
100leukocyte aggregation (GO:0070486)2.47680521
101protein polyglutamylation (GO:0018095)2.46394514
102synaptonemal complex organization (GO:0070193)2.45669673
103negative regulation of histone modification (GO:0031057)2.45356280
104positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.45257004
105T cell migration (GO:0072678)2.45221803
106regulation of granulocyte differentiation (GO:0030852)2.43842877
107stress granule assembly (GO:0034063)2.43054308
108organelle transport along microtubule (GO:0072384)2.42605113
109regulation of alpha-beta T cell proliferation (GO:0046640)2.42452270
110positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.41631835
111positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.41631835
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.41631835
113cellular extravasation (GO:0045123)2.41600529
114fusion of sperm to egg plasma membrane (GO:0007342)2.41295148
115cellular response to interleukin-15 (GO:0071350)2.40016511
116mitotic chromosome condensation (GO:0007076)2.39334311
117mature B cell differentiation (GO:0002335)2.39025449
118hypotonic response (GO:0006971)2.38940727
119negative regulation of cell killing (GO:0031342)2.38570339
120negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38570339
121synaptonemal complex assembly (GO:0007130)2.38175723
122calcium ion-dependent exocytosis (GO:0017156)2.36884182
123regulation of meiosis I (GO:0060631)2.36620636
124antigen receptor-mediated signaling pathway (GO:0050851)2.36478122
125alpha-beta T cell differentiation (GO:0046632)2.35869859
126intracellular estrogen receptor signaling pathway (GO:0030520)2.34784654
127protein targeting to Golgi (GO:0000042)2.34205289
128peptidyl-threonine modification (GO:0018210)2.33522152
129synaptic vesicle docking involved in exocytosis (GO:0016081)2.33082215
130nucleus organization (GO:0006997)2.32891713
131establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.31827902
132mitochondrion transport along microtubule (GO:0047497)2.31827902
133activation of protein kinase A activity (GO:0034199)2.31701166
134neurofilament cytoskeleton organization (GO:0060052)2.31479666
135protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.31463925
136positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.31437909
137regulation of histone H3-K9 methylation (GO:0051570)2.31421379
138genitalia morphogenesis (GO:0035112)2.31217483
139dendrite morphogenesis (GO:0048813)2.30981197
140regulation of necroptotic process (GO:0060544)2.30667023
141negative regulation of lymphocyte mediated immunity (GO:0002707)2.30534572
142male meiosis (GO:0007140)2.30481990
143cellular response to ethanol (GO:0071361)2.30133727
144axonemal dynein complex assembly (GO:0070286)2.30061269
145synaptic vesicle endocytosis (GO:0048488)2.29847179
146regulation of transforming growth factor beta2 production (GO:0032909)2.29613024
147T cell receptor signaling pathway (GO:0050852)2.29099251
148mating behavior (GO:0007617)2.28758515
149peptidyl-threonine dephosphorylation (GO:0035970)2.28671757
150cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.28615264
151Golgi to endosome transport (GO:0006895)2.28512185
152cell communication by electrical coupling (GO:0010644)2.28377641
153multicellular organism reproduction (GO:0032504)2.28080185
154T cell homeostasis (GO:0043029)2.27711800
155NLS-bearing protein import into nucleus (GO:0006607)2.26773225
156establishment of mitochondrion localization (GO:0051654)2.26651480
157positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.26244835
158protein dealkylation (GO:0008214)2.26110580
159protein demethylation (GO:0006482)2.26110580
160positive regulation of tolerance induction (GO:0002645)2.26027365
161negative regulation of chromatin modification (GO:1903309)2.24505386
162histone H3-K9 methylation (GO:0051567)2.24107599
163neuromuscular synaptic transmission (GO:0007274)2.23750379
164clathrin coat assembly (GO:0048268)2.23684717
165establishment of protein localization to Golgi (GO:0072600)2.23674603
166negative regulation of NF-kappaB import into nucleus (GO:0042347)2.22458624
167regulation of synapse structural plasticity (GO:0051823)2.20206734
168nucleosome disassembly (GO:0006337)2.20009004
169protein-DNA complex disassembly (GO:0032986)2.20009004
170microtubule-based movement (GO:0007018)2.19947479
171sister chromatid cohesion (GO:0007062)2.19489317
172sperm-egg recognition (GO:0035036)2.19225077
173positive regulation by organism of defense response of other organism involved in symbiotic interact2.18393451
174modulation by symbiont of host immune response (GO:0052553)2.18393451
175modulation by symbiont of host defense response (GO:0052031)2.18393451
176modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.18393451
177regulation of cilium movement (GO:0003352)2.17148349
178cellular potassium ion homeostasis (GO:0030007)2.16880435
179neuromuscular process controlling balance (GO:0050885)2.16498453
180spermatid development (GO:0007286)2.16346547
181protein localization to chromosome (GO:0034502)2.15088373
182positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.14868708
183regulation of microtubule-based movement (GO:0060632)2.13620724
184cytoskeletal anchoring at plasma membrane (GO:0007016)2.12393379
185cell-cell recognition (GO:0009988)2.11513807

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.19776549
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.99782254
3IRF8_22096565_ChIP-ChIP_GC-B_Human2.79533868
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.67566127
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.61622462
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.46039327
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.44362639
8MYB_26560356_Chip-Seq_TH2_Human2.36019559
9STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32519914
10MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31770950
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28022090
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.26054293
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.25810220
14SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17735993
15MYB_26560356_Chip-Seq_TH1_Human2.05374459
16FOXM1_23109430_ChIP-Seq_U2OS_Human2.03640371
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03326101
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.02421566
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.02404969
20REST_21632747_ChIP-Seq_MESCs_Mouse2.00325579
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94602224
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92700677
23KDM2B_26808549_Chip-Seq_DND41_Human1.91375211
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90606861
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.85127562
26KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81280799
27MYC_22102868_ChIP-Seq_BL_Human1.78743070
28IRF8_27001747_Chip-Seq_BMDM_Mouse1.78406972
29EGR1_19374776_ChIP-ChIP_THP-1_Human1.77908998
30RBPJ_22232070_ChIP-Seq_NCS_Mouse1.76929979
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76592146
32* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.72737958
33DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.72480134
34KDM2B_26808549_Chip-Seq_K562_Human1.70008163
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.68403230
36DROSHA_22980978_ChIP-Seq_HELA_Human1.66596444
37* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.64079926
38REST_18959480_ChIP-ChIP_MESCs_Mouse1.62929393
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62582588
40GATA1_22025678_ChIP-Seq_K562_Human1.62132116
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.62025139
42RUNX_20019798_ChIP-Seq_JUKART_Human1.61052985
43ZNF274_21170338_ChIP-Seq_K562_Hela1.60554269
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58285364
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55975517
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55922111
47* FOXO3_23340844_ChIP-Seq_DLD1_Human1.54034824
48FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53855698
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.53327057
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50993844
51GATA3_27048872_Chip-Seq_THYMUS_Human1.50376028
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.50014186
53SCL_19346495_ChIP-Seq_HPC-7_Human1.49315921
54RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.46444162
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45152506
56WT1_19549856_ChIP-ChIP_CCG9911_Human1.43361364
57E2F4_17652178_ChIP-ChIP_JURKAT_Human1.41492215
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.41328216
59RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.39310640
60TCF7_22412390_ChIP-Seq_EML_Mouse1.39240774
61KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.39158392
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37135734
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.36468157
64MAF_26560356_Chip-Seq_TH1_Human1.35071207
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33357235
66SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32217055
67TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31766972
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31246574
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29482813
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29447350
71E2F7_22180533_ChIP-Seq_HELA_Human1.29142601
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.28140777
73PU_27001747_Chip-Seq_BMDM_Mouse1.26038427
74ELK4_26923725_Chip-Seq_MESODERM_Mouse1.25480018
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.24447121
76VDR_24787735_ChIP-Seq_THP-1_Human1.23734120
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23204556
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22907645
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22819872
80EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21913121
81STAT3_23295773_ChIP-Seq_U87_Human1.20327870
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.20100603
83PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19802095
84EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18758481
85* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.15514088
86SMAD3_21741376_ChIP-Seq_ESCs_Human1.14466909
87SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13527148
88TP53_16413492_ChIP-PET_HCT116_Human1.13063139
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.12809633
90SPI1_23547873_ChIP-Seq_NB4_Human1.09982861
91TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09976064
92SMAD_19615063_ChIP-ChIP_OVARY_Human1.09856188
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09013645
94AR_19668381_ChIP-Seq_PC3_Human1.08858653
95RUNX1_22412390_ChIP-Seq_EML_Mouse1.06215193
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05315570
97FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04598314
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.04438056
99SPI1_23127762_ChIP-Seq_K562_Human1.04117408
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04108202
101NOTCH1_21737748_ChIP-Seq_TLL_Human1.03937722
102WDR5_24793694_ChIP-Seq_LNCAP_Human1.03884817
103WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03218497
104WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02465144
105YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01548065
106CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01469471
107STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01210327
108FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.01111429
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.00380171
110BRD4_25478319_ChIP-Seq_HGPS_Human1.00234514
111TET1_21490601_ChIP-Seq_MESCs_Mouse1.00224616
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00092774
113TCF4_23295773_ChIP-Seq_U87_Human1.00077706
114* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00015605
115SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98055099
116SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98055099
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98038159
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97974148
119* SMAD4_21799915_ChIP-Seq_A2780_Human0.96312211
120RNF2_27304074_Chip-Seq_ESCs_Mouse0.96257781
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95899334
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94894200
123SOX2_21211035_ChIP-Seq_LN229_Gbm0.94760199
124PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.94413945
125CIITA_25753668_ChIP-Seq_RAJI_Human0.94320453
126* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.93089670
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92971837
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92649719
129KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92649719
130KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92649719
131NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.92171539
132POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.91969564
133GATA2_19941826_ChIP-Seq_K562_Human0.91960978
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91685526
135TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91461164
136E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91243934
137TBL1_22424771_ChIP-Seq_293T_Human0.90986623
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90283657
139GATA3_26560356_Chip-Seq_TH2_Human0.90148014
140RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.90121428
141UTX_26944678_Chip-Seq_JUKART_Human0.89943327
142FLI1_27457419_Chip-Seq_LIVER_Mouse0.89930647
143TCF4_18268006_ChIP-ChIP_LS174T_Human0.89838066
144TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89807345
145TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89144174
146NR3C1_23031785_ChIP-Seq_PC12_Mouse0.89083620
147TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88889355
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.88169398
149CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88143599
150STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88055943
151SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.87105117
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85817650
153VDR_24763502_ChIP-Seq_THP-1_Human0.85314198
154CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84886293
155GATA1_19941826_ChIP-Seq_K562_Human0.84731398
156KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84641704
157EZH2_27294783_Chip-Seq_NPCs_Mouse0.84510859
158PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83846826
159ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83786004
160AHR_22903824_ChIP-Seq_MCF-7_Human0.83642813
161MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.83121874
162GBX2_23144817_ChIP-Seq_PC3_Human0.82980916
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.82778146
164* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.82476166
165PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82214427
166EZH2_27294783_Chip-Seq_ESCs_Mouse0.81798429
167P53_22127205_ChIP-Seq_FIBROBLAST_Human0.81715147
168SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.81705659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.95937413
2MP0002009_preneoplasia3.78697418
3MP0000569_abnormal_digit_pigmentation3.31748358
4MP0005410_abnormal_fertilization2.98798258
5MP0004270_analgesia2.98504693
6MP0008877_abnormal_DNA_methylation2.89797905
7MP0003787_abnormal_imprinting2.75480874
8MP0003300_gastrointestinal_ulcer2.73379182
9MP0002396_abnormal_hematopoietic_system2.45978677
10MP0002166_altered_tumor_susceptibility2.45695899
11MP0003635_abnormal_synaptic_transmissio2.38467172
12MP0005423_abnormal_somatic_nervous2.28143134
13MP0002653_abnormal_ependyma_morphology2.08420222
14MP0001800_abnormal_humoral_immune2.05313501
15MP0002006_tumorigenesis1.90962170
16MP0006072_abnormal_retinal_apoptosis1.88366908
17MP0003121_genomic_imprinting1.87980781
18MP0001835_abnormal_antigen_presentation1.87604950
19MP0002734_abnormal_mechanical_nocicepti1.84693049
20MP0004808_abnormal_hematopoietic_stem1.84648824
21MP0004811_abnormal_neuron_physiology1.83114017
22MP0002398_abnormal_bone_marrow1.81531015
23MP0009046_muscle_twitch1.80928787
24MP0004858_abnormal_nervous_system1.79677620
25MP0002184_abnormal_innervation1.78828197
26MP0003828_pulmonary_edema1.77367400
27MP0005409_darkened_coat_color1.75690518
28MP0008260_abnormal_autophagy1.73012108
29MP0004885_abnormal_endolymph1.68082548
30MP0003656_abnormal_erythrocyte_physiolo1.68076850
31MP0003303_peritoneal_inflammation1.67102555
32MP0002063_abnormal_learning/memory/cond1.67099947
33MP0000778_abnormal_nervous_system1.65777074
34MP0003705_abnormal_hypodermis_morpholog1.65124483
35MP0005551_abnormal_eye_electrophysiolog1.63627517
36MP0000955_abnormal_spinal_cord1.62660101
37MP0001851_eye_inflammation1.59460349
38MP0008569_lethality_at_weaning1.57913086
39MP0002420_abnormal_adaptive_immunity1.56746483
40MP0003698_abnormal_male_reproductive1.55574885
41MP0005310_abnormal_salivary_gland1.55229842
42MP0002064_seizures1.54101588
43MP0002735_abnormal_chemical_nociception1.53460357
44MP0002722_abnormal_immune_system1.53124577
45MP0003436_decreased_susceptibility_to1.52700248
46MP0001819_abnormal_immune_cell1.51401733
47MP0002272_abnormal_nervous_system1.50787992
48MP0000685_abnormal_immune_system1.47645592
49MP0001790_abnormal_immune_system1.47322824
50MP0005387_immune_system_phenotype1.47322824
51MP0000689_abnormal_spleen_morphology1.46568445
52MP0006276_abnormal_autonomic_nervous1.45769413
53MP0002723_abnormal_immune_serum1.45322922
54MP0002405_respiratory_system_inflammati1.45279417
55MP0009745_abnormal_behavioral_response1.43407563
56MP0005000_abnormal_immune_tolerance1.42908259
57MP0002882_abnormal_neuron_morphology1.42805660
58MP0000716_abnormal_immune_system1.42412884
59MP0002452_abnormal_antigen_presenting1.41381221
60MP0002877_abnormal_melanocyte_morpholog1.40528737
61MP0005253_abnormal_eye_physiology1.40118412
62MP0001929_abnormal_gametogenesis1.39973315
63MP0003122_maternal_imprinting1.38829661
64MP0004185_abnormal_adipocyte_glucose1.37618790
65MP0004233_abnormal_muscle_weight1.36520461
66MP0005623_abnormal_meninges_morphology1.35595158
67MP0001968_abnormal_touch/_nociception1.35286646
68MP0008961_abnormal_basal_metabolism1.34113991
69MP0002229_neurodegeneration1.33975171
70MP0005386_behavior/neurological_phenoty1.33238615
71MP0004924_abnormal_behavior1.33238615
72MP0003329_amyloid_beta_deposits1.32201765
73MP0004084_abnormal_cardiac_muscle1.31577883
74MP0002067_abnormal_sensory_capabilities1.30010969
75MP0003221_abnormal_cardiomyocyte_apopto1.29178297
76MP0002572_abnormal_emotion/affect_behav1.28342699
77MP0001486_abnormal_startle_reflex1.28005522
78MP0003763_abnormal_thymus_physiology1.27985571
79MP0009333_abnormal_splenocyte_physiolog1.26912470
80MP0003045_fibrosis1.26910691
81MP0004947_skin_inflammation1.26843851
82MP0002152_abnormal_brain_morphology1.26454293
83MP0001873_stomach_inflammation1.26001896
84MP0003724_increased_susceptibility_to1.25684294
85MP0004381_abnormal_hair_follicle1.24599333
86MP0005275_abnormal_skin_tensile1.23397144
87MP0003861_abnormal_nervous_system1.22248650
88MP0008057_abnormal_DNA_replication1.21609235
89MP0002733_abnormal_thermal_nociception1.20078637
90MP0003123_paternal_imprinting1.18840741
91MP0001970_abnormal_pain_threshold1.18786870
92MP0005394_taste/olfaction_phenotype1.17219130
93MP0005499_abnormal_olfactory_system1.17219130
94MP0010155_abnormal_intestine_physiology1.16328891
95MP0005076_abnormal_cell_differentiation1.15183215
96MP0002429_abnormal_blood_cell1.13147376
97MP0002909_abnormal_adrenal_gland1.11503616
98MP0005621_abnormal_cell_physiology1.10524017
99MP0003077_abnormal_cell_cycle1.09966138
100MP0002419_abnormal_innate_immunity1.07074839
101MP0002102_abnormal_ear_morphology1.05501038
102MP0000015_abnormal_ear_pigmentation1.05120358
103MP0002138_abnormal_hepatobiliary_system1.04592037
104MP0001984_abnormal_olfaction1.04470278
105MP0005645_abnormal_hypothalamus_physiol1.03949741
106MP0006054_spinal_hemorrhage1.03861114
107MP0003634_abnormal_glial_cell1.02871434
108MP0004134_abnormal_chest_morphology1.02607354
109MP0002086_abnormal_extraembryonic_tissu1.00914007
110MP0002638_abnormal_pupillary_reflex1.00812563
111MP0003984_embryonic_growth_retardation1.00547314
112MP0001849_ear_inflammation1.00230032
113MP0002088_abnormal_embryonic_growth/wei0.99825099
114MP0003633_abnormal_nervous_system0.98478360
115MP0004957_abnormal_blastocyst_morpholog0.97250717
116MP0002066_abnormal_motor_capabilities/c0.97042492
117MP0005380_embryogenesis_phenotype0.96911742
118MP0005187_abnormal_penis_morphology0.96580952
119MP0003943_abnormal_hepatobiliary_system0.95172401
120MP0001348_abnormal_lacrimal_gland0.95120690
121MP0002168_other_aberrant_phenotype0.94974326
122MP0002557_abnormal_social/conspecific_i0.94686305
123MP0002084_abnormal_developmental_patter0.94357627
124MP0004145_abnormal_muscle_electrophysio0.93978083
125MP0001661_extended_life_span0.93786909
126MP0001299_abnormal_eye_distance/0.93736717
127MP0001915_intracranial_hemorrhage0.93487985
128MP0002752_abnormal_somatic_nervous0.93456282
129MP0001730_embryonic_growth_arrest0.92924274
130MP0000465_gastrointestinal_hemorrhage0.92418324
131MP0002019_abnormal_tumor_incidence0.92334576
132MP0003631_nervous_system_phenotype0.92146156
133MP0001986_abnormal_taste_sensitivity0.91523421
134MP0002161_abnormal_fertility/fecundity0.91410306
135MP0008789_abnormal_olfactory_epithelium0.91385827
136MP0010094_abnormal_chromosome_stability0.90583892
137MP0005025_abnormal_response_to0.90167623
138MP0003632_abnormal_nervous_system0.89571176
139MP0010307_abnormal_tumor_latency0.89404058
140MP0008438_abnormal_cutaneous_collagen0.88773661
141MP0005671_abnormal_response_to0.88028440
142MP0002998_abnormal_bone_remodeling0.87941848
143MP0003111_abnormal_nucleus_morphology0.87357576
144MP0009703_decreased_birth_body0.86899423
145MP0003866_abnormal_defecation0.86518938
146MP0004510_myositis0.86349666
147MP0003566_abnormal_cell_adhesion0.85646398
148MP0010234_abnormal_vibrissa_follicle0.85440755
149MP0001502_abnormal_circadian_rhythm0.84714838
150MP0000858_altered_metastatic_potential0.84694028
151MP0001529_abnormal_vocalization0.83908042
152MP0003091_abnormal_cell_migration0.82513931
153MP0002210_abnormal_sex_determination0.82216486
154MP0000350_abnormal_cell_proliferation0.81695605
155MP0001440_abnormal_grooming_behavior0.81386446
156MP0009115_abnormal_fat_cell0.81366216
157MP0001879_abnormal_lymphatic_vessel0.81337183
158MP0001697_abnormal_embryo_size0.80658989
159MP0005464_abnormal_platelet_physiology0.80531916
160MP0000428_abnormal_craniofacial_morphol0.80241907
161MP0003950_abnormal_plasma_membrane0.80082530
162MP0010352_gastrointestinal_tract_polyps0.79053794
163MP0004264_abnormal_extraembryonic_tissu0.77970551
164MP0000703_abnormal_thymus_morphology0.77920892
165MP0002736_abnormal_nociception_after0.77761972
166MP0005384_cellular_phenotype0.77511594
167MP0003448_altered_tumor_morphology0.77134863
168MP0005503_abnormal_tendon_morphology0.76795337
169MP0008995_early_reproductive_senescence0.76643906
170MP0003453_abnormal_keratinocyte_physiol0.76173941
171MP0008770_decreased_survivor_rate0.75651938
172MP0003183_abnormal_peptide_metabolism0.74797442
173MP0002928_abnormal_bile_duct0.74037170
174MP0003890_abnormal_embryonic-extraembry0.73741241
175MP0003786_premature_aging0.73470254
176MP0000920_abnormal_myelination0.73376461
177MP0001845_abnormal_inflammatory_respons0.72803009
178MP0008775_abnormal_heart_ventricle0.72785050
179MP0001672_abnormal_embryogenesis/_devel0.72269445
180MP0005451_abnormal_body_composition0.72164716

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)3.98163618
2Abnormality of T cell number (HP:0011839)3.48789852
3Visual hallucinations (HP:0002367)3.34663503
4Subacute progressive viral hepatitis (HP:0006572)3.33156784
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.18731744
6Abnormality of the lower motor neuron (HP:0002366)3.09148189
7Bony spicule pigmentary retinopathy (HP:0007737)3.04993984
8Recurrent bronchitis (HP:0002837)3.04460466
9Genetic anticipation (HP:0003743)2.98672047
10Eczematoid dermatitis (HP:0000976)2.91775987
11Spontaneous hematomas (HP:0007420)2.89488767
12Supranuclear gaze palsy (HP:0000605)2.87134847
13Myokymia (HP:0002411)2.79108346
14Progressive cerebellar ataxia (HP:0002073)2.77455375
15Papillary thyroid carcinoma (HP:0002895)2.75549998
16Heterotopia (HP:0002282)2.72332821
17Amyotrophic lateral sclerosis (HP:0007354)2.68635560
18Action tremor (HP:0002345)2.65498845
19Abnormality of ocular smooth pursuit (HP:0000617)2.58046812
20Impaired smooth pursuit (HP:0007772)2.56660118
21Insidious onset (HP:0003587)2.56054956
22Termporal pattern (HP:0011008)2.56054956
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.55947745
24Congenital stationary night blindness (HP:0007642)2.54222790
25Urinary bladder sphincter dysfunction (HP:0002839)2.51458152
26Autoimmune hemolytic anemia (HP:0001890)2.50116873
27Insomnia (HP:0100785)2.47963749
28Truncal ataxia (HP:0002078)2.47349871
29Dysmetric saccades (HP:0000641)2.46389586
30Volvulus (HP:0002580)2.44231609
31IgA deficiency (HP:0002720)2.44139477
32Abnormality of the corticospinal tract (HP:0002492)2.43732048
33Viral hepatitis (HP:0006562)2.43480831
34Narrow palate (HP:0000189)2.43393618
35Transitional cell carcinoma of the bladder (HP:0006740)2.42988988
36Central scotoma (HP:0000603)2.42417007
37Hyperacusis (HP:0010780)2.39109547
38Aqueductal stenosis (HP:0002410)2.39053171
39Ankle clonus (HP:0011448)2.38942351
40Abnormality of the phalanges of the hallux (HP:0010057)2.36872643
41Colitis (HP:0002583)2.36612538
42Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.35271604
43Focal seizures (HP:0007359)2.35099617
44Acute myeloid leukemia (HP:0004808)2.33740606
45Leiomyosarcoma (HP:0100243)2.31308276
46Uterine leiomyosarcoma (HP:0002891)2.31308276
47Bladder carcinoma (HP:0002862)2.30602826
48Bladder neoplasm (HP:0009725)2.30602826
49Apathy (HP:0000741)2.30425962
50IgM deficiency (HP:0002850)2.29299710
51Urinary urgency (HP:0000012)2.28559615
52Spastic gait (HP:0002064)2.27819602
53Truncal obesity (HP:0001956)2.25522214
54Abnormality of T cells (HP:0002843)2.25145841
55Absent frontal sinuses (HP:0002688)2.25143925
56Abnormal respiratory motile cilium physiology (HP:0012261)2.25118102
57Gingivitis (HP:0000230)2.22018963
58Gastrointestinal carcinoma (HP:0002672)2.21739738
59Malignant gastrointestinal tract tumors (HP:0006749)2.21739738
60Male infertility (HP:0003251)2.20748174
61Infertility (HP:0000789)2.20567827
62Abnormal rod and cone electroretinograms (HP:0008323)2.19845205
63Vertebral arch anomaly (HP:0008438)2.19120073
64Spinal cord lesions (HP:0100561)2.15847750
65Syringomyelia (HP:0003396)2.15847750
66Deep philtrum (HP:0002002)2.15286309
67Spondylolisthesis (HP:0003302)2.14306138
68Diminished motivation (HP:0000745)2.11981908
69Atonic seizures (HP:0010819)2.11846656
70Papilledema (HP:0001085)2.11702784
71Hand muscle atrophy (HP:0009130)2.11602675
72Failure to thrive in infancy (HP:0001531)2.11571539
73Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.11535239
74Recurrent bacterial skin infections (HP:0005406)2.10707835
75Rhinitis (HP:0012384)2.10377889
76Recurrent viral infections (HP:0004429)2.09681201
77Abnormality of incisor morphology (HP:0011063)2.09613931
78Neoplasm of the heart (HP:0100544)2.08684684
79Macroorchidism (HP:0000053)2.07019989
80Gaze-evoked nystagmus (HP:0000640)2.05848677
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.04276632
82Absent/shortened dynein arms (HP:0200106)2.04276632
83Impaired vibration sensation in the lower limbs (HP:0002166)2.02381061
84Absent rod-and cone-mediated responses on ERG (HP:0007688)2.00150068
85Persistence of primary teeth (HP:0006335)1.99669724
86Abnormal delayed hypersensitivity skin test (HP:0002963)1.99616645
87Recurrent abscess formation (HP:0002722)1.98976984
88Flat acetabular roof (HP:0003180)1.98812454
89Testicular neoplasm (HP:0010788)1.98625884
90Hemiplegia (HP:0002301)1.98569978
91Deep palmar crease (HP:0006191)1.98561238
92Thickened calvaria (HP:0002684)1.98471588
93Elfin facies (HP:0004428)1.98283152
94Nephroblastoma (Wilms tumor) (HP:0002667)1.98130731
95Dislocated radial head (HP:0003083)1.98059571
96Broad palm (HP:0001169)1.97785626
97Pointed chin (HP:0000307)1.97498461
98Basal cell carcinoma (HP:0002671)1.97476728
99Thyroid carcinoma (HP:0002890)1.97425131
100Inflammation of the large intestine (HP:0002037)1.93892406
101Abnormality of the fingertips (HP:0001211)1.93887618
102Abnormality of macular pigmentation (HP:0008002)1.93560377
103Conjunctival telangiectasia (HP:0000524)1.92127482
104Periodontitis (HP:0000704)1.91942998
105Bronchitis (HP:0012387)1.91930655
106Decreased motor nerve conduction velocity (HP:0003431)1.91801192
107Depression (HP:0000716)1.91747781
108Gastrointestinal infarctions (HP:0005244)1.91745784
109Pelvic girdle muscle weakness (HP:0003749)1.91352364
110Abnormality of the hip-girdle musculature (HP:0001445)1.90387333
111Abnormality of the musculature of the pelvis (HP:0001469)1.90387333
112Lymphopenia (HP:0001888)1.90115704
113Embryonal renal neoplasm (HP:0011794)1.89989289
114Gastrointestinal inflammation (HP:0004386)1.88971313
115Sandal gap (HP:0001852)1.88658359
116Recurrent fungal infections (HP:0002841)1.88406989
117Mitral valve prolapse (HP:0001634)1.88296474
118Overlapping toe (HP:0001845)1.87923039
119Aplasia/Hypoplasia of the brainstem (HP:0007362)1.87654792
120Hypoplasia of the brainstem (HP:0002365)1.87654792
121Ankyloglossia (HP:0010296)1.86151797
122Glucose intolerance (HP:0000833)1.85595680
123Osteolytic defects of the hand bones (HP:0009699)1.85544620
124Osteolytic defects of the phalanges of the hand (HP:0009771)1.85544620
125Distal upper limb amyotrophy (HP:0007149)1.85355063
126Upper limb amyotrophy (HP:0009129)1.85355063
127Chronic bronchitis (HP:0004469)1.85230669
128Abnormality of the distal phalanx of the thumb (HP:0009617)1.85060829
129Lower limb muscle weakness (HP:0007340)1.84771315
130Cellulitis (HP:0100658)1.83635031
131Chronic diarrhea (HP:0002028)1.83557500
132Febrile seizures (HP:0002373)1.83456309
133Overriding aorta (HP:0002623)1.83120083
134Increased nuchal translucency (HP:0010880)1.82339556
135Scotoma (HP:0000575)1.80941587
136Type II diabetes mellitus (HP:0005978)1.80127901
137Peripheral hypomyelination (HP:0007182)1.80099419
138Recurrent gram-negative bacterial infections (HP:0005420)1.79916844
139Astrocytoma (HP:0009592)1.79827528
140Abnormality of the astrocytes (HP:0100707)1.79827528
141Hemiparesis (HP:0001269)1.78253338
142Long eyelashes (HP:0000527)1.77932806
143Abnormality of cells of the lymphoid lineage (HP:0012140)1.77069249
144Slow saccadic eye movements (HP:0000514)1.76723011
145Recurrent sinusitis (HP:0011108)1.76319037
146Sacral dimple (HP:0000960)1.76100216
147Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75965504
148Osteomyelitis (HP:0002754)1.75771837
149Dysmetria (HP:0001310)1.75768634
150Mask-like facies (HP:0000298)1.75765064
151Postural instability (HP:0002172)1.74434644
152Pheochromocytoma (HP:0002666)1.74372587
153Hematochezia (HP:0002573)1.74360163
154Abnormality of the radial head (HP:0003995)1.74341758
155Gonadal dysgenesis (HP:0000133)1.73703572
156Cerebral aneurysm (HP:0004944)1.72937359
157Dilatation of the ascending aorta (HP:0005111)1.72827030
158Intention tremor (HP:0002080)1.71756082
159Attenuation of retinal blood vessels (HP:0007843)1.71624380
160Menstrual irregularities (HP:0000858)1.71384625
161Renovascular hypertension (HP:0100817)1.70269480
162Panhypogammaglobulinemia (HP:0003139)1.70148991
163Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69900616
164Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.68914567
165Fatigue (HP:0012378)1.68395758
166Pustule (HP:0200039)1.68130481
167Arterial tortuosity (HP:0005116)1.67653126
168Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.66794111
169Degeneration of the lateral corticospinal tracts (HP:0002314)1.66794111
170Trigonocephaly (HP:0000243)1.66713699
171Abnormality of oral frenula (HP:0000190)1.66566221
172Abnormality of saccadic eye movements (HP:0000570)1.65981865
173Papilloma (HP:0012740)1.65239577
174Verrucae (HP:0200043)1.65239577
175Specific learning disability (HP:0001328)1.64312290
176Coarse hair (HP:0002208)1.64119248
177Short 4th metacarpal (HP:0010044)1.64059125
178Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.64059125
179Neonatal hypoglycemia (HP:0001998)1.64009842
180Bundle branch block (HP:0011710)1.63121335
181Morphological abnormality of the pyramidal tract (HP:0002062)1.63054136
182Relative macrocephaly (HP:0004482)1.62638755
183Capillary hemangiomas (HP:0005306)1.62362016
184Ulnar claw (HP:0001178)1.62056171
185Progressive inability to walk (HP:0002505)1.61909742
186Abnormality of the labia minora (HP:0012880)1.61176131
187Obsessive-compulsive behavior (HP:0000722)1.61160763

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.68769949
2PRKD33.30419914
3PRPF4B3.12243515
4MARK12.59773210
5KSR22.53920888
6EEF2K2.41096015
7NLK2.28241112
8PNCK2.15899467
9LATS22.09184367
10MAP3K42.00268730
11CDC71.98124207
12MAP3K131.90194173
13PAK61.89547776
14BLK1.80918559
15MAP3K141.80267111
16MAP3K101.79443189
17NTRK31.74337117
18MINK11.66993066
19CDK121.64456693
20NTRK21.63850973
21CAMKK21.62856434
22STK381.58810923
23KSR11.57976071
24ICK1.55678487
25JAK11.51203760
26WNK11.48776119
27RIPK41.44965366
28YES11.43348276
29MAP3K21.42063380
30TYRO31.38989726
31NTRK11.38349855
32BTK1.37427530
33TAOK31.37341399
34PRKCH1.35310016
35ALK1.34811833
36NEK91.30303321
37CSK1.29425392
38RET1.29169921
39SIK31.28708945
40NEK21.28664280
41TXK1.26438863
42TYK21.25168708
43CDK61.25028841
44STK101.24995816
45TAF11.24641905
46PASK1.24369185
47RIPK11.23584178
48JAK31.23001221
49TEC1.21208671
50NEK61.20981666
51MAPK131.20597821
52MARK21.20397159
53CAMK1D1.18606428
54ZAP701.13869671
55AKT31.11231589
56MAP2K71.10357818
57MAP4K11.10356128
58PDK31.09722528
59PDK41.09722528
60MAP2K31.09488425
61STK111.09360922
62CDK41.09338485
63MAP2K41.07881453
64HCK1.03088358
65FGFR41.02917124
66ACVR1B1.02678558
67TAOK11.02648354
68LMTK21.00624353
69GRK61.00266329
70STK240.98079795
71CAMK1G0.95440149
72SMG10.94730275
73CSNK1G20.93020492
74CDK50.92238242
75UHMK10.91910543
76SCYL20.91710049
77PIM10.90076049
78MARK30.88601416
79SGK4940.88461983
80SGK2230.88461983
81STK38L0.88141820
82BRD40.87146506
83RAF10.84234369
84SGK30.83724514
85SIK20.82133550
86PDGFRA0.81796609
87IRAK40.80234942
88MAP2K60.79963107
89EIF2AK30.79542543
90MAPK100.77431397
91PDGFRB0.77351938
92LCK0.77330395
93TRPM70.76619295
94BMPR20.74923357
95SYK0.73760991
96IKBKE0.73178616
97ITK0.72732763
98CAMK40.72519080
99DYRK20.71297349
100MELK0.70415749
101CSNK1G30.69944059
102IRAK10.68926385
103PHKG10.67956954
104PHKG20.67956954
105JAK20.67564215
106FGFR20.66773049
107LATS10.66470027
108TGFBR20.66045625
109PIK3CG0.65967388
110MAP3K60.65817452
111BRAF0.63491456
112BRSK20.63384014
113MTOR0.63136743
114PDK10.63024723
115HIPK20.62765667
116CDK150.62054413
117CDK180.61896301
118NEK10.61489943
119SGK20.60207485
120CAMKK10.59939725
121MAPK80.59834349
122TESK10.59067188
123CHEK10.58988678
124CSNK1D0.58682512
125CDK140.57909488
126SGK10.57781839
127PDPK10.57215970
128CSNK1A1L0.56374305
129ERBB30.55071106
130GSK3B0.54996565
131STK40.53666537
132CDK11A0.53409446
133MAP3K80.53308416
134PTK2B0.53159685
135MAP3K10.52952509
136FGFR30.52206504
137MAP3K70.52050865
138RPS6KB20.51869805
139CDK90.51305840
140PAK30.51085768
141PRKCQ0.50039655
142MAPK70.49814376
143RPS6KA20.48975482
144CDK20.47621673
145TRIB30.47567908
146STK30.46959693
147CDK10.45886857
148DYRK1A0.45803629
149MAPK110.45742487
150PLK30.45664609
151PRKAA10.42887272
152PLK20.41613032
153FES0.40010968
154PTK60.38813551
155RPS6KA30.38562643
156CSNK1G10.38503189
157ATM0.37965968
158WNK30.37584758
159MAPK90.37458340
160MAPK140.36560162
161BRSK10.36271834

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047212.07970315
2Phototransduction_Homo sapiens_hsa047441.97286638
3Dorso-ventral axis formation_Homo sapiens_hsa043201.75340409
4Olfactory transduction_Homo sapiens_hsa047401.73747124
5Primary immunodeficiency_Homo sapiens_hsa053401.69582495
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64044055
7Measles_Homo sapiens_hsa051621.63958138
8Thyroid cancer_Homo sapiens_hsa052161.62996314
9Long-term potentiation_Homo sapiens_hsa047201.60730572
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.58008225
11Prostate cancer_Homo sapiens_hsa052151.56490861
12Dopaminergic synapse_Homo sapiens_hsa047281.56204664
13Phosphatidylinositol signaling system_Homo sapiens_hsa040701.50331256
14Oocyte meiosis_Homo sapiens_hsa041141.49639207
15Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.48446505
16Colorectal cancer_Homo sapiens_hsa052101.48048409
17Type II diabetes mellitus_Homo sapiens_hsa049301.47903063
18Cholinergic synapse_Homo sapiens_hsa047251.47157926
19Neurotrophin signaling pathway_Homo sapiens_hsa047221.43090716
20Endometrial cancer_Homo sapiens_hsa052131.40567053
21Circadian entrainment_Homo sapiens_hsa047131.38797358
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.38274607
23Renal cell carcinoma_Homo sapiens_hsa052111.37546743
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34417387
25GABAergic synapse_Homo sapiens_hsa047271.32540045
26Morphine addiction_Homo sapiens_hsa050321.31481431
27mTOR signaling pathway_Homo sapiens_hsa041501.30608237
28Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30521355
29Glutamatergic synapse_Homo sapiens_hsa047241.27419849
30Estrogen signaling pathway_Homo sapiens_hsa049151.27409496
31Leishmaniasis_Homo sapiens_hsa051401.26521716
32Insulin secretion_Homo sapiens_hsa049111.25884617
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.23867134
34T cell receptor signaling pathway_Homo sapiens_hsa046601.22834852
35ErbB signaling pathway_Homo sapiens_hsa040121.22700452
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22176796
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21389627
38Amphetamine addiction_Homo sapiens_hsa050311.21248239
39Glioma_Homo sapiens_hsa052141.21221774
40Chronic myeloid leukemia_Homo sapiens_hsa052201.20328022
41Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.19226283
42Adherens junction_Homo sapiens_hsa045201.17760547
43mRNA surveillance pathway_Homo sapiens_hsa030151.16722842
44Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16502970
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.14919237
46Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10634333
47Influenza A_Homo sapiens_hsa051641.10054541
48VEGF signaling pathway_Homo sapiens_hsa043701.10026012
49Nicotine addiction_Homo sapiens_hsa050331.09320085
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09012716
51Small cell lung cancer_Homo sapiens_hsa052221.08541404
52Toxoplasmosis_Homo sapiens_hsa051451.07767621
53MAPK signaling pathway_Homo sapiens_hsa040101.06412940
54Herpes simplex infection_Homo sapiens_hsa051681.05841350
55Proteoglycans in cancer_Homo sapiens_hsa052051.05143813
56Pancreatic cancer_Homo sapiens_hsa052121.03444032
57Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02586594
58Cocaine addiction_Homo sapiens_hsa050301.02496907
59Non-small cell lung cancer_Homo sapiens_hsa052231.02159358
60B cell receptor signaling pathway_Homo sapiens_hsa046621.01914181
61Prolactin signaling pathway_Homo sapiens_hsa049171.01621394
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01524045
63Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01361946
64Inositol phosphate metabolism_Homo sapiens_hsa005621.01163725
65GnRH signaling pathway_Homo sapiens_hsa049121.00799634
66TNF signaling pathway_Homo sapiens_hsa046681.00713383
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.00448782
68Oxytocin signaling pathway_Homo sapiens_hsa049210.99455750
69HTLV-I infection_Homo sapiens_hsa051660.99166296
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98434080
71Endocytosis_Homo sapiens_hsa041440.98430886
72Long-term depression_Homo sapiens_hsa047300.97902904
73Hematopoietic cell lineage_Homo sapiens_hsa046400.97563122
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.96444472
75Taste transduction_Homo sapiens_hsa047420.96340720
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.95980569
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95828131
78Renin secretion_Homo sapiens_hsa049240.95746564
79Gap junction_Homo sapiens_hsa045400.95026873
80FoxO signaling pathway_Homo sapiens_hsa040680.94944950
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90234389
82Choline metabolism in cancer_Homo sapiens_hsa052310.89325459
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.89003618
84Central carbon metabolism in cancer_Homo sapiens_hsa052300.88199517
85Gastric acid secretion_Homo sapiens_hsa049710.87674408
86Apoptosis_Homo sapiens_hsa042100.86713432
87cAMP signaling pathway_Homo sapiens_hsa040240.84542159
88Serotonergic synapse_Homo sapiens_hsa047260.84160328
89Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84122666
90Glucagon signaling pathway_Homo sapiens_hsa049220.83811799
91Hepatitis C_Homo sapiens_hsa051600.82047944
92Viral myocarditis_Homo sapiens_hsa054160.80268779
93Alcoholism_Homo sapiens_hsa050340.80070756
94Salivary secretion_Homo sapiens_hsa049700.79757951
95Tuberculosis_Homo sapiens_hsa051520.79569871
96Axon guidance_Homo sapiens_hsa043600.79006037
97Insulin signaling pathway_Homo sapiens_hsa049100.78624345
98Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77423873
99Chemokine signaling pathway_Homo sapiens_hsa040620.77373003
100Autoimmune thyroid disease_Homo sapiens_hsa053200.76621802
101Focal adhesion_Homo sapiens_hsa045100.76452740
102Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75919992
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75316605
104Cell cycle_Homo sapiens_hsa041100.73923959
105Melanoma_Homo sapiens_hsa052180.73440012
106Allograft rejection_Homo sapiens_hsa053300.73086613
107Ras signaling pathway_Homo sapiens_hsa040140.72536879
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71668272
109p53 signaling pathway_Homo sapiens_hsa041150.69969481
110Pathways in cancer_Homo sapiens_hsa052000.69158462
111Notch signaling pathway_Homo sapiens_hsa043300.68291569
112Graft-versus-host disease_Homo sapiens_hsa053320.67911924
113TGF-beta signaling pathway_Homo sapiens_hsa043500.67660729
114MicroRNAs in cancer_Homo sapiens_hsa052060.66932263
115HIF-1 signaling pathway_Homo sapiens_hsa040660.66883529
116Hippo signaling pathway_Homo sapiens_hsa043900.65885986
117Lysine degradation_Homo sapiens_hsa003100.65777162
118Rap1 signaling pathway_Homo sapiens_hsa040150.65176755
119Dilated cardiomyopathy_Homo sapiens_hsa054140.64671057
120Acute myeloid leukemia_Homo sapiens_hsa052210.62704174
121Melanogenesis_Homo sapiens_hsa049160.62141497
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.61853418
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.60581853
124Insulin resistance_Homo sapiens_hsa049310.60253794
125Circadian rhythm_Homo sapiens_hsa047100.60186245
126Osteoclast differentiation_Homo sapiens_hsa043800.59559868
127Wnt signaling pathway_Homo sapiens_hsa043100.58943559
128Amoebiasis_Homo sapiens_hsa051460.58612559
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57968746
130AMPK signaling pathway_Homo sapiens_hsa041520.57590290
131Platelet activation_Homo sapiens_hsa046110.57580193
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.57428011
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57177777
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56184800
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55967792
136Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55590084
137Epstein-Barr virus infection_Homo sapiens_hsa051690.55394778
138Viral carcinogenesis_Homo sapiens_hsa052030.55051250
139Hepatitis B_Homo sapiens_hsa051610.54134267
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53587942
141Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53372623
142PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51873807

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