CENPQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* CENP-A containing nucleosome assembly (GO:0034080)4.91060539
2DNA double-strand break processing (GO:0000729)4.86717073
3kinetochore organization (GO:0051383)4.81481273
4* chromatin remodeling at centromere (GO:0031055)4.73068438
5DNA strand elongation involved in DNA replication (GO:0006271)4.58826955
6telomere maintenance via semi-conservative replication (GO:0032201)4.53887671
7mitotic metaphase plate congression (GO:0007080)4.50543678
8ribosomal small subunit assembly (GO:0000028)4.47847728
9DNA strand elongation (GO:0022616)4.40534620
10attachment of spindle microtubules to kinetochore (GO:0008608)4.36866562
11DNA replication initiation (GO:0006270)4.35325179
12telomere maintenance via recombination (GO:0000722)4.29810145
13kinetochore assembly (GO:0051382)4.29128473
14protein localization to kinetochore (GO:0034501)4.27954207
15DNA replication checkpoint (GO:0000076)4.22967567
16* DNA replication-independent nucleosome assembly (GO:0006336)4.18411830
17* DNA replication-independent nucleosome organization (GO:0034724)4.18411830
18mitotic recombination (GO:0006312)4.12645017
19protein localization to chromosome, centromeric region (GO:0071459)4.06887732
20metaphase plate congression (GO:0051310)4.04730028
21meiotic chromosome segregation (GO:0045132)3.97432322
22* histone exchange (GO:0043486)3.89119144
23DNA unwinding involved in DNA replication (GO:0006268)3.87916640
24establishment of chromosome localization (GO:0051303)3.86503888
25maturation of SSU-rRNA (GO:0030490)3.85732308
26regulation of centriole replication (GO:0046599)3.82790512
27regulation of DNA endoreduplication (GO:0032875)3.79910420
28mitotic chromosome condensation (GO:0007076)3.75566512
29DNA catabolic process, exonucleolytic (GO:0000738)3.74784939
30replication fork processing (GO:0031297)3.69740592
31negative regulation of DNA-dependent DNA replication (GO:2000104)3.67587007
32telomere maintenance via telomere lengthening (GO:0010833)3.67286497
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.64594698
34ribosomal small subunit biogenesis (GO:0042274)3.64180220
35mitotic sister chromatid segregation (GO:0000070)3.63004829
36nucleotide-excision repair, DNA gap filling (GO:0006297)3.55219385
37mitotic G2/M transition checkpoint (GO:0044818)3.48800360
38purine nucleobase biosynthetic process (GO:0009113)3.47246346
39somatic diversification of immune receptors via somatic mutation (GO:0002566)3.44367772
40somatic hypermutation of immunoglobulin genes (GO:0016446)3.44367772
41spindle checkpoint (GO:0031577)3.41460154
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38728046
43postreplication repair (GO:0006301)3.36866316
44sister chromatid segregation (GO:0000819)3.35931362
45DNA replication-dependent nucleosome assembly (GO:0006335)3.35254161
46DNA replication-dependent nucleosome organization (GO:0034723)3.35254161
47deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35233407
48maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.34536072
49DNA topological change (GO:0006265)3.34509612
50DNA strand renaturation (GO:0000733)3.33234516
51viral transcription (GO:0019083)3.32566448
52positive regulation of chromosome segregation (GO:0051984)3.32473973
53regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.31182302
54regulation of mitotic spindle checkpoint (GO:1903504)3.31182302
55translational termination (GO:0006415)3.28487045
56establishment of protein localization to mitochondrial membrane (GO:0090151)3.27263237
57transcription-coupled nucleotide-excision repair (GO:0006283)3.25458615
58microtubule depolymerization (GO:0007019)3.24734155
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.23839607
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.23839607
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.23839607
62negative regulation of sister chromatid segregation (GO:0033046)3.23839607
63mitotic sister chromatid cohesion (GO:0007064)3.23010132
64spindle assembly checkpoint (GO:0071173)3.22440938
65recombinational repair (GO:0000725)3.22382113
66regulation of spindle organization (GO:0090224)3.21787754
67resolution of meiotic recombination intermediates (GO:0000712)3.20292873
68negative regulation of chromosome segregation (GO:0051985)3.20154971
69establishment of viral latency (GO:0019043)3.18963629
70IMP biosynthetic process (GO:0006188)3.18363250
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.18150866
72double-strand break repair via homologous recombination (GO:0000724)3.18118754
73regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16931180
74regulation of chromosome segregation (GO:0051983)3.15915524
75ribosomal large subunit biogenesis (GO:0042273)3.15656144
76mitotic spindle assembly checkpoint (GO:0007094)3.14912359
77deoxyribonucleotide biosynthetic process (GO:0009263)3.12988832
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.12692344
79DNA ligation (GO:0006266)3.12549012
80chromosome segregation (GO:0007059)3.11009571
81mitotic spindle checkpoint (GO:0071174)3.10850623
82mismatch repair (GO:0006298)3.10676471
83DNA deamination (GO:0045006)3.10488825
84telomere organization (GO:0032200)3.10187110
857-methylguanosine mRNA capping (GO:0006370)3.10109663
86proteasome assembly (GO:0043248)3.10054909
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.09915714
88RNA capping (GO:0036260)3.09574599
897-methylguanosine RNA capping (GO:0009452)3.09574599
90telomere maintenance (GO:0000723)3.08418776
91regulation of helicase activity (GO:0051095)3.08219165
92ribonucleoprotein complex biogenesis (GO:0022613)3.07403164
93mitotic nuclear envelope disassembly (GO:0007077)3.07063569
94translesion synthesis (GO:0019985)3.05804081
95regulation of centrosome cycle (GO:0046605)3.05355587
96regulation of sister chromatid segregation (GO:0033045)3.04875416
97regulation of mitotic sister chromatid separation (GO:0010965)3.04875416
98regulation of mitotic sister chromatid segregation (GO:0033047)3.04875416
99establishment of integrated proviral latency (GO:0075713)3.04237245
100double-strand break repair via nonhomologous end joining (GO:0006303)3.03392377
101non-recombinational repair (GO:0000726)3.03392377
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.03217563
103folic acid-containing compound biosynthetic process (GO:0009396)3.02622642
104negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02512729
105chaperone-mediated protein transport (GO:0072321)2.99718123
106base-excision repair (GO:0006284)2.98090197
107* mitotic cell cycle (GO:0000278)2.97480137
108negative regulation of ligase activity (GO:0051352)2.96223780
109negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.96223780
110regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.95743016
111rRNA processing (GO:0006364)2.95353077
112SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.94597410
113cotranslational protein targeting to membrane (GO:0006613)2.92091026
114spliceosomal snRNP assembly (GO:0000387)2.92030188
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91092538
116nucleobase biosynthetic process (GO:0046112)2.90652224
117DNA synthesis involved in DNA repair (GO:0000731)2.90012083
118regulation of double-strand break repair via homologous recombination (GO:0010569)2.89614093
119protein localization to chromosome (GO:0034502)2.89072202
120* chromatin assembly or disassembly (GO:0006333)2.87850983
121translational elongation (GO:0006414)2.87707260
122G1/S transition of mitotic cell cycle (GO:0000082)2.87432426
123cell cycle G1/S phase transition (GO:0044843)2.87432426
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86874583
125protein targeting to ER (GO:0045047)2.86843661
126ribosome assembly (GO:0042255)2.85708023
127rRNA metabolic process (GO:0016072)2.84663784
128positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.84418677
129positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.84418677
130positive regulation of mitotic sister chromatid separation (GO:1901970)2.84418677
131termination of RNA polymerase III transcription (GO:0006386)2.84382151
132transcription elongation from RNA polymerase III promoter (GO:0006385)2.84382151
133nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84161317
134spliceosomal complex assembly (GO:0000245)2.83702043
135protein K6-linked ubiquitination (GO:0085020)2.82733863

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.87834618
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.72848895
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.16252358
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.80159409
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.73769877
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.73765892
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.31188253
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.18477888
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92228427
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.79805674
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79800489
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78094941
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.67464926
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.62881812
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.61796404
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55872641
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54737803
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50607265
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49256283
20VDR_23849224_ChIP-Seq_CD4+_Human2.43961361
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.38681801
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38172664
23AR_21909140_ChIP-Seq_LNCAP_Human2.37795104
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34941523
25NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31541301
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.21117172
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.14088517
28FOXP3_21729870_ChIP-Seq_TREG_Human2.12589110
29ELK1_19687146_ChIP-ChIP_HELA_Human2.08102049
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06454251
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05363149
32XRN2_22483619_ChIP-Seq_HELA_Human2.05223857
33E2F1_21310950_ChIP-Seq_MCF-7_Human2.03093142
34DCP1A_22483619_ChIP-Seq_HELA_Human2.01034374
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99238670
36SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97699220
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.94225847
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.94141495
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86534166
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81932996
41TTF2_22483619_ChIP-Seq_HELA_Human1.77233898
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74629880
43* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69983761
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.67750481
45GABP_19822575_ChIP-Seq_HepG2_Human1.67749880
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66766621
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.62985000
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.59895975
49FUS_26573619_Chip-Seq_HEK293_Human1.59650655
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54135231
51SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51058375
52CIITA_25753668_ChIP-Seq_RAJI_Human1.49307845
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46226288
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45518296
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.41269857
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40353019
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38597157
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37123520
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36634903
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36167188
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33711746
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32974723
63KDM5A_27292631_Chip-Seq_BREAST_Human1.27257030
64VDR_22108803_ChIP-Seq_LS180_Human1.26166295
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.26088125
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25462059
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.22561257
68ZNF274_21170338_ChIP-Seq_K562_Hela1.21350009
69E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19294734
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16855041
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.16663164
72MYC_18940864_ChIP-ChIP_HL60_Human1.16323636
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.14263064
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13903686
75SPI1_23547873_ChIP-Seq_NB4_Human1.13503211
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10917544
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.10781565
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08291142
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04844190
80IGF1R_20145208_ChIP-Seq_DFB_Human1.02922451
81EGR1_19374776_ChIP-ChIP_THP-1_Human0.99410705
82HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97837175
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96914534
84POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96855249
85CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95372681
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.95098633
87TFEB_21752829_ChIP-Seq_HELA_Human0.92823442
88MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87330137
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86962141
90RBPJ_22232070_ChIP-Seq_NCS_Mouse0.85537382
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85092520
92P300_19829295_ChIP-Seq_ESCs_Human0.84652552
93SALL1_21062744_ChIP-ChIP_HESCs_Human0.84568553
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84311752
95STAT4_19710469_ChIP-ChIP_TH1__Mouse0.83325551
96TAF15_26573619_Chip-Seq_HEK293_Human0.82692151
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.82607199
98IRF8_21731497_ChIP-ChIP_J774_Mouse0.81490162
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80803417
100IRF1_19129219_ChIP-ChIP_H3396_Human0.80623086
101* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79262615
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.77871446
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.76991032
104MYC_22102868_ChIP-Seq_BL_Human0.76085835
105* KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.75897104
106NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.75672947
107EWS_26573619_Chip-Seq_HEK293_Human0.75281184
108* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71548759
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.70948611
110FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.70913271
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.69783954
112SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.69447657
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.68794139
114* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68730294
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68216386
116NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.67275595
117PCGF2_27294783_Chip-Seq_ESCs_Mouse0.67142223
118MYB_26560356_Chip-Seq_TH2_Human0.66177345
119MYB_21317192_ChIP-Seq_ERMYB_Mouse0.65200597
120FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.64478555
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.63694560
122TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.63391923
123EZH2_27294783_Chip-Seq_NPCs_Mouse0.63348266
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.62580750
125POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.62486732

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.99342806
2MP0010094_abnormal_chromosome_stability4.84853702
3MP0008057_abnormal_DNA_replication4.24753130
4MP0003111_abnormal_nucleus_morphology4.21215075
5MP0003077_abnormal_cell_cycle4.05107383
6MP0004957_abnormal_blastocyst_morpholog3.83343589
7MP0008058_abnormal_DNA_repair3.57176299
8MP0008007_abnormal_cellular_replicative2.94412476
9MP0002396_abnormal_hematopoietic_system2.81616454
10MP0008932_abnormal_embryonic_tissue2.63980862
11MP0008877_abnormal_DNA_methylation2.63488476
12MP0003786_premature_aging2.05854317
13MP0006072_abnormal_retinal_apoptosis2.05503012
14MP0003718_maternal_effect1.89047103
15MP0003763_abnormal_thymus_physiology1.88518213
16MP0010030_abnormal_orbit_morphology1.85202688
17MP0003941_abnormal_skin_development1.81306398
18MP0003806_abnormal_nucleotide_metabolis1.79948598
19MP0008789_abnormal_olfactory_epithelium1.79529740
20MP0003123_paternal_imprinting1.78398923
21MP0000350_abnormal_cell_proliferation1.77965521
22MP0000490_abnormal_crypts_of1.71459706
23MP0009333_abnormal_splenocyte_physiolog1.67270683
24MP0001730_embryonic_growth_arrest1.63216872
25MP0004808_abnormal_hematopoietic_stem1.60707455
26MP0002398_abnormal_bone_marrow1.51829574
27MP0006292_abnormal_olfactory_placode1.48806522
28MP0003121_genomic_imprinting1.42979459
29MP0000313_abnormal_cell_death1.40989726
30MP0002210_abnormal_sex_determination1.40980705
31MP0002019_abnormal_tumor_incidence1.38646241
32MP0001835_abnormal_antigen_presentation1.36911483
33MP0009697_abnormal_copulation1.36796284
34MP0005671_abnormal_response_to1.35280984
35MP0010307_abnormal_tumor_latency1.34878970
36MP0000703_abnormal_thymus_morphology1.31986692
37MP0005394_taste/olfaction_phenotype1.31549249
38MP0005499_abnormal_olfactory_system1.31549249
39MP0002234_abnormal_pharynx_morphology1.31441037
40MP0002095_abnormal_skin_pigmentation1.29968952
41MP0003136_yellow_coat_color1.27545698
42MP0001929_abnormal_gametogenesis1.27070568
43MP0002722_abnormal_immune_system1.26876535
44MP0000689_abnormal_spleen_morphology1.25688815
45MP0000647_abnormal_sebaceous_gland1.22138089
46MP0003315_abnormal_perineum_morphology1.21023107
47MP0004147_increased_porphyrin_level1.19860423
48MP0002102_abnormal_ear_morphology1.18440517
49MP0001697_abnormal_embryo_size1.18197993
50MP0002429_abnormal_blood_cell1.15799009
51MP0000716_abnormal_immune_system1.15704568
52MP0001853_heart_inflammation1.15668985
53MP0001145_abnormal_male_reproductive1.15121749
54MP0002233_abnormal_nose_morphology1.14138685
55MP0001800_abnormal_humoral_immune1.13505083
56MP0005397_hematopoietic_system_phenotyp1.12201616
57MP0001545_abnormal_hematopoietic_system1.12201616
58MP0000653_abnormal_sex_gland1.12045980
59MP0001986_abnormal_taste_sensitivity1.11349240
60MP0005075_abnormal_melanosome_morpholog1.11251203
61MP0001672_abnormal_embryogenesis/_devel1.09755444
62MP0005380_embryogenesis_phenotype1.09755444
63MP0001293_anophthalmia1.09480523
64MP0002420_abnormal_adaptive_immunity1.09459575
65MP0001286_abnormal_eye_development1.08109148
66MP0002080_prenatal_lethality1.07923032
67MP0002938_white_spotting1.07772095
68MP0001819_abnormal_immune_cell1.06873941
69MP0005253_abnormal_eye_physiology1.06584479
70MP0002132_abnormal_respiratory_system1.05796672
71MP0001119_abnormal_female_reproductive1.04030056
72MP0002697_abnormal_eye_size1.03764015
73MP0009379_abnormal_foot_pigmentation1.03598142
74MP0002452_abnormal_antigen_presenting1.02184796
75MP0002085_abnormal_embryonic_tissue1.02161005
76MP0006035_abnormal_mitochondrial_morpho0.99341154
77MP0001529_abnormal_vocalization0.99168825
78MP0002723_abnormal_immune_serum0.97026933
79MP0005408_hypopigmentation0.96642419
80MP0006054_spinal_hemorrhage0.96611253
81MP0000372_irregular_coat_pigmentation0.94749029
82MP0002090_abnormal_vision0.94592435
83MP0009785_altered_susceptibility_to0.93616392
84MP0000631_abnormal_neuroendocrine_gland0.91914009
85MP0005391_vision/eye_phenotype0.91790079
86MP0003567_abnormal_fetal_cardiomyocyte0.90683365
87MP0003984_embryonic_growth_retardation0.90002139
88MP0009672_abnormal_birth_weight0.89784987
89MP0002111_abnormal_tail_morphology0.89097614
90MP0003186_abnormal_redox_activity0.89088273
91MP0000358_abnormal_cell_content/0.88201455
92MP0005174_abnormal_tail_pigmentation0.87772712
93MP0005171_absent_coat_pigmentation0.87123481
94MP0002160_abnormal_reproductive_system0.86530705
95MP0002163_abnormal_gland_morphology0.86329514
96MP0000049_abnormal_middle_ear0.85809052
97MP0005248_abnormal_Harderian_gland0.85492986
98MP0001764_abnormal_homeostasis0.84959462
99MP0002088_abnormal_embryonic_growth/wei0.84927068
100MP0006036_abnormal_mitochondrial_physio0.84703694
101MP0001324_abnormal_eye_pigmentation0.84700791
102MP0005389_reproductive_system_phenotype0.83826431
103MP0003755_abnormal_palate_morphology0.82905122
104MP0002751_abnormal_autonomic_nervous0.82065751
105MP0003787_abnormal_imprinting0.81905720
106MP0003119_abnormal_digestive_system0.81637069
107MP0005025_abnormal_response_to0.81510190
108MP0005000_abnormal_immune_tolerance0.80559428
109MP0001346_abnormal_lacrimal_gland0.80080661
110MP0003656_abnormal_erythrocyte_physiolo0.80032083
111MP0002405_respiratory_system_inflammati0.78769149
112MP0003937_abnormal_limbs/digits/tail_de0.78677369
113MP0000465_gastrointestinal_hemorrhage0.78604312
114MP0002092_abnormal_eye_morphology0.77545130
115MP0001177_atelectasis0.77452146
116MP0003221_abnormal_cardiomyocyte_apopto0.75752785
117MP0002086_abnormal_extraembryonic_tissu0.75701697
118MP0002148_abnormal_hypersensitivity_rea0.75223432
119MP0000427_abnormal_hair_cycle0.74913428
120MP0002084_abnormal_developmental_patter0.72829794
121MP0010352_gastrointestinal_tract_polyps0.72068724
122MP0000015_abnormal_ear_pigmentation0.69082594
123MP0004197_abnormal_fetal_growth/weight/0.68788189
124MP0000685_abnormal_immune_system0.68065302
125MP0005646_abnormal_pituitary_gland0.67508411
126MP0005395_other_phenotype0.67257651
127MP0004215_abnormal_myocardial_fiber0.65783913
128MP0009703_decreased_birth_body0.65311791
129MP0005551_abnormal_eye_electrophysiolog0.65060209
130MP0000383_abnormal_hair_follicle0.65000448
131MP0002419_abnormal_innate_immunity0.64539908
132MP0001485_abnormal_pinna_reflex0.64311951
133MP0000428_abnormal_craniofacial_morphol0.63997023
134MP0005187_abnormal_penis_morphology0.63964462
135MP0008995_early_reproductive_senescence0.63712579
136MP0005195_abnormal_posterior_eye0.63213198
137MP0000579_abnormal_nail_morphology0.62628492
138MP0003861_abnormal_nervous_system0.62472398
139MP0003698_abnormal_male_reproductive0.61804530
140MP0000566_synostosis0.61775072
141MP0005451_abnormal_body_composition0.61672059
142MP0003890_abnormal_embryonic-extraembry0.61579422
143MP0005464_abnormal_platelet_physiology0.61458418
144MP0010155_abnormal_intestine_physiology0.60789662
145MP0003943_abnormal_hepatobiliary_system0.60454314

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.95898836
2Chromsome breakage (HP:0040012)4.58209935
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.44026825
4Reticulocytopenia (HP:0001896)4.36775480
5Abnormal number of erythroid precursors (HP:0012131)3.77669019
6Abnormality of cells of the erythroid lineage (HP:0012130)3.74786628
7Abnormality of chromosome stability (HP:0003220)3.51523766
8Breast hypoplasia (HP:0003187)3.33211012
9Abnormality of the preputium (HP:0100587)3.26918219
10Aplastic anemia (HP:0001915)3.21901946
11Meckel diverticulum (HP:0002245)3.13955476
12Abnormality of the labia minora (HP:0012880)3.09177906
13Abnormality of the ileum (HP:0001549)3.02834253
14Duplicated collecting system (HP:0000081)2.97263234
15Oral leukoplakia (HP:0002745)2.97015640
16Aplasia/Hypoplasia of the uvula (HP:0010293)2.96406534
17Myelodysplasia (HP:0002863)2.93962604
18Abnormal lung lobation (HP:0002101)2.90478804
19Small intestinal stenosis (HP:0012848)2.88212854
20Duodenal stenosis (HP:0100867)2.88212854
21Premature graying of hair (HP:0002216)2.87293004
22Patellar aplasia (HP:0006443)2.77993951
23Bone marrow hypocellularity (HP:0005528)2.77633134
24Pallor (HP:0000980)2.71884730
25Abnormality of the renal collecting system (HP:0004742)2.69030558
26Abnormality of the heme biosynthetic pathway (HP:0010472)2.63523979
27Sloping forehead (HP:0000340)2.58117553
28Septo-optic dysplasia (HP:0100842)2.57396819
29Aplasia/Hypoplasia of the patella (HP:0006498)2.52873222
30Ectopic kidney (HP:0000086)2.52808927
31Macrocytic anemia (HP:0001972)2.52488367
32Aplasia/Hypoplasia of the sacrum (HP:0008517)2.52378754
33Cerebral hypomyelination (HP:0006808)2.46220985
34Medulloblastoma (HP:0002885)2.43895691
35Pancytopenia (HP:0001876)2.43546366
36Thrombocytosis (HP:0001894)2.40123843
37Acute necrotizing encephalopathy (HP:0006965)2.39345238
38Rough bone trabeculation (HP:0100670)2.39170939
39Colon cancer (HP:0003003)2.38195664
40Lymphoma (HP:0002665)2.36618225
41IgM deficiency (HP:0002850)2.35391022
42Acute encephalopathy (HP:0006846)2.33255735
43Hypoplasia of the capital femoral epiphysis (HP:0003090)2.30016854
44Cleft eyelid (HP:0000625)2.28947491
45Hyperglycinemia (HP:0002154)2.28575093
46Abnormality of methionine metabolism (HP:0010901)2.28246895
47Type I transferrin isoform profile (HP:0003642)2.28006590
483-Methylglutaconic aciduria (HP:0003535)2.27325267
49Abnormality of serum amino acid levels (HP:0003112)2.25325210
50Clubbing of toes (HP:0100760)2.23845423
51Abnormality of the duodenum (HP:0002246)2.23312900
52Hypoplastic pelvis (HP:0008839)2.22368025
53Lipid accumulation in hepatocytes (HP:0006561)2.21559866
54Increased serum pyruvate (HP:0003542)2.19094019
55Abnormality of glycolysis (HP:0004366)2.19094019
56Supernumerary spleens (HP:0009799)2.18429014
57Intestinal atresia (HP:0011100)2.18176234
58Nephroblastoma (Wilms tumor) (HP:0002667)2.17776645
5911 pairs of ribs (HP:0000878)2.16284808
60Abnormality of B cell number (HP:0010975)2.15841062
61B lymphocytopenia (HP:0010976)2.15841062
62Increased CSF lactate (HP:0002490)2.15699232
63Absent thumb (HP:0009777)2.14436485
64Increased nuchal translucency (HP:0010880)2.14095553
65Abnormal mitochondria in muscle tissue (HP:0008316)2.12519793
66Volvulus (HP:0002580)2.12010377
67IgG deficiency (HP:0004315)2.11902564
68Mitochondrial inheritance (HP:0001427)2.11394816
69Triphalangeal thumb (HP:0001199)2.10358164
70Asplenia (HP:0001746)2.09829345
71Cortical dysplasia (HP:0002539)2.09449153
72Abnormality of alanine metabolism (HP:0010916)2.08702030
73Hyperalaninemia (HP:0003348)2.08702030
74Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08702030
75Neoplasm of the colon (HP:0100273)2.07967741
76Impulsivity (HP:0100710)2.06228652
77Methylmalonic acidemia (HP:0002912)2.06019995
78Horseshoe kidney (HP:0000085)2.05417878
79Abnormal spermatogenesis (HP:0008669)2.05336467
80Increased hepatocellular lipid droplets (HP:0006565)2.04638985
81Absent septum pellucidum (HP:0001331)2.04598659
82Megaloblastic anemia (HP:0001889)2.04390533
83Degeneration of anterior horn cells (HP:0002398)2.04140593
84Abnormality of the anterior horn cell (HP:0006802)2.04140593
85Median cleft lip (HP:0000161)2.03935283
86Embryonal renal neoplasm (HP:0011794)2.03355079
87Carpal bone hypoplasia (HP:0001498)2.03138049
88Cellular immunodeficiency (HP:0005374)2.02913207
89Selective tooth agenesis (HP:0001592)1.98858228
90Progressive macrocephaly (HP:0004481)1.97035503
91Pulmonary fibrosis (HP:0002206)1.94499159
92Exertional dyspnea (HP:0002875)1.93664371
93Absent radius (HP:0003974)1.93139451
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.92458217
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.92458217
96Aplasia/Hypoplasia of the spleen (HP:0010451)1.90964650
97Gastrointestinal atresia (HP:0002589)1.90272980
98Squamous cell carcinoma (HP:0002860)1.89914792
99Muscle fiber atrophy (HP:0100295)1.88568440
100Glioma (HP:0009733)1.88053096
101Abnormality of the carotid arteries (HP:0005344)1.87929544
102Abnormality of DNA repair (HP:0003254)1.87489938
103Increased serum lactate (HP:0002151)1.86813140
104Abnormality of serine family amino acid metabolism (HP:0010894)1.86727407
105Abnormality of glycine metabolism (HP:0010895)1.86727407
106Abnormal trabecular bone morphology (HP:0100671)1.86555536
107Arteriovenous malformation (HP:0100026)1.85469662
108Cerebral edema (HP:0002181)1.84979785
109Postnatal microcephaly (HP:0005484)1.84932944
110Abnormality of the septum pellucidum (HP:0007375)1.84354715
111Abnormal umbilical cord blood vessels (HP:0011403)1.84264294
112Single umbilical artery (HP:0001195)1.84264294
113Abnormality of the fetal cardiovascular system (HP:0010948)1.84264294
114Irregular epiphyses (HP:0010582)1.84207640
115Microretrognathia (HP:0000308)1.83644729
116Microvesicular hepatic steatosis (HP:0001414)1.83348229
117Hypopigmented skin patches (HP:0001053)1.82555852
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82171943
119Absent epiphyses (HP:0010577)1.82171943
120Abnormal number of incisors (HP:0011064)1.81492505
121Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81375221
122Rhabdomyosarcoma (HP:0002859)1.81268051
123Ependymoma (HP:0002888)1.80278419
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80225702
125Ureteral duplication (HP:0000073)1.80150582
126Type 2 muscle fiber atrophy (HP:0003554)1.79914495
127Hepatocellular necrosis (HP:0001404)1.79887756
128T lymphocytopenia (HP:0005403)1.78531162
129Short thumb (HP:0009778)1.78216040
130Oligodactyly (hands) (HP:0001180)1.77518412
131Acute myeloid leukemia (HP:0004808)1.77414426
132Tracheoesophageal fistula (HP:0002575)1.77314639
133Preaxial hand polydactyly (HP:0001177)1.76982519
134Agnosia (HP:0010524)1.76529438
135Oligodactyly (HP:0012165)1.76077331
136Esophageal atresia (HP:0002032)1.75361038
137Abnormality of T cells (HP:0002843)1.75194913
138Absent forearm bone (HP:0003953)1.74869426
139Aplasia involving forearm bones (HP:0009822)1.74869426
140Atresia of the external auditory canal (HP:0000413)1.74510066
141Secondary amenorrhea (HP:0000869)1.74504371
142True hermaphroditism (HP:0010459)1.74183606
143Astigmatism (HP:0000483)1.74160118
144Petechiae (HP:0000967)1.72137171
145Cafe-au-lait spot (HP:0000957)1.71746355
146Ovarian neoplasm (HP:0100615)1.70879756
147Bifid tongue (HP:0010297)1.70167304
148Neoplasm of the adrenal gland (HP:0100631)1.69905454
149Abnormal auditory evoked potentials (HP:0006958)1.69217050
150Choanal atresia (HP:0000453)1.69012606
151Pancreatic fibrosis (HP:0100732)1.67811981
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.67408616
153Renal Fanconi syndrome (HP:0001994)1.66681722
154Hemivertebrae (HP:0002937)1.65085911

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.52267034
2CDC73.94374081
3WEE13.81365238
4EIF2AK13.18642551
5SRPK12.81072833
6VRK22.70708736
7PLK42.68769290
8STK162.61391297
9BRSK22.55403219
10VRK12.38405113
11ACVR1B2.36952174
12NEK22.36893361
13MKNK12.25475320
14NME22.13310561
15TTK2.08383087
16TLK12.01551923
17PLK11.95349190
18MKNK21.85049220
19TAF11.79845343
20AURKB1.74154608
21TRIM281.73531173
22PNCK1.69480080
23CDK81.66344994
24CCNB11.64076543
25EIF2AK31.62764214
26BRSK11.59282467
27ATR1.55407022
28PBK1.55101474
29TXK1.51715269
30STK101.51705153
31PLK31.47498355
32CHEK21.47216412
33ZAK1.44413133
34CDK71.39844364
35DYRK31.38411759
36WNK31.33349129
37MAP4K21.30981913
38STK41.28446567
39MAP4K11.26492637
40PLK21.25654440
41TSSK61.24246017
42TEC1.19488779
43MST41.19374302
44RPS6KA41.18101131
45LATS11.17603909
46IRAK41.14939760
47TESK21.04418038
48ERBB31.03672875
49MELK1.02952885
50PASK1.02869054
51EIF2AK21.02587174
52CHEK11.02413812
53AURKA1.01345962
54BTK0.99101111
55MAP3K80.97388501
56CDK40.93210666
57NME10.92617184
58RPS6KB20.92526654
59STK390.90949520
60PIM10.89366270
61CLK10.89322159
62RPS6KA50.81187067
63BRAF0.80125580
64ATM0.79248547
65KIT0.76362180
66INSRR0.75998443
67MAP3K60.75670687
68TGFBR10.72581631
69DYRK20.71589617
70STK38L0.70707246
71CSNK2A10.68634001
72BMPR1B0.66980947
73MET0.66181949
74NUAK10.64972941
75BRD40.64533568
76CDK20.63028442
77NEK10.61396102
78CDK10.59948443
79YES10.59164616
80FLT30.58495586
81PIM20.57105074
82TNIK0.56573586
83CSNK1G30.56423097
84CSNK2A20.54808650
85OXSR10.53566273
86CDK90.50052347
87LYN0.49974380
88CDK30.49407018
89MARK30.48232038
90ERBB40.47987752
91TRPM70.47692323
92LRRK20.46128715
93CSNK1G20.45829936
94KDR0.45724758
95BCR0.44605129
96CSF1R0.44350612
97CDK190.41923875
98PAK40.41433552
99GRK10.40547807
100IRAK30.40538637
101LIMK10.40324471
102STK30.40016291
103FGFR10.39294361
104IKBKB0.38904572
105WNK40.37560838
106LCK0.37291881
107CSNK1G10.37235368
108IKBKE0.36620121
109NLK0.34693161
110CSNK1A1L0.34643194
111CDK120.34357142
112PAK10.33868999
113JAK30.33836035
114MAPK130.33794227
115MAPKAPK50.33090800
116ZAP700.32772302
117PDK20.32234127
118BCKDK0.32194437
119PRKDC0.30665118
120SCYL20.30573647
121ITK0.29137921
122CDK60.28955719
123SYK0.28905345
124MAP3K100.27891959
125MAP2K70.26931595
126ABL20.26643198
127UHMK10.26324928
128CSNK1E0.25605559
129CSNK1A10.25188387
130ADRBK20.25172018
131CDK180.21876225
132PRKD30.20583036
133CDK140.19546859
134CDK150.19089099
135MAP3K40.18666926
136FRK0.18476337
137CDK11A0.16506620

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.89073765
2Mismatch repair_Homo sapiens_hsa034304.01938102
3Homologous recombination_Homo sapiens_hsa034403.48740676
4Ribosome_Homo sapiens_hsa030103.41897831
5RNA polymerase_Homo sapiens_hsa030203.30082283
6Proteasome_Homo sapiens_hsa030503.09929550
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09677551
8Spliceosome_Homo sapiens_hsa030403.04225406
9Base excision repair_Homo sapiens_hsa034102.95454964
10Cell cycle_Homo sapiens_hsa041102.91335972
11Nucleotide excision repair_Homo sapiens_hsa034202.83698049
12Fanconi anemia pathway_Homo sapiens_hsa034602.60441096
13RNA transport_Homo sapiens_hsa030132.47264616
14Basal transcription factors_Homo sapiens_hsa030222.47140748
15Pyrimidine metabolism_Homo sapiens_hsa002402.41696138
16Non-homologous end-joining_Homo sapiens_hsa034502.38201521
17RNA degradation_Homo sapiens_hsa030181.91568706
18One carbon pool by folate_Homo sapiens_hsa006701.70902715
19Protein export_Homo sapiens_hsa030601.70241025
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64056946
21p53 signaling pathway_Homo sapiens_hsa041151.60178944
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.59826495
23Propanoate metabolism_Homo sapiens_hsa006401.56279144
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54065145
25mRNA surveillance pathway_Homo sapiens_hsa030151.43881896
26Systemic lupus erythematosus_Homo sapiens_hsa053221.42655517
27Purine metabolism_Homo sapiens_hsa002301.40639435
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34669092
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27097034
30Pyruvate metabolism_Homo sapiens_hsa006201.25437046
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25231995
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25112112
33Primary immunodeficiency_Homo sapiens_hsa053401.19772334
34Epstein-Barr virus infection_Homo sapiens_hsa051691.17933507
35Vitamin B6 metabolism_Homo sapiens_hsa007501.15617363
36Herpes simplex infection_Homo sapiens_hsa051681.09661738
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06203559
38Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04815184
39Biosynthesis of amino acids_Homo sapiens_hsa012301.01489339
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01395076
41Viral carcinogenesis_Homo sapiens_hsa052030.92097399
42Carbon metabolism_Homo sapiens_hsa012000.88670690
43Oocyte meiosis_Homo sapiens_hsa041140.86070604
44Huntingtons disease_Homo sapiens_hsa050160.82332866
45Antigen processing and presentation_Homo sapiens_hsa046120.82272965
46Folate biosynthesis_Homo sapiens_hsa007900.80914814
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79824114
48Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78353918
49Hematopoietic cell lineage_Homo sapiens_hsa046400.75117801
50Measles_Homo sapiens_hsa051620.74540501
51Parkinsons disease_Homo sapiens_hsa050120.73578024
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72079611
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.70782869
54Intestinal immune network for IgA production_Homo sapiens_hsa046720.68828434
55Oxidative phosphorylation_Homo sapiens_hsa001900.68076571
56Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67245246
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66515342
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64137400
59Butanoate metabolism_Homo sapiens_hsa006500.63806153
60HTLV-I infection_Homo sapiens_hsa051660.63196294
61Steroid biosynthesis_Homo sapiens_hsa001000.60469659
62Hedgehog signaling pathway_Homo sapiens_hsa043400.59420143
63Autoimmune thyroid disease_Homo sapiens_hsa053200.57661447
64Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56814620
65Allograft rejection_Homo sapiens_hsa053300.56161760
66Alcoholism_Homo sapiens_hsa050340.55713538
67Sulfur relay system_Homo sapiens_hsa041220.55562703
68Glutathione metabolism_Homo sapiens_hsa004800.53665959
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53293734
70Asthma_Homo sapiens_hsa053100.52166337
71Arachidonic acid metabolism_Homo sapiens_hsa005900.50172357
72Small cell lung cancer_Homo sapiens_hsa052220.50072976
73Hepatitis B_Homo sapiens_hsa051610.49703980
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49661560
75Sulfur metabolism_Homo sapiens_hsa009200.49353858
76RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48951241
77Legionellosis_Homo sapiens_hsa051340.48782842
78Pentose phosphate pathway_Homo sapiens_hsa000300.48668567
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47843952
80MicroRNAs in cancer_Homo sapiens_hsa052060.46057213
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45414796
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44887867
83Vitamin digestion and absorption_Homo sapiens_hsa049770.43697811
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43629986
85Peroxisome_Homo sapiens_hsa041460.42471429
86Hippo signaling pathway_Homo sapiens_hsa043900.41402024
87Shigellosis_Homo sapiens_hsa051310.40322508
88N-Glycan biosynthesis_Homo sapiens_hsa005100.38039978
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37538030
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.37108510
91Fatty acid metabolism_Homo sapiens_hsa012120.37103254
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36960142
93Apoptosis_Homo sapiens_hsa042100.36835804
94Cardiac muscle contraction_Homo sapiens_hsa042600.35993878
95Regulation of autophagy_Homo sapiens_hsa041400.34689462
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33269140
97Wnt signaling pathway_Homo sapiens_hsa043100.32685704
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.32544958
99Alzheimers disease_Homo sapiens_hsa050100.30164362
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.30153619
101Graft-versus-host disease_Homo sapiens_hsa053320.29651985
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28981970
103Influenza A_Homo sapiens_hsa051640.28842050
104Thyroid cancer_Homo sapiens_hsa052160.28556524
105Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.27666727
106Arginine biosynthesis_Homo sapiens_hsa002200.27299458
107Leishmaniasis_Homo sapiens_hsa051400.26472457
108Metabolic pathways_Homo sapiens_hsa011000.26296566
109Malaria_Homo sapiens_hsa051440.26163560
110Arginine and proline metabolism_Homo sapiens_hsa003300.25951513
111TGF-beta signaling pathway_Homo sapiens_hsa043500.25733148
112Ether lipid metabolism_Homo sapiens_hsa005650.25127399
113Colorectal cancer_Homo sapiens_hsa052100.24418123
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23694139
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.23543109
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.23332036
117Linoleic acid metabolism_Homo sapiens_hsa005910.23171686
118Fatty acid degradation_Homo sapiens_hsa000710.22467848
119Phototransduction_Homo sapiens_hsa047440.22257249
120Chemical carcinogenesis_Homo sapiens_hsa052040.22081861
121Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22002254
122Caffeine metabolism_Homo sapiens_hsa002320.21350111
123Sphingolipid metabolism_Homo sapiens_hsa006000.19895038
124T cell receptor signaling pathway_Homo sapiens_hsa046600.19525752
125Selenocompound metabolism_Homo sapiens_hsa004500.18496438
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.18287028
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.18265452
128Nitrogen metabolism_Homo sapiens_hsa009100.18119507
129Retinol metabolism_Homo sapiens_hsa008300.17946382
130Pathways in cancer_Homo sapiens_hsa052000.15359594
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.15317140
132B cell receptor signaling pathway_Homo sapiens_hsa046620.15151738
133Notch signaling pathway_Homo sapiens_hsa043300.14586799
134Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14477984
135Basal cell carcinoma_Homo sapiens_hsa052170.13813961
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.13629444
137beta-Alanine metabolism_Homo sapiens_hsa004100.13450519
138Tryptophan metabolism_Homo sapiens_hsa003800.12657642
139Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.12398984
140Viral myocarditis_Homo sapiens_hsa054160.10676191
141Fatty acid elongation_Homo sapiens_hsa000620.10439699
142Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10356897
143Other glycan degradation_Homo sapiens_hsa005110.10238772
144Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.09709657

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