CEACAM22P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.70478135
2L-fucose catabolic process (GO:0042355)4.87306135
3fucose catabolic process (GO:0019317)4.87306135
4L-fucose metabolic process (GO:0042354)4.87306135
5response to pheromone (GO:0019236)4.31932023
6DNA deamination (GO:0045006)4.30749123
7platelet dense granule organization (GO:0060155)3.92276248
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.79704413
9water-soluble vitamin biosynthetic process (GO:0042364)3.75127504
10cellular ketone body metabolic process (GO:0046950)3.71230186
11indolalkylamine metabolic process (GO:0006586)3.64343633
12indole-containing compound catabolic process (GO:0042436)3.62099304
13indolalkylamine catabolic process (GO:0046218)3.62099304
14tryptophan catabolic process (GO:0006569)3.62099304
15detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.59905580
16negative regulation of telomere maintenance (GO:0032205)3.54618406
17respiratory chain complex IV assembly (GO:0008535)3.46290615
18preassembly of GPI anchor in ER membrane (GO:0016254)3.45825776
19piRNA metabolic process (GO:0034587)3.45510461
20ketone body metabolic process (GO:1902224)3.37678350
21kynurenine metabolic process (GO:0070189)3.37190592
22epithelial cilium movement (GO:0003351)3.24048817
23tryptophan metabolic process (GO:0006568)3.22127221
24protein polyglutamylation (GO:0018095)3.19783570
25protein-cofactor linkage (GO:0018065)3.14137474
26kidney morphogenesis (GO:0060993)3.05939770
27ubiquinone biosynthetic process (GO:0006744)3.03134513
28detection of light stimulus involved in visual perception (GO:0050908)3.02210151
29detection of light stimulus involved in sensory perception (GO:0050962)3.02210151
30regulation of nuclear cell cycle DNA replication (GO:0033262)3.01910199
31pseudouridine synthesis (GO:0001522)3.01195616
32regulation of glucokinase activity (GO:0033131)2.99483241
33regulation of hexokinase activity (GO:1903299)2.99483241
34regulation of cilium movement (GO:0003352)2.94579102
35axoneme assembly (GO:0035082)2.93934797
36rRNA catabolic process (GO:0016075)2.92726738
37cornea development in camera-type eye (GO:0061303)2.92509185
38cytochrome complex assembly (GO:0017004)2.92318080
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90997236
40neuronal action potential (GO:0019228)2.89804012
41DNA methylation involved in gamete generation (GO:0043046)2.89011635
42mitochondrial respiratory chain complex I assembly (GO:0032981)2.87157420
43NADH dehydrogenase complex assembly (GO:0010257)2.87157420
44mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87157420
45ubiquinone metabolic process (GO:0006743)2.85487144
46indole-containing compound metabolic process (GO:0042430)2.84451769
47phosphatidylinositol acyl-chain remodeling (GO:0036149)2.84181665
48protein complex biogenesis (GO:0070271)2.83613374
49adaptation of signaling pathway (GO:0023058)2.80498170
50cilium morphogenesis (GO:0060271)2.79625900
51neural tube formation (GO:0001841)2.78217603
52negative regulation of synaptic transmission, GABAergic (GO:0032229)2.78136384
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.76486323
54mannosylation (GO:0097502)2.75983850
55mitochondrial respiratory chain complex assembly (GO:0033108)2.69476792
56negative regulation of DNA-dependent DNA replication (GO:2000104)2.69075544
57cullin deneddylation (GO:0010388)2.68587660
58L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67696062
59exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.67310642
60primary amino compound metabolic process (GO:1901160)2.67142106
61regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.64655595
62regulation of mitotic spindle checkpoint (GO:1903504)2.64655595
63gamma-aminobutyric acid transport (GO:0015812)2.64483739
64photoreceptor cell maintenance (GO:0045494)2.64362886
65positive regulation of prostaglandin secretion (GO:0032308)2.64139796
66cellular biogenic amine catabolic process (GO:0042402)2.63992529
67amine catabolic process (GO:0009310)2.63992529
68negative regulation of mast cell activation (GO:0033004)2.62739636
69inositol phosphate catabolic process (GO:0071545)2.62614429
70nonmotile primary cilium assembly (GO:0035058)2.60773473
71neuronal action potential propagation (GO:0019227)2.60527630
72phosphorylated carbohydrate dephosphorylation (GO:0046838)2.60422760
73inositol phosphate dephosphorylation (GO:0046855)2.60422760
74positive regulation of fatty acid transport (GO:2000193)2.60107304
75protein deneddylation (GO:0000338)2.59811779
76regulation of rhodopsin mediated signaling pathway (GO:0022400)2.59654212
77polyol catabolic process (GO:0046174)2.58826811
78maturation of 5.8S rRNA (GO:0000460)2.57794258
79rhodopsin mediated signaling pathway (GO:0016056)2.56573995
80replication fork processing (GO:0031297)2.56506496
81behavioral response to ethanol (GO:0048149)2.55957179
82S-adenosylmethionine metabolic process (GO:0046500)2.53227537
83regulation of action potential (GO:0098900)2.53141160
84cilium movement (GO:0003341)2.52564006
85GPI anchor metabolic process (GO:0006505)2.52166696
86somatic hypermutation of immunoglobulin genes (GO:0016446)2.51845751
87somatic diversification of immune receptors via somatic mutation (GO:0002566)2.51845751
88dopamine transport (GO:0015872)2.50027535
89synaptic transmission, cholinergic (GO:0007271)2.49988249
90sulfation (GO:0051923)2.49333951
91L-methionine salvage (GO:0071267)2.48913531
92L-methionine biosynthetic process (GO:0071265)2.48913531
93amino acid salvage (GO:0043102)2.48913531
94cilium organization (GO:0044782)2.48640432
95magnesium ion transport (GO:0015693)2.46836896
96DNA double-strand break processing (GO:0000729)2.46787674
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.46728603
98protein localization to cilium (GO:0061512)2.45585047
99serotonin metabolic process (GO:0042428)2.45196143
100adenosine metabolic process (GO:0046085)2.43823435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.24081010
2VDR_22108803_ChIP-Seq_LS180_Human3.28613511
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.23423530
4IGF1R_20145208_ChIP-Seq_DFB_Human2.70352333
5GBX2_23144817_ChIP-Seq_PC3_Human2.68894300
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58095424
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.41428325
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39340738
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25988488
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.24000676
11EZH2_22144423_ChIP-Seq_EOC_Human2.20864016
12CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15254930
13* EWS_26573619_Chip-Seq_HEK293_Human2.09507479
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06274910
15FUS_26573619_Chip-Seq_HEK293_Human2.05726280
16P300_19829295_ChIP-Seq_ESCs_Human2.03800171
17TAF15_26573619_Chip-Seq_HEK293_Human1.99965556
18ER_23166858_ChIP-Seq_MCF-7_Human1.96875438
19SALL1_21062744_ChIP-ChIP_HESCs_Human1.84457593
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84323175
21NOTCH1_21737748_ChIP-Seq_TLL_Human1.83255950
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81860041
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.80717140
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76994164
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76775022
26IRF1_19129219_ChIP-ChIP_H3396_Human1.72730156
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70288411
28TP53_22573176_ChIP-Seq_HFKS_Human1.68638862
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61676291
30MYC_18940864_ChIP-ChIP_HL60_Human1.59857995
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.59556457
32AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.58146158
33CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.57572748
34BCAT_22108803_ChIP-Seq_LS180_Human1.57175455
35MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.57084608
36IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54145127
37CBP_20019798_ChIP-Seq_JUKART_Human1.54145127
38EST1_17652178_ChIP-ChIP_JURKAT_Human1.51081883
39TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46748647
40UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46343576
41STAT3_23295773_ChIP-Seq_U87_Human1.45935324
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40814505
43FOXA1_27270436_Chip-Seq_PROSTATE_Human1.39486487
44FOXA1_25329375_ChIP-Seq_VCAP_Human1.39486487
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37888173
46MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36901944
47GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.36351496
48TCF4_23295773_ChIP-Seq_U87_Human1.36219979
49SMAD4_21799915_ChIP-Seq_A2780_Human1.34835023
50NANOG_19829295_ChIP-Seq_ESCs_Human1.34043773
51SOX2_19829295_ChIP-Seq_ESCs_Human1.34043773
52AR_25329375_ChIP-Seq_VCAP_Human1.33824842
53NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33203050
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31199524
55AR_20517297_ChIP-Seq_VCAP_Human1.31195129
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30071799
57TCF4_22108803_ChIP-Seq_LS180_Human1.27360989
58ELK1_19687146_ChIP-ChIP_HELA_Human1.26270678
59NFE2_27457419_Chip-Seq_LIVER_Mouse1.26091628
60* PIAS1_25552417_ChIP-Seq_VCAP_Human1.25066960
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24395149
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24395149
63ETV2_25802403_ChIP-Seq_MESCs_Mouse1.23551711
64REST_21632747_ChIP-Seq_MESCs_Mouse1.21684756
65VDR_23849224_ChIP-Seq_CD4+_Human1.21411938
66* GATA3_21878914_ChIP-Seq_MCF-7_Human1.21088872
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.21057993
68EZH2_27294783_Chip-Seq_NPCs_Mouse1.20770899
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20356592
70NCOR_22424771_ChIP-Seq_293T_Human1.19024064
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18749430
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.17948942
73HOXB7_26014856_ChIP-Seq_BT474_Human1.17776084
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.17211309
75HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16946671
76RUNX2_22187159_ChIP-Seq_PCA_Human1.15971311
77KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15624757
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.15074246
79PRDM14_20953172_ChIP-Seq_ESCs_Human1.14133284
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12116594
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.10118923
82AUTS2_25519132_ChIP-Seq_293T-REX_Human1.09155439
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.08517079
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07870404
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.07366896
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07046767
87CDX2_22108803_ChIP-Seq_LS180_Human1.05123650
88P53_22387025_ChIP-Seq_ESCs_Mouse1.05049385
89RNF2_27304074_Chip-Seq_NSC_Mouse1.04855481
90FLI1_21867929_ChIP-Seq_TH2_Mouse1.04780389
91EGR1_23403033_ChIP-Seq_LIVER_Mouse1.03498991
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.03443914
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.03253638
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02852199
95TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02552291
96STAT3_18555785_Chip-Seq_ESCs_Mouse1.02024975
97CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99111873
98SRF_21415370_ChIP-Seq_HL-1_Mouse0.98802985
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95894676
100MYC_19829295_ChIP-Seq_ESCs_Human0.95009138

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.69776569
2MP0003195_calcinosis3.07342512
3MP0002102_abnormal_ear_morphology2.75977506
4MP0003787_abnormal_imprinting2.61782476
5MP0001968_abnormal_touch/_nociception2.43539757
6MP0005551_abnormal_eye_electrophysiolog2.40243168
7MP0002876_abnormal_thyroid_physiology2.28302827
8MP0006072_abnormal_retinal_apoptosis2.20376151
9MP0002837_dystrophic_cardiac_calcinosis2.10567678
10MP0005645_abnormal_hypothalamus_physiol2.06357068
11MP0002736_abnormal_nociception_after2.00846362
12MP0002138_abnormal_hepatobiliary_system2.00616993
13MP0008872_abnormal_physiological_respon1.98776737
14MP0008875_abnormal_xenobiotic_pharmacok1.93527723
15MP0001986_abnormal_taste_sensitivity1.93010590
16MP0003646_muscle_fatigue1.87792473
17MP0005253_abnormal_eye_physiology1.86590437
18MP0004147_increased_porphyrin_level1.84141603
19MP0000427_abnormal_hair_cycle1.83575151
20MP0004043_abnormal_pH_regulation1.83414719
21MP0005646_abnormal_pituitary_gland1.78938419
22MP0004885_abnormal_endolymph1.78701701
23MP0001501_abnormal_sleep_pattern1.78307795
24MP0009745_abnormal_behavioral_response1.78117205
25MP0003011_delayed_dark_adaptation1.75184297
26MP0003880_abnormal_central_pattern1.69590740
27MP0009046_muscle_twitch1.68137787
28MP0006292_abnormal_olfactory_placode1.65369836
29MP0005084_abnormal_gallbladder_morpholo1.63377455
30MP0002272_abnormal_nervous_system1.62512006
31MP0000569_abnormal_digit_pigmentation1.62503702
32MP0002653_abnormal_ependyma_morphology1.61154520
33MP0010386_abnormal_urinary_bladder1.56450749
34MP0000372_irregular_coat_pigmentation1.56403758
35MP0004133_heterotaxia1.55827112
36MP0004142_abnormal_muscle_tone1.55401098
37MP0001984_abnormal_olfaction1.47495250
38MP0002638_abnormal_pupillary_reflex1.42246029
39MP0001486_abnormal_startle_reflex1.41615412
40MP0001485_abnormal_pinna_reflex1.38118191
41MP0006276_abnormal_autonomic_nervous1.36065283
42MP0003718_maternal_effect1.35983611
43MP0000631_abnormal_neuroendocrine_gland1.35808240
44MP0002234_abnormal_pharynx_morphology1.35107336
45MP0003136_yellow_coat_color1.34533044
46MP0002938_white_spotting1.33307950
47MP0003283_abnormal_digestive_organ1.27112056
48MP0005085_abnormal_gallbladder_physiolo1.25918343
49MP0001529_abnormal_vocalization1.24202585
50MP0005379_endocrine/exocrine_gland_phen1.22915124
51MP0002572_abnormal_emotion/affect_behav1.19126022
52MP0005174_abnormal_tail_pigmentation1.18389340
53MP0008058_abnormal_DNA_repair1.18316762
54MP0002557_abnormal_social/conspecific_i1.17404411
55MP0005389_reproductive_system_phenotype1.13786090
56MP0001764_abnormal_homeostasis1.13656508
57MP0002064_seizures1.13578616
58MP0002733_abnormal_thermal_nociception1.12729642
59MP0001970_abnormal_pain_threshold1.12394424
60MP0004145_abnormal_muscle_electrophysio1.11123966
61MP0002928_abnormal_bile_duct1.09506453
62MP0005365_abnormal_bile_salt1.05526835
63MP0005410_abnormal_fertilization1.05329025
64MP0003878_abnormal_ear_physiology1.04797736
65MP0005377_hearing/vestibular/ear_phenot1.04797736
66MP0004742_abnormal_vestibular_system1.04734916
67MP0002160_abnormal_reproductive_system1.04072317
68MP0002163_abnormal_gland_morphology1.02496667
69MP0005167_abnormal_blood-brain_barrier1.01440755
70MP0005332_abnormal_amino_acid0.99277736
71MP0002277_abnormal_respiratory_mucosa0.96043827
72MP0008789_abnormal_olfactory_epithelium0.95710873
73MP0000647_abnormal_sebaceous_gland0.95178193
74MP0003121_genomic_imprinting0.95005029
75MP0002751_abnormal_autonomic_nervous0.95000789
76MP0000383_abnormal_hair_follicle0.93983878
77MP0001919_abnormal_reproductive_system0.93307197
78MP0002067_abnormal_sensory_capabilities0.93027157
79MP0000230_abnormal_systemic_arterial0.92867446
80MP0008995_early_reproductive_senescence0.92770375
81MP0005195_abnormal_posterior_eye0.90639453
82MP0003252_abnormal_bile_duct0.90003969
83MP0002254_reproductive_system_inflammat0.89538868
84MP0004215_abnormal_myocardial_fiber0.88648370
85MP0005386_behavior/neurological_phenoty0.88165708
86MP0004924_abnormal_behavior0.88165708
87MP0008775_abnormal_heart_ventricle0.87918067
88MP0001929_abnormal_gametogenesis0.87015560
89MP0010329_abnormal_lipoprotein_level0.85136838
90MP0005671_abnormal_response_to0.84973427
91MP0003137_abnormal_impulse_conducting0.84353268
92MP0002735_abnormal_chemical_nociception0.84259512
93MP0003698_abnormal_male_reproductive0.83368848
94MP0002095_abnormal_skin_pigmentation0.83204209
95MP0002693_abnormal_pancreas_physiology0.81937304
96MP0002734_abnormal_mechanical_nocicepti0.81176228
97MP0001905_abnormal_dopamine_level0.78352455
98MP0000538_abnormal_urinary_bladder0.77623521
99MP0003635_abnormal_synaptic_transmissio0.75899864
100MP0002063_abnormal_learning/memory/cond0.75734952

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.48743439
2Molar tooth sign on MRI (HP:0002419)4.14507533
3Abnormality of midbrain morphology (HP:0002418)4.14507533
4Pancreatic fibrosis (HP:0100732)4.10718145
5True hermaphroditism (HP:0010459)3.77674143
6Nephronophthisis (HP:0000090)3.76943667
7Congenital stationary night blindness (HP:0007642)3.56313982
8Abnormality of the renal cortex (HP:0011035)3.39197868
9Type II lissencephaly (HP:0007260)3.35082913
10Abnormality of the renal medulla (HP:0100957)3.29246783
11Medial flaring of the eyebrow (HP:0010747)3.13933725
12Hyperventilation (HP:0002883)3.05337732
13Tubular atrophy (HP:0000092)2.98940713
14Abnormal drinking behavior (HP:0030082)2.94978681
15Polydipsia (HP:0001959)2.94978681
16Attenuation of retinal blood vessels (HP:0007843)2.93265768
17Chronic hepatic failure (HP:0100626)2.86797377
18Abnormality of alanine metabolism (HP:0010916)2.71575600
19Hyperalaninemia (HP:0003348)2.71575600
20Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71575600
21Abolished electroretinogram (ERG) (HP:0000550)2.71040985
22Cystic liver disease (HP:0006706)2.66918177
23Large for gestational age (HP:0001520)2.65619170
24Pendular nystagmus (HP:0012043)2.58625724
25Progressive inability to walk (HP:0002505)2.53381690
26Inability to walk (HP:0002540)2.52239956
27Renal cortical cysts (HP:0000803)2.49489656
28Abnormal rod and cone electroretinograms (HP:0008323)2.48920017
29Absent/shortened dynein arms (HP:0200106)2.40302895
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.40302895
31Lissencephaly (HP:0001339)2.39534360
32Methylmalonic acidemia (HP:0002912)2.38200092
33Polyuria (HP:0000103)2.36593611
34Gaze-evoked nystagmus (HP:0000640)2.36010558
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.31262052
36Gait imbalance (HP:0002141)2.30257736
37Acute necrotizing encephalopathy (HP:0006965)2.26960494
38Keratoconus (HP:0000563)2.26634082
39Increased corneal curvature (HP:0100692)2.26634082
40Congenital hepatic fibrosis (HP:0002612)2.23064458
41Congenital primary aphakia (HP:0007707)2.22838477
42Bile duct proliferation (HP:0001408)2.21391275
43Abnormal biliary tract physiology (HP:0012439)2.21391275
44Ketoacidosis (HP:0001993)2.19484321
45Sclerocornea (HP:0000647)2.18393939
46Increased CSF lactate (HP:0002490)2.16062945
47Acute encephalopathy (HP:0006846)2.15842624
48Methylmalonic aciduria (HP:0012120)2.14519209
49Cerebellar dysplasia (HP:0007033)2.13201356
50Congenital, generalized hypertrichosis (HP:0004540)2.12747547
51Hyperglycinuria (HP:0003108)2.12147436
52Hypothermia (HP:0002045)2.11864071
53Aplasia/Hypoplasia of the tongue (HP:0010295)2.10476902
54Nephrogenic diabetes insipidus (HP:0009806)2.10394511
55Intestinal atresia (HP:0011100)2.10010541
56Absent rod-and cone-mediated responses on ERG (HP:0007688)2.08425170
57Progressive macrocephaly (HP:0004481)2.07835298
58Mitochondrial inheritance (HP:0001427)2.06217152
59Pachygyria (HP:0001302)2.05926608
60Stomach cancer (HP:0012126)2.05889721
61Retinal dysplasia (HP:0007973)2.05683427
62Colon cancer (HP:0003003)2.01265867
63Furrowed tongue (HP:0000221)2.00671795
64Hemiparesis (HP:0001269)1.99556108
65Decreased circulating renin level (HP:0003351)1.98868565
66Decreased central vision (HP:0007663)1.98557152
67Hypomagnesemia (HP:0002917)1.98505828
68Optic disc pallor (HP:0000543)1.97143274
69Severe muscular hypotonia (HP:0006829)1.96239950
70Ketosis (HP:0001946)1.95653738
71Fair hair (HP:0002286)1.93333804
72Chorioretinal atrophy (HP:0000533)1.91961983
73Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.90738278
74Aplasia/Hypoplasia of the tibia (HP:0005772)1.90261240
75Anencephaly (HP:0002323)1.89912578
76Abnormal urine output (HP:0012590)1.89631315
77Aplasia/Hypoplasia of the spleen (HP:0010451)1.89533871
78Bony spicule pigmentary retinopathy (HP:0007737)1.89327626
79Broad-based gait (HP:0002136)1.88558668
80Febrile seizures (HP:0002373)1.85366448
81Abnormal respiratory motile cilium morphology (HP:0005938)1.83146082
82Abnormal respiratory epithelium morphology (HP:0012253)1.83146082
833-Methylglutaconic aciduria (HP:0003535)1.82099425
84Abnormal mitochondria in muscle tissue (HP:0008316)1.81679470
85Concave nail (HP:0001598)1.80051407
86Male pseudohermaphroditism (HP:0000037)1.78796582
87Progressive microcephaly (HP:0000253)1.78673188
88Abnormality of the pons (HP:0007361)1.77948995
89Genital tract atresia (HP:0001827)1.77715842
90Postaxial foot polydactyly (HP:0001830)1.76292300
91Optic nerve hypoplasia (HP:0000609)1.76028379
92Abnormality of glycine metabolism (HP:0010895)1.75614657
93Abnormality of serine family amino acid metabolism (HP:0010894)1.75614657
94Increased serum lactate (HP:0002151)1.75537840
95Hypoplasia of the pons (HP:0012110)1.75297558
96Lipid accumulation in hepatocytes (HP:0006561)1.74783623
97Agitation (HP:0000713)1.74229991
98Patellar aplasia (HP:0006443)1.74151896
99Thyroiditis (HP:0100646)1.74127239
100Tachypnea (HP:0002789)1.71267548

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.34711679
2ADRBK23.19117545
3MAP4K23.13691515
4BMPR1B2.78295578
5TAOK32.65975699
6ZAK2.48351116
7WNK42.41266582
8WNK32.38825520
9GRK12.34360665
10NUAK12.22504541
11PINK12.21042362
12INSRR2.20995249
13TLK12.19061653
14ACVR1B2.12399367
15OXSR11.82587198
16DAPK21.80242853
17TNIK1.74381848
18STK391.72886455
19MKNK21.65841908
20MAP3K41.60786753
21MAPK131.58613035
22TXK1.57415123
23TRIM281.47770321
24CASK1.34481508
25MST41.31657884
26ADRBK11.19327071
27PAK31.18928492
28PLK21.15448947
29PHKG21.13760628
30PHKG11.13760628
31DYRK21.09117456
32EIF2AK31.07349084
33PRKCE1.02728004
34PRKCG0.99846851
35BCKDK0.96953916
36CAMKK20.96708445
37BCR0.96022373
38CSNK1G20.92795002
39CSNK1G10.89799524
40MKNK10.89286572
41CSNK1G30.88564215
42ERBB30.86893273
43TGFBR10.85351632
44TAF10.84623342
45TIE10.83219376
46STK38L0.79752979
47VRK10.79284707
48VRK20.79273584
49MARK10.77727860
50MAPKAPK30.76685312
51PTK2B0.76242417
52PIK3CA0.75941770
53CSNK1A1L0.75050454
54IKBKB0.71786169
55PLK40.71134746
56PLK30.70914367
57MAP2K70.66313360
58TEC0.64933705
59NME10.63382261
60PRKCI0.62438622
61AKT30.61667511
62KIT0.60717159
63GRK70.60364778
64BRSK20.59780411
65MAPKAPK50.59764527
66PNCK0.58703817
67TSSK60.53311830
68FGFR20.53147038
69STK30.52990389
70NTRK30.52534885
71EIF2AK20.51453970
72CAMK2A0.51057220
73PRKCQ0.50085545
74EPHA40.49306213
75MAP2K60.48826016
76IRAK10.48520487
77RPS6KA50.48066680
78STK160.47876425
79PRKACA0.42750287
80EPHA30.42425758
81CSNK1A10.42359208
82GRK50.41176353
83ITK0.39551523
84CHUK0.39166751
85PLK10.38877594
86FLT30.38284048
87CSNK1D0.37619257
88STK110.36299399
89CAMK10.34316324
90PKN10.33681785
91ATR0.32303370
92DAPK10.31852087
93IRAK40.31831550
94PRKCA0.31705730
95FER0.31408216
96MUSK0.31054943
97CHEK20.30688470
98NLK0.29869616
99PRKG10.29712953
100OBSCN0.29349028

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.85608191
2alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63139113
3Linoleic acid metabolism_Homo sapiens_hsa005912.62808538
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.50678746
5Nitrogen metabolism_Homo sapiens_hsa009102.43045667
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42776318
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.39760879
8Butanoate metabolism_Homo sapiens_hsa006502.27992705
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.19559949
10Protein export_Homo sapiens_hsa030602.18607931
11Oxidative phosphorylation_Homo sapiens_hsa001902.14775329
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.03036475
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02285348
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.00316303
15RNA polymerase_Homo sapiens_hsa030201.95672941
16Tryptophan metabolism_Homo sapiens_hsa003801.84953204
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83843620
18Ether lipid metabolism_Homo sapiens_hsa005651.83101729
19Propanoate metabolism_Homo sapiens_hsa006401.76877027
20Selenocompound metabolism_Homo sapiens_hsa004501.76562613
21Nicotine addiction_Homo sapiens_hsa050331.74218317
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73781990
23Basal transcription factors_Homo sapiens_hsa030221.62483951
24Parkinsons disease_Homo sapiens_hsa050121.56717868
25Homologous recombination_Homo sapiens_hsa034401.55860015
26Caffeine metabolism_Homo sapiens_hsa002321.52679344
27Fanconi anemia pathway_Homo sapiens_hsa034601.51831254
28Intestinal immune network for IgA production_Homo sapiens_hsa046721.48576476
29Peroxisome_Homo sapiens_hsa041461.46204960
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.40665416
31RNA degradation_Homo sapiens_hsa030181.40619734
32Asthma_Homo sapiens_hsa053101.28456374
33One carbon pool by folate_Homo sapiens_hsa006701.20421415
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.19125376
35Arachidonic acid metabolism_Homo sapiens_hsa005901.17404260
36Taste transduction_Homo sapiens_hsa047421.16426489
37Regulation of autophagy_Homo sapiens_hsa041401.16351585
38Primary bile acid biosynthesis_Homo sapiens_hsa001201.16158768
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13627097
40Olfactory transduction_Homo sapiens_hsa047401.10984918
41Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.10745857
42Chemical carcinogenesis_Homo sapiens_hsa052041.04443418
43Morphine addiction_Homo sapiens_hsa050321.02317799
44Huntingtons disease_Homo sapiens_hsa050161.02121386
45Collecting duct acid secretion_Homo sapiens_hsa049661.01370800
46Sulfur metabolism_Homo sapiens_hsa009200.97982000
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97380091
48Non-homologous end-joining_Homo sapiens_hsa034500.97192335
49ABC transporters_Homo sapiens_hsa020100.95930229
50Steroid hormone biosynthesis_Homo sapiens_hsa001400.94444031
51Alzheimers disease_Homo sapiens_hsa050100.94043149
52beta-Alanine metabolism_Homo sapiens_hsa004100.91315692
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.89751451
54Retinol metabolism_Homo sapiens_hsa008300.89741446
55Insulin secretion_Homo sapiens_hsa049110.83897612
56Proteasome_Homo sapiens_hsa030500.82229605
57Cardiac muscle contraction_Homo sapiens_hsa042600.81261887
58Serotonergic synapse_Homo sapiens_hsa047260.80947512
59Circadian entrainment_Homo sapiens_hsa047130.79489739
60Purine metabolism_Homo sapiens_hsa002300.79129453
61Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77841118
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77359568
63Ovarian steroidogenesis_Homo sapiens_hsa049130.76119771
64Type I diabetes mellitus_Homo sapiens_hsa049400.75386605
65Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.74316582
66Fat digestion and absorption_Homo sapiens_hsa049750.72969066
67Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71340731
68GABAergic synapse_Homo sapiens_hsa047270.70837586
69Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70595989
70Glutamatergic synapse_Homo sapiens_hsa047240.68860782
71Metabolic pathways_Homo sapiens_hsa011000.68077494
72Sulfur relay system_Homo sapiens_hsa041220.63041432
73Allograft rejection_Homo sapiens_hsa053300.62530343
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.60882149
75Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60654270
76Autoimmune thyroid disease_Homo sapiens_hsa053200.59730481
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59582807
78Cysteine and methionine metabolism_Homo sapiens_hsa002700.58837500
79Pyrimidine metabolism_Homo sapiens_hsa002400.57702966
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57639066
81Steroid biosynthesis_Homo sapiens_hsa001000.56755665
82Primary immunodeficiency_Homo sapiens_hsa053400.56021630
83Histidine metabolism_Homo sapiens_hsa003400.55904456
84Circadian rhythm_Homo sapiens_hsa047100.54219804
85Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54156512
86Salivary secretion_Homo sapiens_hsa049700.53983457
87Vitamin B6 metabolism_Homo sapiens_hsa007500.52860428
88Fatty acid degradation_Homo sapiens_hsa000710.48785187
89Glycerolipid metabolism_Homo sapiens_hsa005610.48688657
90Fatty acid elongation_Homo sapiens_hsa000620.48171290
91Calcium signaling pathway_Homo sapiens_hsa040200.45779265
92Graft-versus-host disease_Homo sapiens_hsa053320.44824244
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.44612443
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42844859
95Mineral absorption_Homo sapiens_hsa049780.42025220
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.40064239
97Dorso-ventral axis formation_Homo sapiens_hsa043200.39474676
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39342875
99Long-term depression_Homo sapiens_hsa047300.37262163
100Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35370903

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