CENPJ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)5.98720971
2nuclear pore complex assembly (GO:0051292)5.50804210
3rRNA methylation (GO:0031167)5.23387045
4mitotic chromosome condensation (GO:0007076)5.17551919
5single strand break repair (GO:0000012)5.10992973
6kinetochore organization (GO:0051383)5.09749365
7acrosome reaction (GO:0007340)5.06250127
8nuclear pore organization (GO:0006999)5.05198483
9mitotic sister chromatid cohesion (GO:0007064)4.83614279
10mitotic metaphase plate congression (GO:0007080)4.81305849
11rRNA modification (GO:0000154)4.76390015
12protein localization to kinetochore (GO:0034501)4.69629118
13attachment of spindle microtubules to kinetochore (GO:0008608)4.68715525
14spermatid nucleus differentiation (GO:0007289)4.57666677
15fusion of sperm to egg plasma membrane (GO:0007342)4.53485281
16spermatid development (GO:0007286)4.42448670
17kinetochore assembly (GO:0051382)4.41190405
18metaphase plate congression (GO:0051310)4.41064905
19* microtubule polymerization or depolymerization (GO:0031109)4.40536002
20pore complex assembly (GO:0046931)4.34269075
21meiotic chromosome segregation (GO:0045132)4.34014793
22CENP-A containing nucleosome assembly (GO:0034080)4.26722913
23* centriole replication (GO:0007099)4.26177544
24DNA replication checkpoint (GO:0000076)4.23149247
25protein polyglutamylation (GO:0018095)4.22570519
26regulation of double-strand break repair via homologous recombination (GO:0010569)4.18787626
27protein localization to chromosome, centromeric region (GO:0071459)4.18049671
28DNA replication-independent nucleosome assembly (GO:0006336)4.15937239
29DNA replication-independent nucleosome organization (GO:0034724)4.15937239
30chromatin remodeling at centromere (GO:0031055)4.15440946
31binding of sperm to zona pellucida (GO:0007339)4.14847885
32sperm-egg recognition (GO:0035036)4.12648384
33mitotic sister chromatid segregation (GO:0000070)4.11489672
34establishment of chromosome localization (GO:0051303)4.10357358
35protein localization to chromosome (GO:0034502)4.04728528
36sister chromatid segregation (GO:0000819)4.03827877
37seminiferous tubule development (GO:0072520)3.94486198
38mitotic nuclear envelope disassembly (GO:0007077)3.93669313
39DNA unwinding involved in DNA replication (GO:0006268)3.88838483
40synapsis (GO:0007129)3.87893424
41response to pheromone (GO:0019236)3.84304673
42regulation of spindle organization (GO:0090224)3.83598880
43histone exchange (GO:0043486)3.76443555
44positive regulation of mitotic sister chromatid separation (GO:1901970)3.76047858
45positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.76047858
46positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.76047858
47DNA double-strand break processing (GO:0000729)3.75769179
48resolution of meiotic recombination intermediates (GO:0000712)3.73812878
49nuclear envelope disassembly (GO:0051081)3.65926173
50membrane disassembly (GO:0030397)3.65926173
51replication fork processing (GO:0031297)3.65082071
52protein targeting to Golgi (GO:0000042)3.62635546
53establishment of protein localization to Golgi (GO:0072600)3.61309864
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.59504485
55regulation of meiosis I (GO:0060631)3.58158137
56DNA strand elongation (GO:0022616)3.55761703
57positive regulation of chromosome segregation (GO:0051984)3.55083932
58sperm capacitation (GO:0048240)3.55076833
59male gamete generation (GO:0048232)3.54785557
60spermatogenesis (GO:0007283)3.54324536
61DNA strand elongation involved in DNA replication (GO:0006271)3.52506292
62chromosome segregation (GO:0007059)3.52494915
63DNA ligation (GO:0006266)3.51444185
64DNA topological change (GO:0006265)3.46933185
65* regulation of centriole replication (GO:0046599)3.45994890
66spindle checkpoint (GO:0031577)3.45637875
67monoubiquitinated protein deubiquitination (GO:0035520)3.45388010
68regulation of sister chromatid cohesion (GO:0007063)3.44102857
69regulation of nuclear cell cycle DNA replication (GO:0033262)3.43239652
70chromatin assembly or disassembly (GO:0006333)3.42890785
71* centriole assembly (GO:0098534)3.41760786
72ATP-dependent chromatin remodeling (GO:0043044)3.41399803
73mitotic recombination (GO:0006312)3.39986219
74axonemal dynein complex assembly (GO:0070286)3.38218041
75DNA replication-dependent nucleosome assembly (GO:0006335)3.37613633
76DNA replication-dependent nucleosome organization (GO:0034723)3.37613633
77regulation of double-strand break repair (GO:2000779)3.37236535
78regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.36295026
79regulation of chromosome segregation (GO:0051983)3.35499932
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.35354687
81telomere maintenance via recombination (GO:0000722)3.34137782
82regulation of mitotic spindle organization (GO:0060236)3.33744853
83gamete generation (GO:0007276)3.33418191
84retrograde transport, vesicle recycling within Golgi (GO:0000301)3.32069547
85DNA replication initiation (GO:0006270)3.30979594
86plasma membrane fusion (GO:0045026)3.30700584
87nucleus organization (GO:0006997)3.27685848
88cell-cell recognition (GO:0009988)3.26749900
89regulation of DNA endoreduplication (GO:0032875)3.26471474
90mitotic G2/M transition checkpoint (GO:0044818)3.24008146
91male meiosis I (GO:0007141)3.20702508
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20289273
93sister chromatid cohesion (GO:0007062)3.19641738
94double-strand break repair via homologous recombination (GO:0000724)3.19038098
95spindle assembly checkpoint (GO:0071173)3.18934914
96chromosome condensation (GO:0030261)3.18853632
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18578961
98negative regulation of sister chromatid segregation (GO:0033046)3.18578961
99negative regulation of mitotic sister chromatid separation (GO:2000816)3.18578961
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18578961
101recombinational repair (GO:0000725)3.18208626
102DNA geometric change (GO:0032392)3.18066841
103regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.18059146
104chromosome organization involved in meiosis (GO:0070192)3.17882527
105negative regulation of chromosome segregation (GO:0051985)3.17735124
106DNA duplex unwinding (GO:0032508)3.17274999
107telomere maintenance via semi-conservative replication (GO:0032201)3.17040913
108regulation of sister chromatid segregation (GO:0033045)3.16492025
109regulation of mitotic sister chromatid separation (GO:0010965)3.16492025
110regulation of mitotic sister chromatid segregation (GO:0033047)3.16492025
111meiotic cell cycle process (GO:1903046)3.14539968
112DNA synthesis involved in DNA repair (GO:0000731)3.14059134
113regulation of cilium movement (GO:0003352)3.13925117
114microtubule depolymerization (GO:0007019)3.11944254
115* regulation of centrosome cycle (GO:0046605)3.10463012
116multicellular organism reproduction (GO:0032504)3.10428667
117mitotic spindle checkpoint (GO:0071174)3.10257802
118centrosome duplication (GO:0051298)3.10254719
119male meiosis (GO:0007140)3.09010889
120mitotic spindle assembly checkpoint (GO:0007094)3.08079596
121regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.05496496
122negative regulation of histone methylation (GO:0031061)3.05341072
123DNA packaging (GO:0006323)3.03711538
124regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.99758315
125regulation of mitotic spindle checkpoint (GO:1903504)2.99758315
126negative regulation of DNA-dependent DNA replication (GO:2000104)2.99689035
127negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.99639790
128negative regulation of DNA-templated transcription, elongation (GO:0032785)2.99639790
129regulation of RNA export from nucleus (GO:0046831)2.99620471
130DNA conformation change (GO:0071103)2.97791987
131dosage compensation (GO:0007549)2.97325376
132mismatch repair (GO:0006298)2.93844770
133regulation of histone H3-K9 methylation (GO:0051570)2.92782104
134synaptonemal complex assembly (GO:0007130)2.90811121
135piRNA metabolic process (GO:0034587)2.82191419
136DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.81405188
137chromosome organization (GO:0051276)2.81348656
138telomere maintenance via telomere lengthening (GO:0010833)2.80712268
139nuclear envelope organization (GO:0006998)2.80410225
140maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80215679
141nucleotide-excision repair, DNA gap filling (GO:0006297)2.78568010
142protein K6-linked ubiquitination (GO:0085020)2.75810786
143telomere maintenance (GO:0000723)2.74584251
144* mitotic cell cycle (GO:0000278)2.74463232

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human6.46156643
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.75481739
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.34224325
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.95544150
5KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.75622303
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.75471263
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.74142967
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.71690652
9E2F1_21310950_ChIP-Seq_MCF-7_Human2.69985464
10AR_21909140_ChIP-Seq_LNCAP_Human2.64621967
11FUS_26573619_Chip-Seq_HEK293_Human2.63404784
12TP63_19390658_ChIP-ChIP_HaCaT_Human2.45759451
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42032938
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.26058605
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24911429
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.18849623
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05434450
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02397706
19E2F7_22180533_ChIP-Seq_HELA_Human10.9730543
20ZNF274_21170338_ChIP-Seq_K562_Hela1.98946061
21NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93212217
22MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83348814
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.80681494
24VDR_23849224_ChIP-Seq_CD4+_Human1.80389584
25CREB1_15753290_ChIP-ChIP_HEK293T_Human1.79575680
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78494334
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78409715
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.77494696
29FOXP3_21729870_ChIP-Seq_TREG_Human1.70749638
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69557693
31CBP_20019798_ChIP-Seq_JUKART_Human1.69150463
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.69150463
33EWS_26573619_Chip-Seq_HEK293_Human1.68664196
34VDR_22108803_ChIP-Seq_LS180_Human1.67079205
35ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.66565864
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66370555
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.65308027
38GABP_17652178_ChIP-ChIP_JURKAT_Human1.64085236
39ELK1_19687146_ChIP-ChIP_HELA_Human1.63533201
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61710343
41POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59598336
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59598336
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56177264
44MYC_22102868_ChIP-Seq_BL_Human1.55077715
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.54028068
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53988052
47CIITA_25753668_ChIP-Seq_RAJI_Human1.53786847
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53718797
49TAF15_26573619_Chip-Seq_HEK293_Human1.53543328
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53081752
51XRN2_22483619_ChIP-Seq_HELA_Human1.52290204
52KDM5A_27292631_Chip-Seq_BREAST_Human1.51680399
53ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50797206
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50290674
55PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47057476
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45591094
57IRF1_19129219_ChIP-ChIP_H3396_Human1.45400198
58P300_19829295_ChIP-Seq_ESCs_Human1.43437392
59* ETS1_20019798_ChIP-Seq_JURKAT_Human1.37026648
60JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.33823469
61TTF2_22483619_ChIP-Seq_HELA_Human1.33822764
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33714707
63* IRF8_21731497_ChIP-ChIP_J774_Mouse1.31549507
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30998060
65DCP1A_22483619_ChIP-Seq_HELA_Human1.29819237
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27962082
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26927710
68ER_23166858_ChIP-Seq_MCF-7_Human1.26644523
69PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.25327450
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.24251377
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23885012
72* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22643733
73* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.22539898
74SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21749533
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21067216
76GABP_19822575_ChIP-Seq_HepG2_Human1.21028741
77POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.20572349
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17768777
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15718963
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.13651179
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13025677
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12121780
83IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09423923
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.07217776
85TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05423661
86MYB_26560356_Chip-Seq_TH1_Human1.05264949
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04233784
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.03952921
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03895631
90SPI1_23547873_ChIP-Seq_NB4_Human1.02432853
91HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02092519
92ZFX_18555785_ChIP-Seq_MESCs_Mouse1.01814578
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01681602
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01190247
95HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.00851959
96SOX2_16153702_ChIP-ChIP_HESCs_Human1.00568837
97ETV1_20927104_ChIP-Seq_GIST48_Human0.98977934
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.98925090
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98657836
100AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97420983
101POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97103768
102CBX2_22325352_ChIP-Seq_293T-Rex_Human0.96715262
103MYB_26560356_Chip-Seq_TH2_Human0.95769641
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94981113
105RBPJ_21746931_ChIP-Seq_IB4_Human0.94767553
106GBX2_23144817_ChIP-Seq_PC3_Human0.93507931
107KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93018883
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.92852803
109MYC_18940864_ChIP-ChIP_HL60_Human0.92694624
110NFYB_21822215_ChIP-Seq_K562_Human0.91998636
111UTX_26944678_Chip-Seq_JUKART_Human0.91170437
112FLI1_27457419_Chip-Seq_LIVER_Mouse0.90992469
113NANOG_21062744_ChIP-ChIP_HESCs_Human0.90557430
114* STAT3_23295773_ChIP-Seq_U87_Human0.90481128
115STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.89874954
116SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89615844
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89279724
118STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.89145862
119* AR_25329375_ChIP-Seq_VCAP_Human0.88877738
120NANOG_16153702_ChIP-ChIP_HESCs_Human0.88233415
121* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87535734
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87512523
123SOX9_26525672_Chip-Seq_HEART_Mouse0.86760836
124MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85949884
125PHF8_20622853_ChIP-Seq_HELA_Human0.85367306
126FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.85261360
127CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.84948577
128CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.84806584
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84346769
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84279915
131PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83665818
132* RUNX2_22187159_ChIP-Seq_PCA_Human0.83351837
133HNFA_21074721_ChIP-Seq_CACO-2_Human0.83111053
134SALL4_22934838_ChIP-ChIP_CD34+_Human0.82777449
135CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82149604
136CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81890933
137SMAD4_21799915_ChIP-Seq_A2780_Human0.81639370
138ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81142358
139EZH2_22144423_ChIP-Seq_EOC_Human0.80789063
140TFEB_21752829_ChIP-Seq_HELA_Human0.80709437
141IGF1R_20145208_ChIP-Seq_DFB_Human0.80518556
142AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80464981
143VDR_21846776_ChIP-Seq_THP-1_Human0.79455793
144WDR5_24793694_ChIP-Seq_LNCAP_Human0.79058161
145HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78892771
146FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.78694451
147TCF4_23295773_ChIP-Seq_U87_Human0.78171289
148TBL1_22424771_ChIP-Seq_293T_Human0.78110453
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.77754653
150STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74768269
151NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73725104
152CHD1_26751641_Chip-Seq_LNCaP_Human0.73425134
153SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.73170844
154* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.72825802
155BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.70439186
156SCL_19346495_ChIP-Seq_HPC-7_Human0.69788187
157PKCTHETA_26484144_Chip-Seq_BREAST_Human0.69086274

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization5.27522676
2MP0003693_abnormal_embryo_hatching4.52013983
3MP0010094_abnormal_chromosome_stability4.28465302
4MP0008877_abnormal_DNA_methylation3.70571657
5MP0003111_abnormal_nucleus_morphology3.67076492
6MP0003077_abnormal_cell_cycle3.62632660
7MP0008058_abnormal_DNA_repair3.49399765
8MP0008057_abnormal_DNA_replication3.46531460
9MP0004957_abnormal_blastocyst_morpholog2.99629071
10MP0003698_abnormal_male_reproductive2.88895636
11MP0008007_abnormal_cellular_replicative2.52009170
12MP0003787_abnormal_imprinting2.50898864
13MP0003878_abnormal_ear_physiology2.39746017
14MP0005377_hearing/vestibular/ear_phenot2.39746017
15MP0003121_genomic_imprinting2.28599827
16MP0000569_abnormal_digit_pigmentation2.25542737
17MP0004808_abnormal_hematopoietic_stem2.04320191
18MP0008932_abnormal_embryonic_tissue1.99660457
19MP0010307_abnormal_tumor_latency1.96274056
20MP0002396_abnormal_hematopoietic_system1.95614829
21MP0000350_abnormal_cell_proliferation1.94924768
22MP0001730_embryonic_growth_arrest1.94413354
23MP0003123_paternal_imprinting1.92951666
24MP0002161_abnormal_fertility/fecundity1.76583981
25MP0005076_abnormal_cell_differentiation1.76428743
26MP0005670_abnormal_white_adipose1.75226186
27MP0003890_abnormal_embryonic-extraembry1.72054452
28MP0005380_embryogenesis_phenotype1.70854613
29MP0001672_abnormal_embryogenesis/_devel1.70854613
30MP0010352_gastrointestinal_tract_polyps1.70453422
31MP0003984_embryonic_growth_retardation1.59538479
32MP0008995_early_reproductive_senescence1.57371384
33MP0002088_abnormal_embryonic_growth/wei1.55797789
34MP0001697_abnormal_embryo_size1.53822009
35MP0002210_abnormal_sex_determination1.48343521
36MP0003763_abnormal_thymus_physiology1.45622726
37MP0002234_abnormal_pharynx_morphology1.41482844
38MP0002084_abnormal_developmental_patter1.41103683
39MP0010030_abnormal_orbit_morphology1.39029941
40MP0002085_abnormal_embryonic_tissue1.35144724
41MP0002086_abnormal_extraembryonic_tissu1.33766929
42MP0003705_abnormal_hypodermis_morpholog1.31612981
43MP0000703_abnormal_thymus_morphology1.30402181
44MP0000490_abnormal_crypts_of1.29335898
45MP0001929_abnormal_gametogenesis1.28904701
46MP0002019_abnormal_tumor_incidence1.28750689
47MP0004197_abnormal_fetal_growth/weight/1.27599301
48MP0001119_abnormal_female_reproductive1.27015199
49MP0002398_abnormal_bone_marrow1.26403909
50MP0002080_prenatal_lethality1.20715536
51MP0001293_anophthalmia1.20125262
52MP0003119_abnormal_digestive_system1.19027994
53MP0000313_abnormal_cell_death1.18232175
54MP0000653_abnormal_sex_gland1.18129164
55MP0003786_premature_aging1.16320674
56MP0009697_abnormal_copulation1.15892049
57MP0005397_hematopoietic_system_phenotyp1.15738375
58MP0001545_abnormal_hematopoietic_system1.15738375
59MP0003718_maternal_effect1.14658879
60MP0002938_white_spotting1.14198762
61MP0001145_abnormal_male_reproductive1.13328305
62MP0001485_abnormal_pinna_reflex1.11551769
63MP0009672_abnormal_birth_weight1.10589135
64MP0006292_abnormal_olfactory_placode1.09666583
65MP0003567_abnormal_fetal_cardiomyocyte1.06624939
66MP0006072_abnormal_retinal_apoptosis1.05714923
67MP0001968_abnormal_touch/_nociception1.03065600
68MP0009703_decreased_birth_body1.01495308
69MP0002736_abnormal_nociception_after1.00227220
70MP0002722_abnormal_immune_system0.99906272
71MP0009053_abnormal_anal_canal0.99022595
72MP0003646_muscle_fatigue0.98873948
73MP0000689_abnormal_spleen_morphology0.97756957
74MP0002282_abnormal_trachea_morphology0.97003581
75MP0001800_abnormal_humoral_immune0.95358219
76MP0005394_taste/olfaction_phenotype0.94969960
77MP0005499_abnormal_olfactory_system0.94969960
78MP0002160_abnormal_reproductive_system0.92720860
79MP0002877_abnormal_melanocyte_morpholog0.92008053
80MP0003861_abnormal_nervous_system0.91031155
81MP0005395_other_phenotype0.90950020
82MP0001915_intracranial_hemorrhage0.90893973
83MP0001348_abnormal_lacrimal_gland0.90459667
84MP0001835_abnormal_antigen_presentation0.90431167
85MP0003943_abnormal_hepatobiliary_system0.89497585
86MP0000716_abnormal_immune_system0.88416040
87MP0000049_abnormal_middle_ear0.87913076
88MP0005253_abnormal_eye_physiology0.87808131
89MP0003937_abnormal_limbs/digits/tail_de0.87223996
90MP0002429_abnormal_blood_cell0.86347652
91MP0009333_abnormal_splenocyte_physiolog0.86175487
92MP0005551_abnormal_eye_electrophysiolog0.84885153
93MP0002006_tumorigenesis0.84405860
94MP0005391_vision/eye_phenotype0.84021976
95MP0002735_abnormal_chemical_nociception0.83730776
96MP0001486_abnormal_startle_reflex0.82834057
97MP0001529_abnormal_vocalization0.82819929
98MP0005408_hypopigmentation0.81382391
99MP0002452_abnormal_antigen_presenting0.81244254
100MP0004742_abnormal_vestibular_system0.80887830
101MP0002102_abnormal_ear_morphology0.80723150
102MP0000631_abnormal_neuroendocrine_gland0.80537141
103MP0006054_spinal_hemorrhage0.80287376
104MP0002420_abnormal_adaptive_immunity0.79482372
105MP0003880_abnormal_central_pattern0.79407033
106MP0001819_abnormal_immune_cell0.78958253
107MP0009278_abnormal_bone_marrow0.78410572
108MP0003935_abnormal_craniofacial_develop0.77948564
109MP0000432_abnormal_head_morphology0.74785121
110MP0003941_abnormal_skin_development0.73936924
111MP0004264_abnormal_extraembryonic_tissu0.72061501
112MP0002925_abnormal_cardiovascular_devel0.70560708
113MP0005389_reproductive_system_phenotype0.70400632
114MP0000678_abnormal_parathyroid_gland0.68711282
115MP0005257_abnormal_intraocular_pressure0.68655897
116MP0002697_abnormal_eye_size0.68528752
117MP0005621_abnormal_cell_physiology0.68400559
118MP0001984_abnormal_olfaction0.68142007
119MP0005671_abnormal_response_to0.67387246
120MP0002233_abnormal_nose_morphology0.67220067
121MP0001286_abnormal_eye_development0.67060738
122MP0005384_cellular_phenotype0.66905972
123MP0003699_abnormal_female_reproductive0.66749766
124MP0003385_abnormal_body_wall0.66410887
125MP0002723_abnormal_immune_serum0.66334096
126MP0002249_abnormal_larynx_morphology0.66156589
127MP0001188_hyperpigmentation0.65554084
128MP0003936_abnormal_reproductive_system0.65441407
129MP0002092_abnormal_eye_morphology0.65400723
130MP0005379_endocrine/exocrine_gland_phen0.64765240
131MP0001849_ear_inflammation0.64621337
132MP0003136_yellow_coat_color0.64547253
133MP0005023_abnormal_wound_healing0.64443673
134MP0003221_abnormal_cardiomyocyte_apopto0.64162437
135MP0001919_abnormal_reproductive_system0.63879739
136MP0003436_decreased_susceptibility_to0.62723079
137MP0010155_abnormal_intestine_physiology0.62721315
138MP0002166_altered_tumor_susceptibility0.62668104
139MP0005174_abnormal_tail_pigmentation0.61266680
140MP0008789_abnormal_olfactory_epithelium0.60919037
141MP0003755_abnormal_palate_morphology0.60662526
142MP0003315_abnormal_perineum_morphology0.60522892
143MP0005310_abnormal_salivary_gland0.58944124
144MP0008770_decreased_survivor_rate0.58698251

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.95287719
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.45752960
3Volvulus (HP:0002580)4.41963745
4Tubulointerstitial nephritis (HP:0001970)4.15651292
5Chronic hepatic failure (HP:0100626)3.70655412
6Abnormality of the fingertips (HP:0001211)3.62652299
7Patellar aplasia (HP:0006443)3.52695507
8Abnormality of chromosome stability (HP:0003220)3.48847108
9Ectopic kidney (HP:0000086)3.31453480
10Aplasia/Hypoplasia of the patella (HP:0006498)3.17821387
11Aplasia/Hypoplasia of the uvula (HP:0010293)3.06834906
12Birth length less than 3rd percentile (HP:0003561)3.04668719
13Absent/shortened dynein arms (HP:0200106)3.02467439
14Dynein arm defect of respiratory motile cilia (HP:0012255)3.02467439
15Severe visual impairment (HP:0001141)2.97424490
16Papillary thyroid carcinoma (HP:0002895)2.91434808
17Increased nuchal translucency (HP:0010880)2.90597636
18Meckel diverticulum (HP:0002245)2.89520728
19Impulsivity (HP:0100710)2.86288857
20Myelodysplasia (HP:0002863)2.80021033
21Abnormal lung lobation (HP:0002101)2.75697505
22Abnormality of the ileum (HP:0001549)2.71127520
23Short 4th metacarpal (HP:0010044)2.70766133
24Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.70766133
25Long eyelashes (HP:0000527)2.66056078
26Medulloblastoma (HP:0002885)2.64579903
27Abnormality of the intervertebral disk (HP:0005108)2.61310751
28Abnormality of the preputium (HP:0100587)2.57709307
29Duodenal stenosis (HP:0100867)2.56353011
30Small intestinal stenosis (HP:0012848)2.56353011
31Aplasia/Hypoplasia of the sacrum (HP:0008517)2.56234093
32Nephroblastoma (Wilms tumor) (HP:0002667)2.54706015
33Acute myeloid leukemia (HP:0004808)2.53707549
34Deep philtrum (HP:0002002)2.47570080
35* Aplasia/Hypoplasia of the earlobes (HP:0009906)2.46222542
36Colon cancer (HP:0003003)2.43210849
37Sloping forehead (HP:0000340)2.42221335
38Abnormality of cochlea (HP:0000375)2.42091978
39Prominent nose (HP:0000448)2.37333340
40Facial hemangioma (HP:0000329)2.35882349
41Abnormality of the renal medulla (HP:0100957)2.35167355
42Abnormal respiratory epithelium morphology (HP:0012253)2.33493611
43Abnormal respiratory motile cilium morphology (HP:0005938)2.33493611
44Embryonal renal neoplasm (HP:0011794)2.31868457
45High pitched voice (HP:0001620)2.28609372
46Breast hypoplasia (HP:0003187)2.25876518
47Renovascular hypertension (HP:0100817)2.25825365
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.23831237
49Bony spicule pigmentary retinopathy (HP:0007737)2.23635083
50Deviation of the thumb (HP:0009603)2.19726162
51Cutis marmorata (HP:0000965)2.17690866
52Cortical dysplasia (HP:0002539)2.16057204
53Abnormal respiratory motile cilium physiology (HP:0012261)2.14796721
54Abnormality of DNA repair (HP:0003254)2.13895733
55Abnormality of the carotid arteries (HP:0005344)2.13813888
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13109534
57Abnormal ciliary motility (HP:0012262)2.11498274
58Cafe-au-lait spot (HP:0000957)2.10397191
59Selective tooth agenesis (HP:0001592)2.08180537
60Proximal placement of thumb (HP:0009623)2.07744435
61Abnormality of macular pigmentation (HP:0008002)2.07494999
62Clubbing of toes (HP:0100760)2.06959842
63Abnormality of the duodenum (HP:0002246)2.05331806
64Pancreatic fibrosis (HP:0100732)2.05295430
65Rhabdomyosarcoma (HP:0002859)2.04845579
66Aplasia/Hypoplasia of the sternum (HP:0006714)2.03689611
67Overlapping toe (HP:0001845)2.01690552
68Reticulocytopenia (HP:0001896)2.01463382
69Absent forearm bone (HP:0003953)2.00300072
70Abnormality of the labia minora (HP:0012880)2.00212431
71Bone marrow hypocellularity (HP:0005528)1.99302576
72Astigmatism (HP:0000483)1.98667470
73Shawl scrotum (HP:0000049)1.98584054
74Attenuation of retinal blood vessels (HP:0007843)1.97910899
75Absent thumb (HP:0009777)1.97863515
76Supernumerary spleens (HP:0009799)1.93661198
77Gonadotropin excess (HP:0000837)1.93099714
78Atresia of the external auditory canal (HP:0000413)1.93014361
79Combined immunodeficiency (HP:0005387)1.92915249
80Obsessive-compulsive behavior (HP:0000722)1.92775189
81Short thumb (HP:0009778)1.91493589
82* Sandal gap (HP:0001852)1.90911029
83Agnosia (HP:0010524)1.90594707
84Chronic bronchitis (HP:0004469)1.90080586
85Horseshoe kidney (HP:0000085)1.89274758
8611 pairs of ribs (HP:0000878)1.89113643
87Embryonal neoplasm (HP:0002898)1.87958902
88Morphological abnormality of the inner ear (HP:0011390)1.87088782
89Truncal obesity (HP:0001956)1.85161555
90Esophageal atresia (HP:0002032)1.85104138
91Tubulointerstitial abnormality (HP:0001969)1.82908632
92Male infertility (HP:0003251)1.80535149
93Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80354169
94Absent epiphyses (HP:0010577)1.80354169
95True hermaphroditism (HP:0010459)1.79726862
96Bell-shaped thorax (HP:0001591)1.79522250
97Lymphoma (HP:0002665)1.78963980
98B lymphocytopenia (HP:0010976)1.76312364
99Abnormality of B cell number (HP:0010975)1.76312364
100Abnormality of midbrain morphology (HP:0002418)1.76150409
101Molar tooth sign on MRI (HP:0002419)1.76150409
102Choanal atresia (HP:0000453)1.76014210
103Oligohydramnios (HP:0001562)1.75637780
104Abnormal number of incisors (HP:0011064)1.74078974
105Oligodactyly (hands) (HP:0001180)1.73864828
106Duplicated collecting system (HP:0000081)1.73845848
107Resting tremor (HP:0002322)1.73575032
108Optic nerve hypoplasia (HP:0000609)1.73239104
109Absent radius (HP:0003974)1.73232816
110Arteriovenous malformation (HP:0100026)1.70506249
111Ependymoma (HP:0002888)1.70208275
112Cone-rod dystrophy (HP:0000548)1.70186150
113Glioma (HP:0009733)1.69641774
114Neoplasm of the colon (HP:0100273)1.69377507
115Abnormality of the anterior horn cell (HP:0006802)1.69282954
116Degeneration of anterior horn cells (HP:0002398)1.69282954
117Abnormal spermatogenesis (HP:0008669)1.69209912
118Abnormality of chromosome segregation (HP:0002916)1.69179453
119Amaurosis fugax (HP:0100576)1.68974246
120Severe combined immunodeficiency (HP:0004430)1.68182892
121Cellular immunodeficiency (HP:0005374)1.68177749
122Thyroid carcinoma (HP:0002890)1.66417881
123Gastrointestinal atresia (HP:0002589)1.66070298
124Nephronophthisis (HP:0000090)1.65766962
125Capillary hemangiomas (HP:0005306)1.65755673
126Small hand (HP:0200055)1.65695748
127Recurrent viral infections (HP:0004429)1.65665026
128Hypoplastic labia majora (HP:0000059)1.65329212
129Abnormality of the 4th metacarpal (HP:0010012)1.64392319
130Preaxial hand polydactyly (HP:0001177)1.64329423
131Vertebral arch anomaly (HP:0008438)1.64191693
132Pendular nystagmus (HP:0012043)1.64011749
133Bilateral microphthalmos (HP:0007633)1.64002570
134Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.63750352
135Rib fusion (HP:0000902)1.63176903
136Neoplasm of striated muscle (HP:0009728)1.63020063
137Microtia (HP:0008551)1.61957992
138Irregular epiphyses (HP:0010582)1.61880712
139Neoplasm of the pancreas (HP:0002894)1.61543771
140Abnormality of the metopic suture (HP:0005556)1.60454801
141Abnormality of the renal collecting system (HP:0004742)1.60312714
142Stage 5 chronic kidney disease (HP:0003774)1.59813168
143Granulocytopenia (HP:0001913)1.59769319
144Tracheoesophageal fistula (HP:0002575)1.59374637
145Intestinal atresia (HP:0011100)1.59029768
146Blepharitis (HP:0000498)1.58589532
147Trigonocephaly (HP:0000243)1.58486948
148Abnormality of the parathyroid morphology (HP:0011766)1.58330459
149Skull defect (HP:0001362)1.57592277
150Cleft eyelid (HP:0000625)1.57231540
151Long clavicles (HP:0000890)1.56540450
152Missing ribs (HP:0000921)1.56432752
153Malignant gastrointestinal tract tumors (HP:0006749)1.56415555
154Gastrointestinal carcinoma (HP:0002672)1.56415555
155Pancreatic cysts (HP:0001737)1.55667547
156T lymphocytopenia (HP:0005403)1.55237867
157Triphalangeal thumb (HP:0001199)1.54686901
158Basal cell carcinoma (HP:0002671)1.53797075
159Aplasia involving forearm bones (HP:0009822)1.53774048

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.26745146
2NEK23.75617597
3PNCK3.62708367
4CDK123.02367804
5* PLK42.91347026
6TTK2.87304781
7BUB12.74160977
8INSRR2.47930813
9SRPK12.44148992
10BRSK22.36623998
11STK102.13317312
12MAP4K22.08584660
13PLK12.02751239
14ERBB31.99736209
15WEE11.98950669
16CAMK1G1.89680964
17ATR1.88932006
18AURKB1.86483564
19LATS11.86452508
20CHEK21.70815988
21STK31.70208445
22BRD41.67200938
23MELK1.65178566
24STK41.61163582
25ACVR1B1.59248322
26PLK31.58968709
27STK38L1.56309650
28NEK11.55315059
29BRSK11.53876899
30TAOK31.51248314
31TNIK1.46179886
32CDK41.44658832
33CHEK11.43143653
34MAP4K11.38863839
35BMPR1B1.38613497
36MKNK11.37534847
37PASK1.32928785
38VRK21.29888285
39TGFBR11.29279791
40EIF2AK11.28985243
41ATM1.26959913
42ZAK1.26938121
43TXK1.23061060
44CDK71.22384665
45BMPR21.20791623
46EEF2K1.20773437
47TAF11.19393224
48IRAK41.18164516
49MAP3K81.11965520
50PIM11.10172036
51RPS6KA41.08174218
52WNK31.07492803
53MAP3K41.05537340
54CDK61.05282361
55MAP3K101.04294029
56MAP3K61.03624316
57CDK31.00308676
58DDR20.99110467
59VRK10.98465090
60RPS6KB20.97951461
61NME10.91129724
62CDK20.90914977
63AKT30.90073138
64TSSK60.82962391
65CDK90.80117103
66EIF2AK20.79675504
67JAK30.78996397
68NEK90.78609003
69NLK0.78454161
70BRAF0.77994382
71CDK10.77825585
72MST40.77460360
73TRIM280.76761397
74AURKA0.74425358
75TYK20.73955480
76MKNK20.73917268
77CASK0.73187000
78CAMK1D0.72577503
79CHUK0.70573596
80TESK10.68097723
81FGFR30.66878586
82TLK10.66873651
83STK240.64889678
84ZAP700.62530968
85EIF2AK30.61384035
86MAPK130.60997770
87MTOR0.58514396
88MAPKAPK50.55871315
89WNK10.54624673
90YES10.53573787
91ITK0.53074027
92CLK10.52818498
93PBK0.52467395
94CCNB10.51066955
95TEC0.50307448
96CDK80.49265645
97TRPM70.48227049
98MAP3K50.47938397
99DYRK30.47433614
100LATS20.46316792
101BLK0.45551733
102GSK3B0.44906836
103CSNK1E0.43467880
104TIE10.42107918
105CSNK2A10.41193193
106TESK20.41117985
107FRK0.40926065
108NEK60.40395042
109MARK30.40143413
110PIK3CG0.39758998
111PRKD30.39262011
112FGFR40.38693014
113STK160.38396609
114AKT10.38230575
115MAPK150.37687586
116MAP3K140.37639530
117TYRO30.37304540
118NUAK10.36617109
119DYRK20.36551122
120MAPK140.36025922
121PRKDC0.34790679
122BTK0.34278829
123STK390.33286423
124MAPKAPK20.32581582
125JAK10.32527104
126RPS6KA50.32400170
127CSF1R0.31997608
128CDK190.31149960
129IKBKE0.30877753
130PRKG10.30740569
131OXSR10.30359033
132PRKCG0.29474173
133RPS6KB10.29096378
134KIT0.28236133
135PTK2B0.27758973
136CSNK2A20.25721733
137PRKACB0.25294572
138MAP2K20.24734314
139MAPK10.24685826
140UHMK10.24532931
141RPS6KA10.24449367
142DMPK0.24367936
143PAK40.23851854
144PKN10.23534959
145PRKCB0.23265834
146FGFR10.23067056

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.00406108
2Mismatch repair_Homo sapiens_hsa034303.46935978
3Cell cycle_Homo sapiens_hsa041103.39923099
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.77376310
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.76553261
6Base excision repair_Homo sapiens_hsa034102.76461823
7Non-homologous end-joining_Homo sapiens_hsa034502.74238165
8Homologous recombination_Homo sapiens_hsa034402.74001509
9RNA transport_Homo sapiens_hsa030132.72582128
10Fanconi anemia pathway_Homo sapiens_hsa034602.58122622
11Spliceosome_Homo sapiens_hsa030402.51554808
12RNA degradation_Homo sapiens_hsa030182.25939399
13Basal transcription factors_Homo sapiens_hsa030222.25403794
14Fatty acid biosynthesis_Homo sapiens_hsa000612.22895559
15Nucleotide excision repair_Homo sapiens_hsa034202.06232270
16mRNA surveillance pathway_Homo sapiens_hsa030152.01003006
17One carbon pool by folate_Homo sapiens_hsa006701.98843279
18RNA polymerase_Homo sapiens_hsa030201.93840590
19p53 signaling pathway_Homo sapiens_hsa041151.85545480
20Herpes simplex infection_Homo sapiens_hsa051681.61974327
21Pyrimidine metabolism_Homo sapiens_hsa002401.51507974
22Proteasome_Homo sapiens_hsa030501.49303473
23Olfactory transduction_Homo sapiens_hsa047401.48355089
24Epstein-Barr virus infection_Homo sapiens_hsa051691.45295758
25MicroRNAs in cancer_Homo sapiens_hsa052061.35923656
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.35625100
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.33584946
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29350914
29Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27536660
30Antigen processing and presentation_Homo sapiens_hsa046121.23434016
31Viral carcinogenesis_Homo sapiens_hsa052031.22903785
32Propanoate metabolism_Homo sapiens_hsa006401.18354942
33Oocyte meiosis_Homo sapiens_hsa041141.17493877
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16937693
35Primary immunodeficiency_Homo sapiens_hsa053401.15255771
36Small cell lung cancer_Homo sapiens_hsa052221.14711291
37HTLV-I infection_Homo sapiens_hsa051661.12435886
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11578865
39Measles_Homo sapiens_hsa051621.09364808
40Protein export_Homo sapiens_hsa030601.07966533
41Systemic lupus erythematosus_Homo sapiens_hsa053221.07952725
42Thyroid cancer_Homo sapiens_hsa052161.07055934
43Butanoate metabolism_Homo sapiens_hsa006501.04020270
44Lysine degradation_Homo sapiens_hsa003101.02124987
45Fatty acid metabolism_Homo sapiens_hsa012121.02117359
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02006483
47Chronic myeloid leukemia_Homo sapiens_hsa052201.01403858
48Influenza A_Homo sapiens_hsa051640.98552247
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.98463635
50Notch signaling pathway_Homo sapiens_hsa043300.98122557
51Steroid biosynthesis_Homo sapiens_hsa001000.97976483
52Pancreatic cancer_Homo sapiens_hsa052120.96552966
53Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96399846
54Huntingtons disease_Homo sapiens_hsa050160.94249546
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92118207
56Hepatitis B_Homo sapiens_hsa051610.90312331
57Viral myocarditis_Homo sapiens_hsa054160.90058949
58Adherens junction_Homo sapiens_hsa045200.89028974
59TGF-beta signaling pathway_Homo sapiens_hsa043500.88091600
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85093607
61Colorectal cancer_Homo sapiens_hsa052100.84657417
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84591826
63Apoptosis_Homo sapiens_hsa042100.82886320
64Fatty acid degradation_Homo sapiens_hsa000710.81607425
65Purine metabolism_Homo sapiens_hsa002300.80369034
66Taste transduction_Homo sapiens_hsa047420.77629410
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77413125
68FoxO signaling pathway_Homo sapiens_hsa040680.76547840
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74029475
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.73507288
71Ribosome_Homo sapiens_hsa030100.71454180
72Toxoplasmosis_Homo sapiens_hsa051450.71364870
73Leishmaniasis_Homo sapiens_hsa051400.70706364
74Pyruvate metabolism_Homo sapiens_hsa006200.70471035
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70220160
76Hematopoietic cell lineage_Homo sapiens_hsa046400.68997252
77Legionellosis_Homo sapiens_hsa051340.68783934
78Hedgehog signaling pathway_Homo sapiens_hsa043400.68049129
79Biosynthesis of amino acids_Homo sapiens_hsa012300.67513971
80Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.67464257
81Prostate cancer_Homo sapiens_hsa052150.66731983
82TNF signaling pathway_Homo sapiens_hsa046680.66003176
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65419382
84Nicotine addiction_Homo sapiens_hsa050330.63611867
85Graft-versus-host disease_Homo sapiens_hsa053320.63248237
86Acute myeloid leukemia_Homo sapiens_hsa052210.63142573
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62559003
88Allograft rejection_Homo sapiens_hsa053300.62468302
89Phototransduction_Homo sapiens_hsa047440.61393451
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61298735
91Shigellosis_Homo sapiens_hsa051310.61013617
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59860885
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57734914
94T cell receptor signaling pathway_Homo sapiens_hsa046600.56402778
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.56153210
96B cell receptor signaling pathway_Homo sapiens_hsa046620.55987577
97mTOR signaling pathway_Homo sapiens_hsa041500.55964059
98Non-small cell lung cancer_Homo sapiens_hsa052230.55889998
99Autoimmune thyroid disease_Homo sapiens_hsa053200.53356147
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52259811
101Hippo signaling pathway_Homo sapiens_hsa043900.52235954
102Pathways in cancer_Homo sapiens_hsa052000.52061566
103Basal cell carcinoma_Homo sapiens_hsa052170.50704450
104Parkinsons disease_Homo sapiens_hsa050120.50600600
105Endometrial cancer_Homo sapiens_hsa052130.50177812
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.48700670
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.48197387
108Osteoclast differentiation_Homo sapiens_hsa043800.46918215
109Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45879658
110Prolactin signaling pathway_Homo sapiens_hsa049170.45070235
111Hepatitis C_Homo sapiens_hsa051600.44577166
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.43310454
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43265673
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41854000
115Carbon metabolism_Homo sapiens_hsa012000.41247321
116Metabolic pathways_Homo sapiens_hsa011000.40989333
117Dorso-ventral axis formation_Homo sapiens_hsa043200.40222978
118Alcoholism_Homo sapiens_hsa050340.39869625
119AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.39432198
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39031381
121Fatty acid elongation_Homo sapiens_hsa000620.36840719
122Folate biosynthesis_Homo sapiens_hsa007900.36549205
123Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35756164
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35304491
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.34650612
126HIF-1 signaling pathway_Homo sapiens_hsa040660.34478380
127Vitamin B6 metabolism_Homo sapiens_hsa007500.34052667
128Glutathione metabolism_Homo sapiens_hsa004800.34048555
129Proteoglycans in cancer_Homo sapiens_hsa052050.32078481
130Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31928011
131Oxidative phosphorylation_Homo sapiens_hsa001900.31203669
132Wnt signaling pathway_Homo sapiens_hsa043100.30993791
133Type I diabetes mellitus_Homo sapiens_hsa049400.30350405
134Selenocompound metabolism_Homo sapiens_hsa004500.29822714
135Platelet activation_Homo sapiens_hsa046110.28075254
136Arginine and proline metabolism_Homo sapiens_hsa003300.26555714
137Cardiac muscle contraction_Homo sapiens_hsa042600.25463647
138Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22418613
139N-Glycan biosynthesis_Homo sapiens_hsa005100.21615141
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20542359
141Retinol metabolism_Homo sapiens_hsa008300.18115679
142Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16863642
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16063784
144Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15524283
145Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.12005835
146Nitrogen metabolism_Homo sapiens_hsa009100.11405516
147Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11309294
148Fat digestion and absorption_Homo sapiens_hsa049750.11205815
149Tyrosine metabolism_Homo sapiens_hsa003500.10897001
150Sulfur relay system_Homo sapiens_hsa041220.09486621
151Ether lipid metabolism_Homo sapiens_hsa005650.08664319
152Calcium signaling pathway_Homo sapiens_hsa040200.07524893
153Tight junction_Homo sapiens_hsa045300.07289700
154Linoleic acid metabolism_Homo sapiens_hsa005910.05911666
155Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.05627255

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