CECR7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)7.90999542
2axonemal dynein complex assembly (GO:0070286)6.34367318
3cilium movement (GO:0003341)5.86962168
4motile cilium assembly (GO:0044458)5.67340581
5epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.65746944
6epithelial cilium movement (GO:0003351)5.11010360
7axoneme assembly (GO:0035082)4.71964643
8photoreceptor cell maintenance (GO:0045494)3.66024996
9cilium organization (GO:0044782)3.53016578
10cilium assembly (GO:0042384)3.49492439
11tryptophan catabolic process (GO:0006569)3.46456180
12indole-containing compound catabolic process (GO:0042436)3.46456180
13indolalkylamine catabolic process (GO:0046218)3.46456180
14neural tube formation (GO:0001841)3.32834362
15indolalkylamine metabolic process (GO:0006586)3.31350436
16regulation of cilium movement (GO:0003352)3.28841090
17intraciliary transport (GO:0042073)3.27788394
18monoubiquitinated protein deubiquitination (GO:0035520)3.27238602
19ventricular system development (GO:0021591)3.25292857
20detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.21870999
21signal peptide processing (GO:0006465)3.16905916
22regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13602533
23regulation of hippo signaling (GO:0035330)3.12006281
24one-carbon compound transport (GO:0019755)3.08835538
25microtubule polymerization or depolymerization (GO:0031109)3.05985095
26cilium morphogenesis (GO:0060271)3.04143147
27detection of light stimulus involved in sensory perception (GO:0050962)3.02671350
28detection of light stimulus involved in visual perception (GO:0050908)3.02671350
29protein localization to cilium (GO:0061512)3.01971358
30cellular component assembly involved in morphogenesis (GO:0010927)3.01434352
31benzene-containing compound metabolic process (GO:0042537)2.96745093
32left/right axis specification (GO:0070986)2.96643737
33microtubule bundle formation (GO:0001578)2.94849293
34establishment of protein localization to Golgi (GO:0072600)2.91686982
35response to nitrosative stress (GO:0051409)2.90536353
36retinal cone cell development (GO:0046549)2.90505574
37DNA methylation involved in gamete generation (GO:0043046)2.88054194
38sphingoid metabolic process (GO:0046519)2.85536012
39negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84161952
40sperm motility (GO:0030317)2.81153019
41tryptophan metabolic process (GO:0006568)2.77653215
42membrane depolarization during action potential (GO:0086010)2.76459186
43cellular response to sterol (GO:0036315)2.76267060
44reflex (GO:0060004)2.76044640
45kynurenine metabolic process (GO:0070189)2.75592302
46regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.75549686
47tachykinin receptor signaling pathway (GO:0007217)2.69453178
48UDP-N-acetylglucosamine metabolic process (GO:0006047)2.66821671
49centriole assembly (GO:0098534)2.66663612
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.65979904
51protein K48-linked deubiquitination (GO:0071108)2.65857055
52cellular ketone body metabolic process (GO:0046950)2.64877106
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.64768139
54regulation of collateral sprouting (GO:0048670)2.64438587
55multicellular organism reproduction (GO:0032504)2.62221745
56central nervous system neuron axonogenesis (GO:0021955)2.57371975
57indole-containing compound metabolic process (GO:0042430)2.57346570
58androgen biosynthetic process (GO:0006702)2.56365330
59gamma-aminobutyric acid transport (GO:0015812)2.56272020
60protein K11-linked deubiquitination (GO:0035871)2.54348730
61glycosphingolipid biosynthetic process (GO:0006688)2.54066412
62regulation of skeletal muscle contraction (GO:0014819)2.53115843
63serotonin metabolic process (GO:0042428)2.51249598
64proline transport (GO:0015824)2.50672530
65sialylation (GO:0097503)2.50226480
66regulation of pigment cell differentiation (GO:0050932)2.49778345
67thyroid hormone metabolic process (GO:0042403)2.49053866
68regulation of sarcomere organization (GO:0060297)2.47124464
69synaptic vesicle docking involved in exocytosis (GO:0016081)2.44080113
70positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.43905838
71positive regulation of developmental pigmentation (GO:0048087)2.42761693
72snRNA transcription (GO:0009301)2.41808662
73oxidative demethylation (GO:0070989)2.40917553
74acrosome reaction (GO:0007340)2.40568880
75ketone body metabolic process (GO:1902224)2.39477688
76left/right pattern formation (GO:0060972)2.38285548
77behavioral response to ethanol (GO:0048149)2.37881317
78sensory perception of smell (GO:0007608)2.37682230
79protein polyglutamylation (GO:0018095)2.37148819
80detection of mechanical stimulus involved in sensory perception (GO:0050974)2.36819084
81piRNA metabolic process (GO:0034587)2.35109564
82centriole replication (GO:0007099)2.35053037
83neuronal action potential propagation (GO:0019227)2.32991935
84L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.32837569
85vitamin transmembrane transport (GO:0035461)2.32338539
86righting reflex (GO:0060013)2.31564905
87negative regulation of translation, ncRNA-mediated (GO:0040033)2.31102952
88regulation of translation, ncRNA-mediated (GO:0045974)2.31102952
89negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.31102952
90protein K63-linked deubiquitination (GO:0070536)2.30981672
91lipid translocation (GO:0034204)2.30970629
92phospholipid translocation (GO:0045332)2.30970629
93dicarboxylic acid catabolic process (GO:0043649)2.30478747
94spinal cord motor neuron differentiation (GO:0021522)2.30444640
95interkinetic nuclear migration (GO:0022027)2.29678121
96lateral ventricle development (GO:0021670)2.28658425
97L-fucose metabolic process (GO:0042354)2.27110768
98L-fucose catabolic process (GO:0042355)2.27110768
99fucose catabolic process (GO:0019317)2.27110768
100presynaptic membrane assembly (GO:0097105)2.26800125

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.56269959
2VDR_22108803_ChIP-Seq_LS180_Human2.99908087
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.79484979
4IGF1R_20145208_ChIP-Seq_DFB_Human2.79087641
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.55927016
6ZNF274_21170338_ChIP-Seq_K562_Hela2.48563973
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.44603042
8EZH2_22144423_ChIP-Seq_EOC_Human2.39386603
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26347133
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26113627
11AR_21572438_ChIP-Seq_LNCaP_Human2.19690433
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.19087541
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.16150615
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15566902
15AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.05907669
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05494890
17P300_19829295_ChIP-Seq_ESCs_Human2.04443657
18SMAD4_21799915_ChIP-Seq_A2780_Human2.03144502
19STAT3_23295773_ChIP-Seq_U87_Human2.01848187
20TAF15_26573619_Chip-Seq_HEK293_Human2.01203705
21ER_23166858_ChIP-Seq_MCF-7_Human1.91705581
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.87093701
23PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.86460357
24SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.78887543
25PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73753054
26TCF4_23295773_ChIP-Seq_U87_Human1.73599804
27DROSHA_22980978_ChIP-Seq_HELA_Human1.71459608
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.69658833
29FUS_26573619_Chip-Seq_HEK293_Human1.68000342
30NR3C1_21868756_ChIP-Seq_MCF10A_Human1.67406856
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.61072339
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60976031
33CBP_20019798_ChIP-Seq_JUKART_Human1.60976031
34BCAT_22108803_ChIP-Seq_LS180_Human1.60573028
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59753622
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.59589925
37POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.59153772
38TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59153772
39EWS_26573619_Chip-Seq_HEK293_Human1.57497303
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56933565
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54992440
42AR_25329375_ChIP-Seq_VCAP_Human1.53763823
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53736421
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52291675
45RUNX2_22187159_ChIP-Seq_PCA_Human1.47176518
46AHR_22903824_ChIP-Seq_MCF-7_Human1.45941425
47SMAD4_21741376_ChIP-Seq_EPCs_Human1.42916615
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.42275059
49KLF5_20875108_ChIP-Seq_MESCs_Mouse1.41116342
50SMAD3_21741376_ChIP-Seq_HESCs_Human1.39874198
51PRDM14_20953172_ChIP-Seq_ESCs_Human1.39431110
52TCF4_22108803_ChIP-Seq_LS180_Human1.39020003
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38394658
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.35992653
55TP53_16413492_ChIP-PET_HCT116_Human1.35717996
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35439610
57SMAD4_21741376_ChIP-Seq_HESCs_Human1.34743002
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.33683341
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28906670
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27189469
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23634126
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.23571374
63REST_21632747_ChIP-Seq_MESCs_Mouse1.23293892
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.21124812
65TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19944669
66FOXM1_26456572_ChIP-Seq_MCF-7_Human1.18793205
67EZH2_27294783_Chip-Seq_NPCs_Mouse1.18021694
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16502686
69SOX2_19829295_ChIP-Seq_ESCs_Human1.15173985
70NANOG_19829295_ChIP-Seq_ESCs_Human1.15173985
71TBL1_22424771_ChIP-Seq_293T_Human1.14550589
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.14005541
73TP53_18474530_ChIP-ChIP_U2OS_Human1.13974186
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13019464
75CDX2_22108803_ChIP-Seq_LS180_Human1.12151395
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.11977761
77ESR1_20079471_ChIP-ChIP_T-47D_Human1.11689459
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.11679002
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10150259
80EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07611309
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06013431
82RXR_22108803_ChIP-Seq_LS180_Human1.05055707
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.04951483
84SMAD3_21741376_ChIP-Seq_ESCs_Human1.04384799
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04302571
86AR_19668381_ChIP-Seq_PC3_Human1.04126597
87FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04024513
88E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.03796569
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.03016183
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02884679
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02884679
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.01751104
93PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99493552
94KDM2B_26808549_Chip-Seq_REH_Human0.98857683
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98481181
96WDR5_24793694_ChIP-Seq_LNCAP_Human0.97617762
97NFYB_21822215_ChIP-Seq_K562_Human0.97179187
98E2F1_18555785_Chip-Seq_ESCs_Mouse0.97072128
99CRX_20693478_ChIP-Seq_RETINA_Mouse0.96844008
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96583983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.58145642
2MP0003195_calcinosis3.10088300
3MP0003136_yellow_coat_color2.96795892
4MP0003890_abnormal_embryonic-extraembry2.79332843
5MP0001984_abnormal_olfaction2.58570633
6MP0005171_absent_coat_pigmentation2.57108413
7MP0002653_abnormal_ependyma_morphology2.55534601
8MP0001968_abnormal_touch/_nociception2.53542493
9MP0002736_abnormal_nociception_after2.49451888
10MP0002102_abnormal_ear_morphology2.47898233
11MP0009046_muscle_twitch2.45463026
12MP0005551_abnormal_eye_electrophysiolog2.28529128
13MP0001501_abnormal_sleep_pattern2.23448376
14MP0004043_abnormal_pH_regulation2.13569014
15MP0002735_abnormal_chemical_nociception2.08423390
16MP0001486_abnormal_startle_reflex1.98659338
17MP0009745_abnormal_behavioral_response1.94354408
18MP0003646_muscle_fatigue1.90311262
19MP0003880_abnormal_central_pattern1.86620482
20MP0005253_abnormal_eye_physiology1.79050275
21MP0001485_abnormal_pinna_reflex1.75319782
22MP0003635_abnormal_synaptic_transmissio1.73433193
23MP0005646_abnormal_pituitary_gland1.71725912
24MP0004859_abnormal_synaptic_plasticity1.71491495
25MP0008057_abnormal_DNA_replication1.70638662
26MP0002272_abnormal_nervous_system1.70473581
27MP0000372_irregular_coat_pigmentation1.69468972
28MP0005174_abnormal_tail_pigmentation1.61289255
29MP0002572_abnormal_emotion/affect_behav1.60373513
30MP0003045_fibrosis1.55110506
31MP0002064_seizures1.53160371
32MP0004133_heterotaxia1.50992101
33MP0004147_increased_porphyrin_level1.50120860
34MP0002837_dystrophic_cardiac_calcinosis1.48264186
35MP0000383_abnormal_hair_follicle1.43855732
36MP0008872_abnormal_physiological_respon1.41963624
37MP0006276_abnormal_autonomic_nervous1.40543746
38MP0005410_abnormal_fertilization1.39634467
39MP0004215_abnormal_myocardial_fiber1.36718275
40MP0002067_abnormal_sensory_capabilities1.33223340
41MP0008004_abnormal_stomach_pH1.32512984
42MP0003698_abnormal_male_reproductive1.31053814
43MP0002168_other_aberrant_phenotype1.28772648
44MP0000015_abnormal_ear_pigmentation1.28582829
45MP0003878_abnormal_ear_physiology1.27678019
46MP0005377_hearing/vestibular/ear_phenot1.27678019
47MP0001970_abnormal_pain_threshold1.26855965
48MP0002734_abnormal_mechanical_nocicepti1.25899838
49MP0005423_abnormal_somatic_nervous1.24411973
50MP0002063_abnormal_learning/memory/cond1.23577384
51MP0008875_abnormal_xenobiotic_pharmacok1.23442038
52MP0001986_abnormal_taste_sensitivity1.23087621
53MP0002557_abnormal_social/conspecific_i1.22709379
54MP0010386_abnormal_urinary_bladder1.21787061
55MP0002229_neurodegeneration1.20048419
56MP0005386_behavior/neurological_phenoty1.17977271
57MP0004924_abnormal_behavior1.17977271
58MP0006072_abnormal_retinal_apoptosis1.16568554
59MP0008995_early_reproductive_senescence1.13128700
60MP0004085_abnormal_heartbeat1.12952564
61MP0006054_spinal_hemorrhage1.09380367
62MP0000427_abnormal_hair_cycle1.07999233
63MP0008877_abnormal_DNA_methylation1.06886012
64MP0003950_abnormal_plasma_membrane1.02890462
65MP0005394_taste/olfaction_phenotype1.01320394
66MP0005499_abnormal_olfactory_system1.01320394
67MP0004145_abnormal_muscle_electrophysio1.00258591
68MP0001963_abnormal_hearing_physiology0.99243971
69MP0001929_abnormal_gametogenesis0.98971301
70MP0002090_abnormal_vision0.98836491
71MP0000631_abnormal_neuroendocrine_gland0.98357458
72MP0005075_abnormal_melanosome_morpholog0.97613886
73MP0003633_abnormal_nervous_system0.96917002
74MP0002638_abnormal_pupillary_reflex0.95430473
75MP0003119_abnormal_digestive_system0.95369163
76MP0005670_abnormal_white_adipose0.94201798
77MP0005395_other_phenotype0.93834058
78MP0004885_abnormal_endolymph0.90452492
79MP0003879_abnormal_hair_cell0.90287720
80MP0002938_white_spotting0.89711395
81MP0002733_abnormal_thermal_nociception0.88789856
82MP0003137_abnormal_impulse_conducting0.88755549
83MP0005645_abnormal_hypothalamus_physiol0.87833704
84MP0003631_nervous_system_phenotype0.87643255
85MP0002882_abnormal_neuron_morphology0.86078648
86MP0004381_abnormal_hair_follicle0.84264304
87MP0002138_abnormal_hepatobiliary_system0.84228007
88MP0002160_abnormal_reproductive_system0.83871532
89MP0009780_abnormal_chondrocyte_physiolo0.83870681
90MP0002752_abnormal_somatic_nervous0.82804112
91MP0002095_abnormal_skin_pigmentation0.82200123
92MP0005220_abnormal_exocrine_pancreas0.79699438
93MP0010678_abnormal_skin_adnexa0.79366371
94MP0005167_abnormal_blood-brain_barrier0.78738088
95MP0004270_analgesia0.77682145
96MP0003632_abnormal_nervous_system0.76540108
97MP0008569_lethality_at_weaning0.76014895
98MP0004142_abnormal_muscle_tone0.74594916
99MP0001324_abnormal_eye_pigmentation0.74497892
100MP0002132_abnormal_respiratory_system0.73998323

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)5.94705152
2Absent/shortened dynein arms (HP:0200106)5.94705152
3Abnormal ciliary motility (HP:0012262)5.94560274
4Abnormal respiratory epithelium morphology (HP:0012253)5.71734414
5Abnormal respiratory motile cilium morphology (HP:0005938)5.71734414
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.70130023
7Abnormal respiratory motile cilium physiology (HP:0012261)5.61602457
8Rhinitis (HP:0012384)4.79678318
9Pancreatic cysts (HP:0001737)4.22243095
10True hermaphroditism (HP:0010459)3.93422147
11Pancreatic fibrosis (HP:0100732)3.88719118
12Gaze-evoked nystagmus (HP:0000640)3.59144276
13Bronchiectasis (HP:0002110)3.56461020
14Genetic anticipation (HP:0003743)3.50131899
15Cystic liver disease (HP:0006706)3.42338706
16Chronic bronchitis (HP:0004469)3.32565916
17Progressive cerebellar ataxia (HP:0002073)3.29456343
18Nephronophthisis (HP:0000090)3.28915064
19Tubulointerstitial nephritis (HP:0001970)3.27371122
20Chronic hepatic failure (HP:0100626)3.26382435
21Abnormality of midbrain morphology (HP:0002418)3.20787955
22Molar tooth sign on MRI (HP:0002419)3.20787955
23Hyperventilation (HP:0002883)3.09330859
24Abnormality of the renal medulla (HP:0100957)3.08198937
25Absent speech (HP:0001344)2.91674027
26Febrile seizures (HP:0002373)2.82414757
27Medial flaring of the eyebrow (HP:0010747)2.76327579
28Attenuation of retinal blood vessels (HP:0007843)2.71120236
29Central scotoma (HP:0000603)2.63842871
30Abnormality of the renal cortex (HP:0011035)2.59438907
31Clumsiness (HP:0002312)2.59429321
32Broad-based gait (HP:0002136)2.57771731
33Gait imbalance (HP:0002141)2.49530072
34Focal motor seizures (HP:0011153)2.46416136
35Congenital hepatic fibrosis (HP:0002612)2.46369669
36Focal seizures (HP:0007359)2.44728922
37Congenital primary aphakia (HP:0007707)2.43375406
38Occipital encephalocele (HP:0002085)2.41052672
39Nephrogenic diabetes insipidus (HP:0009806)2.37484232
40Anencephaly (HP:0002323)2.36772329
41Protruding tongue (HP:0010808)2.29573402
42Congenital stationary night blindness (HP:0007642)2.27512421
43Aplasia/Hypoplasia of the tongue (HP:0010295)2.26795371
44Postaxial foot polydactyly (HP:0001830)2.26178296
45Male pseudohermaphroditism (HP:0000037)2.22401122
46Infertility (HP:0000789)2.20125995
47Intestinal atresia (HP:0011100)2.20087244
48Bony spicule pigmentary retinopathy (HP:0007737)2.19999971
49Genital tract atresia (HP:0001827)2.15518923
50Sclerocornea (HP:0000647)2.09771945
51Abnormal drinking behavior (HP:0030082)2.08939906
52Polydipsia (HP:0001959)2.08939906
53Vaginal atresia (HP:0000148)2.08255256
54Widely spaced teeth (HP:0000687)2.08108846
55Tubulointerstitial abnormality (HP:0001969)2.05833782
56Decreased circulating renin level (HP:0003351)2.03302811
57Atonic seizures (HP:0010819)2.02722693
58Tubular atrophy (HP:0000092)1.99568624
59Abolished electroretinogram (ERG) (HP:0000550)1.98980553
60Male infertility (HP:0003251)1.97838270
61Decreased central vision (HP:0007663)1.94806771
62Inability to walk (HP:0002540)1.92668828
63Furrowed tongue (HP:0000221)1.90751564
64Aplasia/Hypoplasia of the tibia (HP:0005772)1.89264435
65Facial diplegia (HP:0001349)1.89241988
66Dialeptic seizures (HP:0011146)1.88768764
67Recurrent sinusitis (HP:0011108)1.87777937
68Cerebellar dysplasia (HP:0007033)1.87610506
69Poor coordination (HP:0002370)1.86346963
70Progressive inability to walk (HP:0002505)1.85880290
71Preaxial hand polydactyly (HP:0001177)1.84899609
72Hypoplastic labia majora (HP:0000059)1.83797755
73Fair hair (HP:0002286)1.83518320
74Abnormality of the ischium (HP:0003174)1.81628994
75Abnormality of macular pigmentation (HP:0008002)1.81504404
76Small hand (HP:0200055)1.79589886
77Congenital sensorineural hearing impairment (HP:0008527)1.79471775
78Postaxial hand polydactyly (HP:0001162)1.77558416
79Hypoplastic ischia (HP:0003175)1.76851793
80Abnormality of the labia majora (HP:0012881)1.76516607
81Cupped ear (HP:0000378)1.75638503
82Type II lissencephaly (HP:0007260)1.75459154
83Hip dysplasia (HP:0001385)1.75454623
84Dysmetric saccades (HP:0000641)1.73352458
85Scotoma (HP:0000575)1.71116962
86Chronic sinusitis (HP:0011109)1.68845850
87Highly arched eyebrow (HP:0002553)1.67682559
88Labial hypoplasia (HP:0000066)1.67045392
89Oculomotor apraxia (HP:0000657)1.66961553
90Postural instability (HP:0002172)1.66841127
91Retinal dysplasia (HP:0007973)1.66028949
92Generalized hypopigmentation of hair (HP:0011358)1.65875184
93Retinitis pigmentosa (HP:0000510)1.65798512
94Hypoplasia of the fovea (HP:0007750)1.65599447
95Aplasia/Hypoplasia of the fovea (HP:0008060)1.65599447
96Tented upper lip vermilion (HP:0010804)1.64770091
97Blue irides (HP:0000635)1.64329270
98Astigmatism (HP:0000483)1.64299318
99Short foot (HP:0001773)1.64255583
100Oligodactyly (hands) (HP:0001180)1.62762469

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.19679735
2ACVR1B3.45648637
3BMPR1B3.36024426
4LATS13.35443714
5STK38L2.45392116
6MAPK152.17126757
7PINK12.07276248
8MAPK131.82091559
9NTRK31.78104975
10CASK1.71306424
11ADRBK21.69023335
12INSRR1.67127551
13GRK11.66610645
14PRKD31.62366318
15WNK31.58420583
16AKT31.57150603
17TRIM281.45110763
18MKNK21.42583332
19BRD41.34843076
20PTK2B1.32996285
21EPHA41.30884677
22STK381.30157098
23ZAK1.27579402
24NUAK11.22153496
25MAP3K41.17952755
26DAPK21.12529061
27SGK21.08889268
28STK31.07815822
29TGFBR11.07611814
30FER1.06194528
31MARK11.03449526
32PIK3CG1.02356707
33TNIK1.02072167
34MAP4K21.00336262
35PRKAA20.98314178
36OBSCN0.98060146
37MAP3K70.97123696
38TNK20.94877919
39PDK20.94021861
40PLK20.93764848
41MARK30.90972611
42PRKCE0.90070467
43ADRBK10.89931982
44BRSK20.86487534
45MST40.85416606
46CAMK1G0.81864095
47PKN10.80483760
48FGFR20.80228909
49NLK0.79638046
50SGK2230.79271771
51SGK4940.79271771
52ERBB40.79007673
53PAK30.77361742
54OXSR10.76468764
55PRKCG0.71728912
56CSNK1A1L0.71371192
57PBK0.69115764
58CAMK10.65704452
59CDK30.65289794
60MAP3K20.63764672
61PRKAA10.63165993
62MELK0.63155506
63BCR0.58543868
64NEK60.58514103
65STK390.58319894
66ERBB30.57527540
67EIF2AK30.52932029
68CAMK2A0.52725282
69MYLK0.51528832
70CSNK1G10.51202401
71CAMK1D0.49309661
72PHKG20.47758003
73PHKG10.47758003
74PNCK0.46827746
75MAP2K70.46424979
76TEC0.45279753
77PRKCQ0.44100615
78PRKCH0.43937379
79CAMK40.43187901
80MKNK10.42922022
81ERBB20.42381257
82MAPKAPK30.41263572
83CSNK1G20.40936558
84CCNB10.39552781
85SGK10.39417940
86NEK20.39360105
87SIK20.38072160
88FLT30.37202238
89CSNK1D0.36622548
90TAOK30.36160507
91SGK30.35879077
92ROCK10.34909462
93PRKG10.34729244
94TRPM70.34667303
95PKN20.34054726
96MAP2K10.32163224
97RPS6KA30.31718086
98PRKACA0.31036658
99CSNK1A10.30964294
100ATM0.30055461

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.86519445
2Butanoate metabolism_Homo sapiens_hsa006502.67427367
3Phototransduction_Homo sapiens_hsa047442.31572789
4ABC transporters_Homo sapiens_hsa020102.15641613
5Taste transduction_Homo sapiens_hsa047422.14666674
6Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.12869588
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.08670275
8Olfactory transduction_Homo sapiens_hsa047402.05998303
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98678256
10Histidine metabolism_Homo sapiens_hsa003401.94886186
11Chemical carcinogenesis_Homo sapiens_hsa052041.82638855
12Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82478435
13Primary bile acid biosynthesis_Homo sapiens_hsa001201.79543358
14Nitrogen metabolism_Homo sapiens_hsa009101.77281835
15beta-Alanine metabolism_Homo sapiens_hsa004101.76819429
16Circadian entrainment_Homo sapiens_hsa047131.75117540
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66711707
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66489051
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63272821
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.60171140
21Glutamatergic synapse_Homo sapiens_hsa047241.59100194
22Calcium signaling pathway_Homo sapiens_hsa040201.59059621
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.58220422
24GABAergic synapse_Homo sapiens_hsa047271.55331532
25Tryptophan metabolism_Homo sapiens_hsa003801.53619090
26Morphine addiction_Homo sapiens_hsa050321.52174977
27Sphingolipid metabolism_Homo sapiens_hsa006001.49874226
28Linoleic acid metabolism_Homo sapiens_hsa005911.49845970
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.45565943
30Steroid hormone biosynthesis_Homo sapiens_hsa001401.43971693
31Dorso-ventral axis formation_Homo sapiens_hsa043201.42014828
32Salivary secretion_Homo sapiens_hsa049701.41940994
33Propanoate metabolism_Homo sapiens_hsa006401.40396422
34Serotonergic synapse_Homo sapiens_hsa047261.31786801
35Circadian rhythm_Homo sapiens_hsa047101.25769696
36Retinol metabolism_Homo sapiens_hsa008301.25758854
37Insulin secretion_Homo sapiens_hsa049111.24613136
38Lysine degradation_Homo sapiens_hsa003101.23515487
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19574699
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18987977
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12125468
42Glycerolipid metabolism_Homo sapiens_hsa005611.10314471
43Tyrosine metabolism_Homo sapiens_hsa003501.03222640
44Fanconi anemia pathway_Homo sapiens_hsa034601.00480865
45Vascular smooth muscle contraction_Homo sapiens_hsa042700.99938382
46Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.97676349
47Ovarian steroidogenesis_Homo sapiens_hsa049130.97651909
48Gastric acid secretion_Homo sapiens_hsa049710.97150556
49Fatty acid degradation_Homo sapiens_hsa000710.96706479
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96588725
51Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96277284
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95863426
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90263989
54Amphetamine addiction_Homo sapiens_hsa050310.89909002
55Ether lipid metabolism_Homo sapiens_hsa005650.88256373
56Maturity onset diabetes of the young_Homo sapiens_hsa049500.83003062
57Oxytocin signaling pathway_Homo sapiens_hsa049210.82584238
58cAMP signaling pathway_Homo sapiens_hsa040240.82184842
59Dopaminergic synapse_Homo sapiens_hsa047280.81477206
60Cholinergic synapse_Homo sapiens_hsa047250.80887906
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78643673
62Long-term depression_Homo sapiens_hsa047300.78055545
63Type II diabetes mellitus_Homo sapiens_hsa049300.75709638
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75347808
65Renin secretion_Homo sapiens_hsa049240.74266666
66Cocaine addiction_Homo sapiens_hsa050300.73573279
67Glycerophospholipid metabolism_Homo sapiens_hsa005640.70818381
68Peroxisome_Homo sapiens_hsa041460.70119402
69Regulation of autophagy_Homo sapiens_hsa041400.70115465
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70084525
71Fatty acid metabolism_Homo sapiens_hsa012120.66837052
72Selenocompound metabolism_Homo sapiens_hsa004500.64494127
73TGF-beta signaling pathway_Homo sapiens_hsa043500.64140849
74Glutathione metabolism_Homo sapiens_hsa004800.60489858
75Pancreatic secretion_Homo sapiens_hsa049720.60411563
76Phenylalanine metabolism_Homo sapiens_hsa003600.59061963
77Caffeine metabolism_Homo sapiens_hsa002320.57623609
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53738118
79Fatty acid biosynthesis_Homo sapiens_hsa000610.53573893
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.53098935
81Homologous recombination_Homo sapiens_hsa034400.52196902
82Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48264753
83Inositol phosphate metabolism_Homo sapiens_hsa005620.47267708
84Choline metabolism in cancer_Homo sapiens_hsa052310.45731404
85Synaptic vesicle cycle_Homo sapiens_hsa047210.44213027
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43739447
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43438780
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.42078199
89Vitamin digestion and absorption_Homo sapiens_hsa049770.41374550
90mTOR signaling pathway_Homo sapiens_hsa041500.41247998
91Arachidonic acid metabolism_Homo sapiens_hsa005900.40135948
92Hedgehog signaling pathway_Homo sapiens_hsa043400.40110024
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40104342
94Tight junction_Homo sapiens_hsa045300.40076824
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40015816
96Long-term potentiation_Homo sapiens_hsa047200.39553946
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38648278
98Basal transcription factors_Homo sapiens_hsa030220.37530030
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36280672
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.32343931

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