CDX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal epithelial cell development (GO:0060576)8.10377013
2regulation of guanylate cyclase activity (GO:0031282)7.44236715
3interferon-gamma secretion (GO:0072643)7.30381127
4intestinal absorption (GO:0050892)6.29601932
5positive regulation of respiratory burst (GO:0060267)5.77199239
6positive regulation of guanylate cyclase activity (GO:0031284)5.32298898
7epoxygenase P450 pathway (GO:0019373)5.28455094
8regulation of systemic arterial blood pressure by hormone (GO:0001990)5.25425261
9regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.25425261
10endocrine process (GO:0050886)5.25425261
11modified amino acid transport (GO:0072337)5.24974726
12regulation of cellular extravasation (GO:0002691)5.20836225
13folic acid metabolic process (GO:0046655)5.11284430
14renal system process involved in regulation of blood volume (GO:0001977)5.04833320
15intestinal cholesterol absorption (GO:0030299)4.96649876
16GDP-mannose metabolic process (GO:0019673)4.91391919
17fat-soluble vitamin biosynthetic process (GO:0042362)4.90370708
18pyrimidine nucleoside salvage (GO:0043097)4.84190997
19pyrimidine-containing compound salvage (GO:0008655)4.84190997
20regulation of systemic arterial blood pressure (GO:0003073)4.76978221
21deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.75068745
22folic acid transport (GO:0015884)4.73369045
23flavonoid metabolic process (GO:0009812)4.58236154
24regulation of cGMP biosynthetic process (GO:0030826)4.52394017
25lipoprotein transport (GO:0042953)4.52297930
26nucleoside salvage (GO:0043174)4.51295420
27calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.44765977
28UDP-N-acetylglucosamine metabolic process (GO:0006047)4.40342460
29hepatocyte apoptotic process (GO:0097284)4.39555591
30glomerular filtration (GO:0003094)4.37056867
31regulation of vitamin metabolic process (GO:0030656)4.36742065
32diacylglycerol metabolic process (GO:0046339)4.34725209
33urea cycle (GO:0000050)4.30398358
34regulation of respiratory burst (GO:0060263)4.22956165
35angiotensin maturation (GO:0002003)4.21643820
36regulation of water loss via skin (GO:0033561)4.17263615
37hormone catabolic process (GO:0042447)4.16630306
38regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.14676730
39bundle of His cell to Purkinje myocyte communication (GO:0086069)4.10804132
40urea metabolic process (GO:0019627)4.05329791
41regulation of cholesterol homeostasis (GO:2000188)4.05285546
42drug metabolic process (GO:0017144)3.99856490
43galactose catabolic process (GO:0019388)3.99636642
44renal filtration (GO:0097205)3.96660699
45ethanol oxidation (GO:0006069)3.96378171
46oligosaccharide catabolic process (GO:0009313)3.95435220
47very-low-density lipoprotein particle assembly (GO:0034379)3.92608926
48desmosome organization (GO:0002934)3.88639059
49nucleotide-sugar biosynthetic process (GO:0009226)3.83513381
50actin filament depolymerization (GO:0030042)3.80305162
51regulation of cardioblast differentiation (GO:0051890)3.79283259
52oligosaccharide biosynthetic process (GO:0009312)3.79088968
53positive regulation of Cdc42 GTPase activity (GO:0043089)3.74388276
54cGMP-mediated signaling (GO:0019934)3.71381341
55nitrogen cycle metabolic process (GO:0071941)3.70729202
56establishment of skin barrier (GO:0061436)3.70661797
57ribosomal small subunit biogenesis (GO:0042274)3.69840329
58regulation of cGMP metabolic process (GO:0030823)3.69007323
59CDP-diacylglycerol metabolic process (GO:0046341)3.65353100
60adhesion of symbiont to host cell (GO:0044650)3.64387460
61virion attachment to host cell (GO:0019062)3.64387460
62positive regulation of glycoprotein biosynthetic process (GO:0010560)3.62334140
63positive regulation of pseudopodium assembly (GO:0031274)3.61312021
64renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.61211330
65purine nucleobase biosynthetic process (GO:0009113)3.58080093
66plasma lipoprotein particle assembly (GO:0034377)3.57304458
67glycosphingolipid catabolic process (GO:0046479)3.56607006
68regulation of translation in response to stress (GO:0043555)3.56048417
69vitamin transmembrane transport (GO:0035461)3.53708302
70glycolipid catabolic process (GO:0019377)3.52488976
71cell differentiation involved in embryonic placenta development (GO:0060706)3.52324800
72peptide catabolic process (GO:0043171)3.51766755
73phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.51255299
74nucleoside diphosphate biosynthetic process (GO:0009133)3.49603202
75auditory receptor cell differentiation (GO:0042491)3.49545078
76epithelial structure maintenance (GO:0010669)3.49403736
77fructose metabolic process (GO:0006000)3.46291033
78positive regulation of glycoprotein metabolic process (GO:1903020)3.42828095
79regulation of histone H3-K27 methylation (GO:0061085)3.41922538
80glucocorticoid biosynthetic process (GO:0006704)3.40401900
81ribosome assembly (GO:0042255)3.39361568
82positive regulation of fatty acid beta-oxidation (GO:0032000)3.38547849
83peptide hormone processing (GO:0016486)3.36346872
84maintenance of gastrointestinal epithelium (GO:0030277)3.36132809
85maturation of SSU-rRNA (GO:0030490)3.35062107
86regulation of pseudopodium assembly (GO:0031272)3.34684797
87transcytosis (GO:0045056)3.34236133
88heme transport (GO:0015886)3.33361335
89protein-lipid complex assembly (GO:0065005)3.32982381
90antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.31009740
91glutamine family amino acid biosynthetic process (GO:0009084)3.28823981
92fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.27933645
93DNA damage response, detection of DNA damage (GO:0042769)3.25814043
94proteasome assembly (GO:0043248)3.20895160
95sulfate transmembrane transport (GO:1902358)3.20417852
96DNA deamination (GO:0045006)3.19897098
97arginine metabolic process (GO:0006525)3.18849467
98O-glycan processing (GO:0016266)3.18624304
99vitamin A metabolic process (GO:0006776)3.17044162
100digestion (GO:0007586)3.16621003
101antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16452437
102nucleobase biosynthetic process (GO:0046112)3.15033183
103adhesion of symbiont to host (GO:0044406)3.14352620
104NADH metabolic process (GO:0006734)3.14336469
105anterior/posterior axis specification, embryo (GO:0008595)3.14177020
106tight junction assembly (GO:0070830)3.13461584
107negative regulation of keratinocyte proliferation (GO:0010839)3.10110091
108positive regulation of cGMP biosynthetic process (GO:0030828)3.06662979
109ethanol metabolic process (GO:0006067)3.06134725
110positive regulation of lipid catabolic process (GO:0050996)3.04217003
111sulfur compound transport (GO:0072348)3.03852118
112sulfate transport (GO:0008272)3.03531675
113homocysteine metabolic process (GO:0050667)3.02997877
114thrombin receptor signaling pathway (GO:0070493)3.01517213
115glucose 6-phosphate metabolic process (GO:0051156)3.01092177
116fucosylation (GO:0036065)3.00515834
117cellular glucuronidation (GO:0052695)2.98958694
118ADP metabolic process (GO:0046031)2.98448553
119digestive system process (GO:0022600)2.98048451
120formation of translation preinitiation complex (GO:0001731)2.96450714
121antigen processing and presentation of endogenous antigen (GO:0019883)2.96350761
122cellular response to nitric oxide (GO:0071732)2.95874410
123receptor guanylyl cyclase signaling pathway (GO:0007168)2.95854176
124nucleobase-containing small molecule interconversion (GO:0015949)2.95122330
125viral transcription (GO:0019083)2.94372282
126glycosylceramide metabolic process (GO:0006677)2.93587995
127sphingolipid catabolic process (GO:0030149)2.93466101
128complement activation, classical pathway (GO:0006958)2.92844510
129drug transport (GO:0015893)2.91830455
130eosinophil chemotaxis (GO:0048245)2.90586719
131mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90530922
132response to nitric oxide (GO:0071731)2.89701789
133translational termination (GO:0006415)2.88878523
134alkaloid metabolic process (GO:0009820)2.88871274
135diol metabolic process (GO:0034311)2.88487665
136sphingomyelin metabolic process (GO:0006684)2.87524586
137keratinocyte development (GO:0003334)2.86977046
138CDP-diacylglycerol biosynthetic process (GO:0016024)2.81424288
139regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.79958584
140antibacterial humoral response (GO:0019731)2.79321914
141translational initiation (GO:0006413)2.76838787
142respiratory tube development (GO:0030323)2.75983072
143negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.75586786
144establishment of protein localization to mitochondrial membrane (GO:0090151)2.75439533
145* trophectodermal cell differentiation (GO:0001829)2.74981054
146lung-associated mesenchyme development (GO:0060484)2.74304062
147regulation of cellular amino acid metabolic process (GO:0006521)2.73410431
148branching involved in labyrinthine layer morphogenesis (GO:0060670)2.73278987
149antimicrobial humoral response (GO:0019730)2.72771169
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71647656
151nucleotide-sugar metabolic process (GO:0009225)2.71626981
152regulation of gene silencing by miRNA (GO:0060964)2.71529602
153regulation of gene silencing by RNA (GO:0060966)2.71529602
154regulation of posttranscriptional gene silencing (GO:0060147)2.71529602
155regulation of bile acid biosynthetic process (GO:0070857)2.71184628
156positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.70614556
157inner cell mass cell proliferation (GO:0001833)2.69396154
158ribosomal large subunit biogenesis (GO:0042273)2.68824811
159uterus development (GO:0060065)2.68754197
160vitamin transport (GO:0051180)2.67427220
161sulfur amino acid catabolic process (GO:0000098)2.67289865
162cyclooxygenase pathway (GO:0019371)2.67023299
163columnar/cuboidal epithelial cell development (GO:0002066)2.66619899
164uronic acid metabolic process (GO:0006063)2.64112128
165glucuronate metabolic process (GO:0019585)2.64112128
166bile acid and bile salt transport (GO:0015721)2.63576418
167regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.63100052
168positive regulation of epidermal cell differentiation (GO:0045606)2.62465058
169purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.61409104
1703-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.61409104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.40505634
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.12960378
3* CDX2_20551321_ChIP-Seq_CACO-2_Human3.00288592
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88011775
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.83102938
6* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.77517114
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.75654993
8* SRY_22984422_ChIP-ChIP_TESTIS_Rat2.48484619
9AR_21909140_ChIP-Seq_LNCAP_Human2.47176386
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.43872510
11KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.41887586
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40632388
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.26016957
14* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.25169954
15* LXR_22292898_ChIP-Seq_THP-1_Human2.23266216
16ZNF263_19887448_ChIP-Seq_K562_Human2.23238881
17E2F7_22180533_ChIP-Seq_HELA_Human2.21466430
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20580512
19* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.18153346
20NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.16413901
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.15184404
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.12387017
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.07627178
24* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.06679007
25RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.06586079
26MYC_18358816_ChIP-ChIP_MESCs_Mouse2.02793512
27GATA6_25053715_ChIP-Seq_YYC3_Human1.99538211
28FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99219641
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.98911440
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.95528559
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.94448707
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.89798167
33* GATA4_25053715_ChIP-Seq_YYC3_Human1.85928444
34* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.85198465
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83781011
36* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.82458045
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.82433117
38SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.81264099
39BP1_19119308_ChIP-ChIP_Hs578T_Human1.80729640
40SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.79741668
41FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.78741836
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.76099424
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76089902
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74470593
45JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.74101273
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.72547015
47PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.72101819
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.70293926
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.70293926
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.70293926
51FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.69818636
52* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.67444441
53ATF3_27146783_Chip-Seq_COLON_Human1.66375688
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.65834203
55RACK7_27058665_Chip-Seq_MCF-7_Human1.64480409
56XRN2_22483619_ChIP-Seq_HELA_Human1.59804234
57CLOCK_20551151_ChIP-Seq_293T_Human1.54226999
58PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52778377
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.52692918
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.52538002
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.50610008
62TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.50295438
63EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.49570131
64STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48149833
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.47161681
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45239161
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44825488
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44330515
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41783163
70CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41016053
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39997775
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39888146
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.39366473
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.38808589
75BCL6_27268052_Chip-Seq_Bcells_Human1.37470587
76TRIM28_21343339_ChIP-Seq_HEK293_Human1.36952188
77PPAR_26484153_Chip-Seq_NCI-H1993_Human1.36689693
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35432766
79KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33747519
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.32787820
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.30971488
82* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.30321335
83* NANOG_18692474_ChIP-Seq_MEFs_Mouse1.30229906
84VDR_21846776_ChIP-Seq_THP-1_Human1.29756267
85SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29520385
86SOX2_20726797_ChIP-Seq_SW620_Human1.26721723
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.25552849
88P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24612555
89* SA1_27219007_Chip-Seq_Bcells_Human1.23303732
90SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22495024
91GABP_17652178_ChIP-ChIP_JURKAT_Human1.20706512
92ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19995368
93HNF4A_19822575_ChIP-Seq_HepG2_Human1.18763646
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18476147
95PHF8_20622854_ChIP-Seq_HELA_Human1.17694567
96CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17066264
97ELK3_25401928_ChIP-Seq_HUVEC_Human1.17054531
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15934845
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.15041564
100* AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14883861
101* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12651872
102CTCF_27219007_Chip-Seq_Bcells_Human1.11966742
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.11230551
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10841452
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09740126
106NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08869543
107DCP1A_22483619_ChIP-Seq_HELA_Human1.07846517
108ETS1_21867929_ChIP-Seq_TH2_Mouse1.07547335
109* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07088173
110SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06585555
111DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06168891
112FOXA1_25552417_ChIP-Seq_VCAP_Human1.05824105
113ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.03937778
114GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02850475
115TCF4_18268006_ChIP-ChIP_LS174T_Human1.02669546
116KDM5A_27292631_Chip-Seq_BREAST_Human1.02179846
117DNAJC2_21179169_ChIP-ChIP_NT2_Human1.01289987
118GABP_19822575_ChIP-Seq_HepG2_Human1.00862028
119* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00803003
120ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00761547
121TET1_21451524_ChIP-Seq_MESCs_Mouse1.00694588
122BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.00563928
123CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99513163
124TTF2_22483619_ChIP-Seq_HELA_Human0.98597899
125VDR_24763502_ChIP-Seq_THP-1_Human0.98373469
126SA1_27219007_Chip-Seq_ERYTHROID_Human0.97859785
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97700293
128TP63_22573176_ChIP-Seq_HFKS_Human0.97404007
129ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97284255
130ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97170856
131VDR_23849224_ChIP-Seq_CD4+_Human0.97156744
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96765025
133E2F1_20622854_ChIP-Seq_HELA_Human0.96687569
134CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95917523
135TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95778644
136RXR_22158963_ChIP-Seq_LIVER_Mouse0.95712331
137TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95465860
138CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95202792
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94841764
140* NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94328093
141RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93685075
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93596783
143KLF5_25053715_ChIP-Seq_YYC3_Human0.93207114
144UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93178052
145GATA3_24758297_ChIP-Seq_MCF-7_Human0.92945730
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.92152253
147ESR1_21235772_ChIP-Seq_MCF-7_Human0.91254972
148GATA1_22025678_ChIP-Seq_K562_Human0.91045052
149ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90651939
150* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90642050
151BCOR_27268052_Chip-Seq_Bcells_Human0.90334602
152STAT1_20625510_ChIP-Seq_HELA_Human0.89992786
153* POU5F1_16518401_ChIP-PET_MESCs_Mouse0.89783692
154P68_20966046_ChIP-Seq_HELA_Human0.89575029
155PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89397221
156RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89274690
157* CREB1_26743006_Chip-Seq_LNCaP_Human0.89186839
158PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.88719392

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell4.69761991
2MP0004264_abnormal_extraembryonic_tissu4.65291126
3MP0001666_abnormal_nutrient_absorption3.91208431
4MP0005360_urolithiasis3.84155431
5MP0010234_abnormal_vibrissa_follicle3.74600182
6MP0000462_abnormal_digestive_system3.48564389
7MP0003315_abnormal_perineum_morphology3.39621205
8* MP0004957_abnormal_blastocyst_morpholog3.25015962
9MP0003878_abnormal_ear_physiology3.18231924
10MP0005377_hearing/vestibular/ear_phenot3.18231924
11MP0000537_abnormal_urethra_morphology3.09459115
12MP0003866_abnormal_defecation3.06435769
13MP0003183_abnormal_peptide_metabolism2.94741591
14* MP0003693_abnormal_embryo_hatching2.94202758
15MP0000490_abnormal_crypts_of2.65291801
16MP0002796_impaired_skin_barrier2.37697375
17MP0004019_abnormal_vitamin_homeostasis2.29624469
18MP0002822_catalepsy2.27337455
19MP0005409_darkened_coat_color2.16402788
20MP0005085_abnormal_gallbladder_physiolo2.08638114
21MP0000678_abnormal_parathyroid_gland2.06168070
22MP0003705_abnormal_hypodermis_morpholog2.03729237
23* MP0000477_abnormal_intestine_morphology1.98887034
24MP0003941_abnormal_skin_development1.98760169
25MP0003806_abnormal_nucleotide_metabolis1.92149051
26MP0003718_maternal_effect1.87065714
27MP0005381_digestive/alimentary_phenotyp1.85232588
28MP0010155_abnormal_intestine_physiology1.80873583
29* MP0003111_abnormal_nucleus_morphology1.80323210
30MP0001663_abnormal_digestive_system1.80322380
31MP0003283_abnormal_digestive_organ1.70908567
32MP0004858_abnormal_nervous_system1.70494622
33MP0008875_abnormal_xenobiotic_pharmacok1.65439808
34MP0005670_abnormal_white_adipose1.63356644
35MP0001873_stomach_inflammation1.63123382
36MP0003868_abnormal_feces_composition1.62854576
37MP0005166_decreased_susceptibility_to1.59271810
38MP0001730_embryonic_growth_arrest1.58055863
39MP0002876_abnormal_thyroid_physiology1.49534418
40MP0001188_hyperpigmentation1.47264174
41MP0003567_abnormal_fetal_cardiomyocyte1.46532462
42MP0010678_abnormal_skin_adnexa1.44053386
43MP0005636_abnormal_mineral_homeostasis1.43058951
44MP0005501_abnormal_skin_physiology1.42964623
45MP0002139_abnormal_hepatobiliary_system1.37713614
46MP0002138_abnormal_hepatobiliary_system1.31260486
47MP0003191_abnormal_cellular_cholesterol1.28879541
48MP0002098_abnormal_vibrissa_morphology1.28844850
49MP0010329_abnormal_lipoprotein_level1.28420881
50MP0009643_abnormal_urine_homeostasis1.27555764
51MP0001756_abnormal_urination1.25852444
52MP0000566_synostosis1.22888632
53MP0010030_abnormal_orbit_morphology1.22001196
54MP0004043_abnormal_pH_regulation1.21338628
55MP0003938_abnormal_ear_development1.20415405
56MP0004782_abnormal_surfactant_physiolog1.20250793
57MP0008260_abnormal_autophagy1.17501147
58MP0006035_abnormal_mitochondrial_morpho1.16909895
59* MP0002086_abnormal_extraembryonic_tissu1.16298734
60MP0001849_ear_inflammation1.15631033
61MP0009053_abnormal_anal_canal1.14793677
62* MP0001672_abnormal_embryogenesis/_devel1.14740961
63* MP0005380_embryogenesis_phenotype1.14740961
64MP0005332_abnormal_amino_acid1.10814230
65MP0001664_abnormal_digestion1.07755202
66MP0001697_abnormal_embryo_size1.04348115
67MP0003252_abnormal_bile_duct1.03991946
68* MP0008932_abnormal_embryonic_tissue1.02870648
69MP0001216_abnormal_epidermal_layer1.02698936
70* MP0002088_abnormal_embryonic_growth/wei0.96017866
71MP0002118_abnormal_lipid_homeostasis0.95044259
72MP0000383_abnormal_hair_follicle0.94640884
73MP0000538_abnormal_urinary_bladder0.94530236
74* MP0003077_abnormal_cell_cycle0.93225350
75* MP0002080_prenatal_lethality0.91972652
76* MP0003984_embryonic_growth_retardation0.91900500
77MP0005058_abnormal_lysosome_morphology0.90830565
78MP0000350_abnormal_cell_proliferation0.89576950
79MP0005451_abnormal_body_composition0.88459076
80MP0002166_altered_tumor_susceptibility0.87993263
81* MP0002085_abnormal_embryonic_tissue0.87523964
82MP0005666_abnormal_adipose_tissue0.87300908
83MP0009333_abnormal_splenocyte_physiolog0.86377631
84MP0003123_paternal_imprinting0.85984488
85MP0009379_abnormal_foot_pigmentation0.84975574
86MP0000465_gastrointestinal_hemorrhage0.84860649
87MP0003303_peritoneal_inflammation0.84826395
88MP0005365_abnormal_bile_salt0.84344344
89MP0005023_abnormal_wound_healing0.84186576
90MP0003221_abnormal_cardiomyocyte_apopto0.83614195
91* MP0010352_gastrointestinal_tract_polyps0.82745689
92MP0001765_abnormal_ion_homeostasis0.81324220
93MP0002089_abnormal_postnatal_growth/wei0.79950871
94MP0000230_abnormal_systemic_arterial0.79778242
95MP0000377_abnormal_hair_follicle0.79202762
96MP0002249_abnormal_larynx_morphology0.78982810
97MP0000762_abnormal_tongue_morphology0.78953555
98MP0001845_abnormal_inflammatory_respons0.78455861
99MP0005319_abnormal_enzyme/_coenzyme0.78434620
100MP0008004_abnormal_stomach_pH0.77875992
101MP0003724_increased_susceptibility_to0.77360894
102MP0003329_amyloid_beta_deposits0.75046201
103MP0002896_abnormal_bone_mineralization0.74858252
104MP0002971_abnormal_brown_adipose0.73915943
105MP0005167_abnormal_blood-brain_barrier0.73367945
106MP0005367_renal/urinary_system_phenotyp0.73201337
107MP0000516_abnormal_urinary_system0.73201337
108MP0002009_preneoplasia0.72598304
109MP0001485_abnormal_pinna_reflex0.72488853
110MP0005584_abnormal_enzyme/coenzyme_acti0.72181618
111MP0009785_altered_susceptibility_to0.71509638
112MP0005448_abnormal_energy_balance0.71088581
113MP0005310_abnormal_salivary_gland0.70942057
114* MP0002084_abnormal_developmental_patter0.70111355
115MP0000681_abnormal_thyroid_gland0.69287744
116MP0005075_abnormal_melanosome_morpholog0.69066793
117MP0008872_abnormal_physiological_respon0.68330584
118MP0004947_skin_inflammation0.66592193
119MP0003879_abnormal_hair_cell0.66337646
120MP0009115_abnormal_fat_cell0.65586911
121MP0000358_abnormal_cell_content/0.64940149
122MP0000467_abnormal_esophagus_morphology0.64697070
123MP0005395_other_phenotype0.64668924
124MP0003300_gastrointestinal_ulcer0.64234397
125MP0000609_abnormal_liver_physiology0.63942645
126MP0002006_tumorigenesis0.63120337
127MP0005025_abnormal_response_to0.63009069
128MP0004197_abnormal_fetal_growth/weight/0.62066904
129MP0001881_abnormal_mammary_gland0.61150695
130MP0005266_abnormal_metabolism0.60919631
131MP0002136_abnormal_kidney_physiology0.60596590
132MP0004147_increased_porphyrin_level0.60577021
133* MP0003119_abnormal_digestive_system0.60498600
134MP0003566_abnormal_cell_adhesion0.59585436
135MP0000647_abnormal_sebaceous_gland0.58941509
136MP0003453_abnormal_keratinocyte_physiol0.58516931
137MP0001764_abnormal_homeostasis0.57329520
138MP0009642_abnormal_blood_homeostasis0.56229547
139MP0005187_abnormal_penis_morphology0.56042818
140MP0004185_abnormal_adipocyte_glucose0.55616906
141MP0006082_CNS_inflammation0.55340657
142MP0003950_abnormal_plasma_membrane0.54990084
143MP0000627_abnormal_mammary_gland0.54225907
144MP0003436_decreased_susceptibility_to0.53323990
145* MP0002111_abnormal_tail_morphology0.52725585
146* MP0003937_abnormal_limbs/digits/tail_de0.52696587
147MP0004270_analgesia0.52189883
148MP0000604_amyloidosis0.51981743

Predicted human phenotypes

RankGene SetZ-score
1Ileus (HP:0002595)8.58446213
2Decreased circulating renin level (HP:0003351)5.29461107
3Hydroxyprolinuria (HP:0003080)5.03061887
4Abnormality of proline metabolism (HP:0010907)5.03061887
5Abnormality of renin-angiotensin system (HP:0000847)4.68488514
6Alkalosis (HP:0001948)4.25486187
7Chronic diarrhea (HP:0002028)4.14213288
8Systemic lupus erythematosus (HP:0002725)4.09592594
9Multiple enchondromatosis (HP:0005701)4.08954677
10Septate vagina (HP:0001153)4.04023584
11Malnutrition (HP:0004395)4.03948468
12Right ventricular cardiomyopathy (HP:0011663)3.94303888
13Abdominal distention (HP:0003270)3.62785479
14Gastrointestinal dysmotility (HP:0002579)3.62097963
15Confusion (HP:0001289)3.54643613
16Congenital sensorineural hearing impairment (HP:0008527)3.42869530
17Myopathic facies (HP:0002058)3.37506842
18Abnormality of the 1st metacarpal (HP:0010009)3.35144129
19Micronodular cirrhosis (HP:0001413)3.26545879
20Cheilitis (HP:0100825)3.26501118
21Hemorrhage of the eye (HP:0011885)3.23921399
22Breast hypoplasia (HP:0003187)3.22533586
23Ventricular fibrillation (HP:0001663)3.15212855
24Abnormality of small intestinal villus morphology (HP:0011472)3.11972362
25Villous atrophy (HP:0011473)3.11972362
26Trismus (HP:0000211)3.06438614
27Hyperparathyroidism (HP:0000843)2.96941550
28Wide cranial sutures (HP:0010537)2.90987521
29Thin bony cortex (HP:0002753)2.88149731
30Abnormal cartilage morphology (HP:0002763)2.83824045
31Microretrognathia (HP:0000308)2.82569989
32Pustule (HP:0200039)2.81632824
33Nausea (HP:0002018)2.76965335
34Megaloblastic anemia (HP:0001889)2.76443509
35Pili torti (HP:0003777)2.72243292
36Macrocytic anemia (HP:0001972)2.71881084
37Hyperaldosteronism (HP:0000859)2.68040931
38Tongue fasciculations (HP:0001308)2.61858881
39Bundle branch block (HP:0011710)2.60296273
40Nephrolithiasis (HP:0000787)2.56357259
41Proximal tubulopathy (HP:0000114)2.56272942
42Polycythemia (HP:0001901)2.56191330
43Metabolic alkalosis (HP:0200114)2.54659662
44Hypokalemia (HP:0002900)2.54143256
45Hypobetalipoproteinemia (HP:0003563)2.53978420
46Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49948024
47Eczematoid dermatitis (HP:0000976)2.48579725
48Hyperuricemia (HP:0002149)2.48255222
49Increased purine levels (HP:0004368)2.48255222
50Abnormal hair laboratory examination (HP:0003328)2.48072353
51Intrahepatic cholestasis (HP:0001406)2.47830592
52Abnormality of liposaccharide metabolism (HP:0010968)2.46431741
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.46431741
54Abnormality of glycolipid metabolism (HP:0010969)2.46431741
55Posterior subcapsular cataract (HP:0007787)2.46043555
56Hyperactive renin-angiotensin system (HP:0000841)2.45436953
57Congenital ichthyosiform erythroderma (HP:0007431)2.45062665
58Atrioventricular block (HP:0001678)2.42632759
59Pigmentary retinal degeneration (HP:0001146)2.41923795
60Abnormality of glutamine family amino acid metabolism (HP:0010902)2.41272536
61Renal tubular acidosis (HP:0001947)2.40758272
62Hyperglycinuria (HP:0003108)2.40300064
63Hypotension (HP:0002615)2.38685088
64Muscle fibrillation (HP:0010546)2.38404758
65Prolonged neonatal jaundice (HP:0006579)2.36891470
66Abnormal biliary tract morphology (HP:0012440)2.36086503
67Hyponatremia (HP:0002902)2.32610130
68Abnormality of glycine metabolism (HP:0010895)2.31874734
69Abnormality of serine family amino acid metabolism (HP:0010894)2.31874734
70Reticulocytopenia (HP:0001896)2.31430038
71Alopecia of scalp (HP:0002293)2.28542848
72Breech presentation (HP:0001623)2.27886394
73Esophageal varix (HP:0002040)2.27308238
74Abnormality of complement system (HP:0005339)2.25363881
75Flat acetabular roof (HP:0003180)2.25245215
76Aplasia/hypoplasia of the humerus (HP:0006507)2.24397464
77Rough bone trabeculation (HP:0100670)2.23123045
78Abnormal tarsal ossification (HP:0008369)2.22475989
79Hypolipoproteinemia (HP:0010981)2.22110938
80Cupped ribs (HP:0000887)2.21891600
81Growth hormone excess (HP:0000845)2.21776581
82Abnormality of the vitamin B12 metabolism (HP:0004341)2.21657847
83Abnormality of cells of the erythroid lineage (HP:0012130)2.21151422
84Hypophosphatemia (HP:0002148)2.19458905
85Rectal prolapse (HP:0002035)2.19250303
86Glomerulonephritis (HP:0000099)2.18358894
87Spastic paraparesis (HP:0002313)2.18089447
88Short phalanx of the thumb (HP:0009660)2.17855557
89Delayed epiphyseal ossification (HP:0002663)2.17327643
90Gout (HP:0001997)2.17226909
91Abnormality of magnesium homeostasis (HP:0004921)2.16913275
92Hyperphosphatemia (HP:0002905)2.16664037
93Biliary tract neoplasm (HP:0100574)2.16544175
94Athetosis (HP:0002305)2.15038791
95Abnormality of potassium homeostasis (HP:0011042)2.14864135
96Conjugated hyperbilirubinemia (HP:0002908)2.14476910
97Carpal bone hypoplasia (HP:0001498)2.14295346
98Abnormality of chloride homeostasis (HP:0011422)2.14223891
99Heart block (HP:0012722)2.13996692
100Poor head control (HP:0002421)2.11499713
101Abnormal atrioventricular conduction (HP:0005150)2.10731774
102Abnormality of pyrimidine metabolism (HP:0004353)2.09205114
103Abnormality of the umbilical cord (HP:0010881)2.08365101
104Concave nail (HP:0001598)2.08070292
105Cerebral hypomyelination (HP:0006808)2.08060376
106Late onset (HP:0003584)2.06720120
107Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.05493884
108Short 1st metacarpal (HP:0010034)2.04450184
109Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.04450184
110Steatorrhea (HP:0002570)2.04121898
111Cerebral palsy (HP:0100021)2.03965710
112Abnormality of nucleobase metabolism (HP:0010932)2.03496835
113Uterine neoplasm (HP:0010784)2.02680151
114Subcapsular cataract (HP:0000523)2.01982611
115Male infertility (HP:0003251)2.01651227
116Abnormality of purine metabolism (HP:0004352)2.00880540
117Abnormality of vitamin B metabolism (HP:0004340)2.00091841
118Complement deficiency (HP:0004431)1.99767887
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98629035
120Flattened epiphyses (HP:0003071)1.97395160
121Secondary amenorrhea (HP:0000869)1.96738265
122Dicarboxylic aciduria (HP:0003215)1.95964152
123Abnormality of dicarboxylic acid metabolism (HP:0010995)1.95964152
124Symptomatic seizures (HP:0011145)1.95652533
125Abnormality of vitamin metabolism (HP:0100508)1.94986614
126Abnormality of the phalanges of the hallux (HP:0010057)1.93871836
127Pancreatitis (HP:0001733)1.93456452
128Abnormality of the distal phalanges of the toes (HP:0010182)1.93198870
129Dehydration (HP:0001944)1.93076711
130Congenital malformation of the right heart (HP:0011723)1.91510984
131Double outlet right ventricle (HP:0001719)1.91510984
132Petechiae (HP:0000967)1.91277743
133Short humerus (HP:0005792)1.91080265
134Syncope (HP:0001279)1.90673699
135Protuberant abdomen (HP:0001538)1.90211858
136Hyperammonemia (HP:0001987)1.89845629
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89470002
138Acanthocytosis (HP:0001927)1.89067833
139Nephritis (HP:0000123)1.87512324
140Sparse eyelashes (HP:0000653)1.87380290
141Abnormality of urine glucose concentration (HP:0011016)1.87120456
142Glycosuria (HP:0003076)1.87120456
143Metabolic acidosis (HP:0001942)1.86580171
144Malignant gastrointestinal tract tumors (HP:0006749)1.86458572
145Gastrointestinal carcinoma (HP:0002672)1.86458572
146Multiple lipomas (HP:0001012)1.86342275
147Facial shape deformation (HP:0011334)1.86269276
148Potter facies (HP:0002009)1.86269276
149Abnormal number of erythroid precursors (HP:0012131)1.85738025
150Abnormality of carpal bone ossification (HP:0006257)1.85619114
151Visceral angiomatosis (HP:0100761)1.85525968
152Xanthomatosis (HP:0000991)1.84701398
153Curly hair (HP:0002212)1.84310590
154Fat malabsorption (HP:0002630)1.83371321
155Fragile nails (HP:0001808)1.81437401
156Widely patent fontanelles and sutures (HP:0004492)1.80788269
157Premature ovarian failure (HP:0008209)1.79243209
158Absent radius (HP:0003974)1.77675186
159Abnormality of the distal phalanx of the thumb (HP:0009617)1.76310945
160Palpitations (HP:0001962)1.75847343
161Focal segmental glomerulosclerosis (HP:0000097)1.75324561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.82864118
2ACVR1B5.82685702
3BUB14.13265454
4ERN13.68614376
5WEE13.13333586
6MAP2K22.92983403
7NME12.83991187
8STK392.78566471
9TTK2.78193348
10PIK3CA2.73393353
11MST42.59761186
12GRK62.55640238
13LMTK22.50864104
14AKT32.29302307
15OXSR12.06308947
16RPS6KB22.03018235
17PRKG21.98060113
18MST1R1.93909358
19FGFR41.92452239
20FRK1.74519224
21IRAK31.71827486
22MAP3K81.67887401
23PRKCI1.66984905
24PLK41.66946192
25PAK41.59356472
26SMG11.56291431
27PRPF4B1.47413555
28STK241.45445463
29TSSK61.43989195
30PNCK1.39681771
31TESK21.36090563
32TAOK11.34128853
33NEK11.31781411
34TESK11.27573868
35NEK21.20477416
36MAP3K111.20117440
37STK161.18095638
38MAP3K11.16480885
39EPHB21.13984668
40WNK41.11920214
41ZAK1.10737398
42MAP3K121.10181550
43AURKB1.09363407
44TYK21.08162838
45MAP3K21.01747841
46MAP4K11.01652119
47ABL21.01632399
48PLK10.96966187
49BRAF0.95270144
50ARAF0.94499955
51SCYL20.89299982
52TNIK0.88443679
53EEF2K0.88102720
54PIM20.87568794
55PAK10.87457367
56EIF2AK10.82738299
57KDR0.82590508
58CDC42BPA0.81763976
59MET0.80853181
60EPHB10.80806088
61MAP2K10.80227113
62STK100.76944755
63MAP2K60.76197976
64CHEK20.74918690
65NME20.74716493
66MAP3K30.74351927
67MYLK0.74117194
68EPHA30.71911706
69CAMK2G0.71347590
70RIPK40.69354440
71CAMK2B0.68039660
72FGFR30.68035632
73STK38L0.67617109
74TBK10.67379234
75AURKA0.66009888
76ALK0.65730156
77CAMK2D0.64837100
78MARK10.64691390
79PRKAA20.63445705
80CDK70.61823627
81BRSK20.60476674
82PDPK10.60201194
83PTK20.58926734
84ERBB20.58580223
85PDK20.58190668
86SRPK10.57488958
87MAP3K100.55783194
88KSR20.52133890
89RIPK10.51595667
90PTK60.50572504
91MATK0.50521049
92DYRK1B0.49846435
93CDK190.49514888
94CDK40.47724226
95EPHA40.47543076
96ICK0.47434306
97FER0.46868464
98CDK120.46633031
99PDK40.44667271
100PDK30.44667271
101GRK10.43568425
102PRKACG0.42516877
103DDR20.42256450
104CSNK1E0.42089986
105LRRK20.39921140
106NLK0.39629449
107DAPK30.39481811
108SRC0.38170470
109DYRK30.36993939
110BMX0.34671300
111DMPK0.33322618
112TRIB30.33208278
113TAOK20.31835730
114AKT20.31694784
115PLK30.31589161
116TAOK30.29292866
117IRAK10.29281705
118PRKCZ0.29174282
119PRKCA0.28533672
120CHEK10.27593320
121CSNK1A10.27122685
122PDGFRA0.27118280
123PBK0.26578581
124CSNK2A10.26265801
125RET0.26257950
126CDK60.25863043
127* CDK20.24352867
128CSK0.24332886
129ZAP700.24189045
130PRKCD0.23049706
131PDK10.23034946
132MAPKAPK20.21994704
133IRAK20.21553273
134CAMKK20.20572617
135STK30.19381995
136YES10.18814073
137IKBKE0.18551121
138FYN0.18435827
139PIM10.18419122
140MAPK110.18071705
141RPS6KL10.17880906
142RPS6KC10.17880906
143RPS6KA20.16686855
144LIMK10.16251811
145MELK0.16055196
146MAP3K140.14249716
147SIK10.14241188
148JAK20.13591255

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.32987872
2Fat digestion and absorption_Homo sapiens_hsa049753.40553031
3Fructose and mannose metabolism_Homo sapiens_hsa000513.33650411
4Mineral absorption_Homo sapiens_hsa049783.17039220
5Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.91049631
6Proteasome_Homo sapiens_hsa030502.84676252
7Sulfur metabolism_Homo sapiens_hsa009202.76449445
8Galactose metabolism_Homo sapiens_hsa000522.63360946
9Renin-angiotensin system_Homo sapiens_hsa046142.59140669
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.58406650
11Ribosome_Homo sapiens_hsa030102.48828190
12Drug metabolism - other enzymes_Homo sapiens_hsa009832.42995541
13Folate biosynthesis_Homo sapiens_hsa007902.23454442
14Pentose and glucuronate interconversions_Homo sapiens_hsa000402.22933108
15Vitamin digestion and absorption_Homo sapiens_hsa049772.17710462
16Pentose phosphate pathway_Homo sapiens_hsa000302.02948054
17Histidine metabolism_Homo sapiens_hsa003401.76224909
18Glutathione metabolism_Homo sapiens_hsa004801.70863547
19DNA replication_Homo sapiens_hsa030301.61909745
20Tight junction_Homo sapiens_hsa045301.61906936
21Pyrimidine metabolism_Homo sapiens_hsa002401.49992400
22Starch and sucrose metabolism_Homo sapiens_hsa005001.38620035
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34540138
24RNA polymerase_Homo sapiens_hsa030201.31115494
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.28924272
26Caffeine metabolism_Homo sapiens_hsa002321.26330361
27Sphingolipid metabolism_Homo sapiens_hsa006001.25876118
28Carbon metabolism_Homo sapiens_hsa012001.23301098
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.21540018
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18057104
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17907937
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.17806171
33Arginine and proline metabolism_Homo sapiens_hsa003301.16382209
34Asthma_Homo sapiens_hsa053101.10685430
35Bile secretion_Homo sapiens_hsa049761.09275744
36Glycerophospholipid metabolism_Homo sapiens_hsa005641.09018844
37RNA transport_Homo sapiens_hsa030131.07904676
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.05961015
39Homologous recombination_Homo sapiens_hsa034401.05476134
40Mismatch repair_Homo sapiens_hsa034301.05234928
41Oxidative phosphorylation_Homo sapiens_hsa001901.04339612
42Pancreatic secretion_Homo sapiens_hsa049721.02036117
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00973172
44Glycerolipid metabolism_Homo sapiens_hsa005611.00162959
45Intestinal immune network for IgA production_Homo sapiens_hsa046720.99537744
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97803265
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.94256487
48Vitamin B6 metabolism_Homo sapiens_hsa007500.93782303
49Protein digestion and absorption_Homo sapiens_hsa049740.91318076
50Spliceosome_Homo sapiens_hsa030400.91142274
51Arachidonic acid metabolism_Homo sapiens_hsa005900.90801220
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.90677724
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90518019
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87951618
55Parkinsons disease_Homo sapiens_hsa050120.86313187
56Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81754032
57Regulation of autophagy_Homo sapiens_hsa041400.79632649
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.79427101
59Huntingtons disease_Homo sapiens_hsa050160.79020990
60Allograft rejection_Homo sapiens_hsa053300.78011847
61Tryptophan metabolism_Homo sapiens_hsa003800.76716615
62Chemical carcinogenesis_Homo sapiens_hsa052040.76541042
63Retinol metabolism_Homo sapiens_hsa008300.72974869
64Base excision repair_Homo sapiens_hsa034100.72128571
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71745925
66Autoimmune thyroid disease_Homo sapiens_hsa053200.71361039
67Biosynthesis of amino acids_Homo sapiens_hsa012300.71137878
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71054323
69Phenylalanine metabolism_Homo sapiens_hsa003600.70109429
70Thyroid cancer_Homo sapiens_hsa052160.69431164
71Metabolic pathways_Homo sapiens_hsa011000.68973595
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68198640
73Purine metabolism_Homo sapiens_hsa002300.67604018
74Ether lipid metabolism_Homo sapiens_hsa005650.67159714
75Graft-versus-host disease_Homo sapiens_hsa053320.65371541
76Staphylococcus aureus infection_Homo sapiens_hsa051500.64924712
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64321211
78beta-Alanine metabolism_Homo sapiens_hsa004100.63232657
79Sulfur relay system_Homo sapiens_hsa041220.63186048
80Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60769369
81Alzheimers disease_Homo sapiens_hsa050100.60614567
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60333090
83Cell cycle_Homo sapiens_hsa041100.58025046
84Hippo signaling pathway_Homo sapiens_hsa043900.57727218
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.56173587
86Nucleotide excision repair_Homo sapiens_hsa034200.55790028
87Fatty acid metabolism_Homo sapiens_hsa012120.55673963
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53708373
89Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51521115
90Linoleic acid metabolism_Homo sapiens_hsa005910.51058295
91Fatty acid degradation_Homo sapiens_hsa000710.50410862
92Type I diabetes mellitus_Homo sapiens_hsa049400.48374086
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.47979906
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.45757860
95Peroxisome_Homo sapiens_hsa041460.45284473
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45009116
97Cysteine and methionine metabolism_Homo sapiens_hsa002700.43433631
98Selenocompound metabolism_Homo sapiens_hsa004500.42934701
99PPAR signaling pathway_Homo sapiens_hsa033200.41356040
100Adherens junction_Homo sapiens_hsa045200.41022304
101Hedgehog signaling pathway_Homo sapiens_hsa043400.40185499
102Bladder cancer_Homo sapiens_hsa052190.38951411
103Tyrosine metabolism_Homo sapiens_hsa003500.38709063
104Vibrio cholerae infection_Homo sapiens_hsa051100.38651749
105Steroid biosynthesis_Homo sapiens_hsa001000.37522885
106p53 signaling pathway_Homo sapiens_hsa041150.34505555
107Antigen processing and presentation_Homo sapiens_hsa046120.34240456
108Other glycan degradation_Homo sapiens_hsa005110.33972517
109Nitrogen metabolism_Homo sapiens_hsa009100.33570253
110Salmonella infection_Homo sapiens_hsa051320.33278031
111Thyroid hormone synthesis_Homo sapiens_hsa049180.33106519
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32454073
113Hepatitis C_Homo sapiens_hsa051600.29294499
114Leishmaniasis_Homo sapiens_hsa051400.28381837
115Fatty acid biosynthesis_Homo sapiens_hsa000610.27238982
116Pyruvate metabolism_Homo sapiens_hsa006200.27184401
117Butanoate metabolism_Homo sapiens_hsa006500.26420801
118Insulin resistance_Homo sapiens_hsa049310.25955820
119Pertussis_Homo sapiens_hsa051330.25512727
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.24112685
121Arginine biosynthesis_Homo sapiens_hsa002200.23576925
122Renin secretion_Homo sapiens_hsa049240.23133376
123One carbon pool by folate_Homo sapiens_hsa006700.20941067
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20320256
125Viral myocarditis_Homo sapiens_hsa054160.15921071
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.15204869
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.12414454
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12252860
129Propanoate metabolism_Homo sapiens_hsa006400.11466414
130Fatty acid elongation_Homo sapiens_hsa000620.08622801
131Toxoplasmosis_Homo sapiens_hsa051450.06974582
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.06622755
133Influenza A_Homo sapiens_hsa051640.03284111
134African trypanosomiasis_Homo sapiens_hsa051430.03148205
135Glucagon signaling pathway_Homo sapiens_hsa049220.01619534
136Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.00960035
137GnRH signaling pathway_Homo sapiens_hsa049120.00895122
138AMPK signaling pathway_Homo sapiens_hsa041520.00178051

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