CEACAM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bicarbonate transport (GO:0015701)9.23351499
2sulfate transmembrane transport (GO:1902358)8.44107157
3transepithelial transport (GO:0070633)7.20920331
4sulfate transport (GO:0008272)7.14713070
5calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)6.76197413
6transcytosis (GO:0045056)6.76094324
7regulation of intracellular pH (GO:0051453)6.56733719
8positive regulation of respiratory burst (GO:0060267)6.32658048
9regulation of cellular pH (GO:0030641)6.10246484
10bundle of His cell to Purkinje myocyte communication (GO:0086069)5.75435516
11cellular glucuronidation (GO:0052695)5.39586085
12pyrimidine-containing compound transmembrane transport (GO:0072531)5.20679101
13glucuronate metabolic process (GO:0019585)5.14714471
14uronic acid metabolic process (GO:0006063)5.14714471
15oligosaccharide biosynthetic process (GO:0009312)5.13863544
16regulation of pH (GO:0006885)5.06650709
17intestinal absorption (GO:0050892)4.79164247
18membrane hyperpolarization (GO:0060081)4.73512635
19positive regulation of synaptic transmission, GABAergic (GO:0032230)4.71347426
20regulation of respiratory burst (GO:0060263)4.67797742
21cellular monovalent inorganic cation homeostasis (GO:0030004)4.58260260
22negative regulation of myotube differentiation (GO:0010832)4.58241386
23positive regulation of fatty acid beta-oxidation (GO:0032000)4.37769364
24glomerular filtration (GO:0003094)4.35418127
25regulation of interleukin-8 secretion (GO:2000482)4.34316054
26regulation of apoptotic process involved in morphogenesis (GO:1902337)4.33818451
27flavonoid metabolic process (GO:0009812)4.23190170
28ethanol oxidation (GO:0006069)4.12273089
29regulation of guanylate cyclase activity (GO:0031282)4.05807512
30monovalent inorganic cation homeostasis (GO:0055067)4.04072772
31cellular response to cAMP (GO:0071320)4.01885377
323-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.98306556
33purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.98306556
34glucocorticoid biosynthetic process (GO:0006704)3.96606421
35desmosome organization (GO:0002934)3.95250930
36renal filtration (GO:0097205)3.94647419
37renal system process involved in regulation of blood volume (GO:0001977)3.92389208
38one-carbon metabolic process (GO:0006730)3.88528465
39negative regulation of complement activation (GO:0045916)3.88005191
40maintenance of gastrointestinal epithelium (GO:0030277)3.86517943
41bile acid and bile salt transport (GO:0015721)3.82226642
42positive regulation of vasodilation (GO:0045909)3.73148253
43positive regulation of pseudopodium assembly (GO:0031274)3.66771631
44sulfur compound transport (GO:0072348)3.63514946
45positive regulation of fatty acid oxidation (GO:0046321)3.60062228
46negative regulation of leukocyte chemotaxis (GO:0002689)3.57963286
47regulation of vitamin metabolic process (GO:0030656)3.57849874
48sulfur amino acid catabolic process (GO:0000098)3.54818545
49positive regulation of actin filament depolymerization (GO:0030836)3.51635097
50nucleoside diphosphate biosynthetic process (GO:0009133)3.51295122
51negative regulation of interleukin-8 production (GO:0032717)3.43807268
52negative regulation of protein activation cascade (GO:2000258)3.41961803
53cellular response to pH (GO:0071467)3.41393883
54regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.35030126
55endocrine process (GO:0050886)3.35030126
56regulation of systemic arterial blood pressure by hormone (GO:0001990)3.35030126
57O-glycan processing (GO:0016266)3.33978399
58vasodilation (GO:0042311)3.29844409
59regulation of pseudopodium assembly (GO:0031272)3.29223532
60water transport (GO:0006833)3.26568833
61ethanol metabolic process (GO:0006067)3.20825694
62auditory receptor cell differentiation (GO:0042491)3.18733502
63response to food (GO:0032094)3.18612250
64regulation of cholesterol homeostasis (GO:2000188)3.15345329
65response to acidic pH (GO:0010447)3.15090370
66ventricular cardiac muscle cell action potential (GO:0086005)3.14121388
67intestinal epithelial cell development (GO:0060576)3.13393789
68positive regulation of glycoprotein biosynthetic process (GO:0010560)3.13160401
69fluid transport (GO:0042044)3.08943843
70chloride transmembrane transport (GO:1902476)3.07558022
71negative regulation of humoral immune response (GO:0002921)2.98990155
72cobalamin metabolic process (GO:0009235)2.96609027
73UDP-N-acetylglucosamine metabolic process (GO:0006047)2.95443890
74thrombin receptor signaling pathway (GO:0070493)2.94488664
75regulation of protein glycosylation (GO:0060049)2.94184173
76negative regulation of glycoprotein metabolic process (GO:1903019)2.93203477
77excretion (GO:0007588)2.92616462
78inorganic anion transmembrane transport (GO:0098661)2.90669639
79sodium ion homeostasis (GO:0055078)2.89864071
80regulation of cellular extravasation (GO:0002691)2.89662061
81lipid translocation (GO:0034204)2.88070157
82phospholipid translocation (GO:0045332)2.88070157
83labyrinthine layer development (GO:0060711)2.86927854
84nonribosomal peptide biosynthetic process (GO:0019184)2.84275261
85regulation of systemic arterial blood pressure (GO:0003073)2.84111340
86positive regulation of glycoprotein metabolic process (GO:1903020)2.82816595
87chloride transport (GO:0006821)2.82347190
88regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.82231221
89regulation of viral entry into host cell (GO:0046596)2.80102374
90regulation of viral release from host cell (GO:1902186)2.79612229
91membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.79283716
92negative regulation of keratinocyte proliferation (GO:0010839)2.77970074
93epithelial structure maintenance (GO:0010669)2.77813308
94negative regulation of transcription by competitive promoter binding (GO:0010944)2.75887967
95negative regulation of hormone metabolic process (GO:0032351)2.75646054
96fucosylation (GO:0036065)2.75219421
97renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.73597275
98regulation of fatty acid beta-oxidation (GO:0031998)2.73364225
99actin filament depolymerization (GO:0030042)2.72655331
100sperm capacitation (GO:0048240)10.1322953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.60196134
2FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.87431880
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.70613651
4SOX2_20726797_ChIP-Seq_SW620_Human3.49683011
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.32142432
6SOX2_27498859_Chip-Seq_STOMACH_Mouse3.18346312
7FOXO3_23340844_ChIP-Seq_DLD1_Human3.01646901
8CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.90530622
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.78313765
10GATA4_25053715_ChIP-Seq_YYC3_Human2.67387313
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.64685575
12GATA6_25053715_ChIP-Seq_YYC3_Human2.56943232
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.54551451
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.53240292
15EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42815454
16ESR2_21235772_ChIP-Seq_MCF-7_Human2.41700317
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.37878331
18AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.20635163
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19818004
20PPAR_26484153_Chip-Seq_NCI-H1993_Human2.13501514
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.07673109
22FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.05910687
23STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.05876261
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.93543157
25TCF4_18268006_ChIP-ChIP_LS174T_Human1.90650442
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.84362866
27ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.83124072
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82253583
29CDX2_22108803_ChIP-Seq_LS180_Human1.82252004
30LXR_22158963_ChIP-Seq_LIVER_Mouse1.77850477
31HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70978257
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.70250433
33* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.66960248
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.66133623
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.65336595
36FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.59055515
37FOXA1_25552417_ChIP-Seq_VCAP_Human1.55550749
38FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44349579
39TP53_16413492_ChIP-PET_HCT116_Human1.43919955
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.41663600
41FOXA1_21572438_ChIP-Seq_LNCaP_Human1.41652564
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.39030815
43ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38830643
44GATA3_24758297_ChIP-Seq_MCF-7_Human1.38822274
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.35442217
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.33073559
47CEBPB_22108803_ChIP-Seq_LS180_Human1.32585519
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.32096110
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.29569068
50CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24224410
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23469049
52EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22626414
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.21468813
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.19550834
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.17777307
56NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.17695557
57FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.17494399
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.16736764
59AHR_22903824_ChIP-Seq_MCF-7_Human1.16585585
60STAT1_20625510_ChIP-Seq_HELA_Human1.15466496
61SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.14301107
62SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.14301107
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12544214
64KLF5_25053715_ChIP-Seq_YYC3_Human1.12510208
65CJUN_26792858_Chip-Seq_BT549_Human1.11871797
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.09262159
67P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08741677
68PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.07596620
69CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07511814
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04761917
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03680131
72ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01957714
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01007632
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.97409634
75DROSHA_22980978_ChIP-Seq_HELA_Human0.95904992
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.95290856
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94213392
78HNF4A_19822575_ChIP-Seq_HepG2_Human0.92689225
79RACK7_27058665_Chip-Seq_MCF-7_Human0.92581847
80EP300_21415370_ChIP-Seq_HL-1_Mouse0.91629349
81TP63_23658742_ChIP-Seq_EP156T_Human0.90806159
82GATA2_21666600_ChIP-Seq_HMVEC_Human0.90699637
83GATA1_26923725_Chip-Seq_HPCs_Mouse0.89496715
84BCAT_22108803_ChIP-Seq_LS180_Human0.88119820
85JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87118784
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.86873929
87RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86410661
88CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86204628
89PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.86196387
90JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85792510
91GATA2_19941826_ChIP-Seq_K562_Human0.84722958
92GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.84211227
93RXR_22108803_ChIP-Seq_LS180_Human0.79676951
94BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.79418063
95GBX2_23144817_ChIP-Seq_PC3_Human0.78889415
96ESR1_20079471_ChIP-ChIP_T-47D_Human0.78541874
97AR_21909140_ChIP-Seq_LNCAP_Human0.77260107
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74382585
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.71042605
100VDR_22108803_ChIP-Seq_LS180_Human0.68362407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer6.31795884
2MP0002139_abnormal_hepatobiliary_system5.81265375
3MP0002163_abnormal_gland_morphology5.55172442
4MP0002138_abnormal_hepatobiliary_system4.98406853
5MP0004043_abnormal_pH_regulation4.57713731
6MP0002132_abnormal_respiratory_system4.46275932
7MP0010234_abnormal_vibrissa_follicle3.96263834
8MP0010386_abnormal_urinary_bladder3.73084217
9MP0002277_abnormal_respiratory_mucosa3.46693749
10MP0005379_endocrine/exocrine_gland_phen3.10831316
11MP0003866_abnormal_defecation2.99100723
12MP0001664_abnormal_digestion2.85475280
13MP0000462_abnormal_digestive_system2.73668933
14MP0010352_gastrointestinal_tract_polyps2.56227311
15MP0001663_abnormal_digestive_system2.51153844
16MP0003724_increased_susceptibility_to2.23017813
17MP0008004_abnormal_stomach_pH2.21375870
18MP0005220_abnormal_exocrine_pancreas2.21242764
19MP0005365_abnormal_bile_salt2.14804497
20MP0005381_digestive/alimentary_phenotyp2.09523085
21MP0003252_abnormal_bile_duct2.08196791
22MP0005085_abnormal_gallbladder_physiolo2.07518156
23MP0003283_abnormal_digestive_organ2.02919504
24MP0002089_abnormal_postnatal_growth/wei2.02705741
25MP0001873_stomach_inflammation2.00132676
26MP0001765_abnormal_ion_homeostasis1.96556824
27MP0000477_abnormal_intestine_morphology1.91370871
28MP0002876_abnormal_thyroid_physiology1.90840969
29MP0000613_abnormal_salivary_gland1.89160539
30MP0003868_abnormal_feces_composition1.87572899
31MP0008872_abnormal_physiological_respon1.75085457
32MP0005670_abnormal_white_adipose1.62258727
33MP0000490_abnormal_crypts_of1.55600889
34MP0010155_abnormal_intestine_physiology1.49784449
35MP0002928_abnormal_bile_duct1.41394311
36MP0005636_abnormal_mineral_homeostasis1.37776896
37MP0005166_decreased_susceptibility_to1.23360795
38MP0004264_abnormal_extraembryonic_tissu1.21600953
39MP0009785_altered_susceptibility_to1.20956404
40MP0005084_abnormal_gallbladder_morpholo1.19558915
41MP0001666_abnormal_nutrient_absorption1.11263174
42MP0003045_fibrosis1.09748698
43MP0002796_impaired_skin_barrier1.04906957
44MP0003183_abnormal_peptide_metabolism1.00138344
45MP0001270_distended_abdomen0.99309250
46MP0001756_abnormal_urination0.98416780
47MP0004147_increased_porphyrin_level0.98059183
48MP0000538_abnormal_urinary_bladder0.92433155
49MP0002009_preneoplasia0.90292528
50MP0004782_abnormal_surfactant_physiolog0.87624775
51MP0005083_abnormal_biliary_tract0.82133216
52MP0005025_abnormal_response_to0.81037830
53MP0009379_abnormal_foot_pigmentation0.79957698
54MP0003950_abnormal_plasma_membrane0.78604552
55MP0002136_abnormal_kidney_physiology0.78051016
56MP0000230_abnormal_systemic_arterial0.77281475
57MP0005319_abnormal_enzyme/_coenzyme0.74208210
58MP0000467_abnormal_esophagus_morphology0.73095041
59MP0000537_abnormal_urethra_morphology0.71432531
60MP0005310_abnormal_salivary_gland0.71258894
61MP0005165_increased_susceptibility_to0.71230444
62MP0000470_abnormal_stomach_morphology0.70846888
63MP0008875_abnormal_xenobiotic_pharmacok0.70728051
64MP0005410_abnormal_fertilization0.70545517
65MP0009643_abnormal_urine_homeostasis0.69338264
66MP0010678_abnormal_skin_adnexa0.63335570
67MP0000465_gastrointestinal_hemorrhage0.63196318
68MP0003763_abnormal_thymus_physiology0.61632731
69MP0009780_abnormal_chondrocyte_physiolo0.61572223
70MP0002166_altered_tumor_susceptibility0.61314981
71MP0005023_abnormal_wound_healing0.60443440
72MP0002098_abnormal_vibrissa_morphology0.59126250
73MP0001845_abnormal_inflammatory_respons0.58091474
74MP0005501_abnormal_skin_physiology0.57519675
75MP0001533_abnormal_skeleton_physiology0.54562114
76MP0005666_abnormal_adipose_tissue0.53549117
77MP0002006_tumorigenesis0.53188851
78MP0004484_altered_response_of0.52405393
79MP0005595_abnormal_vascular_smooth0.50638748
80MP0001944_abnormal_pancreas_morphology0.50254555
81MP0002118_abnormal_lipid_homeostasis0.50024486
82MP0003436_decreased_susceptibility_to0.49387716
83MP0003195_calcinosis0.48314968
84MP0003943_abnormal_hepatobiliary_system0.47943736
85MP0000609_abnormal_liver_physiology0.47927697
86MP0004019_abnormal_vitamin_homeostasis0.47640378
87MP0006054_spinal_hemorrhage0.44729069
88MP0005387_immune_system_phenotype0.43867575
89MP0001790_abnormal_immune_system0.43867575
90MP0002168_other_aberrant_phenotype0.43183343
91MP0004947_skin_inflammation0.40860095
92MP0001216_abnormal_epidermal_layer0.40468517
93MP0002127_abnormal_cardiovascular_syste0.39245440
94MP0001485_abnormal_pinna_reflex0.38898015
95MP0000566_synostosis0.38581710
96MP0001177_atelectasis0.36131973
97MP0003953_abnormal_hormone_level0.35644498
98MP0001764_abnormal_homeostasis0.33386688
99MP0000377_abnormal_hair_follicle0.32009535
100MP0002148_abnormal_hypersensitivity_rea0.31662885

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)9.64700675
2Ileus (HP:0002595)9.62702839
3Abnormality of chloride homeostasis (HP:0011422)9.54790620
4Rectal prolapse (HP:0002035)8.04266803
5Metabolic alkalosis (HP:0200114)7.15261450
6Abnormality of renin-angiotensin system (HP:0000847)6.58828853
7Decreased circulating renin level (HP:0003351)6.41115036
8Exocrine pancreatic insufficiency (HP:0001738)5.86873297
9Male infertility (HP:0003251)5.72474314
10Abnormality of the right ventricle (HP:0001707)5.39354736
11Hyperaldosteronism (HP:0000859)5.13147779
12Flat acetabular roof (HP:0003180)4.80392623
13Azoospermia (HP:0000027)4.63495716
14Abnormal biliary tract morphology (HP:0012440)4.48875499
15Right ventricular cardiomyopathy (HP:0011663)4.38189704
16Alkalosis (HP:0001948)4.38098399
17Flattened epiphyses (HP:0003071)4.20110134
18Hyponatremia (HP:0002902)4.15327366
19Neonatal short-limb short stature (HP:0008921)3.80295956
20Abnormal pancreas size (HP:0012094)3.78428687
21Flat capital femoral epiphysis (HP:0003370)3.69820557
22Hypokalemia (HP:0002900)3.39252041
23Dehydration (HP:0001944)3.29471313
24Abnormal spermatogenesis (HP:0008669)3.20526922
25Abnormality of potassium homeostasis (HP:0011042)3.20454791
26Abnormality of sodium homeostasis (HP:0010931)3.14645376
27Gastrointestinal dysmotility (HP:0002579)3.08106202
28Hyperkalemia (HP:0002153)2.96787699
29Abnormality of the distal phalanx of the thumb (HP:0009617)2.94628856
30Abnormality of monocarboxylic acid metabolism (HP:0010996)2.94271816
31Abdominal distention (HP:0003270)2.86435564
32Intrahepatic cholestasis (HP:0001406)2.83574495
33Abnormal tarsal ossification (HP:0008369)2.83156230
34Breech presentation (HP:0001623)2.77634433
35Conjugated hyperbilirubinemia (HP:0002908)2.75666116
36Congenital sensorineural hearing impairment (HP:0008527)2.69969108
37Renal tubular acidosis (HP:0001947)2.69245553
38Adrenal overactivity (HP:0002717)2.68863584
39Late onset (HP:0003584)2.58395396
40Visceral angiomatosis (HP:0100761)2.56681846
41Curly hair (HP:0002212)2.54429163
42Recurrent pneumonia (HP:0006532)2.53989236
43Irregular epiphyses (HP:0010582)2.50183539
44Symphalangism affecting the phalanges of the hand (HP:0009773)2.49815311
45Vertebral hypoplasia (HP:0008417)2.42118945
46Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.42118945
47Hemangiomatosis (HP:0007461)2.36665084
48Palpitations (HP:0001962)2.34318128
49Large earlobe (HP:0009748)2.34272038
50Vertebral clefting (HP:0008428)2.33534402
51Systemic lupus erythematosus (HP:0002725)2.28405818
52Spinal cord compression (HP:0002176)2.28112609
53Hypercalciuria (HP:0002150)2.24425446
54Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.21004136
55Hypoplasia of the uterus (HP:0000013)2.19083265
56Chronic bronchitis (HP:0004469)1.96785350
57Gout (HP:0001997)1.96449704
58Abnormal vertebral ossification (HP:0100569)1.95575757
59Syncope (HP:0001279)1.94700061
60Abnormal foot bone ossification (HP:0010675)1.85500703
61Petechiae (HP:0000967)1.81144742
62Hemorrhage of the eye (HP:0011885)1.80423191
63Hip contracture (HP:0003273)1.80059129
64Short middle phalanx of finger (HP:0005819)1.79890043
65Aplasia/hypoplasia of the femur (HP:0005613)1.79087091
66Abnormality of the middle phalanges of the toes (HP:0010183)1.78908238
67Bronchiectasis (HP:0002110)1.78543212
68Pili torti (HP:0003777)1.78009796
69Abnormal cartilage morphology (HP:0002763)1.77775401
70Renal salt wasting (HP:0000127)1.77346647
71Unilateral renal agenesis (HP:0000122)1.77054522
72Abnormality of the 2nd finger (HP:0004100)1.74520226
73Abnormality of magnesium homeostasis (HP:0004921)1.73735513
74Hyperammonemia (HP:0001987)1.71455279
75Glomerulonephritis (HP:0000099)1.69993197
76Abnormality of glutamine family amino acid metabolism (HP:0010902)1.69766707
77Insulin resistance (HP:0000855)1.69766680
78Dicarboxylic aciduria (HP:0003215)1.67677902
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67677902
80Hoarse voice (HP:0001609)1.67351374
81Cystic hygroma (HP:0000476)1.65047143
82Abnormality of the 1st metacarpal (HP:0010009)1.63784341
83Abnormality of small intestinal villus morphology (HP:0011472)1.63343476
84Villous atrophy (HP:0011473)1.63343476
85Increased density of long bones (HP:0006392)1.62462374
86Abnormality of vitamin B metabolism (HP:0004340)1.61938727
87Pulmonary fibrosis (HP:0002206)1.60972063
88Abnormality of the phalanges of the 2nd finger (HP:0009541)1.60550237
89Insulin-resistant diabetes mellitus (HP:0000831)1.59901457
90Abnormality of carpal bone ossification (HP:0006257)1.58562996
91Abnormality of the vitamin B12 metabolism (HP:0004341)1.58463357
92Hip dysplasia (HP:0001385)1.53613812
93Hyperparathyroidism (HP:0000843)1.50235813
94Alopecia of scalp (HP:0002293)1.49100690
95Renal tubular dysfunction (HP:0000124)1.48673152
96Recurrent lower respiratory tract infections (HP:0002783)1.48078335
97Abnormality of vitamin metabolism (HP:0100508)1.47292033
98Aplasia/hypoplasia of the uterus (HP:0008684)1.47149067
99Biliary tract neoplasm (HP:0100574)1.44135883
100Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.44120253

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKG23.37024242
2PIK3CA3.28471371
3EPHA22.49743992
4STK242.14584059
5MST1R2.13333687
6ACVR1B2.05756442
7LMTK215.0224967
8MAP4K21.65319511
9RIPK11.50649511
10STK38L1.43375776
11STK391.40167779
12MAP3K121.38415214
13OXSR10.99486163
14EPHB20.99091834
15MST40.94027922
16PDK20.88584313
17TNIK0.87366792
18PASK0.86251788
19STK30.83096353
20ROCK10.78685131
21PTK60.69748974
22MET0.69585190
23MAPK110.65389925
24FER0.64090114
25MAPKAPK30.62185277
26MYLK0.61197590
27NLK0.57428932
28WNK40.56544358
29EIF2AK30.53324066
30PRKAA10.50810259
31PAK40.49907993
32GRK10.49874627
33BCR0.49788956
34MAP3K20.49635823
35PRKCQ0.48312718
36MAP3K30.47557267
37PTK20.42974314
38ERBB20.41644588
39ERN10.40704767
40INSRR0.40556750
41FRK0.37890341
42PHKG20.34656494
43PHKG10.34656494
44CAMK2D0.34514082
45PRKAA20.33697942
46HIPK20.33550424
47MAP2K60.32763802
48MAP2K20.30719203
49MAP3K100.28888105
50PRKACG0.28868643
51PRKCI0.28391313
52DAPK10.27980446
53TESK10.25445057
54PRKCE0.24688398
55CASK0.24504547
56DAPK20.24495807
57MELK0.23460970
58DMPK0.22381534
59PRKG10.20686755
60NEK60.20105443
61PDPK10.19883984
62ICK0.18865654
63ABL20.18393816
64SMG10.18366665
65PRKCA0.17960633
66CSNK1A10.17560657
67EPHA40.15843959
68MAPK70.15216520
69IKBKB0.15208076
70CAMKK20.14430746
71PDK10.13892227
72EPHA30.13138711
73TAOK10.13126734
74FGFR30.12592675
75BMPR20.11896680
76ERBB30.10501316
77SRC0.10058825
78LIMK10.09237684
79MAP2K10.09147373
80RIPK40.08895460
81PRKCD0.08318316
82MAPKAPK20.08272786
83VRK20.08210949
84PNCK0.08150480
85PRKCB0.06956214
86YES10.06654387
87MAPKAPK50.06650359
88RPS6KA20.06425994
89FGFR10.05504933
90MATK0.04892955
91EEF2K0.04791764
92TRPM70.04497268
93FGFR20.04124714
94PAK30.03517371
95NUAK10.03438684
96DAPK30.02737331
97ADRBK20.02565016
98EPHB10.02000048
99BRSK20.01550744
100NEK90.01534959

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.49794332
2Sulfur metabolism_Homo sapiens_hsa009205.34755692
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049645.31904583
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006013.13004659
5Mineral absorption_Homo sapiens_hsa049782.84981414
6Caffeine metabolism_Homo sapiens_hsa002322.75057678
7Bile secretion_Homo sapiens_hsa049762.71699593
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.67650153
9Pancreatic secretion_Homo sapiens_hsa049722.54049185
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52514337
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.41056624
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.32660634
13Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.05978703
14Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.91272103
15Retinol metabolism_Homo sapiens_hsa008301.85336283
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82501666
17Steroid hormone biosynthesis_Homo sapiens_hsa001401.80348904
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77275647
19Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61938672
20Butanoate metabolism_Homo sapiens_hsa006501.57068993
21Chemical carcinogenesis_Homo sapiens_hsa052041.54985986
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.53960896
23Fatty acid degradation_Homo sapiens_hsa000711.49768077
24Vibrio cholerae infection_Homo sapiens_hsa051101.45600533
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36593754
26Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.34128846
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.31064224
28Histidine metabolism_Homo sapiens_hsa003401.28522058
29Tight junction_Homo sapiens_hsa045301.22161066
30ABC transporters_Homo sapiens_hsa020101.13333577
31Leukocyte transendothelial migration_Homo sapiens_hsa046701.08645247
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.05663561
33Starch and sucrose metabolism_Homo sapiens_hsa005001.04963109
34Fat digestion and absorption_Homo sapiens_hsa049751.04587631
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98300718
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97491008
37Gastric acid secretion_Homo sapiens_hsa049710.89890461
38Hepatitis C_Homo sapiens_hsa051600.89654653
39Fructose and mannose metabolism_Homo sapiens_hsa000510.89262057
40Tryptophan metabolism_Homo sapiens_hsa003800.88816299
41Arginine biosynthesis_Homo sapiens_hsa002200.83492643
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82445893
43Propanoate metabolism_Homo sapiens_hsa006400.77968152
44Arginine and proline metabolism_Homo sapiens_hsa003300.74367230
45PPAR signaling pathway_Homo sapiens_hsa033200.68766804
46Glutathione metabolism_Homo sapiens_hsa004800.65498402
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.65232127
48Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61316666
49Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61292974
50Glycerolipid metabolism_Homo sapiens_hsa005610.60147638
51Tyrosine metabolism_Homo sapiens_hsa003500.57063231
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55185903
53Sulfur relay system_Homo sapiens_hsa041220.53894744
54Other glycan degradation_Homo sapiens_hsa005110.53045888
55Sphingolipid metabolism_Homo sapiens_hsa006000.52675133
56Thyroid hormone synthesis_Homo sapiens_hsa049180.51697103
57Pertussis_Homo sapiens_hsa051330.49246977
58Circadian rhythm_Homo sapiens_hsa047100.44874576
59Collecting duct acid secretion_Homo sapiens_hsa049660.42109695
60Complement and coagulation cascades_Homo sapiens_hsa046100.40506042
61Galactose metabolism_Homo sapiens_hsa000520.37369904
62Linoleic acid metabolism_Homo sapiens_hsa005910.36726161
63Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.36525128
64Arachidonic acid metabolism_Homo sapiens_hsa005900.35043631
65Fatty acid metabolism_Homo sapiens_hsa012120.34847031
66Ether lipid metabolism_Homo sapiens_hsa005650.34320692
67alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32512924
68Dorso-ventral axis formation_Homo sapiens_hsa043200.32430707
69Protein digestion and absorption_Homo sapiens_hsa049740.31317321
70Peroxisome_Homo sapiens_hsa041460.29091407
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27219458
72Phenylalanine metabolism_Homo sapiens_hsa003600.25670464
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.25388995
74AMPK signaling pathway_Homo sapiens_hsa041520.22931124
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.20638430
76Cysteine and methionine metabolism_Homo sapiens_hsa002700.19888180
77Thyroid cancer_Homo sapiens_hsa052160.19653553
78Renin secretion_Homo sapiens_hsa049240.18728268
79Primary bile acid biosynthesis_Homo sapiens_hsa001200.18077624
80beta-Alanine metabolism_Homo sapiens_hsa004100.18075807
81Metabolic pathways_Homo sapiens_hsa011000.17012553
82Carbon metabolism_Homo sapiens_hsa012000.14972852
83African trypanosomiasis_Homo sapiens_hsa051430.14653746
84Pyruvate metabolism_Homo sapiens_hsa006200.13679994
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.13110012
86Adherens junction_Homo sapiens_hsa045200.12564082
87Rheumatoid arthritis_Homo sapiens_hsa053230.12048737
88Salivary secretion_Homo sapiens_hsa049700.11871548
89Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.11665463
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.11519412
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10452968
92Fatty acid elongation_Homo sapiens_hsa000620.10255315
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.07013584
94TGF-beta signaling pathway_Homo sapiens_hsa043500.06161166
95Cardiac muscle contraction_Homo sapiens_hsa042600.05765961
96Choline metabolism in cancer_Homo sapiens_hsa052310.05367532
97Renin-angiotensin system_Homo sapiens_hsa046140.05004884
98Salmonella infection_Homo sapiens_hsa051320.04975443
99Shigellosis_Homo sapiens_hsa051310.04382871
100Staphylococcus aureus infection_Homo sapiens_hsa051500.03479339

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »