CEBPG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.86447668
2nuclear pore organization (GO:0006999)5.29572359
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.80920222
4L-phenylalanine catabolic process (GO:0006559)4.80920222
5Golgi transport vesicle coating (GO:0048200)4.68827550
6COPI coating of Golgi vesicle (GO:0048205)4.68827550
7regulation of translational fidelity (GO:0006450)4.58691066
8DNA unwinding involved in DNA replication (GO:0006268)4.47097731
9L-serine metabolic process (GO:0006563)4.43667132
10peptidyl-glutamic acid carboxylation (GO:0017187)4.39177740
11protein carboxylation (GO:0018214)4.39177740
12triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.39068221
13erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.36967210
14L-phenylalanine metabolic process (GO:0006558)4.36967210
15urea cycle (GO:0000050)4.31254521
16urea metabolic process (GO:0019627)4.31254521
17mitotic sister chromatid cohesion (GO:0007064)4.29087211
18alpha-linolenic acid metabolic process (GO:0036109)4.26675881
19pore complex assembly (GO:0046931)4.26269207
20sulfur amino acid catabolic process (GO:0000098)4.25201759
21mitotic chromosome condensation (GO:0007076)4.24851899
22complement activation, alternative pathway (GO:0006957)4.21089827
23aromatic amino acid family catabolic process (GO:0009074)4.17379543
24positive regulation of fatty acid beta-oxidation (GO:0032000)4.15283610
25regulation of RNA export from nucleus (GO:0046831)4.13054409
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.07282619
27regulation of triglyceride catabolic process (GO:0010896)3.96550949
28dosage compensation (GO:0007549)3.94542542
29cysteine metabolic process (GO:0006534)3.87146060
30histone H2B ubiquitination (GO:0033523)3.86146982
31serine family amino acid biosynthetic process (GO:0009070)3.84724964
32regulation of chromatin binding (GO:0035561)3.83128984
33formation of translation preinitiation complex (GO:0001731)3.83091131
34nitrogen cycle metabolic process (GO:0071941)3.83063651
35acylglycerol homeostasis (GO:0055090)3.81935258
36triglyceride homeostasis (GO:0070328)3.81935258
37negative regulation of fibrinolysis (GO:0051918)3.80534175
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78830629
39regulation of protein activation cascade (GO:2000257)3.77264289
40regulation of sequestering of triglyceride (GO:0010889)3.69813062
41high-density lipoprotein particle remodeling (GO:0034375)3.69404160
42phospholipid efflux (GO:0033700)3.67700646
43negative regulation of lipase activity (GO:0060192)3.63561496
44regulation of fibrinolysis (GO:0051917)3.58933125
45regulation of complement activation (GO:0030449)3.57194182
46tRNA aminoacylation for protein translation (GO:0006418)3.56408908
47phospholipid homeostasis (GO:0055091)3.56141808
48tryptophan metabolic process (GO:0006568)3.56023420
49positive regulation of lipid catabolic process (GO:0050996)3.55128626
50DNA topological change (GO:0006265)3.55120581
51maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54316173
52brown fat cell differentiation (GO:0050873)3.50201155
53indole-containing compound catabolic process (GO:0042436)3.49597640
54indolalkylamine catabolic process (GO:0046218)3.49597640
55tryptophan catabolic process (GO:0006569)3.49597640
56mRNA stabilization (GO:0048255)3.49025707
57RNA stabilization (GO:0043489)3.49025707
58tRNA aminoacylation (GO:0043039)3.45659271
59amino acid activation (GO:0043038)3.45659271
60reverse cholesterol transport (GO:0043691)3.45493760
61cellular glucuronidation (GO:0052695)3.45071091
62homocysteine metabolic process (GO:0050667)3.44262470
63regulation of nucleobase-containing compound transport (GO:0032239)3.42873863
64amino-acid betaine metabolic process (GO:0006577)3.42752049
65sister chromatid segregation (GO:0000819)3.40597114
66plasma lipoprotein particle clearance (GO:0034381)3.40506270
67positive regulation of fatty acid oxidation (GO:0046321)3.40196385
68cellular protein complex localization (GO:0034629)3.38412063
69retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.38110023
70NADH metabolic process (GO:0006734)3.36264858
71protein localization to chromosome, centromeric region (GO:0071459)3.34905246
72ribosome assembly (GO:0042255)3.32297308
73low-density lipoprotein particle clearance (GO:0034383)3.31634223
74mitotic sister chromatid segregation (GO:0000070)3.30726293
75bile acid biosynthetic process (GO:0006699)3.29902448
76negative regulation of fatty acid biosynthetic process (GO:0045717)3.25729360
77ER overload response (GO:0006983)3.24263435
78bile acid and bile salt transport (GO:0015721)3.23944057
79proline biosynthetic process (GO:0006561)3.23929056
80regulation of fatty acid beta-oxidation (GO:0031998)3.20744416
81negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.19239755
82kynurenine metabolic process (GO:0070189)3.17564051
83growth hormone receptor signaling pathway (GO:0060396)3.17465985
84bile acid metabolic process (GO:0008206)3.17223885
85plasma lipoprotein particle assembly (GO:0034377)3.16876493
86cholesterol efflux (GO:0033344)3.15933834
87plasma lipoprotein particle remodeling (GO:0034369)3.15480718
88protein-lipid complex remodeling (GO:0034368)3.15480718
89macromolecular complex remodeling (GO:0034367)3.15480718
90negative regulation of mRNA processing (GO:0050686)3.15368517
91intestinal cholesterol absorption (GO:0030299)3.15171858
92regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14234909
93fatty acid oxidation (GO:0019395)3.12644196
94regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11179776
95tyrosine metabolic process (GO:0006570)3.09284890
96COPII vesicle coating (GO:0048208)3.08937876
97regulation of mitotic spindle organization (GO:0060236)3.08246567
98positive regulation of glycolytic process (GO:0045821)3.05028793
99regulation of translational elongation (GO:0006448)3.04597840
100fibrinolysis (GO:0042730)3.03948591
101protein retention in ER lumen (GO:0006621)3.03148887
102lipid oxidation (GO:0034440)3.03016906
103protein-lipid complex assembly (GO:0065005)3.01291904
104fatty acid beta-oxidation (GO:0006635)2.98941699
105protein complex localization (GO:0031503)2.98774916
106spliceosomal tri-snRNP complex assembly (GO:0000244)2.98589247
107fatty acid transmembrane transport (GO:1902001)2.97978952
108DNA strand elongation involved in DNA replication (GO:0006271)2.97814394
109carnitine metabolic process (GO:0009437)2.97318867
110regulation of cholesterol storage (GO:0010885)2.94993802
111negative regulation of transcription regulatory region DNA binding (GO:2000678)2.92857338
112regulation of NFAT protein import into nucleus (GO:0051532)2.92045059
113aromatic amino acid family metabolic process (GO:0009072)2.91956186
114positive regulation of cholesterol transport (GO:0032376)2.91318142
115positive regulation of sterol transport (GO:0032373)2.91318142
116positive regulation of chromosome segregation (GO:0051984)2.90779453
117valine metabolic process (GO:0006573)2.90727437
118drug catabolic process (GO:0042737)2.90665151
119transcytosis (GO:0045056)2.90249220
120regulation of cholesterol esterification (GO:0010872)2.87012074
121cholesterol homeostasis (GO:0042632)2.86257186
122sterol homeostasis (GO:0055092)2.86034059
123DNA strand elongation (GO:0022616)2.86019946
124biotin metabolic process (GO:0006768)2.85787405
125uronic acid metabolic process (GO:0006063)2.85555485
126glucuronate metabolic process (GO:0019585)2.85555485
127positive regulation of nuclease activity (GO:0032075)2.84611381
128negative regulation of sterol transport (GO:0032372)2.84527278
129negative regulation of cholesterol transport (GO:0032375)2.84527278
130flavonoid metabolic process (GO:0009812)2.83343295
131negative regulation of glycogen biosynthetic process (GO:0045719)2.82953167
132negative regulation of mRNA metabolic process (GO:1903312)2.82780664
133activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.82206416
134regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.82193839
135negative regulation of RNA splicing (GO:0033119)2.81967693
136serine family amino acid catabolic process (GO:0009071)2.80682473
137DNA ligation (GO:0006266)2.80476097
138non-recombinational repair (GO:0000726)2.80222022
139double-strand break repair via nonhomologous end joining (GO:0006303)2.80222022
140intestinal absorption (GO:0050892)2.80180836
141positive regulation of cholesterol efflux (GO:0010875)2.79814525
142regulation of sister chromatid cohesion (GO:0007063)2.79496454
143positive regulation of triglyceride metabolic process (GO:0090208)2.78413426
144hormone catabolic process (GO:0042447)2.76987647
145regulation of bile acid biosynthetic process (GO:0070857)2.76938707
146ethanol oxidation (GO:0006069)2.76603845
147complement activation (GO:0006956)2.76515619
148plasma lipoprotein particle organization (GO:0071827)2.76330204
149lysine catabolic process (GO:0006554)2.75293987
150lysine metabolic process (GO:0006553)2.75293987
151regulation of DNA damage checkpoint (GO:2000001)2.75190303
152regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 2.73882334
153positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling2.73882334
154positive regulation of cell cycle checkpoint (GO:1901978)2.73180925
155xenobiotic catabolic process (GO:0042178)2.73012597
156vesicle coating (GO:0006901)2.71728434
157intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.71301225
158very-low-density lipoprotein particle assembly (GO:0034379)2.71001958
159lipoprotein metabolic process (GO:0042157)2.70839024
160renal system development (GO:0072001)2.70684206
161ER-nucleus signaling pathway (GO:0006984)2.70289240
162protein-lipid complex subunit organization (GO:0071825)2.69896977
163positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.68321500
164protein localization to kinetochore (GO:0034501)2.68270825
165endoplasmic reticulum unfolded protein response (GO:0030968)2.67216295
166nuclear envelope disassembly (GO:0051081)2.66542325
167membrane disassembly (GO:0030397)2.66542325
168protein export from nucleus (GO:0006611)2.64968980
169regulation of mRNA stability (GO:0043488)2.64951659
170mitotic nuclear envelope disassembly (GO:0007077)2.64674338
171mitotic metaphase plate congression (GO:0007080)2.60949281
172mitochondrial DNA metabolic process (GO:0032042)2.60213378
173establishment of integrated proviral latency (GO:0075713)2.59112448
174protein localization to chromosome (GO:0034502)2.58422174
175regulation of translational initiation (GO:0006446)2.56444283
176nucleobase-containing small molecule interconversion (GO:0015949)2.54731594
177glutamine metabolic process (GO:0006541)2.54184668
178gluconeogenesis (GO:0006094)2.53732525
179regulation of DNA endoreduplication (GO:0032875)2.53414700
180regulation of nuclease activity (GO:0032069)2.53021496
181DNA replication checkpoint (GO:0000076)2.52780849
182regulation of spindle organization (GO:0090224)2.51472933
183mRNA transport (GO:0051028)2.51020238
184proline metabolic process (GO:0006560)2.50778479
185cytoplasmic mRNA processing body assembly (GO:0033962)2.50768799
186cellular response to unfolded protein (GO:0034620)2.50154130
187stress granule assembly (GO:0034063)2.49545622
188DNA replication initiation (GO:0006270)2.49409515
189embryonic process involved in female pregnancy (GO:0060136)2.47279008
190viral mRNA export from host cell nucleus (GO:0046784)2.46308983
191regulation of RNA stability (GO:0043487)2.45431078
192folic acid-containing compound biosynthetic process (GO:0009396)2.45001237
193RNA export from nucleus (GO:0006405)2.44784525
194positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.44654833
195positive regulation of mitotic sister chromatid separation (GO:1901970)2.44654833

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.92222955
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.28481935
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.91592159
4LXR_22158963_ChIP-Seq_LIVER_Mouse4.52586476
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.32320832
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.17950190
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.88876769
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.81610949
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.74967918
10* MYC_18555785_ChIP-Seq_MESCs_Mouse3.71375664
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16096105
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.08347896
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.04995176
14AR_21909140_ChIP-Seq_LNCAP_Human3.04707003
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.86351822
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.85264503
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.82711941
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.74004523
19STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.73964552
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71804555
21GATA1_22025678_ChIP-Seq_K562_Human2.69670231
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.56858802
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.50389812
24* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.48691640
25* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.48397212
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.48193623
27BP1_19119308_ChIP-ChIP_Hs578T_Human2.44606705
28MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39097216
29TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38807407
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36095367
31TP63_17297297_ChIP-ChIP_HaCaT_Human2.35598784
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.35205523
33CLOCK_20551151_ChIP-Seq_293T_Human2.29596334
34MYCN_18555785_ChIP-Seq_MESCs_Mouse2.26631106
35XRN2_22483619_ChIP-Seq_HELA_Human2.22950363
36THAP11_20581084_ChIP-Seq_MESCs_Mouse2.19523463
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.16520758
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.15607489
39MYC_18358816_ChIP-ChIP_MESCs_Mouse2.12890129
40DCP1A_22483619_ChIP-Seq_HELA_Human2.12379953
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.11238087
42* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.00100920
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.99816345
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.99418097
45RBPJ_22232070_ChIP-Seq_NCS_Mouse1.98375886
46TTF2_22483619_ChIP-Seq_HELA_Human1.82234743
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.76202060
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75724865
49STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74513451
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.70834042
51* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.70218140
52* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.70154026
53CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.69731387
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68719058
55KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68121335
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67344287
57CHD1_26751641_Chip-Seq_LNCaP_Human1.65709698
58* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65622864
59CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.62232878
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62020302
61FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.59969387
62ETS1_20019798_ChIP-Seq_JURKAT_Human1.58656533
63E2F1_18555785_ChIP-Seq_MESCs_Mouse1.57950947
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.57777006
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57007264
66GABP_19822575_ChIP-Seq_HepG2_Human1.56208556
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54418731
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.46345284
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.45477132
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44745629
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.44707609
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44385725
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.42668721
74NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41309240
75TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.41243274
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.40704403
77SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39772670
78NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38970701
79POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37834321
80ZNF263_19887448_ChIP-Seq_K562_Human1.37467933
81JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.36669835
82* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35872273
83MYC_22102868_ChIP-Seq_BL_Human1.35337697
84E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.34950598
85NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34790500
86SOX9_24532713_ChIP-Seq_HFSC_Mouse1.33452090
87KDM5A_27292631_Chip-Seq_BREAST_Human1.32978034
88AHR_22903824_ChIP-Seq_MCF-7_Human1.32612668
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30862558
90CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30242541
91SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29040241
92* ATF3_27146783_Chip-Seq_COLON_Human1.28950220
93* GATA4_25053715_ChIP-Seq_YYC3_Human1.27786057
94CDX2_22108803_ChIP-Seq_LS180_Human1.27579608
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.27535625
96SMAD_19615063_ChIP-ChIP_OVARY_Human1.26845218
97NANOG_21062744_ChIP-ChIP_HESCs_Human1.25240136
98SOX2_20726797_ChIP-Seq_SW620_Human1.24352305
99ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23208771
100* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22074030
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21312479
102TFEB_21752829_ChIP-Seq_HELA_Human1.20921350
103FOXA1_25552417_ChIP-Seq_VCAP_Human1.19887485
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18689161
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.18253480
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18088354
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17392581
108AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17220628
109EGR1_19374776_ChIP-ChIP_THP-1_Human1.16294999
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.16260547
111* CJUN_26792858_Chip-Seq_BT549_Human1.15762891
112NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15417843
113PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13978656
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13463581
115* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.12517892
116VDR_24787735_ChIP-Seq_THP-1_Human1.11991844
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11681630
118GATA6_25053715_ChIP-Seq_YYC3_Human1.10794659
119* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10670339
120* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.10405911
121TAF15_26573619_Chip-Seq_HEK293_Human1.10283506
122MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10240341
123BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.10013840
124FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09743564
125* IRF8_27001747_Chip-Seq_BMDM_Mouse1.09044092
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07608091
127TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.06489747
128ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05337140
129SALL4_18804426_ChIP-ChIP_XEN_Mouse1.04548571
130HNF4A_19822575_ChIP-Seq_HepG2_Human1.03581718
131* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.03147659
132NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02213509
133NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02052013
134HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01805513
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.00417071
136STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00337498
137SOX17_20123909_ChIP-Seq_XEN_Mouse1.00066043
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.99590059
139TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99462972
140GATA2_21666600_ChIP-Seq_HMVEC_Human0.98537831
141STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98439197
142BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98139470
143HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97986577
144P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96938157
145CIITA_25753668_ChIP-Seq_RAJI_Human0.96009865
146TP53_18474530_ChIP-ChIP_U2OS_Human0.95092570
147EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.94203968
148BCAT_22108803_ChIP-Seq_LS180_Human0.94144354
149PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93654860
150FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.93303122
151RXR_22108803_ChIP-Seq_LS180_Human0.93283812
152E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.92793019
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92391381
154ARNT_22903824_ChIP-Seq_MCF-7_Human0.92268455
155FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91635834
156WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.91524438
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91314674
158CDX2_20551321_ChIP-Seq_CACO-2_Human0.90937072
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90902186
160ELK1_19687146_ChIP-ChIP_HELA_Human0.90830635
161HIF1A_21447827_ChIP-Seq_MCF-7_Human0.89447039
162CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89431787
163SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88255815
164* TP63_23658742_ChIP-Seq_EP156T_Human0.87987359
165ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87972584
166* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.87912482
167GABP_17652178_ChIP-ChIP_JURKAT_Human0.87657106
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.87437909
169* RUNX1_27514584_Chip-Seq_MCF-7_Human0.86514888
170ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85799040
171GATA2_19941826_ChIP-Seq_K562_Human0.83734079
172PIAS1_25552417_ChIP-Seq_VCAP_Human0.82203885
173NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81930873
174NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81930873
175ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80919674
176PKCTHETA_26484144_Chip-Seq_BREAST_Human0.80521580
177BRD4_25478319_ChIP-Seq_HGPS_Human0.79460872
178TBX20_22328084_ChIP-Seq_HEART_Mouse0.78385988
179TBX20_22080862_ChIP-Seq_HEART_Mouse0.78385988
180GATA1_19941826_ChIP-Seq_K562_Human0.78114632

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.19275617
2MP0005360_urolithiasis5.03445092
3MP0005365_abnormal_bile_salt4.34479538
4MP0003693_abnormal_embryo_hatching3.76515584
5MP0005085_abnormal_gallbladder_physiolo3.75598926
6MP0008875_abnormal_xenobiotic_pharmacok3.14602878
7MP0003252_abnormal_bile_duct3.13421953
8MP0004957_abnormal_blastocyst_morpholog3.11784582
9MP0003111_abnormal_nucleus_morphology2.92141870
10MP0010234_abnormal_vibrissa_follicle2.92053711
11MP0008789_abnormal_olfactory_epithelium2.91622925
12MP0010329_abnormal_lipoprotein_level2.68844031
13MP0010094_abnormal_chromosome_stability2.53026713
14MP0002138_abnormal_hepatobiliary_system2.38528337
15MP0010352_gastrointestinal_tract_polyps2.37785917
16MP0003077_abnormal_cell_cycle2.37779359
17MP0003300_gastrointestinal_ulcer2.35800281
18MP0008057_abnormal_DNA_replication2.30592295
19MP0001666_abnormal_nutrient_absorption2.26953749
20MP0003221_abnormal_cardiomyocyte_apopto2.20162687
21MP0004233_abnormal_muscle_weight2.18877533
22MP0001730_embryonic_growth_arrest2.15718234
23MP0003705_abnormal_hypodermis_morpholog2.13734234
24MP0008932_abnormal_embryonic_tissue2.13168103
25MP0005451_abnormal_body_composition2.04770561
26MP0005394_taste/olfaction_phenotype2.03647097
27MP0005499_abnormal_olfactory_system2.03647097
28MP0000537_abnormal_urethra_morphology1.97961275
29MP0000350_abnormal_cell_proliferation1.84026543
30MP0001188_hyperpigmentation1.81277940
31MP0009840_abnormal_foam_cell1.80350811
32MP0000747_muscle_weakness1.77565987
33MP0003191_abnormal_cellular_cholesterol1.77183800
34MP0003890_abnormal_embryonic-extraembry1.75393111
35MP0000609_abnormal_liver_physiology1.69368496
36MP0003195_calcinosis1.68518986
37MP0004185_abnormal_adipocyte_glucose1.62085303
38MP0003123_paternal_imprinting1.59051507
39MP0001727_abnormal_embryo_implantation1.56565427
40MP0002118_abnormal_lipid_homeostasis1.56264157
41MP0004197_abnormal_fetal_growth/weight/1.53567095
42MP0003806_abnormal_nucleotide_metabolis1.52285517
43MP0001672_abnormal_embryogenesis/_devel1.50281116
44MP0005380_embryogenesis_phenotype1.50281116
45MP0001697_abnormal_embryo_size1.47744393
46MP0003868_abnormal_feces_composition1.46831003
47MP0005501_abnormal_skin_physiology1.42983574
48MP0005187_abnormal_penis_morphology1.42388865
49MP0002084_abnormal_developmental_patter1.42279100
50MP0003984_embryonic_growth_retardation1.39020423
51MP0002080_prenatal_lethality1.38636252
52MP0003315_abnormal_perineum_morphology1.38633188
53MP0000427_abnormal_hair_cycle1.38474207
54MP0008007_abnormal_cellular_replicative1.38237165
55MP0002877_abnormal_melanocyte_morpholog1.36327930
56MP0002971_abnormal_brown_adipose1.35138796
57MP0002896_abnormal_bone_mineralization1.34126533
58MP0004130_abnormal_muscle_cell1.32701678
59MP0005666_abnormal_adipose_tissue1.32298569
60MP0002088_abnormal_embryonic_growth/wei1.30798375
61MP0005332_abnormal_amino_acid1.29975676
62MP0000490_abnormal_crypts_of1.29624511
63MP0008058_abnormal_DNA_repair1.29372477
64MP0003724_increased_susceptibility_to1.25516409
65MP0002086_abnormal_extraembryonic_tissu1.25424383
66MP0003453_abnormal_keratinocyte_physiol1.24836560
67MP0002254_reproductive_system_inflammat1.24204045
68MP0005670_abnormal_white_adipose1.24151101
69MP0000647_abnormal_sebaceous_gland1.22525925
70MP0004147_increased_porphyrin_level1.21814231
71MP0002085_abnormal_embryonic_tissue1.21769964
72MP0002697_abnormal_eye_size1.18062866
73MP0000003_abnormal_adipose_tissue1.17959716
74MP0005375_adipose_tissue_phenotype1.17790359
75MP0010307_abnormal_tumor_latency1.14574591
76MP0005220_abnormal_exocrine_pancreas1.13445460
77MP0009053_abnormal_anal_canal1.11825468
78MP0001984_abnormal_olfaction1.11288423
79MP0002822_catalepsy1.09674166
80MP0009643_abnormal_urine_homeostasis1.09468580
81MP0005645_abnormal_hypothalamus_physiol1.09408246
82MP0000313_abnormal_cell_death1.09170325
83MP0002060_abnormal_skin_morphology1.09125342
84MP0005319_abnormal_enzyme/_coenzyme1.08660744
85MP0002269_muscular_atrophy1.07433880
86MP0004270_analgesia1.05462724
87MP0009115_abnormal_fat_cell1.04549441
88MP0003941_abnormal_skin_development1.04537714
89MP0002928_abnormal_bile_duct1.03925771
90MP0001542_abnormal_bone_strength1.03604060
91MP0010678_abnormal_skin_adnexa1.02582246
92MP0001661_extended_life_span1.02102452
93MP0004087_abnormal_muscle_fiber1.00119499
94MP0004019_abnormal_vitamin_homeostasis0.99962110
95MP0008260_abnormal_autophagy0.98983346
96MP0005275_abnormal_skin_tensile0.98278998
97MP0000377_abnormal_hair_follicle0.97826222
98MP0002166_altered_tumor_susceptibility0.97208079
99MP0002009_preneoplasia0.96873336
100MP0003656_abnormal_erythrocyte_physiolo0.96662776
101MP0009379_abnormal_foot_pigmentation0.95955692
102MP0003937_abnormal_limbs/digits/tail_de0.94855576
103MP0004264_abnormal_extraembryonic_tissu0.92196495
104MP0002796_impaired_skin_barrier0.91225365
105MP0006054_spinal_hemorrhage0.91192133
106MP0005384_cellular_phenotype0.91167526
107MP0005334_abnormal_fat_pad0.91100553
108MP0005248_abnormal_Harderian_gland0.89875983
109MP0000678_abnormal_parathyroid_gland0.89145622
110MP0005621_abnormal_cell_physiology0.87270581
111MP0002233_abnormal_nose_morphology0.87207869
112MP0005083_abnormal_biliary_tract0.86968179
113MP0004782_abnormal_surfactant_physiolog0.86629324
114MP0005408_hypopigmentation0.86591030
115MP0008438_abnormal_cutaneous_collagen0.86338378
116MP0002098_abnormal_vibrissa_morphology0.85790157
117MP0009703_decreased_birth_body0.85695843
118MP0000759_abnormal_skeletal_muscle0.84947431
119MP0001286_abnormal_eye_development0.84180347
120MP0003567_abnormal_fetal_cardiomyocyte0.83416399
121MP0009697_abnormal_copulation0.82973889
122MP0000598_abnormal_liver_morphology0.82945873
123MP0005647_abnormal_sex_gland0.82682676
124MP0002168_other_aberrant_phenotype0.82600247
125MP0005409_darkened_coat_color0.82083622
126MP0005367_renal/urinary_system_phenotyp0.81952457
127MP0000516_abnormal_urinary_system0.81952457
128MP0003861_abnormal_nervous_system0.81247768
129MP0001881_abnormal_mammary_gland0.80209458
130MP0003385_abnormal_body_wall0.79790335
131MP0001293_anophthalmia0.79771690
132MP0003121_genomic_imprinting0.79384962
133MP0010630_abnormal_cardiac_muscle0.79132567
134MP0001216_abnormal_epidermal_layer0.79038104
135MP0009672_abnormal_birth_weight0.78811081
136MP0005076_abnormal_cell_differentiation0.78689709
137MP0000358_abnormal_cell_content/0.77583812
138MP0000778_abnormal_nervous_system0.77074838
139MP0000462_abnormal_digestive_system0.76879022
140MP0009763_increased_sensitivity_to0.76297177
141MP0001944_abnormal_pancreas_morphology0.74645574
142MP0000762_abnormal_tongue_morphology0.74221977
143MP0002078_abnormal_glucose_homeostasis0.74174073
144MP0010368_abnormal_lymphatic_system0.73788849
145MP0000579_abnormal_nail_morphology0.73236827
146MP0001529_abnormal_vocalization0.72518502
147MP0004272_abnormal_basement_membrane0.70987486
148MP0003436_decreased_susceptibility_to0.69542192
149MP0000477_abnormal_intestine_morphology0.69133117
150MP0004811_abnormal_neuron_physiology0.69113822
151MP0005584_abnormal_enzyme/coenzyme_acti0.68622076
152MP0008004_abnormal_stomach_pH0.68299118
153MP0000372_irregular_coat_pigmentation0.67893803
154MP0005623_abnormal_meninges_morphology0.66782181
155MP0002115_abnormal_skeleton_extremities0.65512043
156MP0004134_abnormal_chest_morphology0.64758298
157MP0001756_abnormal_urination0.63597804
158MP0003566_abnormal_cell_adhesion0.62317515
159MP0009764_decreased_sensitivity_to0.61957756
160MP0009250_abnormal_appendicular_skeleto0.60655799
161MP0002092_abnormal_eye_morphology0.59366578
162MP0008469_abnormal_protein_level0.59135237
163MP0000566_synostosis0.58644301
164MP0003795_abnormal_bone_structure0.57894557
165MP0002970_abnormal_white_adipose0.57222591
166MP0000627_abnormal_mammary_gland0.56396854
167MP0000383_abnormal_hair_follicle0.56358271

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.18990244
2Cortical dysplasia (HP:0002539)5.03353062
3Complement deficiency (HP:0004431)4.43714089
4Prolonged partial thromboplastin time (HP:0003645)4.30250905
5Xanthomatosis (HP:0000991)4.27146685
6Abnormality of monocarboxylic acid metabolism (HP:0010996)4.15508607
7Intrahepatic cholestasis (HP:0001406)4.13504491
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.99290961
9Hyperlipoproteinemia (HP:0010980)3.98660935
10Myocardial infarction (HP:0001658)3.97141448
11Joint hemorrhage (HP:0005261)3.87763243
12Hypoalphalipoproteinemia (HP:0003233)3.76844474
13Abnormality of the common coagulation pathway (HP:0010990)3.58079918
14Calcaneovalgus deformity (HP:0001848)3.43391924
15Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.42699459
16Epidermoid cyst (HP:0200040)3.39625256
17Abnormality of complement system (HP:0005339)3.36822608
18Multiple enchondromatosis (HP:0005701)3.28850217
19Hypolipoproteinemia (HP:0010981)3.26059977
20Hypobetalipoproteinemia (HP:0003563)3.06496915
21Vertebral arch anomaly (HP:0008438)3.04546569
22Ketosis (HP:0001946)3.04101964
23Hyperglycinuria (HP:0003108)2.95999661
24Hemorrhage of the eye (HP:0011885)2.93809396
25Upper limb muscle weakness (HP:0003484)2.90678024
26Abnormality of the calcaneus (HP:0008364)2.90582476
27Esophageal varix (HP:0002040)2.87988979
28Deformed tarsal bones (HP:0008119)2.83280845
29Exercise-induced myalgia (HP:0003738)2.83070347
30Papillary thyroid carcinoma (HP:0002895)2.81964416
31Hammertoe (HP:0001765)2.81743313
32Hypoglycemic coma (HP:0001325)2.80824804
33Abnormality of the intrinsic pathway (HP:0010989)2.78382145
34Hyperglycinemia (HP:0002154)2.77806847
35Conjugated hyperbilirubinemia (HP:0002908)2.73891797
36Abnormality of serine family amino acid metabolism (HP:0010894)2.70488241
37Abnormality of glycine metabolism (HP:0010895)2.70488241
38Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66377792
39Chromosomal breakage induced by crosslinking agents (HP:0003221)2.63900937
40Abnormality of glycolysis (HP:0004366)2.60809283
41Chromsome breakage (HP:0040012)2.59998418
42Hyperammonemia (HP:0001987)2.59684723
43Ketoacidosis (HP:0001993)2.57606662
44Hematochezia (HP:0002573)2.56172738
45Exercise-induced muscle cramps (HP:0003710)2.56039617
46Recurrent gram-negative bacterial infections (HP:0005420)2.54382449
47Breech presentation (HP:0001623)2.54324643
48Abnormality of purine metabolism (HP:0004352)2.52365739
49Abnormality of the left ventricular outflow tract (HP:0011103)2.51382503
50Subaortic stenosis (HP:0001682)2.51382503
51Vascular calcification (HP:0004934)2.51347500
52Abnormality of lateral ventricle (HP:0030047)2.51110673
53Hypercholesterolemia (HP:0003124)2.50814437
54Septate vagina (HP:0001153)2.50087308
55Termporal pattern (HP:0011008)2.48966783
56Insidious onset (HP:0003587)2.48966783
57Muscle fiber inclusion bodies (HP:0100299)2.48411523
58Increased nuchal translucency (HP:0010880)2.47609231
59Nemaline bodies (HP:0003798)2.47521019
60Deviation of the thumb (HP:0009603)2.47216572
61Abnormality of sulfur amino acid metabolism (HP:0004339)2.45857038
62Proximal placement of thumb (HP:0009623)2.45309114
63Long foot (HP:0001833)2.44045891
64Cardiovascular calcification (HP:0011915)2.43007924
65Progressive muscle weakness (HP:0003323)2.42709536
66Hyperglycemia (HP:0003074)2.39312660
67Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.36865999
68Asymmetry of the thorax (HP:0001555)2.36785602
69Fat malabsorption (HP:0002630)2.34943236
70High anterior hairline (HP:0009890)2.33815043
71Insulin-resistant diabetes mellitus (HP:0000831)2.30450126
72Spontaneous abortion (HP:0005268)2.25451356
73Increased serum pyruvate (HP:0003542)2.24822900
74Hand muscle atrophy (HP:0009130)2.23414674
75Missing ribs (HP:0000921)2.22986480
76Back pain (HP:0003418)2.22910458
77Systemic lupus erythematosus (HP:0002725)2.17556025
78Hepatocellular carcinoma (HP:0001402)2.17289425
79Abnormality of nucleobase metabolism (HP:0010932)2.16044163
80Milia (HP:0001056)2.15054416
81Ankyloglossia (HP:0010296)2.12804890
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12030711
83Gingival bleeding (HP:0000225)2.11678251
84Spontaneous hematomas (HP:0007420)2.11466457
85Hypochromic microcytic anemia (HP:0004840)2.09628402
86Large hands (HP:0001176)2.09051218
87Abnormal gallbladder physiology (HP:0012438)2.07940925
88Cholecystitis (HP:0001082)2.07940925
89Progressive external ophthalmoplegia (HP:0000590)2.06600893
90Abnormal cartilage morphology (HP:0002763)2.06285031
91Unilateral renal agenesis (HP:0000122)2.05830254
92Absent eyelashes (HP:0000561)2.05375840
93Long clavicles (HP:0000890)2.04933522
94Anosmia (HP:0000458)2.04361626
9511 pairs of ribs (HP:0000878)2.04062196
96Rimmed vacuoles (HP:0003805)2.02997223
97Amyloidosis (HP:0011034)2.01363595
98Ragged-red muscle fibers (HP:0003200)2.00226952
99Pheochromocytoma (HP:0002666)1.99864257
100Myoglobinuria (HP:0002913)1.99678649
101Overlapping toe (HP:0001845)1.98701702
102Acanthosis nigricans (HP:0000956)1.98686513
103Selective tooth agenesis (HP:0001592)1.98447427
104Abnormality of aspartate family amino acid metabolism (HP:0010899)1.96707464
105Myopathic facies (HP:0002058)1.96158564
106Enlarged kidneys (HP:0000105)1.95747811
107Glomerulonephritis (HP:0000099)1.95168533
108Distal upper limb amyotrophy (HP:0007149)1.93434298
109Upper limb amyotrophy (HP:0009129)1.93434298
110Insomnia (HP:0100785)1.93119113
111Renal cortical cysts (HP:0000803)1.90434566
112Deep philtrum (HP:0002002)1.89555903
113Centrally nucleated skeletal muscle fibers (HP:0003687)1.89409187
114Toxemia of pregnancy (HP:0100603)1.89362788
115Menorrhagia (HP:0000132)1.88974592
116Distal lower limb amyotrophy (HP:0008944)1.87997512
117Acanthocytosis (HP:0001927)1.87858494
118Ankle clonus (HP:0011448)1.86962009
119Hypoglycemic seizures (HP:0002173)1.86671049
120Shoulder girdle muscle weakness (HP:0003547)1.86631258
121Hepatoblastoma (HP:0002884)1.85825136
122Microvesicular hepatic steatosis (HP:0001414)1.84868789
123Peritonitis (HP:0002586)1.84774630
124Neoplasm of the adrenal cortex (HP:0100641)1.84368632
125Tubulointerstitial nephritis (HP:0001970)1.84233891
126Nephritis (HP:0000123)1.83845121
127Pancreatitis (HP:0001733)1.83474772
128Thyroid carcinoma (HP:0002890)1.83470757
129Abnormality of methionine metabolism (HP:0010901)1.83214296
130Rhabdomyolysis (HP:0003201)1.82968760
131Right ventricular cardiomyopathy (HP:0011663)1.82703042
132Abnormality of the gastric mucosa (HP:0004295)1.81166340
133Embryonal neoplasm (HP:0002898)1.79739153
134Poikilocytosis (HP:0004447)1.78976385
135Hyperacusis (HP:0010780)1.77936613
136Cubitus valgus (HP:0002967)1.77627152
137Volvulus (HP:0002580)1.77460682
138Deep palmar crease (HP:0006191)1.76582727
139Abnormality of proline metabolism (HP:0010907)1.76567030
140Hydroxyprolinuria (HP:0003080)1.76567030
141Abnormality of the foot musculature (HP:0001436)1.76559305
142Foot dorsiflexor weakness (HP:0009027)1.76431165
143Insulin resistance (HP:0000855)1.76386606
144Neonatal hypoglycemia (HP:0001998)1.75977102
145Abnormality of the proximal phalanges of the hand (HP:0009834)1.75818947
146Hypothermia (HP:0002045)1.75387415
147Abnormality of the nasal septum (HP:0000419)1.73038897
148Abnormality of nail color (HP:0100643)1.73025952
149Spastic diplegia (HP:0001264)1.71998719
150Proximal tubulopathy (HP:0000114)1.71979640
151Thrombophlebitis (HP:0004418)1.71515162
152Abnormal respiratory motile cilium physiology (HP:0012261)1.71202647
153Pelvic girdle muscle weakness (HP:0003749)1.70470304
154Dysmetric saccades (HP:0000641)1.70171809
155Gout (HP:0001997)1.68454004
156Hypertriglyceridemia (HP:0002155)1.67526432
157Nephroblastoma (Wilms tumor) (HP:0002667)1.65618930
158Microglossia (HP:0000171)1.65618749
159Conjunctival telangiectasia (HP:0000524)1.65433479
160Abnormality of the diencephalon (HP:0010662)1.64767379
161Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.64671267
162Abnormality of fatty-acid metabolism (HP:0004359)1.64210220
163Abnormal tarsal ossification (HP:0008369)1.64158151
164Osteolytic defects of the hand bones (HP:0009699)1.62531003
165Osteolytic defects of the phalanges of the hand (HP:0009771)1.62531003
166Hyperbilirubinemia (HP:0002904)1.61056786
167Lower limb amyotrophy (HP:0007210)1.60338063
168Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.60156938
169Pulmonary embolism (HP:0002204)1.59687050
170Limb-girdle muscle atrophy (HP:0003797)1.59330847
171Chronic hepatic failure (HP:0100626)1.59298472
172Cupped ribs (HP:0000887)1.58739575
173Pterygium (HP:0001059)1.57986301
174Abnormality of the hip-girdle musculature (HP:0001445)1.57526787
175Abnormality of the musculature of the pelvis (HP:0001469)1.57526787
176Cerebral aneurysm (HP:0004944)1.57242538
177Skin nodule (HP:0200036)1.56636550
178Achilles tendon contracture (HP:0001771)1.55829621
179Bowel incontinence (HP:0002607)1.55575903
180Malignant gastrointestinal tract tumors (HP:0006749)1.54896006
181Gastrointestinal carcinoma (HP:0002672)1.54896006
182Abdominal distention (HP:0003270)1.54876563
183Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.54804830
184Tachypnea (HP:0002789)1.54556631
185Curly hair (HP:0002212)1.54445415
186Absent phalangeal crease (HP:0006109)1.54224178
187Abnormality of the renal cortex (HP:0011035)1.53717364
188Drooling (HP:0002307)1.53125894
189Abnormal large intestine physiology (HP:0012700)1.52706631
190Osteomalacia (HP:0002749)1.52584528
191External ophthalmoplegia (HP:0000544)1.52488533
192Hyperparathyroidism (HP:0000843)1.51532943
193Blepharitis (HP:0000498)1.51359695
194Megaloblastic anemia (HP:0001889)1.51176030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.53936296
2ERBB33.87296847
3SRPK13.11236451
4LATS13.08559644
5TAOK33.04381127
6NEK12.97031882
7CDK122.95839639
8EEF2K2.63945321
9TTK2.60499582
10INSRR2.59986292
11BRD42.52760582
12SIK12.45350149
13CDC72.42641678
14NEK92.38619969
15MAPK152.37157637
16ERN12.36889671
17SCYL22.32162250
18BCR2.28487459
19TGFBR22.14475901
20EIF2AK12.12981660
21CAMK1D2.12345171
22RIPK12.04887943
23NUAK12.03047838
24BMPR22.01128614
25LATS21.97864811
26FGFR21.94659676
27FGFR31.86718284
28RPS6KA41.72541296
29CAMK1G1.65953850
30CDK61.63920410
31PBK1.59762665
32EIF2AK31.57640999
33MST1R1.57512027
34KSR11.54048967
35TRPM71.51068588
36STK31.50243023
37TRIB31.45820290
38ICK1.44676786
39MAPKAPK31.39423666
40KSR21.38154606
41IRAK31.37547022
42FGFR41.34573155
43PTK61.33858608
44CDK91.33147184
45SMG11.31980490
46EPHA31.31312002
47NTRK11.26603476
48STK241.26295853
49BRAF1.25735865
50EPHB11.23233952
51CHEK21.21875033
52PRPF4B1.20677602
53MAP3K101.20223460
54PNCK1.19333456
55TNIK1.17274041
56PKN21.17151340
57PRKAA21.16027680
58MAP3K141.14218882
59STK38L1.13958690
60OBSCN1.10725374
61BUB11.09865926
62ARAF1.09038346
63MAPK111.08653524
64JAK11.08317407
65HIPK21.06665254
66STK161.03778071
67PDGFRA1.01141076
68MAP3K61.00854211
69CHEK11.00240579
70TYK20.99450848
71MAP3K30.98701070
72PLK10.98209421
73ATR0.94293673
74TAF10.91094931
75EPHA20.88607516
76FER0.86463634
77SGK30.85759021
78TRIM280.85096754
79CDK70.84850495
80IRAK10.84271224
81NLK0.84125093
82MET0.83793524
83SGK20.82046673
84IKBKE0.81900474
85AURKB0.81672498
86PHKG10.80463950
87PHKG20.80463950
88DYRK1B0.80061864
89MAP2K70.79084512
90CDK40.77723058
91JAK20.76087091
92CDK140.75818257
93MAP2K20.74855997
94MARK10.73663932
95MAPKAPK50.73503546
96CDK11A0.72874330
97CDK180.72054791
98PLK30.71858778
99WEE10.71461324
100RAF10.71445382
101CHUK0.70543927
102ALK0.70447929
103BRSK20.70064123
104MAP3K80.69954828
105PLK40.69638696
106EPHB20.69476591
107ATM0.68888801
108PDGFRB0.68524741
109CSK0.68344571
110CDK150.68110019
111CSNK1E0.67280290
112CDK20.66770277
113GSK3A0.66472614
114CSNK1A1L0.63578497
115MAP3K40.62419260
116MAP2K10.61957669
117EIF2AK20.61155064
118BCKDK0.60890876
119FLT30.60281285
120AKT20.60159231
121AURKA0.60132617
122CDK10.59781136
123ERBB40.59412487
124CSNK1G20.58551850
125MTOR0.55808423
126SIK30.54995255
127BRSK10.53324303
128IRAK40.52875251
129PRKAA10.52330810
130PIM10.51946778
131MAP3K90.51860746
132MAPKAPK20.51743738
133CSNK1G30.51367839
134CDK30.51125572
135DAPK20.50086999
136RPS6KA20.49577561
137RPS6KB10.48963161
138DMPK0.48503661
139CDK80.48196810
140DYRK30.48124894
141ABL10.48026727
142STK390.47059648
143MKNK10.45413547
144PAK40.45150066
145NEK20.44444239
146TSSK60.44434220
147YES10.44027787
148CSNK1G10.43265631
149MAP3K20.42739663
150TBK10.40998340
151JAK30.39857172
152MELK0.39031475
153CSF1R0.38884362
154RPS6KB20.37666965
155TTN0.37598733
156PRKCQ0.37473113
157TEC0.35741388
158PRKD10.35435044
159SGK4940.35378805
160SGK2230.35378805
161PIK3CG0.34822194
162MAP3K70.34551048
163SIK20.33679859
164PIM20.31152171
165ERBB20.30049610
166PRKCH0.29978779
167MAP2K40.29797241
168MAPK40.29298357
169ZAK0.28949689
170IGF1R0.28163354
171PRKCZ0.28014642
172BMPR1B0.27731704
173GRK10.25808494

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.99476309
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.28127591
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.06009080
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.04940679
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.91466406
6Nitrogen metabolism_Homo sapiens_hsa009102.90647276
7Fatty acid degradation_Homo sapiens_hsa000712.78917967
8Complement and coagulation cascades_Homo sapiens_hsa046102.65358316
9Cyanoamino acid metabolism_Homo sapiens_hsa004602.60292082
10Biosynthesis of amino acids_Homo sapiens_hsa012302.56986796
11Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.49042284
12PPAR signaling pathway_Homo sapiens_hsa033202.45375779
13DNA replication_Homo sapiens_hsa030302.27802281
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.24286996
15Tryptophan metabolism_Homo sapiens_hsa003802.21080880
16Caffeine metabolism_Homo sapiens_hsa002322.17988382
17Pentose and glucuronate interconversions_Homo sapiens_hsa000402.16435877
18Propanoate metabolism_Homo sapiens_hsa006402.13269771
19Arginine biosynthesis_Homo sapiens_hsa002202.12964891
20Staphylococcus aureus infection_Homo sapiens_hsa051502.08877890
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.08197764
22Sulfur metabolism_Homo sapiens_hsa009202.01992312
23Cell cycle_Homo sapiens_hsa041101.97287943
24Spliceosome_Homo sapiens_hsa030401.96556323
25mRNA surveillance pathway_Homo sapiens_hsa030151.91675706
26Histidine metabolism_Homo sapiens_hsa003401.89489773
27RNA transport_Homo sapiens_hsa030131.88971693
28Fatty acid metabolism_Homo sapiens_hsa012121.87784968
29Mismatch repair_Homo sapiens_hsa034301.74189278
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68791882
31beta-Alanine metabolism_Homo sapiens_hsa004101.68150398
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.67457523
33Chemical carcinogenesis_Homo sapiens_hsa052041.66741400
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64339437
35Fat digestion and absorption_Homo sapiens_hsa049751.63941036
36Peroxisome_Homo sapiens_hsa041461.61942605
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60576888
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.56494591
39Starch and sucrose metabolism_Homo sapiens_hsa005001.50411515
40Maturity onset diabetes of the young_Homo sapiens_hsa049501.49730716
41Fructose and mannose metabolism_Homo sapiens_hsa000511.49398476
42Base excision repair_Homo sapiens_hsa034101.49365917
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43168822
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.37213457
45ABC transporters_Homo sapiens_hsa020101.36289556
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.33371075
47Thyroid cancer_Homo sapiens_hsa052161.32090265
48Selenocompound metabolism_Homo sapiens_hsa004501.30607221
49Butanoate metabolism_Homo sapiens_hsa006501.30269738
50Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30198908
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.29096856
52Fatty acid biosynthesis_Homo sapiens_hsa000611.28130432
53Lysine degradation_Homo sapiens_hsa003101.27829941
54Retinol metabolism_Homo sapiens_hsa008301.27356893
55Glycerolipid metabolism_Homo sapiens_hsa005611.26662916
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25580822
57Folate biosynthesis_Homo sapiens_hsa007901.23099139
58Bile secretion_Homo sapiens_hsa049761.18915814
59Phenylalanine metabolism_Homo sapiens_hsa003601.14561806
60Sulfur relay system_Homo sapiens_hsa041221.12603076
61Insulin resistance_Homo sapiens_hsa049311.09284161
62Renal cell carcinoma_Homo sapiens_hsa052111.07618338
63Galactose metabolism_Homo sapiens_hsa000521.04409910
64Adipocytokine signaling pathway_Homo sapiens_hsa049201.03229636
65Pyruvate metabolism_Homo sapiens_hsa006201.01823279
66Nucleotide excision repair_Homo sapiens_hsa034200.97314851
67Tyrosine metabolism_Homo sapiens_hsa003500.96846447
68Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93057994
69Non-homologous end-joining_Homo sapiens_hsa034500.88236891
70Renin-angiotensin system_Homo sapiens_hsa046140.85461169
71Oocyte meiosis_Homo sapiens_hsa041140.82511797
72Steroid biosynthesis_Homo sapiens_hsa001000.81275330
73MicroRNAs in cancer_Homo sapiens_hsa052060.74506000
74Prostate cancer_Homo sapiens_hsa052150.72648082
75AMPK signaling pathway_Homo sapiens_hsa041520.72440294
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70458489
77Colorectal cancer_Homo sapiens_hsa052100.70295154
78ErbB signaling pathway_Homo sapiens_hsa040120.70195416
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69828413
80mTOR signaling pathway_Homo sapiens_hsa041500.68277898
81Circadian rhythm_Homo sapiens_hsa047100.68209456
82Chronic myeloid leukemia_Homo sapiens_hsa052200.67211658
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.66923388
84Hepatitis C_Homo sapiens_hsa051600.65625952
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64700512
86Vitamin B6 metabolism_Homo sapiens_hsa007500.64520283
87p53 signaling pathway_Homo sapiens_hsa041150.64497452
88Vitamin digestion and absorption_Homo sapiens_hsa049770.63867661
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60585996
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59446150
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.59437694
92Basal transcription factors_Homo sapiens_hsa030220.59097269
93Non-small cell lung cancer_Homo sapiens_hsa052230.58922354
94FoxO signaling pathway_Homo sapiens_hsa040680.58703793
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58699934
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58524466
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58504634
98Glucagon signaling pathway_Homo sapiens_hsa049220.58449493
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.57923820
100RNA degradation_Homo sapiens_hsa030180.57752878
101Viral carcinogenesis_Homo sapiens_hsa052030.57654447
102Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57426410
103Adherens junction_Homo sapiens_hsa045200.56684747
104Prion diseases_Homo sapiens_hsa050200.55669115
105Fanconi anemia pathway_Homo sapiens_hsa034600.54539473
106Tight junction_Homo sapiens_hsa045300.53074721
107Pancreatic cancer_Homo sapiens_hsa052120.52043884
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49311406
109Vibrio cholerae infection_Homo sapiens_hsa051100.49041457
110Pyrimidine metabolism_Homo sapiens_hsa002400.48108245
111Insulin signaling pathway_Homo sapiens_hsa049100.47181655
112Linoleic acid metabolism_Homo sapiens_hsa005910.46879226
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46102426
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46073136
115Systemic lupus erythematosus_Homo sapiens_hsa053220.45300553
116Protein export_Homo sapiens_hsa030600.45158036
117Toxoplasmosis_Homo sapiens_hsa051450.45157586
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43766524
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43586321
120Shigellosis_Homo sapiens_hsa051310.43238685
121Glioma_Homo sapiens_hsa052140.41102164
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39661944
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.38399781
124Bladder cancer_Homo sapiens_hsa052190.38001909
125Ovarian steroidogenesis_Homo sapiens_hsa049130.37976840
126Small cell lung cancer_Homo sapiens_hsa052220.37494940
127Pentose phosphate pathway_Homo sapiens_hsa000300.37335786
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.35506815
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.33620678
130Endometrial cancer_Homo sapiens_hsa052130.32299874
131ECM-receptor interaction_Homo sapiens_hsa045120.31254356
132Amoebiasis_Homo sapiens_hsa051460.31098920
133Arginine and proline metabolism_Homo sapiens_hsa003300.30564882
134Prolactin signaling pathway_Homo sapiens_hsa049170.30464868
135Pertussis_Homo sapiens_hsa051330.29106350
136Olfactory transduction_Homo sapiens_hsa047400.28452020
137Fatty acid elongation_Homo sapiens_hsa000620.27833085
138Carbon metabolism_Homo sapiens_hsa012000.26779721
139Glutathione metabolism_Homo sapiens_hsa004800.26294552
140Melanoma_Homo sapiens_hsa052180.26089528
141TGF-beta signaling pathway_Homo sapiens_hsa043500.25768392
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25220762
143Type II diabetes mellitus_Homo sapiens_hsa049300.25161167
144Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25079940
145Acute myeloid leukemia_Homo sapiens_hsa052210.24798240
146Protein digestion and absorption_Homo sapiens_hsa049740.24167182
147One carbon pool by folate_Homo sapiens_hsa006700.24072908
148Dorso-ventral axis formation_Homo sapiens_hsa043200.22250853
149Glycerophospholipid metabolism_Homo sapiens_hsa005640.22107141
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22053307

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