CEL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a glycoprotein secreted from the pancreas into the digestive tract and from the lactating mammary gland into human milk. The physiological role of this protein is in cholesterol and lipid-soluble vitamin ester hydrolysis and absorption. This encoded protein promotes large chylomicron production in the intestine. Also its presence in plasma suggests its interactions with cholesterol and oxidized lipoproteins to modulate the progression of atherosclerosis. In pancreatic tumoral cells, this encoded protein is thought to be sequestrated within the Golgi compartment and is probably not secreted. This gene contains a variable number of tandem repeat (VNTR) polymorphism in the coding region that may influence the function of the encoded protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vascular endothelial growth factor signaling pathway (GO:1900746)9.97961877
2transcytosis (GO:0045056)8.80184618
3regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)8.70783402
4positive regulation of p38MAPK cascade (GO:1900745)7.98630495
5cobalamin metabolic process (GO:0009235)7.79994687
6COPI coating of Golgi vesicle (GO:0048205)7.75205227
7Golgi transport vesicle coating (GO:0048200)7.75205227
8peptidyl-proline hydroxylation (GO:0019511)6.96288196
9phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.51655806
10negative regulation of digestive system process (GO:0060457)6.34204081
11oligosaccharide biosynthetic process (GO:0009312)6.16059777
12regulation of p38MAPK cascade (GO:1900744)6.13644549
13glycolipid catabolic process (GO:0019377)6.01125195
14activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.90066750
15regulation of phospholipase A2 activity (GO:0032429)5.83038080
16phosphatidylinositol acyl-chain remodeling (GO:0036149)5.72875099
17innate immune response in mucosa (GO:0002227)5.66744277
18phosphatidylserine acyl-chain remodeling (GO:0036150)5.65230342
19positive regulation of nuclease activity (GO:0032075)5.63835205
20cysteine metabolic process (GO:0006534)5.53718833
21protein hydroxylation (GO:0018126)5.43478362
22protein maturation by protein folding (GO:0022417)5.30534157
23proline biosynthetic process (GO:0006561)5.30104641
24valine metabolic process (GO:0006573)5.30073838
25icosanoid transport (GO:0071715)5.22025391
26fatty acid derivative transport (GO:1901571)5.22025391
27endoplasmic reticulum unfolded protein response (GO:0030968)5.19565450
28* intestinal absorption (GO:0050892)5.14765599
29regulation of nuclease activity (GO:0032069)5.12191414
30lactation (GO:0007595)5.08891925
31nucleobase catabolic process (GO:0046113)5.08072169
32cellular response to unfolded protein (GO:0034620)5.03349425
33response to endoplasmic reticulum stress (GO:0034976)5.00337370
34branched-chain amino acid catabolic process (GO:0009083)4.96667478
35endocrine pancreas development (GO:0031018)4.91462756
36zinc ion transport (GO:0006829)4.89032645
37ER-nucleus signaling pathway (GO:0006984)4.83502021
38COPII vesicle coating (GO:0048208)4.83405379
39intestinal epithelial cell development (GO:0060576)4.80153304
40regulation of endothelial cell differentiation (GO:0045601)4.79586051
41regulation of keratinocyte differentiation (GO:0045616)4.77523962
42cellular response to topologically incorrect protein (GO:0035967)4.76668407
43retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.56338926
44branched-chain amino acid metabolic process (GO:0009081)4.55866601
45mucosal immune response (GO:0002385)4.55628460
46phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.55119707
47negative regulation of epithelial cell differentiation (GO:0030857)4.54204670
48regulation of keratinocyte proliferation (GO:0010837)4.47728509
49myeloid leukocyte mediated immunity (GO:0002444)4.47515160
50cellular modified amino acid catabolic process (GO:0042219)4.39208270
514-hydroxyproline metabolic process (GO:0019471)4.38385505
52phosphatidic acid biosynthetic process (GO:0006654)4.36061152
53phosphatidic acid metabolic process (GO:0046473)4.36061152
54mitochondrial calcium ion transport (GO:0006851)4.23323511
55signal peptide processing (GO:0006465)4.22084775
56regulation of acrosome reaction (GO:0060046)4.21722786
57maintenance of protein localization in organelle (GO:0072595)4.21518732
58negative regulation of execution phase of apoptosis (GO:1900118)4.17959170
59ER overload response (GO:0006983)4.15768871
60organ or tissue specific immune response (GO:0002251)4.12151465
61ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.07569091
62regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.07240371
63response to unfolded protein (GO:0006986)4.05981306
64homocysteine metabolic process (GO:0050667)4.03822557
65phosphatidylserine metabolic process (GO:0006658)4.01729283
66negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.91672795
67regulation of vasculogenesis (GO:2001212)3.90359509
68alditol phosphate metabolic process (GO:0052646)3.89560115
69protein N-linked glycosylation via asparagine (GO:0018279)3.89458412
70response to topologically incorrect protein (GO:0035966)3.89368767
71peptidyl-asparagine modification (GO:0018196)3.87742367
72phosphatidylcholine acyl-chain remodeling (GO:0036151)3.84703828
73response to phenylpropanoid (GO:0080184)3.81711892
74regulation of cholesterol homeostasis (GO:2000188)3.79785386
75regulation of sequestering of triglyceride (GO:0010889)3.76076076
76L-alpha-amino acid transmembrane transport (GO:1902475)3.74417837
77glutamine metabolic process (GO:0006541)3.71854881
78positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.65062390
79long-chain fatty acid transport (GO:0015909)3.62335206
80positive regulation of heat generation (GO:0031652)3.61015936
81* secretion by tissue (GO:0032941)3.60959457
82leukotriene biosynthetic process (GO:0019370)3.60652970
83negative regulation of epidermal cell differentiation (GO:0045605)3.59595448
84aspartate family amino acid catabolic process (GO:0009068)3.59257954
85protein N-linked glycosylation (GO:0006487)3.57111673
86* digestive system process (GO:0022600)3.56533239
87serine family amino acid biosynthetic process (GO:0009070)3.53452386
88vesicle coating (GO:0006901)3.52841136
89water-soluble vitamin metabolic process (GO:0006767)3.46428551
90endothelial cell migration (GO:0043542)3.45088022
91negative regulation of protein kinase B signaling (GO:0051898)3.42475115
92creatine metabolic process (GO:0006600)3.39784079
93proline metabolic process (GO:0006560)3.39089711
94regulation of fever generation (GO:0031620)3.37996717
95Golgi organization (GO:0007030)3.36004086
96leukotriene metabolic process (GO:0006691)3.34562395
97regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.32975161
98antibacterial humoral response (GO:0019731)3.31667390
99ectoderm development (GO:0007398)3.31191494
100GDP-mannose metabolic process (GO:0019673)3.30338298
101phospholipid catabolic process (GO:0009395)3.29316761
102acute-phase response (GO:0006953)3.24804844
103coenzyme catabolic process (GO:0009109)3.24361659
104biotin metabolic process (GO:0006768)3.23030050
105insulin-like growth factor receptor signaling pathway (GO:0048009)3.22696550
106cell redox homeostasis (GO:0045454)3.22439336
107mammary gland epithelial cell differentiation (GO:0060644)3.21236395
108* membrane lipid catabolic process (GO:0046466)3.20666169
109neutrophil mediated immunity (GO:0002446)3.18212186
110polarized epithelial cell differentiation (GO:0030859)3.16882910
111maintenance of gastrointestinal epithelium (GO:0030277)3.16503564
112pancreas development (GO:0031016)3.15212034
113phosphatidylglycerol metabolic process (GO:0046471)3.14952033
114mitochondrion distribution (GO:0048311)3.08837382
115* body fluid secretion (GO:0007589)3.08722087
116antimicrobial humoral response (GO:0019730)3.07181018
117* cholesterol transport (GO:0030301)3.06268983
118* sterol transport (GO:0015918)3.06268983
119atrioventricular valve morphogenesis (GO:0003181)3.05558464
120cellular protein catabolic process (GO:0044257)3.02723015
121L-phenylalanine catabolic process (GO:0006559)3.02380706
122erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.02380706
123retinoid metabolic process (GO:0001523)2.99885162
124defense response to Gram-positive bacterium (GO:0050830)2.97442776
125UDP-N-acetylglucosamine metabolic process (GO:0006047)2.94058965
126regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.93185958
127membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.86059908
128icosanoid secretion (GO:0032309)2.84074697
129arachidonic acid secretion (GO:0050482)2.84074697
130diterpenoid metabolic process (GO:0016101)2.83737964
131regulation of apoptotic cell clearance (GO:2000425)2.83269912
132positive regulation of lipid storage (GO:0010884)2.82564431
133erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81156885
134L-phenylalanine metabolic process (GO:0006558)2.81156885
135regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.80635477
136fatty acid transport (GO:0015908)2.76188474
137L-serine metabolic process (GO:0006563)2.74650008
138macroautophagy (GO:0016236)2.72939969
139columnar/cuboidal epithelial cell development (GO:0002066)2.72702053
140regulation of heat generation (GO:0031650)2.70518137
141serine family amino acid metabolic process (GO:0009069)2.70470663
142regulation of oxidative stress-induced cell death (GO:1903201)2.70069695
143negative regulation of epidermis development (GO:0045683)2.69444450
144phospholipid homeostasis (GO:0055091)2.68599022
145regulation of epidermal cell differentiation (GO:0045604)2.68344363
146ER to Golgi vesicle-mediated transport (GO:0006888)2.67622809
147glandular epithelial cell differentiation (GO:0002067)2.66011330
148peptide catabolic process (GO:0043171)2.65939243
149calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.65605322
150regulation of digestive system process (GO:0044058)2.65376110
151epithelial cell migration (GO:0010631)2.62416471
152negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.60039975
153vitamin metabolic process (GO:0006766)2.58280284
154regulation of phospholipid biosynthetic process (GO:0071071)2.55868863
155nucleotide-sugar biosynthetic process (GO:0009226)2.55400758
156establishment of apical/basal cell polarity (GO:0035089)2.54197015
157membrane repolarization during action potential (GO:0086011)2.53831698
158endoplasmic reticulum organization (GO:0007029)2.53356373
159tetrapyrrole metabolic process (GO:0033013)2.52089683
160icosanoid biosynthetic process (GO:0046456)2.48937453
161fatty acid derivative biosynthetic process (GO:1901570)2.48937453
162peptidyl-proline modification (GO:0018208)2.48611652
163temperature homeostasis (GO:0001659)2.47278093
164terpenoid metabolic process (GO:0006721)2.46314139
165exocrine pancreas development (GO:0031017)16.4512471
166* digestion (GO:0007586)12.6930079
167protein retention in ER lumen (GO:0006621)12.2996645
168maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.7416363
169* intestinal cholesterol absorption (GO:0030299)10.8843445

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.50732138
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.21527287
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.97962912
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.84129612
5GATA1_22025678_ChIP-Seq_K562_Human3.05549318
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.83463122
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.83214900
8STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.74570016
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.67835125
10ESR1_21235772_ChIP-Seq_MCF-7_Human2.67387515
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.64539357
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.58303774
13GATA4_25053715_ChIP-Seq_YYC3_Human2.57975326
14LXR_22158963_ChIP-Seq_LIVER_Mouse2.53697871
15ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.49454366
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.40366205
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.23271087
18GATA6_25053715_ChIP-Seq_YYC3_Human2.17825303
19CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.87155884
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75443101
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.74920887
22CLOCK_20551151_ChIP-Seq_293T_Human1.72568416
23FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.61179032
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60565114
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.59711340
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59060918
27PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.54803749
28TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.54357810
29CHD1_26751641_Chip-Seq_LNCaP_Human1.52542634
30CREB1_26743006_Chip-Seq_LNCaP_Human1.51622052
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45332576
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44067802
33CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42800708
34FOXO3_23340844_ChIP-Seq_DLD1_Human1.40288205
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.39892116
36FOXA2_19822575_ChIP-Seq_HepG2_Human1.35156740
37SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.34557268
38AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.32398482
39SOX2_20726797_ChIP-Seq_SW620_Human1.31034164
40ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30985144
41FOXA1_25552417_ChIP-Seq_VCAP_Human1.29582288
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.26650457
43LXR_22292898_ChIP-Seq_THP-1_Human1.26480973
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.26194289
45HTT_18923047_ChIP-ChIP_STHdh_Human1.25558200
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24049610
47ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23932118
48FLI1_21867929_ChIP-Seq_CD8_Mouse1.19368321
49DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19130249
50NFYA_21822215_ChIP-Seq_K562_Human1.19084092
51PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.19052013
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.18546636
53ATF3_27146783_Chip-Seq_COLON_Human1.17933094
54ETV1_20927104_ChIP-Seq_GIST48_Human1.16393952
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16106082
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15013369
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15013369
58KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15013369
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14369997
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11732525
61ERG_20517297_ChIP-Seq_VCAP_Human1.11208163
62TCF4_18268006_ChIP-ChIP_LS174T_Human1.10535289
63CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09661433
64GATA3_24758297_ChIP-Seq_MCF-7_Human1.09382616
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08782139
66CDX2_20551321_ChIP-Seq_CACO-2_Human1.08663916
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.08390946
68FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.08148965
69FOXH1_21741376_ChIP-Seq_ESCs_Human1.08118854
70KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07685293
71KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07470493
72RACK7_27058665_Chip-Seq_MCF-7_Human1.07210756
73P68_20966046_ChIP-Seq_HELA_Human1.06985678
74TBX20_22328084_ChIP-Seq_HEART_Mouse1.05583484
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.05583484
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05262148
77* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04636034
78PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04545247
79CBX2_22325352_ChIP-Seq_293T-Rex_Human1.04173753
80RBPJ_21746931_ChIP-Seq_IB4_Human1.03883386
81FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03503774
82EGR1_19032775_ChIP-ChIP_M12_Human1.03308143
83GATA6_21074721_ChIP-Seq_CACO-2_Human1.03051295
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02342237
85NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02130942
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.02127888
87* TP63_22573176_ChIP-Seq_HFKS_Human1.01625639
88HNFA_21074721_ChIP-Seq_CACO-2_Human1.01328339
89PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99471592
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99443116
91PHF8_20622853_ChIP-Seq_HELA_Human0.97656911
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96393758
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95270142
94NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94700962
95GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94167443
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94110602
97KDM2B_26808549_Chip-Seq_K562_Human0.92716168
98GATA1_19941826_ChIP-Seq_K562_Human0.90621419
99TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89262952
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.87744023
101KLF5_25053715_ChIP-Seq_YYC3_Human0.86913712
102ZNF274_21170338_ChIP-Seq_K562_Hela0.86251839
103SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.85872039
104* ESET_19884257_ChIP-Seq_ESCs_Mouse0.85512825
105KLF4_19829295_ChIP-Seq_ESCs_Human0.85416375
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84256943
107JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82867228
108LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82262925
109DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82238398
110ERA_21632823_ChIP-Seq_H3396_Human0.82009036
111OCT4_20526341_ChIP-Seq_ESCs_Human0.81892455
112ETS1_21867929_ChIP-Seq_TH2_Mouse0.81806541
113SA1_27219007_Chip-Seq_Bcells_Human0.81372176
114CTCF_27219007_Chip-Seq_Bcells_Human0.80816028
115NFYB_21822215_ChIP-Seq_K562_Human0.79969124
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79739281
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.79698212
118SOX9_24532713_ChIP-Seq_HFSC_Mouse0.79330013
119TAF2_19829295_ChIP-Seq_ESCs_Human0.78984798
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78737311
121FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.78205135
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.77885815
123P53_21459846_ChIP-Seq_SAOS-2_Human0.77684422
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.77430643
125JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76229185
126CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.74266780
127* LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.73946891
128PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.73754886
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73706583
130BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.71762813
131P300_27058665_Chip-Seq_ZR-75-30cells_Human0.70970905
132CEBPB_22108803_ChIP-Seq_LS180_Human0.70740327
133CBP_21632823_ChIP-Seq_H3396_Human0.70582604
134* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69660494
135STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.69042688
136RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.68736043
137SOX2_21211035_ChIP-Seq_LN229_Human0.68615077
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.66022983
139SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.65863142
140SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.65863142

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.37158145
2* MP0001666_abnormal_nutrient_absorption7.64285141
3MP0005220_abnormal_exocrine_pancreas6.40147987
4MP0005365_abnormal_bile_salt6.23484555
5MP0003868_abnormal_feces_composition5.21849702
6MP0005084_abnormal_gallbladder_morpholo4.78933748
7MP0005085_abnormal_gallbladder_physiolo3.38897418
8MP0002693_abnormal_pancreas_physiology3.21047759
9MP0002138_abnormal_hepatobiliary_system2.71308991
10MP0001944_abnormal_pancreas_morphology2.41885132
11MP0001664_abnormal_digestion2.38485301
12MP0004264_abnormal_extraembryonic_tissu2.30802539
13MP0000627_abnormal_mammary_gland2.24331665
14MP0002139_abnormal_hepatobiliary_system2.20181325
15MP0003705_abnormal_hypodermis_morpholog2.18815311
16MP0010234_abnormal_vibrissa_follicle2.13245120
17MP0003252_abnormal_bile_duct1.84593735
18MP0002928_abnormal_bile_duct1.67548125
19MP0003283_abnormal_digestive_organ1.62562643
20* MP0003959_abnormal_lean_body1.62233145
21MP0003300_gastrointestinal_ulcer1.49677637
22MP0003718_maternal_effect1.42559325
23MP0004233_abnormal_muscle_weight1.35827702
24MP0008004_abnormal_stomach_pH1.25099323
25MP0003638_abnormal_response/metabolism_1.22582707
26* MP0002118_abnormal_lipid_homeostasis1.22444988
27MP0006054_spinal_hemorrhage1.20761833
28* MP0002078_abnormal_glucose_homeostasis1.19131031
29MP0009780_abnormal_chondrocyte_physiolo1.18243766
30MP0000003_abnormal_adipose_tissue1.17515121
31MP0005165_increased_susceptibility_to1.17118059
32* MP0005448_abnormal_energy_balance1.14033348
33MP0003045_fibrosis1.12937227
34MP0004019_abnormal_vitamin_homeostasis1.06449352
35MP0002132_abnormal_respiratory_system1.05170750
36MP0005332_abnormal_amino_acid1.04759258
37MP0000470_abnormal_stomach_morphology1.02012966
38MP0008961_abnormal_basal_metabolism1.01046123
39MP0010352_gastrointestinal_tract_polyps1.00729100
40MP0002277_abnormal_respiratory_mucosa0.98555767
41MP0002877_abnormal_melanocyte_morpholog0.93120457
42MP0001849_ear_inflammation0.92852505
43MP0009643_abnormal_urine_homeostasis0.91374605
44MP0001881_abnormal_mammary_gland0.90378842
45MP0008438_abnormal_cutaneous_collagen0.89326719
46MP0005408_hypopigmentation0.87650188
47MP0001873_stomach_inflammation0.86046486
48MP0000613_abnormal_salivary_gland0.83992754
49MP0005535_abnormal_body_temperature0.82958889
50MP0002163_abnormal_gland_morphology0.82921908
51MP0009384_cardiac_valve_regurgitation0.82839129
52MP0003566_abnormal_cell_adhesion0.81345672
53MP0002970_abnormal_white_adipose0.80359644
54MP0005395_other_phenotype0.78724707
55* MP0003953_abnormal_hormone_level0.78374730
56MP0002896_abnormal_bone_mineralization0.74317135
57MP0000490_abnormal_crypts_of0.70650399
58MP0001502_abnormal_circadian_rhythm0.70455135
59MP0005058_abnormal_lysosome_morphology0.69204093
60MP0004043_abnormal_pH_regulation0.66902400
61MP0005375_adipose_tissue_phenotype0.66625498
62MP0003866_abnormal_defecation0.65396484
63MP0010329_abnormal_lipoprotein_level0.65201250
64MP0000013_abnormal_adipose_tissue0.64559825
65MP0004185_abnormal_adipocyte_glucose0.63924498
66MP0003195_calcinosis0.62719628
67MP0005451_abnormal_body_composition0.61420238
68MP0003879_abnormal_hair_cell0.61356408
69MP0005636_abnormal_mineral_homeostasis0.58714005
70MP0002254_reproductive_system_inflammat0.58564921
71MP0003183_abnormal_peptide_metabolism0.58137379
72MP0005410_abnormal_fertilization0.57772751
73MP0003936_abnormal_reproductive_system0.56077004
74MP0000609_abnormal_liver_physiology0.55269433
75MP0008789_abnormal_olfactory_epithelium0.54126158
76MP0010386_abnormal_urinary_bladder0.53384364
77MP0002098_abnormal_vibrissa_morphology0.53219005
78MP0003011_delayed_dark_adaptation0.52169609
79MP0000858_altered_metastatic_potential0.52127692
80MP0001663_abnormal_digestive_system0.52032256
81MP0003091_abnormal_cell_migration0.51827882
82MP0001731_abnormal_postnatal_growth0.50429885
83MP0004272_abnormal_basement_membrane0.50081432
84MP0002909_abnormal_adrenal_gland0.49553131
85MP0005381_digestive/alimentary_phenotyp0.49184141
86MP0008770_decreased_survivor_rate0.49120965
87MP0009703_decreased_birth_body0.47153407
88* MP0005452_abnormal_adipose_tissue0.46817885
89MP0005645_abnormal_hypothalamus_physiol0.46591180
90MP0002796_impaired_skin_barrier0.46248710
91MP0005409_darkened_coat_color0.45774897
92MP0005187_abnormal_penis_morphology0.45446967
93MP0005334_abnormal_fat_pad0.45432739
94MP0003122_maternal_imprinting0.45114064
95MP0003943_abnormal_hepatobiliary_system0.44846798
96MP0003329_amyloid_beta_deposits0.44659714
97* MP0000598_abnormal_liver_morphology0.43379366
98MP0005377_hearing/vestibular/ear_phenot0.42878568
99MP0003878_abnormal_ear_physiology0.42878568
100MP0003453_abnormal_keratinocyte_physiol0.42671997
101MP0003795_abnormal_bone_structure0.42250746
102MP0002060_abnormal_skin_morphology0.41719622
103MP0002234_abnormal_pharynx_morphology0.40731091
104MP0000377_abnormal_hair_follicle0.39655781
105MP0005394_taste/olfaction_phenotype0.38517854
106MP0005499_abnormal_olfactory_system0.38517854
107MP0001765_abnormal_ion_homeostasis0.37611532
108MP0009672_abnormal_birth_weight0.37324904
109MP0003950_abnormal_plasma_membrane0.37171444
110MP0004130_abnormal_muscle_cell0.36860559
111MP0003806_abnormal_nucleotide_metabolis0.36788940
112MP0001727_abnormal_embryo_implantation0.36593338
113MP0010678_abnormal_skin_adnexa0.36514091
114MP0001845_abnormal_inflammatory_respons0.36226901
115MP0000678_abnormal_parathyroid_gland0.36191968
116MP0005379_endocrine/exocrine_gland_phen0.35814130
117MP0009642_abnormal_blood_homeostasis0.34671241
118MP0009840_abnormal_foam_cell0.34549834
119MP0002089_abnormal_postnatal_growth/wei0.34246617
120MP0002168_other_aberrant_phenotype0.33939355
121MP0002069_abnormal_eating/drinking_beha0.33831875
122MP0009765_abnormal_xenobiotic_induced0.33735466
123MP0001501_abnormal_sleep_pattern0.33611716
124MP0006036_abnormal_mitochondrial_physio0.33459722
125MP0002876_abnormal_thyroid_physiology0.33200672
126MP0000371_diluted_coat_color0.33092451
127MP0000367_abnormal_coat/_hair0.32686841
128MP0005319_abnormal_enzyme/_coenzyme0.32671150
129MP0000462_abnormal_digestive_system0.31832084
130MP0003119_abnormal_digestive_system0.31775625
131MP0001756_abnormal_urination0.31644944
132MP0003172_abnormal_lysosome_physiology0.31231400

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.59831206
2Gout (HP:0001997)6.57349367
3Fat malabsorption (HP:0002630)6.53400758
4Exocrine pancreatic insufficiency (HP:0001738)5.20285291
5Abnormal pancreas size (HP:0012094)5.00959063
6Decreased subcutaneous fat (HP:0001002)4.70489264
7Abnormality of the pancreatic islet cells (HP:0006476)4.54012172
8Abnormality of endocrine pancreas physiology (HP:0012093)4.54012172
9Abnormality of the intrinsic pathway (HP:0010989)4.41157461
10Short chin (HP:0000331)4.39475341
11Ketoacidosis (HP:0001993)4.32352368
12Abnormality of subcutaneous fat tissue (HP:0001001)4.27754733
13Nephritis (HP:0000123)4.17231654
14Type I diabetes mellitus (HP:0100651)4.17146076
15Hyperinsulinemic hypoglycemia (HP:0000825)4.04857237
16Hypoglycemic seizures (HP:0002173)3.92872855
17Hypoglycemic coma (HP:0001325)3.89916719
18Hypoplasia of the pons (HP:0012110)3.87793612
19Ketosis (HP:0001946)3.71134032
20Tubulointerstitial fibrosis (HP:0005576)3.70144099
21Thin bony cortex (HP:0002753)3.61226876
22Abnormality of the pons (HP:0007361)3.57448387
23Maternal diabetes (HP:0009800)3.55229122
24Pancreatitis (HP:0001733)3.45291869
25Tubulointerstitial nephritis (HP:0001970)3.38618390
26Late onset (HP:0003584)3.38067348
27Abnormality of the pleura (HP:0002103)3.37130362
28Hyperactive renin-angiotensin system (HP:0000841)3.24261600
29Premature skin wrinkling (HP:0100678)3.23209927
30Abnormality of aromatic amino acid family metabolism (HP:0004338)3.17322258
31Hypoproteinemia (HP:0003075)3.16783156
32Symptomatic seizures (HP:0011145)3.13042188
33Hyperglycemia (HP:0003074)3.06327274
34Cortical dysplasia (HP:0002539)3.04497480
35Male infertility (HP:0003251)3.01820940
36Abnormality of nucleobase metabolism (HP:0010932)3.01017629
37Decreased circulating renin level (HP:0003351)2.90659943
38Increased purine levels (HP:0004368)2.90484580
39Hyperuricemia (HP:0002149)2.90484580
40Joint stiffness (HP:0001387)2.88537277
41Ileus (HP:0002595)2.87366655
42Abnormality of chloride homeostasis (HP:0011422)2.87033562
43Abnormality of the common coagulation pathway (HP:0010990)2.85493725
44Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.73770387
45Pancreatic islet-cell hyperplasia (HP:0004510)2.65688981
46Large for gestational age (HP:0001520)2.65639776
47Abnormality of purine metabolism (HP:0004352)2.64412389
48Carpal bone hypoplasia (HP:0001498)2.61749240
49Insulin-resistant diabetes mellitus (HP:0000831)2.60904506
50Congenital glaucoma (HP:0001087)2.58549060
51Esophageal varix (HP:0002040)2.44422091
52Ventricular fibrillation (HP:0001663)2.40904884
53Hyperglycinemia (HP:0002154)2.36083168
54Long foot (HP:0001833)2.34848493
55Abnormal tarsal ossification (HP:0008369)2.32851898
56Dysostosis multiplex (HP:0000943)2.30042660
57Fatigue (HP:0012378)2.29896964
58Facial shape deformation (HP:0011334)2.29541018
59Potter facies (HP:0002009)2.29541018
60Tetraparesis (HP:0002273)2.27943129
61Abnormality of the renal cortex (HP:0011035)2.26983882
62Conjugated hyperbilirubinemia (HP:0002908)2.26774363
63Abnormality of sulfur amino acid metabolism (HP:0004339)2.26247107
64Deformed sella turcica (HP:0002681)2.25184167
65Malnutrition (HP:0004395)2.21014740
66Hypoplasia of the odontoid process (HP:0003311)2.19708535
67Right ventricular cardiomyopathy (HP:0011663)2.18535011
68Unilateral renal agenesis (HP:0000122)2.16805779
69Villous atrophy (HP:0011473)2.16184036
70Abnormality of small intestinal villus morphology (HP:0011472)2.16184036
71Vascular calcification (HP:0004934)2.15129657
72Ankyloglossia (HP:0010296)2.14939742
73Cortical visual impairment (HP:0100704)2.14542205
74Severe short stature (HP:0003510)2.14392058
75Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.13402700
76Abnormal protein N-linked glycosylation (HP:0012347)2.13402700
77Abnormal protein glycosylation (HP:0012346)2.13402700
78Abnormal glycosylation (HP:0012345)2.13402700
79Pectus carinatum (HP:0000768)2.12301719
80Flat acetabular roof (HP:0003180)2.10599710
81Tubular atrophy (HP:0000092)2.10577806
82Progressive muscle weakness (HP:0003323)2.10278069
83Insulin resistance (HP:0000855)2.10239182
84Tubulointerstitial abnormality (HP:0001969)2.08514477
85Hyperglycinuria (HP:0003108)2.05910095
86Acute hepatic failure (HP:0006554)2.04953486
87Enlarged penis (HP:0000040)2.02845968
88Anal atresia (HP:0002023)2.02206805
89Hypotension (HP:0002615)2.02084589
90Neoplasm of the heart (HP:0100544)2.01966724
91Hydroxyprolinuria (HP:0003080)2.01256630
92Abnormality of proline metabolism (HP:0010907)2.01256630
93Hyperphosphatemia (HP:0002905)2.00689028
94Small epiphyses (HP:0010585)2.00229585
95Prenatal maternal abnormality (HP:0002686)1.95587505
96Hypsarrhythmia (HP:0002521)1.95507132
97Mucopolysacchariduria (HP:0008155)1.95168173
98Urinary glycosaminoglycan excretion (HP:0003541)1.95168173
99Abnormality of renin-angiotensin system (HP:0000847)1.93602634
100Limb hypertonia (HP:0002509)1.93032964
101Type II lissencephaly (HP:0007260)1.92236915
102Broad metatarsal (HP:0001783)1.90886399
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.90703174
104Prolonged QT interval (HP:0001657)1.89953462
105Abdominal distention (HP:0003270)1.88452564
106Neonatal death (HP:0003811)1.87688744
107Epiphyseal dysplasia (HP:0002656)1.87666882
108Vacuolated lymphocytes (HP:0001922)1.86958695
109EEG with generalized epileptiform discharges (HP:0011198)1.86097114
110Epidermoid cyst (HP:0200040)1.86038926
111Renal salt wasting (HP:0000127)1.84270309
112Abnormality of serine family amino acid metabolism (HP:0010894)1.83714373
113Abnormality of glycine metabolism (HP:0010895)1.83714373
114Cardiovascular calcification (HP:0011915)1.82612999
115Hyperkalemia (HP:0002153)1.82083856
116Azoospermia (HP:0000027)1.81806921
117Abnormality of calcium-phosphate metabolism (HP:0100530)1.81563765
118Abnormal foot bone ossification (HP:0010675)1.81317667
119Axonal loss (HP:0003447)1.81216582
120Glomerulosclerosis (HP:0000096)1.80568627
121Hyperlipoproteinemia (HP:0010980)1.80383397
122Barrel-shaped chest (HP:0001552)1.80036826
123Myocardial infarction (HP:0001658)1.79427071
124Hyperaldosteronism (HP:0000859)1.78859684
125Intrahepatic cholestasis (HP:0001406)1.78001669
126Rectal prolapse (HP:0002035)1.77549480
127Skin nodule (HP:0200036)1.77453384
128Glucose intolerance (HP:0000833)1.76075935
129Epileptiform EEG discharges (HP:0011182)1.75441158
130Optic nerve hypoplasia (HP:0000609)1.72498634
131Abnormality of the odontoid process (HP:0003310)1.72220940
132Absent eyelashes (HP:0000561)1.71730134
133Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71294525
134Hypoplasia of dental enamel (HP:0006297)1.71218998
135J-shaped sella turcica (HP:0002680)1.68651262
136Xanthomatosis (HP:0000991)1.66897726
137Popliteal pterygium (HP:0009756)1.66186744
138Germ cell neoplasia (HP:0100728)1.57149435
139Dehydration (HP:0001944)1.54155970
140Thoracic kyphosis (HP:0002942)1.52993697
141Abnormality of the right ventricle (HP:0001707)1.52854049
142Nephrolithiasis (HP:0000787)1.52553087
143Abnormal biliary tract morphology (HP:0012440)1.50027834
144Abnormality of glutamine family amino acid metabolism (HP:0010902)1.49427749
145Abdominal pain (HP:0002027)1.49160941
146Hypercalciuria (HP:0002150)1.49055071
147Abnormality of the sella turcica (HP:0002679)1.47934952
148Elevated alkaline phosphatase (HP:0003155)1.46179682
149Abnormality of the distal phalanges of the toes (HP:0010182)1.46040160
150Abnormality of the costochondral junction (HP:0000919)1.45487503
151Spinal canal stenosis (HP:0003416)1.42680396
152Abnormality of alkaline phosphatase activity (HP:0004379)1.41885684
153Abnormal enzyme/coenzyme activity (HP:0012379)1.39654336
154Bronchomalacia (HP:0002780)1.39534007
155Protuberant abdomen (HP:0001538)1.37039026
156Lymphangioma (HP:0100764)1.33673139
157Abnormality of the nasal septum (HP:0000419)1.33540279
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.33226394
159Abnormality of polysaccharide metabolism (HP:0011012)1.33226394
160Abnormality of glycosaminoglycan metabolism (HP:0004371)1.33226394

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK28.65177032
2BCKDK7.67148972
3ERN14.75042788
4EPHA24.08405936
5EIF2AK33.92097813
6TRIB33.90958471
7INSRR3.84230779
8PKN23.52057196
9MAP2K23.46579248
10FRK2.91551745
11TAOK32.71983376
12IRAK31.88348635
13MAPK151.85265849
14ZAP701.84222277
15SIK11.79113997
16MAPKAPK31.78980239
17PTK61.78652753
18SCYL21.70794241
19PRKG21.66787656
20LATS11.56393214
21WNK41.51985649
22MAP3K21.49637121
23ICK1.46388084
24FLT31.41212601
25PDGFRB1.40135390
26EEF2K1.38797116
27NLK1.37882451
28MAP2K11.36996698
29PAK21.32080864
30PASK1.21531839
31TRPM71.16158339
32STK381.04488689
33RPS6KB21.03089423
34RIPK11.02989858
35PRKD31.02969299
36MARK20.99163553
37NME20.97412728
38PDGFRA0.97400452
39SGK30.97035676
40RET0.96876006
41DYRK1A0.96230294
42CAMK1D0.93618442
43CAMKK10.93297881
44MAP3K90.92261984
45PIK3CA0.91846015
46HIPK20.88834825
47MAP3K10.85307685
48MTOR0.83003945
49DYRK1B0.82014437
50NME10.81739988
51PIK3CG0.76807130
52PRKCH0.75373154
53MAP3K60.73629048
54CDK120.72208587
55TESK10.71999861
56PTK20.69992972
57EPHA30.69701635
58IRAK20.69331428
59DAPK20.68889261
60FER0.68667433
61SGK20.68296454
62CAMKK20.68216715
63BMX0.68062249
64FGFR40.65598284
65CHUK0.63962995
66CAMK1G0.63711167
67EPHB10.62565701
68LRRK20.61903827
69PDK20.61289386
70NTRK10.60860075
71MET0.60687957
72SGK2230.60027902
73SGK4940.60027902
74MELK0.58062602
75RPS6KA20.56966987
76STK240.56639123
77PRKCI0.53210903
78GRK10.51964504
79JAK20.51102458
80ROCK10.50869959
81RPS6KB10.49118596
82PDPK10.49077756
83STK390.46956439
84STK38L0.46527031
85STK160.45736691
86IRAK10.45566089
87MAP3K70.44608545
88PRKCZ0.43896604
89ERBB20.43496647
90PRKD10.43207505
91KSR20.41137059
92MAP2K60.37835088
93PDK10.35933825
94IRAK40.35635446
95FGFR30.34383572
96PAK40.34119931
97PRKD20.32518340
98GSK3A0.32213709
99IGF1R0.32050921
100TAOK10.32030472
101PRPF4B0.31825702
102MAP3K30.29892391
103PRKAA10.29430450
104MUSK0.28996579
105MAP3K50.28969874
106DDR20.28294465
107MAP3K130.27846477
108NEK60.26333674
109MAPK30.26241698
110TGFBR20.26065452
111PDK40.25722576
112PDK30.25722576
113CDC42BPA0.25367586
114WNK10.24039812
115ILK0.23401222
116MAPK120.23338826
117KSR10.23190040
118JAK10.21843013
119PRKAA20.21646976
120RPS6KA10.19911840
121IKBKE0.19608818
122JAK30.19036220
123CDK90.18839144
124MAPK10.18778414
125PRKCE0.18572408
126ABL10.18369882
127PRKACB0.17731086
128CSNK1A10.17404048
129NTRK30.16987062
130MAP3K140.16734842
131UHMK10.16687929
132MAP3K120.16480690
133MAP3K100.15771464
134AKT10.14743619
135EGFR0.14635417
136SRC0.14225706
137MST1R0.13853076
138TBK10.12648747
139CSNK1E0.12425986
140NUAK10.11194734

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049728.12653062
2Protein digestion and absorption_Homo sapiens_hsa049745.79250301
3Maturity onset diabetes of the young_Homo sapiens_hsa049505.01790493
4* Fat digestion and absorption_Homo sapiens_hsa049754.95769982
5Protein export_Homo sapiens_hsa030603.68870915
6Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.76900844
7Folate biosynthesis_Homo sapiens_hsa007902.51474037
8* Glycerolipid metabolism_Homo sapiens_hsa005612.05802619
9Cyanoamino acid metabolism_Homo sapiens_hsa004601.99782120
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.94614358
11Vitamin digestion and absorption_Homo sapiens_hsa049771.90715241
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88516992
13Propanoate metabolism_Homo sapiens_hsa006401.60607373
14Renin-angiotensin system_Homo sapiens_hsa046141.45636330
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.36728481
16N-Glycan biosynthesis_Homo sapiens_hsa005101.30722141
17Insulin secretion_Homo sapiens_hsa049111.26740362
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.14429927
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.09315166
20Starch and sucrose metabolism_Homo sapiens_hsa005001.02986943
21Linoleic acid metabolism_Homo sapiens_hsa005910.99101908
22Selenocompound metabolism_Homo sapiens_hsa004500.93790746
23Sulfur metabolism_Homo sapiens_hsa009200.92569469
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89693099
25Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89388255
26Arginine and proline metabolism_Homo sapiens_hsa003300.83809629
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83388580
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77804238
29Vibrio cholerae infection_Homo sapiens_hsa051100.76585451
30Notch signaling pathway_Homo sapiens_hsa043300.73693827
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72763828
32Histidine metabolism_Homo sapiens_hsa003400.72066159
33Other glycan degradation_Homo sapiens_hsa005110.71831151
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71306432
35Influenza A_Homo sapiens_hsa051640.70348739
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66908390
37Biosynthesis of amino acids_Homo sapiens_hsa012300.65812631
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65530391
39Circadian rhythm_Homo sapiens_hsa047100.65090446
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65054509
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58741740
42Type II diabetes mellitus_Homo sapiens_hsa049300.53169316
43Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51337683
44Glycerophospholipid metabolism_Homo sapiens_hsa005640.51050415
45Pyruvate metabolism_Homo sapiens_hsa006200.50047757
46Galactose metabolism_Homo sapiens_hsa000520.47529028
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47450448
48Fatty acid degradation_Homo sapiens_hsa000710.46315375
49Insulin resistance_Homo sapiens_hsa049310.46218319
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45754762
51Lysosome_Homo sapiens_hsa041420.45740884
52Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45554519
53One carbon pool by folate_Homo sapiens_hsa006700.42626722
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42372778
55Endometrial cancer_Homo sapiens_hsa052130.41942834
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.41404129
57Type I diabetes mellitus_Homo sapiens_hsa049400.41358881
58Tryptophan metabolism_Homo sapiens_hsa003800.39944904
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.39571910
60Legionellosis_Homo sapiens_hsa051340.38988932
61Caffeine metabolism_Homo sapiens_hsa002320.38669256
62mTOR signaling pathway_Homo sapiens_hsa041500.38003746
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35417003
64beta-Alanine metabolism_Homo sapiens_hsa004100.33761015
65Fatty acid biosynthesis_Homo sapiens_hsa000610.30884082
66Peroxisome_Homo sapiens_hsa041460.30123482
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.29004869
68Fatty acid metabolism_Homo sapiens_hsa012120.28950698
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27743886
70PPAR signaling pathway_Homo sapiens_hsa033200.27380256
71VEGF signaling pathway_Homo sapiens_hsa043700.27103251
72Cocaine addiction_Homo sapiens_hsa050300.26006962
73Prostate cancer_Homo sapiens_hsa052150.25674513
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.25304777
75Nitrogen metabolism_Homo sapiens_hsa009100.24416006
76Hepatitis C_Homo sapiens_hsa051600.23883821
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.23670360
78Tight junction_Homo sapiens_hsa045300.23132825
79Thyroid hormone synthesis_Homo sapiens_hsa049180.23024678
80Regulation of autophagy_Homo sapiens_hsa041400.22314072
81Estrogen signaling pathway_Homo sapiens_hsa049150.21628997
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.21307231
83AMPK signaling pathway_Homo sapiens_hsa041520.20987162
84ABC transporters_Homo sapiens_hsa020100.20892021
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20597745
86Prolactin signaling pathway_Homo sapiens_hsa049170.20368283
87Insulin signaling pathway_Homo sapiens_hsa049100.20129865
88Arginine biosynthesis_Homo sapiens_hsa002200.19363639
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.19188500
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.18619394
91Bladder cancer_Homo sapiens_hsa052190.18351884
92Fructose and mannose metabolism_Homo sapiens_hsa000510.18343402
93Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.17439941
94Ovarian steroidogenesis_Homo sapiens_hsa049130.17340129
95Adherens junction_Homo sapiens_hsa045200.17327790
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17307054
97Ether lipid metabolism_Homo sapiens_hsa005650.16695911
98Glutathione metabolism_Homo sapiens_hsa004800.16321784
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.16214345
100Glucagon signaling pathway_Homo sapiens_hsa049220.16059499
101Arachidonic acid metabolism_Homo sapiens_hsa005900.15852435
102Toxoplasmosis_Homo sapiens_hsa051450.15061750
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14912398
104Pancreatic cancer_Homo sapiens_hsa052120.13593967
105* Metabolic pathways_Homo sapiens_hsa011000.13404376
106Gastric acid secretion_Homo sapiens_hsa049710.13074194
107Carbon metabolism_Homo sapiens_hsa012000.12733028
108Lysine degradation_Homo sapiens_hsa003100.12428801
109Bile secretion_Homo sapiens_hsa049760.10980334
110Vitamin B6 metabolism_Homo sapiens_hsa007500.09651091
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.09540343
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08971661
113Non-small cell lung cancer_Homo sapiens_hsa052230.08815361
114Calcium signaling pathway_Homo sapiens_hsa040200.07743943
115Sulfur relay system_Homo sapiens_hsa041220.07636291
116Cholinergic synapse_Homo sapiens_hsa047250.06865008
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.06618128
118Thyroid cancer_Homo sapiens_hsa052160.06364764
119Ras signaling pathway_Homo sapiens_hsa040140.06178338
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.05219542
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.04143455
122Jak-STAT signaling pathway_Homo sapiens_hsa046300.03790489
123ErbB signaling pathway_Homo sapiens_hsa040120.00024620
124FoxO signaling pathway_Homo sapiens_hsa04068-0.0350427
125Butanoate metabolism_Homo sapiens_hsa00650-0.0343149
126Sphingolipid metabolism_Homo sapiens_hsa00600-0.0322013
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0260062
128Endocytosis_Homo sapiens_hsa04144-0.0241121
129Complement and coagulation cascades_Homo sapiens_hsa04610-0.0099321
130Chronic myeloid leukemia_Homo sapiens_hsa05220-0.0006234
131GnRH signaling pathway_Homo sapiens_hsa04912-0.0005736

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