CECR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.72700135
2negative regulation of cell killing (GO:0031342)5.37957449
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.37957449
4negative regulation of interleukin-12 production (GO:0032695)5.08599741
5neutrophil activation involved in immune response (GO:0002283)5.04861182
6response to peptidoglycan (GO:0032494)5.02358212
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.96963142
8positive regulation by symbiont of host defense response (GO:0052509)4.91449671
9modulation by symbiont of host defense response (GO:0052031)4.91449671
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.91449671
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.91449671
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.91449671
13modulation by symbiont of host immune response (GO:0052553)4.91449671
14macrophage activation involved in immune response (GO:0002281)4.80133571
15detection of other organism (GO:0098543)4.50983582
16antigen processing and presentation of endogenous antigen (GO:0019883)4.43044787
17immunoglobulin mediated immune response (GO:0016064)4.29460226
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.25770824
19detection of bacterium (GO:0016045)4.24151585
20regulation of gamma-delta T cell activation (GO:0046643)4.20898151
21cellular extravasation (GO:0045123)3.98674602
22regulation of B cell receptor signaling pathway (GO:0050855)3.94752662
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.91414833
24positive regulation of mast cell activation (GO:0033005)3.74096423
25regulation of interferon-beta biosynthetic process (GO:0045357)3.72798288
26detection of external biotic stimulus (GO:0098581)3.72452224
27microglial cell activation (GO:0001774)3.66148782
28regulation of mast cell degranulation (GO:0043304)3.61059594
29detection of molecule of bacterial origin (GO:0032490)3.60562690
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.58518982
31granulocyte activation (GO:0036230)3.57946374
32neutrophil activation (GO:0042119)3.57900074
33myeloid cell activation involved in immune response (GO:0002275)3.54490596
34interferon-gamma-mediated signaling pathway (GO:0060333)3.51791160
35regulation of T cell tolerance induction (GO:0002664)3.51371198
36respiratory burst (GO:0045730)3.50670678
37macrophage activation (GO:0042116)3.50185507
38regulation of tolerance induction (GO:0002643)3.49056507
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.47138180
40regulation of gamma-delta T cell differentiation (GO:0045586)3.43590509
41negative regulation of T cell mediated immunity (GO:0002710)3.41794121
42response to muramyl dipeptide (GO:0032495)3.40326082
43positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38807452
44positive regulation of mast cell activation involved in immune response (GO:0033008)3.38189517
45positive regulation of mast cell degranulation (GO:0043306)3.38189517
46detection of biotic stimulus (GO:0009595)3.37548368
47leukocyte aggregation (GO:0070486)3.36659269
48type I interferon signaling pathway (GO:0060337)3.35220930
49cellular response to type I interferon (GO:0071357)3.35220930
50regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34511706
51positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.34010159
52regulation of mast cell activation involved in immune response (GO:0033006)3.32296688
53response to type I interferon (GO:0034340)3.32228891
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.30497153
55response to host immune response (GO:0052572)3.30497153
56regulation of mast cell activation (GO:0033003)3.30236900
57positive regulation of antigen processing and presentation (GO:0002579)3.30032340
58regulation of antigen processing and presentation (GO:0002577)3.29422438
59lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28680442
60regulation of leukocyte degranulation (GO:0043300)3.26993331
61regulation of myeloid leukocyte mediated immunity (GO:0002886)3.26051769
62negative regulation of leukocyte mediated immunity (GO:0002704)3.23712711
63B cell mediated immunity (GO:0019724)3.23192361
64T-helper 1 type immune response (GO:0042088)3.20556927
65negative regulation of erythrocyte differentiation (GO:0045647)3.17866920
66T cell migration (GO:0072678)3.14413483
67regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.11169810
68defense response to protozoan (GO:0042832)3.09555786
69negative regulation of cytokine production involved in immune response (GO:0002719)3.07810130
70positive regulation of cellular amide metabolic process (GO:0034250)3.04446434
71germinal center formation (GO:0002467)3.02602471
72positive regulation of B cell differentiation (GO:0045579)3.01781745
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.98523281
74positive regulation of tolerance induction (GO:0002645)2.98422393
75regulation of interferon-alpha production (GO:0032647)2.98410415
76positive regulation of type 2 immune response (GO:0002830)2.98360110
77activated T cell proliferation (GO:0050798)2.94740778
78response to host (GO:0075136)2.93128335
79response to host defenses (GO:0052200)2.93128335
80response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.93128335
81response to protozoan (GO:0001562)2.92913573
82production of molecular mediator involved in inflammatory response (GO:0002532)2.92254647
83antigen processing and presentation via MHC class Ib (GO:0002475)2.92098373
84positive thymic T cell selection (GO:0045059)2.91510668
85positive regulation of interferon-alpha production (GO:0032727)2.86425874
86negative thymic T cell selection (GO:0045060)2.85978592
87regulation of T-helper 2 cell differentiation (GO:0045628)2.84086724
88neutrophil mediated immunity (GO:0002446)2.84049296
89positive regulation of leukocyte degranulation (GO:0043302)2.82899849
90amino sugar catabolic process (GO:0046348)2.81468725
91positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.80938262
92negative regulation of innate immune response (GO:0045824)2.80085283
93negative regulation of interleukin-6 production (GO:0032715)2.79086076
94regulation of interleukin-8 biosynthetic process (GO:0045414)2.78420386
95myeloid dendritic cell activation (GO:0001773)2.77171411
96negative T cell selection (GO:0043383)2.76546151
97myeloid dendritic cell differentiation (GO:0043011)2.75900556
98myeloid leukocyte activation (GO:0002274)2.75026717
99regulation of regulated secretory pathway (GO:1903305)2.74973205
100regulation of interleukin-12 production (GO:0032655)2.73850953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.21967593
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.92895555
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.57541972
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.94137115
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.81533704
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57673074
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43013892
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.31675335
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.27911274
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06308121
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.91861246
12STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.74916593
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70222740
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.59491562
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.53200593
16RUNX_20019798_ChIP-Seq_JUKART_Human2.52334184
17SPI1_23127762_ChIP-Seq_K562_Human2.47858257
18VDR_24763502_ChIP-Seq_THP-1_Human2.45145982
19SPI1_23547873_ChIP-Seq_NB4_Human2.43511191
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.35809030
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.33258377
22STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24501144
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.23674328
24VDR_24787735_ChIP-Seq_THP-1_Human2.23024305
25VDR_21846776_ChIP-Seq_THP-1_Human2.20937312
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.18108506
27SCL_19346495_ChIP-Seq_HPC-7_Human2.12640643
28* MYB_26560356_Chip-Seq_TH2_Human2.07900384
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.05801450
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.04335403
31E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01805190
32RUNX1_22412390_ChIP-Seq_EML_Mouse1.94151439
33MAF_26560356_Chip-Seq_TH1_Human1.93616574
34EGR1_19374776_ChIP-ChIP_THP-1_Human1.81249321
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76468930
36UTX_26944678_Chip-Seq_JUKART_Human1.68558049
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.64766437
38MYB_26560356_Chip-Seq_TH1_Human1.63949730
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.60830554
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60734043
41CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.59696227
42LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.58935442
43GATA3_27048872_Chip-Seq_THYMUS_Human1.55984487
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55655320
45PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54246674
46PU_27001747_Chip-Seq_BMDM_Mouse1.46790296
47TCF7_22412390_ChIP-Seq_EML_Mouse1.42304282
48MYC_22102868_ChIP-Seq_BL_Human1.41851271
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.40123025
50GATA1_19941827_ChIP-Seq_MEL_Mouse1.39555433
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39159283
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.37141933
53KDM2B_26808549_Chip-Seq_DND41_Human1.34658409
54MAF_26560356_Chip-Seq_TH2_Human1.32817806
55CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.32641775
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31979219
57CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.31970864
58CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.28073245
59GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27288392
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24371296
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.23898488
62GATA3_26560356_Chip-Seq_TH2_Human1.23405829
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21109770
64SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20833919
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20339908
66GATA1_19941826_ChIP-Seq_K562_Human1.19490907
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.19096864
68* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17629902
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16860677
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15934703
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15031827
72GATA1_22025678_ChIP-Seq_K562_Human1.13738338
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12188799
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11499655
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.08974931
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07548616
77GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04894407
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03957612
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03421903
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02465810
81LXR_22292898_ChIP-Seq_THP-1_Human1.02093660
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97086923
83GATA2_21666600_ChIP-Seq_HMVEC_Human0.94904430
84ELK3_25401928_ChIP-Seq_HUVEC_Human0.91850669
85BCL6_27268052_Chip-Seq_Bcells_Human0.89739118
86GATA2_19941826_ChIP-Seq_K562_Human0.89095223
87PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88626536
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88406605
89STAT1_20625510_ChIP-Seq_HELA_Human0.86842116
90BCOR_27268052_Chip-Seq_Bcells_Human0.84172887
91KDM2B_26808549_Chip-Seq_JURKAT_Human0.83989679
92* SMRT_27268052_Chip-Seq_Bcells_Human0.78969771
93GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76655819
94SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76608307
95STAT6_21828071_ChIP-Seq_BEAS2B_Human0.76107990
96TFEB_21752829_ChIP-Seq_HELA_Human0.75381643
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.73077978
98SPI1_20517297_ChIP-Seq_HL60_Human0.67721950
99* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66712556
100SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.66682091

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation4.27209565
2MP0003724_increased_susceptibility_to4.23041237
3MP0001835_abnormal_antigen_presentation3.86999092
4MP0003436_decreased_susceptibility_to3.73630143
5MP0006082_CNS_inflammation3.68741289
6MP0005671_abnormal_response_to3.38465095
7MP0002419_abnormal_innate_immunity3.06515103
8MP0009785_altered_susceptibility_to2.97199051
9MP0005058_abnormal_lysosome_morphology2.91731862
10MP0001790_abnormal_immune_system2.88931922
11MP0005387_immune_system_phenotype2.88931922
12MP0005000_abnormal_immune_tolerance2.85032161
13MP0005025_abnormal_response_to2.84313799
14MP0002148_abnormal_hypersensitivity_rea2.82530008
15MP0001800_abnormal_humoral_immune2.70702926
16MP0003172_abnormal_lysosome_physiology2.70284729
17MP0000685_abnormal_immune_system2.56034741
18MP0002452_abnormal_antigen_presenting2.53778002
19MP0003300_gastrointestinal_ulcer2.51803065
20MP0002723_abnormal_immune_serum2.49226785
21MP0002420_abnormal_adaptive_immunity2.30659928
22MP0001819_abnormal_immune_cell2.29519869
23MP0001533_abnormal_skeleton_physiology2.08494722
24MP0002405_respiratory_system_inflammati1.99753678
25MP0010155_abnormal_intestine_physiology1.87453029
26MP0001845_abnormal_inflammatory_respons1.85311846
27MP0003191_abnormal_cellular_cholesterol1.81834669
28MP0005464_abnormal_platelet_physiology1.81018562
29MP0004510_myositis1.75711184
30MP0003075_altered_response_to1.73787013
31MP0003690_abnormal_glial_cell1.73165993
32MP0000716_abnormal_immune_system1.68284815
33MP0009764_decreased_sensitivity_to1.68002348
34MP0004947_skin_inflammation1.67850843
35MP0009278_abnormal_bone_marrow1.64452184
36MP0009333_abnormal_splenocyte_physiolog1.61911391
37MP0003763_abnormal_thymus_physiology1.60228360
38MP0005310_abnormal_salivary_gland1.59699602
39MP0000604_amyloidosis1.58708343
40MP0008469_abnormal_protein_level1.55952768
41MP0002998_abnormal_bone_remodeling1.54572767
42MP0003828_pulmonary_edema1.53887600
43MP0009840_abnormal_foam_cell1.52417479
44MP0002398_abnormal_bone_marrow1.52411572
45MP0000343_altered_response_to1.50778176
46MP0008004_abnormal_stomach_pH1.40365570
47MP0005451_abnormal_body_composition1.39158431
48MP0000689_abnormal_spleen_morphology1.38923097
49MP0001853_heart_inflammation1.37374818
50MP0005397_hematopoietic_system_phenotyp1.31292615
51MP0001545_abnormal_hematopoietic_system1.31292615
52MP0005166_decreased_susceptibility_to1.27289160
53MP0002429_abnormal_blood_cell1.27145601
54MP0002722_abnormal_immune_system1.26307376
55MP0000858_altered_metastatic_potential1.24519725
56MP0003183_abnormal_peptide_metabolism1.21401433
57MP0008260_abnormal_autophagy1.21180983
58MP0003448_altered_tumor_morphology1.19895754
59MP0004883_abnormal_blood_vessel1.18747867
60MP0000465_gastrointestinal_hemorrhage1.12231508
61MP0003866_abnormal_defecation1.10956752
62MP0002277_abnormal_respiratory_mucosa1.06034512
63MP0002132_abnormal_respiratory_system1.04929567
64MP0002254_reproductive_system_inflammat1.00155480
65MP0001851_eye_inflammation0.99224682
66MP0005164_abnormal_response_to0.98903013
67MP0002139_abnormal_hepatobiliary_system0.96336781
68MP0000703_abnormal_thymus_morphology0.90946776
69MP0009763_increased_sensitivity_to0.90457890
70MP0001663_abnormal_digestive_system0.87958825
71MP0005167_abnormal_blood-brain_barrier0.86862513
72MP0003656_abnormal_erythrocyte_physiolo0.84337825
73MP0003806_abnormal_nucleotide_metabolis0.83992434
74MP0000920_abnormal_myelination0.81965494
75MP0005390_skeleton_phenotype0.81159611
76MP0002138_abnormal_hepatobiliary_system0.79168556
77MP0002166_altered_tumor_susceptibility0.77940995
78MP0002933_joint_inflammation0.74038625
79MP0009765_abnormal_xenobiotic_induced0.70701325
80MP0006054_spinal_hemorrhage0.68920434
81MP0000569_abnormal_digit_pigmentation0.68859166
82MP0003795_abnormal_bone_structure0.67245604
83MP0000249_abnormal_blood_vessel0.65896723
84MP0001873_stomach_inflammation0.65180168
85MP0002693_abnormal_pancreas_physiology0.64978575
86MP0002332_abnormal_exercise_endurance0.64813330
87MP0005365_abnormal_bile_salt0.64528292
88MP0003329_amyloid_beta_deposits0.64463537
89MP0001986_abnormal_taste_sensitivity0.64304476
90MP0003453_abnormal_keratinocyte_physiol0.63511197
91MP0004381_abnormal_hair_follicle0.63269461
92MP0000015_abnormal_ear_pigmentation0.60116074
93MP0005075_abnormal_melanosome_morpholog0.57880376
94MP0008874_decreased_physiological_sensi0.57686673
95MP0003091_abnormal_cell_migration0.56637630
96MP0001542_abnormal_bone_strength0.51277062
97MP0004808_abnormal_hematopoietic_stem0.51105618
98MP0005535_abnormal_body_temperature0.51073139
99MP0003045_fibrosis0.50174081
100MP0000490_abnormal_crypts_of0.49981059

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.78037052
2Recurrent bacterial skin infections (HP:0005406)5.74641795
3Abnormality of macrophages (HP:0004311)5.73839935
4Recurrent abscess formation (HP:0002722)5.56505550
5Abnormality of glycolipid metabolism (HP:0010969)5.48921895
6Abnormality of liposaccharide metabolism (HP:0010968)5.48921895
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.48921895
8Myositis (HP:0100614)4.87185130
9Orchitis (HP:0100796)4.68404471
10Retrobulbar optic neuritis (HP:0100654)4.62882135
11Optic neuritis (HP:0100653)4.62882135
12Recurrent gram-negative bacterial infections (HP:0005420)4.55790719
13Stomatitis (HP:0010280)4.55602977
14Increased cerebral lipofuscin (HP:0011813)4.41576704
15Vacuolated lymphocytes (HP:0001922)4.21628690
16Mediastinal lymphadenopathy (HP:0100721)3.87749403
17Elevated erythrocyte sedimentation rate (HP:0003565)3.80752457
18Systemic lupus erythematosus (HP:0002725)3.78521150
19Recurrent skin infections (HP:0001581)3.72730942
20Loss of speech (HP:0002371)3.71533911
21Recurrent fungal infections (HP:0002841)3.67345366
22Dysostosis multiplex (HP:0000943)3.63294965
23Increased neuronal autofluorescent lipopigment (HP:0002074)3.51621548
24Chronic obstructive pulmonary disease (HP:0006510)3.45892257
25Obstructive lung disease (HP:0006536)3.45892257
26Spontaneous hematomas (HP:0007420)3.33720513
27Meningitis (HP:0001287)3.31269869
28Disinhibition (HP:0000734)3.31068569
29Recurrent cutaneous fungal infections (HP:0011370)3.28422138
30Chronic mucocutaneous candidiasis (HP:0002728)3.28422138
31Keratoconjunctivitis sicca (HP:0001097)3.21163948
32Vasculitis (HP:0002633)3.15724318
33T lymphocytopenia (HP:0005403)3.12354514
34Pulmonary infiltrates (HP:0002113)3.08982876
35Gastrointestinal infarctions (HP:0005244)3.04624368
36Hemoptysis (HP:0002105)3.04296284
37Encephalitis (HP:0002383)3.03835778
38Keratoconjunctivitis (HP:0001096)3.02448285
39Gingivitis (HP:0000230)2.97664164
40Amyloidosis (HP:0011034)2.96358208
41Abnormal delayed hypersensitivity skin test (HP:0002963)2.92654360
42Abnormality of T cell number (HP:0011839)2.90070891
43Recurrent viral infections (HP:0004429)2.87467344
44Mutism (HP:0002300)2.84498918
45Autoimmune thrombocytopenia (HP:0001973)2.83302857
46Hematochezia (HP:0002573)2.81584002
47Abnormality of mucopolysaccharide metabolism (HP:0011020)2.81383235
48Abnormality of polysaccharide metabolism (HP:0011012)2.81383235
49Abnormality of glycosaminoglycan metabolism (HP:0004371)2.81383235
50Urticaria (HP:0001025)2.75801109
51Mucopolysacchariduria (HP:0008155)2.68651028
52Urinary glycosaminoglycan excretion (HP:0003541)2.68651028
53Increased IgE level (HP:0003212)2.66098043
54Chest pain (HP:0100749)2.47774179
55Pustule (HP:0200039)2.44808018
56Arterial thrombosis (HP:0004420)2.43203961
57Pulmonary embolism (HP:0002204)2.43154918
58Episodic fever (HP:0001954)2.40451827
59Prolonged bleeding time (HP:0003010)2.39603705
60Petechiae (HP:0000967)2.38056827
61Increased IgM level (HP:0003496)2.36071404
62Increased serum ferritin (HP:0003281)2.34002431
63* Leukocytosis (HP:0001974)2.32023737
64Gangrene (HP:0100758)2.30368404
65Gingival bleeding (HP:0000225)2.29177590
66Polyneuropathy (HP:0001271)2.29144551
67Inflammation of the large intestine (HP:0002037)2.25753300
68Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.21008880
69Epistaxis (HP:0000421)2.20788826
70Anorexia (HP:0002039)2.20747712
71Cellulitis (HP:0100658)2.16145035
72Abnormality of T cells (HP:0002843)2.15737953
73Abnormality of the pleura (HP:0002103)2.15581108
74Malnutrition (HP:0004395)2.15154932
75Colitis (HP:0002583)2.13842091
76Gastrointestinal inflammation (HP:0004386)2.12819024
77Panhypogammaglobulinemia (HP:0003139)2.11280859
78Neuronal loss in central nervous system (HP:0002529)2.10881214
79Hepatosplenomegaly (HP:0001433)2.09961160
80Glomerulonephritis (HP:0000099)2.08264661
81Hypergammaglobulinemia (HP:0010702)2.06255925
82Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.04816547
83Abnormality of iron homeostasis (HP:0011031)2.04454223
84Osteomyelitis (HP:0002754)2.04299667
85Abnormality of the vasculature of the conjunctiva (HP:0008054)2.00998491
86* Purpura (HP:0000979)1.98448895
87Progressive neurologic deterioration (HP:0002344)1.98134421
88Chronic otitis media (HP:0000389)1.97531225
89Increased CSF protein (HP:0002922)1.97148364
90Lymphopenia (HP:0001888)1.96328192
91Restrictive lung disease (HP:0002091)1.95438563
92Myocardial infarction (HP:0001658)1.93215631
93Abnormality of the nasal mucosa (HP:0000433)1.92164105
94Acne (HP:0001061)1.90663245
95Premature loss of primary teeth (HP:0006323)1.90226854
96Basal ganglia calcification (HP:0002135)1.87753392
97Inappropriate behavior (HP:0000719)1.86063012
98Glomerulopathy (HP:0100820)1.86039265
99Nasal polyposis (HP:0100582)1.85479666
100Global brain atrophy (HP:0002283)1.85369463

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.36396804
2BLK3.72334496
3MAP4K13.42003003
4TYK23.31239591
5CSK2.71556975
6MAP3K142.48570652
7PRPF4B2.43168992
8IRAK42.39022703
9FES2.33552323
10TXK2.28604350
11MAP2K32.23267363
12FGR2.11319727
13ZAP702.06541150
14ERN12.04701797
15GRK71.93843310
16JAK31.92175829
17TBK11.85971588
18IKBKE1.84167213
19MAP3K131.78771089
20TAOK11.75300095
21SYK1.74012567
22MATK1.72461035
23MAP3K31.71892324
24TNK21.71226007
25JAK11.62682046
26BTK1.62182759
27CSF1R1.57873667
28TGFBR21.51700416
29MAP3K111.48142355
30LYN1.45524708
31HCK1.43763601
32IKBKB1.43018527
33IRAK31.41056191
34TAOK31.39130584
35JAK21.30759809
36KIT1.30284578
37GRK61.28784336
38LCK1.25993415
39ITK1.22920884
40EPHB11.20325836
41MAP3K11.14819979
42TAOK21.13663037
43CDC42BPA1.13461501
44BMPR21.06021674
45SIK31.03776406
46TEC1.01719575
47MARK31.00851196
48STK100.95746608
49IRAK10.89039675
50YES10.87955576
51PDK10.86307036
52ACVR1B0.86073769
53MAPK70.81018343
54CAMKK20.76915540
55IRAK20.75750912
56MARK20.74729403
57MOS0.72603129
58FGFR30.71651243
59PDPK10.70774991
60ADRBK20.64044540
61NLK0.63698436
62RIPK10.63402264
63PRKCQ0.62416788
64FGFR40.60411234
65FYN0.60080173
66DAPK20.58756376
67HIPK20.58080001
68TESK20.57669329
69MAPK120.56628241
70EPHA30.56371977
71MAP3K50.56182384
72KSR20.54931707
73CHUK0.53019888
74PRKD20.51083951
75RPS6KL10.50289531
76RPS6KC10.50289531
77CDK60.49134148
78SGK30.48366771
79DDR20.48140339
80MAP2K60.48003830
81SIK20.45523208
82CAMK1D0.45417617
83DYRK1B0.44397536
84PIM10.44172862
85RPS6KA60.42880209
86STK110.40004107
87ABL10.39211923
88SGK20.38609155
89CAMKK10.38222783
90CDK190.36054032
91RPS6KA20.34069433
92PIK3CG0.33720285
93LRRK20.32196440
94MAP3K70.31624131
95PTK60.31286797
96MAPK40.29378429
97EGFR0.29184286
98MAP3K60.26378352
99MAP3K20.26360593
100PDGFRB0.24892986

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.21695001
2Leishmaniasis_Homo sapiens_hsa051402.96762093
3Allograft rejection_Homo sapiens_hsa053302.90756600
4Osteoclast differentiation_Homo sapiens_hsa043802.87482138
5Graft-versus-host disease_Homo sapiens_hsa053322.78747917
6Other glycan degradation_Homo sapiens_hsa005112.64005713
7Autoimmune thyroid disease_Homo sapiens_hsa053202.60601855
8Asthma_Homo sapiens_hsa053102.47941555
9Type I diabetes mellitus_Homo sapiens_hsa049402.27000391
10Tuberculosis_Homo sapiens_hsa051522.22792257
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22193591
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.19272927
13Intestinal immune network for IgA production_Homo sapiens_hsa046722.17002191
14Lysosome_Homo sapiens_hsa041422.11224720
15Rheumatoid arthritis_Homo sapiens_hsa053232.02670624
16Antigen processing and presentation_Homo sapiens_hsa046121.99250546
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86966913
18B cell receptor signaling pathway_Homo sapiens_hsa046621.81281840
19Malaria_Homo sapiens_hsa051441.81249115
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.80765712
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.78975923
22Hematopoietic cell lineage_Homo sapiens_hsa046401.76706316
23Primary immunodeficiency_Homo sapiens_hsa053401.75128632
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68120898
25Viral myocarditis_Homo sapiens_hsa054161.60746000
26Phagosome_Homo sapiens_hsa041451.60220159
27Legionellosis_Homo sapiens_hsa051341.59604176
28Pertussis_Homo sapiens_hsa051331.58409902
29Toxoplasmosis_Homo sapiens_hsa051451.56107517
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.53955716
31Influenza A_Homo sapiens_hsa051641.49154022
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.48703659
33Chemokine signaling pathway_Homo sapiens_hsa040621.46679715
34Measles_Homo sapiens_hsa051621.40160551
35T cell receptor signaling pathway_Homo sapiens_hsa046601.38728576
36TNF signaling pathway_Homo sapiens_hsa046681.37810913
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37159681
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35673284
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.25340286
40Herpes simplex infection_Homo sapiens_hsa051681.24524851
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.15808537
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.15621053
43Salmonella infection_Homo sapiens_hsa051321.14622407
44Acute myeloid leukemia_Homo sapiens_hsa052211.14399412
45African trypanosomiasis_Homo sapiens_hsa051431.12592425
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00525925
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97611158
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94996585
49Hepatitis C_Homo sapiens_hsa051600.92867450
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91216078
51Hepatitis B_Homo sapiens_hsa051610.87632505
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.84682071
53Collecting duct acid secretion_Homo sapiens_hsa049660.84459159
54Platelet activation_Homo sapiens_hsa046110.78411299
55Shigellosis_Homo sapiens_hsa051310.75537869
56Apoptosis_Homo sapiens_hsa042100.73364739
57Prolactin signaling pathway_Homo sapiens_hsa049170.65972267
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62871530
59Sphingolipid signaling pathway_Homo sapiens_hsa040710.62469648
60Amoebiasis_Homo sapiens_hsa051460.61792944
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61600858
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60287359
63Type II diabetes mellitus_Homo sapiens_hsa049300.56127097
64Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56028116
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.55775695
66Epstein-Barr virus infection_Homo sapiens_hsa051690.55762058
67Dorso-ventral axis formation_Homo sapiens_hsa043200.55260678
68VEGF signaling pathway_Homo sapiens_hsa043700.55162270
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.54961686
70Complement and coagulation cascades_Homo sapiens_hsa046100.52271792
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51948649
72Notch signaling pathway_Homo sapiens_hsa043300.47217256
73Non-small cell lung cancer_Homo sapiens_hsa052230.46212629
74Endocytosis_Homo sapiens_hsa041440.45912464
75Renal cell carcinoma_Homo sapiens_hsa052110.44678492
76Pancreatic cancer_Homo sapiens_hsa052120.41895604
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.41518734
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39179073
79GnRH signaling pathway_Homo sapiens_hsa049120.38671652
80Chronic myeloid leukemia_Homo sapiens_hsa052200.37627924
81Prion diseases_Homo sapiens_hsa050200.37621519
82HTLV-I infection_Homo sapiens_hsa051660.36954282
83FoxO signaling pathway_Homo sapiens_hsa040680.36506886
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35916479
85Sphingolipid metabolism_Homo sapiens_hsa006000.34997638
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34752779
87HIF-1 signaling pathway_Homo sapiens_hsa040660.34426630
88Insulin resistance_Homo sapiens_hsa049310.33020360
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.31425043
90mTOR signaling pathway_Homo sapiens_hsa041500.26571712
91MAPK signaling pathway_Homo sapiens_hsa040100.25680132
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.24710220
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24102797
94Viral carcinogenesis_Homo sapiens_hsa052030.23602860
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.23531094
96Choline metabolism in cancer_Homo sapiens_hsa052310.22781933
97Regulation of autophagy_Homo sapiens_hsa041400.21970796
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.19525696
99Rap1 signaling pathway_Homo sapiens_hsa040150.18684691
100Endometrial cancer_Homo sapiens_hsa052130.17103794

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