CEP112

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil domain containing protein that belongs to the cell division control protein 42 effector protein family. In neurons, it localizes to the cytoplasm of dendrites and is also enriched in the nucleus where it interacts with the RNA polymerase III transcriptional repressor Maf1 to regulate gamma-aminobutyric acid A receptor surface expression. In addition, the protein has been identified as a component of the human centrosome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.24213852
2cell wall macromolecule metabolic process (GO:0044036)9.24213852
3cilium or flagellum-dependent cell motility (GO:0001539)8.71633451
4fusion of sperm to egg plasma membrane (GO:0007342)8.61130363
5sperm motility (GO:0030317)8.38055677
6epithelial cilium movement (GO:0003351)8.06697033
7acrosome assembly (GO:0001675)8.05804148
8axonemal dynein complex assembly (GO:0070286)7.59463406
9cilium movement (GO:0003341)7.49150898
10sperm-egg recognition (GO:0035036)7.47520776
11multicellular organism reproduction (GO:0032504)7.38164458
12acrosome reaction (GO:0007340)7.14903151
13binding of sperm to zona pellucida (GO:0007339)6.72638667
14motile cilium assembly (GO:0044458)6.64874862
15plasma membrane fusion (GO:0045026)6.64766251
16cell-cell recognition (GO:0009988)6.61561233
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.25878984
18reproduction (GO:0000003)6.10579551
19spermatid development (GO:0007286)6.08364218
20male meiosis (GO:0007140)5.50246818
21piRNA metabolic process (GO:0034587)5.30745400
22microtubule depolymerization (GO:0007019)5.30159959
23single fertilization (GO:0007338)5.04294544
24regulation of cilium movement (GO:0003352)5.03505299
25ventricular system development (GO:0021591)4.98733311
26synaptonemal complex organization (GO:0070193)4.78202256
27behavioral response to nicotine (GO:0035095)4.76799246
28synaptonemal complex assembly (GO:0007130)4.59303676
29spermatid nucleus differentiation (GO:0007289)4.28038717
30fertilization (GO:0009566)4.24318111
31spermatogenesis (GO:0007283)4.21843058
32male gamete generation (GO:0048232)4.20639297
33axoneme assembly (GO:0035082)4.03908462
34sperm capacitation (GO:0048240)4.03105925
35intraciliary transport (GO:0042073)3.98178755
36gonadal mesoderm development (GO:0007506)3.94899588
37gamete generation (GO:0007276)3.90576302
38germ cell development (GO:0007281)3.81064167
39cell recognition (GO:0008037)3.75492615
40DNA methylation involved in gamete generation (GO:0043046)3.70891035
41microtubule severing (GO:0051013)3.64695333
42cilium organization (GO:0044782)3.64573047
43GTP biosynthetic process (GO:0006183)3.61965269
44cellular process involved in reproduction in multicellular organism (GO:0022412)3.60912164
45response to pheromone (GO:0019236)3.60346603
46calcium ion-dependent exocytosis (GO:0017156)3.60319591
47L-fucose catabolic process (GO:0042355)3.58639090
48fucose catabolic process (GO:0019317)3.58639090
49L-fucose metabolic process (GO:0042354)3.58639090
50negative regulation of cytosolic calcium ion concentration (GO:0051481)3.56664162
51cilium assembly (GO:0042384)3.53079444
52chromosome organization involved in meiosis (GO:0070192)3.46781085
53mitotic sister chromatid cohesion (GO:0007064)3.42498026
54monoubiquitinated protein deubiquitination (GO:0035520)3.42391135
55detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.38645416
56nonmotile primary cilium assembly (GO:0035058)3.33841550
57protein K11-linked deubiquitination (GO:0035871)3.31591210
58cellular component assembly involved in morphogenesis (GO:0010927)3.30453018
59negative regulation of inclusion body assembly (GO:0090084)3.27781172
60UTP biosynthetic process (GO:0006228)3.23686898
61limb development (GO:0060173)3.23157420
62appendage development (GO:0048736)3.23157420
63protein localization to cilium (GO:0061512)3.18704758
64centriole replication (GO:0007099)3.17635116
65behavioral response to ethanol (GO:0048149)3.16199082
66meiotic nuclear division (GO:0007126)3.14653311
67regulation of centriole replication (GO:0046599)3.11693998
68multicellular organismal reproductive process (GO:0048609)3.11593392
69positive regulation of male gonad development (GO:2000020)3.09876626
70chromosome condensation (GO:0030261)3.06991445
71centriole assembly (GO:0098534)3.06482222
72cilium morphogenesis (GO:0060271)3.05435597
73positive regulation of mRNA processing (GO:0050685)3.04750010
74nucleoside diphosphate phosphorylation (GO:0006165)3.04451427
75regulation of inclusion body assembly (GO:0090083)3.01104597
76transmission of nerve impulse (GO:0019226)3.00586460
77DNA packaging (GO:0006323)3.00194922
78left/right axis specification (GO:0070986)2.99456868
79male meiosis I (GO:0007141)2.96975590
80single strand break repair (GO:0000012)2.95998769
81retinal cone cell development (GO:0046549)2.95013664
82cellular ketone body metabolic process (GO:0046950)2.94763161
83left/right pattern formation (GO:0060972)2.94244046
84genitalia morphogenesis (GO:0035112)2.92864312
85organic cation transport (GO:0015695)2.84074798
86replication fork processing (GO:0031297)2.82305459
87lactate metabolic process (GO:0006089)2.81863549
88UTP metabolic process (GO:0046051)2.81840606
89head development (GO:0060322)2.79093836
90glomerulus development (GO:0032835)2.77366211
91somite development (GO:0061053)2.76762390
92regulation of male gonad development (GO:2000018)2.76543279
93photoreceptor cell maintenance (GO:0045494)2.75141179
94microtubule-based movement (GO:0007018)2.75042446
95establishment of protein localization to Golgi (GO:0072600)2.74999321
96positive regulation of macrophage activation (GO:0043032)2.74722021
97kynurenine metabolic process (GO:0070189)2.72731979
98hindbrain development (GO:0030902)2.70614584
99ketone body metabolic process (GO:1902224)2.69414298
100nuclear pore complex assembly (GO:0051292)2.69292282
101tryptophan catabolic process (GO:0006569)2.68781826
102indole-containing compound catabolic process (GO:0042436)2.68781826
103indolalkylamine catabolic process (GO:0046218)2.68781826
104microtubule polymerization or depolymerization (GO:0031109)2.68362103
105indolalkylamine metabolic process (GO:0006586)2.68280285
106seminiferous tubule development (GO:0072520)2.67738808
107cornea development in camera-type eye (GO:0061303)2.67188882
108pyrimidine nucleobase catabolic process (GO:0006208)2.66375627
109water-soluble vitamin biosynthetic process (GO:0042364)2.65539884
110preassembly of GPI anchor in ER membrane (GO:0016254)2.65245547
111inner ear receptor stereocilium organization (GO:0060122)2.63061664
112kidney morphogenesis (GO:0060993)2.62023677
113detection of light stimulus involved in sensory perception (GO:0050962)2.61199291
114detection of light stimulus involved in visual perception (GO:0050908)2.61199291
115platelet dense granule organization (GO:0060155)2.60086195
116neuronal action potential (GO:0019228)2.59974380
117synaptic transmission, cholinergic (GO:0007271)2.59651450
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.59340220
119multicellular organismal development (GO:0007275)2.59300347
120guanosine-containing compound biosynthetic process (GO:1901070)2.59172513
121limb bud formation (GO:0060174)2.58835146
122regulation of action potential (GO:0098900)2.58667918
123positive regulation of RNA splicing (GO:0033120)2.58304460
124photoreceptor cell development (GO:0042461)2.56818900
125nephron epithelium morphogenesis (GO:0072088)2.55157279
126nephron tubule morphogenesis (GO:0072078)2.55157279
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.53284160
128mitochondrial respiratory chain complex I assembly (GO:0032981)2.53284160
129NADH dehydrogenase complex assembly (GO:0010257)2.53284160
130kinetochore organization (GO:0051383)2.52677530
131smoothened signaling pathway (GO:0007224)2.52572830
132reflex (GO:0060004)2.52422802
133neural tube formation (GO:0001841)2.51349870
134reciprocal DNA recombination (GO:0035825)2.50737373
135reciprocal meiotic recombination (GO:0007131)2.50737373
136paraxial mesoderm development (GO:0048339)2.50266042
137lymph vessel development (GO:0001945)2.50121774
138histone H3-K9 methylation (GO:0051567)2.47691348
139protein-cofactor linkage (GO:0018065)2.46252078
140meiotic cell cycle (GO:0051321)2.44148440
141regulation of microtubule-based movement (GO:0060632)2.43947033
142determination of left/right symmetry (GO:0007368)2.43205782
143protein complex biogenesis (GO:0070271)2.43007343
144regulation of spindle checkpoint (GO:0090231)2.42445103
145histone exchange (GO:0043486)2.41981623
146retinal ganglion cell axon guidance (GO:0031290)2.40815587
147regulation of hippo signaling (GO:0035330)2.40754694
148regulation of mesoderm development (GO:2000380)2.40721798
149glycerol ether metabolic process (GO:0006662)2.40340172
150negative regulation of DNA repair (GO:0045738)2.40126029
151dopamine transport (GO:0015872)2.39824794
152protein polyglutamylation (GO:0018095)2.39623520
153otic vesicle formation (GO:0030916)2.38592017
154gamma-aminobutyric acid transport (GO:0015812)2.38406163
155protein targeting to Golgi (GO:0000042)2.38148416
156pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.38143882
157negative regulation of axon extension involved in axon guidance (GO:0048843)2.37557235
158sister chromatid cohesion (GO:0007062)2.37424819
159regulation of hexokinase activity (GO:1903299)2.37037987
160regulation of glucokinase activity (GO:0033131)2.37037987
161G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.35174467
162startle response (GO:0001964)2.34824849
163postsynaptic membrane organization (GO:0001941)2.34591776
164respiratory chain complex IV assembly (GO:0008535)2.34414346
165protein K6-linked ubiquitination (GO:0085020)2.33101525
166spinal cord motor neuron differentiation (GO:0021522)2.30923487
167nucleobase catabolic process (GO:0046113)2.30358847
168determination of bilateral symmetry (GO:0009855)2.29100715
169cAMP catabolic process (GO:0006198)2.28113809
170protein localization to Golgi apparatus (GO:0034067)2.28107237
171resolution of meiotic recombination intermediates (GO:0000712)2.28078459
172recombinational repair (GO:0000725)2.27810580
173renal tubule morphogenesis (GO:0061333)2.27499359
174negative regulation of transcription regulatory region DNA binding (GO:2000678)2.26554337
175auditory receptor cell stereocilium organization (GO:0060088)2.26507596
176regulation of rhodopsin mediated signaling pathway (GO:0022400)2.26502144
177eye photoreceptor cell development (GO:0042462)2.26373266

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.09704416
2EZH2_22144423_ChIP-Seq_EOC_Human3.79097190
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.64133194
4CBX2_27304074_Chip-Seq_ESCs_Mouse2.62376606
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.60857448
6VDR_22108803_ChIP-Seq_LS180_Human2.58993497
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.47598188
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42945573
9GBX2_23144817_ChIP-Seq_PC3_Human2.41605391
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.36035911
11FUS_26573619_Chip-Seq_HEK293_Human2.32914353
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.25727197
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22423064
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10591429
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.05799304
16CTBP2_25329375_ChIP-Seq_LNCAP_Human1.97765106
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94036016
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.89841876
19KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.88022662
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.84460832
21RNF2_27304074_Chip-Seq_NSC_Mouse1.84281237
22TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.83974484
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.77550534
24TAF15_26573619_Chip-Seq_HEK293_Human1.74715326
25P300_19829295_ChIP-Seq_ESCs_Human1.71546631
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71188376
27SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.71156588
28BCAT_22108803_ChIP-Seq_LS180_Human1.69034209
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66776955
30SMAD4_21799915_ChIP-Seq_A2780_Human1.65394703
31NANOG_18555785_Chip-Seq_ESCs_Mouse1.61437881
32TAL1_26923725_Chip-Seq_HPCs_Mouse1.61075600
33MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.60295944
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59042472
35ZNF274_21170338_ChIP-Seq_K562_Hela1.58340091
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57105130
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55740080
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54869417
39EWS_26573619_Chip-Seq_HEK293_Human1.53524527
40TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.52895471
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52759164
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.52371305
43NFE2_27457419_Chip-Seq_LIVER_Mouse1.52154008
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.51762329
45RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50931502
46SOX9_26525672_Chip-Seq_HEART_Mouse1.50364742
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48704281
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46919683
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46560730
50MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.43564768
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.42825756
52TCF4_23295773_ChIP-Seq_U87_Human1.41463403
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40663204
54SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40141824
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.39187012
56P53_22387025_ChIP-Seq_ESCs_Mouse1.38448802
57EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37160986
58IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36876909
59CBP_20019798_ChIP-Seq_JUKART_Human1.36876909
60IRF1_19129219_ChIP-ChIP_H3396_Human1.36782601
61IGF1R_20145208_ChIP-Seq_DFB_Human1.36561161
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35608659
63TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35608659
64EP300_21415370_ChIP-Seq_HL-1_Mouse1.35326284
65CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35204269
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34840518
67KDM2B_26808549_Chip-Seq_REH_Human1.34211124
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.33833712
69FLI1_21867929_ChIP-Seq_TH2_Mouse1.31822028
70TCF4_22108803_ChIP-Seq_LS180_Human1.31794554
71NANOG_19829295_ChIP-Seq_ESCs_Human1.31224259
72SOX2_19829295_ChIP-Seq_ESCs_Human1.31224259
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.30584289
74NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.29824204
75E2F1_18555785_Chip-Seq_ESCs_Mouse1.29734388
76ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29076659
77CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.28829281
78RUNX2_22187159_ChIP-Seq_PCA_Human1.28372194
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.28053614
80TP53_22573176_ChIP-Seq_HFKS_Human1.27350316
81KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26830347
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25762930
83OCT4_18555785_Chip-Seq_ESCs_Mouse1.24213838
84EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24035641
85P300_18555785_Chip-Seq_ESCs_Mouse1.23653468
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.22801054
87SUZ12_18555785_Chip-Seq_ESCs_Mouse1.22640450
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22133858
89ER_23166858_ChIP-Seq_MCF-7_Human1.21981175
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.21028674
91HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19062743
92AR_21572438_ChIP-Seq_LNCaP_Human1.18927619
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.18885500
94STAT3_23295773_ChIP-Seq_U87_Human1.18139694
95MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16829849
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.16490727
97EED_16625203_ChIP-ChIP_MESCs_Mouse1.16030424
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.15482183
99REST_21632747_ChIP-Seq_MESCs_Mouse1.15266863
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.14663606
101AR_25329375_ChIP-Seq_VCAP_Human1.14580251
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13995554
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13821807
104LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12546883
105SOX2_18555785_Chip-Seq_ESCs_Mouse1.11995300
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10488347
107KAP1_22055183_ChIP-Seq_ESCs_Mouse1.10013541
108SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09835904
109RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.08296426
110GF1B_26923725_Chip-Seq_HPCs_Mouse1.08203785
111SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07931760
112ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07833196
113ARNT_22903824_ChIP-Seq_MCF-7_Human1.07723704
114WDR5_24793694_ChIP-Seq_LNCAP_Human1.07218399
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07159105
116PRDM14_20953172_ChIP-Seq_ESCs_Human1.07002404
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06879639
118KLF4_18555785_Chip-Seq_ESCs_Mouse1.05413336
119GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.05237786
120SOX2_21211035_ChIP-Seq_LN229_Gbm1.04185282
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.03832084
122FOXA1_27270436_Chip-Seq_PROSTATE_Human1.03832084
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03723770
124OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03534840
125NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02570092
126TP53_16413492_ChIP-PET_HCT116_Human1.01464487
127CDX2_22108803_ChIP-Seq_LS180_Human1.01366541
128ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01358673
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00793851
130POU5F1_16153702_ChIP-ChIP_HESCs_Human0.98960764
131MYC_18940864_ChIP-ChIP_HL60_Human0.98956118

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.78248758
2MP0003698_abnormal_male_reproductive3.47426380
3MP0008877_abnormal_DNA_methylation3.24707928
4MP0001929_abnormal_gametogenesis3.13796105
5MP0000569_abnormal_digit_pigmentation2.58673121
6MP0002653_abnormal_ependyma_morphology2.56280055
7MP0003195_calcinosis2.56269550
8MP0005503_abnormal_tendon_morphology2.53349309
9MP0003941_abnormal_skin_development2.51404455
10MP0002837_dystrophic_cardiac_calcinosis2.43635154
11MP0003122_maternal_imprinting2.34794459
12MP0002210_abnormal_sex_determination2.34703404
13MP0005623_abnormal_meninges_morphology2.21545128
14MP0003787_abnormal_imprinting2.05304711
15MP0003121_genomic_imprinting2.03355668
16MP0003646_muscle_fatigue1.98785269
17MP0002876_abnormal_thyroid_physiology1.91296699
18MP0001145_abnormal_male_reproductive1.87446684
19MP0002161_abnormal_fertility/fecundity1.85962747
20MP0003385_abnormal_body_wall1.84620701
21MP0002282_abnormal_trachea_morphology1.82089283
22MP0003890_abnormal_embryonic-extraembry1.71239887
23MP0000653_abnormal_sex_gland1.69592051
24MP0008057_abnormal_DNA_replication1.69303575
25MP0002102_abnormal_ear_morphology1.68554306
26MP0000372_irregular_coat_pigmentation1.68324001
27MP0001968_abnormal_touch/_nociception1.68064141
28MP0001984_abnormal_olfaction1.68038212
29MP0004272_abnormal_basement_membrane1.62752917
30MP0002638_abnormal_pupillary_reflex1.59514334
31MP0001879_abnormal_lymphatic_vessel1.57607828
32MP0001486_abnormal_startle_reflex1.56898375
33MP0001485_abnormal_pinna_reflex1.56510468
34MP0004215_abnormal_myocardial_fiber1.56450863
35MP0009780_abnormal_chondrocyte_physiolo1.55163584
36MP0005275_abnormal_skin_tensile1.54589278
37MP0003942_abnormal_urinary_system1.54236093
38MP0009250_abnormal_appendicular_skeleto1.53317320
39MP0009745_abnormal_behavioral_response1.52576492
40MP0003123_paternal_imprinting1.49040140
41MP0002272_abnormal_nervous_system1.48444493
42MP0003115_abnormal_respiratory_system1.48122489
43MP0004142_abnormal_muscle_tone1.46751641
44MP0004885_abnormal_endolymph1.45771701
45MP0004043_abnormal_pH_regulation1.41827449
46MP0003283_abnormal_digestive_organ1.41715911
47MP0005645_abnormal_hypothalamus_physiol1.37780992
48MP0003755_abnormal_palate_morphology1.32564843
49MP0006292_abnormal_olfactory_placode1.31489413
50MP0002938_white_spotting1.30278175
51MP0000427_abnormal_hair_cycle1.28882796
52MP0002108_abnormal_muscle_morphology1.28528752
53MP0004133_heterotaxia1.28336815
54MP0002160_abnormal_reproductive_system1.27721306
55MP0003937_abnormal_limbs/digits/tail_de1.26989334
56MP0001986_abnormal_taste_sensitivity1.26699822
57MP0001501_abnormal_sleep_pattern1.25928988
58MP0009384_cardiac_valve_regurgitation1.25159016
59MP0000049_abnormal_middle_ear1.24402050
60MP0008872_abnormal_physiological_respon1.23772063
61MP0010030_abnormal_orbit_morphology1.21782719
62MP0002736_abnormal_nociception_after1.21180508
63MP0001293_anophthalmia1.20764315
64MP0008775_abnormal_heart_ventricle1.20611443
65MP0000534_abnormal_ureter_morphology1.19288850
66MP0008058_abnormal_DNA_repair1.17981787
67MP0010368_abnormal_lymphatic_system1.16179257
68MP0004233_abnormal_muscle_weight1.16052180
69MP0005195_abnormal_posterior_eye1.15631547
70MP0002116_abnormal_craniofacial_bone1.14836764
71MP0002572_abnormal_emotion/affect_behav1.14430622
72MP0003935_abnormal_craniofacial_develop1.12956132
73MP0008875_abnormal_xenobiotic_pharmacok1.12553906
74MP0001188_hyperpigmentation1.12463766
75MP0000566_synostosis1.11892700
76MP0010386_abnormal_urinary_bladder1.10523860
77MP0004742_abnormal_vestibular_system1.09773403
78MP0003011_delayed_dark_adaptation1.09698528
79MP0009697_abnormal_copulation1.09666389
80MP0002752_abnormal_somatic_nervous1.08016078
81MP0005084_abnormal_gallbladder_morpholo1.07340593
82MP0001529_abnormal_vocalization1.06664279
83MP0002233_abnormal_nose_morphology1.06010547
84MP0000026_abnormal_inner_ear1.05015963
85MP0005423_abnormal_somatic_nervous1.03671129
86MP0002067_abnormal_sensory_capabilities1.01707549
87MP0000432_abnormal_head_morphology1.01411346
88MP0002734_abnormal_mechanical_nocicepti0.99850270
89MP0008995_early_reproductive_senescence0.99617038
90MP0003137_abnormal_impulse_conducting0.99024411
91MP0002109_abnormal_limb_morphology0.98788497
92MP0001970_abnormal_pain_threshold0.98134148
93MP0002932_abnormal_joint_morphology0.97979537
94MP0002733_abnormal_thermal_nociception0.97406778
95MP0008438_abnormal_cutaneous_collagen0.97170431
96MP0005386_behavior/neurological_phenoty0.96665747
97MP0004924_abnormal_behavior0.96665747
98MP0002184_abnormal_innervation0.95889207
99MP0005253_abnormal_eye_physiology0.95800309
100MP0004085_abnormal_heartbeat0.94006481
101MP0004084_abnormal_cardiac_muscle0.94000208
102MP0006138_congestive_heart_failure0.93979447
103MP0000647_abnormal_sebaceous_gland0.93268736
104MP0000631_abnormal_neuroendocrine_gland0.92987893
105MP0009046_muscle_twitch0.92608218
106MP0005551_abnormal_eye_electrophysiolog0.91917254
107MP0001963_abnormal_hearing_physiology0.91673223
108MP0003861_abnormal_nervous_system0.91285138
109MP0000749_muscle_degeneration0.91086053
110MP0002751_abnormal_autonomic_nervous0.90589892
111MP0002064_seizures0.90469551
112MP0006072_abnormal_retinal_apoptosis0.90054448
113MP0005379_endocrine/exocrine_gland_phen0.89251962
114MP0008007_abnormal_cellular_replicative0.89198479
115MP0009053_abnormal_anal_canal0.89065241
116MP0003880_abnormal_central_pattern0.88107769
117MP0000428_abnormal_craniofacial_morphol0.87928205
118MP0005646_abnormal_pituitary_gland0.87811017
119MP0003111_abnormal_nucleus_morphology0.86379892
120MP0004147_increased_porphyrin_level0.86356517
121MP0003718_maternal_effect0.86029363
122MP0005409_darkened_coat_color0.85619241
123MP0002249_abnormal_larynx_morphology0.85590250
124MP0005670_abnormal_white_adipose0.84950307
125MP0009379_abnormal_foot_pigmentation0.84096378
126MP0000230_abnormal_systemic_arterial0.83955645
127MP0002163_abnormal_gland_morphology0.83397509
128MP0002063_abnormal_learning/memory/cond0.83008594
129MP0000383_abnormal_hair_follicle0.82608940
130MP0005367_renal/urinary_system_phenotyp0.82590202
131MP0000516_abnormal_urinary_system0.82590202
132MP0010094_abnormal_chromosome_stability0.81513029
133MP0000778_abnormal_nervous_system0.81398893
134MP0003950_abnormal_plasma_membrane0.80762866
135MP0005391_vision/eye_phenotype0.80411596
136MP0002114_abnormal_axial_skeleton0.80123628
137MP0006276_abnormal_autonomic_nervous0.78299282
138MP0005389_reproductive_system_phenotype0.76730834
139MP0005394_taste/olfaction_phenotype0.75087206
140MP0005499_abnormal_olfactory_system0.75087206
141MP0002925_abnormal_cardiovascular_devel0.75059570
142MP0003119_abnormal_digestive_system0.73509963
143MP0002557_abnormal_social/conspecific_i0.70613888
144MP0001119_abnormal_female_reproductive0.69031332
145MP0002928_abnormal_bile_duct0.69023397
146MP0002177_abnormal_outer_ear0.67947973
147MP0005171_absent_coat_pigmentation0.67559504
148MP0001299_abnormal_eye_distance/0.66979416
149MP0001286_abnormal_eye_development0.66482044
150MP0002697_abnormal_eye_size0.65186678
151MP0002234_abnormal_pharynx_morphology0.64665926
152MP0008789_abnormal_olfactory_epithelium0.63478268
153MP0001502_abnormal_circadian_rhythm0.63378796
154MP0004145_abnormal_muscle_electrophysio0.62493291
155MP0003786_premature_aging0.62194893
156MP0003136_yellow_coat_color0.62189574
157MP0005187_abnormal_penis_morphology0.61850188
158MP0005508_abnormal_skeleton_morphology0.61358306
159MP0000762_abnormal_tongue_morphology0.61305755

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.08949356
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.89611171
3Absent/shortened dynein arms (HP:0200106)8.89611171
4Abnormal respiratory motile cilium physiology (HP:0012261)7.38493069
5Abnormal respiratory motile cilium morphology (HP:0005938)6.93947646
6Abnormal respiratory epithelium morphology (HP:0012253)6.93947646
7Abnormal ciliary motility (HP:0012262)6.72008020
8Rhinitis (HP:0012384)5.69767355
9Chronic bronchitis (HP:0004469)4.29651739
10Nephronophthisis (HP:0000090)4.11073197
11Abnormality of the renal cortex (HP:0011035)3.59580401
12Type II lissencephaly (HP:0007260)3.45886300
13Infertility (HP:0000789)3.25853928
14Medial flaring of the eyebrow (HP:0010747)3.21064577
15Intestinal atresia (HP:0011100)3.18164787
16Abnormality of the renal medulla (HP:0100957)3.12073502
17Congenital stationary night blindness (HP:0007642)3.09895010
18Abnormality of midbrain morphology (HP:0002418)2.97036285
19Molar tooth sign on MRI (HP:0002419)2.97036285
20Hyperventilation (HP:0002883)2.94918104
21True hermaphroditism (HP:0010459)2.92187880
22Pancreatic fibrosis (HP:0100732)2.74448493
23Volvulus (HP:0002580)2.73256395
24Bronchiectasis (HP:0002110)2.71151672
25Cerebellar dysplasia (HP:0007033)2.66413045
26Tubulointerstitial nephritis (HP:0001970)2.62658890
27Congenital primary aphakia (HP:0007707)2.61557071
28Renal cortical cysts (HP:0000803)2.60331631
29Polydipsia (HP:0001959)2.60136587
30Abnormal drinking behavior (HP:0030082)2.60136587
31Keratoconus (HP:0000563)2.59629557
32Increased corneal curvature (HP:0100692)2.59629557
33Gait imbalance (HP:0002141)2.58924790
34Nasal polyposis (HP:0100582)2.55424000
35Fibular hypoplasia (HP:0003038)2.55104755
36Tubular atrophy (HP:0000092)2.54086201
37Attenuation of retinal blood vessels (HP:0007843)2.53610577
38Abnormality of the nasal septum (HP:0000419)2.48265705
39Poor coordination (HP:0002370)2.43357679
40Genital tract atresia (HP:0001827)2.39896114
41Nephrogenic diabetes insipidus (HP:0009806)2.36396315
42Vaginal atresia (HP:0000148)2.34762810
43Impulsivity (HP:0100710)2.32141258
44Large for gestational age (HP:0001520)2.28176030
45Occipital encephalocele (HP:0002085)2.27484686
46Gaze-evoked nystagmus (HP:0000640)2.26655002
47Aplasia/Hypoplasia of the tongue (HP:0010295)2.26473244
48Cystic liver disease (HP:0006706)2.26224795
49Bifid tongue (HP:0010297)2.25895488
50Nephroblastoma (Wilms tumor) (HP:0002667)2.23175459
51Facial cleft (HP:0002006)2.23017794
52Pendular nystagmus (HP:0012043)2.22533343
53Postaxial foot polydactyly (HP:0001830)2.21210793
54Abnormality of the phalanges of the hallux (HP:0010057)2.18859532
55Lissencephaly (HP:0001339)2.18232074
56Oligodactyly (hands) (HP:0001180)2.18000805
57Aplasia/Hypoplasia of the lens (HP:0008063)2.17696340
58Congenital hepatic fibrosis (HP:0002612)2.14748716
59Abnormal rod and cone electroretinograms (HP:0008323)2.14647348
60Embryonal renal neoplasm (HP:0011794)2.14493696
61Pancreatic cysts (HP:0001737)2.14423589
62Furrowed tongue (HP:0000221)2.14129437
63Postaxial hand polydactyly (HP:0001162)2.11880727
64Abnormality of macular pigmentation (HP:0008002)2.11695509
65Thyroid-stimulating hormone excess (HP:0002925)2.10132588
66Abolished electroretinogram (ERG) (HP:0000550)2.09446834
67Supernumerary spleens (HP:0009799)2.06073961
68Abnormality of dentin (HP:0010299)2.05963161
69Microglossia (HP:0000171)2.04341408
70Median cleft lip (HP:0000161)2.03941718
71Male pseudohermaphroditism (HP:0000037)2.03660285
72Progressive cerebellar ataxia (HP:0002073)2.03062308
73Congenital, generalized hypertrichosis (HP:0004540)2.02941816
74Recurrent sinusitis (HP:0011108)2.02325470
75Bronchitis (HP:0012387)2.02230251
76Polyuria (HP:0000103)2.02078737
77Gastrointestinal atresia (HP:0002589)2.01570282
78Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01223338
79Renal dysplasia (HP:0000110)2.00333239
80Abnormality of the nasal mucosa (HP:0000433)2.00037928
81Dandy-Walker malformation (HP:0001305)1.95996147
82Inability to walk (HP:0002540)1.94984643
83Severe muscular hypotonia (HP:0006829)1.91186870
84Bile duct proliferation (HP:0001408)1.90741806
85Abnormal biliary tract physiology (HP:0012439)1.90741806
86Hypoplastic ischia (HP:0003175)1.90418706
87Chronic hepatic failure (HP:0100626)1.90123933
88Stage 5 chronic kidney disease (HP:0003774)1.89769733
89Midline defect of the nose (HP:0004122)1.89633653
90Chorioretinal atrophy (HP:0000533)1.89499993
91Calf muscle hypertrophy (HP:0008981)1.88624754
92Absent eyebrow (HP:0002223)1.87761726
93Preaxial hand polydactyly (HP:0001177)1.87549632
94Abnormality of the nasolacrimal system (HP:0000614)1.86457864
95Pachygyria (HP:0001302)1.85629627
96Left ventricular hypertrophy (HP:0001712)1.85463616
97Abnormality of the labia minora (HP:0012880)1.82083875
98Astigmatism (HP:0000483)1.81775462
99Progressive inability to walk (HP:0002505)1.81515685
100Decreased central vision (HP:0007663)1.81411185
101Abnormality of alanine metabolism (HP:0010916)1.80645555
102Hyperalaninemia (HP:0003348)1.80645555
103Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80645555
104Broad-based gait (HP:0002136)1.80643147
105Abnormality of the ischium (HP:0003174)1.79385518
106Broad toe (HP:0001837)1.78257176
107Abnormal hair whorl (HP:0010721)1.78193620
108Aplasia/Hypoplasia of the spleen (HP:0010451)1.78091400
109Abnormality of the lacrimal duct (HP:0011481)1.77447797
110Abnormality of the aortic arch (HP:0012303)1.76355518
111Dyschromatopsia (HP:0007641)1.75949293
112Congenital sensorineural hearing impairment (HP:0008527)1.75790049
113Aplasia/Hypoplasia of the fovea (HP:0008060)1.75626867
114Hypoplasia of the fovea (HP:0007750)1.75626867
115Genetic anticipation (HP:0003743)1.75478536
116Acute necrotizing encephalopathy (HP:0006965)1.74903994
117Aplasia/Hypoplasia of the fibula (HP:0006492)1.74376511
118Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73264793
119Short 4th metacarpal (HP:0010044)1.73264793
120Aplasia/Hypoplasia of the uvula (HP:0010293)1.72766445
121Abnormal spermatogenesis (HP:0008669)1.72603813
122Narrow forehead (HP:0000341)1.72106509
123Bell-shaped thorax (HP:0001591)1.71981328
124Retinal dysplasia (HP:0007973)1.71528919
125Bony spicule pigmentary retinopathy (HP:0007737)1.71350186
126Acute encephalopathy (HP:0006846)1.70640431
127Dental crowding (HP:0000678)1.70538990
128Abnormality of incisor morphology (HP:0011063)1.70341077
129Aplasia/Hypoplasia of the tibia (HP:0005772)1.70091571
130Aganglionic megacolon (HP:0002251)1.70030861
131Short ribs (HP:0000773)1.69633767
132Type 2 muscle fiber atrophy (HP:0003554)1.69445199
133Abnormality of the parietal bone (HP:0002696)1.66183553
134Tubulointerstitial abnormality (HP:0001969)1.65124033
135Dislocated radial head (HP:0003083)1.62796666
136Truncal obesity (HP:0001956)1.61687642
137Gonadotropin excess (HP:0000837)1.60020687
138Sclerocornea (HP:0000647)1.59901570
139Male infertility (HP:0003251)1.59740847
140Short tibia (HP:0005736)1.56977446
141Renal duplication (HP:0000075)1.56670931
142Double outlet right ventricle (HP:0001719)1.55649741
143Congenital malformation of the right heart (HP:0011723)1.55649741
144Ectopic kidney (HP:0000086)1.53904337
145Abnormality of the radial head (HP:0003995)1.53353604
146Mesomelia (HP:0003027)1.51117365
147Abnormal lung lobation (HP:0002101)1.48803432
148Nasolacrimal duct obstruction (HP:0000579)1.48331898
149Short foot (HP:0001773)1.46788358
150Ectopic anus (HP:0004397)1.45732985
151Optic nerve hypoplasia (HP:0000609)1.44923716
152Abnormality of the dental root (HP:0006486)1.44187358
153Taurodontia (HP:0000679)1.44187358
154Abnormality of permanent molar morphology (HP:0011071)1.44187358
155Recurrent otitis media (HP:0000403)1.44160415
156Anencephaly (HP:0002323)1.43402105
157Abnormality of the distal phalanx of the thumb (HP:0009617)1.42823451
158Highly arched eyebrow (HP:0002553)1.42506555
159Oculomotor apraxia (HP:0000657)1.41918496
160Anophthalmia (HP:0000528)1.41198431
161Chronic sinusitis (HP:0011109)1.40887428

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.23908856
2PDK46.23908856
3FRK5.09719198
4PDK24.56867511
5PRKD33.28099483
6TIE12.83930427
7MAP4K22.65731564
8ZAK2.24109592
9TESK12.16467701
10PNCK2.14519806
11PINK12.08972769
12LATS12.03511106
13PTK2B1.90591524
14ERBB31.82012459
15MUSK1.69284306
16AKT31.62859083
17ICK1.61865464
18CDC71.58693467
19TRIM281.46007011
20TLK11.41572340
21CCNB11.40405531
22NEK21.38791460
23BRD41.37549777
24PAK31.33384035
25MAPK151.30535101
26MARK11.28124413
27NEK61.26569979
28PHKG11.26170860
29PHKG21.26170860
30CASK1.23544563
31CDK121.18313091
32OXSR11.18185496
33PLK41.16384037
34ADRBK11.15226263
35STK38L1.14513780
36CSNK1G11.11640131
37PRKCE1.07777326
38SGK21.07214611
39WNK41.04835777
40TGFBR11.03517306
41CSNK1G21.03256625
42TAOK31.02765555
43PLK30.99900587
44BCR0.98534727
45DYRK20.96617380
46MKNK20.96293646
47TTK0.96194003
48CAMK1G0.94683266
49PIK3CA0.94438200
50MKNK10.94209295
51CSNK1G30.93878818
52ACVR1B0.91423114
53EPHA40.91076753
54CSNK1A1L0.90544381
55STK30.90371172
56ADRBK20.89650238
57CHEK20.88118150
58IRAK10.86382201
59VRK10.86381681
60MAP2K70.83523495
61WEE10.80349424
62SIK30.80324622
63OBSCN0.79388628
64DYRK30.79149989
65MAPK130.77975017
66CAMK40.77326117
67PLK20.76866097
68CDC42BPA0.76686093
69CDK30.76586386
70SIK20.75354230
71TNIK0.74751850
72STK380.74060112
73STK390.72511509
74YES10.71599358
75NTRK30.70883971
76FER0.70070526
77FGFR20.69731153
78ATR0.69214714
79NLK0.66014360
80EPHA30.64126113
81BMPR1B0.63803885
82PKN10.63647327
83ATM0.62830580
84PLK10.62594036
85SGK4940.62129165
86SGK2230.62129165
87CHEK10.61724178
88TSSK60.61035960
89BRSK20.60604768
90WNK30.59514640
91DAPK20.59469320
92PDGFRA0.58723420
93INSRR0.58426877
94NTRK20.58089124
95MST40.57759410
96TGFBR20.57579679
97DYRK1B0.57518000
98SGK30.57149443
99CAMK10.56447596
100EIF2AK30.55972134
101EIF2AK20.52950693
102NEK10.51980507
103GRK10.51925639
104GRK70.51495083
105WNK10.51234746
106NUAK10.50873078
107BCKDK0.48873984
108CDK10.48647790
109LIMK10.48462396
110CAMK1D0.47521394
111PDK10.47051094
112EPHB20.46830704
113FGFR10.46110014
114SRPK10.46105677
115MAP3K40.45770093
116MAPKAPK30.45162373
117PRKACA0.45030546
118GSK3B0.44857388
119STK110.44807658
120BRAF0.43056936
121AURKB0.42762819
122CAMKK20.41781221
123PRKAA10.41222008
124ROCK10.40134173
125PRPF4B0.39803035
126PRKCG0.38799006
127CSNK1D0.38299996
128CDK70.38148009
129CSNK1A10.37739827
130MARK20.37368944
131STK160.37287178
132PRKG10.36373961
133MTOR0.36353245
134CAMK2D0.35901162
135MAP2K60.35269782
136CAMK2A0.34997957
137CDK20.34097293
138PRKAA20.33883851
139DYRK1A0.33819022
140MYLK0.33795856
141ERBB20.32944383
142LMTK20.32779066
143PRKACB0.32452495
144RPS6KB10.32271849
145MAPKAPK50.31806498
146RPS6KA50.31527079
147TEC0.31479801

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.84980243
2Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.44780283
3Butanoate metabolism_Homo sapiens_hsa006502.35180565
4Fanconi anemia pathway_Homo sapiens_hsa034602.32832282
5Nitrogen metabolism_Homo sapiens_hsa009102.29726869
6Hedgehog signaling pathway_Homo sapiens_hsa043402.29023090
7Protein export_Homo sapiens_hsa030602.17422476
8Nicotine addiction_Homo sapiens_hsa050332.08141856
9Basal cell carcinoma_Homo sapiens_hsa052172.08120105
10Oxidative phosphorylation_Homo sapiens_hsa001902.06006886
11Propanoate metabolism_Homo sapiens_hsa006401.97762671
12Glucagon signaling pathway_Homo sapiens_hsa049221.93761752
13Basal transcription factors_Homo sapiens_hsa030221.93215423
14Amphetamine addiction_Homo sapiens_hsa050311.92193866
15Oocyte meiosis_Homo sapiens_hsa041141.91386216
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81900954
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.79319042
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.79259782
19Fatty acid biosynthesis_Homo sapiens_hsa000611.77221595
20TGF-beta signaling pathway_Homo sapiens_hsa043501.74051833
21Selenocompound metabolism_Homo sapiens_hsa004501.70362069
22Cell cycle_Homo sapiens_hsa041101.70228273
23Tryptophan metabolism_Homo sapiens_hsa003801.69968165
24Long-term potentiation_Homo sapiens_hsa047201.66687692
25Insulin secretion_Homo sapiens_hsa049111.66000660
26Wnt signaling pathway_Homo sapiens_hsa043101.63163261
27Circadian entrainment_Homo sapiens_hsa047131.62746868
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.61918151
29Parkinsons disease_Homo sapiens_hsa050121.61103176
30Adherens junction_Homo sapiens_hsa045201.57855208
31Taste transduction_Homo sapiens_hsa047421.55287410
32Caffeine metabolism_Homo sapiens_hsa002321.46060721
33Huntingtons disease_Homo sapiens_hsa050161.45847738
34Renin secretion_Homo sapiens_hsa049241.44959670
35Dorso-ventral axis formation_Homo sapiens_hsa043201.43554148
36Morphine addiction_Homo sapiens_hsa050321.39608276
37Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.38533240
38Cardiac muscle contraction_Homo sapiens_hsa042601.33489792
39Melanogenesis_Homo sapiens_hsa049161.33274387
40Calcium signaling pathway_Homo sapiens_hsa040201.32759896
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32611600
42mRNA surveillance pathway_Homo sapiens_hsa030151.32370877
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30765404
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.30408562
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.28573059
46Spliceosome_Homo sapiens_hsa030401.26657493
47Peroxisome_Homo sapiens_hsa041461.25347883
48Hippo signaling pathway_Homo sapiens_hsa043901.24922702
49Pyruvate metabolism_Homo sapiens_hsa006201.23061818
50Phototransduction_Homo sapiens_hsa047441.20875193
51Homologous recombination_Homo sapiens_hsa034401.19510840
52Aldosterone synthesis and secretion_Homo sapiens_hsa049251.18933470
53Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.18501362
54Olfactory transduction_Homo sapiens_hsa047401.17569780
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.17372589
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.16858061
57RNA degradation_Homo sapiens_hsa030181.16792773
58Dilated cardiomyopathy_Homo sapiens_hsa054141.16416301
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16393989
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15418859
61cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14653586
62ABC transporters_Homo sapiens_hsa020101.14117874
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13560969
64RNA transport_Homo sapiens_hsa030131.13401998
65Alzheimers disease_Homo sapiens_hsa050101.13047243
66Linoleic acid metabolism_Homo sapiens_hsa005911.12856682
67Estrogen signaling pathway_Homo sapiens_hsa049151.08267052
68Axon guidance_Homo sapiens_hsa043601.07787064
69Glutamatergic synapse_Homo sapiens_hsa047241.07621979
70beta-Alanine metabolism_Homo sapiens_hsa004101.05185989
71cAMP signaling pathway_Homo sapiens_hsa040241.04817660
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.03459680
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03251265
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02913635
75Vascular smooth muscle contraction_Homo sapiens_hsa042701.02745482
76Thyroid hormone synthesis_Homo sapiens_hsa049181.02426296
77Steroid biosynthesis_Homo sapiens_hsa001001.02087412
78Circadian rhythm_Homo sapiens_hsa047101.01874320
79Salivary secretion_Homo sapiens_hsa049701.01453584
80Chemical carcinogenesis_Homo sapiens_hsa052041.00355893
81ECM-receptor interaction_Homo sapiens_hsa045120.98723949
82RNA polymerase_Homo sapiens_hsa030200.98578137
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98053903
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.97974224
85Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96396678
86GABAergic synapse_Homo sapiens_hsa047270.95156635
87Non-homologous end-joining_Homo sapiens_hsa034500.95090013
88Purine metabolism_Homo sapiens_hsa002300.94980359
89Regulation of autophagy_Homo sapiens_hsa041400.93424257
90Cocaine addiction_Homo sapiens_hsa050300.93334925
91Gastric acid secretion_Homo sapiens_hsa049710.92615071
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92025298
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.90811010
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.90588670
95Retinol metabolism_Homo sapiens_hsa008300.88933647
96Ovarian steroidogenesis_Homo sapiens_hsa049130.87597982
97MicroRNAs in cancer_Homo sapiens_hsa052060.86187966
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.85657203
99Notch signaling pathway_Homo sapiens_hsa043300.85430587
100Arachidonic acid metabolism_Homo sapiens_hsa005900.81641368
101Oxytocin signaling pathway_Homo sapiens_hsa049210.80237504
102Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79394628
103Prostate cancer_Homo sapiens_hsa052150.77808043
104Histidine metabolism_Homo sapiens_hsa003400.77277537
105HTLV-I infection_Homo sapiens_hsa051660.77205040
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75234613
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74925822
108Glycerolipid metabolism_Homo sapiens_hsa005610.74556486
109One carbon pool by folate_Homo sapiens_hsa006700.74193107
110Lysine degradation_Homo sapiens_hsa003100.73064904
111Gap junction_Homo sapiens_hsa045400.72444146
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72209351
113Fatty acid degradation_Homo sapiens_hsa000710.68467767
114Protein digestion and absorption_Homo sapiens_hsa049740.67000621
115Serotonergic synapse_Homo sapiens_hsa047260.66902919
116Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66754286
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66424590
118Dopaminergic synapse_Homo sapiens_hsa047280.64579081
119Base excision repair_Homo sapiens_hsa034100.64460914
120Pathways in cancer_Homo sapiens_hsa052000.63811172
121Focal adhesion_Homo sapiens_hsa045100.62733753
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.62110990
123Sulfur metabolism_Homo sapiens_hsa009200.61957825
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61353891
125Tight junction_Homo sapiens_hsa045300.61105368
126Metabolic pathways_Homo sapiens_hsa011000.59605161
127Melanoma_Homo sapiens_hsa052180.59531101
128Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59148577
129Fat digestion and absorption_Homo sapiens_hsa049750.58773180
130Rap1 signaling pathway_Homo sapiens_hsa040150.57063495
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56841139
132Arginine and proline metabolism_Homo sapiens_hsa003300.56752291
133Nucleotide excision repair_Homo sapiens_hsa034200.56629269
134HIF-1 signaling pathway_Homo sapiens_hsa040660.54298374
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52583291
136Mismatch repair_Homo sapiens_hsa034300.52061629
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51976168
138Ether lipid metabolism_Homo sapiens_hsa005650.51166088
139p53 signaling pathway_Homo sapiens_hsa041150.50931835
140Mineral absorption_Homo sapiens_hsa049780.49835647
141Fatty acid metabolism_Homo sapiens_hsa012120.49587342
142Alcoholism_Homo sapiens_hsa050340.49022790
143Fatty acid elongation_Homo sapiens_hsa000620.48408591
144Proteoglycans in cancer_Homo sapiens_hsa052050.46185726
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45574176
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45509003
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.45386272
148Long-term depression_Homo sapiens_hsa047300.44875832
149Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.44542806
150Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44078198
151Collecting duct acid secretion_Homo sapiens_hsa049660.43612827
152Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38451284

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