CDYL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)5.42362521
2dosage compensation (GO:0007549)4.89307531
3regulation of helicase activity (GO:0051095)4.71305179
4histone H4-K12 acetylation (GO:0043983)3.90062710
5regulation of gene silencing by RNA (GO:0060966)3.87881543
6regulation of posttranscriptional gene silencing (GO:0060147)3.87881543
7regulation of gene silencing by miRNA (GO:0060964)3.87881543
8snRNA transcription (GO:0009301)3.78807484
9nuclear pore organization (GO:0006999)3.77764906
10negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.69989292
11DNA replication initiation (GO:0006270)3.67981741
12protein localization to endosome (GO:0036010)3.66512204
13nuclear pore complex assembly (GO:0051292)3.63770132
14regulation of chromatin binding (GO:0035561)3.58156688
15positive regulation of keratinocyte differentiation (GO:0045618)3.55895847
16histone arginine methylation (GO:0034969)3.49668228
17somatic diversification of immune receptors via somatic mutation (GO:0002566)3.49120498
18somatic hypermutation of immunoglobulin genes (GO:0016446)3.49120498
19DNA replication-dependent nucleosome organization (GO:0034723)3.47294266
20DNA replication-dependent nucleosome assembly (GO:0006335)3.47294266
21regulation of ARF protein signal transduction (GO:0032012)3.44814487
22synaptic vesicle docking involved in exocytosis (GO:0016081)3.41265102
23negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.40452936
24retina vasculature morphogenesis in camera-type eye (GO:0061299)3.37134051
25determination of adult lifespan (GO:0008340)3.31806113
26insulin-like growth factor receptor signaling pathway (GO:0048009)3.29793669
27iron ion import (GO:0097286)3.29416063
28negative regulation of histone methylation (GO:0031061)3.29112781
29DNA replication checkpoint (GO:0000076)3.27374514
30regulation of meiosis I (GO:0060631)3.25098756
31peptidyl-arginine N-methylation (GO:0035246)3.17882450
32peptidyl-arginine methylation (GO:0018216)3.17882450
33regulation of telomere maintenance via telomerase (GO:0032210)3.17270378
34intra-S DNA damage checkpoint (GO:0031573)3.15237672
35DNA unwinding involved in DNA replication (GO:0006268)3.14443975
36regulation of centriole replication (GO:0046599)3.13692402
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.12748873
38inner cell mass cell proliferation (GO:0001833)3.11023832
39positive regulation of DNA-templated transcription, elongation (GO:0032786)3.07483023
40establishment of integrated proviral latency (GO:0075713)3.07303017
41vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.07205647
42nucleobase biosynthetic process (GO:0046112)3.06077997
43pre-miRNA processing (GO:0031054)3.05657460
44regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)3.05572708
45cytoskeletal anchoring at plasma membrane (GO:0007016)3.05109195
46centriole replication (GO:0007099)3.01408061
47ribosome biogenesis (GO:0042254)3.01386217
48negative regulation of androgen receptor signaling pathway (GO:0060766)2.97686426
49maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.97564755
50cellular response to ethanol (GO:0071361)2.96995721
51regulation of histone H3-K9 methylation (GO:0051570)2.96271690
52anterior/posterior axis specification, embryo (GO:0008595)2.94794703
53positive regulation of mitotic sister chromatid separation (GO:1901970)2.94439953
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94439953
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94439953
56regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.93458517
57regulation of double-strand break repair via homologous recombination (GO:0010569)2.93032455
58lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92502226
59protein K6-linked ubiquitination (GO:0085020)2.91220938
60peptidyl-arginine omega-N-methylation (GO:0035247)2.91160564
61positive regulation of chromosome segregation (GO:0051984)2.91158244
62olfactory bulb development (GO:0021772)2.90423768
63endothelial cell chemotaxis (GO:0035767)2.89602546
64negative regulation of chromatin modification (GO:1903309)2.88703410
65regulation of NFAT protein import into nucleus (GO:0051532)2.84216021
66purine nucleobase biosynthetic process (GO:0009113)2.82974384
67negative regulation of gene silencing (GO:0060969)2.80049238
68glutamate secretion (GO:0014047)2.79150016
69negative regulation of histone modification (GO:0031057)2.78351754
70DNA strand elongation involved in DNA replication (GO:0006271)2.77711564
71regulation of establishment of cell polarity (GO:2000114)2.77707324
72replication fork processing (GO:0031297)2.77020503
73histone H4-K8 acetylation (GO:0043982)2.76772235
74histone H4-K5 acetylation (GO:0043981)2.76772235
75regulation of vitamin D biosynthetic process (GO:0060556)2.74848382
76regulation of DNA methylation (GO:0044030)2.73773942
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.73568520
78endothelium development (GO:0003158)2.73355531
79cullin deneddylation (GO:0010388)2.73162937
80regulation of establishment or maintenance of cell polarity (GO:0032878)2.72483288
81cell adhesion mediated by integrin (GO:0033627)2.71928082
82histone H3-K36 demethylation (GO:0070544)2.71910668
83regulation of histone H3-K27 methylation (GO:0061085)2.69324658
84DNA geometric change (GO:0032392)2.68801066
85DNA duplex unwinding (GO:0032508)2.67112122
86positive regulation of neurotransmitter secretion (GO:0001956)2.67090953
87regulation of double-strand break repair (GO:2000779)2.65931131
88formation of translation preinitiation complex (GO:0001731)2.65066522
89negative regulation of DNA-dependent DNA replication (GO:2000104)2.64542414
90regulation of translational termination (GO:0006449)2.64037100
91DNA strand elongation (GO:0022616)2.64022249
92positive regulation of SMAD protein import into nucleus (GO:0060391)2.63454140
93establishment of protein localization to mitochondrial membrane (GO:0090151)2.63128108
94regulation of T-helper 2 cell differentiation (GO:0045628)2.63010255
95pore complex assembly (GO:0046931)2.62338915
96mitotic nuclear envelope disassembly (GO:0007077)2.62145196
97regulation of clathrin-mediated endocytosis (GO:2000369)2.62055017
98negative regulation of focal adhesion assembly (GO:0051895)2.61639873
99negative regulation of cell junction assembly (GO:1901889)2.61639873
100negative regulation of adherens junction organization (GO:1903392)2.61639873
101regulation of gene silencing (GO:0060968)2.61450618
102negative regulation of signal transduction by p53 class mediator (GO:1901797)2.61084634
103regulation of centrosome cycle (GO:0046605)2.60131418
104establishment of monopolar cell polarity (GO:0061162)2.59829099
105establishment or maintenance of monopolar cell polarity (GO:0061339)2.59829099
106microtubule depolymerization (GO:0007019)2.58885425
107DNA ligation (GO:0006266)2.57735111
108ribosome assembly (GO:0042255)2.57444248
109positive regulation of Cdc42 GTPase activity (GO:0043089)2.57343819
110non-recombinational repair (GO:0000726)2.56753261
111double-strand break repair via nonhomologous end joining (GO:0006303)2.56753261
112IMP biosynthetic process (GO:0006188)2.55858927
113mitotic sister chromatid segregation (GO:0000070)2.54244639
114positive regulation of smooth muscle cell migration (GO:0014911)2.53369288
115mitotic metaphase plate congression (GO:0007080)2.52033528
116positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.51935762
117JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.51757122
118response to laminar fluid shear stress (GO:0034616)2.51329085
119negative regulation by host of viral transcription (GO:0043922)2.51267048
120regulation of centrosome duplication (GO:0010824)2.50978646
121response to peptidoglycan (GO:0032494)2.49767930
122protein deneddylation (GO:0000338)2.49110347
123centriole assembly (GO:0098534)2.48971271
124mRNA cleavage (GO:0006379)2.48614959
125activation of Rac GTPase activity (GO:0032863)2.48094310
126notochord development (GO:0030903)2.48078899
127ribonucleoprotein complex biogenesis (GO:0022613)2.47637353
128barbed-end actin filament capping (GO:0051016)2.47533502
129regulation of gene expression by genetic imprinting (GO:0006349)2.47025856
130membrane disassembly (GO:0030397)2.46485934
131nuclear envelope disassembly (GO:0051081)2.46485934
132histone H2A acetylation (GO:0043968)2.45960671
133reciprocal meiotic recombination (GO:0007131)2.45818532
134reciprocal DNA recombination (GO:0035825)2.45818532
135negative regulation of fatty acid transport (GO:2000192)2.45597051
136hepatocyte apoptotic process (GO:0097284)2.40579119
137response to acidic pH (GO:0010447)2.39246798
138cortical actin cytoskeleton organization (GO:0030866)2.38875133
139epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36617390
140regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.35500829
141mannose metabolic process (GO:0006013)2.34298414
142positive regulation of blood vessel endothelial cell migration (GO:0043536)2.34143623
143negative regulation of interleukin-12 production (GO:0032695)2.33223515
144positive regulation of nitric-oxide synthase activity (GO:0051000)2.32593351
145negative regulation of cell-matrix adhesion (GO:0001953)2.31307719
146embryonic process involved in female pregnancy (GO:0060136)2.30857587
147vascular endothelial growth factor signaling pathway (GO:0038084)2.30696300
148establishment of endothelial barrier (GO:0061028)2.30368816
149TOR signaling (GO:0031929)2.30180146
150negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.29068977
151negative regulation of vascular permeability (GO:0043116)2.28788709
152negative regulation of erythrocyte differentiation (GO:0045647)2.27190316
153regulation of T-helper 1 cell differentiation (GO:0045625)2.24627452
154regulation of membrane protein ectodomain proteolysis (GO:0051043)2.23523953
155regulation of early endosome to late endosome transport (GO:2000641)2.22509997
156germinal center formation (GO:0002467)2.21804825
157wound healing, spreading of epidermal cells (GO:0035313)2.21623119
158positive regulation of nitric oxide biosynthetic process (GO:0045429)2.20276830
159positive regulation of Rap GTPase activity (GO:0032854)2.20008698
160positive regulation of neurotransmitter transport (GO:0051590)2.19220929
161positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.18711769
162regulation of podosome assembly (GO:0071801)2.15303928
163L-amino acid import (GO:0043092)2.13326617
164macroautophagy (GO:0016236)2.12913083
165Golgi transport vesicle coating (GO:0048200)2.12875463
166COPI coating of Golgi vesicle (GO:0048205)2.12875463
167platelet-derived growth factor receptor signaling pathway (GO:0048008)2.12241289
168sphingosine metabolic process (GO:0006670)2.12140200
169synaptic vesicle exocytosis (GO:0016079)2.12020722
170import into cell (GO:0098657)2.11998181
171negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.11738243
172cellular response to interferon-alpha (GO:0035457)2.11516945
173adherens junction assembly (GO:0034333)2.11075834
174amino acid import (GO:0043090)2.11045004
175response to magnesium ion (GO:0032026)2.10032651
176positive regulation of receptor recycling (GO:0001921)2.09860533
177Rap protein signal transduction (GO:0032486)2.07660504
178lipid translocation (GO:0034204)2.06000516
179phospholipid translocation (GO:0045332)2.06000516
180stress fiber assembly (GO:0043149)2.05639661
181regulation of integrin activation (GO:0033623)2.05512532
182regulation of nitric oxide biosynthetic process (GO:0045428)2.05388165
183T-helper cell differentiation (GO:0042093)2.05125199
184CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.05125199
185synaptic vesicle maturation (GO:0016188)2.03646969
186ovulation from ovarian follicle (GO:0001542)2.02475246
187regulation of ARF GTPase activity (GO:0032312)2.02126852
188cortical cytoskeleton organization (GO:0030865)2.01291096
189branching involved in mammary gland duct morphogenesis (GO:0060444)2.01053793
190focal adhesion assembly (GO:0048041)2.00710668
191cell-substrate adherens junction assembly (GO:0007045)2.00710668
192endocrine hormone secretion (GO:0060986)2.00041960
193positive regulation of epidermal cell differentiation (GO:0045606)1.99885802
194positive regulation of transcription from RNA polymerase III promoter (GO:0045945)1.99607278
195endocytic recycling (GO:0032456)1.99122175
196prostate gland growth (GO:0060736)1.99034812
197positive regulation of fibroblast migration (GO:0010763)1.96781930
198macrophage activation involved in immune response (GO:0002281)1.96681967
199ear development (GO:0043583)1.96200890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.30614655
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.10587465
3ESR2_21235772_ChIP-Seq_MCF-7_Human3.95075486
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.63666240
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.63666240
6KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.63666240
7ESR1_20079471_ChIP-ChIP_T-47D_Human3.58435506
8NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.33653387
9SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.32787099
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24510633
11SALL1_21062744_ChIP-ChIP_HESCs_Human3.05402163
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.00860291
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.98833780
14NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.96043955
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.89792909
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.76505398
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.69467169
18* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.65616259
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.61777796
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.52746895
21SOX2_18555785_ChIP-Seq_MESCs_Mouse2.49618317
22SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.48524311
23* TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.45241407
24* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37540160
25* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.35005774
26NANOG_18555785_ChIP-Seq_MESCs_Mouse2.30028590
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.28491811
28* AHR_22903824_ChIP-Seq_MCF-7_Human2.24844047
29GATA2_21666600_ChIP-Seq_HMVEC_Human2.24210036
30FOXM1_23109430_ChIP-Seq_U2OS_Human2.20083030
31ZNF263_19887448_ChIP-Seq_K562_Human2.18060931
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.17592924
33KDM2B_26808549_Chip-Seq_SUP-B15_Human2.14387781
34ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.12355483
35SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.08568009
36TP63_19390658_ChIP-ChIP_HaCaT_Human2.07559180
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.07311814
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.07293575
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.04486651
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.04049185
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01887556
42ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.95806507
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.93819110
44NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92343497
45TCF7_22412390_ChIP-Seq_EML_Mouse1.89657297
46NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.83553677
47VDR_23849224_ChIP-Seq_CD4+_Human1.83294003
48SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.83112901
49TCF3_18692474_ChIP-Seq_MEFs_Mouse1.82234974
50* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.81195571
51EST1_17652178_ChIP-ChIP_JURKAT_Human1.80837681
52RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80718712
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.80210084
54Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.79793113
55STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78653000
56MYC_18358816_ChIP-ChIP_MESCs_Mouse1.78540935
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.77323526
58KDM2B_26808549_Chip-Seq_K562_Human1.75538280
59FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75440423
60KDM2B_26808549_Chip-Seq_DND41_Human1.74609248
61* ARNT_22903824_ChIP-Seq_MCF-7_Human1.74223040
62KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68714242
63FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.67504327
64NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.67157463
65RUNX1_27514584_Chip-Seq_MCF-7_Human1.66632787
66JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65600759
67MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61617802
68RACK7_27058665_Chip-Seq_MCF-7_Human1.60707170
69E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58588114
70YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55713010
71STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.55660204
72ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53920884
73ETS1_20019798_ChIP-Seq_JURKAT_Human1.52702066
74FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51923039
75STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51568541
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.51408092
77XRN2_22483619_ChIP-Seq_HELA_Human1.50519908
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49351915
79E2F1_21310950_ChIP-Seq_MCF-7_Human1.48472349
80SCL_19346495_ChIP-Seq_HPC-7_Human1.47437631
81FOXP3_21729870_ChIP-Seq_TREG_Human1.47366716
82NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.45131864
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44890883
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43570110
85EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43233873
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42943412
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42932746
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41824380
89POU5F1_16518401_ChIP-PET_MESCs_Mouse1.40905080
90GATA1_22025678_ChIP-Seq_K562_Human1.39111916
91POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.38947352
92GABP_17652178_ChIP-ChIP_JURKAT_Human1.38702454
93* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38240763
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.37565730
95TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.37505720
96SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36903917
97IRF8_27001747_Chip-Seq_BMDM_Mouse1.36332039
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35503291
99* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35173753
100TTF2_22483619_ChIP-Seq_HELA_Human1.34566647
101RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34443788
102SOX2_18692474_ChIP-Seq_MESCs_Mouse1.33791323
103KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33154717
104HIF1A_21447827_ChIP-Seq_MCF-7_Human1.32765865
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32375137
106HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31668848
107IRF8_22096565_ChIP-ChIP_GC-B_Human1.31661940
108KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.30957584
109IRF8_21731497_ChIP-ChIP_J774_Mouse1.30318465
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29597627
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28447652
112SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28447652
113THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27581995
114VDR_21846776_ChIP-Seq_THP-1_Human1.26482896
115SPI1_23127762_ChIP-Seq_K562_Human1.25727426
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.25439130
117ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24892741
118SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24473054
119HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24321902
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23604447
121MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23333351
122TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.23232622
123PPAR_26484153_Chip-Seq_NCI-H1993_Human1.22846928
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21621094
125P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21105728
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.20669049
127SOX2_18692474_ChIP-Seq_MEFs_Mouse1.20340119
128RUNX_20019798_ChIP-Seq_JUKART_Human1.20174653
129SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.19962802
130NANOG_18692474_ChIP-Seq_MESCs_Mouse1.19169758
131NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19083390
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18812946
133LXR_22292898_ChIP-Seq_THP-1_Human1.18465859
134VDR_24763502_ChIP-Seq_THP-1_Human1.18311046
135BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18297660
136TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18172723
137ESR1_15608294_ChIP-ChIP_MCF-7_Human1.17718696
138PKCTHETA_26484144_Chip-Seq_BREAST_Human1.17538603
139DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17262780
140ELK1_19687146_ChIP-ChIP_HELA_Human1.16750119
141NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16488940
142NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16030024
143MYC_22102868_ChIP-Seq_BL_Human1.15469739
144POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.14856843
145WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14610417
146NANOG_21062744_ChIP-ChIP_HESCs_Human1.14268804
147FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13161041
148POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11588765
149* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.11288411
150CLOCK_20551151_ChIP-Seq_293T_Human1.10572858
151KAP1_27257070_Chip-Seq_ESCs_Mouse1.10546810
152ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09241217
153NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08976197
154VDR_24787735_ChIP-Seq_THP-1_Human1.08581084
155RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07853917
156UBF1/2_26484160_Chip-Seq_HMECs_Human1.07754129
157EZH2_22144423_ChIP-Seq_EOC_Human1.07443722
158SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07412593
159PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.06982822
160SOX2_16153702_ChIP-ChIP_HESCs_Human1.06854905
161CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04369854
162KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03872890
163THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.03244538
164* NANOG_16518401_ChIP-PET_MESCs_Mouse1.03235628
165* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02617656
166KDM5A_27292631_Chip-Seq_BREAST_Human1.01990081
167GABP_19822575_ChIP-Seq_HepG2_Human0.99992301
168CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99981818
169SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99403545
170GATA1_19941827_ChIP-Seq_MEL_Mouse0.98551329
171NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97523553
172OCT4_18692474_ChIP-Seq_MEFs_Mouse0.96434255
173CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94918880
174* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.94810394
175* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94354643
176FOXO3_23340844_ChIP-Seq_DLD1_Human0.94151099
177E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92679578
178ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92196527
179GATA3_24758297_ChIP-Seq_MCF-7_Human0.91650273
180CREB1_26743006_Chip-Seq_LNCaP_Human0.91421472
181RARB_27405468_Chip-Seq_BRAIN_Mouse0.91258224
182RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90987033
183ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90700099
184JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89925088
185FOXM1_26456572_ChIP-Seq_MCF-7_Human0.89677170
186TBX20_22080862_ChIP-Seq_HEART_Mouse0.89660781
187TBX20_22328084_ChIP-Seq_HEART_Mouse0.89660781
188KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89415198
189DCP1A_22483619_ChIP-Seq_HELA_Human0.88981913
190CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88899088
191BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87037867
192TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.86652977
193SMAD_19615063_ChIP-ChIP_OVARY_Human0.84579328
194STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.84413454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting5.45250092
2MP0008877_abnormal_DNA_methylation4.90206441
3MP0003303_peritoneal_inflammation3.45241235
4MP0008789_abnormal_olfactory_epithelium3.33015888
5MP0005058_abnormal_lysosome_morphology3.27148738
6MP0008057_abnormal_DNA_replication3.21009077
7MP0005499_abnormal_olfactory_system3.17263620
8MP0005394_taste/olfaction_phenotype3.17263620
9MP0010094_abnormal_chromosome_stability3.02115869
10MP0004510_myositis2.94431640
11MP0003121_genomic_imprinting2.83792819
12MP0008058_abnormal_DNA_repair2.68370326
13MP0008004_abnormal_stomach_pH2.64916618
14MP0003705_abnormal_hypodermis_morpholog2.42773034
15MP0003300_gastrointestinal_ulcer2.40852578
16MP0004133_heterotaxia2.39727793
17MP0010368_abnormal_lymphatic_system2.37387160
18MP0004957_abnormal_blastocyst_morpholog2.35691836
19MP0009840_abnormal_foam_cell2.32542844
20MP0003724_increased_susceptibility_to2.32052059
21MP0003123_paternal_imprinting2.31418298
22MP0005167_abnormal_blood-brain_barrier2.24156224
23MP0003136_yellow_coat_color2.16626770
24MP0003091_abnormal_cell_migration2.14202885
25MP0003693_abnormal_embryo_hatching2.13737289
26MP0005645_abnormal_hypothalamus_physiol2.09427264
27MP0003111_abnormal_nucleus_morphology2.08464932
28MP0004233_abnormal_muscle_weight2.01188361
29MP0010234_abnormal_vibrissa_follicle2.00816873
30MP0003077_abnormal_cell_cycle2.00756295
31MP0003806_abnormal_nucleotide_metabolis1.88630734
32MP0006292_abnormal_olfactory_placode1.85742054
33MP0005451_abnormal_body_composition1.85673828
34MP0004947_skin_inflammation1.83292852
35MP0003191_abnormal_cellular_cholesterol1.79667391
36MP0004808_abnormal_hematopoietic_stem1.76786010
37MP0005409_darkened_coat_color1.69892748
38MP0003453_abnormal_keratinocyte_physiol1.65833841
39MP0003436_decreased_susceptibility_to1.64375095
40MP0003566_abnormal_cell_adhesion1.63945375
41MP0002332_abnormal_exercise_endurance1.63701049
42MP0001293_anophthalmia1.63208089
43MP0003329_amyloid_beta_deposits1.62784798
44MP0002998_abnormal_bone_remodeling1.55471673
45MP0003075_altered_response_to1.54334641
46MP0001485_abnormal_pinna_reflex1.52694514
47MP0009780_abnormal_chondrocyte_physiolo1.52170725
48MP0005310_abnormal_salivary_gland1.51060024
49MP0003828_pulmonary_edema1.51018973
50MP0010155_abnormal_intestine_physiology1.49455753
51MP0000350_abnormal_cell_proliferation1.49165790
52MP0006276_abnormal_autonomic_nervous1.47803908
53MP0001188_hyperpigmentation1.43191619
54MP0008007_abnormal_cellular_replicative1.42902117
55MP0000465_gastrointestinal_hemorrhage1.40880445
56MP0002653_abnormal_ependyma_morphology1.40380579
57MP0008932_abnormal_embryonic_tissue1.39891356
58MP0005000_abnormal_immune_tolerance1.38007691
59MP0010352_gastrointestinal_tract_polyps1.35651461
60MP0003172_abnormal_lysosome_physiology1.34596979
61MP0003045_fibrosis1.33763134
62MP0003448_altered_tumor_morphology1.33527605
63MP0005647_abnormal_sex_gland1.33040854
64MP0002148_abnormal_hypersensitivity_rea1.31349478
65MP0001879_abnormal_lymphatic_vessel1.30423992
66MP0002160_abnormal_reproductive_system1.28610346
67MP0003183_abnormal_peptide_metabolism1.28358283
68MP0003763_abnormal_thymus_physiology1.27579083
69MP0002184_abnormal_innervation1.27546301
70MP0001730_embryonic_growth_arrest1.24859674
71MP0009046_muscle_twitch1.24526807
72MP0000604_amyloidosis1.24030633
73MP0003786_premature_aging1.22345301
74MP0001835_abnormal_antigen_presentation1.22130396
75MP0002084_abnormal_developmental_patter1.22041591
76MP0002085_abnormal_embryonic_tissue1.21511928
77MP0001501_abnormal_sleep_pattern1.20923272
78MP0008874_decreased_physiological_sensi1.19736179
79MP0000767_abnormal_smooth_muscle1.19123600
80MP0002009_preneoplasia1.18239422
81MP0001873_stomach_inflammation1.16948112
82MP0001672_abnormal_embryogenesis/_devel1.16552048
83MP0005380_embryogenesis_phenotype1.16552048
84MP0003718_maternal_effect1.16235893
85MP0002210_abnormal_sex_determination1.16213831
86MP0002751_abnormal_autonomic_nervous1.14707397
87MP0003315_abnormal_perineum_morphology1.14172783
88MP0010678_abnormal_skin_adnexa1.14121967
89MP0004142_abnormal_muscle_tone1.13090429
90MP0003119_abnormal_digestive_system1.12829490
91MP0005075_abnormal_melanosome_morpholog1.11302596
92MP0004197_abnormal_fetal_growth/weight/1.11102177
93MP0002419_abnormal_innate_immunity1.10651205
94MP0001348_abnormal_lacrimal_gland1.10513211
95MP0010307_abnormal_tumor_latency1.10506372
96MP0001533_abnormal_skeleton_physiology1.10326932
97MP0006082_CNS_inflammation1.07094979
98MP0009785_altered_susceptibility_to1.06090874
99MP0003861_abnormal_nervous_system1.05716510
100MP0001542_abnormal_bone_strength1.03481349
101MP0005377_hearing/vestibular/ear_phenot1.02432772
102MP0003878_abnormal_ear_physiology1.02432772
103MP0001697_abnormal_embryo_size1.01746279
104MP0005166_decreased_susceptibility_to1.00323235
105MP0005367_renal/urinary_system_phenotyp1.00093483
106MP0000516_abnormal_urinary_system1.00093483
107MP0000383_abnormal_hair_follicle0.99998934
108MP0002166_altered_tumor_susceptibility0.99708850
109MP0005464_abnormal_platelet_physiology0.98903063
110MP0000343_altered_response_to0.98617436
111MP0005595_abnormal_vascular_smooth0.98616916
112MP0002088_abnormal_embryonic_growth/wei0.98024485
113MP0000490_abnormal_crypts_of0.97552142
114MP0009115_abnormal_fat_cell0.97379846
115MP0000627_abnormal_mammary_gland0.97189234
116MP0000920_abnormal_myelination0.96587224
117MP0004264_abnormal_extraembryonic_tissu0.96465878
118MP0005025_abnormal_response_to0.96278265
119MP0003984_embryonic_growth_retardation0.95591792
120MP0004270_analgesia0.95503576
121MP0004859_abnormal_synaptic_plasticity0.95263280
122MP0002396_abnormal_hematopoietic_system0.95141875
123MP0001145_abnormal_male_reproductive0.94816397
124MP0003690_abnormal_glial_cell0.94274445
125MP0001486_abnormal_startle_reflex0.94229548
126MP0003122_maternal_imprinting0.93721221
127MP0002086_abnormal_extraembryonic_tissu0.93615756
128MP0005623_abnormal_meninges_morphology0.93061517
129MP0005076_abnormal_cell_differentiation0.92735868
130MP0003890_abnormal_embryonic-extraembry0.92611039
131MP0002877_abnormal_melanocyte_morpholog0.92216042
132MP0003279_aneurysm0.91675521
133MP0000733_abnormal_muscle_development0.90034773
134MP0006054_spinal_hemorrhage0.89321513
135MP0002080_prenatal_lethality0.88806002
136MP0001919_abnormal_reproductive_system0.87990819
137MP0001849_ear_inflammation0.87493073
138MP0005375_adipose_tissue_phenotype0.86967148
139MP0002896_abnormal_bone_mineralization0.86779683
140MP0004185_abnormal_adipocyte_glucose0.86647877
141MP0005621_abnormal_cell_physiology0.86320017
142MP0005410_abnormal_fertilization0.85695361
143MP0002272_abnormal_nervous_system0.85246151
144MP0002723_abnormal_immune_serum0.84284009
145MP0005389_reproductive_system_phenotype0.84135561
146MP0009278_abnormal_bone_marrow0.83638163
147MP0009764_decreased_sensitivity_to0.82550686
148MP0000569_abnormal_digit_pigmentation0.82165191
149MP0000778_abnormal_nervous_system0.81398003
150MP0000371_diluted_coat_color0.81007916
151MP0000653_abnormal_sex_gland0.80722557
152MP0002796_impaired_skin_barrier0.80032031
153MP0001929_abnormal_gametogenesis0.79810814
154MP0000703_abnormal_thymus_morphology0.79156637
155MP0003879_abnormal_hair_cell0.78851004
156MP0002233_abnormal_nose_morphology0.78629846
157MP0001286_abnormal_eye_development0.78328924
158MP0000313_abnormal_cell_death0.77372129
159MP0003633_abnormal_nervous_system0.77101543
160MP0005165_increased_susceptibility_to0.76717583
161MP0000003_abnormal_adipose_tissue0.76650496
162MP0009703_decreased_birth_body0.76635728
163MP0003868_abnormal_feces_composition0.76265472
164MP0008260_abnormal_autophagy0.76119270
165MP0002452_abnormal_antigen_presenting0.75508423
166MP0001963_abnormal_hearing_physiology0.75498869
167MP0001851_eye_inflammation0.74362723
168MP0005174_abnormal_tail_pigmentation0.74343841
169MP0003698_abnormal_male_reproductive0.74256312
170MP0003635_abnormal_synaptic_transmissio0.73708748
171MP0003880_abnormal_central_pattern0.73602036
172MP0005666_abnormal_adipose_tissue0.73533148
173MP0001819_abnormal_immune_cell0.73289267
174MP0001845_abnormal_inflammatory_respons0.72777370
175MP0002420_abnormal_adaptive_immunity0.72766737
176MP0001790_abnormal_immune_system0.72704571
177MP0002152_abnormal_brain_morphology0.72389485
178MP0003941_abnormal_skin_development0.72184868
179MP0002572_abnormal_emotion/affect_behav0.69672847
180MP0000015_abnormal_ear_pigmentation0.67152982
181MP0009745_abnormal_behavioral_response0.64353759
182MP0002398_abnormal_bone_marrow0.62793650
183MP0002081_perinatal_lethality0.61946129
184MP0002882_abnormal_neuron_morphology0.61852055
185MP0005187_abnormal_penis_morphology0.61146950
186MP0002734_abnormal_mechanical_nocicepti0.61100536
187MP0009333_abnormal_splenocyte_physiolog0.61069553
188MP0002752_abnormal_somatic_nervous0.60854380

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.99092019
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68343852
3Pelvic girdle muscle weakness (HP:0003749)3.64783010
4Chromsome breakage (HP:0040012)3.62479265
5Patellar aplasia (HP:0006443)3.55299954
6Birth length less than 3rd percentile (HP:0003561)3.53630693
7Aplasia/Hypoplasia of the patella (HP:0006498)3.48832565
8Neoplasm of the oral cavity (HP:0100649)3.44361317
9Abnormality of the lower motor neuron (HP:0002366)3.35130680
10Supernumerary spleens (HP:0009799)3.23887114
11Abnormality of the hip-girdle musculature (HP:0001445)3.15010587
12Abnormality of the musculature of the pelvis (HP:0001469)3.15010587
13Dysostosis multiplex (HP:0000943)3.09197117
14J-shaped sella turcica (HP:0002680)2.96214683
15Absent radius (HP:0003974)2.94780429
16Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.94546265
17Breast hypoplasia (HP:0003187)2.92830718
18Abnormality of liposaccharide metabolism (HP:0010968)2.92082591
19Abnormality of glycosphingolipid metabolism (HP:0004343)2.92082591
20Abnormality of glycolipid metabolism (HP:0010969)2.92082591
21Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.91114696
22Supernumerary bones of the axial skeleton (HP:0009144)2.90003042
23Neurofibrillary tangles (HP:0002185)2.89860496
24Ependymoma (HP:0002888)2.87700115
25Supernumerary ribs (HP:0005815)2.85868487
26Agnosia (HP:0010524)2.81995418
27Absent frontal sinuses (HP:0002688)2.80612608
28Broad face (HP:0000283)2.75956605
29Medulloblastoma (HP:0002885)2.75699964
30Absent forearm bone (HP:0003953)2.74935245
31Aplasia involving forearm bones (HP:0009822)2.74935245
32Febrile seizures (HP:0002373)2.74694956
33Cerebral inclusion bodies (HP:0100314)2.72644454
34Impulsivity (HP:0100710)2.70884666
35Mucopolysacchariduria (HP:0008155)2.70610151
36Urinary glycosaminoglycan excretion (HP:0003541)2.70610151
37Rectovaginal fistula (HP:0000143)2.67663273
38Rectal fistula (HP:0100590)2.67663273
39Deformed sella turcica (HP:0002681)2.67396651
40Neuronal loss in central nervous system (HP:0002529)2.66904090
41Asymmetry of the thorax (HP:0001555)2.65025579
42Cerebral aneurysm (HP:0004944)2.64883493
43Syringomyelia (HP:0003396)2.61920656
44Spinal cord lesions (HP:0100561)2.61920656
45Increased cerebral lipofuscin (HP:0011813)2.60845756
46Abnormality of the ileum (HP:0001549)2.60175475
47Intestinal fistula (HP:0100819)2.57829846
48Meckel diverticulum (HP:0002245)2.57722675
49Abnormality of polysaccharide metabolism (HP:0011012)2.55549804
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.55549804
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.55549804
52Esophageal varix (HP:0002040)2.51235017
53Aplasia/Hypoplasia of the uvula (HP:0010293)2.48736565
54Atonic seizures (HP:0010819)2.46848061
55Abnormal number of incisors (HP:0011064)2.46599814
56Tongue fasciculations (HP:0001308)2.43538909
57Macroorchidism (HP:0000053)2.42029315
58Apathy (HP:0000741)2.41215757
59Abnormality of the frontal sinuses (HP:0002687)2.39137022
60Aplasia/hypoplasia of the humerus (HP:0006507)2.38174521
61Rib fusion (HP:0000902)2.37773655
62Absent thumb (HP:0009777)2.33789250
63Carpal bone hypoplasia (HP:0001498)2.33583986
64Abnormality of chromosome stability (HP:0003220)2.33424295
65Thin bony cortex (HP:0002753)2.33157942
66Thoracolumbar scoliosis (HP:0002944)2.32174624
67Hypothermia (HP:0002045)2.31206943
68Loss of speech (HP:0002371)2.30678918
69Thoracic kyphosis (HP:0002942)2.30553184
70Abnormality of the preputium (HP:0100587)2.30467778
71Abnormality of the anterior horn cell (HP:0006802)2.27877220
72Degeneration of anterior horn cells (HP:0002398)2.27877220
73Supranuclear gaze palsy (HP:0000605)2.27757819
74Amaurosis fugax (HP:0100576)2.27248694
75Short nail (HP:0001799)2.27034624
76Resting tremor (HP:0002322)2.24805790
77Astrocytoma (HP:0009592)2.23525563
78Abnormality of the astrocytes (HP:0100707)2.23525563
79Dysmetric saccades (HP:0000641)2.23134558
80Diminished motivation (HP:0000745)2.23121110
81Abnormality of the thoracic spine (HP:0100711)2.22859715
82Palpebral edema (HP:0100540)2.22819198
83Short humerus (HP:0005792)2.22167778
84Breast aplasia (HP:0100783)2.21949139
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.20111523
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.17896628
87Osteolytic defects of the hand bones (HP:0009699)2.17896628
88Hyperparathyroidism (HP:0000843)2.17755356
89Germ cell neoplasia (HP:0100728)2.16105007
90Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14127602
91Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.13996926
92Mask-like facies (HP:0000298)2.13802492
93Cerebral hypomyelination (HP:0006808)2.12578550
94Overgrowth (HP:0001548)2.12291778
95Tetraparesis (HP:0002273)2.11844206
96Facial cleft (HP:0002006)2.11537560
97Colitis (HP:0002583)2.11050872
98Abnormality of the periventricular white matter (HP:0002518)2.08901669
99Deep philtrum (HP:0002002)2.08344558
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.07743412
101Vaginal fistula (HP:0004320)2.06796993
102Muscle fibrillation (HP:0010546)2.06630049
103Flat acetabular roof (HP:0003180)2.06352949
104Median cleft lip (HP:0000161)2.04816354
105Absent hand (HP:0004050)2.04445134
106Embryonal renal neoplasm (HP:0011794)2.04142703
107Spontaneous hematomas (HP:0007420)2.03844877
108Ectopic kidney (HP:0000086)2.00668805
109Mutism (HP:0002300)2.00580488
110Abnormality of lateral ventricle (HP:0030047)1.98480423
111Interstitial pulmonary disease (HP:0006530)1.97987242
112Action tremor (HP:0002345)1.97276541
113Truncal ataxia (HP:0002078)1.96714503
114Decreased testicular size (HP:0008734)1.95682384
115Micronodular cirrhosis (HP:0001413)1.95384038
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94597125
117Hyperacusis (HP:0010780)1.94424042
118Rhabdomyosarcoma (HP:0002859)1.93087922
119Aortic aneurysm (HP:0004942)1.92225646
120Sloping forehead (HP:0000340)1.91528544
121Spinal muscular atrophy (HP:0007269)1.90642890
122Cystic hygroma (HP:0000476)1.90278550
123Progressive cerebellar ataxia (HP:0002073)1.89467561
124Obstructive sleep apnea (HP:0002870)1.87462487
125Missing ribs (HP:0000921)1.87287394
126Disinhibition (HP:0000734)1.86852247
127Stroke (HP:0001297)1.86606145
128Capillary hemangiomas (HP:0005306)1.86030244
129Aplasia/Hypoplasia of the breasts (HP:0010311)1.85802177
130Hematochezia (HP:0002573)1.84670816
131Basal cell carcinoma (HP:0002671)1.83705356
132Abnormality of the distal phalanx of the thumb (HP:0009617)1.83630013
133Abnormality of the sella turcica (HP:0002679)1.83559489
134Nephroblastoma (Wilms tumor) (HP:0002667)1.83526037
135Medial flaring of the eyebrow (HP:0010747)1.82404238
136Duplicated collecting system (HP:0000081)1.81638600
137Gaze-evoked nystagmus (HP:0000640)1.81579381
138Glioma (HP:0009733)1.80103298
139Gait imbalance (HP:0002141)1.78787607
140Abnormality of oral frenula (HP:0000190)1.77076743
141Gastroesophageal reflux (HP:0002020)1.76536573
142Urinary bladder sphincter dysfunction (HP:0002839)1.76500609
143Generalized hypopigmentation of hair (HP:0011358)1.76387275
144Insidious onset (HP:0003587)1.76282858
145Termporal pattern (HP:0011008)1.76282858
146Adrenal hypoplasia (HP:0000835)1.75835372
147Volvulus (HP:0002580)1.75563119
148Delayed puberty (HP:0000823)1.75478109
149Congenital primary aphakia (HP:0007707)1.75464743
150Orchitis (HP:0100796)1.75232718
151Cubitus valgus (HP:0002967)1.74630051
152Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.74506954
153Slow saccadic eye movements (HP:0000514)1.73833165
154Atrophy/Degeneration involving motor neurons (HP:0007373)1.73544540
155Optic neuritis (HP:0100653)1.73079477
156Retrobulbar optic neuritis (HP:0100654)1.73079477
157Hyporeflexia of lower limbs (HP:0002600)1.72445575
158Sex reversal (HP:0012245)1.72145549
159Abnormal sex determination (HP:0012244)1.72145549
160Myelodysplasia (HP:0002863)1.69707822
161Buphthalmos (HP:0000557)1.69494573
162Coxa valga (HP:0002673)1.69148948
163Ankle clonus (HP:0011448)1.68495032
164Ankyloglossia (HP:0010296)1.68465621
165Spondylolisthesis (HP:0003302)1.68419249
166Spinal cord compression (HP:0002176)1.68351367
167Abnormality of the lumbar spine (HP:0100712)1.68286522
168Hypercortisolism (HP:0001578)1.67925034
169Spastic gait (HP:0002064)1.67764833
170Long toe (HP:0010511)1.67368082
171Micropenis (HP:0000054)1.67267163
172Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66629360
173Neoplasm of striated muscle (HP:0009728)1.64772580
174Poor coordination (HP:0002370)1.64479394
175Abnormality of the labia (HP:0000058)1.64381507
176Small intestinal stenosis (HP:0012848)1.63105290
177Duodenal stenosis (HP:0100867)1.63105290
178Abdominal distention (HP:0003270)1.62760158
179Abnormality of the columella (HP:0009929)1.62731997
180Premature graying of hair (HP:0002216)1.62161323
181Sparse lateral eyebrow (HP:0005338)1.61692838
182Relative macrocephaly (HP:0004482)1.61622463
183Nephrogenic diabetes insipidus (HP:0009806)1.61431581
184Pancreatic fibrosis (HP:0100732)1.60826238
185Selective tooth agenesis (HP:0001592)1.60683349
186Prominent nose (HP:0000448)1.60423883
187Inappropriate behavior (HP:0000719)1.59865282
188Bone marrow hypocellularity (HP:0005528)1.59711755
189Arterial tortuosity (HP:0005116)1.59501333
190Subacute progressive viral hepatitis (HP:0006572)1.58485145
191Axonal loss (HP:0003447)1.58101554
192Nuclear cataract (HP:0100018)1.57290163
193Abnormality of the vasculature of the conjunctiva (HP:0008054)1.56901501
194Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.56585202
195Coarse hair (HP:0002208)1.55995890
196Type I transferrin isoform profile (HP:0003642)1.55411756
197Absence seizures (HP:0002121)1.55402225
198Mitral stenosis (HP:0001718)1.55145100
199Aneurysm (HP:0002617)1.55028988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMPR24.42071689
2ERBB34.30104762
3AKT33.56962084
4PNCK3.50331762
5TRIB33.31020329
6IRAK33.27168643
7CASK3.06884672
8SRPK12.86156802
9TSSK62.69593003
10PLK42.62638907
11CDK122.32378031
12ICK2.29679661
13STK162.27299850
14TIE12.18397371
15EPHA22.16886671
16PRKD32.14150687
17RIPK12.12973423
18TAOK22.05936117
19WEE12.03054434
20EEF2K1.98758529
21CDC71.98324800
22MAP3K131.97438494
23MKNK21.90487533
24SCYL21.89334274
25MAP3K141.85308975
26NEK61.82180284
27MAP2K71.70305062
28BUB11.67479335
29RIPK41.64750765
30SIK21.64483502
31MKNK11.58004014
32SIK31.55988802
33PLK11.50952916
34PKN21.48233906
35PDGFRA1.46364578
36NTRK31.45899039
37EIF2AK11.45679771
38PLK31.43381131
39PDPK11.41487851
40PIK3CA1.40865962
41NEK11.38518833
42TLK11.32921100
43TTK1.29549243
44CHEK21.28317993
45CAMKK11.27117727
46SIK11.25668702
47STK381.25044099
48PDK11.24674947
49CAMK1D1.24333801
50CAMK1G1.22469094
51NME21.19948696
52DAPK11.19912546
53MAP3K41.19349988
54PDGFRB1.16002195
55AURKA1.14911360
56JAK11.14586395
57PIM11.13771083
58NEK21.11151986
59TGFBR21.10797538
60PINK11.09220520
61ARAF1.09044082
62KSR21.08077627
63MARK21.07899747
64RPS6KA21.05960792
65SGK31.05523747
66BRD41.05127677
67PRPF4B1.04886088
68ALK1.04713835
69CDK191.04620393
70SGK2231.03578984
71SGK4941.03578984
72CAMKK21.00857170
73RET1.00493301
74CHEK10.99044233
75MTOR0.98668731
76CSNK1G30.97536413
77MAP3K10.96855883
78NTRK20.96566732
79CSNK1G20.96564497
80DAPK20.96037204
81PDK20.94976452
82NUAK10.93165606
83FES0.93163690
84IKBKE0.90965381
85TXK0.90659333
86EIF2AK30.89563299
87CHUK0.89073696
88RPS6KB20.85694785
89TBK10.82109663
90YES10.80283239
91CDK70.79799880
92MELK0.78062194
93STK240.77986469
94MAP3K120.77948045
95CDK20.77621846
96PAK60.77369370
97MOS0.76991927
98ATR0.76302633
99MAPK150.75959224
100ACVR1B0.75726233
101TYRO30.74845600
102VRK10.74522803
103STK38L0.73214257
104CDK40.72426621
105CDK30.71380954
106MAP2K30.70861666
107WNK30.67504102
108DYRK30.66065136
109CSNK1G10.65486900
110PTK20.64768078
111MAPK120.64698084
112TAOK10.64205692
113FER0.63691002
114IRAK20.63110564
115PLK20.62835702
116ATM0.62442325
117CDC42BPA0.62225952
118MAPKAPK30.61995154
119MAP3K110.61836890
120CSNK1D0.61561008
121STK110.61449582
122JAK20.61229664
123CSNK1A1L0.61143010
124GRK60.61112287
125DYRK20.61035647
126ZAP700.60842137
127TTN0.60734343
128DYRK1A0.60683378
129DDR20.60617390
130PRKCI0.57962034
131CDK60.57861773
132AURKB0.57690705
133HIPK20.56012374
134CSNK2A20.55768693
135RAF10.55095717
136KDR0.55019309
137PRKD20.54937570
138TRPM70.54013808
139PAK20.53908320
140PIM20.52458723
141IKBKB0.52305514
142MAP3K90.52177619
143CAMK40.51919893
144CCNB10.50664877
145CDK10.48957388
146MAPK110.48546531
147ZAK0.48429488
148CSNK1E0.47758736
149SMG10.46830827
150MARK30.46728811
151PRKCG0.45817563
152ERN10.44966350
153MST40.43999551
154SGK20.43782148
155MAP3K30.43337799
156BLK0.42108793
157MINK10.40505454
158PRKCH0.39583864
159RPS6KC10.39139438
160RPS6KL10.39139438
161CSK0.39112863
162BCR0.38701294
163PRKG20.37378373
164CSNK2A10.37135417
165CAMK10.36965952
166BTK0.36383794
167FGFR30.35481741
168STK390.35380596
169GSK3B0.35260740
170CAMK2B0.34824607
171HCK0.33774100
172CDK90.33538624
173STK40.32871538
174PASK0.32455497
175CDK140.31718077
176EIF2AK20.31711272
177CDK180.30034013
178TNK20.29101403
179MAPK140.28698747
180UHMK10.27532858
181CDK150.27301898
182LATS20.26155286
183RPS6KB10.26053734
184PDK30.25831228
185PDK40.25831228
186MAPK100.25508889

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.43718386
2Mismatch repair_Homo sapiens_hsa034303.32218380
3DNA replication_Homo sapiens_hsa030303.18319812
4Non-homologous end-joining_Homo sapiens_hsa034502.95955851
5RNA transport_Homo sapiens_hsa030132.61726319
6RNA polymerase_Homo sapiens_hsa030202.57547389
7Spliceosome_Homo sapiens_hsa030402.47721827
8Nucleotide excision repair_Homo sapiens_hsa034202.29872580
9Homologous recombination_Homo sapiens_hsa034402.23829721
10Fanconi anemia pathway_Homo sapiens_hsa034602.22248805
11mRNA surveillance pathway_Homo sapiens_hsa030152.19431578
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14398525
13Proteasome_Homo sapiens_hsa030501.95218105
14Cell cycle_Homo sapiens_hsa041101.94629251
15Base excision repair_Homo sapiens_hsa034101.83514002
16Basal transcription factors_Homo sapiens_hsa030221.76973417
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.61751179
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.61627158
19VEGF signaling pathway_Homo sapiens_hsa043701.59440911
20RNA degradation_Homo sapiens_hsa030181.52629370
21Olfactory transduction_Homo sapiens_hsa047401.50427970
22TNF signaling pathway_Homo sapiens_hsa046681.49230003
23Ribosome_Homo sapiens_hsa030101.49227444
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45691453
25Synaptic vesicle cycle_Homo sapiens_hsa047211.44581337
26Osteoclast differentiation_Homo sapiens_hsa043801.43550717
27Acute myeloid leukemia_Homo sapiens_hsa052211.41067729
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.37682657
29Endometrial cancer_Homo sapiens_hsa052131.34638224
30B cell receptor signaling pathway_Homo sapiens_hsa046621.34304923
31Epstein-Barr virus infection_Homo sapiens_hsa051691.32353896
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.31824510
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30978488
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30880182
35Prolactin signaling pathway_Homo sapiens_hsa049171.30609696
36Renal cell carcinoma_Homo sapiens_hsa052111.29354033
37Glioma_Homo sapiens_hsa052141.27296309
38Oocyte meiosis_Homo sapiens_hsa041141.26247455
39Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24354915
40Nicotine addiction_Homo sapiens_hsa050331.23935033
41Non-small cell lung cancer_Homo sapiens_hsa052231.22428661
42Dorso-ventral axis formation_Homo sapiens_hsa043201.21429025
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21181264
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.19072485
45p53 signaling pathway_Homo sapiens_hsa041151.18291090
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.18223630
47Bladder cancer_Homo sapiens_hsa052191.18223226
48Pyrimidine metabolism_Homo sapiens_hsa002401.17621100
49One carbon pool by folate_Homo sapiens_hsa006701.17421100
50Estrogen signaling pathway_Homo sapiens_hsa049151.16878747
51Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.15970042
52Sphingolipid signaling pathway_Homo sapiens_hsa040711.15589612
53Alcoholism_Homo sapiens_hsa050341.14259416
54Hepatitis C_Homo sapiens_hsa051601.13675277
55Pancreatic cancer_Homo sapiens_hsa052121.12968810
56Lysosome_Homo sapiens_hsa041421.12498447
57Phospholipase D signaling pathway_Homo sapiens_hsa040721.09413797
58Viral carcinogenesis_Homo sapiens_hsa052031.08944157
59Amoebiasis_Homo sapiens_hsa051461.07476288
60Serotonergic synapse_Homo sapiens_hsa047261.05078854
61Gap junction_Homo sapiens_hsa045401.04184298
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.02914128
63Other glycan degradation_Homo sapiens_hsa005111.02684834
64Collecting duct acid secretion_Homo sapiens_hsa049661.02635479
65Type II diabetes mellitus_Homo sapiens_hsa049301.01344155
66Jak-STAT signaling pathway_Homo sapiens_hsa046301.00770429
67GnRH signaling pathway_Homo sapiens_hsa049121.00653761
68Platelet activation_Homo sapiens_hsa046110.99375305
69Proteoglycans in cancer_Homo sapiens_hsa052050.98399740
70Toxoplasmosis_Homo sapiens_hsa051450.97706516
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.97487724
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97362926
73Choline metabolism in cancer_Homo sapiens_hsa052310.97322174
74Ovarian steroidogenesis_Homo sapiens_hsa049130.96107361
75Malaria_Homo sapiens_hsa051440.95091007
76Influenza A_Homo sapiens_hsa051640.94674209
77Salmonella infection_Homo sapiens_hsa051320.93533066
78Small cell lung cancer_Homo sapiens_hsa052220.93147260
79Regulation of autophagy_Homo sapiens_hsa041400.92628593
80Colorectal cancer_Homo sapiens_hsa052100.92505408
81Amphetamine addiction_Homo sapiens_hsa050310.92499712
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92091430
83Systemic lupus erythematosus_Homo sapiens_hsa053220.91050502
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.90923762
85Taste transduction_Homo sapiens_hsa047420.90496645
86Prion diseases_Homo sapiens_hsa050200.89304031
87Endocytosis_Homo sapiens_hsa041440.88329405
88Primary immunodeficiency_Homo sapiens_hsa053400.87920512
89Insulin resistance_Homo sapiens_hsa049310.87740566
90HIF-1 signaling pathway_Homo sapiens_hsa040660.87602333
91Measles_Homo sapiens_hsa051620.87307808
92Chemokine signaling pathway_Homo sapiens_hsa040620.87041782
93Tuberculosis_Homo sapiens_hsa051520.85999622
94Purine metabolism_Homo sapiens_hsa002300.84842034
95Focal adhesion_Homo sapiens_hsa045100.83997271
96Fatty acid biosynthesis_Homo sapiens_hsa000610.83659744
97Leishmaniasis_Homo sapiens_hsa051400.82549923
98Notch signaling pathway_Homo sapiens_hsa043300.82353004
99T cell receptor signaling pathway_Homo sapiens_hsa046600.81051943
100Antigen processing and presentation_Homo sapiens_hsa046120.79157576
101Dopaminergic synapse_Homo sapiens_hsa047280.78324641
102Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.78190718
103Leukocyte transendothelial migration_Homo sapiens_hsa046700.77137461
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75618255
105Long-term potentiation_Homo sapiens_hsa047200.75544039
106Oxytocin signaling pathway_Homo sapiens_hsa049210.74449599
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74211519
108Insulin signaling pathway_Homo sapiens_hsa049100.72553224
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71206017
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.71040024
111Legionellosis_Homo sapiens_hsa051340.70983764
112TGF-beta signaling pathway_Homo sapiens_hsa043500.70920591
113Herpes simplex infection_Homo sapiens_hsa051680.70131240
114Renin secretion_Homo sapiens_hsa049240.68082864
115Pertussis_Homo sapiens_hsa051330.68016388
116Rap1 signaling pathway_Homo sapiens_hsa040150.66456989
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65895766
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65875498
119AMPK signaling pathway_Homo sapiens_hsa041520.65859379
120Shigellosis_Homo sapiens_hsa051310.65150284
121Sphingolipid metabolism_Homo sapiens_hsa006000.61245562
122Morphine addiction_Homo sapiens_hsa050320.60442084
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60387775
124HTLV-I infection_Homo sapiens_hsa051660.59940639
125Rheumatoid arthritis_Homo sapiens_hsa053230.58586296
126cAMP signaling pathway_Homo sapiens_hsa040240.57683411
127mTOR signaling pathway_Homo sapiens_hsa041500.57244769
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56647778
129Huntingtons disease_Homo sapiens_hsa050160.56577118
130Type I diabetes mellitus_Homo sapiens_hsa049400.56073470
131Hippo signaling pathway_Homo sapiens_hsa043900.56048273
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55253730
133Hedgehog signaling pathway_Homo sapiens_hsa043400.54162745
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53954144
135Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53614815
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52224903
137MicroRNAs in cancer_Homo sapiens_hsa052060.51916759
138Long-term depression_Homo sapiens_hsa047300.51430551
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.51090058
140GABAergic synapse_Homo sapiens_hsa047270.50304266
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48812200
142Graft-versus-host disease_Homo sapiens_hsa053320.48312984
143Adherens junction_Homo sapiens_hsa045200.47621126
144Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47529643
145NOD-like receptor signaling pathway_Homo sapiens_hsa046210.46977636
146ErbB signaling pathway_Homo sapiens_hsa040120.46775137
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46680639
148FoxO signaling pathway_Homo sapiens_hsa040680.46549051
149Vibrio cholerae infection_Homo sapiens_hsa051100.45971843
150Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45954340
151Allograft rejection_Homo sapiens_hsa053300.45231277
152Tight junction_Homo sapiens_hsa045300.44347008
153Pathways in cancer_Homo sapiens_hsa052000.44078012
154Cholinergic synapse_Homo sapiens_hsa047250.43869714
155MAPK signaling pathway_Homo sapiens_hsa040100.43167273
156Ras signaling pathway_Homo sapiens_hsa040140.41146012
157NF-kappa B signaling pathway_Homo sapiens_hsa040640.41137384
158Wnt signaling pathway_Homo sapiens_hsa043100.41017861
159Prostate cancer_Homo sapiens_hsa052150.40178046
160Apoptosis_Homo sapiens_hsa042100.39985637
161Autoimmune thyroid disease_Homo sapiens_hsa053200.39610723
162Inositol phosphate metabolism_Homo sapiens_hsa005620.38903797
163Glutamatergic synapse_Homo sapiens_hsa047240.38415585
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38086129
165Thyroid cancer_Homo sapiens_hsa052160.37804184
166Hepatitis B_Homo sapiens_hsa051610.37736800
167Chronic myeloid leukemia_Homo sapiens_hsa052200.37413890
168RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.36137667
169Viral myocarditis_Homo sapiens_hsa054160.34755127
170Circadian entrainment_Homo sapiens_hsa047130.32136732
171Melanoma_Homo sapiens_hsa052180.31005205

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