CEACAM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1defense response to fungus (GO:0050832)9.83699678
2killing of cells of other organism (GO:0031640)9.55021153
3disruption of cells of other organism (GO:0044364)9.55021153
4innate immune response in mucosa (GO:0002227)8.67518675
5antibacterial humoral response (GO:0019731)8.24931677
6mucosal immune response (GO:0002385)7.63663883
7antimicrobial humoral response (GO:0019730)7.52663634
8organ or tissue specific immune response (GO:0002251)7.10630363
9response to fungus (GO:0009620)7.03417878
10leukocyte migration involved in inflammatory response (GO:0002523)5.33782424
11positive regulation of interleukin-8 biosynthetic process (GO:0045416)5.26368013
12cellular extravasation (GO:0045123)5.18352803
13oxygen transport (GO:0015671)5.07974746
14cell killing (GO:0001906)5.03285448
15killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.99077746
16disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.99077746
17response to peptidoglycan (GO:0032494)4.95822128
18detection of bacterium (GO:0016045)4.84790502
19detection of other organism (GO:0098543)4.77426238
20neutrophil activation (GO:0042119)4.64421967
21negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.56971528
22superoxide anion generation (GO:0042554)4.54198728
23negative regulation of interleukin-8 production (GO:0032717)4.44658904
24neutrophil activation involved in immune response (GO:0002283)4.27420716
25granulocyte activation (GO:0036230)4.17073586
26defense response to Gram-positive bacterium (GO:0050830)4.14776787
27activated T cell proliferation (GO:0050798)4.10914690
28gas transport (GO:0015669)4.04551251
29fucose catabolic process (GO:0019317)4.04025855
30L-fucose metabolic process (GO:0042354)4.04025855
31L-fucose catabolic process (GO:0042355)4.04025855
32protoporphyrinogen IX biosynthetic process (GO:0006782)3.99532251
33protoporphyrinogen IX metabolic process (GO:0046501)3.94205969
34negative regulation of growth of symbiont in host (GO:0044130)3.88294519
35negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.88294519
36modulation of growth of symbiont involved in interaction with host (GO:0044144)3.88294519
37regulation of growth of symbiont in host (GO:0044126)3.88294519
38negative regulation of interleukin-6 production (GO:0032715)3.82821264
39leukocyte aggregation (GO:0070486)3.82625318
40defense response to bacterium (GO:0042742)3.70244596
41negative regulation of mast cell activation (GO:0033004)3.66955810
42behavioral response to nicotine (GO:0035095)3.56847090
43intracellular estrogen receptor signaling pathway (GO:0030520)3.48722597
44regulation of natural killer cell differentiation (GO:0032823)3.47798425
45regulation of interleukin-8 biosynthetic process (GO:0045414)3.45075350
46regulation of mast cell activation (GO:0033003)3.39164233
47regulation of female gonad development (GO:2000194)3.35577113
48response to host immune response (GO:0052572)3.32533485
49response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.32533485
50imidazole-containing compound metabolic process (GO:0052803)3.32333474
51negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.31779370
52response to methylmercury (GO:0051597)3.30725866
53phagosome maturation (GO:0090382)3.28371723
54hemoglobin metabolic process (GO:0020027)3.25902645
55response to bacterium (GO:0009617)3.21972925
56positive regulation of steroid hormone secretion (GO:2000833)3.19632194
57detection of external biotic stimulus (GO:0098581)3.18860327
58positive regulation of toll-like receptor signaling pathway (GO:0034123)3.12072596
59mast cell activation (GO:0045576)3.06771586
60porphyrin-containing compound biosynthetic process (GO:0006779)3.06206526
61respiratory burst (GO:0045730)3.03677451
62adaptation of signaling pathway (GO:0023058)3.01730635
63tetrapyrrole biosynthetic process (GO:0033014)2.99697211
64positive regulation of gamma-delta T cell activation (GO:0046645)2.95238117
65leukocyte degranulation (GO:0043299)2.88079560
66detection of biotic stimulus (GO:0009595)2.86085521
67negative regulation of interleukin-1 production (GO:0032692)2.82992001
68leukotriene biosynthetic process (GO:0019370)2.82290862
69citrulline biosynthetic process (GO:0019240)2.76865834
70regulation of mast cell degranulation (GO:0043304)2.72694438
71regulation of mast cell activation involved in immune response (GO:0033006)2.72147925
72bicarbonate transport (GO:0015701)2.71379852
73cytidine deamination (GO:0009972)2.70689430
74cytidine metabolic process (GO:0046087)2.70689430
75cytidine catabolic process (GO:0006216)2.70689430
76neutrophil chemotaxis (GO:0030593)2.70508708
77modification of morphology or physiology of other organism (GO:0035821)2.70042059
78regulation of B cell receptor signaling pathway (GO:0050855)2.69213387
79positive regulation of mast cell activation (GO:0033005)2.69147365
80response to host (GO:0075136)2.68921871
81response to host defenses (GO:0052200)2.68921871
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68921871
83regulation of feeding behavior (GO:0060259)2.68573851
84myeloid cell development (GO:0061515)2.68525366
85erythrocyte maturation (GO:0043249)2.68019199
86negative regulation of interleukin-1 beta production (GO:0032691)2.64230753
87neutrophil migration (GO:1990266)2.64010249
88neutrophil mediated immunity (GO:0002446)2.62735876
89cell wall macromolecule catabolic process (GO:0016998)2.62623679
90regulation of interleukin-8 production (GO:0032677)2.60948095
91regulation of memory T cell differentiation (GO:0043380)2.60120592
92hydrogen peroxide catabolic process (GO:0042744)2.59380139
93production of molecular mediator involved in inflammatory response (GO:0002532)2.58653478
94erythrocyte development (GO:0048821)2.58327071
95heme biosynthetic process (GO:0006783)2.57921629
96negative regulation of telomere maintenance (GO:0032205)2.57739014
97negative regulation of tumor necrosis factor production (GO:0032720)2.57689261
98preassembly of GPI anchor in ER membrane (GO:0016254)2.57450969
99granulocyte migration (GO:0097530)2.48077713
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.46814792

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.37342138
2IGF1R_20145208_ChIP-Seq_DFB_Human3.07743023
3VDR_22108803_ChIP-Seq_LS180_Human2.99829981
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.70692081
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.61822403
6GATA1_22025678_ChIP-Seq_K562_Human2.45599757
7LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.30961149
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.19286063
9SCL_19346495_ChIP-Seq_HPC-7_Human2.15883618
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01726118
11GBX2_23144817_ChIP-Seq_PC3_Human1.98949484
12EZH2_22144423_ChIP-Seq_EOC_Human1.94648512
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89208141
14TAF15_26573619_Chip-Seq_HEK293_Human1.89050375
15ER_23166858_ChIP-Seq_MCF-7_Human1.83262893
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.80296397
17GATA1_19941826_ChIP-Seq_K562_Human1.74910294
18ZFP57_27257070_Chip-Seq_ESCs_Mouse1.73671063
19ETV2_25802403_ChIP-Seq_MESCs_Mouse1.73049412
20IRF8_27001747_Chip-Seq_BMDM_Mouse1.72123970
21GATA3_26560356_Chip-Seq_TH2_Human1.69846740
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68529778
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.66386993
24PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.63311852
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.61104730
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58075412
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53640024
28TP53_22573176_ChIP-Seq_HFKS_Human1.53075716
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52472208
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.49567340
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48001124
32LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46605040
33FOXA1_27270436_Chip-Seq_PROSTATE_Human1.44597825
34FOXA1_25329375_ChIP-Seq_VCAP_Human1.44597825
35GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43692055
36VDR_24787735_ChIP-Seq_THP-1_Human1.43391162
37KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.42537946
38SPI1_23547873_ChIP-Seq_NB4_Human1.39329437
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.37822931
40AR_20517297_ChIP-Seq_VCAP_Human1.37762997
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36371437
42* GATA3_21878914_ChIP-Seq_MCF-7_Human1.36112031
43FOXA1_21572438_ChIP-Seq_LNCaP_Human1.35774582
44MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31252521
45GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.30651124
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.29919633
47IRF1_19129219_ChIP-ChIP_H3396_Human1.29169689
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28400335
49P300_19829295_ChIP-Seq_ESCs_Human1.27484493
50TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.26567195
51EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26452345
52BCAT_22108803_ChIP-Seq_LS180_Human1.26272991
53UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25464188
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23137820
55EWS_26573619_Chip-Seq_HEK293_Human1.21528111
56REST_21632747_ChIP-Seq_MESCs_Mouse1.20954262
57RUNX_20019798_ChIP-Seq_JUKART_Human1.20464918
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19993244
59DROSHA_22980978_ChIP-Seq_HELA_Human1.19749858
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19556941
61* AR_25329375_ChIP-Seq_VCAP_Human1.17857435
62SOX2_19829295_ChIP-Seq_ESCs_Human1.17827472
63NANOG_19829295_ChIP-Seq_ESCs_Human1.17827472
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.17346465
65NANOG_20526341_ChIP-Seq_ESCs_Human1.16338627
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.16303037
67GATA2_19941826_ChIP-Seq_K562_Human1.16165863
68EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.13752489
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.13396411
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.11853150
71NCOR_22424771_ChIP-Seq_293T_Human1.10362879
72MYB_26560356_Chip-Seq_TH2_Human1.10046626
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.09371433
74* SMRT_27268052_Chip-Seq_Bcells_Human1.09227188
75PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07283115
76AR_21572438_ChIP-Seq_LNCaP_Human1.06550091
77* TCF4_23295773_ChIP-Seq_U87_Human1.05480397
78PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03828739
79ERA_21632823_ChIP-Seq_H3396_Human1.03517724
80STAT3_23295773_ChIP-Seq_U87_Human1.03078795
81* OCT1_27270436_Chip-Seq_PROSTATE_Human1.02542872
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02298905
83TAF2_19829295_ChIP-Seq_ESCs_Human1.01941776
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.01738531
85OCT4_20526341_ChIP-Seq_ESCs_Human1.01346055
86VDR_24763502_ChIP-Seq_THP-1_Human1.01283565
87HOXB7_26014856_ChIP-Seq_BT474_Human1.00586075
88* RUNX2_22187159_ChIP-Seq_PCA_Human0.99704407
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.99529073
90HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.98392494
91IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97416409
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96732002
93EZH2_27294783_Chip-Seq_NPCs_Mouse0.96616737
94FUS_26573619_Chip-Seq_HEK293_Human0.96488748
95GATA3_26560356_Chip-Seq_TH1_Human0.95747563
96POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95546934
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95546934
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94508555
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.93948986
100PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93872110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level4.67117674
2MP0003656_abnormal_erythrocyte_physiolo3.30226597
3MP0003724_increased_susceptibility_to2.92067015
4MP0009785_altered_susceptibility_to2.89219077
5MP0001986_abnormal_taste_sensitivity2.38637468
6MP0003303_peritoneal_inflammation2.37645540
7MP0000569_abnormal_digit_pigmentation2.35868116
8MP0002419_abnormal_innate_immunity2.34597885
9MP0005025_abnormal_response_to2.31692505
10MP0000685_abnormal_immune_system2.23247178
11MP0003436_decreased_susceptibility_to2.22205969
12MP0003011_delayed_dark_adaptation2.17236994
13MP0003172_abnormal_lysosome_physiology2.10197692
14MP0002138_abnormal_hepatobiliary_system2.09841267
15MP0005083_abnormal_biliary_tract1.97884796
16MP0003195_calcinosis1.77701005
17MP0005075_abnormal_melanosome_morpholog1.75791799
18MP0003646_muscle_fatigue1.70952473
19MP0001835_abnormal_antigen_presentation1.69672007
20MP0005174_abnormal_tail_pigmentation1.68661766
21MP0005464_abnormal_platelet_physiology1.67060533
22MP0005671_abnormal_response_to1.65927617
23MP0008872_abnormal_physiological_respon1.65386896
24MP0002148_abnormal_hypersensitivity_rea1.63794010
25MP0009764_decreased_sensitivity_to1.60023873
26MP0001800_abnormal_humoral_immune1.59273194
27MP0001790_abnormal_immune_system1.58882577
28MP0005387_immune_system_phenotype1.58882577
29MP0002420_abnormal_adaptive_immunity1.55116762
30MP0001819_abnormal_immune_cell1.54123185
31MP0005000_abnormal_immune_tolerance1.48881116
32MP0002452_abnormal_antigen_presenting1.48565068
33MP0002095_abnormal_skin_pigmentation1.48561253
34MP0005084_abnormal_gallbladder_morpholo1.48350940
35MP0008877_abnormal_DNA_methylation1.48333415
36MP0000015_abnormal_ear_pigmentation1.43463687
37MP0002723_abnormal_immune_serum1.42954008
38MP0009046_muscle_twitch1.40263547
39MP0004142_abnormal_muscle_tone1.36766921
40MP0009278_abnormal_bone_marrow1.36005787
41MP0002102_abnormal_ear_morphology1.34170430
42MP0005551_abnormal_eye_electrophysiolog1.30815591
43MP0001545_abnormal_hematopoietic_system1.29343672
44MP0005397_hematopoietic_system_phenotyp1.29343672
45MP0008875_abnormal_xenobiotic_pharmacok1.26300165
46MP0000689_abnormal_spleen_morphology1.24881195
47MP0001533_abnormal_skeleton_physiology1.22141531
48MP0001845_abnormal_inflammatory_respons1.21966477
49MP0003183_abnormal_peptide_metabolism1.17816855
50MP0002398_abnormal_bone_marrow1.17604074
51MP0005253_abnormal_eye_physiology1.15702196
52MP0004130_abnormal_muscle_cell1.15558804
53MP0002405_respiratory_system_inflammati1.12774157
54MP0005636_abnormal_mineral_homeostasis1.11561518
55MP0000716_abnormal_immune_system1.11147564
56MP0005645_abnormal_hypothalamus_physiol1.10079293
57MP0002722_abnormal_immune_system1.09438252
58MP0009745_abnormal_behavioral_response1.07989073
59MP0003045_fibrosis1.03862545
60MP0002876_abnormal_thyroid_physiology1.03753369
61MP0000465_gastrointestinal_hemorrhage1.03091983
62MP0002277_abnormal_respiratory_mucosa1.01451326
63MP0001919_abnormal_reproductive_system1.00187334
64MP0002837_dystrophic_cardiac_calcinosis0.99546016
65MP0001486_abnormal_startle_reflex0.98884342
66MP0001968_abnormal_touch/_nociception0.97996210
67MP0004742_abnormal_vestibular_system0.97153202
68MP0003950_abnormal_plasma_membrane0.97059398
69MP0002429_abnormal_blood_cell0.96808771
70MP0004885_abnormal_endolymph0.94167832
71MP0002733_abnormal_thermal_nociception0.92879849
72MP0005310_abnormal_salivary_gland0.92834977
73MP0000230_abnormal_systemic_arterial0.92582097
74MP0002653_abnormal_ependyma_morphology0.92203951
75MP0004145_abnormal_muscle_electrophysio0.88316622
76MP0003136_yellow_coat_color0.88276803
77MP0001485_abnormal_pinna_reflex0.87205787
78MP0008775_abnormal_heart_ventricle0.85030933
79MP0005646_abnormal_pituitary_gland0.84627645
80MP0001663_abnormal_digestive_system0.84055861
81MP0003828_pulmonary_edema0.83933111
82MP0001970_abnormal_pain_threshold0.83479412
83MP0000371_diluted_coat_color0.82209604
84MP0005167_abnormal_blood-brain_barrier0.81446075
85MP0002693_abnormal_pancreas_physiology0.81256617
86MP0002638_abnormal_pupillary_reflex0.80075751
87MP0002064_seizures0.79287885
88MP0006082_CNS_inflammation0.78636252
89MP0001873_stomach_inflammation0.78243567
90MP0000427_abnormal_hair_cycle0.78159225
91MP0005410_abnormal_fertilization0.77491587
92MP0005448_abnormal_energy_balance0.77255690
93MP0009765_abnormal_xenobiotic_induced0.76664203
94MP0005389_reproductive_system_phenotype0.75689573
95MP0006276_abnormal_autonomic_nervous0.74256995
96MP0001764_abnormal_homeostasis0.73490287
97MP0005377_hearing/vestibular/ear_phenot0.73066506
98MP0003878_abnormal_ear_physiology0.73066506
99MP0001324_abnormal_eye_pigmentation0.72717347
100MP0010386_abnormal_urinary_bladder0.72633372

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)7.21739562
2Abnormality of the heme biosynthetic pathway (HP:0010472)6.52597487
3Hypochromic anemia (HP:0001931)4.41044510
4Stomatitis (HP:0010280)4.32604969
5Poikilocytosis (HP:0004447)4.02987002
6Microcytic anemia (HP:0001935)3.62781705
7Congenital stationary night blindness (HP:0007642)3.46073723
8Recurrent abscess formation (HP:0002722)3.44740591
9Recurrent bacterial skin infections (HP:0005406)3.36557766
10Abnormal delayed hypersensitivity skin test (HP:0002963)3.22886993
11Abnormal hemoglobin (HP:0011902)3.00854606
12Paralysis (HP:0003470)2.89177208
13Pancreatic cysts (HP:0001737)2.89102399
14Abolished electroretinogram (ERG) (HP:0000550)2.86535269
15Increased neuronal autofluorescent lipopigment (HP:0002074)2.85711933
16Prolonged bleeding time (HP:0003010)2.78816621
17Stomach cancer (HP:0012126)2.78381380
18Abnormality of midbrain morphology (HP:0002418)2.75957154
19Molar tooth sign on MRI (HP:0002419)2.75957154
20Abnormality of glycolipid metabolism (HP:0010969)2.69896459
21Abnormality of liposaccharide metabolism (HP:0010968)2.69896459
22Abnormality of glycosphingolipid metabolism (HP:0004343)2.69896459
23Recurrent gram-negative bacterial infections (HP:0005420)2.68221424
24Myositis (HP:0100614)2.67798434
25Eczematoid dermatitis (HP:0000976)2.58570272
26Abnormality of transition element cation homeostasis (HP:0011030)2.56422030
27Abnormality of macrophages (HP:0004311)2.55953292
28Abnormality of B cell number (HP:0010975)2.55895105
29Retrobulbar optic neuritis (HP:0100654)2.54696542
30Optic neuritis (HP:0100653)2.54696542
31Aplasia/Hypoplasia of the fovea (HP:0008060)2.52566750
32Hypoplasia of the fovea (HP:0007750)2.52566750
33Increased cerebral lipofuscin (HP:0011813)2.48905322
34Autoimmune thrombocytopenia (HP:0001973)2.48666674
35Recurrent fungal infections (HP:0002841)2.48255101
36Abnormality of iron homeostasis (HP:0011031)2.48104548
37Chronic obstructive pulmonary disease (HP:0006510)2.47543654
38Obstructive lung disease (HP:0006536)2.47543654
39Toxemia of pregnancy (HP:0100603)2.42232065
40Agitation (HP:0000713)2.35805325
41Nephronophthisis (HP:0000090)2.34853103
42Decreased central vision (HP:0007663)2.34716168
43Recurrent skin infections (HP:0001581)2.30657209
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30508115
45Attenuation of retinal blood vessels (HP:0007843)2.28947749
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28736253
47Decreased circulating renin level (HP:0003351)2.25868157
48Progressive cerebellar ataxia (HP:0002073)2.24005337
49Mediastinal lymphadenopathy (HP:0100721)2.23799960
50Elevated erythrocyte sedimentation rate (HP:0003565)2.23250386
51True hermaphroditism (HP:0010459)2.23099249
52Petechiae (HP:0000967)2.21364667
53Large for gestational age (HP:0001520)2.17910796
54Pancreatic fibrosis (HP:0100732)2.17597134
55Recurrent cutaneous fungal infections (HP:0011370)2.16290884
56Chronic mucocutaneous candidiasis (HP:0002728)2.16290884
57Keratoconjunctivitis (HP:0001096)2.16082455
58Abnormality of the renal cortex (HP:0011035)2.15352087
59Abnormal drinking behavior (HP:0030082)2.15198853
60Polydipsia (HP:0001959)2.15198853
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.14533031
62Absent/shortened dynein arms (HP:0200106)2.14533031
63Orchitis (HP:0100796)2.12603172
64Hemoptysis (HP:0002105)2.09052024
65Pulmonary infiltrates (HP:0002113)2.06810849
66Gastrointestinal infarctions (HP:0005244)2.04642169
67Abnormality of T cell physiology (HP:0011840)2.04580137
68Keratoconjunctivitis sicca (HP:0001097)2.02681702
69Gingivitis (HP:0000230)2.02515290
70Genetic anticipation (HP:0003743)2.02335028
71Albinism (HP:0001022)2.02216343
72Abnormality of binocular vision (HP:0011514)2.00091112
73Diplopia (HP:0000651)2.00091112
74Abnormal rod and cone electroretinograms (HP:0008323)2.00016966
75Anorexia (HP:0002039)1.99796933
76Partial agenesis of the corpus callosum (HP:0001338)1.99272348
77Abnormality of the fovea (HP:0000493)1.97750601
78Epistaxis (HP:0000421)1.96256485
79Abnormality of the prostate (HP:0008775)1.94353607
80Polyphagia (HP:0002591)1.94152070
81Gaze-evoked nystagmus (HP:0000640)1.93125063
82Meningitis (HP:0001287)1.92010028
83B lymphocytopenia (HP:0010976)1.91591018
84Severe visual impairment (HP:0001141)1.90678392
85Polycythemia (HP:0001901)1.90418173
86Urticaria (HP:0001025)1.89322867
87Chronic hepatic failure (HP:0100626)1.89270749
88Abnormality of the renal medulla (HP:0100957)1.86962582
89Pustule (HP:0200039)1.85697298
90Aplasia/Hypoplasia of the macula (HP:0008059)1.84369251
91Prostate neoplasm (HP:0100787)1.82521366
92Cerebral palsy (HP:0100021)1.82086812
93Inability to walk (HP:0002540)1.81684179
943-Methylglutaconic aciduria (HP:0003535)1.80543681
95Clumsiness (HP:0002312)1.79766490
96Encephalitis (HP:0002383)1.79133799
97Tinnitus (HP:0000360)1.78573383
98Pendular nystagmus (HP:0012043)1.77554393
99Medial flaring of the eyebrow (HP:0010747)1.75658678
100Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75378943

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.05588696
2ZAK2.61452052
3TXK2.59613824
4ADRBK22.59310168
5RIPK42.57464623
6MAP2K32.49593040
7GRK62.46993191
8BLK2.34804963
9TAOK32.31121426
10TLK12.03763948
11TEC1.99626693
12TNK21.91000644
13SYK1.89755429
14GRK11.84567557
15IRAK41.81230833
16ACVR1B1.80766676
17INSRR1.80171255
18BMPR1B1.78595994
19PIK3CA1.76240135
20DAPK21.73697657
21PINK11.66875750
22OXSR11.58845775
23NUAK11.53084823
24CAMKK21.49534298
25MAPK131.48156889
26MAP4K11.47658242
27PTK2B1.43674534
28WNK31.41464235
29BTK1.35890819
30PIK3CG1.31969107
31FES1.31368284
32TAOK11.28066890
33ITK1.28020437
34ZAP701.19817741
35MAP4K21.18424871
36MAP2K61.18389051
37LYN1.18115853
38MAP3K111.15369414
39MAP3K61.07501118
40SIK21.06904478
41MAP2K41.02968570
42TRPM71.02929028
43KIT1.02652870
44STK111.00807125
45IRAK10.98936134
46IKBKB0.96612500
47BRSK20.96299386
48ADRBK10.94093715
49HCK0.91337150
50HIPK20.86685577
51WNK40.86097326
52FGR0.85905237
53PRKG20.83018993
54WNK10.80602765
55DYRK20.73446822
56MAP2K10.73189966
57LCK0.72428115
58PRKCQ0.71172567
59PAK30.69807420
60JAK20.69422008
61GRK50.69159078
62MAPKAPK30.63785573
63MARK30.63378879
64PDK20.63181590
65EPHA30.63067458
66NTRK30.61358532
67CDK190.61226740
68CSK0.59286170
69PRKAA20.57505549
70IKBKE0.56176551
71MAP3K50.55907871
72TIE10.55131269
73CSF1R0.49702059
74MAP3K30.47742942
75MAPK120.46340405
76CASK0.45588657
77RPS6KA50.44669180
78VRK10.43625877
79GRK70.42266276
80MAP3K40.41591236
81MAP2K20.41531002
82PIM10.41086183
83MKNK20.39897517
84MAPK150.38278863
85RPS6KA60.38209664
86YES10.37189859
87PDK10.36407489
88CLK10.36002418
89BMPR20.34490077
90ERBB20.34148364
91ABL10.33512639
92FLT30.33456693
93DYRK1A0.32914440
94CSNK1G20.32782588
95PRKCG0.32638364
96PRKAA10.32163426
97EIF2AK20.31017757
98PRKCZ0.30098792
99PRKG10.29263005
100MAPKAPK50.27598987

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.19128986
2Asthma_Homo sapiens_hsa053102.79107626
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.71801979
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.42183043
5Malaria_Homo sapiens_hsa051442.38501395
6Regulation of autophagy_Homo sapiens_hsa041402.21483024
7Collecting duct acid secretion_Homo sapiens_hsa049662.08791058
8Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.00554466
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.97814946
10African trypanosomiasis_Homo sapiens_hsa051431.97323170
11Staphylococcus aureus infection_Homo sapiens_hsa051501.97192016
12Selenocompound metabolism_Homo sapiens_hsa004501.95506340
13Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.90741955
14Phototransduction_Homo sapiens_hsa047441.79315633
15Ether lipid metabolism_Homo sapiens_hsa005651.71224166
16Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.70649074
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.68938148
18Linoleic acid metabolism_Homo sapiens_hsa005911.65300937
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64358387
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63794466
21Hematopoietic cell lineage_Homo sapiens_hsa046401.57205499
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.56320326
23Olfactory transduction_Homo sapiens_hsa047401.45180343
24Osteoclast differentiation_Homo sapiens_hsa043801.40846671
25Morphine addiction_Homo sapiens_hsa050321.39679922
26Tuberculosis_Homo sapiens_hsa051521.34314028
27Primary immunodeficiency_Homo sapiens_hsa053401.29330653
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.27926665
29Leishmaniasis_Homo sapiens_hsa051401.27791723
30Arachidonic acid metabolism_Homo sapiens_hsa005901.27690788
31Legionellosis_Homo sapiens_hsa051341.25023218
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24000983
33ABC transporters_Homo sapiens_hsa020101.23477084
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.19502182
35Salivary secretion_Homo sapiens_hsa049701.14983246
36Oxidative phosphorylation_Homo sapiens_hsa001901.14951216
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.13436153
38Lysosome_Homo sapiens_hsa041421.11942404
39Butanoate metabolism_Homo sapiens_hsa006501.11147772
40Rheumatoid arthritis_Homo sapiens_hsa053231.06808928
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.05757609
42Tryptophan metabolism_Homo sapiens_hsa003801.05684082
43Caffeine metabolism_Homo sapiens_hsa002321.05334415
44Platelet activation_Homo sapiens_hsa046111.03965486
45Nicotine addiction_Homo sapiens_hsa050331.03893454
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.97142459
47Glycerolipid metabolism_Homo sapiens_hsa005610.90793504
48Chemokine signaling pathway_Homo sapiens_hsa040620.89174255
49GABAergic synapse_Homo sapiens_hsa047270.88615154
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86705422
51Serotonergic synapse_Homo sapiens_hsa047260.86509640
52Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.86096149
53Type II diabetes mellitus_Homo sapiens_hsa049300.86013641
54Taste transduction_Homo sapiens_hsa047420.86010854
55Circadian entrainment_Homo sapiens_hsa047130.85011381
56Phagosome_Homo sapiens_hsa041450.82918792
57Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81469483
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81238842
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78441848
60Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.78418127
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75015458
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74130048
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.72803436
64Dorso-ventral axis formation_Homo sapiens_hsa043200.72132614
65B cell receptor signaling pathway_Homo sapiens_hsa046620.70530752
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.70292784
67Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70126989
68Parkinsons disease_Homo sapiens_hsa050120.69852601
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.69808441
70Graft-versus-host disease_Homo sapiens_hsa053320.68731768
71Ovarian steroidogenesis_Homo sapiens_hsa049130.68681828
72Glycerophospholipid metabolism_Homo sapiens_hsa005640.68636969
73Peroxisome_Homo sapiens_hsa041460.68227560
74Cholinergic synapse_Homo sapiens_hsa047250.64809261
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64332530
76Homologous recombination_Homo sapiens_hsa034400.63809902
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63527752
78Sphingolipid metabolism_Homo sapiens_hsa006000.63155519
79Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61439744
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61053894
81T cell receptor signaling pathway_Homo sapiens_hsa046600.54754336
82RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49327833
83TNF signaling pathway_Homo sapiens_hsa046680.49269375
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48169504
85Autoimmune thyroid disease_Homo sapiens_hsa053200.43812908
86Chemical carcinogenesis_Homo sapiens_hsa052040.43719171
87Insulin secretion_Homo sapiens_hsa049110.43708598
88Glutamatergic synapse_Homo sapiens_hsa047240.43683424
89Type I diabetes mellitus_Homo sapiens_hsa049400.43493570
90Calcium signaling pathway_Homo sapiens_hsa040200.40980320
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40831245
92Allograft rejection_Homo sapiens_hsa053300.39709340
93Pertussis_Homo sapiens_hsa051330.39267375
94Gastric acid secretion_Homo sapiens_hsa049710.38367015
95Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37425975
96Protein export_Homo sapiens_hsa030600.35403612
97Sulfur metabolism_Homo sapiens_hsa009200.33558380
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.33212118
99Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32782055
100Long-term depression_Homo sapiens_hsa047300.31995304

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