CENPN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.23094665
2attachment of spindle microtubules to kinetochore (GO:0008608)5.59137501
3protein localization to kinetochore (GO:0034501)5.56499835
4metaphase plate congression (GO:0051310)5.33953434
5protein localization to chromosome, centromeric region (GO:0071459)5.24976841
6mitotic sister chromatid segregation (GO:0000070)5.00361573
7mitotic chromosome condensation (GO:0007076)4.99141815
8regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.97186202
9establishment of chromosome localization (GO:0051303)4.89737055
10meiotic chromosome segregation (GO:0045132)4.67663677
11DNA replication checkpoint (GO:0000076)4.65788013
12regulation of spindle organization (GO:0090224)4.60170326
13establishment of integrated proviral latency (GO:0075713)4.58036478
14kinetochore organization (GO:0051383)4.53537758
15sister chromatid segregation (GO:0000819)4.41230734
16mitotic nuclear envelope disassembly (GO:0007077)4.39670524
17DNA replication initiation (GO:0006270)4.33973641
18proteasome assembly (GO:0043248)4.33938775
19* CENP-A containing nucleosome assembly (GO:0034080)4.29679833
20* chromatin remodeling at centromere (GO:0031055)4.26778081
21kinetochore assembly (GO:0051382)4.19472007
22DNA strand elongation involved in DNA replication (GO:0006271)4.18615174
23DNA replication-dependent nucleosome assembly (GO:0006335)4.17761936
24DNA replication-dependent nucleosome organization (GO:0034723)4.17761936
25positive regulation of chromosome segregation (GO:0051984)4.15769027
26* DNA replication-independent nucleosome assembly (GO:0006336)4.11530864
27* DNA replication-independent nucleosome organization (GO:0034724)4.11530864
28protein localization to chromosome (GO:0034502)4.08791373
29nuclear envelope disassembly (GO:0051081)4.08634328
30membrane disassembly (GO:0030397)4.08634328
31regulation of chromosome segregation (GO:0051983)4.05608618
32spindle checkpoint (GO:0031577)4.05115722
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.03807412
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.02135546
35piRNA metabolic process (GO:0034587)4.01232889
36DNA strand elongation (GO:0022616)3.99156028
37DNA ligation (GO:0006266)3.96513593
38telomere maintenance via semi-conservative replication (GO:0032201)3.94539544
39* histone exchange (GO:0043486)3.94015887
40regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.93051528
41regulation of mitotic spindle organization (GO:0060236)3.90369866
42telomere maintenance via recombination (GO:0000722)3.85051046
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.84979641
44* chromosome segregation (GO:0007059)3.84958501
45maturation of 5.8S rRNA (GO:0000460)3.82651656
46protein K6-linked ubiquitination (GO:0085020)3.82632114
47regulation of sister chromatid cohesion (GO:0007063)3.75673406
48negative regulation of chromosome segregation (GO:0051985)3.75352876
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.74866021
50positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.72637747
51positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.72637747
52positive regulation of mitotic sister chromatid separation (GO:1901970)3.72637747
53regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.72590517
54mitotic recombination (GO:0006312)3.72374490
55negative regulation of sister chromatid segregation (GO:0033046)3.71252262
56negative regulation of mitotic sister chromatid separation (GO:2000816)3.71252262
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.71252262
58negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.71252262
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.70627549
60regulation of mitotic metaphase/anaphase transition (GO:0030071)3.69764248
61negative regulation of ligase activity (GO:0051352)3.68494941
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.68494941
63mitotic spindle checkpoint (GO:0071174)3.65126963
64establishment of protein localization to mitochondrial membrane (GO:0090151)3.64352060
65regulation of double-strand break repair via homologous recombination (GO:0010569)3.63376601
66spindle assembly checkpoint (GO:0071173)3.63234650
67regulation of exit from mitosis (GO:0007096)3.60575864
68meiotic cell cycle (GO:0051321)3.60048599
69establishment of viral latency (GO:0019043)3.59963241
70mitotic spindle assembly checkpoint (GO:0007094)3.58945593
71chaperone-mediated protein transport (GO:0072321)3.57584547
72nuclear pore organization (GO:0006999)3.55370141
73regulation of mitotic sister chromatid separation (GO:0010965)3.54577129
74regulation of mitotic sister chromatid segregation (GO:0033047)3.54577129
75regulation of sister chromatid segregation (GO:0033045)3.54577129
76microtubule depolymerization (GO:0007019)3.53104229
77ribosomal small subunit assembly (GO:0000028)3.52779273
78DNA unwinding involved in DNA replication (GO:0006268)3.51568403
79mitotic sister chromatid cohesion (GO:0007064)3.50201969
80nuclear pore complex assembly (GO:0051292)3.50105472
81regulation of centrosome cycle (GO:0046605)3.44820110
82IMP biosynthetic process (GO:0006188)3.42274841
83chromosome condensation (GO:0030261)3.39633396
84ribosomal large subunit biogenesis (GO:0042273)3.37992483
85DNA topological change (GO:0006265)3.36061601
86male meiosis (GO:0007140)3.34526118
87telomere maintenance via telomere lengthening (GO:0010833)3.33866222
88* chromatin assembly or disassembly (GO:0006333)3.32227525
89ATP synthesis coupled proton transport (GO:0015986)3.31986802
90energy coupled proton transport, down electrochemical gradient (GO:0015985)3.31986802
91rRNA modification (GO:0000154)3.31599205
92maturation of SSU-rRNA (GO:0030490)3.29554336
93nucleobase-containing small molecule interconversion (GO:0015949)3.28656076
94ribosomal small subunit biogenesis (GO:0042274)3.28071213
95nucleotide-excision repair, DNA gap filling (GO:0006297)3.25366260
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.24761081
97nucleobase biosynthetic process (GO:0046112)3.23069320
98nuclear envelope organization (GO:0006998)3.21882664
99mismatch repair (GO:0006298)3.19470709
100regulation of centriole replication (GO:0046599)3.19454780
101purine nucleobase biosynthetic process (GO:0009113)3.17593380
102cell cycle G1/S phase transition (GO:0044843)3.16922163
103G1/S transition of mitotic cell cycle (GO:0000082)3.16922163
104L-serine metabolic process (GO:0006563)3.15083597
105regulation of mitochondrial translation (GO:0070129)3.14945423
106spliceosomal snRNP assembly (GO:0000387)3.14808478
107non-recombinational repair (GO:0000726)3.12867088
108double-strand break repair via nonhomologous end joining (GO:0006303)3.12867088
109replication fork processing (GO:0031297)3.12302311
110regulation of spindle checkpoint (GO:0090231)3.11566072
111regulation of ubiquitin-protein transferase activity (GO:0051438)3.11329759
112* mitotic cell cycle (GO:0000278)3.11074253
113positive regulation of ligase activity (GO:0051351)3.10735653
114DNA packaging (GO:0006323)3.10630199
115synaptonemal complex assembly (GO:0007130)3.10191244
116maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.09495201
117transcription-coupled nucleotide-excision repair (GO:0006283)3.09142694
118meiotic cell cycle process (GO:1903046)3.08194863
119formation of translation preinitiation complex (GO:0001731)3.05904769
120ribosome assembly (GO:0042255)3.05706928
121negative regulation of mitosis (GO:0045839)3.05336580
122anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05039852
123negative regulation of DNA-templated transcription, elongation (GO:0032785)3.04198026
124negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.04198026
125signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03174775
126signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03174775
127monoubiquitinated protein deubiquitination (GO:0035520)3.02052482
128DNA damage response, signal transduction resulting in transcription (GO:0042772)3.01782883
129meiotic nuclear division (GO:0007126)3.00061587
130folic acid-containing compound biosynthetic process (GO:0009396)2.99855310
131* ATP-dependent chromatin remodeling (GO:0043044)2.96982691
132DNA synthesis involved in DNA repair (GO:0000731)2.95245476
133oocyte maturation (GO:0001556)2.95005154
134negative regulation of meiosis (GO:0045835)2.93093670
135meiosis I (GO:0007127)2.92532636
136regulation of mitotic spindle checkpoint (GO:1903504)2.91985185
137regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.91985185

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.51333070
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.30716005
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.47530580
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.34289509
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.68439295
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.58139477
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.09697306
8* AR_21909140_ChIP-Seq_LNCAP_Human2.99251409
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.70501061
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.62817140
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.58451791
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.50016349
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.49797994
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47809813
15* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45033775
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42015111
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.37983359
18MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.36508819
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.29369586
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.22227409
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20616936
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.08770079
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03831505
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.03133187
25MYCN_18555785_ChIP-Seq_MESCs_Mouse2.02185200
26VDR_23849224_ChIP-Seq_CD4+_Human1.99683458
27XRN2_22483619_ChIP-Seq_HELA_Human1.97215812
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.88181588
29DCP1A_22483619_ChIP-Seq_HELA_Human1.84748054
30PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81984398
31NANOG_18555785_ChIP-Seq_MESCs_Mouse1.80627200
32GABP_19822575_ChIP-Seq_HepG2_Human1.79774651
33E2F1_18555785_ChIP-Seq_MESCs_Mouse1.75941745
34* FOXP3_21729870_ChIP-Seq_TREG_Human1.66831858
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57349397
36TTF2_22483619_ChIP-Seq_HELA_Human1.55246362
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53550168
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52413339
39KDM5A_27292631_Chip-Seq_BREAST_Human1.48217593
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.47955245
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.44739706
42* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42861250
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39627611
44* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.36309052
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35984880
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35554194
47CIITA_25753668_ChIP-Seq_RAJI_Human1.35341708
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35169193
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33304651
50* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.31232993
51ELK1_19687146_ChIP-ChIP_HELA_Human1.31194889
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29789525
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.28175824
54RBPJ_22232070_ChIP-Seq_NCS_Mouse1.25991139
55KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25636769
56SRF_21415370_ChIP-Seq_HL-1_Mouse1.21698707
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18311150
58MYC_22102868_ChIP-Seq_BL_Human1.17351357
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.15998256
60MYC_18940864_ChIP-ChIP_HL60_Human1.15320660
61CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.15062492
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12241286
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11974063
64NANOG_16153702_ChIP-ChIP_HESCs_Human1.11203095
65ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11036774
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10302384
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06787304
68SOX17_20123909_ChIP-Seq_XEN_Mouse1.06362250
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.04259580
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.03907612
71NANOG_21062744_ChIP-ChIP_HESCs_Human1.03588061
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.03442759
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01955816
74POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01479357
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99719776
76ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99123203
77ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98985884
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98256039
79SOX2_16153702_ChIP-ChIP_HESCs_Human0.97291196
80SOX2_18555785_ChIP-Seq_MESCs_Mouse0.95155365
81SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.95022637
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.92957693
83TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.92179552
84CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90660890
85ELK1_22589737_ChIP-Seq_MCF10A_Human0.88286060
86SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88098359
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.87551628
88FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87431737
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.86668432
90ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85668037
91* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85644890
92* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84974703
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.84777898
94POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82889748
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81660843
96ZNF263_19887448_ChIP-Seq_K562_Human0.80820030
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80558191
98PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80430100
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.80204418
100TFEB_21752829_ChIP-Seq_HELA_Human0.79893868
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.79526410
102PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77910400
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77778750
104TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.77216151
105EWS_26573619_Chip-Seq_HEK293_Human0.74372596
106TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.73974342
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73252127
108SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.72252963
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.72207379
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.71061602
111NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.71013518
112CHD1_26751641_Chip-Seq_LNCaP_Human0.70430373
113TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70147578
114SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69722779
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.67853204
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.66776626
117SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.66019771
118SPI1_23547873_ChIP-Seq_NB4_Human0.64310286
119* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.63425893
120KAP1_27257070_Chip-Seq_ESCs_Mouse0.62597892
121HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.62493946

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.95360460
2MP0010094_abnormal_chromosome_stability5.10190616
3MP0003111_abnormal_nucleus_morphology4.90301783
4MP0003077_abnormal_cell_cycle4.40508570
5MP0004957_abnormal_blastocyst_morpholog4.36414212
6MP0008057_abnormal_DNA_replication3.90177518
7MP0008877_abnormal_DNA_methylation3.53588824
8MP0003718_maternal_effect3.18056203
9MP0008058_abnormal_DNA_repair3.14022639
10MP0008007_abnormal_cellular_replicative2.90870288
11MP0008932_abnormal_embryonic_tissue2.75498979
12MP0003123_paternal_imprinting2.52686742
13MP0001730_embryonic_growth_arrest2.28547711
14MP0000350_abnormal_cell_proliferation2.22157939
15MP0002102_abnormal_ear_morphology2.20308560
16MP0001929_abnormal_gametogenesis2.17148594
17MP0002210_abnormal_sex_determination2.08417998
18MP0002653_abnormal_ependyma_morphology2.02801675
19MP0009379_abnormal_foot_pigmentation1.97980616
20MP0003786_premature_aging1.92717065
21MP0002938_white_spotting1.89093450
22MP0010307_abnormal_tumor_latency1.83823761
23MP0001697_abnormal_embryo_size1.79740019
24MP0000653_abnormal_sex_gland1.77035149
25MP0002396_abnormal_hematopoietic_system1.76068872
26MP0005380_embryogenesis_phenotype1.73541230
27MP0001672_abnormal_embryogenesis/_devel1.73541230
28MP0001145_abnormal_male_reproductive1.72502420
29MP0005451_abnormal_body_composition1.71265833
30MP0003646_muscle_fatigue1.64149935
31MP0002085_abnormal_embryonic_tissue1.63506030
32MP0001119_abnormal_female_reproductive1.61764065
33MP0003136_yellow_coat_color1.58255609
34MP0003121_genomic_imprinting1.49859269
35MP0006035_abnormal_mitochondrial_morpho1.47834311
36MP0003984_embryonic_growth_retardation1.46946976
37MP0000490_abnormal_crypts_of1.45520174
38MP0002019_abnormal_tumor_incidence1.45328722
39MP0002080_prenatal_lethality1.44995352
40MP0006292_abnormal_olfactory_placode1.44185695
41MP0002084_abnormal_developmental_patter1.43141699
42MP0002088_abnormal_embryonic_growth/wei1.41935937
43MP0000372_irregular_coat_pigmentation1.36280826
44MP0005410_abnormal_fertilization1.35471308
45MP0000313_abnormal_cell_death1.32775728
46MP0003698_abnormal_male_reproductive1.32641033
47MP0003315_abnormal_perineum_morphology1.29421822
48MP0003699_abnormal_female_reproductive1.29226741
49MP0006036_abnormal_mitochondrial_physio1.26735827
50MP0002086_abnormal_extraembryonic_tissu1.24899711
51MP0002697_abnormal_eye_size1.22352437
52MP0002161_abnormal_fertility/fecundity1.21027571
53MP0005395_other_phenotype1.19541240
54MP0003937_abnormal_limbs/digits/tail_de1.15233998
55MP0004808_abnormal_hematopoietic_stem1.15034970
56MP0010352_gastrointestinal_tract_polyps1.12556937
57MP0003890_abnormal_embryonic-extraembry1.07995501
58MP0001346_abnormal_lacrimal_gland1.06172493
59MP0005397_hematopoietic_system_phenotyp1.03027248
60MP0001545_abnormal_hematopoietic_system1.03027248
61MP0002160_abnormal_reproductive_system1.02649368
62MP0005076_abnormal_cell_differentiation1.02391361
63MP0005408_hypopigmentation1.01927974
64MP0005389_reproductive_system_phenotype0.96460006
65MP0006072_abnormal_retinal_apoptosis0.96226516
66MP0008789_abnormal_olfactory_epithelium0.94249343
67MP0004197_abnormal_fetal_growth/weight/0.94115478
68MP0010030_abnormal_orbit_morphology0.93386010
69MP0009333_abnormal_splenocyte_physiolog0.91523358
70MP0002233_abnormal_nose_morphology0.91314609
71MP0000537_abnormal_urethra_morphology0.87555348
72MP0003763_abnormal_thymus_physiology0.84820496
73MP0005621_abnormal_cell_physiology0.84159313
74MP0001915_intracranial_hemorrhage0.83415080
75MP0005171_absent_coat_pigmentation0.82355611
76MP0001881_abnormal_mammary_gland0.82296440
77MP0002234_abnormal_pharynx_morphology0.81195930
78MP0000703_abnormal_thymus_morphology0.81062273
79MP0005384_cellular_phenotype0.80268180
80MP0000647_abnormal_sebaceous_gland0.80090928
81MP0003787_abnormal_imprinting0.79164543
82MP0004264_abnormal_extraembryonic_tissu0.77897030
83MP0000579_abnormal_nail_morphology0.77854269
84MP0002398_abnormal_bone_marrow0.77329345
85MP0002092_abnormal_eye_morphology0.75244431
86MP0003567_abnormal_fetal_cardiomyocyte0.74108952
87MP0000627_abnormal_mammary_gland0.71903514
88MP0000689_abnormal_spleen_morphology0.70902703
89MP0005501_abnormal_skin_physiology0.70643534
90MP0001293_anophthalmia0.69398062
91MP0001919_abnormal_reproductive_system0.69185926
92MP0002877_abnormal_melanocyte_morpholog0.68260509
93MP0001727_abnormal_embryo_implantation0.67994650
94MP0002722_abnormal_immune_system0.67938872
95MP0000049_abnormal_middle_ear0.67629517
96MP0008995_early_reproductive_senescence0.67608691
97MP0000358_abnormal_cell_content/0.67367416
98MP0002249_abnormal_larynx_morphology0.67254855
99MP0004233_abnormal_muscle_weight0.67062287
100MP0009672_abnormal_birth_weight0.65482950
101MP0003950_abnormal_plasma_membrane0.64667106
102MP0000762_abnormal_tongue_morphology0.63059098
103MP0005391_vision/eye_phenotype0.61486265
104MP0000428_abnormal_craniofacial_morphol0.61061280
105MP0004147_increased_porphyrin_level0.61009366
106MP0005394_taste/olfaction_phenotype0.60951072
107MP0005499_abnormal_olfactory_system0.60951072
108MP0001764_abnormal_homeostasis0.60143353
109MP0003186_abnormal_redox_activity0.59387050
110MP0003705_abnormal_hypodermis_morpholog0.59250717
111MP0005248_abnormal_Harderian_gland0.58048654
112MP0002111_abnormal_tail_morphology0.57648564
113MP0003656_abnormal_erythrocyte_physiolo0.57408356
114MP0003119_abnormal_digestive_system0.56711116
115MP0008260_abnormal_autophagy0.56186373
116MP0001849_ear_inflammation0.55851530
117MP0000858_altered_metastatic_potential0.54491780
118MP0000432_abnormal_head_morphology0.54089110
119MP0002429_abnormal_blood_cell0.53943410
120MP0002163_abnormal_gland_morphology0.53901629
121MP0003221_abnormal_cardiomyocyte_apopto0.52423465
122MP0001286_abnormal_eye_development0.51171566
123MP0005023_abnormal_wound_healing0.51164561
124MP0003941_abnormal_skin_development0.48835887
125MP0003861_abnormal_nervous_system0.48556133
126MP0009703_decreased_birth_body0.47119744
127MP0003755_abnormal_palate_morphology0.46796736
128MP0009697_abnormal_copulation0.46323303
129MP0002932_abnormal_joint_morphology0.44087889
130MP0003936_abnormal_reproductive_system0.44082118
131MP0001529_abnormal_vocalization0.42994715
132MP0003806_abnormal_nucleotide_metabolis0.42361050
133MP0002114_abnormal_axial_skeleton0.42005398
134MP0000716_abnormal_immune_system0.40199841

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.03615384
2Chromsome breakage (HP:0040012)5.24496870
3Breast hypoplasia (HP:0003187)5.05748050
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.96528445
5Patellar aplasia (HP:0006443)4.38783456
6Male infertility (HP:0003251)4.13437966
7Aplasia/Hypoplasia of the patella (HP:0006498)4.08976831
8Abnormality of chromosome stability (HP:0003220)3.95094836
9Meckel diverticulum (HP:0002245)3.75612233
10Abnormality of the preputium (HP:0100587)3.64419688
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.63840150
12Acute necrotizing encephalopathy (HP:0006965)3.62869476
13Carpal bone hypoplasia (HP:0001498)3.62204623
14Abnormality of the ileum (HP:0001549)3.54691328
15Impulsivity (HP:0100710)3.51216595
16Increased hepatocellular lipid droplets (HP:0006565)3.42073615
17Acute encephalopathy (HP:0006846)3.40195569
18Abnormal mitochondria in muscle tissue (HP:0008316)3.34112259
19Duodenal stenosis (HP:0100867)3.31005823
20Small intestinal stenosis (HP:0012848)3.31005823
21Abnormality of the labia minora (HP:0012880)3.30774986
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.28521100
23Lipid accumulation in hepatocytes (HP:0006561)3.11415138
24Oral leukoplakia (HP:0002745)3.05116196
25Mitochondrial inheritance (HP:0001427)3.03809178
26Supernumerary spleens (HP:0009799)3.02234762
27Increased CSF lactate (HP:0002490)3.00734939
28Myelodysplasia (HP:0002863)2.98196028
29Ectopic kidney (HP:0000086)2.94491895
30Premature ovarian failure (HP:0008209)2.93488456
31Absent radius (HP:0003974)2.92354127
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.92042367
33Facial hemangioma (HP:0000329)2.88788702
34Sloping forehead (HP:0000340)2.87579250
35Medulloblastoma (HP:0002885)2.85439145
36Aplastic anemia (HP:0001915)2.84809805
37Macrocytic anemia (HP:0001972)2.84379781
38Abnormality of the anterior horn cell (HP:0006802)2.83969178
39Degeneration of anterior horn cells (HP:0002398)2.83969178
40Progressive macrocephaly (HP:0004481)2.81449118
41Secondary amenorrhea (HP:0000869)2.81334082
42Hepatocellular necrosis (HP:0001404)2.77292186
43Absent forearm bone (HP:0003953)2.72824284
44Aplasia involving forearm bones (HP:0009822)2.72824284
45Hypoplasia of the capital femoral epiphysis (HP:0003090)2.71309903
46Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.69592681
47Abnormal lung lobation (HP:0002101)2.65778501
48Cerebral edema (HP:0002181)2.65708144
49Abnormal spermatogenesis (HP:0008669)2.63913970
50Abnormality of the duodenum (HP:0002246)2.62336136
51Rhabdomyosarcoma (HP:0002859)2.62235567
52Cerebral hypomyelination (HP:0006808)2.59197867
53Selective tooth agenesis (HP:0001592)2.58679885
54Increased serum pyruvate (HP:0003542)2.56917691
55Bone marrow hypocellularity (HP:0005528)2.56381344
56Colon cancer (HP:0003003)2.53108534
57Abnormality of glycolysis (HP:0004366)2.52417230
58Aplasia/Hypoplasia of the sternum (HP:0006714)2.52210808
59Renal Fanconi syndrome (HP:0001994)2.50392666
60Nephroblastoma (Wilms tumor) (HP:0002667)2.46719133
61Rough bone trabeculation (HP:0100670)2.44533074
62Hepatic necrosis (HP:0002605)2.44097070
63Abnormality of the carotid arteries (HP:0005344)2.41359299
64Reticulocytopenia (HP:0001896)2.40470015
65Microvesicular hepatic steatosis (HP:0001414)2.37579822
66Short thumb (HP:0009778)2.37147381
67Clubbing of toes (HP:0100760)2.36592107
68Absent thumb (HP:0009777)2.32834370
69Cafe-au-lait spot (HP:0000957)2.32265607
70Breast aplasia (HP:0100783)2.31917668
71Shawl scrotum (HP:0000049)2.30992575
72Horseshoe kidney (HP:0000085)2.29805139
73Aplasia/Hypoplasia of the breasts (HP:0010311)2.29650658
74Abnormality of methionine metabolism (HP:0010901)2.28472752
75Embryonal renal neoplasm (HP:0011794)2.27360856
76Increased serum lactate (HP:0002151)2.25522958
77Multiple enchondromatosis (HP:0005701)2.25377489
78Ependymoma (HP:0002888)2.20719910
79Capillary hemangiomas (HP:0005306)2.18695377
80Microretrognathia (HP:0000308)2.17740316
81Agnosia (HP:0010524)2.15577460
82Flat capital femoral epiphysis (HP:0003370)2.15498960
83Pallor (HP:0000980)2.14369399
84Pancytopenia (HP:0001876)2.13447629
85Triphalangeal thumb (HP:0001199)2.13099947
86Type I transferrin isoform profile (HP:0003642)2.12478904
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.11179842
88Decreased activity of mitochondrial respiratory chain (HP:0008972)2.11179842
89Cleft eyelid (HP:0000625)2.09870746
90Papillary thyroid carcinoma (HP:0002895)2.09118855
91Tracheoesophageal fistula (HP:0002575)2.08951870
92Acute myeloid leukemia (HP:0004808)2.08787379
93Abnormal number of incisors (HP:0011064)2.08157928
94Hypoplastic pelvis (HP:0008839)2.06034137
95Oligodactyly (HP:0012165)2.04347687
96Chronic bronchitis (HP:0004469)2.03857413
97Adrenal hypoplasia (HP:0000835)2.02937534
98Increased nuchal translucency (HP:0010880)2.02601324
99Lactic acidosis (HP:0003128)2.02333416
100Atresia of the external auditory canal (HP:0000413)2.01845734
101Absent epiphyses (HP:0010577)2.01826606
102Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.01826606
103Leukodystrophy (HP:0002415)1.99687413
104Volvulus (HP:0002580)1.98573425
105Increased intramyocellular lipid droplets (HP:0012240)1.98475088
106Squamous cell carcinoma (HP:0002860)1.98192018
107Irregular epiphyses (HP:0010582)1.97930256
108Respiratory difficulties (HP:0002880)1.97408687
109Reduced antithrombin III activity (HP:0001976)1.97310022
110Duplicated collecting system (HP:0000081)1.96520110
111Neoplasm of the pancreas (HP:0002894)1.96069608
112Sandal gap (HP:0001852)1.95535165
113High pitched voice (HP:0001620)1.94059582
114Duplication of thumb phalanx (HP:0009942)1.93527859
115Exercise intolerance (HP:0003546)1.93041892
116Abnormality of lateral ventricle (HP:0030047)1.92498396
117Premature graying of hair (HP:0002216)1.92126469
118Infertility (HP:0000789)1.91940233
119Hypoplasia of the pons (HP:0012110)1.91911584
120Neoplasm of the colon (HP:0100273)1.90608079
121Abnormality of chromosome segregation (HP:0002916)1.90438715
122Megaloblastic anemia (HP:0001889)1.90382960
123Slender long bone (HP:0003100)1.90130005
124Overlapping toe (HP:0001845)1.89303719
125Pulmonary fibrosis (HP:0002206)1.88853961
126Abnormality of the pons (HP:0007361)1.88590254
127Prominent nose (HP:0000448)1.88203045
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.86755416
129Absent septum pellucidum (HP:0001331)1.86381497
130Neoplasm of striated muscle (HP:0009728)1.85865656
131Choanal atresia (HP:0000453)1.85649923
132Exertional dyspnea (HP:0002875)1.85413035
133Abnormality of the umbilical cord (HP:0010881)1.85314256
134Cellular immunodeficiency (HP:0005374)1.84882334
135Abnormality of the septum pellucidum (HP:0007375)1.84624187
136Abnormal number of erythroid precursors (HP:0012131)1.84421433
137Single umbilical artery (HP:0001195)1.83821498
138Abnormality of the fetal cardiovascular system (HP:0010948)1.83821498
139Abnormal umbilical cord blood vessels (HP:0011403)1.83821498
140Facial cleft (HP:0002006)1.83014549
141Abnormality of serum amino acid levels (HP:0003112)1.82826335
142Abnormality of cells of the erythroid lineage (HP:0012130)1.82163164
143Oligodactyly (hands) (HP:0001180)1.81979367
144Arteriovenous malformation (HP:0100026)1.81368381
145Aplasia/Hypoplasia of the earlobes (HP:0009906)1.81176160
146Abnormality of the renal collecting system (HP:0004742)1.80312101
147Abnormal trabecular bone morphology (HP:0100671)1.80022787
148Azoospermia (HP:0000027)1.79984547
149Cortical dysplasia (HP:0002539)1.77534696
150Abnormality of placental membranes (HP:0011409)1.74576485
151Amniotic constriction ring (HP:0009775)1.74576485
152Hyperalaninemia (HP:0003348)1.73868642
153Abnormality of the fingertips (HP:0001211)1.73000971
154Abnormality of the proximal phalanges of the hand (HP:0009834)1.72740002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.72592786
2CDC74.34679549
3WEE13.84467531
4VRK23.76451771
5PLK43.69392451
6TTK3.60221018
7NEK23.56057273
8EIF2AK12.71340990
9PLK12.44949859
10ACVR1B2.44149140
11BRSK22.43824046
12NEK12.13069542
13CHEK22.01423345
14BRAF1.99340205
15SRPK11.94019448
16CCNB11.91752114
17MST41.90669536
18BRSK11.87336941
19AURKB1.85931930
20MAP3K61.75174771
21EEF2K1.70766290
22LATS21.70542303
23TAF11.69306145
24STK101.66801443
25PLK31.63615084
26NME11.58805160
27MAP3K81.54719799
28STK38L1.53751654
29LATS11.50575488
30MELK1.47483349
31CDK71.45632830
32ATR1.45123880
33VRK11.44061651
34AURKA1.38642998
35TESK21.36324371
36STK31.35489170
37DYRK31.34939206
38CDK81.27882227
39CHEK11.26165021
40TRIM281.24831616
41EIF2AK31.22357185
42CDK41.21853079
43RAF11.19283231
44RPS6KA41.18446342
45STK41.15147340
46CDK121.06707783
47RPS6KB21.04099277
48ERBB41.04045486
49MUSK0.99580552
50MAPKAPK30.97974461
51PDK30.97746076
52PDK40.97746076
53MKNK10.97112945
54KSR20.94322099
55ARAF0.93968633
56MOS0.93117748
57ATM0.92217255
58MST1R0.91268505
59BMPR1B0.88194277
60MKNK20.87954367
61TSSK60.85540599
62PASK0.78741854
63TAOK10.78111138
64CDK20.77410132
65CDK90.76653524
66MAP3K120.74241907
67TLK10.73491316
68DYRK20.73416823
69PAK10.67690157
70CDK10.67071846
71SMG10.66188110
72PIM10.65618433
73TESK10.64957498
74NME20.63437596
75TNIK0.62877650
76TAOK30.62336304
77PLK20.58604636
78PRKD30.57209547
79TGFBR10.57064229
80STK160.54508630
81ABL20.53440684
82ZAK0.53079280
83KSR10.49972191
84MAP3K90.49929602
85CDK60.48399573
86NEK90.46500417
87CSNK2A10.45658300
88EIF2AK20.45097062
89WNK30.44336471
90PAK40.44066788
91ALK0.43930257
92MET0.43085513
93NUAK10.43061232
94MAP3K130.41462969
95ERBB30.40991232
96PRKCI0.40763522
97CLK10.38999643
98ILK0.35812828
99DAPK10.33456118
100MAP3K100.32777453
101SCYL20.32665424
102MAP3K50.32260638
103CSNK1E0.31561957
104CSNK1G30.30640920
105PBK0.30362667
106PDK20.29673050
107EPHA20.29639526
108CSNK2A20.29222106
109STK390.28291721
110FGFR10.27415785
111STK240.27029530
112CDK180.26156006
113BMPR20.25654127
114PRKDC0.24548261
115CDK140.23936078
116PNCK0.23090152
117AKT20.22874700
118RPS6KA50.22631111
119CDK30.22619850
120PAK20.22176433
121MARK30.21046391
122CSNK1G10.20344896
123MAPK110.19852738
124DAPK30.19390274
125NLK0.17703424
126LRRK20.16862258
127CDK11A0.16462864
128MTOR0.16123794
129CDK150.15493373

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.86471504
2Mismatch repair_Homo sapiens_hsa034304.17466219
3Cell cycle_Homo sapiens_hsa041103.89612507
4Homologous recombination_Homo sapiens_hsa034403.48487131
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.44414263
6Base excision repair_Homo sapiens_hsa034103.29369872
7RNA transport_Homo sapiens_hsa030133.27504319
8RNA polymerase_Homo sapiens_hsa030203.23593888
9Nucleotide excision repair_Homo sapiens_hsa034202.90343991
10Fanconi anemia pathway_Homo sapiens_hsa034602.89799114
11Basal transcription factors_Homo sapiens_hsa030222.87040599
12Spliceosome_Homo sapiens_hsa030402.72979858
13RNA degradation_Homo sapiens_hsa030182.62207033
14Pyrimidine metabolism_Homo sapiens_hsa002402.40732329
15Proteasome_Homo sapiens_hsa030502.38787973
16Oxidative phosphorylation_Homo sapiens_hsa001902.35980233
17Vitamin B6 metabolism_Homo sapiens_hsa007502.30353623
18Parkinsons disease_Homo sapiens_hsa050122.17066344
19Non-homologous end-joining_Homo sapiens_hsa034502.16569265
20One carbon pool by folate_Homo sapiens_hsa006702.10057183
21p53 signaling pathway_Homo sapiens_hsa041152.08119047
22mRNA surveillance pathway_Homo sapiens_hsa030151.81361870
23Oocyte meiosis_Homo sapiens_hsa041141.78958560
24Ribosome_Homo sapiens_hsa030101.67576351
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56497667
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.56300933
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49506967
28Pyruvate metabolism_Homo sapiens_hsa006201.40366334
29Purine metabolism_Homo sapiens_hsa002301.38967563
30Alzheimers disease_Homo sapiens_hsa050101.34452316
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33394069
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.29605584
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19156972
34Epstein-Barr virus infection_Homo sapiens_hsa051691.17134863
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16599131
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14179294
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.12384152
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.02177341
39Herpes simplex infection_Homo sapiens_hsa051680.98183760
40Propanoate metabolism_Homo sapiens_hsa006400.93045391
41Viral carcinogenesis_Homo sapiens_hsa052030.90251251
42Systemic lupus erythematosus_Homo sapiens_hsa053220.87988346
43Steroid biosynthesis_Homo sapiens_hsa001000.87868737
44Fatty acid elongation_Homo sapiens_hsa000620.87614813
45MicroRNAs in cancer_Homo sapiens_hsa052060.87249547
46Sulfur relay system_Homo sapiens_hsa041220.86567455
47TGF-beta signaling pathway_Homo sapiens_hsa043500.84055332
48HTLV-I infection_Homo sapiens_hsa051660.81484226
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81290181
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76933421
51Folate biosynthesis_Homo sapiens_hsa007900.73279201
52Pentose phosphate pathway_Homo sapiens_hsa000300.70718405
53Small cell lung cancer_Homo sapiens_hsa052220.66265583
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63820950
55N-Glycan biosynthesis_Homo sapiens_hsa005100.63679889
56Biosynthesis of amino acids_Homo sapiens_hsa012300.63153841
57Cardiac muscle contraction_Homo sapiens_hsa042600.61996476
58Linoleic acid metabolism_Homo sapiens_hsa005910.61869097
59Pancreatic cancer_Homo sapiens_hsa052120.61738248
60Antigen processing and presentation_Homo sapiens_hsa046120.61210283
61Thyroid cancer_Homo sapiens_hsa052160.59999898
62Colorectal cancer_Homo sapiens_hsa052100.59677907
63Hippo signaling pathway_Homo sapiens_hsa043900.55964231
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53372869
65Selenocompound metabolism_Homo sapiens_hsa004500.53079974
66alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52399545
67Circadian rhythm_Homo sapiens_hsa047100.51067476
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.46861582
69Hepatitis B_Homo sapiens_hsa051610.46343677
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45696891
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43151213
72Glutathione metabolism_Homo sapiens_hsa004800.43082598
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41018468
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40780622
75Sulfur metabolism_Homo sapiens_hsa009200.40290976
76Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.40010616
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39622713
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39022697
79Apoptosis_Homo sapiens_hsa042100.37782432
80Shigellosis_Homo sapiens_hsa051310.37756749
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37112263
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34322814
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.34314758
84Adherens junction_Homo sapiens_hsa045200.33170444
85Chronic myeloid leukemia_Homo sapiens_hsa052200.31402824
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31332257
87Bladder cancer_Homo sapiens_hsa052190.31010167
88FoxO signaling pathway_Homo sapiens_hsa040680.30404371
89Arginine and proline metabolism_Homo sapiens_hsa003300.30317329
90Ovarian steroidogenesis_Homo sapiens_hsa049130.30018868
91Notch signaling pathway_Homo sapiens_hsa043300.29901949
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.29724556
93Fatty acid metabolism_Homo sapiens_hsa012120.29686974
94Huntingtons disease_Homo sapiens_hsa050160.28326020
95Ether lipid metabolism_Homo sapiens_hsa005650.27482200
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27227345
97Vitamin digestion and absorption_Homo sapiens_hsa049770.26557429
98Measles_Homo sapiens_hsa051620.25272459
99Influenza A_Homo sapiens_hsa051640.24868395
100Protein export_Homo sapiens_hsa030600.24664397
101Arachidonic acid metabolism_Homo sapiens_hsa005900.24373827
102Prostate cancer_Homo sapiens_hsa052150.24265459
103Galactose metabolism_Homo sapiens_hsa000520.23363275
104NF-kappa B signaling pathway_Homo sapiens_hsa040640.21817707
105Legionellosis_Homo sapiens_hsa051340.21473236
106Lysine degradation_Homo sapiens_hsa003100.21066319
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20818614
108Hedgehog signaling pathway_Homo sapiens_hsa043400.20757346
109Pathways in cancer_Homo sapiens_hsa052000.20563838
110Peroxisome_Homo sapiens_hsa041460.20154321
111mTOR signaling pathway_Homo sapiens_hsa041500.20114988
112Basal cell carcinoma_Homo sapiens_hsa052170.20094584
113beta-Alanine metabolism_Homo sapiens_hsa004100.18373618
114Primary immunodeficiency_Homo sapiens_hsa053400.17734475
115Alcoholism_Homo sapiens_hsa050340.17612304
116Butanoate metabolism_Homo sapiens_hsa006500.17295545
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16482761
118Non-small cell lung cancer_Homo sapiens_hsa052230.16418867
119Tyrosine metabolism_Homo sapiens_hsa003500.15710606
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.15158733
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15145805
122Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14725085
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.13629077
124Regulation of autophagy_Homo sapiens_hsa041400.12048571
125Fructose and mannose metabolism_Homo sapiens_hsa000510.11979537
126Carbon metabolism_Homo sapiens_hsa012000.11929855
127Fatty acid degradation_Homo sapiens_hsa000710.11834350
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10892020
129HIF-1 signaling pathway_Homo sapiens_hsa040660.10582956
130Endometrial cancer_Homo sapiens_hsa052130.10067438
131Arginine biosynthesis_Homo sapiens_hsa002200.09822404
132Metabolic pathways_Homo sapiens_hsa011000.09495519
133Prolactin signaling pathway_Homo sapiens_hsa049170.08702739
134Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.08395482
135Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.07966169
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.07820077
137Viral myocarditis_Homo sapiens_hsa054160.07369394
138Wnt signaling pathway_Homo sapiens_hsa043100.07229422

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