CELF4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.82967759
2neuron cell-cell adhesion (GO:0007158)5.70810735
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.64247282
4synaptic vesicle exocytosis (GO:0016079)5.37353978
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.32716640
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.08798803
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.07468403
8regulation of glutamate receptor signaling pathway (GO:1900449)4.87500299
9locomotory exploration behavior (GO:0035641)4.86728934
10protein localization to synapse (GO:0035418)4.79536672
11ionotropic glutamate receptor signaling pathway (GO:0035235)4.66848311
12synaptic vesicle maturation (GO:0016188)4.65576108
13pyrimidine nucleobase catabolic process (GO:0006208)4.55624594
14glutamate secretion (GO:0014047)4.54582993
15regulation of synaptic vesicle exocytosis (GO:2000300)4.47027197
16behavioral response to nicotine (GO:0035095)4.36602525
17neuron recognition (GO:0008038)4.36421065
18neurotransmitter secretion (GO:0007269)4.33733075
19glutamate receptor signaling pathway (GO:0007215)4.32083313
20exploration behavior (GO:0035640)4.30650613
21regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.26631403
22dendritic spine morphogenesis (GO:0060997)4.25256753
23neuronal action potential propagation (GO:0019227)4.08842670
24layer formation in cerebral cortex (GO:0021819)4.07616861
25regulation of long-term neuronal synaptic plasticity (GO:0048169)4.07180858
26neuron-neuron synaptic transmission (GO:0007270)4.01095230
27regulation of synaptic vesicle transport (GO:1902803)3.99884515
28synaptic transmission, glutamatergic (GO:0035249)3.97659049
29regulation of neuronal synaptic plasticity (GO:0048168)3.88980349
30gamma-aminobutyric acid signaling pathway (GO:0007214)3.88431162
31neurofilament cytoskeleton organization (GO:0060052)3.85126299
32membrane depolarization during action potential (GO:0086010)3.81457818
33nucleobase catabolic process (GO:0046113)3.79716637
34regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.79440912
35proline transport (GO:0015824)3.78793507
36response to histamine (GO:0034776)3.77107292
37neurotransmitter transport (GO:0006836)3.75560826
38axonal fasciculation (GO:0007413)3.72264595
39long-term memory (GO:0007616)3.70868032
40transmission of nerve impulse (GO:0019226)3.69601923
41regulation of synapse structural plasticity (GO:0051823)3.66469222
42mating behavior (GO:0007617)3.62437307
43synaptic vesicle docking involved in exocytosis (GO:0016081)3.60491253
44presynaptic membrane assembly (GO:0097105)3.58890226
45gamma-aminobutyric acid transport (GO:0015812)3.57601578
46* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.56871814
47establishment of mitochondrion localization (GO:0051654)3.56622325
48postsynaptic membrane organization (GO:0001941)3.55663799
49dopamine biosynthetic process (GO:0042416)3.54644201
50neurotransmitter-gated ion channel clustering (GO:0072578)3.54411438
51regulation of glutamate secretion (GO:0014048)3.54370086
52regulation of vesicle fusion (GO:0031338)3.53562466
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.53290600
54regulation of neurotransmitter levels (GO:0001505)3.52848579
55positive regulation of membrane potential (GO:0045838)3.52635585
56positive regulation of synapse assembly (GO:0051965)3.50679125
57regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.48954635
58* regulation of postsynaptic membrane potential (GO:0060078)3.48584195
59synaptic vesicle endocytosis (GO:0048488)3.48429309
60serotonin metabolic process (GO:0042428)3.43060835
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.41895465
62regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.39251498
63neuronal action potential (GO:0019228)3.36820173
64positive regulation of synapse maturation (GO:0090129)3.36656196
65synapse assembly (GO:0007416)3.34508966
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.32059616
67presynaptic membrane organization (GO:0097090)3.31036018
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30992780
69positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30884650
70cell migration in hindbrain (GO:0021535)3.28180562
71regulation of dendritic spine morphogenesis (GO:0061001)3.27242051
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25741981
73behavioral response to cocaine (GO:0048148)3.20851695
74behavioral defense response (GO:0002209)3.20814519
75behavioral fear response (GO:0001662)3.20814519
76intraspecies interaction between organisms (GO:0051703)3.20776564
77social behavior (GO:0035176)3.20776564
78long-term synaptic potentiation (GO:0060291)3.20330661
79prepulse inhibition (GO:0060134)3.19136214
80negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.18955344
81membrane hyperpolarization (GO:0060081)3.18474526
82response to amphetamine (GO:0001975)3.18098687
83positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17723863
84neuromuscular synaptic transmission (GO:0007274)3.16986712
85regulation of neurotransmitter secretion (GO:0046928)3.16969021
86auditory behavior (GO:0031223)3.15376446
87regulation of synaptic plasticity (GO:0048167)3.14098894
88fear response (GO:0042596)3.12984476
89regulation of protein kinase A signaling (GO:0010738)3.12645986
90activation of protein kinase A activity (GO:0034199)3.11691324
91adult walking behavior (GO:0007628)3.10341961
92startle response (GO:0001964)3.09193202
93positive regulation of potassium ion transmembrane transport (GO:1901381)3.07216819
94establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.07166871
95mitochondrion transport along microtubule (GO:0047497)3.07166871
96* membrane depolarization (GO:0051899)3.06009257
97mechanosensory behavior (GO:0007638)3.04906078
98neuromuscular process controlling posture (GO:0050884)3.04549642
99primary amino compound metabolic process (GO:1901160)3.04477621
100learning (GO:0007612)3.04071009
101detection of calcium ion (GO:0005513)3.03981647
102negative regulation of microtubule polymerization (GO:0031115)3.03724825
103positive regulation of neurotransmitter transport (GO:0051590)3.03200679
104G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02466076
105positive regulation of dendritic spine development (GO:0060999)2.99845055
106cerebellar Purkinje cell differentiation (GO:0021702)2.99793233
107regulation of synapse maturation (GO:0090128)2.99546183
108regulation of neurotransmitter transport (GO:0051588)2.98968435
109synaptic vesicle transport (GO:0048489)2.98480403
110establishment of synaptic vesicle localization (GO:0097480)2.98480403
111regulation of dopamine secretion (GO:0014059)2.98193523
112synaptic transmission (GO:0007268)2.98075865
113synapse organization (GO:0050808)2.97984433
114regulation of voltage-gated calcium channel activity (GO:1901385)2.97476383
115positive regulation of neurotransmitter secretion (GO:0001956)2.97286647
116central nervous system myelination (GO:0022010)2.97153797
117axon ensheathment in central nervous system (GO:0032291)2.97153797
118synaptic transmission, dopaminergic (GO:0001963)2.97109352
119neuronal ion channel clustering (GO:0045161)2.97058545
120positive regulation of dendritic spine morphogenesis (GO:0061003)2.96566558
121central nervous system projection neuron axonogenesis (GO:0021952)2.96553772
122regulation of respiratory system process (GO:0044065)2.95936799
123response to auditory stimulus (GO:0010996)2.95436826
124righting reflex (GO:0060013)2.94558381
125cellular potassium ion homeostasis (GO:0030007)2.94104044
126regulation of dendritic spine development (GO:0060998)2.93498784
127innervation (GO:0060384)2.93341615
128dendrite morphogenesis (GO:0048813)2.93263798
129response to insecticide (GO:0017085)2.89323910
130adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.88649598
131adult behavior (GO:0030534)2.86736472

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.78725404
2GBX2_23144817_ChIP-Seq_PC3_Human3.73595790
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18401173
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16413637
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07857851
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.70646568
7SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.68390102
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68197314
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68197314
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.66888647
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.66434971
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59278680
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53997210
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46200880
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43930038
16TAF15_26573619_Chip-Seq_HEK293_Human2.43852651
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.41734620
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40971145
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.29130309
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22055588
21CTBP2_25329375_ChIP-Seq_LNCAP_Human2.20063003
22* EZH2_27294783_Chip-Seq_ESCs_Mouse2.18291013
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.14048744
24* RNF2_27304074_Chip-Seq_ESCs_Mouse2.10701217
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.09355878
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.08892817
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06697144
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03835654
29* DROSHA_22980978_ChIP-Seq_HELA_Human2.03060651
30AR_21572438_ChIP-Seq_LNCaP_Human1.94864301
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91577716
32ZNF274_21170338_ChIP-Seq_K562_Hela1.80789619
33* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.78597702
34SMAD4_21799915_ChIP-Seq_A2780_Human1.70360083
35CBX2_27304074_Chip-Seq_ESCs_Mouse1.67297567
36* P300_19829295_ChIP-Seq_ESCs_Human1.64369081
37ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63257674
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59628015
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58038060
40IGF1R_20145208_ChIP-Seq_DFB_Human1.57537002
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55109811
42* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49670955
43* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.48893204
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.46116550
45RNF2_27304074_Chip-Seq_NSC_Mouse1.43376207
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42546728
47* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41559278
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40997134
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39929549
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39106636
51FUS_26573619_Chip-Seq_HEK293_Human1.37807605
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37485750
53* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36495371
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.35472540
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.31610108
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29680846
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.29345926
58* AR_25329375_ChIP-Seq_VCAP_Human1.29006837
59* RING1B_27294783_Chip-Seq_ESCs_Mouse1.27465981
60VDR_22108803_ChIP-Seq_LS180_Human1.26343791
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25285483
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22713343
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22356815
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20947586
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20880560
66* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17144184
67STAT3_23295773_ChIP-Seq_U87_Human1.16285895
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11379493
69* RUNX2_22187159_ChIP-Seq_PCA_Human1.10254992
70ER_23166858_ChIP-Seq_MCF-7_Human1.09741595
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.09151350
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09008753
73* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08763752
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08479798
75AR_19668381_ChIP-Seq_PC3_Human1.07468199
76JUN_21703547_ChIP-Seq_K562_Human1.07004974
77TCF4_23295773_ChIP-Seq_U87_Human1.06555220
78* RING1B_27294783_Chip-Seq_NPCs_Mouse1.03747541
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.03154601
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.02899812
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02764412
82FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02405804
83* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00959393
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.00857119
85TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00351612
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00082039
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99896042
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99896042
89GATA1_26923725_Chip-Seq_HPCs_Mouse0.99538156
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99299158
91BCAT_22108803_ChIP-Seq_LS180_Human0.98690620
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98182151
93ARNT_22903824_ChIP-Seq_MCF-7_Human0.98014069
94NANOG_18555785_Chip-Seq_ESCs_Mouse0.97817871
95RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97247845
96YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95639079
97TP53_18474530_ChIP-ChIP_U2OS_Human0.94973747
98* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91994355
99SMAD3_21741376_ChIP-Seq_ESCs_Human0.91903761
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90874439
101AHR_22903824_ChIP-Seq_MCF-7_Human0.90530294
102BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89605193
103WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89423879
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88703275
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88680520
106TP53_16413492_ChIP-PET_HCT116_Human0.88516672
107* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.88305486
108* CBP_20019798_ChIP-Seq_JUKART_Human0.88305486
109* TAL1_26923725_Chip-Seq_HPCs_Mouse0.88019734
110KDM2B_26808549_Chip-Seq_REH_Human0.86197840
111EWS_26573619_Chip-Seq_HEK293_Human0.83775446
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.82693895
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.81709598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.46225816
2MP0004859_abnormal_synaptic_plasticity5.29036094
3MP0003635_abnormal_synaptic_transmissio3.95716185
4MP0009745_abnormal_behavioral_response3.38684937
5MP0002063_abnormal_learning/memory/cond3.18525939
6MP0005423_abnormal_somatic_nervous3.13294015
7MP0004270_analgesia3.12456668
8* MP0002064_seizures3.06930767
9MP0009046_muscle_twitch3.06632542
10MP0001968_abnormal_touch/_nociception2.98299790
11MP0006276_abnormal_autonomic_nervous2.94345670
12MP0002572_abnormal_emotion/affect_behav2.90363984
13MP0002272_abnormal_nervous_system2.53228784
14MP0002822_catalepsy2.52586479
15MP0001486_abnormal_startle_reflex2.50561441
16MP0002734_abnormal_mechanical_nocicepti2.50423485
17MP0001440_abnormal_grooming_behavior2.49731697
18MP0001501_abnormal_sleep_pattern2.47757148
19MP0001529_abnormal_vocalization2.44622357
20MP0002736_abnormal_nociception_after2.27753040
21MP0002735_abnormal_chemical_nociception2.18678857
22MP0002733_abnormal_thermal_nociception2.12177445
23MP0002067_abnormal_sensory_capabilities2.05819894
24MP0003122_maternal_imprinting2.04478143
25MP0001905_abnormal_dopamine_level2.01793765
26MP0002184_abnormal_innervation2.01026882
27MP0004924_abnormal_behavior2.00748932
28MP0005386_behavior/neurological_phenoty2.00748932
29MP0001970_abnormal_pain_threshold1.97996468
30MP0000778_abnormal_nervous_system1.97211644
31MP0002557_abnormal_social/conspecific_i1.89345048
32MP0005645_abnormal_hypothalamus_physiol1.75423072
33MP0001984_abnormal_olfaction1.71369988
34MP0008877_abnormal_DNA_methylation1.64847137
35MP0002909_abnormal_adrenal_gland1.64409585
36MP0001188_hyperpigmentation1.56252675
37MP0004142_abnormal_muscle_tone1.55687506
38MP0005646_abnormal_pituitary_gland1.54877228
39MP0004811_abnormal_neuron_physiology1.54521152
40MP0008569_lethality_at_weaning1.50740284
41MP0003329_amyloid_beta_deposits1.50738393
42MP0000955_abnormal_spinal_cord1.39979283
43* MP0002066_abnormal_motor_capabilities/c1.39676281
44MP0002882_abnormal_neuron_morphology1.38916416
45MP0000566_synostosis1.36970721
46MP0001502_abnormal_circadian_rhythm1.36936185
47MP0003879_abnormal_hair_cell1.34552183
48MP0003787_abnormal_imprinting1.26157971
49MP0004858_abnormal_nervous_system1.25063657
50MP0004133_heterotaxia1.23473287
51MP0004742_abnormal_vestibular_system1.20961736
52MP0002837_dystrophic_cardiac_calcinosis1.20886119
53MP0009780_abnormal_chondrocyte_physiolo1.18987226
54MP0010386_abnormal_urinary_bladder1.14862946
55MP0008872_abnormal_physiological_respon1.13221045
56MP0000751_myopathy1.13117890
57MP0005551_abnormal_eye_electrophysiolog1.10883027
58MP0002152_abnormal_brain_morphology1.10669303
59MP0003890_abnormal_embryonic-extraembry1.06701478
60MP0003633_abnormal_nervous_system1.01096032
61MP0004885_abnormal_endolymph1.00850754
62MP0005535_abnormal_body_temperature0.99179605
63MP0000631_abnormal_neuroendocrine_gland0.98896584
64MP0002069_abnormal_eating/drinking_beha0.97407863
65MP0004145_abnormal_muscle_electrophysio0.96992777
66MP0005409_darkened_coat_color0.95671960
67MP0003283_abnormal_digestive_organ0.93975289
68MP0005394_taste/olfaction_phenotype0.93131183
69MP0005499_abnormal_olfactory_system0.93131183
70MP0003631_nervous_system_phenotype0.92869798
71MP0002653_abnormal_ependyma_morphology0.92385252
72MP0001986_abnormal_taste_sensitivity0.91977834
73MP0002229_neurodegeneration0.91864981
74MP0000569_abnormal_digit_pigmentation0.91514105
75MP0006072_abnormal_retinal_apoptosis0.90494883
76MP0002876_abnormal_thyroid_physiology0.88881671
77MP0002638_abnormal_pupillary_reflex0.87492619
78MP0001963_abnormal_hearing_physiology0.86773272
79MP0002752_abnormal_somatic_nervous0.86430459
80MP0003938_abnormal_ear_development0.84438536
81MP0004085_abnormal_heartbeat0.83462012
82MP0006292_abnormal_olfactory_placode0.83253127
83MP0003121_genomic_imprinting0.82397056
84MP0000013_abnormal_adipose_tissue0.81237445
85MP0008874_decreased_physiological_sensi0.80520693
86MP0001664_abnormal_digestion0.77285079
87MP0005187_abnormal_penis_morphology0.76829905
88MP0002090_abnormal_vision0.74881402
89MP0003634_abnormal_glial_cell0.71456480
90MP0009379_abnormal_foot_pigmentation0.69738797
91MP0001177_atelectasis0.69322306
92MP0003632_abnormal_nervous_system0.69234565
93MP0005195_abnormal_posterior_eye0.68995779
94MP0002102_abnormal_ear_morphology0.66858604
95MP0002928_abnormal_bile_duct0.64305565
96MP0005379_endocrine/exocrine_gland_phen0.63326887
97MP0000026_abnormal_inner_ear0.63205212
98MP0004130_abnormal_muscle_cell0.62758586
99MP0001943_abnormal_respiration0.61524516
100MP0003137_abnormal_impulse_conducting0.60971699
101MP0000049_abnormal_middle_ear0.60375655
102MP0004215_abnormal_myocardial_fiber0.60185756
103MP0003011_delayed_dark_adaptation0.59853876
104MP0003861_abnormal_nervous_system0.59714770
105MP0000920_abnormal_myelination0.58757682
106MP0003123_paternal_imprinting0.58384072
107MP0000604_amyloidosis0.57099711
108MP0008961_abnormal_basal_metabolism0.56867181
109MP0002751_abnormal_autonomic_nervous0.56758061
110MP0001485_abnormal_pinna_reflex0.56104095
111MP0004484_altered_response_of0.52797939
112MP0002082_postnatal_lethality0.52330505
113MP0010770_preweaning_lethality0.52330505
114MP0005253_abnormal_eye_physiology0.51826443
115MP0010769_abnormal_survival0.51001848
116MP0003690_abnormal_glial_cell0.50193436

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.40125018
2Myokymia (HP:0002411)5.91229523
3Focal seizures (HP:0007359)5.69805714
4Visual hallucinations (HP:0002367)5.61947247
5Atonic seizures (HP:0010819)4.71006754
6Epileptic encephalopathy (HP:0200134)4.51928540
7Absence seizures (HP:0002121)4.43257150
8Progressive cerebellar ataxia (HP:0002073)4.41396381
9Febrile seizures (HP:0002373)4.35651209
10Limb dystonia (HP:0002451)4.17256929
11Dialeptic seizures (HP:0011146)4.07468706
12Generalized tonic-clonic seizures (HP:0002069)3.94988019
13Broad-based gait (HP:0002136)3.72732728
14Hyperventilation (HP:0002883)3.46147722
15Amblyopia (HP:0000646)3.22248450
16Supranuclear gaze palsy (HP:0000605)3.18519990
17Anxiety (HP:0000739)3.06528039
18Polyphagia (HP:0002591)3.06050013
19Mutism (HP:0002300)3.05056609
20Action tremor (HP:0002345)2.99843178
21Progressive inability to walk (HP:0002505)2.98894847
22Truncal ataxia (HP:0002078)2.97205453
23Abnormal eating behavior (HP:0100738)2.96144251
24Excessive salivation (HP:0003781)2.93389520
25Drooling (HP:0002307)2.93389520
26Poor eye contact (HP:0000817)2.93071073
27Cerebral inclusion bodies (HP:0100314)2.84144047
28Gaze-evoked nystagmus (HP:0000640)2.82994319
29Impaired vibration sensation in the lower limbs (HP:0002166)2.76867399
30Depression (HP:0000716)2.75806773
31Dysdiadochokinesis (HP:0002075)2.70845533
32Dysmetria (HP:0001310)2.65111234
33Papilledema (HP:0001085)2.60821919
34Impaired social interactions (HP:0000735)2.60186205
35Abnormal social behavior (HP:0012433)2.60186205
36Ankle clonus (HP:0011448)2.58621371
37Failure to thrive in infancy (HP:0001531)2.58357114
38Neurofibrillary tangles (HP:0002185)2.56940646
39Pheochromocytoma (HP:0002666)2.56890057
40Morphological abnormality of the pyramidal tract (HP:0002062)2.52901994
41Epileptiform EEG discharges (HP:0011182)2.52158873
42Sleep apnea (HP:0010535)2.50838007
43Agitation (HP:0000713)2.48116226
44Gait imbalance (HP:0002141)2.47223670
45Hemiparesis (HP:0001269)2.46767687
46EEG with generalized epileptiform discharges (HP:0011198)2.45433548
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.41774186
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.41774186
49Type II lissencephaly (HP:0007260)2.39312241
50Fetal akinesia sequence (HP:0001989)2.36840912
51Lissencephaly (HP:0001339)2.36537741
52Urinary bladder sphincter dysfunction (HP:0002839)2.35376876
53Diplopia (HP:0000651)2.33454882
54Abnormality of binocular vision (HP:0011514)2.33454882
55Molar tooth sign on MRI (HP:0002419)2.32447693
56Abnormality of midbrain morphology (HP:0002418)2.32447693
57Inability to walk (HP:0002540)2.32144875
58Absent speech (HP:0001344)2.31555014
59Congenital stationary night blindness (HP:0007642)2.28556340
60Abnormality of the corticospinal tract (HP:0002492)2.28430469
61Hypsarrhythmia (HP:0002521)2.26490507
62Neuroendocrine neoplasm (HP:0100634)2.26116412
63Genetic anticipation (HP:0003743)2.23816560
64Acute necrotizing encephalopathy (HP:0006965)2.23079650
65Amyotrophic lateral sclerosis (HP:0007354)2.22968885
66Hypoventilation (HP:0002791)2.22435532
67Esotropia (HP:0000565)2.19913932
68Urinary urgency (HP:0000012)2.19322564
69Pancreatic fibrosis (HP:0100732)2.17652984
70Nephronophthisis (HP:0000090)2.17535868
71Insidious onset (HP:0003587)2.17118929
72Termporal pattern (HP:0011008)2.17118929
73Spastic tetraplegia (HP:0002510)2.16976361
74Bradykinesia (HP:0002067)2.16972136
75Progressive macrocephaly (HP:0004481)2.16421967
76Impaired smooth pursuit (HP:0007772)2.15018011
77Protruding tongue (HP:0010808)2.14389419
78Dynein arm defect of respiratory motile cilia (HP:0012255)2.14003135
79Absent/shortened dynein arms (HP:0200106)2.14003135
80Spastic gait (HP:0002064)2.13870969
81Postural instability (HP:0002172)2.13576953
82Psychosis (HP:0000709)2.13525961
83Abnormal ciliary motility (HP:0012262)2.13441988
84Scanning speech (HP:0002168)2.13075966
85Stereotypic behavior (HP:0000733)2.11811658
86Delusions (HP:0000746)2.09857916
87Pachygyria (HP:0001302)2.09532206
88Torticollis (HP:0000473)2.09453872
89Abnormal hair whorl (HP:0010721)2.09236106
90Pancreatic cysts (HP:0001737)2.08901951
91Generalized myoclonic seizures (HP:0002123)2.08384459
92Focal dystonia (HP:0004373)2.06582970
93Aplasia/Hypoplasia of the brainstem (HP:0007362)2.04893985
94Hypoplasia of the brainstem (HP:0002365)2.04893985
95True hermaphroditism (HP:0010459)2.04647537
96Specific learning disability (HP:0001328)2.03825235
97Retinal dysplasia (HP:0007973)2.03397554
98Hemiplegia (HP:0002301)2.01496753
99Abnormality of salivation (HP:0100755)2.00739906
100Hyperthyroidism (HP:0000836)2.00260467
101Abnormality of the labia minora (HP:0012880)1.98861234
102Poor suck (HP:0002033)1.98675605
103Congenital primary aphakia (HP:0007707)1.98421465
104Abnormal mitochondria in muscle tissue (HP:0008316)1.97449967
105Blue irides (HP:0000635)1.97191135
106Status epilepticus (HP:0002133)1.95952338
107Abnormality of ocular smooth pursuit (HP:0000617)1.94370744
108Medial flaring of the eyebrow (HP:0010747)1.94103999
109Incomplete penetrance (HP:0003829)1.93550592
110Exotropia (HP:0000577)1.93382432
111Ulnar claw (HP:0001178)1.90102992
112Gait ataxia (HP:0002066)1.87249245
113Genital tract atresia (HP:0001827)1.84938943
114Hypothermia (HP:0002045)1.83652454
115Narrow nasal bridge (HP:0000446)1.82732942
116Pendular nystagmus (HP:0012043)1.82550155
117Vaginal atresia (HP:0000148)1.82544603
118Craniofacial dystonia (HP:0012179)1.82485591
119Nephrogenic diabetes insipidus (HP:0009806)1.81232525
120Inappropriate behavior (HP:0000719)1.80573104
121Akinesia (HP:0002304)1.80048122
122Abnormal respiratory motile cilium morphology (HP:0005938)1.78831715
123Abnormal respiratory epithelium morphology (HP:0012253)1.78831715
124Cerebral hypomyelination (HP:0006808)1.78133187
125Ventricular fibrillation (HP:0001663)1.78075655
126Prolonged QT interval (HP:0001657)1.76788664
127Abnormal EKG (HP:0003115)1.76786886
128Intention tremor (HP:0002080)1.76512394
129Dyskinesia (HP:0100660)1.76127318
130Muscular hypotonia of the trunk (HP:0008936)1.72507909
131Shawl scrotum (HP:0000049)1.67678192
132Intellectual disability, severe (HP:0010864)1.67374638
133Hypoplasia of the corpus callosum (HP:0002079)1.67282955
134Myotonia (HP:0002486)1.62230984

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.24891330
2MAP3K93.53480891
3MARK13.52279569
4EPHA43.50583173
5MAP3K43.20338411
6PNCK3.18412578
7MAP3K123.10768276
8MAP2K72.81874180
9MINK12.56723968
10NTRK22.46309072
11CASK2.43694555
12MAP2K42.12548128
13PINK12.08423229
14SIK21.93944065
15TNIK1.85024639
16RIPK41.82099770
17DAPK21.81215094
18MAPK131.80821594
19GRK51.76978880
20PAK61.72498713
21ARAF1.68301865
22PLK21.68072095
23NTRK11.67185663
24KSR11.56889379
25KSR21.54341952
26CDK51.46773484
27UHMK11.39537975
28DAPK11.32577816
29FRK1.28254883
30CDK191.24896703
31GRK11.21275638
32FES1.20386854
33CAMK2A1.20088037
34PRKCG1.19847176
35NME11.19721819
36CAMKK11.13870541
37CSNK1G21.05823938
38MAP3K131.04543419
39CAMK2B1.01886184
40LATS20.99763444
41GRK70.95510678
42CDK180.94168997
43PHKG20.93377359
44PHKG10.93377359
45CAMKK20.93094304
46CDK140.92564063
47FGR0.91290997
48CDK150.90878979
49BMPR20.84917264
50OXSR10.84899430
51PRPF4B0.83987275
52DYRK1A0.83232088
53PAK30.82660079
54PRKD30.81539590
55CDK11A0.79608765
56CAMK1G0.79453543
57SIK30.79287970
58PTK2B0.77413119
59BMPR1B0.77286615
60CAMK10.77252016
61STK110.76285574
62MAP3K110.75286791
63STK380.74758740
64ADRBK20.74222221
65MAP3K20.73873768
66TYRO30.72658357
67MAPKAPK50.70253246
68CSNK1G30.69924495
69MAP4K20.68704658
70BCR0.67836533
71WNK30.65336324
72CAMK2D0.64999614
73RAF10.64978155
74SGK2230.63828287
75SGK4940.63828287
76INSRR0.63128769
77RET0.62689752
78PRKCE0.60556985
79SGK10.59014367
80CAMK40.56323020
81SGK30.55463874
82TLK10.55025844
83MARK20.54878411
84ADRBK10.54874250
85MAP3K60.54672813
86TNK20.54084715
87CAMK2G0.52478723
88CSNK1A1L0.51652504
89PRKCZ0.50030397
90TAOK30.49358689
91PRKG10.48252085
92SGK20.45341042
93TRIM280.44900636
94MUSK0.44538313
95PKN10.44450721
96LIMK10.43031402
97PRKCH0.41361912
98BRAF0.41167695
99ROCK20.40831000
100FER0.40730587
101RPS6KA30.40143392
102FGFR20.39669263
103DYRK20.39574924
104MAP2K10.39546820
105PRKACA0.38735424
106FYN0.38551887
107STK390.38397371
108MAP3K10.37950330
109CSNK1D0.37816987
110GRK60.37639921
111PRKCA0.37585393
112MAPK40.37091348
113CSNK1A10.36608023
114CSNK1G10.35766238
115CSNK1E0.35508827
116MAPK100.35473360
117WNK40.34651869
118ALK0.34619933
119PRKCB0.34300471
120PRKAA10.32811251
121ERBB30.32379477
122MAPK120.32358283
123PRKACB0.32172124
124MAPK150.28839330
125PRKACG0.28538674
126MAPK80.26541248

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.33173959
2Synaptic vesicle cycle_Homo sapiens_hsa047213.40385908
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.88060789
4GABAergic synapse_Homo sapiens_hsa047272.81202333
5Long-term potentiation_Homo sapiens_hsa047202.59375315
6Amphetamine addiction_Homo sapiens_hsa050312.58712820
7Glutamatergic synapse_Homo sapiens_hsa047242.53547019
8Olfactory transduction_Homo sapiens_hsa047402.53055928
9Circadian entrainment_Homo sapiens_hsa047132.52868253
10Morphine addiction_Homo sapiens_hsa050322.50832418
11Dopaminergic synapse_Homo sapiens_hsa047282.27800696
12Collecting duct acid secretion_Homo sapiens_hsa049662.14684394
13Serotonergic synapse_Homo sapiens_hsa047262.07267938
14Taste transduction_Homo sapiens_hsa047422.05506359
15Cocaine addiction_Homo sapiens_hsa050302.00022313
16Oxidative phosphorylation_Homo sapiens_hsa001901.99777693
17Salivary secretion_Homo sapiens_hsa049701.99324357
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.97183651
19Insulin secretion_Homo sapiens_hsa049111.87600104
20Cholinergic synapse_Homo sapiens_hsa047251.85948983
21Long-term depression_Homo sapiens_hsa047301.85152578
22Renin secretion_Homo sapiens_hsa049241.79799440
23Gastric acid secretion_Homo sapiens_hsa049711.74629797
24Parkinsons disease_Homo sapiens_hsa050121.66361109
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65246530
26Cardiac muscle contraction_Homo sapiens_hsa042601.63540943
27Calcium signaling pathway_Homo sapiens_hsa040201.59297113
28Alzheimers disease_Homo sapiens_hsa050101.57778031
29Oxytocin signaling pathway_Homo sapiens_hsa049211.55254391
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.48390978
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46518748
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.45574770
33Gap junction_Homo sapiens_hsa045401.38823373
34GnRH signaling pathway_Homo sapiens_hsa049121.38185828
35Vibrio cholerae infection_Homo sapiens_hsa051101.33780734
36Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.27323357
37Phototransduction_Homo sapiens_hsa047441.19880870
38Axon guidance_Homo sapiens_hsa043601.18118607
39Huntingtons disease_Homo sapiens_hsa050161.11894658
40Estrogen signaling pathway_Homo sapiens_hsa049151.08299781
41cAMP signaling pathway_Homo sapiens_hsa040241.06195263
42Melanogenesis_Homo sapiens_hsa049161.01084173
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96260422
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94547231
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94544682
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.89762341
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89512049
48Type II diabetes mellitus_Homo sapiens_hsa049300.89287564
49ErbB signaling pathway_Homo sapiens_hsa040120.88789379
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.86929102
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86034414
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85389372
53Glioma_Homo sapiens_hsa052140.84394265
54Oocyte meiosis_Homo sapiens_hsa041140.76978996
55Dorso-ventral axis formation_Homo sapiens_hsa043200.75012079
56Pancreatic secretion_Homo sapiens_hsa049720.73080882
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72544667
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70996570
59Protein export_Homo sapiens_hsa030600.69782464
60Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.69361754
61Ether lipid metabolism_Homo sapiens_hsa005650.69229880
62Thyroid hormone synthesis_Homo sapiens_hsa049180.68034240
63Alcoholism_Homo sapiens_hsa050340.65534462
64Type I diabetes mellitus_Homo sapiens_hsa049400.63979581
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.61672278
66Dilated cardiomyopathy_Homo sapiens_hsa054140.61375690
67MAPK signaling pathway_Homo sapiens_hsa040100.61064959
68Linoleic acid metabolism_Homo sapiens_hsa005910.60736405
69Histidine metabolism_Homo sapiens_hsa003400.60367646
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59658953
71African trypanosomiasis_Homo sapiens_hsa051430.57947294
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57107509
73Choline metabolism in cancer_Homo sapiens_hsa052310.56082817
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55984690
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54637724
76Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54098851
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.52430545
78Glucagon signaling pathway_Homo sapiens_hsa049220.48718083
79Prion diseases_Homo sapiens_hsa050200.48638409
80Ras signaling pathway_Homo sapiens_hsa040140.47387664
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46960768
82Tryptophan metabolism_Homo sapiens_hsa003800.46535051
83Rheumatoid arthritis_Homo sapiens_hsa053230.46457285
84Regulation of autophagy_Homo sapiens_hsa041400.45271000
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45036951
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44452762
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43913304
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43745096
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.42640519
90Wnt signaling pathway_Homo sapiens_hsa043100.42148556
91Nitrogen metabolism_Homo sapiens_hsa009100.41990160
92VEGF signaling pathway_Homo sapiens_hsa043700.41519372
93beta-Alanine metabolism_Homo sapiens_hsa004100.40526913
94Rap1 signaling pathway_Homo sapiens_hsa040150.37056326
95Neurotrophin signaling pathway_Homo sapiens_hsa047220.36990355
96Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36895903
97Renal cell carcinoma_Homo sapiens_hsa052110.36274139
98Inositol phosphate metabolism_Homo sapiens_hsa005620.35293518
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31697532
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31632170
101Butanoate metabolism_Homo sapiens_hsa006500.31160659
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30784192
103Mineral absorption_Homo sapiens_hsa049780.30539860
104Fatty acid biosynthesis_Homo sapiens_hsa000610.30165840
105Ovarian steroidogenesis_Homo sapiens_hsa049130.29208788
106Hedgehog signaling pathway_Homo sapiens_hsa043400.28797993
107Circadian rhythm_Homo sapiens_hsa047100.28730136
108Phagosome_Homo sapiens_hsa041450.28690255
109Vitamin B6 metabolism_Homo sapiens_hsa007500.28689413
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25992564
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23340010
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22959018
113Insulin signaling pathway_Homo sapiens_hsa049100.22391745
114Endocytosis_Homo sapiens_hsa041440.20246482
115Hippo signaling pathway_Homo sapiens_hsa043900.19089783
116Bile secretion_Homo sapiens_hsa049760.18059862
117Non-small cell lung cancer_Homo sapiens_hsa052230.17549535
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17199752

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