CENPA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.26466204
2protein localization to kinetochore (GO:0034501)5.03863945
3mitotic sister chromatid segregation (GO:0000070)4.87899925
4* kinetochore organization (GO:0051383)4.78908768
5metaphase plate congression (GO:0051310)4.65778783
6ribosomal small subunit assembly (GO:0000028)4.60246281
7chromosome condensation (GO:0030261)4.51347811
8sister chromatid segregation (GO:0000819)4.41744146
9regulation of spindle organization (GO:0090224)4.37499165
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.32457599
11establishment of chromosome localization (GO:0051303)4.32303241
12* CENP-A containing nucleosome assembly (GO:0034080)4.31170763
13* kinetochore assembly (GO:0051382)4.28326377
14* protein localization to chromosome, centromeric region (GO:0071459)4.25163665
15DNA strand elongation involved in DNA replication (GO:0006271)4.23617445
16* chromatin remodeling at centromere (GO:0031055)4.22887124
17mitotic chromosome condensation (GO:0007076)4.20144100
18DNA unwinding involved in DNA replication (GO:0006268)4.13212489
19attachment of spindle microtubules to kinetochore (GO:0008608)4.13031926
20DNA replication initiation (GO:0006270)4.12994825
21DNA ligation (GO:0006266)4.12779387
22telomere maintenance via semi-conservative replication (GO:0032201)4.12559108
23DNA replication checkpoint (GO:0000076)4.06740876
24DNA strand elongation (GO:0022616)4.04072965
25viral transcription (GO:0019083)3.98733633
26mitotic nuclear envelope disassembly (GO:0007077)3.98179851
27translational termination (GO:0006415)3.91800186
28regulation of mitotic spindle organization (GO:0060236)3.88192115
29* DNA replication-independent nucleosome organization (GO:0034724)3.88000095
30* DNA replication-independent nucleosome assembly (GO:0006336)3.88000095
31DNA deamination (GO:0045006)3.87956333
32maturation of SSU-rRNA (GO:0030490)3.85836206
33DNA packaging (GO:0006323)3.76378324
34telomere maintenance via recombination (GO:0000722)3.75676245
35ribosomal small subunit biogenesis (GO:0042274)3.72610490
36microtubule depolymerization (GO:0007019)3.71504421
37spindle checkpoint (GO:0031577)3.69922699
38mitotic recombination (GO:0006312)3.69697497
39meiotic chromosome segregation (GO:0045132)3.69003008
40nuclear envelope disassembly (GO:0051081)3.65810894
41membrane disassembly (GO:0030397)3.65810894
42ribosomal large subunit biogenesis (GO:0042273)3.62954994
43regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.61804095
44spindle assembly checkpoint (GO:0071173)3.53846215
45regulation of chromosome segregation (GO:0051983)3.53827853
46translational elongation (GO:0006414)3.53290403
47establishment of integrated proviral latency (GO:0075713)3.52062314
48positive regulation of chromosome segregation (GO:0051984)3.51840021
49negative regulation of chromosome segregation (GO:0051985)3.51235189
50* histone exchange (GO:0043486)3.50341652
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.49365039
52negative regulation of mitotic sister chromatid segregation (GO:0033048)3.49365039
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.49365039
54negative regulation of sister chromatid segregation (GO:0033046)3.49365039
55mitotic spindle assembly checkpoint (GO:0007094)3.45705739
56translational initiation (GO:0006413)3.45681939
57chromosome segregation (GO:0007059)3.42502822
58telomere maintenance via telomere lengthening (GO:0010833)3.41436880
59formation of translation preinitiation complex (GO:0001731)3.41303256
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.40611194
61mitotic spindle checkpoint (GO:0071174)3.38884986
62regulation of mitotic metaphase/anaphase transition (GO:0030071)3.38474800
63mitotic sister chromatid cohesion (GO:0007064)3.38203883
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.35878734
65ribonucleoprotein complex biogenesis (GO:0022613)3.35355408
66DNA replication-dependent nucleosome organization (GO:0034723)3.35331274
67DNA replication-dependent nucleosome assembly (GO:0006335)3.35331274
68regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.31957971
69regulation of mitotic sister chromatid separation (GO:0010965)3.23653116
70regulation of mitotic sister chromatid segregation (GO:0033047)3.23653116
71regulation of sister chromatid segregation (GO:0033045)3.23653116
72SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23590243
73nuclear pore organization (GO:0006999)3.17427151
74regulation of nuclear cell cycle DNA replication (GO:0033262)3.16858360
75cotranslational protein targeting to membrane (GO:0006613)3.16392404
76ribosome biogenesis (GO:0042254)3.16177627
77spliceosomal snRNP assembly (GO:0000387)3.15152630
78cellular protein complex disassembly (GO:0043624)3.14187477
79protein targeting to ER (GO:0045047)3.12898225
80nucleobase biosynthetic process (GO:0046112)3.12619046
81positive regulation of mitotic sister chromatid separation (GO:1901970)3.11209965
82positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.11209965
83positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.11209965
84negative regulation of mitosis (GO:0045839)3.10386042
85* protein localization to chromosome (GO:0034502)3.10216614
86anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.10150667
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.10129244
88* chromatin assembly or disassembly (GO:0006333)3.06968581
89* mitotic cell cycle (GO:0000278)3.06369553
90regulation of telomere maintenance via telomerase (GO:0032210)3.06040525
91viral life cycle (GO:0019058)3.05356566
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03493895
93DNA topological change (GO:0006265)3.02434336
94rRNA processing (GO:0006364)3.01885874
95spindle assembly involved in mitosis (GO:0090307)3.01789940
96histone-serine phosphorylation (GO:0035404)3.00631568
97regulation of sister chromatid cohesion (GO:0007063)2.99790849
98spliceosomal complex assembly (GO:0000245)2.97718764
99DNA conformation change (GO:0071103)2.97416148
100protein complex localization (GO:0031503)2.97373188
101proteasome assembly (GO:0043248)2.97230050
102establishment of protein localization to endoplasmic reticulum (GO:0072599)2.96974560
103ribosome assembly (GO:0042255)2.96878934
104protein K6-linked ubiquitination (GO:0085020)2.96729742
105deoxyribonucleotide biosynthetic process (GO:0009263)2.95361654
106ventricular cardiac muscle cell development (GO:0055015)2.95025068
107* ATP-dependent chromatin remodeling (GO:0043044)2.94117563
108regulation of centrosome cycle (GO:0046605)2.93793077
109nuclear pore complex assembly (GO:0051292)2.93788508
110IMP biosynthetic process (GO:0006188)2.93717872
111regulation of double-strand break repair via homologous recombination (GO:0010569)2.93689194
112nuclear envelope organization (GO:0006998)2.93374334
113regulation of exit from mitosis (GO:0007096)2.93150546
114negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.92861093
115purine nucleobase biosynthetic process (GO:0009113)2.92689139
116regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92422975
117rRNA metabolic process (GO:0016072)2.92118643
118protein localization to endoplasmic reticulum (GO:0070972)2.91391831
119mitotic nuclear division (GO:0007067)2.90937280
120pore complex assembly (GO:0046931)2.88366778

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.37374966
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.10975041
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.17524261
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.12677712
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.02233095
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55100394
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.12953361
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94607167
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.82880334
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.72730206
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67510053
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.59755320
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.55001922
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50754003
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49445499
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.43934676
17* XRN2_22483619_ChIP-Seq_HELA_Human2.35739232
18AR_21909140_ChIP-Seq_LNCAP_Human2.33840163
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30496459
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26811924
21* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.17958155
22* VDR_23849224_ChIP-Seq_CD4+_Human2.14666479
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.13640712
24EGR1_19374776_ChIP-ChIP_THP-1_Human2.13118038
25* E2F1_21310950_ChIP-Seq_MCF-7_Human2.01429763
26FOXP3_21729870_ChIP-Seq_TREG_Human1.94388305
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93429402
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.88172023
29DCP1A_22483619_ChIP-Seq_HELA_Human1.87987135
30E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87723431
31SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.85233006
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81785527
33* TTF2_22483619_ChIP-Seq_HELA_Human1.81172875
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79124017
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76817705
36CIITA_25753668_ChIP-Seq_RAJI_Human1.71646520
37GABP_19822575_ChIP-Seq_HepG2_Human1.70016964
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.67939527
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65132972
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65109493
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.64199089
42ELK1_19687146_ChIP-ChIP_HELA_Human1.63683295
43* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63326923
44MYC_22102868_ChIP-Seq_BL_Human1.61895439
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.60116213
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59206680
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58208047
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.57692084
49ZNF263_19887448_ChIP-Seq_K562_Human1.49496722
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48482737
51* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48040389
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47663406
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.46027998
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40939211
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.40821386
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.39952018
57KDM5A_27292631_Chip-Seq_BREAST_Human1.39667193
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35011889
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29884196
60* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.26801693
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24852102
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24738549
63SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.23661896
64E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21043481
65* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19826556
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.17663037
67VDR_21846776_ChIP-Seq_THP-1_Human1.17650511
68* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16555122
69CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16007806
70SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11787690
71* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10966595
72* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10302973
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.10168042
74KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09593945
75* TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09493748
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08220739
77PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.07091194
78MYC_18940864_ChIP-ChIP_HL60_Human1.04616164
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03260370
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.02459383
81TFEB_21752829_ChIP-Seq_HELA_Human1.01257357
82SPI1_23547873_ChIP-Seq_NB4_Human0.98664599
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.96416690
84NOTCH1_21737748_ChIP-Seq_TLL_Human0.94164490
85CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93980926
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.92471538
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92328208
88* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91363107
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89307764
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88863243
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88529266
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.88303346
93ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85695995
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85038501
95TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83917979
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82183764
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81990115
98RBPJ_22232070_ChIP-Seq_NCS_Mouse0.81700991
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81629722
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.80847932
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.80780402
102TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80421755
103TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79680034
104CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.79433228
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.78714828
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.78315802
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.76957495
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76754780
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.75964466
110* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.74288268
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.71859875
112KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.71859875
113KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.71859875
114* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71255425

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.89602040
2* MP0003111_abnormal_nucleus_morphology4.91185972
3MP0010094_abnormal_chromosome_stability4.52946093
4* MP0004957_abnormal_blastocyst_morpholog4.16029349
5* MP0003077_abnormal_cell_cycle4.14152616
6MP0008057_abnormal_DNA_replication3.49665195
7MP0008058_abnormal_DNA_repair2.96865562
8MP0008007_abnormal_cellular_replicative2.87761592
9MP0008932_abnormal_embryonic_tissue2.66016378
10MP0000350_abnormal_cell_proliferation2.19454390
11MP0001730_embryonic_growth_arrest2.16387336
12MP0002396_abnormal_hematopoietic_system2.16287804
13MP0003123_paternal_imprinting1.98838366
14MP0000490_abnormal_crypts_of1.90355952
15MP0003786_premature_aging1.85867083
16MP0010307_abnormal_tumor_latency1.81227776
17MP0003718_maternal_effect1.77064267
18* MP0001672_abnormal_embryogenesis/_devel1.64286732
19* MP0005380_embryogenesis_phenotype1.64286732
20* MP0001697_abnormal_embryo_size1.63243793
21MP0009697_abnormal_copulation1.58959655
22MP0003567_abnormal_fetal_cardiomyocyte1.56557540
23MP0004808_abnormal_hematopoietic_stem1.54766778
24MP0008877_abnormal_DNA_methylation1.53817858
25* MP0002080_prenatal_lethality1.49942577
26* MP0000313_abnormal_cell_death1.49822920
27MP0010030_abnormal_orbit_morphology1.47831371
28MP0010352_gastrointestinal_tract_polyps1.45667726
29* MP0002085_abnormal_embryonic_tissue1.43967281
30MP0009333_abnormal_splenocyte_physiolog1.43599393
31MP0002019_abnormal_tumor_incidence1.43467494
32* MP0003984_embryonic_growth_retardation1.43016663
33MP0001346_abnormal_lacrimal_gland1.39933700
34* MP0002088_abnormal_embryonic_growth/wei1.39917498
35MP0005397_hematopoietic_system_phenotyp1.37100083
36MP0001545_abnormal_hematopoietic_system1.37100083
37MP0002877_abnormal_melanocyte_morpholog1.36274086
38MP0003763_abnormal_thymus_physiology1.32509676
39MP0004233_abnormal_muscle_weight1.30907922
40MP0005501_abnormal_skin_physiology1.30732666
41MP0000703_abnormal_thymus_morphology1.30680355
42* MP0002086_abnormal_extraembryonic_tissu1.29482577
43MP0003315_abnormal_perineum_morphology1.27756893
44MP0002697_abnormal_eye_size1.25730760
45MP0002398_abnormal_bone_marrow1.25246028
46MP0003705_abnormal_hypodermis_morpholog1.23781833
47MP0008789_abnormal_olfactory_epithelium1.23293004
48MP0004197_abnormal_fetal_growth/weight/1.22314468
49MP0002084_abnormal_developmental_patter1.21588440
50MP0002722_abnormal_immune_system1.19788358
51MP0002132_abnormal_respiratory_system1.18888762
52MP0005076_abnormal_cell_differentiation1.18760643
53MP0001293_anophthalmia1.13642510
54MP0006292_abnormal_olfactory_placode1.12695410
55MP0001661_extended_life_span1.11221422
56MP0003941_abnormal_skin_development1.11219360
57MP0005171_absent_coat_pigmentation1.10400475
58MP0000689_abnormal_spleen_morphology1.10068632
59MP0002210_abnormal_sex_determination1.09451975
60MP0006035_abnormal_mitochondrial_morpho1.08930078
61MP0003121_genomic_imprinting1.04245622
62MP0004185_abnormal_adipocyte_glucose1.01120566
63MP0005499_abnormal_olfactory_system1.00751764
64MP0005394_taste/olfaction_phenotype1.00751764
65MP0002102_abnormal_ear_morphology0.98413578
66MP0002234_abnormal_pharynx_morphology0.98041861
67MP0003699_abnormal_female_reproductive0.97603348
68MP0006054_spinal_hemorrhage0.96601035
69MP0000858_altered_metastatic_potential0.96407029
70MP0002653_abnormal_ependyma_morphology0.96105742
71MP0002429_abnormal_blood_cell0.95679054
72MP0009053_abnormal_anal_canal0.93723953
73MP0009278_abnormal_bone_marrow0.92607256
74MP0001145_abnormal_male_reproductive0.91579880
75MP0003186_abnormal_redox_activity0.87597660
76MP0009672_abnormal_birth_weight0.87001131
77MP0002161_abnormal_fertility/fecundity0.86684703
78MP0000716_abnormal_immune_system0.85538590
79MP0001119_abnormal_female_reproductive0.84987560
80MP0000428_abnormal_craniofacial_morphol0.84811947
81MP0002163_abnormal_gland_morphology0.82987795
82MP0003755_abnormal_palate_morphology0.81255453
83MP0005257_abnormal_intraocular_pressure0.80786038
84MP0003937_abnormal_limbs/digits/tail_de0.80496783
85MP0001929_abnormal_gametogenesis0.80046261
86MP0000653_abnormal_sex_gland0.79280994
87MP0005395_other_phenotype0.79015392
88MP0002111_abnormal_tail_morphology0.78095859
89MP0000566_synostosis0.77070410
90MP0002233_abnormal_nose_morphology0.77013220
91MP0000762_abnormal_tongue_morphology0.76067933
92MP0005408_hypopigmentation0.76050889
93MP0003698_abnormal_male_reproductive0.75949284
94MP0010234_abnormal_vibrissa_follicle0.75761536
95MP0003119_abnormal_digestive_system0.74239568
96MP0001800_abnormal_humoral_immune0.73282216
97MP0006036_abnormal_mitochondrial_physio0.72896326
98MP0003950_abnormal_plasma_membrane0.72534856
99MP0003656_abnormal_erythrocyte_physiolo0.71056241
100MP0009379_abnormal_foot_pigmentation0.70826651
101MP0002796_impaired_skin_barrier0.70516716
102MP0003890_abnormal_embryonic-extraembry0.70370148
103MP0001881_abnormal_mammary_gland0.70246119
104MP0005384_cellular_phenotype0.70100696
105MP0005621_abnormal_cell_physiology0.69877510
106MP0005671_abnormal_response_to0.68452273
107MP0002095_abnormal_skin_pigmentation0.67940789
108MP0002420_abnormal_adaptive_immunity0.67644819
109MP0000537_abnormal_urethra_morphology0.67566301
110MP0001819_abnormal_immune_cell0.66998769
111MP0002452_abnormal_antigen_presenting0.66717462
112MP0001286_abnormal_eye_development0.66557208
113MP0005174_abnormal_tail_pigmentation0.66532522
114* MP0003861_abnormal_nervous_system0.65778786
115MP0000685_abnormal_immune_system0.65243577
116MP0004147_increased_porphyrin_level0.65020036
117MP0001915_intracranial_hemorrhage0.64776452
118MP0001853_heart_inflammation0.64662486
119MP0005389_reproductive_system_phenotype0.64190375
120MP0001835_abnormal_antigen_presentation0.63730025
121* MP0003935_abnormal_craniofacial_develop0.63608873
122MP0003806_abnormal_nucleotide_metabolis0.63290063
123MP0002177_abnormal_outer_ear0.63242710
124MP0003453_abnormal_keratinocyte_physiol0.62994837
125MP0003385_abnormal_body_wall0.62718469
126MP0001919_abnormal_reproductive_system0.62031450
127MP0002405_respiratory_system_inflammati0.61943452
128MP0000358_abnormal_cell_content/0.61483250
129MP0000477_abnormal_intestine_morphology0.60931312
130MP0002938_white_spotting0.59802024
131MP0005023_abnormal_wound_healing0.59333574
132MP0002160_abnormal_reproductive_system0.59264195
133MP0002092_abnormal_eye_morphology0.58762163
134MP0000049_abnormal_middle_ear0.58519004
135MP0009703_decreased_birth_body0.57263771
136MP0002723_abnormal_immune_serum0.54782261
137MP0003136_yellow_coat_color0.54207030
138MP0000733_abnormal_muscle_development0.54066664

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.67864383
2Birth length less than 3rd percentile (HP:0003561)4.50291622
3Abnormality of cells of the erythroid lineage (HP:0012130)4.45064294
4Abnormal number of erythroid precursors (HP:0012131)4.39040130
5Chromsome breakage (HP:0040012)4.09645072
6Chromosomal breakage induced by crosslinking agents (HP:0003221)4.08999838
7Breast hypoplasia (HP:0003187)3.87190283
8Abnormality of the anterior horn cell (HP:0006802)3.50761599
9Degeneration of anterior horn cells (HP:0002398)3.50761599
10Patellar aplasia (HP:0006443)3.42208908
11Meckel diverticulum (HP:0002245)3.36376172
12Aplasia/Hypoplasia of the patella (HP:0006498)3.33483442
13Carpal bone hypoplasia (HP:0001498)3.32868702
14Oral leukoplakia (HP:0002745)3.21840947
15Abnormality of the preputium (HP:0100587)3.19194131
16Abnormality of the ileum (HP:0001549)3.17473616
17Pallor (HP:0000980)3.07100764
18Abnormality of chromosome stability (HP:0003220)3.03172666
19Macrocytic anemia (HP:0001972)2.96736649
20Selective tooth agenesis (HP:0001592)2.94904920
21Small intestinal stenosis (HP:0012848)2.93578149
22Duodenal stenosis (HP:0100867)2.93578149
23Colon cancer (HP:0003003)2.90852057
24Aplasia/Hypoplasia of the uvula (HP:0010293)2.90706354
25Aplastic anemia (HP:0001915)2.86926866
26Myelodysplasia (HP:0002863)2.86719013
27Absent thumb (HP:0009777)2.82174281
28Absent radius (HP:0003974)2.81814769
29Abnormal lung lobation (HP:0002101)2.71571213
30Impulsivity (HP:0100710)2.65574498
31Progressive muscle weakness (HP:0003323)2.63580483
32Rough bone trabeculation (HP:0100670)2.62833643
33Absent forearm bone (HP:0003953)2.61401525
34Aplasia involving forearm bones (HP:0009822)2.61401525
35Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58795214
36Increased hepatocellular lipid droplets (HP:0006565)2.55128259
37Broad distal phalanx of finger (HP:0009836)2.50475847
38Abnormal number of incisors (HP:0011064)2.49236007
39Triphalangeal thumb (HP:0001199)2.46844307
40Bone marrow hypocellularity (HP:0005528)2.46282658
41Ectopic kidney (HP:0000086)2.45640307
42Microvesicular hepatic steatosis (HP:0001414)2.44620999
43Abnormality of the heme biosynthetic pathway (HP:0010472)2.44486844
44Duplication of thumb phalanx (HP:0009942)2.42673563
45Medulloblastoma (HP:0002885)2.41973246
46Abnormality of the duodenum (HP:0002246)2.41233520
47Sloping forehead (HP:0000340)2.37760449
48Testicular atrophy (HP:0000029)2.36912020
49Short middle phalanx of the 5th finger (HP:0004220)2.36079146
50Duplicated collecting system (HP:0000081)2.35644443
51Neoplasm of the pancreas (HP:0002894)2.33012742
52Hypoplastic pelvis (HP:0008839)2.32109775
53Premature graying of hair (HP:0002216)2.31387955
54Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.30554674
55Lipid accumulation in hepatocytes (HP:0006561)2.29181733
5611 pairs of ribs (HP:0000878)2.29062750
57Horseshoe kidney (HP:0000085)2.28967862
58Abnormality of reticulocytes (HP:0004312)2.24299665
59Increased nuchal translucency (HP:0010880)2.24074395
60Tracheoesophageal fistula (HP:0002575)2.21295848
61Microretrognathia (HP:0000308)2.21215613
62Cortical dysplasia (HP:0002539)2.19433823
63Atresia of the external auditory canal (HP:0000413)2.17558544
64Progressive external ophthalmoplegia (HP:0000590)2.14323809
65Abnormality of the phalanges of the hallux (HP:0010057)2.13870536
66Cellular immunodeficiency (HP:0005374)2.13812536
67Trismus (HP:0000211)2.12135309
68Abnormal umbilical cord blood vessels (HP:0011403)2.12048803
69Single umbilical artery (HP:0001195)2.12048803
70Abnormality of the fetal cardiovascular system (HP:0010948)2.12048803
71Capillary hemangiomas (HP:0005306)2.12048531
72Rhabdomyosarcoma (HP:0002859)2.11792681
73Agnosia (HP:0010524)2.10797845
74Delayed epiphyseal ossification (HP:0002663)2.08254190
75Nephroblastoma (Wilms tumor) (HP:0002667)2.08065639
76Basal cell carcinoma (HP:0002671)2.04218758
77Missing ribs (HP:0000921)2.03417461
78Reduced antithrombin III activity (HP:0001976)2.00996868
79Cleft eyelid (HP:0000625)2.00644434
80Abnormality of the umbilical cord (HP:0010881)1.98480027
81Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97609122
82Clubbing of toes (HP:0100760)1.97395672
83Supernumerary spleens (HP:0009799)1.97031550
84Lymphoma (HP:0002665)1.96452490
85Abnormality of the renal collecting system (HP:0004742)1.96102565
86Short thumb (HP:0009778)1.95430626
87Abnormality of the carotid arteries (HP:0005344)1.93160755
88Neoplasm of the colon (HP:0100273)1.92892509
89Proximal placement of thumb (HP:0009623)1.92579811
90Rectovaginal fistula (HP:0000143)1.92094339
91Rectal fistula (HP:0100590)1.92094339
92Abnormality of glycolysis (HP:0004366)1.91225748
93Embryonal renal neoplasm (HP:0011794)1.91036528
94Increased serum pyruvate (HP:0003542)1.90891209
95Cafe-au-lait spot (HP:0000957)1.90831824
96Abnormality of DNA repair (HP:0003254)1.90287157
97Abnormal trabecular bone morphology (HP:0100671)1.90111230
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88035584
99Premature ovarian failure (HP:0008209)1.87662482
100Rib fusion (HP:0000902)1.85739103
101Squamous cell carcinoma (HP:0002860)1.83840195
102Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.82486356
103Decreased activity of mitochondrial respiratory chain (HP:0008972)1.82486356
104Deviation of the thumb (HP:0009603)1.81708535
105Ependymoma (HP:0002888)1.81128181
106Multiple enchondromatosis (HP:0005701)1.80840274
107Choanal atresia (HP:0000453)1.80430778
108Thrombocytosis (HP:0001894)1.79863917
109Atrophy/Degeneration involving motor neurons (HP:0007373)1.79427557
110Cerebral hypomyelination (HP:0006808)1.78654529
111Vaginal fistula (HP:0004320)1.75894023
112Pancytopenia (HP:0001876)1.73961809
113IgM deficiency (HP:0002850)1.73949737
114Arteriovenous malformation (HP:0100026)1.73675353
115Small epiphyses (HP:0010585)1.72765020
116Respiratory difficulties (HP:0002880)1.72394610
117Prominent nose (HP:0000448)1.72074878
118Aplasia/Hypoplasia of the sternum (HP:0006714)1.71564154
119Renal Fanconi syndrome (HP:0001994)1.70373781
120Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70218169
121Absent epiphyses (HP:0010577)1.70218169
122Combined immunodeficiency (HP:0005387)1.68252648
123Embryonal neoplasm (HP:0002898)1.67618799
124Entropion (HP:0000621)1.67558638
125High pitched voice (HP:0001620)1.66582456
126Abnormality of abdominal situs (HP:0011620)1.66005634
127Abdominal situs inversus (HP:0003363)1.66005634
128Hypoplasia of the radius (HP:0002984)1.65424669
129Increased serum lactate (HP:0002151)1.65357740
130Abnormalities of placenta or umbilical cord (HP:0001194)1.65062828
131Optic nerve coloboma (HP:0000588)1.64084814
132Increased CSF lactate (HP:0002490)1.63146708
133Short 4th metacarpal (HP:0010044)1.63069504
134Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63069504
135Leukopenia (HP:0001882)1.61681742
136Hypergonadotropic hypogonadism (HP:0000815)1.61091081
137Hypoplasia of the pons (HP:0012110)1.60869371
138Poikiloderma (HP:0001029)1.60656153
139Abnormality of chromosome segregation (HP:0002916)1.60543512
140Secondary amenorrhea (HP:0000869)1.60384105
141Slender long bone (HP:0003100)1.59868635
142Facial hemangioma (HP:0000329)1.59429965
143Volvulus (HP:0002580)1.59019395

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.11109380
2WEE13.94478192
3CDC73.77642185
4NEK23.57063688
5EIF2AK12.78529590
6TTK2.62946225
7SRPK12.59262527
8NME22.33027422
9VRK22.31254500
10BRSK22.24742716
11MKNK12.19423006
12PLK12.19271188
13PLK42.07572112
14TLK12.06010687
15MKNK21.87252494
16* AURKB1.84828326
17STK161.75296736
18TESK21.73904144
19VRK11.72888566
20BRSK11.69889415
21NEK11.68491743
22ACVR1B1.67805751
23SMG11.66128122
24STK101.62918668
25RPS6KA41.58892668
26CDK71.56862085
27STK41.56634910
28DYRK31.49155142
29CDK41.48959200
30CHEK21.48514915
31ATR1.47833479
32PLK31.46759951
33ZAK1.43444855
34CCNB11.41486443
35MAP3K81.39454657
36TSSK61.36313051
37EIF2AK31.33494688
38MAP3K101.33192533
39* AURKA1.31275578
40CDK121.28734910
41TAF11.27095194
42RPS6KB21.21744024
43EIF2AK21.14578981
44MAP4K11.13174861
45CHEK11.11858939
46ARAF1.09253263
47PASK1.05781694
48PBK1.03791213
49KDR1.03506037
50PAK41.03019085
51EEF2K0.93128695
52BRD40.92162732
53CLK10.90324613
54MAP3K90.88731083
55MST1R0.88444868
56EPHA20.88191065
57MELK0.87902310
58LATS20.87866036
59SCYL20.86964606
60ATM0.82315792
61PIM10.81370123
62CDK60.79767905
63CDK20.75717141
64NME10.73919089
65TGFBR10.70496320
66STK30.66715488
67MET0.66506015
68LRRK20.65704932
69PAK10.63350169
70CSNK2A10.62024995
71CDK80.60680293
72* CDK10.60364557
73PKN20.59745333
74BRAF0.57508907
75MAP3K110.56463778
76FLT30.56238394
77CSNK2A20.55257549
78MAP2K30.53880671
79ICK0.51646028
80RPS6KA50.51526495
81CDK11A0.50011564
82TRIB30.48872635
83BLK0.48746952
84ERBB40.48704139
85CDK150.47989849
86PIM20.47214018
87PDK20.46544831
88RAF10.46464331
89MARK30.45960326
90KSR20.45172171
91CDK180.44520303
92MST40.43721225
93STK38L0.42937057
94JAK30.42809029
95ZAP700.42437018
96BTK0.40769695
97PRKCI0.40483284
98NEK90.38245505
99IRAK30.38068097
100AKT20.37287268
101CDK140.36846124
102TESK10.34988295
103BMX0.34637830
104MTOR0.34159379
105TEC0.33811994
106ALK0.33770695
107IRAK40.32200703
108IKBKB0.31048457
109UHMK10.30282839
110GRK60.28705715
111ILK0.28300264
112TXK0.28171402
113TRIM280.27310376
114MOS0.27010616
115CSNK1E0.26946725
116PRKDC0.26399458
117MAPKAPK20.25049182
118CDK90.24689734
119PTK20.23988549
120TAOK20.23784410
121DYRK20.23496375
122PRPF4B0.23418847
123PNCK0.23341617
124NEK60.23271400
125LYN0.23109299
126STK240.22851795
127MAPK110.22354993
128CHUK0.21216074
129YES10.20381321
130MAPKAPK30.20317359

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.70912556
2Mismatch repair_Homo sapiens_hsa034303.90790748
3Ribosome_Homo sapiens_hsa030103.81816819
4Spliceosome_Homo sapiens_hsa030403.38764400
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.28697830
6Homologous recombination_Homo sapiens_hsa034403.14278705
7Base excision repair_Homo sapiens_hsa034103.07837490
8Cell cycle_Homo sapiens_hsa041103.06826473
9RNA polymerase_Homo sapiens_hsa030203.04081116
10RNA transport_Homo sapiens_hsa030132.94227446
11Proteasome_Homo sapiens_hsa030502.88172299
12Nucleotide excision repair_Homo sapiens_hsa034202.76037076
13Fanconi anemia pathway_Homo sapiens_hsa034602.52359914
14Pyrimidine metabolism_Homo sapiens_hsa002402.34731454
15One carbon pool by folate_Homo sapiens_hsa006702.31123631
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.10469080
17Non-homologous end-joining_Homo sapiens_hsa034502.03751044
18Basal transcription factors_Homo sapiens_hsa030221.96393821
19RNA degradation_Homo sapiens_hsa030181.92553921
20p53 signaling pathway_Homo sapiens_hsa041151.89819782
21mRNA surveillance pathway_Homo sapiens_hsa030151.79860954
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73973606
23Systemic lupus erythematosus_Homo sapiens_hsa053221.40721166
24Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37011686
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30090783
26Epstein-Barr virus infection_Homo sapiens_hsa051691.24101881
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.22428102
28Purine metabolism_Homo sapiens_hsa002301.19366756
29Oocyte meiosis_Homo sapiens_hsa041141.18000524
30Herpes simplex infection_Homo sapiens_hsa051681.15022368
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12437004
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08724808
33Pyruvate metabolism_Homo sapiens_hsa006201.01791067
34Primary immunodeficiency_Homo sapiens_hsa053401.00226472
35Viral carcinogenesis_Homo sapiens_hsa052030.98836326
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97523742
37Antigen processing and presentation_Homo sapiens_hsa046120.91454628
38HTLV-I infection_Homo sapiens_hsa051660.91439905
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90786003
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80307544
41MicroRNAs in cancer_Homo sapiens_hsa052060.75034313
42Small cell lung cancer_Homo sapiens_hsa052220.73313787
43Pentose phosphate pathway_Homo sapiens_hsa000300.72174852
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71651089
45Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.71631529
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68619033
47Alzheimers disease_Homo sapiens_hsa050100.67850336
48Vitamin B6 metabolism_Homo sapiens_hsa007500.67270677
49Fatty acid elongation_Homo sapiens_hsa000620.65623164
50Sulfur relay system_Homo sapiens_hsa041220.63345196
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63115079
52Huntingtons disease_Homo sapiens_hsa050160.62551807
53Measles_Homo sapiens_hsa051620.61322064
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.60769420
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.60500826
56Folate biosynthesis_Homo sapiens_hsa007900.60226564
57Apoptosis_Homo sapiens_hsa042100.60215595
58Thyroid cancer_Homo sapiens_hsa052160.59241966
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58883034
60Steroid biosynthesis_Homo sapiens_hsa001000.58717983
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.57191238
62Legionellosis_Homo sapiens_hsa051340.56725570
63Selenocompound metabolism_Homo sapiens_hsa004500.55244034
64Protein export_Homo sapiens_hsa030600.53882140
65Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53403885
66Hematopoietic cell lineage_Homo sapiens_hsa046400.52481631
67Cysteine and methionine metabolism_Homo sapiens_hsa002700.51435707
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.49915556
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47173228
70Fructose and mannose metabolism_Homo sapiens_hsa000510.46794408
71Galactose metabolism_Homo sapiens_hsa000520.46683794
72Hepatitis B_Homo sapiens_hsa051610.45779929
73Alcoholism_Homo sapiens_hsa050340.45564616
74Basal cell carcinoma_Homo sapiens_hsa052170.44567809
75Notch signaling pathway_Homo sapiens_hsa043300.44400443
76Metabolic pathways_Homo sapiens_hsa011000.44203572
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.43882158
78Shigellosis_Homo sapiens_hsa051310.43730180
79Bladder cancer_Homo sapiens_hsa052190.43116236
80Parkinsons disease_Homo sapiens_hsa050120.41880986
81Biosynthesis of amino acids_Homo sapiens_hsa012300.41229997
82Wnt signaling pathway_Homo sapiens_hsa043100.40445564
83Chronic myeloid leukemia_Homo sapiens_hsa052200.39417051
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39295759
85Viral myocarditis_Homo sapiens_hsa054160.38994245
86Hippo signaling pathway_Homo sapiens_hsa043900.38860598
87Colorectal cancer_Homo sapiens_hsa052100.38161764
88TGF-beta signaling pathway_Homo sapiens_hsa043500.37860920
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37306978
90Influenza A_Homo sapiens_hsa051640.35260420
91Arginine and proline metabolism_Homo sapiens_hsa003300.34883267
92Asthma_Homo sapiens_hsa053100.34091963
93Glutathione metabolism_Homo sapiens_hsa004800.32197234
94Lysine degradation_Homo sapiens_hsa003100.31966058
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31700244
96Cardiac muscle contraction_Homo sapiens_hsa042600.30921073
97Pathways in cancer_Homo sapiens_hsa052000.30564737
98Graft-versus-host disease_Homo sapiens_hsa053320.30085948
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29255203
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28667548
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28600413
102Arginine biosynthesis_Homo sapiens_hsa002200.28495605
103Allograft rejection_Homo sapiens_hsa053300.28315722
104Acute myeloid leukemia_Homo sapiens_hsa052210.27457773
105Leishmaniasis_Homo sapiens_hsa051400.26052724
106N-Glycan biosynthesis_Homo sapiens_hsa005100.25435472
107Cyanoamino acid metabolism_Homo sapiens_hsa004600.24662060
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24575183
109Melanoma_Homo sapiens_hsa052180.24167137
110HIF-1 signaling pathway_Homo sapiens_hsa040660.24059502
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22920086
112Sulfur metabolism_Homo sapiens_hsa009200.22727244
113Carbon metabolism_Homo sapiens_hsa012000.20998965
114FoxO signaling pathway_Homo sapiens_hsa040680.20287384
115Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20115584
116B cell receptor signaling pathway_Homo sapiens_hsa046620.19780048
117Hedgehog signaling pathway_Homo sapiens_hsa043400.19441284
118Prostate cancer_Homo sapiens_hsa052150.19139165
119Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.18883125
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.18500812
121Oxidative phosphorylation_Homo sapiens_hsa001900.18244890
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17450609
123Adherens junction_Homo sapiens_hsa045200.15879435
124Non-small cell lung cancer_Homo sapiens_hsa052230.15641420
125T cell receptor signaling pathway_Homo sapiens_hsa046600.14775468
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14429629
127Pancreatic cancer_Homo sapiens_hsa052120.14344330
128Arachidonic acid metabolism_Homo sapiens_hsa005900.13791370
129Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10850270

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