CEACAM3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.62474372
2negative regulation of cell killing (GO:0031342)6.55935420
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.55935420
4positive regulation by symbiont of host defense response (GO:0052509)6.25200276
5modulation by symbiont of host defense response (GO:0052031)6.25200276
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.25200276
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.25200276
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.25200276
9modulation by symbiont of host immune response (GO:0052553)6.25200276
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.78021368
11negative regulation of myotube differentiation (GO:0010832)5.73399568
12positive regulation of gamma-delta T cell activation (GO:0046645)5.61025091
13detection of other organism (GO:0098543)5.53696964
14antigen processing and presentation of endogenous antigen (GO:0019883)5.50977032
15detection of bacterium (GO:0016045)5.28292466
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.16276796
17macrophage activation involved in immune response (GO:0002281)5.14796527
18leukocyte migration involved in inflammatory response (GO:0002523)5.06517860
19regulation of B cell receptor signaling pathway (GO:0050855)4.90095733
20presynaptic membrane assembly (GO:0097105)4.89988689
21detection of molecule of bacterial origin (GO:0032490)4.88769926
22leukocyte aggregation (GO:0070486)4.87518650
23detection of external biotic stimulus (GO:0098581)4.87168276
24neutrophil activation (GO:0042119)4.72499573
25cellular extravasation (GO:0045123)4.69829596
26response to interleukin-15 (GO:0070672)4.53560193
27positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.49527388
28negative regulation of lymphocyte mediated immunity (GO:0002707)4.46621760
29negative regulation of interleukin-12 production (GO:0032695)4.44671783
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.42655870
31response to host immune response (GO:0052572)4.42655870
32endothelium development (GO:0003158)4.41568714
33postsynaptic membrane organization (GO:0001941)4.37910721
34regulation of interferon-beta biosynthetic process (GO:0045357)4.36736730
35granulocyte activation (GO:0036230)4.27664626
36facial nerve structural organization (GO:0021612)4.27270957
37detection of biotic stimulus (GO:0009595)4.22994954
38positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.22097344
39cellular response to interleukin-15 (GO:0071350)4.20418281
40regulation of pigment cell differentiation (GO:0050932)4.14690140
41microglial cell activation (GO:0001774)4.12155754
42presynaptic membrane organization (GO:0097090)4.07931250
43neutrophil mediated immunity (GO:0002446)4.07564510
44regulation of gamma-delta T cell activation (GO:0046643)4.06588075
45response to host (GO:0075136)4.05606319
46response to host defenses (GO:0052200)4.05606319
47response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.05606319
48negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.00860972
49production of molecular mediator involved in inflammatory response (GO:0002532)3.90890395
50negative regulation of leukocyte mediated immunity (GO:0002704)3.89813833
51macrophage activation (GO:0042116)3.86529279
52immunoglobulin mediated immune response (GO:0016064)3.86307885
53respiratory chain complex IV assembly (GO:0008535)3.82944319
54myeloid cell activation involved in immune response (GO:0002275)3.80412693
55regulation of mast cell degranulation (GO:0043304)3.76051403
56negative regulation of smooth muscle cell differentiation (GO:0051151)3.73050739
57cranial nerve morphogenesis (GO:0021602)3.71135923
58protein heterotetramerization (GO:0051290)3.66925738
59superoxide anion generation (GO:0042554)3.59136469
60cellular response to type I interferon (GO:0071357)3.58666872
61type I interferon signaling pathway (GO:0060337)3.58666872
62regulation of gamma-delta T cell differentiation (GO:0045586)3.56405083
63response to type I interferon (GO:0034340)3.56016926
64negative regulation of T cell mediated immunity (GO:0002710)3.53983915
65regulation of myeloid leukocyte mediated immunity (GO:0002886)3.49961630
66regulation of mast cell activation involved in immune response (GO:0033006)3.46815515
67myeloid leukocyte mediated immunity (GO:0002444)3.46281384
68cytochrome complex assembly (GO:0017004)3.45839519
69lymphoid progenitor cell differentiation (GO:0002320)3.44854661
70positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.44804853
71negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.44038609
72leukocyte degranulation (GO:0043299)3.40106446
73positive regulation of mast cell activation (GO:0033005)3.39717424
74negative regulation of phagocytosis (GO:0050765)3.39585581
75short-term memory (GO:0007614)3.39222433
76antigen processing and presentation via MHC class Ib (GO:0002475)3.38515119
77response to folic acid (GO:0051593)3.33192537
78germinal center formation (GO:0002467)3.31712285
79regulation of leukocyte degranulation (GO:0043300)3.30269265
80DNA ligation (GO:0006266)3.29678901
81regulation of T cell tolerance induction (GO:0002664)3.29206110
82B cell receptor signaling pathway (GO:0050853)3.29038484
83regulation of mast cell activation (GO:0033003)3.27978524
84cranial nerve structural organization (GO:0021604)3.27864179
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.27503466
86negative regulation of T-helper cell differentiation (GO:0045623)3.27503466
87negative regulation of leukocyte chemotaxis (GO:0002689)3.27489646
88DNA deamination (GO:0045006)3.24586602
89dendritic cell migration (GO:0036336)3.23905009
90regulation of tolerance induction (GO:0002643)3.23699011
91regulation of T-helper 2 cell differentiation (GO:0045628)3.20771940
92defense response to protozoan (GO:0042832)3.19196142
93regulation of B cell differentiation (GO:0045577)3.18572693
94omega-hydroxylase P450 pathway (GO:0097267)3.15663702
95positive regulation of T cell mediated cytotoxicity (GO:0001916)3.14240287
96amino sugar catabolic process (GO:0046348)3.14088264
97regulation of T cell mediated cytotoxicity (GO:0001914)3.11539871
98negative regulation of interleukin-6 production (GO:0032715)3.10569410
99B cell mediated immunity (GO:0019724)3.08853097
100response to muramyl dipeptide (GO:0032495)3.08748605
101neutrophil chemotaxis (GO:0030593)3.05532715
102lipopolysaccharide-mediated signaling pathway (GO:0031663)3.05284478
103regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.03948966
104interferon-gamma-mediated signaling pathway (GO:0060333)3.03140717
105developmental pigmentation (GO:0048066)3.02415176
106proteasome assembly (GO:0043248)3.02192595
107regulation of natural killer cell mediated immunity (GO:0002715)3.01226694
108regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.01226694
109regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.99377492
110negative regulation of type 2 immune response (GO:0002829)2.98983344
111negative regulation of alpha-beta T cell activation (GO:0046636)2.98432988
112regulation of regulated secretory pathway (GO:1903305)2.98031555
113neutrophil migration (GO:1990266)2.97782249
114ribosomal small subunit biogenesis (GO:0042274)2.97591165
115myeloid leukocyte activation (GO:0002274)2.95864691
116mesonephros development (GO:0001823)2.94432269
117positive regulation of B cell differentiation (GO:0045579)2.93629351
118mesenchymal cell differentiation involved in kidney development (GO:0072161)2.93284513
119mesenchymal cell differentiation involved in renal system development (GO:2001012)2.93284513
120positive regulation of interferon-alpha production (GO:0032727)2.92298774
121negative regulation of innate immune response (GO:0045824)2.91291589
122negative regulation of cytokine production involved in immune response (GO:0002719)2.91161218
123positive regulation of mast cell degranulation (GO:0043306)2.90865634
124positive regulation of mast cell activation involved in immune response (GO:0033008)2.90865634
125androgen biosynthetic process (GO:0006702)2.87704248
126negative regulation of transcription by competitive promoter binding (GO:0010944)2.85102766
127transcription elongation from RNA polymerase III promoter (GO:0006385)2.84592047
128termination of RNA polymerase III transcription (GO:0006386)2.84592047
129mannosylation (GO:0097502)2.84254845
130neuronal action potential propagation (GO:0019227)2.82916425
131negative regulation of execution phase of apoptosis (GO:1900118)2.80772743
132melanin metabolic process (GO:0006582)2.78496446
133keratinocyte development (GO:0003334)2.76854752
134negative regulation of metanephros development (GO:0072217)2.74484262
135negative regulation of striated muscle cell differentiation (GO:0051154)2.72431696
136GPI anchor biosynthetic process (GO:0006506)2.71696045
137sphingoid metabolic process (GO:0046519)2.70161108
138viral transcription (GO:0019083)2.69462619
139negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.69071906
140mature B cell differentiation (GO:0002335)2.68335542
141regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.66753379
142pattern specification involved in kidney development (GO:0061004)2.65158495
143N-acetylneuraminate metabolic process (GO:0006054)2.64313981
144cotranslational protein targeting to membrane (GO:0006613)2.63466257
145regulation of timing of cell differentiation (GO:0048505)2.63199431
146negative regulation of muscle cell differentiation (GO:0051148)2.63082313
147SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.62175165
148protein targeting to ER (GO:0045047)2.59722339
149sympathetic nervous system development (GO:0048485)2.59535256
150nucleoside diphosphate catabolic process (GO:0009134)2.56466473
151signal peptide processing (GO:0006465)2.55619517
152positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.54670725
153generation of neurons (GO:0048699)2.54249823
154righting reflex (GO:0060013)2.54103317
155viral genome replication (GO:0019079)2.51610976
156response to increased oxygen levels (GO:0036296)2.50963948
157response to hyperoxia (GO:0055093)2.50963948
158parturition (GO:0007567)2.50478852
159glucosamine-containing compound catabolic process (GO:1901072)2.49399264
160translational termination (GO:0006415)2.48653203
161protein localization to endoplasmic reticulum (GO:0070972)2.48056784
162positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.48036595
163response to peptidoglycan (GO:0032494)2.47808284
164negative regulation of anoikis (GO:2000811)2.47288098
165protein complex biogenesis (GO:0070271)2.47136579
166regulation of male gonad development (GO:2000018)2.46572353
167establishment of protein localization to endoplasmic reticulum (GO:0072599)2.45248313
168Rap protein signal transduction (GO:0032486)2.44497549
169C-terminal protein lipidation (GO:0006501)2.44165550
170regulation of interleukin-8 secretion (GO:2000482)2.43892504
171mature B cell differentiation involved in immune response (GO:0002313)2.41913768
172positive regulation of uterine smooth muscle contraction (GO:0070474)2.41509048
173cerebral cortex radially oriented cell migration (GO:0021799)2.37702523
174positive regulation of cellular amine metabolic process (GO:0033240)2.36857449
175regulation of non-canonical Wnt signaling pathway (GO:2000050)2.36728076
176negative regulation of homotypic cell-cell adhesion (GO:0034111)2.35412151
177dendritic cell chemotaxis (GO:0002407)2.34784519
178GTP biosynthetic process (GO:0006183)2.34717878
179neuron cell-cell adhesion (GO:0007158)2.34622553
180regulation of development, heterochronic (GO:0040034)2.33065262
181nephron epithelium development (GO:0072009)2.31221595
182regulation of G0 to G1 transition (GO:0070316)2.29515537
183cell differentiation involved in metanephros development (GO:0072202)2.28968481
184platelet dense granule organization (GO:0060155)2.27298227
185mast cell activation (GO:0045576)2.26910254
186neutrophil activation involved in immune response (GO:0002283)2.26481584
187DNA integration (GO:0015074)2.26140085
188negative regulation of gluconeogenesis (GO:0045721)2.25438675
189GPI anchor metabolic process (GO:0006505)2.23734977
190negative regulation of norepinephrine secretion (GO:0010700)2.23419666
191purine deoxyribonucleotide catabolic process (GO:0009155)2.22377317
192membrane invagination (GO:0010324)2.21165024
193positive regulation of protein kinase C signaling (GO:0090037)2.20948224
194regulation of smooth muscle cell differentiation (GO:0051150)2.20156997
195GMP metabolic process (GO:0046037)2.19680452
196respiratory burst (GO:0045730)2.19541027

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.32765751
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.95510091
3MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.83299566
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.80230058
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.76982944
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.46786626
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.21275218
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.19188123
9IRF8_27001747_Chip-Seq_BMDM_Mouse3.15956033
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87719194
11SPI1_23547873_ChIP-Seq_NB4_Human2.86092316
12GBX2_23144817_ChIP-Seq_PC3_Human2.84310585
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76517583
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75496760
15VDR_21846776_ChIP-Seq_THP-1_Human2.74093942
16SPI1_23127762_ChIP-Seq_K562_Human2.71887134
17VDR_24763502_ChIP-Seq_THP-1_Human2.69434461
18RUNX_20019798_ChIP-Seq_JUKART_Human2.66943253
19RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.61445355
20IGF1R_20145208_ChIP-Seq_DFB_Human2.60864571
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.50951964
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.50277509
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.48755250
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.46704749
25TAF15_26573619_Chip-Seq_HEK293_Human2.44537894
26SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42602831
27MAF_26560356_Chip-Seq_TH1_Human2.40947241
28PCGF2_27294783_Chip-Seq_ESCs_Mouse2.38574718
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.31152060
30CBX2_27304074_Chip-Seq_ESCs_Mouse2.28194737
31MYB_26560356_Chip-Seq_TH2_Human2.27997999
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.25891091
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.25786798
34BP1_19119308_ChIP-ChIP_Hs578T_Human2.25388363
35FLI1_27457419_Chip-Seq_LIVER_Mouse2.23518115
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20721282
37UTX_26944678_Chip-Seq_JUKART_Human2.20637724
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.15081370
39STAT4_19710469_ChIP-ChIP_TH1__Mouse2.14504161
40EZH2_27304074_Chip-Seq_ESCs_Mouse2.13958828
41BRD4_27068464_Chip-Seq_AML-cells_Mouse2.12864992
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.11289052
43CDX2_19796622_ChIP-Seq_MESCs_Mouse2.06607154
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.99904302
45MYB_26560356_Chip-Seq_TH1_Human1.98892184
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.97373387
47MYC_22102868_ChIP-Seq_BL_Human1.97302672
48TCF7_22412390_ChIP-Seq_EML_Mouse1.96192358
49KDM2B_26808549_Chip-Seq_SUP-B15_Human1.95864661
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92727289
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.92315362
52RNF2_27304074_Chip-Seq_NSC_Mouse1.88206625
53SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86243756
54EED_16625203_ChIP-ChIP_MESCs_Mouse1.82730082
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.80933639
56MAF_26560356_Chip-Seq_TH2_Human1.79110661
57SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.77074851
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.75736925
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75643298
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.73267528
61KDM2B_26808549_Chip-Seq_DND41_Human1.72550793
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.71428369
63VDR_24787735_ChIP-Seq_THP-1_Human1.70989146
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70155924
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.70070242
66GATA3_27048872_Chip-Seq_THYMUS_Human1.69328550
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.69214334
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.68167991
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.68076699
70POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66534320
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.66258230
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.66258230
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.63186549
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62576202
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.60376596
76THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58740868
77SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58430215
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57934881
79STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55775175
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55422429
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53324783
82NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52101620
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51848692
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50996791
85P53_22387025_ChIP-Seq_ESCs_Mouse1.50289974
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50181526
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.48931521
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.48622593
89ER_23166858_ChIP-Seq_MCF-7_Human1.45341370
90NMYC_18555785_Chip-Seq_ESCs_Mouse1.45165799
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45152248
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44567628
93VDR_22108803_ChIP-Seq_LS180_Human1.42624308
94EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.42534735
95ELF1_17652178_ChIP-ChIP_JURKAT_Human1.42516348
96P300_18555785_Chip-Seq_ESCs_Mouse1.41762493
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.41383091
98STAT3_18555785_Chip-Seq_ESCs_Mouse1.41241001
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.39480156
100IRF1_19129219_ChIP-ChIP_H3396_Human1.39326986
101SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39081058
102EZH2_27294783_Chip-Seq_ESCs_Mouse1.39063837
103RUNX1_27457419_Chip-Seq_LIVER_Mouse1.39052382
104GATA2_22383799_ChIP-Seq_G1ME_Mouse1.39045163
105IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38485141
106PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37902694
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.37596169
108GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.34076939
109P300_19829295_ChIP-Seq_ESCs_Human1.33341007
110GATA3_26560356_Chip-Seq_TH2_Human1.33015131
111CMYC_18555785_Chip-Seq_ESCs_Mouse1.32818758
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.30802396
113SUZ12_27294783_Chip-Seq_ESCs_Mouse1.30456782
114IRF8_21731497_ChIP-ChIP_J774_Mouse1.28615381
115CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27881020
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27032579
117PU_27001747_Chip-Seq_BMDM_Mouse1.26468358
118SOX2_18555785_Chip-Seq_ESCs_Mouse1.25752536
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25741489
120NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.25609545
121GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25068556
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24152868
123GATA1_22025678_ChIP-Seq_K562_Human1.23859964
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23137478
125SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22919893
126GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22338671
127KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.21690901
128LXR_22292898_ChIP-Seq_THP-1_Human1.21456301
129RNF2_27304074_Chip-Seq_ESCs_Mouse1.20966735
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.19766890
131MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19621261
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19395041
133ZFX_18555785_Chip-Seq_ESCs_Mouse1.19024835
134CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.18828070
135GATA1_19941826_ChIP-Seq_K562_Human1.17893965
136KDM2B_26808549_Chip-Seq_JURKAT_Human1.16010650
137OCT4_18555785_Chip-Seq_ESCs_Mouse1.15946731
138VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.15837538
139KLF4_18555785_Chip-Seq_ESCs_Mouse1.15756252
140SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15619311
141ESRRB_18555785_Chip-Seq_ESCs_Mouse1.15340573
142CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14872909
143IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14246422
144PU1_27457419_Chip-Seq_LIVER_Mouse1.13888727
145BCL6_27268052_Chip-Seq_Bcells_Human1.13594349
146KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.12826863
147KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.12826863
148KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.12826863
149CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12094195
150CTCF_18555785_Chip-Seq_ESCs_Mouse1.11965567
151GATA2_21666600_ChIP-Seq_HMVEC_Human1.11128173
152SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11100686
153NOTCH1_21737748_ChIP-Seq_TLL_Human1.10841336
154CRX_20693478_ChIP-Seq_RETINA_Mouse1.10829578
155PU.1_20513432_ChIP-Seq_Bcells_Mouse1.10706300
156MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10494812
157POU5F1_16153702_ChIP-ChIP_HESCs_Human1.08500670
158CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08365069
159SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.08071475
160SCL_19346495_ChIP-Seq_HPC-7_Human1.06622410
161SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05799470
162BCOR_27268052_Chip-Seq_Bcells_Human1.05385997
163E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04970786
164KAP1_22055183_ChIP-Seq_ESCs_Mouse1.04861759
165AR_21572438_ChIP-Seq_LNCaP_Human1.04374665
166SMAD3_21741376_ChIP-Seq_EPCs_Human1.03923173
167UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01578172
168ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.01462345
169CDX2_20551321_ChIP-Seq_CACO-2_Human0.99330781
170PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99291647
171TP53_18474530_ChIP-ChIP_U2OS_Human0.99161595
172RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96426801
173TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96194785
174KDM2B_26808549_Chip-Seq_REH_Human0.96006743
175GATA2_19941826_ChIP-Seq_K562_Human0.95527117
176FUS_26573619_Chip-Seq_HEK293_Human0.94272163
177EWS_26573619_Chip-Seq_HEK293_Human0.92796655
178PIAS1_25552417_ChIP-Seq_VCAP_Human0.92458118
179CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91526910
180RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91449208
181IRF8_22096565_ChIP-ChIP_GC-B_Human0.89745287
182CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89709180
183SPI1_20517297_ChIP-Seq_HL60_Human0.88395673
184NCOR1_26117541_ChIP-Seq_K562_Human0.86502010
185NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83097417
186STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83036842
187SA1_27219007_Chip-Seq_ERYTHROID_Human0.77180893
188SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75909020

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.87566951
2MP0003136_yellow_coat_color5.05317128
3MP0001188_hyperpigmentation4.61123360
4MP0003724_increased_susceptibility_to3.89974131
5MP0005409_darkened_coat_color3.38023190
6MP0004381_abnormal_hair_follicle3.29506727
7MP0006292_abnormal_olfactory_placode3.16263545
8MP0000015_abnormal_ear_pigmentation3.12321886
9MP0005174_abnormal_tail_pigmentation2.87170221
10MP0005387_immune_system_phenotype2.81004333
11MP0001790_abnormal_immune_system2.81004333
12MP0003880_abnormal_central_pattern2.80682033
13MP0000685_abnormal_immune_system2.75892629
14MP0006082_CNS_inflammation2.60192215
15MP0003191_abnormal_cellular_cholesterol2.52546256
16MP0000372_irregular_coat_pigmentation2.44566861
17MP0003300_gastrointestinal_ulcer2.38341557
18MP0001986_abnormal_taste_sensitivity2.33081313
19MP0001533_abnormal_skeleton_physiology2.29443598
20MP0005171_absent_coat_pigmentation2.19840828
21MP0002405_respiratory_system_inflammati2.08442045
22MP0003303_peritoneal_inflammation2.04973041
23MP0005464_abnormal_platelet_physiology2.02143926
24MP0002398_abnormal_bone_marrow1.91481682
25MP0002102_abnormal_ear_morphology1.88434243
26MP0000716_abnormal_immune_system1.88161755
27MP0006276_abnormal_autonomic_nervous1.81829943
28MP0010155_abnormal_intestine_physiology1.79179216
29MP0001845_abnormal_inflammatory_respons1.77476107
30MP0002396_abnormal_hematopoietic_system1.73775654
31MP0009278_abnormal_bone_marrow1.71659673
32MP0002876_abnormal_thyroid_physiology1.71206725
33MP0003866_abnormal_defecation1.71057477
34MP0002095_abnormal_skin_pigmentation1.68169599
35MP0003183_abnormal_peptide_metabolism1.66386069
36MP0008260_abnormal_autophagy1.64486444
37MP0005075_abnormal_melanosome_morpholog1.60797400
38MP0004947_skin_inflammation1.58442232
39MP0003172_abnormal_lysosome_physiology1.58405422
40MP0009764_decreased_sensitivity_to1.57554419
41MP0002722_abnormal_immune_system1.57389403
42MP0000689_abnormal_spleen_morphology1.55237045
43MP0002148_abnormal_hypersensitivity_rea1.55131733
44MP0005451_abnormal_body_composition1.52401099
45MP0002429_abnormal_blood_cell1.48361754
46MP0008469_abnormal_protein_level1.48175410
47MP0009333_abnormal_splenocyte_physiolog1.47592611
48MP0009785_altered_susceptibility_to1.46354298
49MP0004883_abnormal_blood_vessel1.44039100
50MP0002277_abnormal_respiratory_mucosa1.43711073
51MP0004742_abnormal_vestibular_system1.42264064
52MP0000703_abnormal_thymus_morphology1.41459126
53MP0002009_preneoplasia1.36846570
54MP0002177_abnormal_outer_ear1.36705240
55MP0000681_abnormal_thyroid_gland1.32862653
56MP0003075_altered_response_to1.32535886
57MP0000858_altered_metastatic_potential1.31519903
58MP0002638_abnormal_pupillary_reflex1.31406149
59MP0005671_abnormal_response_to1.31251118
60MP0005310_abnormal_salivary_gland1.30360928
61MP0004510_myositis1.29448945
62MP0001851_eye_inflammation1.27319709
63MP0001661_extended_life_span1.24507760
64MP0000049_abnormal_middle_ear1.21251056
65MP0002163_abnormal_gland_morphology1.20970219
66MP0001545_abnormal_hematopoietic_system1.20618080
67MP0005397_hematopoietic_system_phenotyp1.20618080
68MP0000566_synostosis1.18199045
69MP0001835_abnormal_antigen_presentation1.16763424
70MP0002998_abnormal_bone_remodeling1.12998549
71MP0005000_abnormal_immune_tolerance1.11952741
72MP0009697_abnormal_copulation1.08776984
73MP0003941_abnormal_skin_development1.08306706
74MP0000465_gastrointestinal_hemorrhage1.06150517
75MP0002938_white_spotting1.04371175
76MP0004142_abnormal_muscle_tone1.02862881
77MP0003938_abnormal_ear_development1.02286218
78MP0000613_abnormal_salivary_gland1.01976396
79MP0003690_abnormal_glial_cell1.00381016
80MP0000026_abnormal_inner_ear0.99521165
81MP0001968_abnormal_touch/_nociception0.98949409
82MP0003879_abnormal_hair_cell0.97737648
83MP0002419_abnormal_innate_immunity0.97723073
84MP0001905_abnormal_dopamine_level0.97707349
85MP0005645_abnormal_hypothalamus_physiol0.96221203
86MP0001663_abnormal_digestive_system0.95383640
87MP0005166_decreased_susceptibility_to0.95127210
88MP0005248_abnormal_Harderian_gland0.94904697
89MP0005595_abnormal_vascular_smooth0.94440522
90MP0003045_fibrosis0.94312500
91MP0002249_abnormal_larynx_morphology0.93411205
92MP0005390_skeleton_phenotype0.93186745
93MP0005025_abnormal_response_to0.92578506
94MP0005379_endocrine/exocrine_gland_phen0.92201470
95MP0005377_hearing/vestibular/ear_phenot0.92181169
96MP0003878_abnormal_ear_physiology0.92181169
97MP0001919_abnormal_reproductive_system0.89962679
98MP0001346_abnormal_lacrimal_gland0.87903796
99MP0003011_delayed_dark_adaptation0.87664911
100MP0000490_abnormal_crypts_of0.87576846
101MP0002751_abnormal_autonomic_nervous0.87518938
102MP0003828_pulmonary_edema0.87117555
103MP0003763_abnormal_thymus_physiology0.86729300
104MP0008004_abnormal_stomach_pH0.86688675
105MP0003448_altered_tumor_morphology0.86305024
106MP0009763_increased_sensitivity_to0.85413880
107MP0000631_abnormal_neuroendocrine_gland0.85214880
108MP0010386_abnormal_urinary_bladder0.82995863
109MP0002132_abnormal_respiratory_system0.82574409
110MP0003436_decreased_susceptibility_to0.81848757
111MP0002166_altered_tumor_susceptibility0.81434577
112MP0002723_abnormal_immune_serum0.80839866
113MP0001486_abnormal_startle_reflex0.79763768
114MP0004272_abnormal_basement_membrane0.79654906
115MP0001502_abnormal_circadian_rhythm0.79539053
116MP0003806_abnormal_nucleotide_metabolis0.79033456
117MP0001963_abnormal_hearing_physiology0.78529327
118MP0003786_premature_aging0.78495595
119MP0002067_abnormal_sensory_capabilities0.78328193
120MP0005084_abnormal_gallbladder_morpholo0.78211264
121MP0002557_abnormal_social/conspecific_i0.77762767
122MP0009250_abnormal_appendicular_skeleto0.77125012
123MP0003656_abnormal_erythrocyte_physiolo0.76900302
124MP0002933_joint_inflammation0.76471753
125MP0002420_abnormal_adaptive_immunity0.75937084
126MP0001819_abnormal_immune_cell0.75296327
127MP0002452_abnormal_antigen_presenting0.74305869
128MP0001542_abnormal_bone_strength0.73586163
129MP0002272_abnormal_nervous_system0.73341655
130MP0009765_abnormal_xenobiotic_induced0.73063791
131MP0003385_abnormal_body_wall0.73062518
132MP0003315_abnormal_perineum_morphology0.72798686
133MP0003221_abnormal_cardiomyocyte_apopto0.72233195
134MP0001873_stomach_inflammation0.71972631
135MP0005083_abnormal_biliary_tract0.71226164
136MP0005381_digestive/alimentary_phenotyp0.70617069
137MP0002160_abnormal_reproductive_system0.69741035
138MP0004858_abnormal_nervous_system0.69698303
139MP0004808_abnormal_hematopoietic_stem0.67140300
140MP0004147_increased_porphyrin_level0.66994729
141MP0005164_abnormal_response_to0.66347491
142MP0008874_decreased_physiological_sensi0.65596674
143MP0004130_abnormal_muscle_cell0.65550963
144MP0002138_abnormal_hepatobiliary_system0.65427933
145MP0001485_abnormal_pinna_reflex0.64930620
146MP0000920_abnormal_myelination0.63902998
147MP0005551_abnormal_eye_electrophysiolog0.62844049
148MP0003795_abnormal_bone_structure0.62821433
149MP0000604_amyloidosis0.62716684
150MP0002736_abnormal_nociception_after0.62627693
151MP0001800_abnormal_humoral_immune0.62552075
152MP0009745_abnormal_behavioral_response0.62533888
153MP0001186_pigmentation_phenotype0.61485416
154MP0002928_abnormal_bile_duct0.60940523
155MP0005058_abnormal_lysosome_morphology0.60769305
156MP0001664_abnormal_digestion0.60733811
157MP0003646_muscle_fatigue0.59219960
158MP0002332_abnormal_exercise_endurance0.59213588
159MP0005165_increased_susceptibility_to0.59182416
160MP0008995_early_reproductive_senescence0.59154491
161MP0005319_abnormal_enzyme/_coenzyme0.59076277
162MP0000249_abnormal_blood_vessel0.58249234
163MP0002133_abnormal_respiratory_system0.55659772
164MP0005388_respiratory_system_phenotype0.55659772
165MP0000343_altered_response_to0.55361785
166MP0001853_heart_inflammation0.55244614
167MP0001958_emphysema0.51781796
168MP0002653_abnormal_ependyma_morphology0.46403044

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.21835631
2Myositis (HP:0100614)6.35553285
3Orchitis (HP:0100796)6.07663780
4Abnormality of macrophages (HP:0004311)5.69378590
5Optic neuritis (HP:0100653)5.63892480
6Retrobulbar optic neuritis (HP:0100654)5.63892480
7Recurrent gram-negative bacterial infections (HP:0005420)5.39065450
8Reduced antithrombin III activity (HP:0001976)5.25893753
9Hypochromic microcytic anemia (HP:0004840)5.10158914
10Elevated erythrocyte sedimentation rate (HP:0003565)4.78799959
11Type I transferrin isoform profile (HP:0003642)4.71932763
12Gastrointestinal infarctions (HP:0005244)4.59849882
13Recurrent fungal infections (HP:0002841)4.24295308
14Mediastinal lymphadenopathy (HP:0100721)4.23452455
15Abnormal delayed hypersensitivity skin test (HP:0002963)4.15880845
16Keratoconjunctivitis sicca (HP:0001097)4.12519812
17Hypochromic anemia (HP:0001931)4.05032884
18Encephalitis (HP:0002383)3.89997388
19Keratoconjunctivitis (HP:0001096)3.82425555
20Spontaneous hematomas (HP:0007420)3.80736914
21Increased IgE level (HP:0003212)3.79627674
22Gingivitis (HP:0000230)3.78410976
23Urticaria (HP:0001025)3.76305314
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.64488101
25Vasculitis (HP:0002633)3.51732009
26Episodic fever (HP:0001954)3.45261292
27Chest pain (HP:0100749)3.36304911
28Peritonitis (HP:0002586)3.34886259
29Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.28317917
30Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.26722539
31Abnormal protein N-linked glycosylation (HP:0012347)3.26722539
32Abnormal protein glycosylation (HP:0012346)3.26722539
33Abnormal glycosylation (HP:0012345)3.26722539
34Cellulitis (HP:0100658)3.25590154
35Renal Fanconi syndrome (HP:0001994)3.22124792
36Obstructive lung disease (HP:0006536)3.20156113
37Chronic obstructive pulmonary disease (HP:0006510)3.20156113
383-Methylglutaconic aciduria (HP:0003535)3.19129201
39Absent rod-and cone-mediated responses on ERG (HP:0007688)3.17181969
40Hypothermia (HP:0002045)3.11977408
41Increased hepatocellular lipid droplets (HP:0006565)3.09011820
42Hemoptysis (HP:0002105)3.08388568
43Gingival bleeding (HP:0000225)3.04292367
44Anorexia (HP:0002039)3.03942190
45T lymphocytopenia (HP:0005403)2.99410411
46Exertional dyspnea (HP:0002875)2.95254912
47Pulmonary infiltrates (HP:0002113)2.93565679
48Abnormality of T cell number (HP:0011839)2.93119719
49Arterial thrombosis (HP:0004420)2.89866895
50Aplasia/Hypoplasia of the sacrum (HP:0008517)2.82761908
51Leukocytosis (HP:0001974)2.81026965
52Patchy hypopigmentation of hair (HP:0011365)2.79503354
53Nonprogressive disorder (HP:0003680)2.79276626
54Pulmonary embolism (HP:0002204)2.79180553
55Stomatitis (HP:0010280)2.74135132
56Epistaxis (HP:0000421)2.73206205
57Septo-optic dysplasia (HP:0100842)2.69427944
58Inflammation of the large intestine (HP:0002037)2.65385177
59Increased IgM level (HP:0003496)2.65107203
60Amyloidosis (HP:0011034)2.64315045
61Osteomyelitis (HP:0002754)2.59308580
62Abnormality of T cells (HP:0002843)2.59272649
63Pustule (HP:0200039)2.59127191
64White forelock (HP:0002211)2.56292193
65Gastrointestinal inflammation (HP:0004386)2.55686921
66Abnormal sex determination (HP:0012244)2.54983318
67Sex reversal (HP:0012245)2.54983318
68Abnormality of dental color (HP:0011073)2.52957961
69Granulocytopenia (HP:0001913)2.49448913
70Microvesicular hepatic steatosis (HP:0001414)2.48217734
71Abnormality of the axillary hair (HP:0100134)2.48001597
72Abnormality of secondary sexual hair (HP:0009888)2.48001597
73Congenital sensorineural hearing impairment (HP:0008527)2.47551885
74Sepsis (HP:0100806)2.47306650
75Abnormality of renal resorption (HP:0011038)2.46460497
76Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.46239219
77Gangrene (HP:0100758)2.46041155
78Abnormality of the heme biosynthetic pathway (HP:0010472)2.44027788
79Abnormality of the pleura (HP:0002103)2.43675776
80Recurrent viral infections (HP:0004429)2.42270974
81Parakeratosis (HP:0001036)2.40524368
82Lipid accumulation in hepatocytes (HP:0006561)2.38918710
83Abnormality of the peritoneum (HP:0002585)2.38632114
84Reticulocytopenia (HP:0001896)2.36412666
85Thyroid-stimulating hormone excess (HP:0002925)2.35562522
86Severe visual impairment (HP:0001141)2.35210717
87Optic nerve hypoplasia (HP:0000609)2.33622489
88Attenuation of retinal blood vessels (HP:0007843)2.32143173
89Panhypogammaglobulinemia (HP:0003139)2.31737179
90Abnormality of the septum pellucidum (HP:0007375)2.31039786
91Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.30681137
92Lymphopenia (HP:0001888)2.27849384
93Absent septum pellucidum (HP:0001331)2.27065297
94Dry hair (HP:0011359)2.25272891
95Hypergammaglobulinemia (HP:0010702)2.23425819
96Abnormality of the endocardium (HP:0004306)2.22477294
97Abnormality of T cell physiology (HP:0011840)2.22277341
98Abnormality of the pericardium (HP:0001697)2.20440072
99Recurrent bacterial skin infections (HP:0005406)2.19846018
100Toxemia of pregnancy (HP:0100603)2.19722254
101Split foot (HP:0001839)2.18279838
102Abnormal platelet volume (HP:0011876)2.15906427
103Focal motor seizures (HP:0011153)2.15834260
104Short tibia (HP:0005736)2.15752655
105Abnormality of cells of the lymphoid lineage (HP:0012140)2.15698562
106Premature loss of primary teeth (HP:0006323)2.14983027
107Glomerulopathy (HP:0100820)2.14670091
108Abnormality of magnesium homeostasis (HP:0004921)2.14610954
109Recurrent abscess formation (HP:0002722)2.14309739
110Hepatosplenomegaly (HP:0001433)2.13028947
111Acne (HP:0001061)2.12912168
112Dynein arm defect of respiratory motile cilia (HP:0012255)2.12359820
113Absent/shortened dynein arms (HP:0200106)2.12359820
114Keratitis (HP:0000491)2.10066849
115Skin ulcer (HP:0200042)2.09146320
116Aplasia/hypoplasia of the uterus (HP:0008684)2.08700131
117Mitochondrial inheritance (HP:0001427)2.06802192
118Purpura (HP:0000979)2.06270784
119Eosinophilia (HP:0001880)2.05034470
120Slow saccadic eye movements (HP:0000514)2.04014754
121Meningitis (HP:0001287)2.03817499
122Polycythemia (HP:0001901)2.03777625
123Microcytic anemia (HP:0001935)2.03437927
124Aplasia/Hypoplasia of the tibia (HP:0005772)2.02932718
125Abnormal rod and cone electroretinograms (HP:0008323)2.01589119
126Acute hepatic failure (HP:0006554)2.01581549
127Vertigo (HP:0002321)2.00352403
128Hepatocellular necrosis (HP:0001404)1.97945212
129Aplasia/Hypoplasia of the fovea (HP:0008060)1.97157274
130Hypoplasia of the fovea (HP:0007750)1.97157274
131Sparse eyelashes (HP:0000653)1.96799040
132Metaphyseal cupping (HP:0003021)1.96486054
133Abnormality of iron homeostasis (HP:0011031)1.96094551
134Difficulty running (HP:0009046)1.95054118
135Recurrent pneumonia (HP:0006532)1.93223612
136Chronic otitis media (HP:0000389)1.93034430
137Increased serum ferritin (HP:0003281)1.92519260
138Amelogenesis imperfecta (HP:0000705)1.91881268
139Optic disc pallor (HP:0000543)1.91665234
140Obstructive sleep apnea (HP:0002870)1.90861629
141Abnormal number of erythroid precursors (HP:0012131)1.90551720
142Vacuolated lymphocytes (HP:0001922)1.89416822
143Abnormality of the phalanges of the hallux (HP:0010057)1.89404060
144Prolonged bleeding time (HP:0003010)1.88152097
145Segmental peripheral demyelination/remyelination (HP:0003481)1.87229185
146IgM deficiency (HP:0002850)1.87200561
147Subacute progressive viral hepatitis (HP:0006572)1.87030434
148Congenital, generalized hypertrichosis (HP:0004540)1.86429631
149Clubbing of toes (HP:0100760)1.86393341
150Concave nail (HP:0001598)1.86138573
151Hypergonadotropic hypogonadism (HP:0000815)1.85520521
152Prolonged partial thromboplastin time (HP:0003645)1.85353988
153Hypermelanotic macule (HP:0001034)1.85300045
154Abnormality of the prostate (HP:0008775)1.84730949
155Abnormality of cells of the erythroid lineage (HP:0012130)1.84489463
156Colitis (HP:0002583)1.83146118
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82659534
158True hermaphroditism (HP:0010459)1.82342087
159Supernumerary spleens (HP:0009799)1.82108415
160Triphalangeal thumb (HP:0001199)1.81297927
161Chromosomal breakage induced by crosslinking agents (HP:0003221)1.80143546
162Skin rash (HP:0000988)1.79948643
163Cortical visual impairment (HP:0100704)1.79158911
164Flat occiput (HP:0005469)1.79065588
165Recurrent bronchitis (HP:0002837)1.78173748
166Viral hepatitis (HP:0006562)1.77792390
167Abnormal hemoglobin (HP:0011902)1.77747539
168Cheilitis (HP:0100825)1.76579009
169Progressive external ophthalmoplegia (HP:0000590)1.75772957
170Prolonged neonatal jaundice (HP:0006579)1.75475873
171Petechiae (HP:0000967)1.75247958
172Testicular atrophy (HP:0000029)1.74979443
173Abnormal ciliary motility (HP:0012262)1.74251156
174Abnormal pupillary function (HP:0007686)1.74008312
175Amniotic constriction ring (HP:0009775)1.73344519
176Abnormality of placental membranes (HP:0011409)1.73344519
177Nasolacrimal duct obstruction (HP:0000579)1.72954788
178Abnormal respiratory motile cilium morphology (HP:0005938)1.72884766
179Abnormal respiratory epithelium morphology (HP:0012253)1.72884766
180Decreased central vision (HP:0007663)1.72817274
181Recurrent skin infections (HP:0001581)1.72590501
182Pallor (HP:0000980)1.72486326
183Macrocytic anemia (HP:0001972)1.71965792
184Chronic mucocutaneous candidiasis (HP:0002728)1.69839479
185Recurrent cutaneous fungal infections (HP:0011370)1.69839479
186Prostate neoplasm (HP:0100787)1.66646442
187Hypomagnesemia (HP:0002917)1.65837037
188Increased intramyocellular lipid droplets (HP:0012240)1.64164740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.46368971
2TNIK4.04780576
3MKNK23.94100748
4MAP4K13.47407251
5MAP2K33.18664036
6EIF2AK33.08392480
7BLK3.05599609
8ERN13.05368771
9STK162.88254442
10FES2.81579795
11TYK22.71096323
12TLK12.62266732
13GRK62.53409548
14EPHB12.51085237
15NME22.48897771
16MKNK12.45210377
17IRAK32.40691175
18MUSK2.38149495
19IRAK42.36211051
20TAOK12.13669790
21MAP3K31.94205449
22MAP3K111.85654914
23NLK1.84610873
24CLK11.74049913
25JAK31.71676045
26PRPF4B1.70667077
27TEC1.68847583
28EIF2AK21.67527583
29PIM21.61698674
30MAP2K71.57729138
31YES11.52924854
32JAK21.50508014
33ADRBK21.49846359
34KSR21.47568404
35CAMKK21.45415982
36MAP3K121.44178687
37TXK1.40821943
38SIK31.38774005
39MAP3K11.35061385
40CDK191.33037482
41BMPR1B1.27628772
42MST41.26330356
43FER1.20770938
44GRK71.20698836
45IRAK11.20177643
46JAK11.17373560
47BMPR21.11796742
48PTK61.09688898
49MARK21.09291021
50EIF2AK11.09195196
51IRAK21.06430788
52CSK1.06373694
53MAPK131.01260731
54RIPK40.99501266
55SRPK10.99393158
56VRK10.99143714
57MAP3K130.99064689
58PRKD20.98093486
59CDK90.96925204
60ITK0.96094744
61CSF1R0.95607299
62KIT0.90105236
63SIK20.89813490
64CDK80.89758749
65MAP3K60.89028271
66MAP2K40.87635854
67MAP3K20.85976460
68MAP3K140.85958282
69TAOK20.85724907
70STK390.84735562
71PDK10.84228871
72TRIB30.83976604
73FGR0.82218659
74TESK20.81938150
75STK100.80686528
76PTK2B0.79424301
77SMG10.77989941
78MAPKAPK50.76487078
79BTK0.75921906
80LYN0.75622100
81PDPK10.75218449
82CAMK10.75001716
83FYN0.72695794
84LRRK20.72265341
85CDK30.71928399
86STK110.71859564
87MAP3K70.70971474
88PLK40.70817681
89GRK10.70203390
90EPHA30.67102453
91DAPK20.64005643
92PBK0.63973000
93DYRK1B0.63551594
94NEK90.62911899
95TGFBR20.62168390
96MAP3K50.61693501
97STK380.61680196
98TNK20.61679458
99PRKG20.60704763
100IKBKE0.60493928
101TAOK30.59131326
102RAF10.58078320
103CAMK2B0.57805609
104ADRBK10.57473596
105MAPK120.56625363
106PKN10.55087851
107CSNK1G10.54068558
108IKBKB0.52556661
109GRK50.52455312
110PRKCQ0.52291234
111NEK60.51799774
112MAPK40.51474928
113RET0.51348399
114SIK10.51121031
115KSR10.50594433
116NME10.49713406
117LCK0.49408996
118SGK30.49382265
119FGFR40.49333025
120MAP2K60.48627655
121SYK0.48250869
122FGFR30.47520886
123INSRR0.46890445
124CDC42BPA0.45781967
125PRKCE0.44604474
126ZAP700.44353817
127CAMK2A0.43208865
128UHMK10.43202433
129ZAK0.43051615
130PRKCZ0.42523783
131TIE10.42339643
132RPS6KC10.42105310
133RPS6KL10.42105310
134OXSR10.41297098
135HCK0.40868827
136MYLK0.40868590
137MAPK150.40466237
138MARK30.39776345
139ABL20.39207748
140MAPK70.39201737
141MAPKAPK20.38697293
142WNK40.37152656
143RPS6KA60.36916721
144CSNK1G30.36699038
145AKT30.36417109
146ALK0.36054272
147DYRK20.35558698
148DYRK1A0.35001073
149CAMK2D0.32509975
150WNK10.32379200
151CDK70.31501296
152TBK10.30884248
153DYRK30.30811214
154SGK20.30019175
155PRKCD0.29652165
156MATK0.29617531
157ABL10.29199617
158CAMKK10.28941111
159PIM10.28225028
160PIK3CG0.27381206
161BRAF0.27042299
162EPHA40.26708821
163CSNK1A1L0.26210194
164HIPK20.23925225
165PRKG10.23410506

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.20241039
2Protein export_Homo sapiens_hsa030603.15506358
3Staphylococcus aureus infection_Homo sapiens_hsa051502.85712821
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.30622733
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.23932179
6B cell receptor signaling pathway_Homo sapiens_hsa046622.20135430
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.18564871
8Other glycan degradation_Homo sapiens_hsa005112.01693529
9Basal transcription factors_Homo sapiens_hsa030221.96899836
10Oxidative phosphorylation_Homo sapiens_hsa001901.94490020
11RNA polymerase_Homo sapiens_hsa030201.91945800
12Homologous recombination_Homo sapiens_hsa034401.84431438
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.82721361
14Acute myeloid leukemia_Homo sapiens_hsa052211.75991134
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.74338722
16Sphingolipid metabolism_Homo sapiens_hsa006001.72145601
17Arachidonic acid metabolism_Homo sapiens_hsa005901.72114710
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69853679
19Fanconi anemia pathway_Homo sapiens_hsa034601.69517502
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69280985
21DNA replication_Homo sapiens_hsa030301.64083833
22Phototransduction_Homo sapiens_hsa047441.60105582
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60052948
24T cell receptor signaling pathway_Homo sapiens_hsa046601.59416434
25Type I diabetes mellitus_Homo sapiens_hsa049401.55157381
26Legionellosis_Homo sapiens_hsa051341.53078394
27Antigen processing and presentation_Homo sapiens_hsa046121.50415631
28Toxoplasmosis_Homo sapiens_hsa051451.47377254
29Influenza A_Homo sapiens_hsa051641.47257048
30Ether lipid metabolism_Homo sapiens_hsa005651.41793524
31Hematopoietic cell lineage_Homo sapiens_hsa046401.41085878
32Primary immunodeficiency_Homo sapiens_hsa053401.38350894
33Viral myocarditis_Homo sapiens_hsa054161.36869321
34Nicotine addiction_Homo sapiens_hsa050331.32072113
35Graft-versus-host disease_Homo sapiens_hsa053321.31941551
36Non-small cell lung cancer_Homo sapiens_hsa052231.29611263
37Allograft rejection_Homo sapiens_hsa053301.27064765
38Parkinsons disease_Homo sapiens_hsa050121.26699217
39TNF signaling pathway_Homo sapiens_hsa046681.26084550
40Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24523615
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.24256103
42Linoleic acid metabolism_Homo sapiens_hsa005911.19452926
43Serotonergic synapse_Homo sapiens_hsa047261.18989689
44Pyrimidine metabolism_Homo sapiens_hsa002401.17027967
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16616597
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16111996
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.15397396
48Hepatitis C_Homo sapiens_hsa051601.14465007
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14364180
50Nucleotide excision repair_Homo sapiens_hsa034201.14226075
51Hepatitis B_Homo sapiens_hsa051611.13161317
52Alzheimers disease_Homo sapiens_hsa050101.12612740
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11121573
54Pancreatic cancer_Homo sapiens_hsa052121.07473102
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.06633660
56Huntingtons disease_Homo sapiens_hsa050161.05460282
57Shigellosis_Homo sapiens_hsa051311.03636896
58Autoimmune thyroid disease_Homo sapiens_hsa053201.03444721
59Malaria_Homo sapiens_hsa051441.03394400
60Rheumatoid arthritis_Homo sapiens_hsa053231.02861324
61Intestinal immune network for IgA production_Homo sapiens_hsa046721.02445596
62Purine metabolism_Homo sapiens_hsa002301.02253930
63Long-term depression_Homo sapiens_hsa047301.00680065
64Asthma_Homo sapiens_hsa053101.00293804
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.99185994
66Chronic myeloid leukemia_Homo sapiens_hsa052200.98936728
67N-Glycan biosynthesis_Homo sapiens_hsa005100.98499310
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98491028
69VEGF signaling pathway_Homo sapiens_hsa043700.98132194
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.97637848
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96073694
72Apoptosis_Homo sapiens_hsa042100.93512238
73Endocytosis_Homo sapiens_hsa041440.90581494
74Measles_Homo sapiens_hsa051620.90472744
75Renal cell carcinoma_Homo sapiens_hsa052110.87254601
76Morphine addiction_Homo sapiens_hsa050320.85143771
77Prolactin signaling pathway_Homo sapiens_hsa049170.83479098
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.81931016
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80750240
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79811842
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.79320048
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76142878
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75833841
84Notch signaling pathway_Homo sapiens_hsa043300.75813725
85Base excision repair_Homo sapiens_hsa034100.75204865
86Glutamatergic synapse_Homo sapiens_hsa047240.74470595
87Sphingolipid signaling pathway_Homo sapiens_hsa040710.73887242
88FoxO signaling pathway_Homo sapiens_hsa040680.72883242
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.72682668
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.72466840
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72309118
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.72200285
93Mismatch repair_Homo sapiens_hsa034300.71879493
94Taste transduction_Homo sapiens_hsa047420.71688278
95Proteasome_Homo sapiens_hsa030500.71644173
96African trypanosomiasis_Homo sapiens_hsa051430.71509774
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69931965
98Phagosome_Homo sapiens_hsa041450.69371983
99Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68380053
100Regulation of autophagy_Homo sapiens_hsa041400.68187069
101Endometrial cancer_Homo sapiens_hsa052130.68157492
102Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67816066
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67550168
104Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67544731
105Leishmaniasis_Homo sapiens_hsa051400.67320913
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.66597780
107Thyroid cancer_Homo sapiens_hsa052160.64949926
108Choline metabolism in cancer_Homo sapiens_hsa052310.64241916
109Spliceosome_Homo sapiens_hsa030400.64216459
110Amoebiasis_Homo sapiens_hsa051460.63749458
111Viral carcinogenesis_Homo sapiens_hsa052030.63733076
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.61843231
113Epstein-Barr virus infection_Homo sapiens_hsa051690.61131208
114Osteoclast differentiation_Homo sapiens_hsa043800.60001799
115Herpes simplex infection_Homo sapiens_hsa051680.59762866
116Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59265568
117Ras signaling pathway_Homo sapiens_hsa040140.58278624
118Salmonella infection_Homo sapiens_hsa051320.58040640
119Dorso-ventral axis formation_Homo sapiens_hsa043200.57552556
120GnRH signaling pathway_Homo sapiens_hsa049120.57492905
121Sulfur relay system_Homo sapiens_hsa041220.56714848
122Lysosome_Homo sapiens_hsa041420.56157050
123Ovarian steroidogenesis_Homo sapiens_hsa049130.55810949
124Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55694596
125Histidine metabolism_Homo sapiens_hsa003400.55635452
126Rap1 signaling pathway_Homo sapiens_hsa040150.54445335
127Colorectal cancer_Homo sapiens_hsa052100.53501928
128HIF-1 signaling pathway_Homo sapiens_hsa040660.51384185
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.51166469
130Pertussis_Homo sapiens_hsa051330.51142906
131Wnt signaling pathway_Homo sapiens_hsa043100.50930422
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50823968
133Type II diabetes mellitus_Homo sapiens_hsa049300.50585692
134Insulin resistance_Homo sapiens_hsa049310.50175292
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50070866
136Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49389100
137Inositol phosphate metabolism_Homo sapiens_hsa005620.49251651
138MAPK signaling pathway_Homo sapiens_hsa040100.48952222
139Vitamin digestion and absorption_Homo sapiens_hsa049770.48839507
140mTOR signaling pathway_Homo sapiens_hsa041500.47020643
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46923562
142HTLV-I infection_Homo sapiens_hsa051660.46504647
143Fatty acid elongation_Homo sapiens_hsa000620.45958906
144Melanoma_Homo sapiens_hsa052180.45800201
145Non-homologous end-joining_Homo sapiens_hsa034500.44506410
146Axon guidance_Homo sapiens_hsa043600.43424300
147ErbB signaling pathway_Homo sapiens_hsa040120.42325765
148Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41272067
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.40266939
150Calcium signaling pathway_Homo sapiens_hsa040200.39975500
151Chemokine signaling pathway_Homo sapiens_hsa040620.39188199
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.39113710
153Collecting duct acid secretion_Homo sapiens_hsa049660.37500287
154Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36540958
155Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36499978
156Platelet activation_Homo sapiens_hsa046110.35614691
157Tuberculosis_Homo sapiens_hsa051520.35490218
158Insulin signaling pathway_Homo sapiens_hsa049100.35401864
159Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.29625282
160GABAergic synapse_Homo sapiens_hsa047270.28983736
161Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28789072

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